203 results on '"Katare R"'
Search Results
2. Myocardial glycophagy flux dysregulation and glycogen accumulation characterize diabetic cardiomyopathy
- Author
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Mellor, KM, Varma, U, Koutsifeli, P, Daniels, LJ, Benson, VL, Annandale, M, Li, X, Nursalim, Y, Janssens, J, Weeks, KL, Powell, KL, O'Brien, TJ, Katare, R, Ritchie, RH, Bell, JR, Gottlieb, RA, Delbridge, LMD, Mellor, KM, Varma, U, Koutsifeli, P, Daniels, LJ, Benson, VL, Annandale, M, Li, X, Nursalim, Y, Janssens, J, Weeks, KL, Powell, KL, O'Brien, TJ, Katare, R, Ritchie, RH, Bell, JR, Gottlieb, RA, and Delbridge, LMD
- Abstract
Diabetic heart disease morbidity and mortality is escalating. No specific therapeutics exist and mechanistic understanding of diabetic cardiomyopathy etiology is lacking. While lipid accumulation is a recognized cardiomyocyte phenotype of diabetes, less is known about glycolytic fuel handling and storage. Based on in vitro studies, we postulated the operation of an autophagy pathway in the myocardium specific for glycogen homeostasis - glycophagy. Here we visualize occurrence of cardiac glycophagy and show that the diabetic myocardium is characterized by marked glycogen elevation and altered cardiomyocyte glycogen localization. We establish that cardiac glycophagy flux is disturbed in diabetes. Glycophagy may represent a potential therapeutic target for alleviating the myocardial impacts of metabolic disruption in diabetic heart disease.
- Published
- 2024
3. Regulation of BACH1 expression by hemin improves cardiac function and revascularisation in a mouse model of myocardial infarction
- Author
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Slater, S, primary, Alvino, V, additional, Avolio, E, additional, Katare, R, additional, and Madeddu, P, additional
- Published
- 2023
- Full Text
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4. Reverse indentation size effects in gamma irradiated blood compatible blend films of chitosan-poly (vinyl alcohol) for possible medical applications
- Author
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Bisen, D.S., Bhatt, Rinkesh, Bajpai, A.K., Bajpai, R., and Katare, R.
- Published
- 2017
- Full Text
- View/download PDF
5. Mechanical and UV absorption behavior of zinc oxide nanoparticles: reinforced poly(vinyl alcohol-g-acrylonitrile) nanocomposite films
- Author
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Chouhan, Shikha, Bajpai, A. K., Bajpai, J., Katare, R., and Dhoble, S. J.
- Published
- 2017
- Full Text
- View/download PDF
6. Investigation of UV absorption and antibacterial behavior of zinc oxide containing poly(vinyl alcohol-g-acrylonitrile) (PVA-g-PAN) nanocomposites films
- Author
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Chouhan, Shikha, Bhatt, Rinkesh, Bajpai, A. K., Bajpai, J., and Katare, R.
- Published
- 2015
- Full Text
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7. Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)
- Author
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Klionsky D, Abdel-Aziz A, Abdelfatah S, Abdellatif M, Abdoli A, Abel S, Abeliovich H, Abildgaard M, Abudu Y, Acevedo-Arozena A, Adamopoulos I, Adeli K, Adolph T, Adornetto A, Aflaki E, Agam G, Agarwal A, Aggarwal B, Agnello M, Agostinis P, Agrewala J, Agrotis A, Aguilar P, Ahmad S, Ahmed Z, Ahumada-Castro U, Aits S, Aizawa S, Akkoc Y, Akoumianaki T, Akpinar H, Al-Abd A, Al-Akra L, Al-Gharaibeh A, Alaoui-Jamali M, Alberti S, Alcocer-Gomez E, Alessandri C, Ali M, Al-Bari M, Aliwaini S, Alizadeh J, Almacellas E, Almasan A, Alonso A, Alonso G, Altan-Bonnet N, Altieri D, Alves S, da Costa C, Alzaharna M, Amadio M, Amantini C, Amaral C, Ambrosio S, Amer A, Ammanathan V, An Z, Andersen S, Andrabi S, Andrade-Silva M, Andres A, Angelini S, Ann D, Anozie U, Ansari M, Antas P, Antebi A, Anton Z, Anwar T, Apetoh L, Apostolova N, Araki T, Araki Y, Arasaki K, Araujo W, Araya J, Arden C, Arevalo M, Arguelles S, Arias E, Arikkath J, Arimoto H, Ariosa A, Armstrong-James D, Arnaune-Pelloquin L, Aroca A, Arroyo D, Arsov I, Artero R, Asaro D, Aschner M, Ashrafizadeh M, Ashur-Fabian O, Atanasov A, Au A, Auberger P, Auner H, Aurelian L, Autelli R, Avagliano L, Avalos Y, Aveic S, Aveleira C, AvinWittenberg T, Aydin Y, Ayton S, Ayyadevara S, Azzopardi M, Baba M, Backer J, Backues S, Bae D, Bae O, Bae S, Baehrecke E, Baek A, Baek S, Bagetta G, Bagniewska-Zadworna A, Bai H, Bai J, Bai X, Bai Y, Bairagi N, Baksi S, Balbi T, Baldari C, Balduini W, Ballabio A, Ballester M, Balazadeh S, Balzan R, Bandopadhyay R, Banerjee S, Bao Y, Baptista M, Baracca A, Barbati C, Bargiela A, Barila D, Barlow P, Barmada S, Barreiro E, Barreto G, Bartek J, Bartel B, Bartolome A, Barve G, Basagoudanavar S, Bassham D, Jr R, Basu A, Batoko H, Batten I, Baulieu E, Baumgarner B, Bayry J, Beale R, Beau I, Beaumatin F, Bechara L, Beck G, Beers M, Begun J, Behrends C, Behrens G, Bei R, Bejarano E, Bel S, Behl C, Belaid A, Belgareh-Touze N, Bellarosa C, Belleudi F, Perez M, Bello-Morales R, Beltran J, Beltran S, Benbrook D, Bendorius M, Benitez B, Benito-Cuesta I, Bensalem J, Berchtold M, Berezowska S, Bergamaschi D, Bergami M, Bergmann A, Berliocchi L, Berlioz-Torrent C, Bernard A, Berthoux L, Besirli C, Besteiro S, Betin V, Beyaert R, Bezbradica J, Bhaskar K, Bhatia-Kissova I, Bhattacharya R, Bhattacharya S, Bhattacharyya S, Bhuiyan M, Bhutia S, Bi L, Bi X, Biden T, Bijian K, Billes V, Binart N, Bincoletto C, Birgisdottir A, Bjorkoy G, Blanco G, Blas-Garcia A, Blasiak J, Blomgran R, Blomgren K, Blum J, Boada-Romero E, Boban M, BoeszeBattaglia K, Boeuf P, Boland B, Bomont P, Bonaldo P, Bonam S, Bonfili L, Bonifacino J, Boone B, Bootman M, Bordi M, Borner C, Bornhauser B, Borthakur G, Bosch J, Bose S, Botana L, Botas J, Boulanger C, Boulton M, Bourdenx M, Bourgeois B, Bourke N, Bousquet G, Boya P, Bozhkov P, Bozi L, Bozkurt T, Brackney D, Brandts C, Braun R, Braus G, Bravo-Sagua R, Bravo-San Pedro J, Brest P, Bringer M, Briones-Herrera A, Broaddus V, Brodersen P, Alvarez E, Brodsky J, Brody S, Bronson P, Bronstein J, Brown C, Brown R, Brum P, Brumell J, Brunetti-Pierri N, Bruno D, Bryson-Richardson R, Bucci C, Buchrieser C, Bueno M, Buitrago-Molina L, Buraschi S, Buch S, Buchan J, Buckingham E, Budak H, Budini M, Bultynck G, Burada F, Burgoyne J, Buron M, Bustos V, Buttner S, Butturini E, Byrd A, Cabas I, Cabrera-Benitez S, Cadwell K, Cai J, Cai L, Cai Q, Cairo M, Calbet J, Caldwell G, Caldwell K, Call J, Calvani R, Calvo A, Barrera M, Camara N, Camonis J, Camougrand N, Campanella M, Campbell E, Campbell-Valois F, Campello S, Campesi I, Campos J, Camuzard O, Cancino J, de Almeida D, Canesi L, Caniggia I, Canonico B, Canti