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Background The potential benefit of additional breast cancer screening examinations in moderate risk patients (patients with a history of breast cancer in one or two family members) remains unclear. Methods A large population-based case–control study on breast cancer in postmenopausal women in Germany recruited 2002–2005 (3813 cases and 7341 age-matched controls) was used to assess the association of family history with breast cancer risk. Analysis of family history, participation in screening procedures, and tumor size regarding prognosis in patients was based on follow-up data until 2015. Results A first degree family history of breast cancer was associated with higher breast cancer risk (OR 1.39, p 10 mammograms (MG) (42.7% vs. 24.9%, p, Highlights • Large case-control study with data about family history of breast cancer of 3813 cases and 7341controls and follow-up data. • Breast cancer patients with a first degree family history of breast cancer had a higher number of performed mammograms. • Breast cancer patients with first degree family history of breast cancer also had a higher rate of imaging-detected tumors. • Patients with a positive family history of breast cancer were more likely to have a smaller tumor size at diagnosis. • Imaging-assisted tumor detection was associated with better overall survival.

Background Physical activity (PA) before and after breast cancer diagnosis has been reported to be associated with lower mortality. However, whether changes in the activity after diagnosis impact prognosis is unclear and has not received much attention. This study aimed to examine pre- to postdiagnosis leisure-time PA and breast cancer prognosis. Methods We used data from the MARIE study, a prospective population-based patient cohort study of 3813 postmenopausal breast cancer patients, aged 50–74 at diagnosis, recruited from 2002 to 2005, re-interviewed in 2009, and followed up until June 2015. Prediagnosis PA was assessed at recruitment; postdiagnosis PA was assessed at re-interview in 2009. To examine pre- to postdiagnosis change in PA, women were categorized by pre- and postdiagnosis PA using a cut-off of 7.5 MET-h/week for meeting PA recommendations and combined into four groups: insufficiently active, increasingly active, decreasingly active, and sufficiently active. Cox regression models with delayed entry were used to assess associations between pre- to postdiagnosis patterns of PA and overall mortality (OM), breast cancer mortality (BCM), and recurrence-free survival (RFS). Additional analyses of pre- and postdiagnosis PA (no activity (reference), low activity, sufficient activity) with cancer outcomes, such as using a time-dependent model, were performed. In total, 2042 patients were included in the analyses. Results There were 206 deaths (114 from breast cancer) after a median follow-up time of 6.0 years after the 2009 interview. Compared to insufficiently active women, increasingly active women were at lower risk of OM, BCM, and RFS (HR (95%CI) of 0.50 (0.31–0.82), 0.54 (0.30–1.00), 0.58 (0.40–0.84), respectively). In sufficiently active women, associations for OM (0.75 (0.48–1.15)), BCM (0.61 (0.33–1.13)), and RFS 0.80 (0.57–1.14)) were similar to increasingly active women but attenuated, and decreasingly active women were not at lower risk for OM (0.91 (0.61–1.36)), BCM (0.80 (0.45–1.42)), and RFS (1.04 (0.76–1.43)). In time-dependent analyses, sufficient activity vs. no activity was associated with better OM (0.73 (0.57–0.93)), BCM (0.64 (0.46–0.89)), and RFS (0.82 (0.68–0.99)). Low activity was not significantly associated with prognosis. Conclusion Our data support benefits for breast cancer prognosis in being physically active pre- and postdiagnosis particularly for women who were insufficiently active prediagnosis.

Background There is a paucity of information on the prevalence of dietary supplement use in breast cancer survivors. Only a few studies have examined the impact of dietary supplements, particularly antioxidants, on breast cancer prognosis and the results are inconclusive. Objective We examined pre- and postdiagnosis use of supplements in postmenopausal breast cancer survivors in Germany and investigated associations between postdiagnosis use of antioxidants and other supplements, and prognosis (total and breast cancer mortality, and recurrence-free survival) both overall and in women who received chemotherapy and radiation therapy. Design Data from 2223 postmenopausal women diagnosed with nonmetastatic breast cancer from the population-based Mamma Carcinoma Risk Factor Investigation (MARIE) study were used. Women were interviewed at recruitment in 2002-2005 and again in 2009 and followed-up until 30 June 2015. Multivariate Cox regression analysis was used to estimate HRs and corresponding 95% CIs. Results Pre- and postdiagnosis supplement use was reported by 36% and 45% of the women, respectively. There were 240 deaths (134 from breast cancer) and 200 breast cancer recurrences after a median follow-up time of 6.0 y after the 2009 re-interview. After adjusting for relevant confounders, concurrent antioxidant use with chemotherapy or radiation therapy among 1940 women was associated with increased risk of total mortality (HR: 1.64; 95% CI: 1.01, 2.66) and worsened recurrence-free survival (HR: 1.84; 95% CI: 1.26, 2.68). Overall postdiagnosis supplement use was not associated with breast cancer prognosis. Conclusions Antioxidant use during chemotherapy or radiation therapy was associated with worsened breast cancer prognosis in postmenopausal women. There was no overall association between postdiagnosis supplement use and breast cancer prognosis. Results from our study align with the current recommendation to possibly avoid the use of antioxidants during chemotherapy or radiation therapy.

