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187 results on '"Kato, Noritoshi"'

10. Association of calciprotein particles with serum phosphorus among patients undergoing conventional and extended-hours haemodialysis

Author

Nishibori, Nobuhiro, primary, Okazaki, Masaki, additional, Miura, Yutaka, additional, Hishida, Manabu, additional, Kurasawa, Shimon, additional, Imaizumi, Takahiro, additional, Kato, Noritoshi, additional, Kosugi, Tomoki, additional, Kuro-o, Makoto, additional, Kasuga, Hirotake, additional, Kaneda, Fumika, additional, and Maruyama, Shoichi, additional

Published
2024
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13. A novel renal perivascular mesenchymal cell subset gives rise to fibroblasts distinct from classic myofibroblasts

Author

Minatoguchi, Shun, Saito, Shoji, Furuhashi, Kazuhiro, Sawa, Yuriko, Okazaki, Masaki, Shimamura, Yuko, Kaihan, Ahmad Baseer, Hashimoto, Yusaku, Yasuda, Yoshinari, Hara, Akitoshi, Mizutani, Yasuyuki, Ando, Ryota, Kato, Noritoshi, Ishimoto, Takuji, Tsuboi, Naotake, Esaki, Nobutoshi, Matsuyama, Makoto, Shiraki, Yukihiro, Kobayashi, Hiroki, Asai, Naoya, Enomoto, Atsushi, and Maruyama, Shoichi

Published
2022
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15. Genetic reprogramming with stem cells regenerates glomerular epithelial podocytes in Alport syndrome

Author

LeBleu, Valerie S, primary, Kanasaki, Keizo, additional, Lovisa, Sara, additional, Alge, Joseph L, additional, Kim, Jiha, additional, Chen, Yang, additional, Teng, Yingqi, additional, Gerami-Naini, Behzad, additional, Sugimoto, Hikaru, additional, Kato, Noritoshi, additional, Revuelta, Ignacio, additional, Grau, Nicole, additional, Sleeman, Jonathan P, additional, Taduri, Gangadhar, additional, Kizu, Akane, additional, Rafii, Shahin, additional, Hochedlinger, Konrad, additional, Quaggin, Susan E, additional, and Kalluri, Raghu, additional

Published
2024
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16. Case report: A family of atypical hemolytic uremic syndrome involving a CFH::CFHR1 fusion gene and CFHR3-1-4-2 gene duplication

Author

Tasaki, Yuko, primary, Tsujimoto, Hiroshi, additional, Yokoyama, Tadafumi, additional, Sugimoto, Naotoshi, additional, Kitajima, Shinji, additional, Fujii, Hiroshi, additional, Hidaka, Yoshihiko, additional, Kato, Noritoshi, additional, Maruyama, Shoichi, additional, Inoue, Norimitsu, additional, and Wada, Taizo, additional

Published
2024
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28. Clinical characteristics of anti-GBM disease with thrombotic microangiopathy: a case report and literature review

Author

Nakamura, Yoshihiro, primary, Kato, Noritoshi, additional, Tatematsu, Yoshitaka, additional, Arai, Yoshifumi, additional, Mori, Nozomi, additional, Shibata, Katsuaki, additional, Yamazaki, Michiko, additional, Yasui, Hirotoshi, additional, Fujiwara, Shinji, additional, Yamakawa, Taishi, additional, and Maruyama, Shoichi, additional

Published
2023
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32. MO316: Eculizumab for Adult Patients With Atypical Haemolytic-Uremic Syndrome: Full Dataset Analysis of Post-Marketing Surveillance in Japan

Author

Maruyama, Shoichi, primary, Ikeda, Yoichiro, additional, Kaname, Shinya, additional, Kato, Noritoshi, additional, Matsumoto, Masanori, additional, Ishikawa, Yumiko, additional, Shimono, Akihiko, additional, Miyakawa, Yoshitaka, additional, Nangaku, Masaomi, additional, Shibagaki, Yugo, additional, and Okada, Hirokazu, additional

Published
2022
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34. Additional file 1 of Systematic characterization of seed overlap microRNA cotargeting associated with lupus pathogenesis

Author

Kitai, Hiroki, Kato, Noritoshi, Ogami, Koichi, Komatsu, Shintaro, Watanabe, Yu, Yoshino, Seiko, Koshi, Eri, Tsubota, Shoma, Funahashi, Yoshio, Maeda, Takahiro, Furuhashi, Kazuhiro, Ishimoto, Takuji, Kosugi, Tomoki, Maruyama, Shoichi, Kadomatsu, Kenji, and Suzuki, Hiroshi I.

