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9. Fermented botanical fertilizer controls bacterial wilt of tomatoes caused by Ralstonia pseudosolanacearum.

Author

Hida, Akiko, Okano, Nanako, Tadokoro, Chika, Fukunishi, Myuji, Ahmed, Asmaa Ali, Takenaka, Kohei, Tateuchi, Yusuke, Fujioka, Kotaro, Torii, Hideto, Tajima, Takahisa, and Kato, Junichi

Subjects
BACTERIAL wilt diseases, TOMATOES, RALSTONIA, FERTILIZERS, PHYTOPATHOGENIC microorganisms
Abstract

This study demonstrates the effect of fermented botanical product (FBP) on Ralstonia pseudosolanacearum -induced bacterial wilt disease and unravels its action mechanism. Soaking with diluted FBP solutions (0.1%-0.5%) significantly suppressed bacterial wilt in tomato plants, and FBP-treated tomato plants grew well against R. pseudosolanacearum infection. Growth assays showed that FBP had no antibacterial effect but promoted R. pseudosolanacearum growth. In contrast, few or no R. pseudosolanacearum cells were detected in aerial parts of tomato plants grown in FBP-soaked soil. Subsequent infection assays using the chemotaxis-deficient mutant (Δ cheA) or the root-dip inoculation method revealed that FBP does not affect pathogen migration to plant roots during infection. Moreover, FBP-pretreated tomato plants exhibited reduced bacterial wilt in the absence of FBP. These findings suggest that the plant, but not the pathogen, could be affected by FBP, resulting in an induced resistance against R. pseudosolanacearum , leading to a suppressive effect on bacterial wilt. [ABSTRACT FROM AUTHOR]

Published
2024
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10. Metabolism-linked methylotaxis sensors responsible for plant colonization in Methylobacterium aquaticum strain 22A

Author

Tani, Akio, primary, Masuda, Sachiko, additional, Fujitani, Yoshiko, additional, Iga, Toshiki, additional, Haruna, Yuuki, additional, Kikuchi, Shiho, additional, Shuaile, Wang, additional, Lv, Haoxin, additional, Katayama, Shiori, additional, Yurimoto, Hiroya, additional, Sakai, Yasuyoshi, additional, and Kato, Junichi, additional

Published
2023
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11. Customer reactions and competitive responses to mergers in a B2B service industry

Author

Kato, Junichi and Schoenberg, Richard

Subjects
658.8
Abstract

The primary aim of this doctoral research was to empirically investigate customer and competitive reactions to post-M&A integration through both quantitative and qualitative customer perspectives, and to identify the business impact of these reactions and its potential causal mechanisms. The topic is widely recognised among practitioners but has received relatively little attention in the academic literature (Anderson et al., 2001; Schweiger and Very, 2003), which might explain the reason why decisive factors for M&A success are still elusive (Homburg and Bucerius, 2005). The research was carried out in three stages. Project-1 engaged in a systematic review of the marketing literature in order to build a foundation of knowledge on customer-supplier relationships. The review results were integrated into a literaturebased conceptual model, indicating the link between customer relationship management activities, customer loyalty and company performance, under ‘business as usual’ conditions. Based on this conceptual model, Project-2 empirically investigated post-M&A business issues through a single case study of multi-business mergers. Interviews with key account managers and their customers suggested a potential underlying causal mechanism of integration effects on customer-supplier relationships. Finally, Project-3 tested the key variables and interrelationships identified in Project-2 through a survey method in order to begin the process of generalization. Survey responses from business-to-business (B2B) customers were analysed by applying Structural Equation Modelling, which indicated potential causal correlations between integration activities, perceived changes in customer relationship variables and changes in the level of behavioural customer loyalty during the post-M&A period. The findings suggest a possible answer to the overall research question — what are the key factors that affect post-M&A business performance, or more specifically, what are the key variables that influence customer reactions and why/how? Post-M&A integration actions were found to trigger customer relationship issues. For instance, the integration of operations and IT systems leads to perceived deterioration in service performance, while salesforce integration creates organisational issues such as employees’ internally focused attitudes, which result in perceived declines in customer orientation and account management quality. Furthermore, integration actions as a whole generate an unstable business environment that promotes intensive competitive attacks. Some contextual factors which magnify these issues were also identified, specifically the complexity of the merger/integration and the depth of the pre-merger customer relationships. The issues above negatively influence customers’ purchase intentions and, in the worst cases, drove customers to terminate contracts, which would exert a negative impact on the merging parties’ business performance during the post- M&A integration period. The research has made a step towards a better understanding of how customers and competitors respond to post-M&A integration and the mechanisms by which those responses arise, particularly within the focal industry context of this study. It contributes to the M&A-integration and performance literature by illuminating the role and drivers of competitive attacks, and customer reactions in determining market-related M&A performance. It also contributes to the M&A-integration and business network literature by suggesting the mechanisms through which the customer-supplier relationship is impacted by post-M&A integration activities. Finally, contributions to practice and methodological development, as well as limitations and implications for future research, are also presented.

Published
2012

21. The multidomain intervention trial for prevention of dementia among older adults with type 2 diabetes: a multi‐center, randomized, 18‐month controlled trial.