C, Cao B, Caraglia M, Carames B, Carchman E, Cardenal-Munoz E, Cardenas C, Cardenas L, Cardoso S, Carew J, Carle G, Carleton G, Carloni S, Carmona-Gutierrez D, Carneiro L, Carnevali O, Carosi J, Carra S, Carrier A, Carrier L, Carroll B, Carter A, Carvalho A, Casanova M, Casas C, Casas J, Cassioli C, Castillo E, Castillo K, Castillo-Lluva S, Castoldi F, Castori M, Castro A, Castro-Caldas M, Castro-Hernandez J, Castro-Obregon S, Catz S, Cavadas C, Cavaliere F, Cavallini G, Cavinato M, Cayuela M, Rica P, Cecarini V, Cecconi F, Cechowska-Pasko M, Cenci S, Ceperuelo-Mallafre V, Cerqueira J, Cerutti J, Cervia D, Cetintas V, Cetrullo S, Chae H, Chagin A, Chai C, Chakrabarti G, Chakrabarti O, Chakraborty T, Chami M, Chamilos G, Chan D, Chan E, Chan H, Chan M, Chan Y, Chandra P, Chang C, Chang H, Chang K, Chao J, Chapman T, Charlet-Berguerand N, Chatterjee S, Chaube S, Chaudhary A, Chauhan S, Chaum E, Checler F, Cheetham M, Chen C, Chen G, Chen J, Chen L, Chen M, Chen N, Chen Q, Chen R, Chen S, Chen W, Chen X, Chen Y, Chen Z, Cheng H, Cheng J, Cheng S, Cheng W, Cheng X, Cheng Y, Cheng Z, Cheong H, Cheong J, Chernyak B, Cherry S, Cheung C, Cheung K, Chevet E, Chi R, Chiang A, Chiaradonna F, Chiarelli R, Chiariello M, Chica N, Chiocca S, Chiong M, Chiou S, Chiramel A, Chiurchiu V, Cho D, Choe S, Choi A, Choi M, Choudhury K, Chow N, Chu C, Chua J, Chung H, Chung K, Chung S, Chung Y, Cianfanelli V, Ciechomska I, Cifuentes M, Cinque L, Cirak S, Cirone M, Clague M, Clarke R, Clementi E, Coccia E, Codogno P, Cohen E, Cohen M, Colasanti T, Colasuonno F, Colbert R, Colell A, Coll N, Collins M, Colombo M, Colon-Ramos D, Combaret L, Comincini S, Cominetti M, Consiglio A, Conte A, Conti F, Contu V, Cookson M, Coombs K, Coppens I, Corasaniti M, Corkery D, Cordes N, Cortese K, Costa M, Costantino S, Costelli P, Coto-Montes A, Crack P, Crespo J, Criollo A, Crippa V, Cristofani R, Csizmadia T, Cuadrado A, Cui B, Cui J, Cui Y, Culetto E, Cumino A, Cybulsky A, Czaja M, Czuczwar S, D'Adamo S, D'Amelio M, D'Arcangelo D, D'Lugos A, D'Orazi G, da Silva J, Dafsari H, Dagda R, Dagdas Y, Daglia M, Dai X, Dai Y, Dal Col J, Dalhaimer P, Dalla Valle L, Dallenga T, Dalmasso G, Damme M, Dando I, Dantuma N, Darling A, Das H, Dasarathy S, Dasari S, Dash S, Daumke O, Dauphinee A, Davies J, Davila V, Davis R, Davis T, Naidu S, De Amicis F, De Bosscher K, De Felice F, De Franceschi L, De Leonibus C, Barbosa M, De Meyer G, De Milito A, De Nunzio C, De Palma C, De Santi M, De Virgilio C, De Zio D, Debnath J, DeBosch B, Decuypere J, Deehan M, Deflorian G, DeGregori J, Dehay B, Del Rio G, Delaney J, Delbridge L, Delorme-Axford E, Delpino M, Demarchi F, Dembitz V, Demers N, Deng H, Deng Z, Dengjel J, Dent P, Denton D, DePamphilis M, Der C, Deretic V, Descoteaux A, Devis L, Devkota S, Devuyst O, Dewson G, Dharmasivam M, Dhiman R, di Bernardo D, Di Cristina M, Di Domenico F, Di Fazio P, Di Fonzo A, Di Guardo G, Di Guglielmo G, Di Leo L, Di Malta C, Di Nardo A, Di Rienzo M, Di Sano F, Diallinas G, Diao J, Diaz-Araya G, Diaz-Laviada I, Dickinson J, Diederich M, Dieude M, Dikic I, Ding S, Ding W, Dini L, Dinic M, Dinkova-Kostova A, Dionne M, Distler J, Diwan A, Dixon I, Djavaheri-Mergny M, Dobrinski I, Dobrovinskaya O, Dobrowolski R, Dobson R, Emre S, Donadelli M, Dong B, Dong X, Dong Z, Ii G, Dotsch V, Dou H, Dou J, Dowaidar M, Dridi S, Drucker L, Du A, Du C, Du G, Du H, Du L, du Toit A, Duan S, Duan X, Duarte S, Dubrovska A, Dunlop E, Dupont N, Duran R, Dwarakanath B, Dyshlovoy S, Ebrahimi-Fakhari D, Eckhart L, Edelstein C, Efferth T, Eftekharpour E, Eichinger L, Eid N, Eisenberg T, Eissa N, Eissa S, Ejarque M, El Andaloussi A, El-Hage N, El-Naggar S, Eleuteri A, El-Shafey E, Elgendy M, Eliopoulos A, Elizalde M, Elks P, Elsasser H, Elsherbiny E, Emerling B, Emre N, Eng C, Engedal N, Engelbrecht A, Engelsen A, Enserink J, Escalante R, Esclatine A, Escobar-Henriques M, Eskelinen E, Espert L, Eusebio M, Fabrias G, Fabrizi C, Facchiano A, Facchiano F, Fadeel B, Fader C, Faesen A, Fairlie W, Falco A, Falkenburger B, Fan D, Fan J, Fan Y, Fang E, Fang Y, Fanto M, Farfel-Becker T, Faure M, Fazeli G, Fedele A, Feldman A, Feng D, Feng J, Feng L, Feng Y, Feng W, Araujo T, Ferguson T, Fernandez-Checa J, FernandezVeledo S, Fernie A, Ferrante A, Ferraresi A, Ferrari M, Ferreira J, Ferro-Novick S, Figueras A, Filadi R, Filigheddu N, FilippiChiela E, Filomeni G, Fimia G, Fineschi V, Finetti F, Finkbeiner S, Fisher E, Fisher P, Flamigni F, Fliesler S, Flo T, Florance I, Florey O, Florio T, Fodor E, Follo C, Fon E, Forlino A, Fornai F, Fortini P, Fracassi A, Fraldi A, Franco B, Franco R, Franconi F, Frankel L, Friedman S, Frohlich L, Fruhbeck G, Fuentes J, Fujiki Y, Fujita N, Fujiwara Y, Fukuda M, Fulda S, Furic L, Furuya N, Fusco C, Gack M, Gaffke L, Galadari S, Galasso A, Galindo M, Kankanamalage S, Galluzzi L, Galy V, Gammoh N, Gan B, Ganley I, Gao F, Gao H, Gao M, Gao P, Gao S, Gao W, Gao X, Garcera A, Garcia M, Garcia V, Garcia-Del Portillo F, Garcia-Escudero V, GarciaGarcia A, Garcia-Macia M, Garcia-Moreno D, Garcia-Ruiz C, Garcia-Sanz P, Garg A, Gargini R, Garofalo T, Garry R, Gassen N, Gatica D, Ge L, Ge W, Geiss-Friedlander R, Gelfi C, Genschik P, Gentle I, Gerbino V, Gerhardt C, Germain K, Germain M, Gewirtz D, Afshar E, Ghavami S, Ghigo A, Ghosh M, Giamas G, Giampietri C, Giatromanolaki A, Gibson G, Gibson S, Ginet V, Giniger E, Giorgi C, Girao H, Girardin S, Giridharan M, Giuliano S, Giulivi C, Giuriato S, Giustiniani J, Gluschko A, Goder V, Goginashvili A, Golab J, Goldstone D, Golebiewska A, Gomes L, Gomez R, Gomez-Sanchez R, Gomez-Puerto M, Gomez-Sintes R, Gong Q, Goni F, Gonzalez-Gallego J, Gonzalez-Hernandez T, Gonzalez-Polo R, Gonzalez-Reyes J, Gonzalez-Rodriguez P, Goping I, Gorbatyuk M, Gorbunov N, Gorojod R, Gorski S, Goruppi S, Gotor C, Gottlieb R, Gozes I, Gozuacik D, Graef M, Graler M, Granatiero V, Grasso D, Gray J, Green D, Greenhough A, Gregory S, Griffin E, Grinstaff M, Gros F, Grose C, Gross A, Gruber F, Grumati P, Grune T, Gu X, Guan J, Guardia C, Guda K, Guerra F, Guerri C, Guha P, Guillen C, Gujar S, Gukovskaya A, Gukovsky I, Gunst J, Gunther A, Guntur A, Guo C, Guo H, Guo L, Guo M, Gupta P, Fernandez A, Gupta S, Gupta V, Gustafsson A, Gutterman D, Ranjitha H, Haapasalo A, Haber J, Hadano S, Hafren A, Haidar M, Hall B, Hallden G, Hamacher-Brady A, Hamann A, Hamasaki M, Han W, Hansen M, Hanson P, Hao Z, Harada M, Harhaji-Trajkovic L, Hariharan N, Haroon N, Harris J, Hasegawa T, Nagoor N, Haspel J, Haucke V, Hawkins W, Hay B, Haynes C, Hayrabedyan S, Hays T, He C, He Q, He R, He Y, Heakal Y, Heberle A, Hejtmancik J, Helgason G, Henkel V, Herb M, Hergovich A, Herman-Antosiewicz A, Hernandez A, Hernandez