1. Gonadoblastoma in a patient with an isodicentric X chromosome
- Author
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Katayama Kp, Roesler Mr, Richard F. Mattingly, and Dungar Cf
- Subjects
Genetics ,Breast development ,medicine ,Gonadoblastoma ,Chromosome ,Gonadal dysgenesis ,Common denominator ,Biology ,medicine.disease ,Y chromosome ,Genetics (clinical) ,X chromosome - Abstract
Although gonadoblastoma is known to be associated with the presence of a Y chromosome, this case report of a 15-year-old patient with gonadal dysgenesis, gonadoblastoma, and an idic(Xq-) chromosome provides evidence for the occurrence of gonadoblastoma even in the absence of a Y chromosome. A review of previous cases reported to have gonadoblastoma in the absence of a Y chromosome revealed that the presence of some breast development was the common denominator among those patients. Therefore, a patient who presents with gonadal dysgenesis with some breast development, but lacks a Y chromosome may observe as close scrutiny as the patient with gonadal dysgenesis in the presence of a Y chromosome.
- Published
- 1983