28 results on '"Katanić, Nataša"'
Search Results
2. Antimicrobial treatment of Acinetobacter neuii invasive infections: A systematic review
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Milentijević Milica N., Katanić Nataša, Aritonović-Pribaković Jelena, Kočović Aleksandar G., Milosavljević Jovana Z., Milosavljević Miloš N., Stefanović Srđan M., and Ivković Đorđe
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actinomyces neuii ,invasive infections ,antibiotics ,therapy ,systematic review ,Medicine - Abstract
Aims: The objectives of this study were to find out whether and to what extent Actinomyces neuii is pathogenic to humans in terms of causing invasive infections and to ascertain the most appropriate and effective antibiotic therapy against this bacterium. Material and method: This study was designed as a systematic review article. MEDLINE, Google Scholar, SCIndex, Cochrane database of published clinical trials - Central and Clinicaltrials.gov databases were systematically searched for primary case reports or case series describing invasive infection with Actinomyces neuii. Results: A literature search identified 23 studies that met the inclusion criteria, describing cases of patients with an invasive infection caused by Actinomyces neuii. It was found that A. neuii could cause endocarditis, endophthalmitis, osteomyelitis, pleural empyema, soft tissue abscesses, neonatal sepsis, ventriculoperitoneal shunt infections and periprosthetic tissue infections. The most prescribed antibiotics for the treatment of Actinomyces neuii infections were amoxicillin and vancomycin (n = 10; 12.3%), followed by penicillin (n =9; 11.1%), gentamicin (n = 6; 7.4%), ampicillin (n = 5; 6.2%) and ceftazidime (n = 4; 4.9%). Antibiotic treatment of infections caused by A. neuii was followed by clinical improvement or complete cure of all patients, with no recorded deaths. Conclusion: A. neuii has a relevant pathogenic potential to cause invasive infections of various organs and tissues, especially in immunocompromised individuals of any age. For the treatment of mild infections caused by this bacterium, the antibiotics of choice are penicillin or amoxicillin, while vancomycin should be used to treat severe infections caused by Actinomyces neuii.
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- 2020
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3. Efficacy and safety of pegylated-interferon alpha therapy in patients with chronic hepatitis B in recource-limited settings- Serbian single-center experience
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Bojović Ksenija, Jordović Jelena, Simonović-Babić Jasmina, Delić Dragan, Mitrović Nikola, and Katanić Nataša
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biochemistry ,hepatitis b ,antigens ,hepatitis b, chronic ,peginterferon alfa-2 ,treatment outcome ,virology ,Medicine (General) ,R5-920 - Abstract
Background/Aim. In Serbia, pegylated interferon (PEGIFN) alpha-2a has been registered since 2013 for the treatment of patients with chronic hepatitis B (CHB). Numerous advantages, new experiences during the past five years and lack of any published data in our specific population, have initiated this study, with the aim to examine efficacy and safety of PEG-IFN in patients in a Serbian referral center. Methods. This prospective study included 36 patients with CHB who were treated in the Hepatology Department of the Clinic for Infectious and Tropical Diseases, Clinical Center of Serbia in Belgrade, during 2012–2017. Patients had a standard 48-week treatment protocol with PEG-IFN, with measurements of liver enzymes, serology and viraemia before, during, at the end of the treatment and follow-up 6 months afterwards. Treatment outcome was determined using serology (clearance of HBeAg), biochemical [normalization of alanine aminotransferase (ALT)] and virological response [hepatitis B virus (HBV) DNA < 2,000 IU/mL]. Results. Virological success in patients with HBeAg positive CHB was achieved in 50% of patients, HBeAg clearance in 62.5%, and normalization of ALT in 37.5% of patients. In patients with HBeAg negative CHB, 38% of the patients achieved virologic success, biochemical success was obtained in 47.6% of the patients and only one (4.7%) patient had HBsAg clearance. Conclusion. PEG-IFN is important for treatment of patients with CHB in well-defined situations, and in our population success rates are similar to other published studies. Although safety and tolerability are satisfactory, there is a possibility of more serious side-effects so it is necessary to monitor patients regularly during the treatment.