C, Hernandez-Diaz S, Hernandez-Gea V, Herpin A, Herreros J, Hervas J, Hesselson D, Hetz C, Heussler V, Higuchi Y, Hilfiker S, Hill J, Hlavacek W, Ho E, Ho I, Ho P, Ho S, Ho W, Hobbs G, Hochstrasser M, Hoet P, Hofius D, Hofman P, Hohn A, Holmberg C, Hombrebueno J, Hong C, Hong Y, Hooper L, Hoppe T, Horos R, Hoshida Y, Hsin I, Hsu H, Hu B, Hu D, Hu L, Hu M, Hu R, Hu W, Hu Y, Hu Z, Hua F, Hua J, Hua Y, Huan C, Huang C, Huang H, Huang K, Huang M, Huang R, Huang S, Huang T, Huang X, Huang Y, Huber T, Hubert V, Hubner C, Hughes S, Hughes W, Humbert M, Hummer G, Hurley J, Hussain S, Hussey P, Hutabarat M, Hwang H, Hwang S, Ieni A, Ikeda F, Imagawa Y, Imai Y, Imbriano C, Imoto M, Inman D, Inoki K, Iovanna J, Iozzo R, Ippolito G, Irazoqui J, Iribarren P, Ishaq M, Ishikawa M, Ishimwe N, Isidoro C, Ismail N, Issazadeh-Navikas S, Itakura E, Ito D, Ivankovic D, Ivanova S, Iyer A, Izquierdo J, Izumi M, Jaattela M, Jabir M, Jackson W, Jacobo-Herrera N, Jacomin A, Jacquin E, Jadiya P, Jaeschke H, Jagannath C, Jakobi A, Jakobsson J, Janji B, JansenDurr P, Jansson P, Jantsch J, Jassey A, Jean S, JeltschDavid H, Jendelova P, Jenny A, Jensen T, Jessen N, Jewell J, Ji J, Jia L, Jia R, Jiang L, Jiang Q, Jiang R, Jiang T, Jiang X, Jiang Y, Jimenez-Sanchez M, Jin E, Jin F, Jin H, Jin L, Jin M, Jin S, Jo E, Joffre C, Johansen T, Johnson G, Johnston S, Jokitalo E, Jolly M, Joosten L, Jordan J, Joseph B, Ju D, Ju J, Juarez E, Judith D, Juhasz G, Jun Y, Jung C, Jung S, Jung Y, Jungbluth H, Jungverdorben J, Just S, Kaarniranta K, Kaasik A, Kabuta T, Kaganovich D, Kahana A, Kain R, Kajimura S, Kalamvoki M, Kalia M, Kalinowski D, Kaludercic N, Kalvari I, Kaminska J, Kaminskyy V, Kanamori H, Kanasaki K, Kang C, Kang R, Kang S, Kaniyappan S, Kanki T, Kanneganti T, Kanthasamy A, Kantorow M, Kapuy O, Karamouzis M, Karim M, Karmakar P, Katare R, Kato M, Kaufmann S, Kauppinen A, Kaushal G, Kaushik S, Kawasaki K, Kazan K, Ke P, Keating D, Keber U, Kehrl J, Keller K, Keller C, Kemper J, Kenific C, Kepp O, Kermorgant S, Kern A, Ketteler R, Keulers T, Khalfin B, Khalil H, Khambu B, Khan S, Khandelwal V, Khandia R, Kho W, Khobrekar N, Khuansuwan S, Khundadze M, Killackey S, Kim D, Kim E, Kim H, Kim J, Kim K, Kim P, Kim S, Kimball S, Kimchi A, Kimmelman A, Kimura T, King M, Kinghorn K, Kinsey C, Kirkin V, Kirshenbaum L, Kiselev S, Kishi S, Kitamoto K, Kitaoka Y, Kitazato K, Kitsis R, Kittler J, Kjaerulff O, Klein P, Klopstock T, Klucken J, Knovelsrud H, Knorr R, Ko B, Ko F, Ko J, Kobayashi H, Kobayashi S, Koch I, Koch J, Koenig U, Kogel D, Koh Y, Koike M, Kohlwein S, Kocaturk N, Komatsu M, Konig J, Kono T, Kopp B, Korcsmaros T, Korkmaz G, Korolchuk V, Korsnes M, Koskela A, Kota J, Kotake Y, Kotler M, Kou Y, Koukourakis M, Koustas E, Kovacs A, Kovacs T, Koya D, Kozako T, Kraft C, Krainc D, Kramer H, Krasnodembskaya A, Kretz-Remy C, Kroemer G, Ktistakis N, Kuchitsu K, Kuenen S, Kuerschner L, Kukar T, Kumar A, Kumar D, Kumar S, Kume S, Kumsta C, Kundu C, Kundu M, Kunnumakkara A, Kurgan L, Kutateladze T, Kutlu O, Kwak S, Kwon H, Kwon T, Kwon Y, Kyrmizi I, La Spada A, Labonte P, Ladoire S, Laface I, Lafont F, Lagace D, Lahiri V, Lai Z, Laird A, Lakkaraju A, Lamark T, Lan S, Landajuela A, Lane D, Lane J, Lang C, Lange C, Langer R, Lapaquette P, Laporte J, LaRusso N, Lastres-Becker I, Lau W, Laurie G, Lavandero S, Law B, Law H, Layfield R, Le W, Le Stunff H, Leary A, Lebrun J, Leck L, Leduc-Gaudet J, Lee C, Lee D, Lee E, Lee G, Lee H, Lee J, Lee M, Lee S, Lee W, Lee Y, Lefebvre C, Legouis R, Lei Y, Leikin S, Leitinger G, Lemus L, Leng S, Lenoir O, Lenz G, Lenz H, Lenzi P, Leon Y, Leopoldino A, Leschczyk C, Leskela S, Letellier E, Leung C, Leung P, Leventhal J, Levine B, Lewis P, Ley K, Li B, Li D, Li J, Li K, Li L, Li M, Li P, Li Q, Li S, Li T, Li W, Li X, Li Y, Li Z, Lian J, Liang C, Liang Q, Liang W, Liang Y, Liao G, Liao L, Liao M, Liao Y, Librizzi M, Lie P, Lilly M, Lim H, Lima T, Limana F, Lin C, Lin D, Lin F, Lin J, Lin K, Lin L, Lin P, Lin Q, Lin S, Lin W, Lin X, Lin Y, Linden R, Lindner P, Ling S, Lingor P, Linnemann A, Liou Y, Lipinski M, Lipovsek S, Lira V, Lisiak N, Liton P, Liu C, Liu F, Liu H, Liu J, Liu L, Liu M, Liu Q, Liu W, Liu X, Liu Y, Livingston J, Lizard G, Lizcano J, Ljubojevic-Holzer S, LLeonart M, Llobet-Navas D, Llorente A, Lo C, Lobato-Marquez D, Long Q, Long Y, Loos B, Loos J, Lopez M, Lopez-Domenech G, Lopez-Guerrero J, Lopez-Jimenez A, Lopez-Valero I, Lorenowicz M, Lorente M, Lorincz P, Lossi L, Lotersztajn S, Lovat P, Lovell J, Lovy A, Lu G, Lu H, Lu J, Lu M, Lu S, Luciani A, Lucocq J, Ludovico P, Luftig M, Luhr M, Luis-Ravelo D, Lum J, Luna-Dulcey L, Lund A, Lund V, Lunemann J, Luningschror P, Luo 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flux ,macroautophagy ,phagophore ,stress ,vacuole ,Autophagosome ,LC3 ,lysosome ,neurodegeneration ,cancer - Abstract
In 2008, we published the first set of guidelines for standardizing research in autophagy. Since then, this topic has received increasing attention, and many scientists have entered the field. Our knowledge base and relevant new technologies have also been expanding. Thus, it is important to formulate on a regular basis updated guidelines for monitoring autophagy in different organisms. Despite numerous reviews, there continues to be confusion regarding acceptable methods to evaluate autophagy, especially in multicellular eukaryotes. Here, we present a set of guidelines for investigators to select and interpret methods to examine autophagy and related processes, and for reviewers to provide realistic and reasonable critiques of reports that are focused on these processes. These guidelines are not meant to be a dogmatic set of rules, because the appropriateness of any assay largely depends on the question being asked and the system being used. Moreover, no individual assay is perfect for every situation, calling for the use of multiple techniques to properly monitor autophagy in each experimental setting. Finally, several core components of the autophagy machinery have been implicated in distinct autophagic processes (canonical and noncanonical autophagy), implying that genetic approaches to block autophagy should rely on targeting two or more autophagy-related genes that ideally participate in distinct steps of the pathway. Along similar lines, because multiple proteins involved in autophagy also regulate other cellular pathways including apoptosis, not all of them can be used as a specific marker for bona fide autophagic responses. Here, we critically discuss current methods of assessing autophagy and the information they can, or cannot, provide. Our ultimate goal is to encourage intellectual and technical innovation in the field.
