14 results on '"Katharina Zweig"'
Search Results
2. Global microRNA level regulation of EGFR‐driven cell‐cycle protein network in breast cancer
- Author
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Stefan Uhlmann, Heiko Mannsperger, Jitao David Zhang, Emöke‐Ágnes Horvat, Christian Schmidt, Moritz Küblbeck, Frauke Henjes, Aoife Ward, Ulrich Tschulena, Katharina Zweig, Ulrike Korf, Stefan Wiemann, and Özgür Sahin
- Subjects
breast cancer ,EGFR signaling ,microRNA ,miRNA–protein interaction network ,network analysis ,Biology (General) ,QH301-705.5 ,Medicine (General) ,R5-920 - Abstract
Abstract The EGFR‐driven cell‐cycle pathway has been extensively studied due to its pivotal role in breast cancer proliferation and pathogenesis. Although several studies reported regulation of individual pathway components by microRNAs (miRNAs), little is known about how miRNAs coordinate the EGFR protein network on a global miRNA (miRNome) level. Here, we combined a large‐scale miRNA screening approach with a high‐throughput proteomic readout and network‐based data analysis to identify which miRNAs are involved, and to uncover potential regulatory patterns. Our results indicated that the regulation of proteins by miRNAs is dominated by the nucleotide matching mechanism between seed sequences of the miRNAs and 3′‐UTR of target genes. Furthermore, the novel network‐analysis methodology we developed implied the existence of consistent intrinsic regulatory patterns where miRNAs simultaneously co‐regulate several proteins acting in the same functional module. Finally, our approach led us to identify and validate three miRNAs (miR‐124, miR‐147 and miR‐193a‐3p) as novel tumor suppressors that co‐target EGFR‐driven cell‐cycle network proteins and inhibit cell‐cycle progression and proliferation in breast cancer.
- Published
- 2012
- Full Text
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3. Using Assurance Cases to assure the fulfillment of non-functional requirements of AI-based systems - Lessons learned
- Author
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Marc P. Hauer, Lena Müller-Kress, Gertraud Leimüller, and Katharina Zweig
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- 2023
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4. A Custom Hardware Architecture for the Link Assessment Problem
- Author
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André Chinazzo, Christian De Schryver, Katharina Zweig, and Norbert Wehn
- Abstract
Heterogeneous accelerator enhanced computing architectures are a common solution in embedded computing, mainly due to the constraints in energy and power efficiency. Such accelerator enhanced systems dispatch data- and computing-intensive tasks to specialized, optimized and thus efficient hardware units, leaving most control flow tasks for the more generic but less efficient central processing units (CPUs). Nowadays, also high-performance computing (HPC) systems are becoming more heterogeneous by incorporating accelerators into the computing nodes.In this chapter, we introduce the concept of heterogeneous computing and present the design of a hardware accelerator for solving the Link Assessment (LA) problem, in introduced Chapter 3. The hardware accelerator integrates its main dedicated processing units with a customized cache design and light-weight data path. We provide detailed area, energy, and timing results for a 28 nm application specific integrated circuit (ASIC) process and DDR3 memory devices. Compared to an CPU-based cluster, our proposed solution uses 38x less memory and is 1030x more energy efficient for processing a users-movies dataset with half a million edges.
- Published
- 2022
- Full Text
- View/download PDF
5. Increasing the Sampling Efficiency for the Link Assessment Problem
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André Chinazzo, Christian De Schryver, Katharina Zweig, and Norbert Wehn
- Abstract
Complex graphs are at the heart of today’s big data challenges like recommendation systems, customer behavior modeling, or incident detection systems. One reoccurring task in these fields is the extraction of network motifs, which are subgraphs that are reoccurring and statistically significant. To assess the statistical significance of their occurrence, the observed values in the real network need to be compared to their expected value in a random graph model.In this chapter, we focus on the so-called Link Assessment (LA) problem, in particular for bipartite networks. Lacking closed-form solutions, we require stochastic Monte Carlo approaches that raise the challenge of finding appropriate metrics for quantifying the quality of results (QoR) together with suitable heuristics that stop the computation process if no further increase in quality is expected. We provide investigation results for three quality metrics and show that observing the right metrics reveals so-called phase transitions that can be used as a reliable basis for such heuristics. Finally, we propose a heuristic that has been evaluated with real-word datasets, providing a speedup of $$15.4\times $$ 15.4 × over previous approaches.