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- 2020
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4. Severe imported malaria in a Serbian referral center
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Poluga Jasmina, Karić Uroš, Dakić Zorica, Katanić Nataša, Lavadinović Lidija, Milošević Branko, Nikolić Nataša, Urošević Aleksandar, Jegorović Boris, and Pavlović Milorad
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malaria ,tumor necrosis factor-alpha ,thrombocytopenia ,severity of illness index ,serbia ,Medicine (General) ,R5-920 - Abstract
Background/Aim. The World Health Organization estimates that 3.2 billion people are at a risk of being infected with malaria. Thus, the adequate diagnostic protocols for malaria, especially those aimed at determining disease severity, are paramount both in endemic and non-endemic setting. The aim of this study was to identify the demographic, parositological, clinical and laboratory characteristics associated with severe malaria in a non-endemic settings. Methods. We analyzed 22 patients with severe malaria and compared their clinical and laboratory findings with those of the patients with non-severe malaria in a search of predictors of disease severity. All patients were treated at the Infectious and Tropical Diseases University Hospital, Clinical Centre of Serbia in Belgrade, Serbia from 2000 to 2010. Results. The average age of patients with with severe malaria was 44.86 ± 12.33 years and men predominated (95.45%). The patients with severe malaria were infected Plasmodium falciparum (P. falciparum) significantly more frequently compared with those with non-severe disease (p =0.047). Jaundice was the most commonly observed feature of severe malaria, followed by anemia and renal failure. The multifactor analysis of variance showed that thrombocytopenia (p = 0.05) and high serum tumor necrosis factor-alpha levels (p = 0.02) were significantly associated with the disease severity. Conclusion. A high index of suspicion for malaria should be maintained when evaluating febrile patients returning from the malaria endemic regions. The elevated serum tumor necrosis factor-alpha levels and thrombocytopenia are associated with severe malaria in non-endemic settings.
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- 2019
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5. Herpes zoster - is there a need for new treatment recommendations?
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Karić Uroš, Katanić Nataša, Peruničić Sanja, Mitrović Nikola, Nikolić Nataša, Marković Marko, Bojović Ksenija, Malinić Jovan, Poluga Jasmina, and Simonović-Babić Jasmina
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varicella zoster virus infection ,recurrence ,drug users ,treatment outcome ,Medicine (General) ,R5-920 - Abstract
Background/Aim. The reactivation of the varicella zoster virus results in herpes zoster. Acyclovir is currently recommended over 7 to 10 days for herpes zoster treatment and should be started within 72 hours of rash eruption. This study analyses whether a therapy delay and/or shorter courses of treatment are associated with adverse outcomes. Methods. We identified 292 patients treated at the Clinic for Infectious and Tropical Diseases in Belgrade for herpes zoster in a five-years period. The data on these patients were analyzed using the descriptive statistics, the χ2 test, the Mann-Whitney U-test and the multiple logistic regression analysis. Results. The average time from rash eruption to the first dose of acyclovir was 4.07 ± 2.64 days. The patients received acyclovir for 6.83 ± 2.45 days. Seventy-one patients had disseminated herpes zoster, 100 had cranial nerve involvement, 86 had complications other than postherpetic neuralgia and one patient died. In cases where therapy was delayed there was no significant association with complications (χ2 = 0.031; p = 0.86). Our logistic regression model was not able to predict who was treated less than 7 days. An association between the HZ complications and abbreviated acyclovir regimens was not demonstrated (χ2 = 1.109; p = 0.326). We conducted the PubMed search on February 1st, 2017 and found no proof for the need to apply at least 7 days of acyclovir therapy for herpes zoster in the studies that have been published so far. Conclusion. We were unable to prove an association between therapy delay and unfavorable outcomes. The same was true for shorter than recommended acyclovir courses.
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- 2019
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6. Alteration in microcrustacean secondary production and herbivory effects between the River Danube and its floodplain lake
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Galir Balkić, Anita, Ternjej, Ivančica, and Katanić, Nataša
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- 2019
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7. Urinary tract infections in children and pathogen resistance to antimicrobial drugs
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Stolić Boban, Katanić Radoslav, Katanić Nataša, Odalović Dragica, Pribaković-Aritonović Jelena, Odalović Andrijana, Stolić Aleksandar, Radomirović Danica, Vujačić Mirjana, and Ilić Vanja
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children ,urinary tract infections ,resistance ,antibiotic ,Medicine - Abstract
Introduction: Urinary tract infections are one of the most common infections in young children. Febrile conditions in young children, without specific clinical signs and symptoms are often the result of ITU. Usually later diagnosed and treated. The most common cause of ITU is Escherichia coli. The main problem in the treatment of ITU is increasing resistance to antibiotics. AIM: To point out all the frequent resistance to antibiotics and to compare the frequency of the experimental periods. Material and methods: We performed a retrospective study in the period of 2010-2015. Urine samples for microbiological examination were taken before switching on antibiotics. Statistical analysis was performed in SPSS software. RESULTS: In our study found 183 patients with a diagnosis of ITU. Somewhat higher percentage were present, patients were female. The highest resistance to ampicillin was found in our results in the time period is 5 years, found a drop resistance Amoxicilin and Amoksiklav. DISCUSSION: Our results showed a strong similarity with the works on the same theme, which is Escherichia coli, the most common cause of ITU in young children. ITU are represented within the female population. CONCLUSION: It is important to continuously monitor the representation of urinary tract infections as well as their sensitivity to antimicrobial drugs, because of the increasing presence of the bacterial resistance to existing antibiotics.