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- 2021
8. Elevated myocardial fructose and sorbitol levels are associated with diastolic dysfunction in diabetic patients, and cardiomyocyte lipid inclusions in vitro
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Daniels, LJ, Annandale, M, Koutsifeli, P, Li, X, Bussey, CT, van Hout, I, Bunton, RW, Davis, PJ, Coffey, S, Katare, R, Lamberts, RR, Delbridge, LMD, Mellor, KM, Daniels, LJ, Annandale, M, Koutsifeli, P, Li, X, Bussey, CT, van Hout, I, Bunton, RW, Davis, PJ, Coffey, S, Katare, R, Lamberts, RR, Delbridge, LMD, and Mellor, KM
- Abstract
Diabetes is associated with cardiac metabolic disturbances and increased heart failure risk. Plasma fructose levels are elevated in diabetic patients. A direct role for fructose involvement in diabetic heart pathology has not been investigated. The goals of this study were to clinically evaluate links between myocardial fructose and sorbitol (a polyol pathway fructose precursor) levels with evidence of cardiac dysfunction, and to experimentally assess the cardiomyocyte mechanisms involved in mediating the metabolic effects of elevated fructose. Fructose and sorbitol levels were increased in right atrial appendage tissues of type 2 diabetic patients (2.8- and 1.5-fold increase respectively). Elevated cardiac fructose levels were confirmed in type 2 diabetic rats. Diastolic dysfunction (increased E/e', echocardiography) was significantly correlated with cardiac sorbitol levels. Elevated myocardial mRNA expression of the fructose-specific transporter, Glut5 (43% increase), and the key fructose-metabolizing enzyme, Fructokinase-A (50% increase) was observed in type 2 diabetic rats (Zucker diabetic fatty rat). In neonatal rat ventricular myocytes, fructose increased glycolytic capacity and cytosolic lipid inclusions (28% increase in lipid droplets/cell). This study provides the first evidence that elevated myocardial fructose and sorbitol are associated with diastolic dysfunction in diabetic patients. Experimental evidence suggests that fructose promotes the formation of cardiomyocyte cytosolic lipid inclusions, and may contribute to lipotoxicity in the diabetic heart.
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- 2021
9. Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)
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Werner, Brand-Saberi, Beate, Dong, X Charlie, Kenchappa, Chandra Shekar, Li, Zuguo, Lin, Yong, Oshima, Shigeru, Rong, Yueguang, Sluimer, Judith C, Stallings, Christina L, and Tong, Chun-Kit
- Abstract
In 2008, we published the first set of guidelines for standardizing research in autophagy. Since then, this topic has received increasing attention, and many scientists have entered the field. Our knowledge base and relevant new technologies have also been expanding. Thus, it is important to formulate on a regular basis updated guidelines for monitoring autophagy in different organisms. Despite numerous reviews, there continues to be confusion regarding acceptable methods to evaluate autophagy, especially in multicellular eukaryotes. Here, we present a set of guidelines for investigators to select and interpret methods to examine autophagy and related processes, and for reviewers to provide realistic and reasonable critiques of reports that are focused on these processes. These guidelines are not meant to be a dogmatic set of rules, because the appropriateness of any assay largely depends on the question being asked and the system being used. Moreover, no individual assay is perfect for every situation, calling for the use of multiple techniques to properly monitor autophagy in each experimental setting. Finally, several core components of the autophagy machinery have been implicated in distinct autophagic processes (canonical and noncanonical autophagy), implying that genetic approaches to block autophagy should rely on targeting two or more autophagy-related genes that ideally participate in distinct steps of the pathway. Along similar lines, because multiple proteins involved in autophagy also regulate other cellular pathways including apoptosis, not all of them can be used as a specific marker for bona fide autophagic responses. Here, we critically discuss current methods of assessing autophagy and the information they can, or cannot, provide. Our ultimate goal is to encourage intellectual and technical innovation in the field.
- Published
- 2021
10. P593Human vascular pericytes and cardiac progenitor cells combined transplantation for heart repair
- Author
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Avolio, E, Mangialardi, G, Riu, F, Katare, R, Mitchell, K, Dang, Z, Spencer, H, Meloni, M, Beltrami, AP, and Madeddu, P
- Published
- 2014
- Full Text
- View/download PDF
11. 289Pharmacologic rejuvenation of senescent human cardiac stem cells enhances myocardial repair
- Author
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Avolio, E, Gianfranceschi, G, Caragnano, A, Athanasakis, E, Katare, R, Meloni, M, Beltrami, CA, Cesselli, D, Madeddu, P, and Beltrami, AP
- Published
- 2014
- Full Text
- View/download PDF
12. On the mechanical strength of biocompatible semi-IPNs of polyvinyl alcohol and polyacrylamide
- Author
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Mishra, Shefali, Bajpai, R., Katare, R., and Bajpai, A. K.
- Published
- 2008
- Full Text
- View/download PDF
13. Preparation, characterization and microhardness study of semi interpenetrating polymer networks of polyvinyl alcohol and crosslinked polyacrylamide
- Author
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Mishra, Shefali, Bajpai, R., Katare, R., and Bajpai, A. K.
- Published
- 2006
- Full Text
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14. Elevation of Cardiac Fructose Precedes the Onset of Diastolic Dysfunction in Diabetes
- Author
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Annandale, M., primary, Daniels, L., additional, Li, X., additional, Macindoe, C., additional, Coffey, S., additional, Katare, R., additional, Delbridge, L., additional, and Mellor, K., additional
- Published
- 2021
- Full Text
- View/download PDF
15. Development of hardened PVF : PMMA polyblend: effect of gamma and electron irradiation
- Author
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Bajpai, R, Dhagat, N B, Katare, R, Agrawal, Pragyesh, and Datt, S C
- Published
- 2003
- Full Text
- View/download PDF
16. P593Nociceptive Signaling Contributes to Progenitor Cells Activation and Mobilization During Ischemia in Mice and Human Subjects
- Author
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Amadesi, S., Fortunato, O., Reni, C., Katare, R., Meloni, M., Ascione, R., Spinetti, G., Cangiano, E., Valgimigli, M., and Madeddu, P.
- Published
- 2012
17. P588Diabetes alters bone marrow vascular niche by Akt impairment and increased vascular permeability throughout Src activation
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Mangialardi, G., Katare, R., Oikawa, A., and Madeddu, P.
- Published
- 2012
18. P507Importance of mouse hematopoietic stem cells in neovascularisation
- Author
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Oikawa, A., Katare, R., Herman, A., Emanueli, C., and Madeddu, P.
- Published
- 2012
19. P490Diabetes induces maladaptive autophagy in cardiomyocytes and resident cardiac stem cells
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Katare, R., Oikawa, A., Riu, F., Beltrami, A.P., Cesseli, D., Emanueli, C., and Madeddu, P.
- Published
- 2012
20. Bilirubin Oxidation Provoked by Nitric Oxide Radicals Predicts the Progression of Acute Cardiac Allograft Rejection
- Author
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Yamamoto, M., Maeda, H., Hirose, N., Radhakrishnan, G., Katare, R. G., Hayashi, Y., Rao, P., Lee, G.-H., Yamaguchi, T., and Sasaguri, S.