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- 2022
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6. Diversity in News Recommendation
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Abraham Bernstein, Claes de Vreese, Natali Helberger, Wolfgang Schulz, Katharina Zweig, Christian Baden, Beam, Michael A., Hauer, Marc P., Lucien Heitz, Pascal Jürgens, Christian Katzenbach, Benjamin Kille, Beate Klimkiewicz, Wiebke Loosen, Judith Moeller, Goran Radanovic, Guy Shani, Nava Tintarev, Suzanne Tolmeijer, Wouter van Atteveldt, Sanne Vrijenhoek, Theresa Zueger, Communication Science, Network Institute, and Communication Choices, Content and Consequences (CCCC)
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FOS: Computer and information sciences ,Diversity ,Human-centered computing → Empirical studies in HCI ,Information systems → Digital libraries and archives ,News ,Information systems → Web services ,Applied computing → Economics ,diversity ,Computer Science - Computers and Society ,Applied computing → Sociology ,Human-centered computing → HCI theory, concepts and models ,SDG 17 - Partnerships for the Goals ,H.3.3 ,Computers and Society (cs.CY) ,Information systems → Information retrieval diversity ,Recommender systems ,Applied computing → Psychology ,recommender systems - Abstract
News diversity in the media has for a long time been a foundational and uncontested basis for ensuring that the communicative needs of individuals and society at large are met. Today, people increasingly rely on online content and recommender systems to consume information challenging the traditional concept of news diversity. In addition, the very concept of diversity, which differs between disciplines, will need to be re-evaluated requiring an interdisciplinary investigation, which requires a new level of mutual cooperation between computer scientists, social scientists, and legal scholars. Based on the outcome of a interdisciplinary workshop, we have the following recommendations, directed at researchers, funders, legislators, regulators, and the media industry: - Conduct interdisciplinary research on news recommenders and diversity. - Create a safe harbor for academic research with industry data. - Strengthen the role of public values in news recommenders. - Create a meaningful governance framework for news recommenders. - Fund a joint lab to spearhead the needed interdisciplinary research, boost practical innovation, develop reference solutions, and transfer insights into practice., DagMan, Volume 9, Issue 1, pages 43-61
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- 2021
- Full Text
- View/download PDF
7. Diversity in News Recommendation (Dagstuhl Perspectives Workshop 19482)
- Author
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Abraham Bernstein and Claes de Vreese and Natali Helberger and Wolfgang Schulz and Katharina Zweig and Christian Baden and Michael A. Beam and Marc P. Hauer and Lucien Heitz and Pascal Jürgens and Christian Katzenbach and Benjamin Kille and Beate Klimkiewicz and Wiebke Loosen and Judith Moeller and Goran Radanovic and Guy Shani and Nava Tintarev and Suzanne Tolmeijer and Wouter van Atteveldt and Sanne Vrijenhoek and Theresa Zueger, Bernstein, Abraham, de Vreese, Claes, Helberger, Natali, Schulz, Wolfgang, Zweig, Katharina, Baden, Christian, Beam, Michael A., Hauer, Marc P., Heitz, Lucien, Jürgens, Pascal, Katzenbach, Christian, Kille, Benjamin, Klimkiewicz, Beate, Loosen, Wiebke, Moeller, Judith, Radanovic, Goran, Shani, Guy, Tintarev, Nava, Tolmeijer, Suzanne, van Atteveldt, Wouter, Vrijenhoek, Sanne, Zueger, Theresa, Abraham Bernstein and Claes de Vreese and Natali Helberger and Wolfgang Schulz and Katharina Zweig and Christian Baden and Michael A. Beam and Marc P. Hauer and Lucien Heitz and Pascal Jürgens and Christian Katzenbach and Benjamin Kille and Beate Klimkiewicz and Wiebke Loosen and Judith Moeller and Goran Radanovic and Guy Shani and Nava Tintarev and Suzanne Tolmeijer and Wouter van Atteveldt and Sanne Vrijenhoek and Theresa Zueger, Bernstein, Abraham, de Vreese, Claes, Helberger, Natali, Schulz, Wolfgang, Zweig, Katharina, Baden, Christian, Beam, Michael A., Hauer, Marc P., Heitz, Lucien, Jürgens, Pascal, Katzenbach, Christian, Kille, Benjamin, Klimkiewicz, Beate, Loosen, Wiebke, Moeller, Judith, Radanovic, Goran, Shani, Guy, Tintarev, Nava, Tolmeijer, Suzanne, van Atteveldt, Wouter, Vrijenhoek, Sanne, and Zueger, Theresa