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- 2018
8. Isolation of Borrelia lusitaniae from the blood of a patient with multiple erythema migrans
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Tomanović, Snežana, Tomanović, Snežana, Veinović, Gorana, Malinić, Jovan, Sukara, Ratko, Mihaljica, Darko, Nikolić, Nataša, Katanić, Nataša, Poluga, Jasmina, Tomanović, Snežana, Tomanović, Snežana, Veinović, Gorana, Malinić, Jovan, Sukara, Ratko, Mihaljica, Darko, Nikolić, Nataša, Katanić, Nataša, and Poluga, Jasmina
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Tropical Diseases of the University Clinical Centre of Serbia with a clinical presentation of disseminated erythema migrans. The patient and the mother could not recall if there had been a tick bite. A sample of blood was taken, and antibiotic therapy with amoxicillin was started immediately. Human serum sample was checked for the presence of IgM antibody against Borrelia burgdorferi sensu lato by commercial ELISA test and the sample was positive for IgM. Blood was collected into the sterile K2EDTA tube, immediately transported to the Laboratory at the Institute for Medical Research, National Institute of the Republic of Serbia, University of Belgrade, and centrifuged twice at 2200 rpm for 17 min at room temperature. After centrifugation, one part of the serum was served for DNA extraction using ammonium hydroxide, ethanol, and sodium acetate while the sediment was inoculated into a 6 mL tube with Barbour-Stoenner-Kelly-H (BSK-H) medium under aseptic conditions and incubated as 33°C. After 16 days of incubation, viable, motile, and spiral-shaped microorganisms were observed in the initial BSK-H culture under dark-field microscopy, and incubation was prolonged for 29 days. DNA from the culture was extracted using centrifugation, dissolving the sediment in the water, and heating at 95°C for 10 minutes. After extracting DNA from the human serum and the culture, rrf-rrl rDNA intergenic spacer and flagellin gene (flaB) were amplified by conventional PCR, and sequencing of obtained PCR products was performed commercially (Macrogen, Amsterdam, the Netherlands). After analysis of the sequences obtained, Borrelia lusitaniae was confirmed in human serum and culture. This is the first isolate of B. lusitaniae from a human blood sample that confirms that B. lusitaniae can disseminate via the hematogenous route.
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- 2023
9. Abdominal actinomycosis 'imitator' of colon cancer
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Katanić Nataša, Bojović K., Milošević I., Lavadinović L., Aritonović J., Odalović A., and Malinić J.
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actinomycosis ,abdominal infection ,Medicine - Abstract
We present a single case of abdominal actinomycosis occurring in a 52-year-old female with a two months history of illness before presentation. Abdominal actinomycosis is a rare, chronic, granulomatous infection characterized by the release of 'sulphur granules'. Actinomyces species should always be part of the differential diagnosis of patients presenting with a history of surgical or invasive procedures, presenting with an abdominal mass. Diagnosis is often difficult. In less than 10% of cases, the diagnosis is made preoperatively. Definitive diagnosis is often based on histochemical, macroscopic, and microscopic examination of tissue specimens. The disease should be treated with high doses of intravenous penicillin for 2-6 weeks followed by oral therapy for at least 6-12 months.
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- 2014
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10. Varicella complications: Is it time to consider a routine varicella vaccination?
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Dulović Olga, Gvozdenović Eleonora, Nikolić Jelena, Radovanović-Spurnić Aleksandra, Katanić Nataša, and Kovačević-Pavićević Dragana
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chickenpox ,disease progression ,pneumonia, viral ,skin diseases, bacterial ,central nervous system diseases ,sepsis ,vaccination ,Medicine (General) ,R5-920 - Abstract
Background/Aim. Varicella is a common and benign disease of childhood. Complications are rare, but in some patients, even without risk factors, severe, life threatening complications could be seen. The aim of this study was to establish the type and frequency of varicella complications among hospitalized patients over an 8-year period. Methods. This retrospective analysis included medical charts of the patients hospitalized in the Infectious Disease Clinic, Belgrade, Serbia, from 2001-2008 (4.85% of all registered patients with varicella in Belgrade, 2001-2008). Among hospitalised patients dermografic characteristics were analyzed: hospitalisation lenght, presence and type of complications, presence of immunocompromising conditions and outcome of the disease. The diagnosis of varicella was made on clinical grounds, and in persons > 40 years, with negative epidemiological data of contacts, serological confirmation (ELISA VZV IgM/IgG BioRad®) and avidity of IgG antibodies were done to exclude the possibility of disseminated herpes zoster. Results. A total of 474 patient were hospitalized over an 8-year period. The age of patients was from 5 months to 75 years (mean 22.4 ± 16.1, median 23.5 years). The majority of patients were adults (n = 279; 58.9%) and 195 (41.1%) patients were ≤ 15 years old. Complications were found in 321/474 (67.7%) patients. The registered complications were: varicella pneumonia (n = 198; 41.38%), bacterial skin infections (n = 40; 8.4%), cerebelitis (n = 28; 5.9%), bacterial respiratory infection (n = 21; 4.4%), viral meningitis (n = 10; 2.31%), encephalitis (n = 9; 1.9%), thrombocytopenia (n = 2; 0.4%); 11 (2.3%) patients had more than one complication, among them were sepsis, myopericarditis and retinal hemorrhages. When complications were analyzed according to the age, there were no statistical significance, but when type of complication was analyzed statistical significance was found (p < 0.05). In adults, pneumonia was the most common complication: 173/279 (62%), followed by skin infections (2.9%), bacterial respiratory infections (2,2%), and more than one complication (2.3%). Pneumonia was more common in adults than in children (7 : 1). In children skin infections were the most common complications (16.4%), followed by cerebelitis (13.3%), viral pneumonia (12.8%), bacterial respiratory infections (7.7%), encephalitis (3.6%), and more than one complication (4.1%). Neuroinfections were more common in children than in adults (6:1), as well as bacterial skin infections (4 : 1). Two patients died (0,4%). Conclusion. There was no difference in the incidence of varicella complication in children and adults, but the type of complication differed. In children the most common complications were skin and neurological infections, while in adults it was varicella pneumonia. These data provide a baseline for estimating the burden of varicella in Belgrade and support the inclusion of varicella vaccine in childhood immunisation program in Serbia.