- Published
- 2007
21. P6309Impaired secretion of clusterin in pericardial fluid of diabetics, a deleterious outcome for the cardiac micro-vasculature
- Author
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Dixit, P, primary, Anwar, M, additional, Saif, J, additional, Chamorro-Jorganes, A, additional, Dumas, M, additional, Angelini, G, additional, Punjabi, P, additional, Srivastava, P, additional, Katare, R, additional, Petretto, E, additional, and Emanueli, C, additional
- Published
- 2019
- Full Text
- View/download PDF
22. P712Non-neuronal cholinergic system prevents coronary vascular dysfunction in diabetic heart
- Author
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Saw, E, primary, Tsuchimochi, H, additional, Pearson, J T, additional, Yoshihiko, K, additional, Schwenke, D O, additional, Fronius, M, additional, and Katare, R, additional
- Published
- 2019
- Full Text
- View/download PDF
23. P1936Selective inhibition of the Mek1/2-Erk1/2 signalling pathway induces the differentiation of human cardiac pericyte-like cells into contractile vascular smooth muscle cells
- Author
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Avolio, E, primary, Thomas, A, additional, Katare, R, additional, Al Haj Zen, A, additional, Beltrami, A P, additional, Leor, J, additional, Caputo, M, additional, and Madeddu, P, additional
- Published
- 2019
- Full Text
- View/download PDF
24. WITHDRAWN: GLP-1 Has an Anti-Inflammatory Effect on Adipose Tissue Expression of Cytokines, Chemokines, and Receptors in Obese Women
- Author
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Manning, P J, primary, Dixit, P, additional, Satthenapalli, V R, additional, Katare, R, additional, and Sutherland, W H F, additional
- Published
- 2019
- Full Text
- View/download PDF
25. P6565Ghrelin deletion impairs postischaemic revascularisation in a murine model of critical limb ischaemia
- Author
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Neale, J, primary, Pearson, J, additional, Tsuchimochi, H, additional, Sonobe, T, additional, Daniels, L, additional, Katare, R, additional, and Schwenke, D, additional
- Published
- 2018
- Full Text
- View/download PDF
26. 233High-intensity interval exercise attenuates cardiac remodelling in type-2 diabetes possibly through microRNAs restoration
- Author
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Lew, JKS, primary, Pearson, J T, additional, Katare, R, additional, and Schwenke, D O, additional
- Published
- 2018
- Full Text
- View/download PDF
27. 438Cardioprotection of moderate-intensity exercise is prognosis-dependent in type-2 diabetic mouse
- Author
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Lew, JKS, primary, Pearson, J T, additional, Katare, R, additional, and Schwenke, D O, additional
- Published
- 2018
- Full Text
- View/download PDF
28. Non-Neuronal Cholinergic System in the Diabetic Heart
- Author
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Saw, E., primary, Rawal, S., additional, Bunton, R., additional, Galvin, I., additional, Davis, P., additional, Fronius, M., additional, and Katare, R., additional
- Published
- 2018
- Full Text
- View/download PDF
29. Ghrelin Deletion Impairs Postischaemic Revascularisation in a Murine Model of Critical Limb Ischaemia
- Author
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Neale, J., primary, Pearson, J., additional, Tsuchimochi, H., additional, Sonobe, T., additional, Daniels, L., additional, Katare, R., additional, and Schwenke, D., additional
- Published
- 2018
- Full Text
- View/download PDF
30. P4452High-intensity interval exercise attenuates cardiac dysfunction and improves cardiac perfusion through restoration of microRNA-126 in type-2 diabetic mice
- Author
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Lew, K.S., primary, Pearson, J.T., additional, Katare, R., additional, and Schwenke, D.O., additional
- Published
- 2017
- Full Text
- View/download PDF
31. Human pericyte progenitor cells and cardiac progenitor cells for specialized stimulation of neovascularization and cardiomyogenesis of the infarcted heart
- Author
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Mitchell, Kj, Katare, R, Riu, F, Gubernator, M, Beltrami, Antonio Paolo, and Madeddu, P.
- Published
- 2012
32. Diabetes induces maladaptive autophagy in cardiomyocytes and resident cardiac stem cells
- Author
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Katare, R, Oikawa, A, Riu, F, Beltrami, Antonio Paolo, Cesseli, D, Emanueli, C, and Madeddu, P.
- Published
- 2012
33. Orchestrated role of cardiovascular microRNAs in diabetic cardiomyopathy
- Author
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Rawal, S., primary, Munasinghe, E., additional, Shindikar, A., additional, Manning, P., additional, and Katare, R., additional
- Published
- 2015
- Full Text
- View/download PDF
34. Diabetes causes the activation of the pro-ageing miRNA-34a in the human heart
- Author
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Fomison-Nurse, I., primary, Saxena, P., additional, Coffey, S., additional, Menon, A., additional, Bunton, R., additional, Galvin, I., additional, Bahn, A., additional, Williams, M., additional, Cameron, V., additional, and Katare, R., additional
- Published
- 2014
- Full Text
- View/download PDF
35. Circulating cardiovascular microRNAs as diagnostic biomarkers for early diagnosis of diabetic heart disease
- Author
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Rawal, S., primary, Paulin, J., additional, Munasinghe, E., additional, Manning, P., additional, and Katare, R., additional
- Published
- 2014
- Full Text
- View/download PDF
36. Pathological autophagy augments cell death in the diabetic heart
- Author
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Munasinghe, E., primary, Fomison-Nurse, I., additional, Hughes, G., additional, Saxena, P., additional, Bunton, R., additional, Galvin, I., additional, and Katare, R., additional
- Published
- 2014
- Full Text
- View/download PDF
37. Poster session 3
- Author
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Nanka, O., primary, Krejci, E., additional, Pesevski, Z., additional, Sedmera, D., additional, Smart, N., additional, Rossdeutsch, A., additional, Dube, K. N., additional, Riegler, J., additional, Price, A. N., additional, Taylor, A., additional, Muthurangu, V., additional, Turner, M., additional, Lythgoe, M. F., additional, Riley, P. R., additional, Kryvorot, S., additional, Vladimirskaya, T., additional, Shved, I., additional, Schwarzl, M., additional, Seiler, S., additional, Huber, S., additional, Steendijk, P., additional, Maechler, H., additional, Truschnig-Wilders, M., additional, Pieske, B., additional, Post, H., additional, Caprio, C., additional, Baldini, A., additional, Chiavacci, E., additional, Dolfi, L., additional, Verduci, L., additional, Meghini, F., additional, Cremisi, F., additional, Pitto, L., additional, Kuan, T.-C., additional, Chen, M.-C., additional, Yang, T.-H., additional, Wu, W.-T., additional, Lin, C. S., additional, Rai, H., additional, Kumar, S., additional, Sharma, A. K., additional, Mastana, S., additional, Kapoor, A., additional, Pandey, C. M., additional, Agrawal, S., additional, Sinha, N., additional, Orlowska-Baranowska, E. H., additional, Placha, G., additional, Gora, J., additional, Baranowski, R., additional, Abramczuk, E., additional, Hryniewiecki, T., additional, Gaciong, Z., additional, Verschuren, J. J. W., additional, Wessels, J. A. M., additional, Trompet, S., additional, Stott, D. J., additional, Sattar, N., additional, Buckley, B., additional, Guchelaar, H. J., additional, Jukema, J. W., additional, Gharanei, M., additional, Hussain, A., additional, Mee, C. J., additional, Maddock, H. L., additional, Wijnen, W. J., additional, Van Den Oever, S., additional, Van Der Made, I., additional, Hiller, M., additional, Tijsen, A. J., additional, Pinto, Y. M., additional, Creemers, E. E., additional, Nikulina, S. U. Y., additional, Chernova, A., additional, Petry, A., additional, Rzymski, T., additional, Kracun, D., additional, Riess, F., additional, Pike, L., additional, Harris, A. L., additional, Gorlach, A., additional, Katare, R., additional, Oikawa, A., additional, Riu, F., additional, Beltrami, A. P., additional, Cesseli, D., additional, Emanueli, C., additional, Madeddu, P., additional, Zaglia, T., additional, Milan, G., additional, Franzoso, M., additional, Pesce, P., additional, Sarais, C., additional, Sandri, M., additional, Mongillo, M., additional, Butler, T. J., additional, Seymour, A.