- Abstract
News diversity in the media has for a long time been a foundational and uncontested basis for ensuring that the communicative needs of individuals and society at large are met. Today, people increasingly rely on online content and recommender systems to consume information challenging the traditional concept of news diversity. In addition, the very concept of diversity, which differs between disciplines, will need to be re-evaluated requiring an interdisciplinary investigation, which requires a new level of mutual cooperation between computer scientists, social scientists, and legal scholars. Based on the outcome of a interdisciplinary workshop, we have the following recommendations, directed at researchers, funders, legislators, regulators, and the media industry: - Conduct interdisciplinary research on news recommenders and diversity. - Create a safe harbor for academic research with industry data. - Strengthen the role of public values in news recommenders. - Create a meaningful governance framework for news recommenders. - Fund a joint lab to spearhead the needed interdisciplinary research, boost practical innovation, develop reference solutions, and transfer insights into practice.
- Published
- 2021
- Full Text
- View/download PDF
8. Fairness by awareness? On the inclusion of protected features in algorithmic decisions
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Hanna Hoffmann, Verena Vogt, Marc P. Hauer, and Katharina Zweig
- Subjects
Computer Networks and Communications ,Law ,General Business, Management and Accounting - Published
- 2022
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9. Collaborative Interactive Learning
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Albrecht Schmidt, Bernhard Sick, Anna Katharina Zweig, Sarah Oeste-Reiß, and Sven Tomforde
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0209 industrial biotechnology ,020901 industrial engineering & automation ,Multimedia ,Computer science ,0202 electrical engineering, electronic engineering, information engineering ,020201 artificial intelligence & image processing ,02 engineering and technology ,computer.software_genre ,Business studies ,computer ,Computer Science Applications ,Information Systems ,Interactive Learning - Published
- 2017
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10. Entertainment Computing and Serious Games : International GI-Dagstuhl Seminar 15283, Dagstuhl Castle, Germany, July 5-10, 2015, Revised Selected Papers
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Ralf Dörner, Stefan Göbel, Michael Kickmeier-Rust, Maic Masuch, Katharina Zweig, Ralf Dörner, Stefan Göbel, Michael Kickmeier-Rust, Maic Masuch, and Katharina Zweig
- Subjects
- Microcomputers, Application software, User interfaces (Computer systems), Human-computer interaction, Multimedia systems, Education—Data processing, Computer graphics
- Abstract
The aim of this book is to collect and to cluster research areas in the field of serious games and entertainment computing. It provides an introduction and gives guidance for the next generation of researchers in this field.The 18 papers presented in this volume, together with an introduction, are the outcome of a GI-Dagstuhl seminar which was held at Schloß Dagstuhl in July 2015.
- Published
- 2016
11. Socioinformatics - The Social Impact of Interactions Between Humans and IT
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Katharina Zweig, Wolfgang Neuser, Volkmar Pipek, Markus Rohde, Ingo Scholtes, Katharina Zweig, Wolfgang Neuser, Volkmar Pipek, Markus Rohde, and Ingo Scholtes
- Subjects
- Information science--Sociological aspects, Information technology--Social aspects
- Abstract
Socioinformatics is a new scientific approach to study the interactions between humans and IT. These proceedings are a collection of the contributions during a workshop of the Gesellschaft für Informatik (GI). Researchers in this emerging field discuss the main aspects of interactions between IT and humans with respect to; social connections, social changes, acceptance of IT and the social conditions affecting this acceptance, effects of IT on humans and in response changes of IT, structures of the society and the influence of IT on these structures, changes of metaphysics influenced by IT and the social context of a knowledge society.