Author

Sugimoto, Taiki, Araki, Atsushi, Fujita, Hiroki, Fujita, Kosuke, Honda, Keiko, Inagaki, Nobuya, Ishida, Takeshi, Kato, Junichi, Kishi, Minoru, Kishino, Yoshinobu, Kobayashi, Kazuki, Kouyama, Kunichi, Kuroda, Yujiro, Kuwahata, So, Matsumoto, Nanae, Noma, Hisashi, Ogino, Jun, Ogura, Masahito, Ohishi, Mitsuru, and Shimada, Hiroyuki

Abstract

Background: The aim of the Japan‐Multidomain Intervention Trial for Prevention of Dementia in Older Adults with Diabetes (J‐MIND‐Diabetes) was to examine the efficacy of multi‐domain intervention in prevention of cognitive decline in older adults with type 2 diabetes and mild cognitive impairment (MCI). Method: The J‐MIND‐Diabetes is an 18‐month, multi‐centered, randomized controlled trial. Outpatients with type 2 diabetes aged 70‐85 years with MCI were recruited and randomized into multi‐domain intervention (management of metabolic and vascular risk factors, physical exercise, nutritional guidance, and promotion of social participation) and control groups (general instructions on dementia prevention) at a 1:1 allocation ratio using the stratified permuted‐block randomization methods. The primary outcome was a change from baseline to 18‐month follow‐up in a global composite score combining several neuropsychological tests, which include the MoCA‐J, the MMSE, the Rey‐Osterrieth Complex Figure Test (ROCFT), delayed recall test of a 10‐word list, the Digit Span, the Trail Making Test, the Digit Symbol Substitution Test, and the Letter Word Fluency Test. Result: Between March 13, 2019, and May 8, 2020, 361 patients were screened and 154 were randomly assigned to the multi‐domain intervention group (n = 81) or control group (n = 73). 110 (71%) participants completed the trial. The full analysis set included 136 patients. In the primary efficacy analysis, there was no significant differences in the change of composite score from baseline to 18‐month follow‐up between the intervention group and the control group (mean difference 0.066 [95% CI ‐0.089 to 0.222]). In the analysis for each neuropsychological test, scores of immediate and delayed recall tests of the ROCFT in the intervention group significantly improved by a mean of 1.627 points and 1.793 points, respectively. The mean difference in the change of score of delayed recall test of the ROCFT between intervention group and control group was significant (mean difference 1.803 [95% CI 0.169 to 3.436]). In subgroup analyses, intervention effect on composite score was significant among patients with moderate to severe white matter hyperintensities (mean difference 0.351 [95% CI 0.088 to 0.614]). Conclusion: The multi‐domain intervention could improve memory function in older adults with type 2 diabetes and MCI. [ABSTRACT FROM AUTHOR]

Published
2023
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22. Supplementary Methods, Figures 1-3, Table 1 from Preclinical Efficacy and Safety Assessment of an Antibody–Drug Conjugate Targeting the c-RET Proto-Oncogene for Breast Carcinoma

Author

Nguyen, Minh, primary, Miyakawa, Shuichi, primary, Kato, Junichi, primary, Mori, Toshiyuki, primary, Arai, Toshimitsu, primary, Armanini, Mark, primary, Gelmon, Karen, primary, Yerushalmi, Rinat, primary, Leung, Samuel, primary, Gao, Dongxia, primary, Landes, Gregory, primary, Haak-Frendscho, Mary, primary, Elias, Kathleen, primary, and Simmons, Andrew D., primary

Published
2023
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41. Intraluminal diamond‐like carbon coating with anti‐adhesion and anti‐biofilm effects for uropathogens: A novel technology applicable to urinary catheters

Author

Watari, Shogo, primary, Wada, Koichiro, additional, Araki, Motoo, additional, Sadahira, Takuya, additional, Ousaka, Daiki, additional, Oozawa, Susumu, additional, Nakatani, Tatsuyuki, additional, Imai, Yuichi, additional, Kato, Junichi, additional, Kariyama, Reiko, additional, Watanabe, Toyohiko, additional, and Nasu, Yasutomo, additional

Published
2021
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42. The Multi-Domain Intervention Trial in Older Adults With Diabetes Mellitus for Prevention of Dementia in Japan: Study Protocol for a Multi-Center, Randomized, 18-Month Controlled Trial

Author

Sugimoto, Taiki, primary, Araki, Atsushi, additional, Fujita, Hiroki, additional, Honda, Keiko, additional, Inagaki, Nobuya, additional, Ishida, Takeshi, additional, Kato, Junichi, additional, Kishi, Minoru, additional, Kobayashi, Kazuki, additional, Kouyama, Kunichi, additional, Noma, Hisashi, additional, Ohishi, Mitsuru, additional, Satoh-Asahara, Noriko, additional, Shimada, Hiroyuki, additional, Sugimoto, Kazuhiro, additional, Suzuki, Susumu, additional, Takeya, Yasushi, additional, Tamura, Yoshiaki, additional, Tokuda, Haruhiko, additional, Umegaki, Hiroyuki, additional, Watada, Hirotaka, additional, Yamada, Yuichiro, additional, and Sakurai, Takashi, additional

Published
2021
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