-M. L., additional, Ashford, D., additional, Jaffre, F., additional, Bussen, M., additional, Flohrschutz, I., additional, Martin, G. R., additional, Engelhardt, S., additional, Kararigas, G., additional, Nguyen, B. T., additional, Jarry, H., additional, Regitz-Zagrosek, V., additional, Van Bilsen, M., additional, Daniels, A., additional, Munts, C., additional, Janssen, B. J. A., additional, Van Der Vusse, G. J., additional, Van Nieuwenhoven, F. A., additional, Montalvo, C., additional, Villar, A. V., additional, Merino, D., additional, Garcia, R., additional, Llano, M., additional, Ares, M., additional, Hurle, M. A., additional, Nistal, J. F., additional, Dembinska-Kiec, A., additional, Beata Kiec-Wilk, B. K. W., additional, Anna Polus, A. P., additional, Urszula Czech, U. C., additional, Tatiana Konovaleva, T. K., additional, Gerd Schmitz, G. S., additional, Bertrand, L., additional, Balteau, M., additional, Timmermans, A., additional, Viollet, B., additional, Sakamoto, K., additional, Feron, O., additional, Horman, S., additional, Vanoverschelde, J. L., additional, Beauloye, C., additional, De Meester, C., additional, Martinez, E., additional, Martin, R., additional, Miana, M., additional, Jurado, R., additional, Gomez-Hurtado, N., additional, Bartolome, M. V., additional, San Roman, J. A., additional, Lahera, V., additional, Nieto, M. L., additional, Cachofeiro, V., additional, Rochais, F., additional, Sturny, R., additional, Mesbah, K., additional, Miquerol, L., additional, Kelly, R. G., additional, Messaoudi, S., additional, Gravez, B., additional, Tarjus, A., additional, Pelloux, V., additional, Samuel, J. L., additional, Delcayre, C., additional, Launay, J. M., additional, Clement, K., additional, Farman, N., additional, Jaisser, F., additional, Hadyanto, L., additional, Castellani, C., additional, Vescovo, G., additional, Ravara, B., additional, Tavano, R., additional, Pozzobon, M., additional, De Coppi, P., additional, Papini, E., additional, Vettor, R., additional, Thiene, G., additional, Angelini, A., additional, Meloni, M., additional, Caporali, A., additional, Cesselli, D., additional, Fortunato, O., additional, Avolio, E., additional, Schindler, R., additional, Simrick, S., additional, Brand, T., additional, Smart, N. S., additional, Herman, A., additional, Roura Ferrer, S., additional, Rodriguez Bago, J., additional, Soler-Botija, C., additional, Pujal, J. M., additional, Galvez-Monton, C., additional, Prat-Vidal, C., additional, Llucia-Valldeperas, A., additional, Blanco, J., additional, Bayes-Genis, A., additional, Foldes, G., additional, Maxime, M., additional, Ali, N. N., additional, Schneider, M. D., additional, Harding, S. E., additional, Reni, C., additional, Mangialardi, G., additional, De Pauw, A., additional, Sekkali, B., additional, Friart, A., additional, Ding, H., additional, Graffeuil, A., additional, Catalucci, D., additional, Balligand, J. L., additional, Azibani, F., additional, Tournoux, F., additional, Schlossarek, S., additional, Polidano, E., additional, Fazal, L., additional, Merval, R., additional, Carrier, L., additional, Chatziantoniou, C., additional, Buyandelger, B., additional, Linke, W., additional, Zou, P., additional, Kostin, S., additional, Ku, C., additional, Felkin, L., additional, Birks, E., additional, Barton, P., additional, Sattler, M., additional, Knoell, R., additional, Schroder, K., additional, Benkhoff, S., additional, Shimokawa, H., additional, Grisk, O., additional, Brandes, R. P., additional, Parepa, I. R., additional, Mazilu, L., additional, Suceveanu, A. I., additional, Suceveanu, A., additional, Rusali, L., additional, Cojocaru, L., additional, Matei, L., additional, Toringhibel, M., additional, Craiu, E., additional, Pires, A. L., additional, Pinho, M., additional, Pinho, S., additional, Sena, C., additional, Seica, R., additional, Leite-Moreira, A., additional, Dabroi, F., additional, Schiaffino, S., additional, Kiseleva, E., additional, Krukov, N., additional, Nikitin, O., additional, Ardatova, L., additional, Mourouzis, I., additional, Pantos, C., additional, Kokkinos, A. D., additional, Cokkinos, D. V., additional, Scoditti, E., additional, Massaro, M., additional, Carluccio, M. A., additional, Pellegrino, M., additional, Calabriso, N., additional, Gastaldelli, A., additional, Storelli, C., additional, De Caterina, R., additional, Lindner, D., additional, Zietsch, C., additional, Schultheiss, H.-P., additional, Tschope, C., additional, Westermann, D., additional, Everaert, B. R., additional, Nijenhuis, V. J., additional, Reith, F. C. M., additional, Hoymans, V. Y., additional, Timmermans, J. P., additional, Vrints, C. J., additional, Simova, I., additional, Mateev, H., additional, Katova, T., additional, Haralanov, L., additional, Dimitrov, N., additional, Mironov, N., additional, Golitsyn, S. P., additional, Sokolov, S. F., additional, Yuricheva, Y. U. A., additional, Maikov, E. B., additional, Shlevkov, N. B., additional, Rosenstraukh, L. V., additional, Chazov, E. I., additional, Radosinska, J., additional, Knezl, V., additional, Benova, T., additional, Slezak, J., additional, Urban, L., additional, Tribulova, N., additional, Virag, L., additional, Kristof, A., additional, Kohajda, Z. S., additional, Szel, T., additional, Husti, Z., additional, Baczko, I., additional, Jost, N., additional, Varro, A., additional, Sarusi, A., additional, Farkas, A. S., additional, Orosz, S. Z., additional, Forster, T., additional, Farkas, A., additional, Zakhrabova-Zwiauer, O. M., additional, Hardziyenka, M., additional, Nieuwland, R., additional, Tan, H. L., additional, Raaijmakers, A. J. A., additional, Bourgonje, V. J. A., additional, Kok, G. J. M., additional, Van Veen, A. A. B., additional, Anderson, M. E., additional, Vos, M. A., additional, Bierhuizen, M. F. A., additional, Benes, J., additional, Sebestova, B., additional, Ghouri, I. A., additional, Kemi, O. J., additional, Kelly, A., additional, Burton, F. L., additional, Smith, G. L., additional, Ozdemir, S., additional, Acsai, K., additional, Doisne, N., additional, Van Der Nagel, R., additional, Beekman, H. D. M., additional, Van Veen, T. A. B., additional, Sipido, K. R., additional, Antoons, G., additional, Harmer, S. C., additional, Mohal, J. S., additional, Kemp, D., additional, Tinker, A., additional, Beech, D., additional, Burley, D. S., additional, Cox, C. D., additional, Wann, K. T., additional, Baxter, G. F., additional, Wilders, R., additional, Verkerk, A., additional, Fragkiadaki, P., additional, Germanakis, G., additional, Tsarouchas, K., additional, Tsitsimpikou, C., additional, Tsardi, M., additional, George, D., additional, Tsatsakis, A., additional, Rodrigues, P., additional, Barros, C., additional, Najmi, A. K., additional, Khan, V., additional, Akhtar, M., additional, Pillai, K. K., additional, Mujeeb, M., additional, Aqil, M., additional, Bayliss, C. R., additional, Messer, A. E., additional, Leung, M.-C., additional, Ward, D., additional, Van Der Velden, J., additional, Poggesi, C., additional, Redwood, C. S., additional, Marston, S., additional, Vite, A., additional, Gandjbakhch, E., additional, Gary, F., additional, Fressart, V., additional, Leprince, P., additional, Fontaine, G., additional, Komajda, M., additional, Charron, P., additional, Villard, E., additional, Falcao-Pires, I., additional, Gavina, C., additional, Hamdani, N., additional, Stienen, G. J. M., additional, Niessens, H. W. M., additional, Leite-Moreira, A. F., additional, Paulus, W. J., additional, Memo, M., additional, Marston, S. B., additional, Vafiadaki, E., additional, Qian, J., additional, Arvanitis, D. A., additional, Sanoudou, D., additional, Kranias, E. G., additional, Elmstedt, N., additional, Lind, B., additional, Ferm-Widlund, K., additional, Westgren, M., additional, Brodin, L.-A., additional, Mansfield, C., additional, West, T., additional, Ferenczi, M., additional, Wijnker, P. J. M., additional, Foster, D. B., additional, Coulter, A., additional, Frazier, A., additional, Murphy, A. M., additional, Shah, M., additional, Sikkel, M. B., additional, Desplantez, T., additional, Collins, T. P., additional, O' Gara, P., additional, Lyon, A. R., additional, Macleod, K. T., additional, Ottesen, A. H., additional, Louch, W. E., additional, Carlson, C., additional, Landsverk, O. J. B., additional, Stridsberg, M., additional, Sjaastad, I., additional, Oie, E., additional, Omland, T., additional, Christensen, G., additional, Rosjo, H., additional, Cartledge, J., additional, Clark, L. A., additional, Ibrahim, M., additional, Siedlecka, U., additional, Navaratnarajah, M., additional, Yacoub, M. H., additional, Camelliti, P., additional, Terracciano, C. M., additional, Chester, A., additional, Gonzalez-Tendero, A., additional, Torre, I., additional, Garcia-Garcia, F., additional, Dopazo, J., additional, Gratacos, E., additional, Taylor, D., additional, Bhandari, S., additional, Seymour, A.-M., additional, Fliegner, D., additional, Jost, J., additional, Bugger, H., additional, Ventura-Clapier, R., additional, Carpi, A., additional, Campesan, M., additional, Canton, M., additional, Menabo, R., additional, Pelicci, P. G., additional, Giorgio, M., additional, Di Lisa, F., additional, Hancock, M., additional, Venturini, A., additional, Al-Shanti, N., additional, Stewart, C., additional, Ascione, R., additional, Angelini, G., additional, Suleiman, M.