Stroke frequently results in motor impairment. Motor imagery (MI), the mental practice of movements, has been suggested as a promising complement to other therapeutic approaches facilitating motor rehabilitation. Of particular potential is the combination of MI with neurofeedback (NF). However, MI NF protocols have been largely optimized only in younger healthy adults, although strokes occur more frequently in older adults. The present study examined the influence of age on the neural correlates of MI supported by electroencephalogram (EEG)-based NF and on the neural correlates of motor execution. We adopted a multimodal neuroimaging framework focusing on EEG-derived event-related desynchronization (ERD%) and oxygenated (HbO) and deoxygenated hemoglobin (HbR) concentrations simultaneously acquired using functional near-infrared spectroscopy (fNIRS). ERD%, HbO concentration and HbR concentration were compared between younger (mean age: 24.4 years) and older healthy adults (mean age: 62.6 years). During MI, ERD% and HbR concentration were less lateralized in older adults than in younger adults. The lateralization-by-age interaction was not significant for movement execution. Moreover, EEG-based NF was related to an increase in task-specific activity when compared to the absence of feedback in both older and younger adults. Finally, significant modulation correlations were found between ERD% and hemodynamic measures despite the absence of significant amplitude correlations. Overall, the findings suggest a complex relationship between age and movement-related activity in electrophysiological and hemodynamic measures. Our results emphasize that the age of the actual end-user should be taken into account when designing neurorehabilitation protocols.

Aim: Recreational physical activity (PA) both before and after a breast cancer diagnosis has been reported to be associated with lower total mortality. Whether there is benefit in changing PA levels between pre- and post-diagnosis is unclear and has not received much attention. This study aimed to examine changes in recreational PA and overall mortality (OM) and breast cancer-specific mortality (BCSM). Methods: We used data from the MARIE (Mamma Carcinoma Risk factor Investigation) study, a prospective population-based patient cohort study conducted in Germany, where 3813 breast cancer patients, aged 50-70 at diagnosis, were recruited from 2002-2005 and followed-up with re-interview in 2009 (FUP1) and for vital status until June 30, 2015. Based on median cut-points, women were categorized by their PA behavior pre- and post-diagnosis and combined to create four groups: pre-diagnosis low/post-diagnosis low, pre-diagnosis low/post-diagnosis high, pre-diagnosis high/post-diagnosis low, pre-diagnosis high/post-diagnosis high. Cox proportional hazards regression models with delayed-entry were used to assess the associations between change in recreational physical activity, and OM and BCSM, adjusting for age, menopausal status, and prognostic factors. Those in the pre-diagnosis low/post-diagnosis low group served as the reference. Results: A total of 2,066 patients were included in the analysis. There were 139 deaths (54 from breast cancer) over a median follow-up time of 11.6 years. Median recreational PA levels at pre-diagnosis and post-diagnosis were 3.6 MET-hr/week and 0 MET-hr/week, respectively. Compared to women who had low recreational PA levels at pre-diagnosis and post-diagnosis, women who had low recreational PA levels at pre-diagnosis and high PA levels at post-diagnosis had lower risk of OM (HR 0.6 (95%CI 0.4-1.0)), and women who had high PA levels at pre-diagnosis and maintained high PA levels at post-diagnosis also had lower risk of OM (HR 0.6 (0.8-0.9)). There was no association between changes in recreational PA and OM for women who had high PA levels at pre-diagnosis and low PA levels at post-diagnosis (HR 0.8 (0.5-1.3)). There were also no statistically significant associations between changes in recreational PA and BCSM (compared to low/low, HRs for low/high 0.8 (0.4-1.7), high/low 0.9 (0.4-1.9), and high/high 0.7 (0.3-1.3)). Conclusion: Our study suggests that there may be benefits in increasing recreational PA after diagnosis of a breast cancer even for women who were not particularly physically active pre-diagnosis. Citation Format: Audrey Y. Jung, Sabine Behrens, Kathrin Thoene, Martina Schmidt, Karen Steindorf, Jenny Chang-Claude. Changes in recreational physical activity and prognosis in breast cancer survivors [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2018; 2018 Apr 14-18; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2018;78(13 Suppl):Abstract nr 3009.

1566Background: Accumulating evidence implicates inflammation and diet in cancer. Our aim was to investigate the associations between levels of 16 circulating biomarkers,dietary inflammation index ...