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- 2010
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11. Erysipelas in a cat-bite victim caused by 'Pasteurella multocida': Case report
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Gvozdenović, Eleonora, primary, Malinić, Jovan, additional, Nikolić, Nataša, additional, Katanić, Nataša, additional, Jovanović, Milica, additional, and Dulović, Olga, additional
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- 2022
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12. Photosynthetic Efficiency in Flag Leaves and Ears of Winter Wheat during Fusarium Head Blight Infection
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Katanić, Zorana, primary, Mlinarić, Selma, additional, Katanić, Nataša, additional, Ćosić, Josipa, additional, and Španić, Valentina, additional
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- 2021
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13. Fotosinteza pšenice zaražene fuzarijskom paleži klasa
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Katanić, Zorana, Mlinarić, Selma, Ćosić, Josipa, Katanić, Nataša, Drezner, Georg, Španić, Valentina, Rozman, Vlatko, and Antunović, Zvonko
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biotički stres, Fusarium, fluorescencije klorofila a, fotosintetska učinkovitost, Triticum aestivum ,food and beverages ,sense organs - Abstract
Fusarium head blight (FHB) is a serious disease of wheat (Triticum aestivum L.) which can reduce yield and quality of the grain. In order to investigate effect of FHB on photosynthesis of winter wheat varieties with different susceptibility, artificial inoculation with Fusarium graminearum and F. culmorum (1:1) was performed in the field at the Agricultural Institute Osijek in 2019/2020. Analysis of fast chlorophyll a fluorescence transients of flag leaf and ear revealed that more significant changes in photosynthetic efficiency due to FHB occurred in ears, in comparison to leaves. Decrease of performance index (PIABS) and maximum quantum yield of PS II (TR0/ABS) in the inoculated ears, in comparison to control (natural infection) of variety Golubica was detected three days post inoculation, indicating that changes in photosynthetic apparatus of this susceptible variety occurred before visual symptoms of the infection. Upon symptom development, inoculated ears of Golubica showed increase of PIABS and TR0/ABS, while progression of the disease resulted in reduced photosynthetic performance, in comparison to control. Impact of FHB on ear photosynthetic efficiency of resistant variety (Galloper) was also evident, especially in the later stages of the infection, but it was less severe than for variety Golubica. Overall, this study indicated that Fusarium sp. infection may induce changes in photosynthetic performance and functioning of PSII in ears of wheat.
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- 2021
14. Utjecaj temperaturnih ekstrema na proljetno – ljetni razvoj zajednice zooplanktona
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Katanić, Nataša
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rašljoticalci, veslonošci, poplavna područja, sezonske sukcesije - Abstract
Planktonski rakovi zauzimaju ključni trofički položaj unutar slatkovodne hranidbene mreže, a njihov razvoj ovisan je o temperaturi. Cilj provedenog istraživanja bio je utvrditi imaju li zabilježene normalne i ekstremne temperature u proljetnom (travanj – lipanj) i ljetnom razdoblju (srpanj – rujan) 2012., 2013. i 2016. godine utjecaj na kvalitativni i kvantitativni sastav zajednice planktonskih rakova u jezeru Sakadaš (Park prirode Kopački rit). Uzorci vode za hidrobiološke analize prikupljeni su iz površinskog sloja jezera Sakadaš mjesečnom dinamikom. Struktura zajednice zooplanktona opisana je indeksima, a vrijednosti mjerenih fizikalno – kemijskih čimbenika uspoređene su statistički primjenom t-testa i jednosmjerne analize varijance. Zajednicom rašljoticalaca dominirale su manje forme, dok su zajednicom veslonožaca dominirali ciklopoidni veslonošci i njihovi razvojni stadiji. Brojnost i biomasa planktonskih rakova značajno su se razlikovale između proljeća i ljeta pri čemu su veće vrijednosti zabilježene u proljeće. Istraživanjem je utvrđeno da temperatura utječe na sezonske sukcesije i može doprinositi međugodišnjim varijabilnostima u sastavu zajednice, no značajniji je indirektan utjecaj kroz dostupnost hranjivih tvari i predaciju. Istovremeno s temperaturom značajan utjecaj su imali prozirnost, koncentracija klorofila-a te koncentracija dušika.