-S., additional, Kravchuk, E., additional, Grineva, E., additional, Galagudza, M., additional, Kostareva, A., additional, Bairamov, A., additional, Krychtiuk, K. A., additional, Watzke, L., additional, Kaun, C., additional, Demyanets, S., additional, Pisoni, J., additional, Kastl, S. P., additional, Huber, K., additional, Maurer, G., additional, Wojta, J., additional, Speidl, W. S., additional, Varga, Z. V., additional, Farago, N., additional, Zvara, A., additional, Kocsis, G. F., additional, Pipicz, M., additional, Csonka, C., additional, Csont, T., additional, Puskas, G. L., additional, Ferdinandy, P., additional, Klevstigova, M., additional, Silhavy, J., additional, Manakov, D., additional, Papousek, F., additional, Novotny, J., additional, Pravenec, M., additional, Kolar, F., additional, Novakova, O., additional, Novak, F., additional, Neckar, J., additional, Barallobre-Barreiro, J., additional, Didangelos, A., additional, Yin, X., additional, Fernandez-Caggiano, M., additional, Drozdov, I., additional, Willeit, P., additional, Domenech, N., additional, Mayr, M., additional, Lemoine, S., additional, Allouche, S., additional, Coulbault, L., additional, Galera, P., additional, Gerard, J. L., additional, Hanouz, J. L., additional, Suveren, E., additional, Whiteman, M., additional, Studneva, I. M., additional, Pisarenko, O., additional, Shulzhenko, V., additional, Serebryakova, L., additional, Tskitishvili, O., additional, Timoshin, A., additional, Fauconnier, J., additional, Meli, A. C., additional, Thireau, J., additional, Roberge, S., additional, Lompre, A. M., additional, Jacotot, E., additional, Marks, A. M., additional, Lacampagne, A., additional, Dietel, B., additional, Altendorf, R., additional, Daniel, W. G., additional, Kollmar, R., additional, Garlichs, C. D., additional, Parente, V., additional, Balasso, S., additional, Pompilio, G., additional, Colombo, G., additional, Milano, G., additional, Squadroni, L., additional, Cotelli, F., additional, Pozzoli, O., additional, Capogrossi, M. C., additional, Ajiro, Y., additional, Saegusa, N., additional, Iwade, K., additional, Giles, W. R., additional, Stafforini, D. M., additional, Spitzer, K. W., additional, Sirohi, R., additional, Candilio, L., additional, Babu, G., additional, Roberts, N., additional, Lawrence, D., additional, Sheikh, A., additional, Kolvekar, S., additional, Yap, J., additional, Hausenloy, D. J., additional, Yellon, D. M., additional, Aslam, M., additional, Rohrbach, S., additional, Schlueter, K.-D., additional, Piper, H. M., additional, Noll, T., additional, Guenduez, D., additional, Malinova, L., additional, Ryabukho, V. P., additional, Lyakin, D. V., additional, Denisova, T. P., additional, Montoro-Garcia, S., additional, Shantsila, E., additional, Lip, G. Y. H., additional, Kalaska, B., additional, Sokolowska, E., additional, Kaminski, K., additional, Szczubialka, K., additional, Kramkowski, K., additional, Mogielnicki, A., additional, Nowakowska, M., additional, Buczko, W., additional, Stancheva, N., additional, Mekenyan, E., additional, Gospodinov, K., additional, Tisheva, S., additional, Darago, A., additional, Rutkai, I., additional, Kalasz, J., additional, Czikora, A., additional, Orosz, P., additional, Bjornson, H. D., additional, Edes, I., additional, Papp, Z., additional, Toth, A., additional, Riches, K., additional, Warburton, P., additional, O'regan, D. J., additional, Ball, S. G., additional, Turner, N. A., additional, Wood, I. C., additional, Porter, K. E., additional, Kogaki, S., additional, Ishida, H., additional, Nawa, N., additional, Takahashi, K., additional, Baden, H., additional, Ichimori, H., additional, Uchikawa, T., additional, Mihara, S., additional, Miura, K., additional, Ozono, K., additional, Lugano, R., additional, Padro, T., additional, Garcia-Arguinzonis, M., additional, Badimon, L., additional, Ferraro, F., additional, Viner, R., additional, Ho, J., additional, Cutler, D., additional, Matchkov, V., additional, Aalkjaer, C., additional, Krijnen, P. A. J., additional, Hahn, N. E., additional, Kholova, I., additional, Sipkens, J. A., additional, Van Alphen, F. P., additional, Simsek, S., additional, Schalkwijk, C. G., additional, Van Buul, J. D., additional, Van Hinsbergh, V. W. M., additional, Niessen, H. W. M., additional, Caro, C. G., additional, Seneviratne, A., additional, Monaco, C., additional, Hou, D., additional, Singh, J., additional, Gilson, P., additional, Burke, M. G., additional, Heraty, K. B., additional, Krams, R., additional, Coppola, G., additional, Albrecht, K., additional, Schgoer, W., additional, Wiedemann, D., additional, Bonaros, N., additional, Steger, C., additional, Theurl, M., additional, Stanzl, U., additional, Kirchmair, R., additional, Amadesi, S., additional, Spinetti, G., additional, Cangiano, E., additional, Valgimigli, M., additional, Miller, A. M., additional, Cardinali, A., additional, Vierlinger, K., additional, Pagano, G., additional, Liccardo, D., additional, Zincarelli, C., additional, Femminella, G. D., additional, Lymperopoulos, A., additional, De Lucia, C., additional, Koch, W. J., additional, Leosco, D., additional, Rengo, G., additional, Hinkel, R., additional, Husada, W., additional, Trenkwalder, T., additional, Di, Q., additional, Lee, S., additional, Petersen, B., additional, Bock-Marquette, I., additional, Niemann, H., additional, Di Maio, M., additional, Kupatt, C., additional, Nourian, M., additional, Yassin, Z., additional, Kelishadi, R., additional, Memarian, S. H., additional, Heidari, A., additional, Leuner, A., additional, Poitz, D. M., additional, Brunssen, C., additional, Ravens, U., additional, Strasser, R. H., additional, Morawietz, H., additional, Vogt, F., additional, Grahl, A., additional, Flege, C., additional, Marx, N., additional, Borinski, M., additional, De Geest, B., additional, Jacobs, F., additional, Muthuramu, I., additional, Gordts, S. C., additional, Van Craeyveld, E., additional, Herijgers, P., additional, Weinert, S., additional, Medunjanin, S., additional, Herold, J., additional, Schmeisser, A., additional, Braun-Dullaeus, R. C., additional, Wagner, A. H., additional, Moeller, K., additional, Adolph, O., additional, Schwarz, M., additional, Schwale, C., additional, Bruehl, C., additional, Nobiling, R., additional, Wieland, T., additional, Schneider, S. W., additional, Hecker, M., additional, Cross, A., additional, Strom, A., additional, Cole, J., additional, Goddard, M., additional, Hultgardh-Nilsson, A., additional, Nilsson, J., additional, Mauri, C., additional, Mitkovskaya, N. P., additional, Kurak, T. A., additional, Oganova, E. G., additional, Shkrebneva, E. I., additional, Kot, Z. H. N., additional, Statkevich, T. V., additional, Molica, F., additional, Burger, F., additional, Matter, C. M., additional, Thomas, A., additional, Staub, C., additional, Zimmer, A., additional, Cravatt, B., additional, Pacher, P., additional, Steffens, S., additional, Blanco, R., additional, Sarmiento, R., additional, Parisi, C., additional, Fandino, S., additional, Blanco, F., additional, Gigena, G., additional, Szarfer, J., additional, Rodriguez, A., additional, Garcia Escudero, A., additional, Riccitelli, M. A., additional, Wantha, S., additional, Simsekyilmaz, S., additional, Megens, R. T., additional, Van Zandvoort, M. A., additional, Liehn, E., additional, Zernecke, A., additional, Klee, D., additional, Weber, C., additional, Soehnlein, O., additional, Lima, L. M., additional, Carvalho, M. G., additional, Gomes, K. B., additional, Santos, I. R., additional, Sousa, M. O., additional, Morais, C. A. S., additional, Oliveira, S. H. V., additional, Gomes, I. F., additional, Brandao, F. C., additional, Lamego, M. R. A., additional, Fornai, L., additional, Kiss, A., additional, Giskes, F., additional, Eijkel, G., additional, Fedrigo, M., additional, Valente, M. L., additional, Heeren, R. M. A., additional, Grdinic, A., additional, Vojvodic, D., additional, Djukanovic, N., additional, Grdinic, A. G., additional, Obradovic, S., additional, Majstorovic, I., additional, Rusovic, S., additional, Vucinic, Z., additional, Tavciovski, D., additional, Ostojic, M., additional, Lai, S.-C., additional, Chen, M.-Y., additional, Wu, H.-T., additional, Gouweleeuw, L., additional, Oberdorf-Maass, S. U., additional, De Boer, R. A., additional, Van Gilst, W. H., additional, Maass, A. H., additional, Van Gelder, I. C., additional, Benard, L., additional, Li, C., additional, Warren, D., additional, Shanahan, C. M., additional, Zhang, Q. P., additional, Bye, A., additional, Vettukattil, R., additional, Aspenes, S. T., additional, Giskeodegaard, G., additional, Gribbestad, I. S., additional, Wisloff, U., additional, Bathen, T. F., additional, Cubedo, J., additional, Alonso, R., additional, Mata, P., additional, Ivic, I., additional, Vamos, Z., additional, Cseplo, P., additional, Kosa, D., additional, Torok, O., additional, Hamar, J., additional, Koller, A., additional, Norita, K., additional, De Noronha, S. V., additional, Sheppard, M. N., additional, Amat-Roldan, I., additional, Iruretagoiena, I., additional, Psilodimitrakopoulos, S., additional, Crispi, F., additional, Artigas, D., additional, Loza-Alvarez, P., additional, Harrison, J. C., additional, Smart, S. D., additional, Besely, E. H., additional, Kelly, J. R., additional, Yao, Y., additional, Sammut, I. A., additional, Hoepfner, M., additional, Kuzyniak, W., additional, Sekhosana, E., additional, Hoffmann, B., additional, Litwinski, C., additional, Pries, A., additional, Ermilov, E., additional, Fontoura, D., additional, Lourenco, A. P., additional, Vasques-Novoa, F., additional, Pinto, J. 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J., additional, Llacer, A., additional, Galasso, G., additional, Ferrara, N., additional, Akhmedov, A., additional, Klingenberg, R., additional, Brokopp, C., additional, Hof, D., additional, Zoller, S., additional, Corti, R., additional, Gay, S., additional, Von Eckardstein, A., additional, Hoerstrup, S. P., additional, Luescher, T. F., additional, Heijman, J., additional, Zaza, A., additional, Johnson, D. M., additional, Rudy, Y., additional, Peeters, R. L. M., additional, Volders, P. G. A., additional, Westra, R. L., additional, Fujita, S., additional, Okamoto, R., additional, Taniguchi, M., additional, Konishi, K., additional, Goto, I., additional, Sugimoto, K., additional, Nakamura, M., additional, Shiraki, K., additional, Buechler, C., additional, and Ito, M., additional
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- 2012
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38. On the mechanical strength of biocompatible semi-IPNs of polyvinyl alcohol and polyacrylamide
