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From its beginning in 1885, the Hull House was beacon for social progress and urban reform. Founders Jane Addams and Ellen Gates Starr recruited talented, passionate partners from diverse fields to address issues from street sanitation to education in Chicago’s immigrant communities. Among residents’ many projects, their involvement in the “social hygiene” movement for sex education and contraception is perhaps the least recognised, in part because the Hull House did not save materials directly related to these services. As a result, the professional activities of Hull House residents Drs Rachelle Yarros and Alice Hamilton reveal a productive relationship between the Hull House and the social hygiene movement. Part of their critical work was to dismantle the cultural association of contraceptives and sex education with “fallen women” and reframe these services as necessities for maternal health. The papers of their professional organisations chronicle their delicate efforts to challenge assumptions about reproductive healthcare while preserving Victorian ideals about sex as a private, procreative endeavour strictly between married, monogamous people. Rachelle Yarros was particularly active, producing a dearth of literature on sexual health, teaching classes on the subject, and overseeing the opening of Chicago’s first public birth control clinics. Each of these advancements, including the birth control clinic, was available on Hull House grounds. By capitalising on the financial and medical resources available to them as physicians and reformers, Yarros and Hamilton achieved significant gains in women’s healthcare and initiated a national conversation about sexual health as a human right.

The worldwide prevalence of diabetes has reached 8.5% among adults, and this is characterised by elevated glucose concentrations and failing insulin secretion. Furthermore, most people with type 2 diabetes are either obese or overweight, with the associated dyslipidaemia contributing to the development of insulin resistance and increased cardiovascular risk. Here we incubated INS-1 pancreatic β-cells for 72 h in RPMI-1640 media, or media supplemented with 28 mM glucose, 200 µM palmitic acid, and 200 µM oleic acid as a cellular model of diabetic glucolipotoxicity. Illumina HiSeq gene expression analysis showed the trace amine-associated receptor (TAAR) family to be among the most highly downregulated by glucolipotoxicity. Importantly, MetaCore integrated knowledge database, from Clarivate Analytics, indicated potential TAAR impact on insulin secretion through adenylyl cyclase signalling pathways. We therefore investigated the effect of TAAR ligands on cAMP signalling and insulin secretion, and found that only the branch of the TAAR family tree that is activated by isopentylamine, 2-phenylethylamine, p-tyramine, and agmatine significantly increased intracellular cAMP and resulted in increased insulin secretion from INS-1 cells and primary mouse islets under normal conditions. Crucially however, this enhancement was not evident when the receptor family was downregulated by glucolipotoxic conditions. This data indicates that a subset of TAARs are regulators of insulin secretion in pancreatic β-cells, and that their downregulation contributes to glucolipotoxic inhibition of insulin secretion. As such they may be potential targets for treatment of type 2 diabetes.