Abstract

Additional file 1: Fig. S1. Additional results of qRT-PCR analysis. Additional validation of downregulated miRNAs by qRT-PCR. Data are means ± SD (N = 8-12). Fig. S2. Characterization of the human pDC-like cell line CAL-1. (A-C) FACS analysis of the cell-surface markers CD11c (A), CD304 (B), and CD123 (C) in CAL-1 cells. Isotype controls are shown in blue. Fig. S3. Overexpression of miR-128 and miR-148a in CAL-1 and HeLa cells. (A) Overexpression of miR-128-3p and miR-148a-3p in CAL-1 cells. Transfection with miR-control, miR-128-3p and miR-control, miR-148a-3p and miR-control, or miR-128-3p and miR-148a-3p, followed by qRT-PCR analysis (N = 3 per group, ***P < 0.001, ****P < 0.0001, one-way ANOVA and post hoc Tukey test). (B) Overexpression of miR-128-3p and miR-148a-3p in HeLa cells. HeLa cells were transfected with pri-miRNA empty or overexpression plasmids. At 48 hours after transfection, qRT-PCR analyses were performed (N = 3 per group, **P < 0.01, ***P < 0.001, one-way ANOVA and post hoc Tukey test). Fig. S4. Transcriptomic effects of miR-128 and miR-148a overexpression in HeLa cells. (A) Principal component analysis (left) and K-means clustering analysis (right) of the 1,000 most variable genes in RNA-seq datasets. The bottom panel shows enrichment of miR-128-3p and mIR-148a-3p target genes in each DEG group, classified by K-means clustering analysis. (B, C) Cumulative distributions of fold changes (FCs) of genes with single 8mer, 7mer-m8, 7mer-A1, and 6mer sites of miR-128-3p (B) and miR-148a-3p (C) upon single or double miRNA transfection. P values for downregulation (vs. genes with no sites) were calculated by one-tailed Wilcoxon rank sum test. Fig. S5. Deep conservation of KLF4 seed overlap cotarget sites between human and Coelacanth. TargetScan sequence alignments around the seed overlap cotarget site within KLF4 3′ UTRs are shown. Fig. S6. Conservation trends of miRNA target sites based on TargetScan and MirGeneDB classification. (A) Density and contour plots showing the distribution of BLS values and number of species in which the sites are conserved. Results for target sites of major miRNA groups in TargetScan (top) and MirGeneDB (bottom) classification are shown. (B) Conservation patterns of non-conserved sites, conserved sites, two classes of conserved sites for major miRNA groups in TargetScan (top) and MirGeneDB (bottom) classification across 84 vertebrate species (according to the species number threshold (n = 62)). Fig. S7. Additional seed overlap analysis of miRNA genes. (A) Summary showing relative occurrence (dashed lines) and statistics (-log10(P value), solid lines) of the maximum overlap for each seed type (8mer, 7mer-m8, 7mer-A1, and 6mer) among all pairs of (1) broadly conserved miRNAs, (2) broadly conserved and conserved miRNAs, and (3) broadly conserved, conserved, and poorly conserved miRNAs. Note that the results were similar when different miRNA groups were combined. (B) Frequency of extensive seed overlap in real data (vertical lines) and GC content-matched random seed sequences. Results of 1,000 randomizations are shown as density distributions. Fig. S8. Analysis of evolutionary trends in “seed overlap” miRNA cotargets and probability of haplo-insufficient genes. (A) Summary of differences and statistics of the number of species in which the sites are conserved. Target sites with “conserved overlap” and other target sites were compared. The results for the 50 miRNA pairs shown in Figure 7 are shown by site type. P values were calculated by one-tailed Wilcoxon rank sum test for either direction. (B) Summary of differences and statistics of the probability of haplo-insufficient genes between target genes with “conserved overlap” or other target sites. Results for 50 miRNA pairs shown in Figure 7 are shown. P values were calculated by one-tailed Wilcoxon rank sum test for either direction. Fig. S9. Additional seed overlap analysis of miRNA genes. Density and contour plots showing the distribution of BLS values and number of species in which the sites are conserved. Results for sites with “seed overlap” cotargeting (left), “neighborhood” cotargeting for the same miRNA (middle), and “neighborhood” cotargeting for all broadly conserved miRNAs (right) are shown. Vertical and horizontal dashed lines indicate BLC cutoffs (1.8 for 8mer, 2.8 for 7mer-m8, and 3.6 for 7mer-A1) and the species number threshold (n = 62). The trends do not markedly differ between groups. Fig. S10. Images of the full-size original blots. Uncropped images for Fig. 2 are shown.

