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12 results on '"Katkeviciute, Egle"'

1. Abstract 4038: Discovery of potent and selective inhibitors of the protein tyrosine phosphatases PTPN2 and PTPN1 to trigger anti-tumor immunity through sensitization of tumor cells and activation of immune cells

Author

Pervolaraki, Kalliopi, primary, Katkeviciute, Egle, additional, Lambin, Dominique, additional, Boland, Sandro, additional, Kilonda, Amuri, additional, Pericolle, Vincent, additional, Nijs, Marnik, additional, Haeck, Wanda, additional, Metzger, Kristine, additional, Klaassen, Hugo, additional, Marchand, Arnaud, additional, Chaltin, Patrick, additional, Versele, Matthias, additional, Spalinger, Marianne, additional, and Scharl, Michael, additional

Published
2023
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2. Spermidine Ameliorates Colitis via Induction of Anti-Inflammatory Macrophages and Prevention of Intestinal Dysbiosis

Author

Niechcial, Anna, primary, Schwarzfischer, Marlene, additional, Wawrzyniak, Marcin, additional, Atrott, Kirstin, additional, Laimbacher, Andrea, additional, Morsy, Yasser, additional, Katkeviciute, Egle, additional, Häfliger, Janine, additional, Westermann, Patrick, additional, Akdis, Cezmi A, additional, Scharl, Michael, additional, and Spalinger, Marianne R, additional

Published
2023
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3. Protein tyrosine phosphatase nonreceptor type 2 controls colorectal cancer development

Author

Katkeviciute, Egle, Hering, Larissa, Montalban-Arques, Ana, Busenhart, Philipp, Schwarzfischer, Marlene, Manzini, Roberto, Conde, Javier, Atrott, Kirstin, Lang, Silvia, Rogler, Gerhard, Naschberger, Elisabeth, Schellerer, Vera S., Sturzl, Michael, Rickenbacher, Andreas, Turina, Matthias, Weber, Achim, Leibl, Sebastian, Leventhal, Gabriel E., Levesque, Mitchell, Boyman, Onur, Scharl, Michael, and Spalinger, Marianne R.

Subjects
Enzymes -- Regulation, Colorectal cancer -- Genetic aspects -- Development and progression -- Care and treatment, Esterases -- Health aspects, Immunotherapy -- Methods -- Patient outcomes, Health care industry
Abstract

Protein tyrosine phosphatase nonreceptor type 2 (PTPN2) recently emerged as a promising cancer immunotherapy target. We set out to investigate the functional role of PTPN2 in the pathogenesis of human colorectal carcinoma (CRC), as its role in immune-silent solid tumors is poorly understood. We demonstrate that in human CRC, increased PTPN2 expression and activity correlated with disease progression and decreased immune responses in tumor tissues. In particular, stage II and III tumors displayed enhanced PTPN2 protein expression in tumor-infiltrating T cells, and increased PTPN2 levels negatively correlated with expression of PD-1, CTLA4, STAT1, and granzyme A. In vivo, T cell- and DC-specific PTPN2 deletion reduced tumor burden in several CRC models by promoting [CD44.sup.+] effector/memory T cells, as well as [CD8.sup.+] T cell infiltration and cytotoxicity in the tumor. In direct relevance to CRC treatment, T cell-specific PTPN2 deletion potentiated anti-PD-1 efficacy and induced antitumor memory formation upon tumor rechallenge in vivo. Our data suggest a role for PTPN2 in suppressing antitumor immunity and promoting tumor development in patients with CRC. Our in vivo results identify PTPN2 as a key player in controlling the immunogenicity of CRC, with the strong potential to be exploited for cancer immunotherapy., Introduction Colorectal carcinoma (CRC) is the third most frequent malignancy and the second leading cause of cancer-related deaths worldwide (1, 2). In 2018, more than 1.8 million patients were newly [...]