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Mishra, Shefali, primary, Bajpai, R., additional, Katare, R., additional, and Bajpai, A. K., additional
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- 2007
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39. EXAFS Studies of Some Copper(II) Mixed-Ligand Complexes
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Joshi, S. K., primary, Katare, R. K., additional, and Shrivastava, B. D., additional
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- 2007
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40. Radiation induced crosslinking effect on semi - interpenetrating polymer networks of poly(vinyl alcohol)
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Mishra, S., primary, Bajpai, R., additional, Katare, R., additional, and Bajpai, A. K., additional
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- 2007
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41. Evaluating Inter-/Intrazonal Isolation
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Tiwari, Anil Kumar, additional, Rajasekaran, Pitchai, additional, and Katare, R. P., additional
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- 2006
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42. Preparation and characterization of polyvinyl alcohol based biomaterials: Water sorption and in vitro blood compatibility study
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Mishra, Shefali, primary, Bajpai, R., additional, Katare, R., additional, and Bajpai, A. K., additional
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- 2006
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43. Development of polysaccharide-capped niosomes for oral immunization of tetanus toxoid
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Katare, R., primary, Gupta, P.N., additional, Mahor, S., additional, Rawat, A., additional, Khatri, K., additional, Katare, Y., additional, Panda, A.K., additional, and Vyas, S.P., additional
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- 2006
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44. X-ray absorption fine structure studies of some copper(II) mixed-ligand complexes with glutamic acid as primary ligand
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Katare, R. K., primary, Joshi, S. K., additional, Shrivastava, B. D., additional, Patel, R. N., additional, Pandeya, K. B., additional, and Mishra, A., additional
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- 2002
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45. K-Absorption spectral studies of some copper(II) mixed-ligand complexes
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Katare, R. K., primary, Joshi, S. K., additional, Shrivastava, B. D., additional, Pandeya, K. B., additional, and Mishra, A., additional
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- 2000
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46. Microhardness testing to detect radiation-induced crosslinking in polystyrene: Poly (methyl methacrylate) polyblends
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Katare, R., primary, Bajpai, R., additional, and Datt, S.C., additional
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- 1994
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47. Role for substance p-based nociceptive signaling in progenitor cell activation and angiogenesis during ischemia in mice and in human subjects.
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Amadesi S, Reni C, Katare R, Meloni M, Oikawa A, Beltrami AP, Avolio E, Cesselli D, Fortunato O, Spinetti G, Ascione R, Cangiano E, Valgimigli M, Hunt SP, Emanueli C, Madeddu P, Amadesi, Silvia, Reni, Carlotta, Katare, Rajesh, and Meloni, Marco
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- 2012
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48. Microhardness of blends of polystyrene and poly(methyl methacrylate)
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Katare, R., primary, Bajpai, R., additional, and Datt, S.C., additional
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- 1991
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49. Acetylcholine Inhibits the Hypoxia-Induced Reduction of Connexin43 Protein in Rat Cardiomyocytes
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Zhang Yanan, Kakinuma Yoshihiko, Ando Motonori, Katare Rajesh G, Yamasaki Fumiyasu, Sugiura Tetsuro, and Sato Takayuki
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Therapeutics. Pharmacology ,RM1-950 - Abstract
Abstract.: In a recent study, we demonstrated that vagal stimulation increases the survival of rats with myocardial infarction by inhibiting lethal arrhythmia through regulation of connexin43 (Cx43). However, the precise mechanisms for this effect remain to be elucidated. To investigate these mechanisms and the signal transduction for gap junction regulation, we investigated the effect of acetylcholine (ACh), a parasympathetic nerve system neurotransmitter, on the gap junction component Cx43 using H9c2 cells. When cells were subjected to hypoxia, the total Cx43 protein level was decreased. In contrast, pretreatment with ACh inhibited this effect. To investigate the signal transduction, cells were pretreated with L-NAME, a nitric oxide synthase inhibitor, followed by ACh and hypoxia. L-NAME was found to suppress the ACh effect. However, a NO donor, SNAP, partially inhibited the hypoxia-induced reduction in Cx43. To delineate the mechanisms of the decrease in Cx43 under hypoxia, cells were pretreated with MG132, a proteasome inhibitor. Proteasome inhibition produced a striking recovery of the decrease in the total Cx43 protein level under hypoxia. However, cotreatment with MG132 and ACh did not produce any further increase in the total Cx43 protein level. Functional studies using ACh or okadaic acid, a phosphatase inhibitor, revealed that both reagents inhibited the decrease in the dye transfer induced by hypoxia. These results suggest that ACh is responsible for restoring the decrease in the Cx43 protein level, resulting in functional activation of gap junctions. Keywords:: acetylcholine, connexin43, cardiomyocyte, hypoxia, proteasome inhibitor
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- 2006
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50. 289 Pharmacologic rejuvenation of senescent human cardiac stem cells enhances myocardial repair.
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Avolio, E, Gianfranceschi, G, Caragnano, A, Athanasakis, E, Katare, R, Meloni, M, Beltrami, CA, Cesselli, D, Madeddu, P, and Beltrami, AP
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STEM cells ,CELLULAR aging ,REJUVENATION ,ION channels ,HEART transplantation ,CELLULAR signal transduction - Abstract
Purpose: Cellular senescence associated with ageing and disease hampers the functional properties of human c-Kit+ Cardiac Stem Cells (CSC) in vitro. Aim of the study was to identify molecular mechanisms associated with CSC senescence and to pharmacologically modulate this latter, at the aim to improve the therapeutic potential of CSC in vivo.Methods: c-Kit+ CSC were isolated from atrial specimens of end-stage failing hearts (E-CSC, n=20) and hearts donated for transplantation (D-CSC, n=14). D- and E-CSC were compared in vitro for the expression of senescence markers and secretome. The ability of CSC's secretome to protect rat adult cardiomyocytes (CM) in vitro from a simulated ischemia-reperfusion injury was analysed. 3 molecular signalling pathways associated with cell senescence were investigated. A 3-days pharmacologic treatment with a cocktail of 10nM Rapamycin and 0.5μM Resveratrol was employed to revert E-CSC senescence in vitro. The functional recovery of SCID-Beige mice infarcted hearts injected with Vehicle (n=17), D-CSC (n=17), E-CSC (n=18) or drug-conditioned-E-CSC (n=18) (300,000 cells/heart) was compared 14 days post-transplantation.Results: with respect to D-CSC, E-CSC show, in vitro, higher levels of senescence markers (p16, γH2AX), a blunted proliferation and a secretome strongly enriched in the pro-inflammatory IL-1β, unable to protect rat CM from apoptosis and senescence in vitro. Neutralisation of IL-1β restored E-CSC's secretome protective effect. At the molecular level, E-CSC are characterized by an hyper-activation of the canonical NFB pathway and of Caspase1, an increased activity of the TORC1 complex, an impairment of the authophagic flux and a reduction of AMPK, Akt and CREB activation. All these alterations could be successfully reverted employing a cocktail of Rapamycin and Resveratrol. The drug treatment reduced the fraction of senescent E-CSC and the amount of IL-1β secreted in vitro, thus restoring the protective effect on rat CM. Last, D-CSC but not E-CSC were able to enhance myocardial healing when injected in a mouse infarcted heart. However, the ex vivo preconditioning of E-CSC with Rapamycin and Resveratrol, prior to the in vivo transplantation, restored their reparative potential to D-CSC levels.Conclusions: we first demonstrate that senescent c-Kit+ CSC resident in human failing hearts display an impaired in vivo reparative ability; importantly, senescent CSC can be rejuvenated in vitro with a short pharmacologic conditioning, finally boosting the in vivo cardiac regeneration. These findings open new avenues to improve autologous CSC therapy in heart failure. [ABSTRACT FROM PUBLISHER]
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- 2014
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