Published
2022
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36. Basigin deficiency prevents anaplerosis and ameliorates insulin resistance and hepatosteatosis

Author

Ryuge, Akihiro, primary, Kosugi, Tomoki, additional, Maeda, Kayaho, additional, Banno, Ryoichi, additional, Gou, Yang, additional, Zaitsu, Kei, additional, Ito, Takanori, additional, Sato, Yuka, additional, Hirayama, Akiyoshi, additional, Tsubota, Shoma, additional, Honda, Takashi, additional, Nakajima, Kazuki, additional, Ozaki, Tomoya, additional, Kondoh, Kunio, additional, Takahashi, Kazuo, additional, Kato, Noritoshi, additional, Ishimoto, Takuji, additional, Soga, Tomoyoshi, additional, Nakagawa, Takahiko, additional, Koike, Teruhiko, additional, Arima, Hiroshi, additional, Yuzawa, Yukio, additional, Minokoshi, Yasuhiko, additional, Maruyama, Shoichi, additional, and Kadomatsu, Kenji, additional

Published
2021
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39. The growth factor midkine regulates the renin-angiotensin system in mice

Author

Hobo, Akinori, Yuzawa, Yukio, Kosugi, Tomoki, Kato, Noritoshi, Asai, Naoto, Sato, Waichi, Maruyama, Shoichi, Ito, Yasuhiko, Kobori, Hiroyuki, Ikematsu, Shinya, Nishiyama, Akira, Matsuo, Seiichi, and Kadomatsu, Kenji

Subjects
Growth factors -- Physiological aspects, Growth factors -- Research, Renin-angiotensin system -- Physiological aspects, Renin-angiotensin system -- Research, Sclerosis -- Risk factors, Sclerosis -- Genetic aspects, Sclerosis -- Research
Abstract

The renin-angiotensin system plays a pivotal role in regulating blood pressure and is involved in the pathogenesis of kidney disorders and other diseases. Here, we report that the growth factor midkine is what we believe to be a novel regulator of the renin-angiotensin system. The hypertension induced in mice by 5/6 nephrectomy was accompanied by renal damage and elevated plasma angiotensin II levels and was ameliorated by an angiotensin-converting enzyme (ACE) inhibitor and an angiotensin receptor blocker. Notably, ACE activity in the lung, midkine expression in the lung, and midkine levels in the plasma were all increased after 5/6 nephrectomy. Exposure to midkine protein enhanced ACE expression in primary cultured human lung microvascular endothelial cells. Furthermore, hypertension was not induced and renal damage was less severe in midkine-deficient mice. Supplemental administration of midkine protein to midkine-deficient mice restored ACE expression in the lung and hypertension after 5/6 nephrectomy. Oxidative stress might be involved in midkine expression, since expression of NADH/NADPH oxidase-1, -2, and -4 was induced in the lung after 5/6 nephrectomy. Indeed, the antioxidative reagent tempol reduced midkine expression and plasma angiotensin II levels and consequently ameliorated hypertension. These results suggest that midkine regulates the renin-angiotensin system and mediates the kidney-lung interaction after 5/6 nephrectomy., Introduction The renin-angiotensin system (RAS) is a hormonal cascade that functions in the homeostatic control of arterial pressure, tissue perfusion, and extracellular volume. Dysregulation of the RAS results in the [...]