Published
2021
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4. Inhibition of integrin αvβ6 sparks T-cell antitumor response and enhances immune checkpoint blockade therapy in colorectal cancer

Author

Busenhart, Philipp, primary, Montalban-Arques, Ana, additional, Katkeviciute, Egle, additional, Morsy, Yasser, additional, Van Passen, Chiara, additional, Hering, Larissa, additional, Atrott, Kirstin, additional, Lang, Silvia, additional, Garzon, Jesus Francisco Glaus, additional, Naschberger, Elisabeth, additional, Hartmann, Arndt, additional, Rogler, Gerhard, additional, Stürzl, Michael, additional, Spalinger, Marianne Rebecca, additional, and Scharl, Michael, additional

Published
2022
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5. Commensal Clostridiales strains mediate effective anti-cancer immune response against solid tumors

Author

Montalban-Arques, Ana, primary, Katkeviciute, Egle, additional, Busenhart, Philipp, additional, Bircher, Anna, additional, Wirbel, Jakob, additional, Zeller, Georg, additional, Morsy, Yasser, additional, Borsig, Lubor, additional, Glaus Garzon, Jesus F., additional, Müller, Anne, additional, Arnold, Isabelle C., additional, Artola-Boran, Mariela, additional, Krauthammer, Michael, additional, Sintsova, Anna, additional, Zamboni, Nicola, additional, Leventhal, Gabriel E., additional, Berchtold, Laura, additional, de Wouters, Tomas, additional, Rogler, Gerhard, additional, Baebler, Katharina, additional, Schwarzfischer, Marlene, additional, Hering, Larissa, additional, Olivares-Rivas, Ivan, additional, Atrott, Kirstin, additional, Gottier, Claudia, additional, Lang, Silvia, additional, Boyman, Onur, additional, Fritsch, Ralph, additional, Manz, Markus G., additional, Spalinger, Marianne R., additional, and Scharl, Michael, additional

Published
2021
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6. Macrophages Compensate for Loss of Protein Tyrosine Phosphatase N2 in Dendritic Cells to Protect from Elevated Colitis

Author

Hering, Larissa, primary, Katkeviciute, Egle, additional, Schwarzfischer, Marlene, additional, Niechcial, Anna, additional, Riggs, Julianne B., additional, Wawrzyniak, Marcin, additional, Atrott, Kirstin, additional, van de Sande, Marnix, additional, Lang, Silvia, additional, Becher, Burkhard, additional, Rogler, Gerhard, additional, Scharl, Michael, additional, and Spalinger, Marianne R., additional

Published
2021
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7. Protein tyrosine phosphatase non-receptor type 2 controls colorectal cancer development

Author

Katkeviciute, Egle, Hering, Larissa, Montalban-Arques, Ana, Busenhart, Philipp, Schwarzfischer, Marlene, Manzini, Roberto, Conde, Javier, Atrott, Kirstin, Lang, Silvia, Rogler, Gerhard, Naschberger, Elisabeth, Schellerer, Vera S, Stürzl, Michael, Rickenbacher, Andreas, Turina, Matthias, Weber, Achim, Leibl, Sebastian, Leventhal, Gabriel E, Levesque, Mitchell Paul, Boyman, Onur, Scharl, Michael, Spalinger, Marianne R, and University of Zurich

Subjects
10219 Clinic for Gastroenterology and Hepatology, 10049 Institute of Pathology and Molecular Pathology, 10033 Clinic for Immunology, 610 Medicine & health, 10217 Clinic for Visceral and Transplantation Surgery
Published
2021
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8. Macrophages Compensate for Loss of Protein Tyrosine Phosphatase N 2 in Dendritic Cells to Protect from Elevated Colitis

Author

Hering, Larissa, Katkeviciute, Egle, Schwarzfischer, Marlene, Niechcial, Anna, Riggs, Julianne B, Wawrzyniak, Marcin, Atrott, Kirstin, van de Sande, Marnix, Lang, Silvia, Becher, Burkhard, Rogler, Gerhard, Scharl, Michael, Spalinger, Marianne R, University of Zurich, and Scharl, Michael

Subjects
10219 Clinic for Gastroenterology and Hepatology, 1503 Catalysis, 1604 Inorganic Chemistry, 1312 Molecular Biology, 1706 Computer Science Applications, 1607 Spectroscopy, 610 Medicine & health, 10263 Institute of Experimental Immunology, 1606 Physical and Theoretical Chemistry, 1605 Organic Chemistry
Published
2021
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9. Titanium Dioxide Presents a Different Profile in Dextran Sodium Sulphate-Induced Experimental Colitis in Mice Lacking the IBD Risk Gene Ptpn2 in Myeloid Cells

