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3 results on '"Katharina C. Kiefer"'

1. Full spectrum of clonal haematopoiesis‐driver mutations in chronic heart failure and their associations with mortality

Author

Katharina C. Kiefer, Sebastian Cremer, Evangelia Pardali, Birgit Assmus, Khalil Abou‐El‐Ardat, Klara Kirschbaum, Lena Dorsheimer, Tina Rasper, Alexander Berkowitsch, Hubert Serve, Stefanie Dimmeler, Andreas M. Zeiher, and Michael A. Rieger

Subjects
Blood cell mutations, Clonal haematopoiesis, Heart failure, Age, Diseases of the circulatory (Cardiovascular) system, RC666-701
Abstract

Abstract Aims Somatic mutations in haematopoietic stem cells can lead to the clonal expansion of mutated blood cells, known as clonal haematopoiesis (CH). Mutations in the most prevalent driver genes DNMT3A and TET2 with a variant allele frequency (VAF) ≥ 2% have been associated with atherosclerosis and chronic heart failure of ischemic origin (CHF). However, the effects of mutations in other driver genes for CH with low VAF (

Published
2021
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3. Full spectrum of clonal haematopoiesis-driver mutations in chronic heart failure and their associations with mortality

Author

Katharina C. Kiefer, Sebastian Cremer, Evangelia Pardali, Birgit Assmus, Khalil Abou‐El‐Ardat, Klara Kirschbaum, Lena Dorsheimer, Tina Rasper, Alexander Berkowitsch, Hubert Serve, Stefanie Dimmeler, Andreas M. Zeiher, and Michael A. Rieger

Subjects
Heart Failure, Blood cell mutations, Clonal haematopoiesis, DNA-Binding Proteins, Age, RC666-701, Proto-Oncogene Proteins, Original Research Articles, Mutation, Diseases of the circulatory (Cardiovascular) system, Humans, ddc:610, Original Research Article, Clonal Hematopoiesis
Abstract

Aims Somatic mutations in haematopoietic stem cells can lead to the clonal expansion of mutated blood cells, known as clonal haematopoiesis (CH). Mutations in the most prevalent driver genes DNMT3A and TET2 with a variant allele frequency (VAF) ≥ 2% have been associated with atherosclerosis and chronic heart failure of ischemic origin (CHF). However, the effects of mutations in other driver genes for CH with low VAF (

Published
2020

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