Published
2009

43. X-chromosome inactivation patterns in females with Fabry disease examined by both ultra-deep RNA sequencing and methylation-dependent assay

Author

Rossanti, Rini, primary, Nozu, Kandai, additional, Fukunaga, Atsushi, additional, Nagano, China, additional, Horinouchi, Tomoko, additional, Yamamura, Tomohiko, additional, Sakakibara, Nana, additional, Minamikawa, Shogo, additional, Ishiko, Shinya, additional, Aoto, Yuya, additional, Okada, Eri, additional, Ninchoji, Takeshi, additional, Kato, Noritoshi, additional, Maruyama, Shoichi, additional, Nishi, Shinichi, additional, Iijima, Kazumoto, additional, and Fujii, Hideki, additional

Published
2020
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44. Endothelial-to-mesenchymal transition compromises vascular integrity to induce Myc-mediated metabolic reprogramming in kidney fibrosis

Author

Lovisa, Sara, primary, Fletcher-Sananikone, Eliot, additional, Sugimoto, Hikaru, additional, Hensel, Janine, additional, Lahiri, Sharmistha, additional, Hertig, Alexandre, additional, Taduri, Gangadhar, additional, Lawson, Erica, additional, Dewar, Rajan, additional, Revuelta, Ignacio, additional, Kato, Noritoshi, additional, Wu, Chang-Jiun, additional, Bassett, Roland L., additional, Putluri, Nagireddy, additional, Zeisberg, Michael, additional, Zeisberg, Elisabeth M., additional, LeBleu, Valerie S., additional, and Kalluri, Raghu, additional

Published
2020
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46. Fructose increases the activity of sodium hydrogen exchanger in renal proximal tubules that is dependent on ketohexokinase

Author

Hayasaki, Takahiro, primary, Ishimoto, Takuji, additional, Doke, Tomohito, additional, Hirayama, Akiyoshi, additional, Soga, Tomoyoshi, additional, Furuhashi, Kazuhiro, additional, Kato, Noritoshi, additional, Kosugi, Tomoki, additional, Tsuboi, Naotake, additional, Lanaspa, Miguel A., additional, Johnson, Richard J., additional, Maruyama, Shoichi, additional, and Kadomatsu, Kenji, additional

Published
2019
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48. Therapeutic efficacy of rituximab for the management of adult-onset steroid-dependent nephrotic syndrome: a retrospective study

Author

Katsuno, Takayuki, primary, Masuda, Tomohiro, additional, Saito, Shoji, additional, Kato, Noritoshi, additional, Ishimoto, Takuji, additional, Kato, Sawako, additional, Kosugi, Tomoki, additional, Tsuboi, Naotake, additional, Kitamura, Hiroshi, additional, Tsuzuki, Toyonori, additional, Ito, Yasuhiko, additional, and Maruyama, Shoichi, additional

Published
2018
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49. The clinical relevance of plasma CD147/basigin in biopsy-proven kidney diseases

Author

Mori, Yoshiko, primary, Masuda, Tomohiro, additional, Kosugi, Tomoki, additional, Yoshioka, Tomoki, additional, Hori, Mayuko, additional, Nagaya, Hiroshi, additional, Maeda, Kayaho, additional, Sato, Yuka, additional, Kojima, Hiroshi, additional, Kato, Noritoshi, additional, Ishimoto, Takuji, additional, Katsuno, Takayuki, additional, Yuzawa, Yukio, additional, Kadomatsu, Kenji, additional, and Maruyama, Shoichi, additional

Published
2017
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