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- 2020
15. Uticaj stabilnog virusološkog odgovora na tok i ishod bolesti kod pacijenata sa teškom fibrozom ili cirozom jetre uzrokovanom hroničnom hepatitis C virusnom infekcijom
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Delić, Dragan, Simonović-Babić, Jasmina, Bojović, Ksenija, Katanić, Nataša, Jordović, Jelena, Delić, Dragan, Simonović-Babić, Jasmina, Bojović, Ksenija, Katanić, Nataša, and Jordović, Jelena
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Hepatitis C virus (HCV) je, globalno posmatrano, najčešći uzročnik hroničnog virusnog hepatitisa sa dugogodišnjim progresivnim tokom, varijabilnom kliničkom slikom i često nepredvidivim ishodom. Naša drţava spada u grupu zemalja sa intermedijernom zastupljenošću HCV infekcije, tj. prevalencijom od 0,19% meĎu dobrovoljnim davaocima krvi i procenjenom prevalencijom od 1,13% na nivou Srbije. U našoj zemlji postoji višedecenijsko iskustvo u dijagnostici i lečenju pacijenata sa HCV infekcijom, ali osim kliničkih opservacija, nema objavljenih podataka o dugoročnom ishodu kod ovih pacijenata. U terapijskom i prognostičkom smislu najzahtevniju grupu predstavljaju pacijenti kod kojih se HCV infekcija otkrije u fazi uznapredovalog oštećenja jetre (fibroze ili ciroze), najčešće zbog višedecenijskog asimptomatskog toka bolesti, ali i zbog neadekvatnih mera skrininga, posebno u populacijama pod povećanim rizikom. U ovoj grupi pacijenata, čak i nakon terapijskog uspeha i postizanja nedetektibilne viremije (bez obzira na vrstu korišćenog terapijskog protokola), postoji rizik od nastanka nepovoljnih ishoda-uključujući virusološki i biohemijski relaps, dekompenzaciju jetre i pojave hepatocelularnog karcinoma (HCC). Višedecenijsko iskustvo u primeni kombinovane antivirusne terapije pegilovanim interferonom (PEG-IFN) i ribavirinom je pokazalo da postizanje stabilnog virusološkog odgovora (SVR) značajno redukuje morbiditet i mortalitet u grupi pacijenata sa teškim preterapijskim oštećenjem jetre. Pored toga, kliničke opservacije i literaturni podaci stranih autora govore u prilog potrebi za nastavkom praćenja ove grupe pacijenata i redovnim skriningom na HCC, čak i u slučaju odrţavanja nedetektibilne viremije i/ili regresije fibroze. Multikauzalna priroda, individualan tok bolesti i često nepredvidiv dugoročni ishod u ovoj grupi pacijenata, čak i nakon trajne supresije viremije, a u odsustvu preporuka o duţini praćenja i bilo kakvih publikovanih podataka u našoj zemlji, predmet su pose, Hepatitis C virus (HCV) is the most common worldwide cause of chronic viral hepatitis with a long-term progression, variable clinical presentation and outcome. Serbia is a country with an intermediary prevalence of HCV infection, estimated around 0,19% among blood donors and aproximately 1,13% in the general population of Serbia. In spite of two decades of diagnostic and therapeutic experiences with clinical observances, there are no published data concerning long-term prognosis and outcome in these patients. Patients with baseline liver fibrosis and cirrhosis present the most challenging group of patients, and are mostly underdiagnosed due to the asymptomatic nature of the disease and insufficient screening, especially in certain groups of patients. In this particular group, even after treatment success and HCV supression, remains a risk of unfavourable outcomes including virological and biochemical relapse, adverse clinical outcomes and hepatocellular carcinoma (HCC). Although sustained virological response (SVR) undoubtedly reduces liver-related morbidity and mortality in patients with severe baseline liver damage, clinical observance and published data show that these patients need continuous monitoring and HCC screening in spite of HCV supression and/or fibrosis regression. AIM: Main purpose of this study was to examine reliability and durability of SVR, as a predictor of treatment success and long-term outcome in patients with HCV related severe baseline liver injury. PATIENTS AND METHODS: A cohort study included 325 patients with HCV related severe baseline liver injury, who completed treatment protocol with pegylated interferon and ribavirin from January 2003. until November 2011. at the Hepatology department of the Clinic for Infectious And Tropical Diseases, Clinical Center of Serbia. After treatment completion, patients were followed and endpoints were December 2015, death outcome or the date of the last checkup. Inclusion criteria included: chronic hepat
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- 2020
16. IL-28B genotypes as predictors of long-term outcome in patients with hepatitis C-related severe liver injury
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Jordović, Jelena, Simonović-Babić, Jasmina, Gašić, Vladimir, Kotur, Nikola, Zukić, Branka, Pavlović, Sonja, Lazarević, Ivana, Karalić, Danijela, Katanić, Nataša, Nikolić, Nataša, Urosević, Aleksandar, Nestorov, Jelena, Delić, Dragan, Bojović, Ksenija, Jordović, Jelena, Simonović-Babić, Jasmina, Gašić, Vladimir, Kotur, Nikola, Zukić, Branka, Pavlović, Sonja, Lazarević, Ivana, Karalić, Danijela, Katanić, Nataša, Nikolić, Nataša, Urosević, Aleksandar, Nestorov, Jelena, Delić, Dragan, and Bojović, Ksenija