Author

Conde, Javier, primary, Schwarzfischer, Marlene, additional, Katkeviciute, Egle, additional, Häfliger, Janine, additional, Niechcial, Anna, additional, Brillant, Nathalie, additional, Manzini, Roberto, additional, Bäbler, Katharina, additional, Atrott, Kirstin, additional, Lang, Silvia, additional, and Scharl, Michael, additional

Published
2021
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10. Protein Tyrosine Phosphatase Non-Receptor Type 2 Function in Dendritic Cells Is Crucial to Maintain Tissue Tolerance

Author

Hering, Larissa, primary, Katkeviciute, Egle, additional, Schwarzfischer, Marlene, additional, Busenhart, Philipp, additional, Gottier, Claudia, additional, Mrdjen, Dunja, additional, Komuczki, Juliana, additional, Wawrzyniak, Marcin, additional, Lang, Silvia, additional, Atrott, Kirstin, additional, Becher, Burkhard, additional, Rogler, Gerhard, additional, Scharl, Michael, additional, and Spalinger, Marianne R., additional

Published
2020
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11. Su1029 – Tio2 Nanoparticles Abrogate the Protective Effect of the Autoimmunity-Associated PTPN22 R619W Variant During Acute DSS Colitis

Author

Schwarzfischer, Marlene, primary, Hering, Larissa, additional, Katkeviciute, Egle, additional, Niechcial, Anna, additional, Atrott, Kirstin, additional, Baebler, Katharina, additional, Busenhart, Philipp, additional, Rogler, Gerhard, additional, Scharl, Michael M., additional, and Spalinger, Marianne, additional

Published
2019
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12. Macrophages Compensate for Loss of Protein Tyrosine Phosphatase N 2 in Dendritic Cells to Protect from Elevated Colitis.

Author

Hering L, Katkeviciute E, Schwarzfischer M, Niechcial A, Riggs JB, Wawrzyniak M, Atrott K, van de Sande M, Lang S, Becher B, Rogler G, Scharl M, and Spalinger MR

Subjects
Animals, Colitis pathology, Dextran Sulfate adverse effects, Disease Models, Animal, Disease Susceptibility, Intestinal Mucosa immunology, Intestinal Mucosa metabolism, Intestinal Mucosa pathology, Mice, Mice, Transgenic, Phosphorylation, Protein Tyrosine Phosphatase, Non-Receptor Type 2 genetics, Protein Tyrosine Phosphatase, Non-Receptor Type 2 metabolism, STAT1 Transcription Factor metabolism, Severity of Illness Index, Signal Transduction, T-Lymphocyte Subsets immunology, T-Lymphocyte Subsets metabolism, T-Lymphocyte Subsets pathology, Colitis etiology, Colitis metabolism, Dendritic Cells immunology, Dendritic Cells metabolism, Macrophages immunology, Macrophages metabolism, Protein Tyrosine Phosphatase, Non-Receptor Type 2 deficiency
Abstract

Protein tyrosine phosphatase nonreceptor type 2 (PTPN2) plays a critical role in the pathogenesis of inflammatory bowel diseases (IBD). Mice lacking PTPN2 in dendritic cells (DCs) develop skin and liver inflammation by the age of 22 weeks due to a generalized loss of tolerance leading to uncontrolled immune responses. The effect of DC-specific PTPN2 loss on intestinal health, however, is unknown. The aim of this study was to investigate the DC-specific role of PTPN2 in the intestine during colitis development. PTPN2 fl/fl xCD11c Cre mice were subjected to acute and chronic DSS colitis as well as T cell transfer colitis. Lamina propria immune cell populations were analyzed using flow cytometry. DC-specific PTPN2 deletion promoted infiltration of B and T lymphocytes, macrophages, and DCs into the lamina propria of unchallenged mice and elevated Th1 abundance during acute DSS colitis, suggesting an important role for PTPN2 in DCs in maintaining intestinal immune cell homeostasis. Surprisingly, those immune cell alterations did not translate into increased colitis susceptibility in acute and chronic DSS-induced colitis or T cell transfer colitis models. However, macrophage depletion by clodronate caused enhanced colitis severity in mice with a DC-specific loss of PTPN2. Loss of PTPN2 in DCs affects the composition of lamina propria lymphocytes, resulting in increased infiltration of innate and adaptive immune cells. However, this did not result in an elevated colitis phenotype, likely because increased infiltration of macrophages in the intestine upon loss of PTPN2 loss in DCs can compensate for the inflammatory effect of PTPN2-deficient DCs.

Published
2021
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