- Published
- 2014
12. Socioinformatics - The Social Impact of Interactions between Humans and IT
- Author
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Markus Rohde, Wolfgang Neuser, Katharina Zweig, Volkmar Pipek, and Ingo Scholtes
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Knowledge society ,Social condition ,Field (Bourdieu) ,Social impact ,Social change ,Metaphysics ,Social environment ,Sociology ,Social science ,Epistemology - Abstract
Socioinformatics is a new scientific approach to study the interactions between humans and IT. These proceedings are a collection of the contributions during a workshop of the Gesellschaft fr Informatik (GI). Researchers in this emerging field discuss the main aspects of interactions between IT and humans with respect to; social connections, social changes, acceptance of IT and the social conditions affecting this acceptance, effects of IT on humans and in response changes of IT, structures of the society and the influence of IT on these structures, changes of metaphysics influenced by IT and the social context of a knowledge society.
- Published
- 2014
- Full Text
- View/download PDF
13. Algorithmics of Large and Complex Networks : Design, Analysis, and Simulation
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Jürgen Lerner, Dorothea Wagner, Katharina Zweig, Jürgen Lerner, Dorothea Wagner, and Katharina Zweig
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- Computer networks, Telecommunication--Traffic, Algorithms, Programming (Mathematics), Netzwerk--Gro€es System--Effizienter Algorithm, Netzwerk--Komplexes System--Effizienter Algori, Effizienter Algorithmus, Gro€es System, Komplexes System, Netzwerk
- Abstract
Networks play a central role in today's society, since many sectors employing information technology, such as communication, mobility, and transport - even social interactions and political activities - are based on and rely on networks. In these times of globalization and the current global financial crisis with its complex and nearly incomprehensible entanglements of various structures and its huge effect on seemingly unrelated institutions and organizations, the need to understand large networks, their complex structures, and the processes governing them is becoming more and more important. This state-of-the-art survey reports on the progress made in selected areas of this important and growing field, thus helping to analyze existing large and complex networks and to design new and more efficient algorithms for solving various problems on these networks since many of them have become so large and complex that classical algorithms are not sufficient anymore. This volume emerged from a research program funded by the German Research Foundation (DFG) consisting of projects focusing on the design of new discrete algorithms for large and complex networks. The 18 papers included in the volume present the results of projects realized within the program and survey related work. They have been grouped into four parts: network algorithms, traffic networks, communication networks, and network analysis and simulation.
- Published
- 2009
14. Drawing trees in a streaming model
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Maurizio Patrignani, Pietro Palladino, Antonios Symvonis, Giuseppe Di Battista, Walter Didimo, Marco Gaertler, Carla Binucci, Ulrik Brandes, Katharina Anna Zweig, Carla, Binucci, Ulrik, Brande, DI BATTISTA, Giuseppe, Walter, Didimo, Marco, Gaertler, Patrignani, Maurizio, Antonios, Symvoni, Katharina, Zweig, David Eppstein, Emden R. Gansner, C., Binucci, U., Brande, W., Didimo, M., Gaertler, P., Palladino, A., Symvoni, and K., Zweig
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Data stream ,Design of algorithms ,Graph algorithms ,Online algorithms ,Graph drawing ,Streaming ,Large graphs ,SPQR tree ,Theoretical computer science ,Computer science ,Graph Drawing ,Strength of a graph ,Theoretical Computer Science ,ComputingMilieux_COMPUTERSANDEDUCATION ,Large Graphs ,Competitive analysis ,Model of computation ,Grid ,Feedback arc set ,Computer Science Applications ,Graph bandwidth ,Signal Processing ,Graph (abstract data type) ,Image persistence ,Force-directed graph drawing ,ddc:004 ,MathematicsofComputing_DISCRETEMATHEMATICS ,Information Systems - Abstract
We pose a new visualization challenge, asking Graph Drawing algorithms to cope with the requirements of Streaming applications. In this model a source produces a graph one edge at a time. When an edge is produced, it is immediately drawn and its placement cannot be altered. The drawing has an image persistence, that controls the lifetime of edges. If the persistence is k, an edge remains in the drawing for the time spent by the source to generate k edges, and then it fades away. In this model we study the area requirement of planar straight-line grid drawings of trees and we assess the output quality of the presented algorithms by computing the competitive ratio with respect to the best known offline algorithms.
- Published
- 2010
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