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Introduction: Patients with severe fibrosis or cirrhosis are at high risk for liver-related complications, even after successful antiviral treatment and/or regression of fibrosis. These are the first published results concerning the role of IL-28B genotypes as predictors of the durability of sustained virological response (SVR) and long-term outcome, in patients with baseline severe fibrosis and cirrhosis caused by hepatitis C (HCV) infection. Methodology: Genetic testing for three different single nucleotide polymorphisms (SNP) near the IL28B gene, rs12979860, rs12980275 and rs8099917, was performed in 42 patients with HCV-related advanced fibrosis and cirrhosis, who achieved SVR after successful interferon-based treatment. Baseline clinical and laboratory parameters were analysed, as well as IL28B genotype association with late virological relapse, fibrosis progression and clinical outcomes. Results: The most prevalent genotypes in all three tested SNP positions were: CCrs12979860 genotype in 69% of patients, GT(rs)(8099917) in 78.6% and GG(rs)(12980275) in 47.6% of patients. The presence of IL28B CCrs12979860 genotype was identified as a negative predictor of late virological relapse. Further analysis did not confirm the association of other IL28B genotypes with the progression of fibrosis and clinical outcomes. Conclusions: Varying long-term prognosis in patients with HCV-related severe fibrosis and cirrhosis is due to multiple interactions between host genetic factors, virus and environment. These are first published results demonstrating the significance of IL28B CCrs12979860 genotype as a negative predictor of late virological relapse. A further investigation concerning genetic factors is necessary to identify patients under risk for late relapse, complications and unfavorable outcomes, so that they can be reevaluated and offered new treatment options.
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- 2019
17. Sekundarna produkcija zooplanktona unutar hidrološki dinamičnih staništa
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Galir Balkić, Anita, Ternjej, Ivančica, Katanić, Nataša, Ozimec, Siniša, Bogut, Irella, Rožac, Vlatko, Stević, Filip, Popović, Željko, Bolšec, Boris, Baković, Adrijana, and Vereš, Marija
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Cladocera ,Copapoda ,poplavno jezero ,Dunav ,P/B index - Abstract
Brojnost zooplanktona i vrsni sastav zajednice značajno variraju između rijeke i poplavnih područja pri čemu osciliraju i vrijednosti sekundarne produkcije (P/B). S obzirom da na P/B index utječu i masa tijela, reprodukcijski kapacitet jedinke, rast i razvoj organizma, životni vijek, kompeticija i predacija, P/B indeks se može koristiti u procjeni odgovora populacije na promijenjene uvjete okoliša. Glavni cilj provedenog istraživanja bio je utvrditi utjecaj izmjene vodostaja na sekundarnu produkciju planktonskih rakova u rijeci Dunav (RD) i poplavnom jezeru Sakadaš (LS). Istraživanje je provedeno tijekom 2010. i 2011. godine mjesečnom dinamikom. Brojnost jedinki i vrsni sastav zooplanktona značajno se razlikovao među istraživanim lokalitetima pri čemu su obje vrijednosti bile veće u LS nego u RD. Povremena povećanja broja jedinki u RD uslijedila su nakon povišenih vodostaja što je uzrokovano efektom ispiranja planktonskih zajednica. SEM analizom utvrđeno je da su promjene vodostaja pozitivno korelirale sa strukturom zajednice u LS dok je zabilježen negativan utjecaj u RD, vjerojatno kao posljedica povećanog protoka vode koji onemogućava razvoj zooplanktona. P/B indeks se značajno razlikovao među ispitivanim lokalitetima (t-test: -3.95, p ˂ 0.001) pri čemu je znatno veća vrijednost zabilježena u poplavnom jezeru. Ovaj rezultat odraz je moguće učinkovitijeg prijenosa energije na više trofičke nivoe, kao posljedica velike količine nutritivno bogate hrane. Promjena u strukturi zajednice negativno je utjecala na P/B na oba istraživana lokaliteta iako je utjecaj bio značajno veći u LS (t-test: 4.16, p ˂ 0.001) kao rezultat snažnije oscilacije u strukturi zajednice tijekom vremena. Zaključno, iako je SEM analizom utvrđen slab direktan utjecaj vodostaja na strukturu zajednice planktonskih rakova, abiotički čimbenici, koji su značajno oscilirali s promjenama vodostaja i među ispitivanim lokalitetima, snažno su utjecali su na strukturu zajednice i posljedično na P/B index. Dok su u poplavnom jezeru na sekundarnu produkciju primarno utjecali biotički parametri (najznačajnije brojnost zajednice), abiotički čimbenici (temperatura) su ih zamijenili u rijeci Dunav. Dobiveni rezultati pokazuju da je P/B indeks osjetljiv indikator odgovora populacije zooplanktona i stoga se može upotrebljavati u procjeni promjena stanja različitih vodenih tijela.
- Published
- 2018
18. Ispitivanje efikasnosti peroralno primenjenog teikoplanina u farmakoterapiji teških, komplikovanih i refraktarnih oblika Clostridium difficile infekcije
- Author
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Korać, Miloš, Nešić, Zorica, Gojković-Bukarica, Ljiljana, Milošević, Ivana, Katanić, Nataša, Popović, Nataša A., Korać, Miloš, Nešić, Zorica, Gojković-Bukarica, Ljiljana, Milošević, Ivana, Katanić, Nataša, and Popović, Nataša A.
- Abstract
Clostridium difficile je najčešći uzročnik postantibiotske dijareje i pseudomembranoznog kolitisa. Nekada sporadična infekcija, poslednjih petnaest godina dobija razmere globalne epidemije i postaje jedna od vodećih intrahospitalnih infekcija u svetu i značajan uzrok smrti naročito među starijima od 65 godina. Porast broja obolelih, kao i sve veći broj bolesnika sa teškom kliničkom slikom i komplikacijama te sve češća pojava recidiva i slučajeva refraktarnih na standardnu terapiju vezuju se za razvoj hipervirulentnog soja bakterije, NAP1/BI/027. Spektar kliničkih oblika C. difficile infekcije obuhvata blagu do umerenu bolest u vidu dijareje bez kolitisa, tešku i tešku komplikovanu formu koja se karakteriše pojavom ileusa, toksičnog megakolona, hipotenzije sa primenom vazopresora, organskom disfunkcijom, izmenjenim mentalnim statusom, leukocitozom ≥ 35000/mm3 ili leukopenijom < 2000/mm3. Glavni problem u svakodnevnom kliničkom radu sa obolelima od C. difficle infekcije predstavlja velika učestalost recidiva bolesti, kao i sve češća pojava refraktarnih slučajeva. Standardnu terapiju C. difficile infekcije čine metronidazol i vankomicin, a poslednjih godina i fidaksomicin, čijim primenom je samo delimično smanjen rizik od recidiva. U ranije sprovedenim istraživanjima o primeni teikoplanina u lečenju C. difficile infekcije teikoplanin se pokazao kao uspešan, međutim, ova istraživanja su sprovedena u vreme pre pojave hipervirulentnog soja i „epidemije“ C. difficile infekcije i obuhvatala su mali broj ispitanika. CILJ: Cilj ovog istraživanja bio je da se ispita i uporedi ishod C. difficile infekcije kod bolesnika sa teškom formom bolesti lečenih teikoplaninom i vankomicinom u pogledu postignutog procenta kliničkog izlečenja, vremena od početka terapije do prestanka proliva, smrtnosti kao i učestalosti recidiva nakon 8 nedelja praćenja. Drugi cilj je bio da se utvrdi efikasnost peroralno primenjenog teikoplanina (u pogledu kliničkog izlečenja, smrtnosti, vremena od početka
- Published
- 2018
19. NITRATES AND NITRITES SIGNIFICANCE IN THE DEVELOPMENT OF ALCOHOLIC LIVER DISEASE
- Author
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Ničković, Vanja, primary, Katanić, Radoslav, additional, and Katanić, Nataša, additional
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- 2018
- Full Text
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20. CHRONIC HEPATITIS B
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Ničković, Vanja, primary, Katanić, Radoslav, additional, Katanić, Nataša, additional, and Kocić, Ilija, additional
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- 2017
- Full Text
- View/download PDF
21. Epidemiološke karakteristike hepatitis C virusne infekcije u Srbiji
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Delić, Dragan, Marković-Denić, Ljiljana, Simonović-Babić, Jasmina, Maksimović, Nataša, Katanić, Nataša, Mitrović, Nikola B., Delić, Dragan, Marković-Denić, Ljiljana, Simonović-Babić, Jasmina, Maksimović, Nataša, Katanić, Nataša, and Mitrović, Nikola B.
- Abstract
Hepatitis C virusna (HCV) infekcija predstavlja globalni zdravstveni problem..., Hepatitis C virus (HCV) infection represents global health issue...
- Published
- 2015
22. Krimska Kongo hemoragijska groznica: prikaz porodičnih epidemija
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Katanić, Radoslav, primary, Katanić, Nataša, additional, Mirić, Dijana, additional, Kisić, Bojana, additional, Bojović, Ksenija, additional, Odalović, Dragica, additional, and Odalović, Andrijana, additional
- Published
- 2013
- Full Text
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23. THERAPEUTIC APPROACH TO ACTINOMYCOSIS - EXPERIENCE GAINED AT THE DEPARTMENT OF INFECTIOUS AND TROPICAL DISEASES.
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KATANIĆ, Nataša, PAVLOVIĆ, Milorad, BOJOVIĆ, Ksenija, DULOVIĆ, Olga, GVOZDENOVIĆ, Eleonora, and SIMONOVIĆ, Jasmina
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- *
ACTINOMYCOSIS , *TROPICAL medicine , *COMMUNICABLE diseases , *PENICILLIN , *ANTIBACTERIAL agents , *GRAM-positive bacteria , *ANTIBIOTICS - Published
- 2011
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24. ANTIVIRAL TREATMENT OF HEPATITIS C IN SERBIAN PRISON SETTING: MEDICAL TREATMENT OUTCOMES AND PATIENTS' ADHERENCE.
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SIMONOVIĆ BABIĆ, Jasmina, BOJOVIĆ, Ksenija, DELIĆ, Dragan, KATANIĆ, Nataša, MITROVIĆ, Nikola, and MALINIĆ, Jovan
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THERAPEUTIC use of interferons , *RIBAVIRIN , *CHRONIC hepatitis C , *SEROPREVALENCE , *HEALTH outcome assessment , *VIRUS diseases , *PATIENTS , *THERAPEUTICS - Abstract
Introduction. Seroprevlence of chronic hepatitis C viral infection in correctional facilities ranges from 16% to 49%. However, there are only very limited data available on the course of hepatitis C viral infection and outcomes of treatment with pegylated interferon plus ribavirin in correctional settings. The aim of this study was to assess the feasibility and effectiveness of use of pegylated interferon plus ribavirin treatment in the Serbian correctional setting. Material and Methods. The study sample consisted of the patients with hepatitis C hospitalized in the Special Hospital for Prisoners in Belgrade (Serbia) during 2007-2013. Health authorities approved treatment for 32 patients out of 76 treatment-naive patients referred to this institution. The patients (N=32) received 180 mcg pegylated interferon alfa -2a once a week plus oral ribavirin in dosage of 800mg or 1000/1200 mg/day for 24 or 48-week treatment. All patients who completed therapy were assessed at the end of an additional 24-week treatment-free period for a sustained virological response. Results. Sustained virological response was achieved in 53.8% of hepatitis C viral infection genotype 1 patients and in 73.3% and 66.6% of patients with hepatitis C viral infection genotype 3 and 4, respectively. One patient with mixed genotype (1, 2) did not achieve sustained virological response. The overall safety profile of the treatment regimen was very good. The incidence of influenza-like symptoms and depression were low. A serious adverse event was recorded only in 6.4% of patients. Conclusion. The results showed that pegylated interferon alfa-2a plus ribavirin given once a week was well tolerated among prisoners and the regimen had the same adherence and effectiveness as in general population. [ABSTRACT FROM AUTHOR]
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- 2016
- Full Text
- View/download PDF
25. Impact of sustained virological response on the outcome and prognosis in patients with severe fibrosis and cirrhosis caused by chronic hepatitis C infection
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Jordović, Jelena, Delić, Dragan, Simonović-Babić, Jasmina, Bojović, Ksenija, and Katanić, Nataša
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hepatocelularni karcinom ,stabilan virusološki odgovor ,clinical outcome ,hepatocellular carcinoma ,sustained virological response ,kasni virusološki relaps ,late virological relapse ,klinički ishod - Abstract
Hepatitis C virus (HCV) je, globalno posmatrano, najčešći uzročnik hroničnog virusnog hepatitisa sa dugogodišnjim progresivnim tokom, varijabilnom kliničkom slikom i često nepredvidivim ishodom. Naša drţava spada u grupu zemalja sa intermedijernom zastupljenošću HCV infekcije, tj. prevalencijom od 0,19% meĎu dobrovoljnim davaocima krvi i procenjenom prevalencijom od 1,13% na nivou Srbije. U našoj zemlji postoji višedecenijsko iskustvo u dijagnostici i lečenju pacijenata sa HCV infekcijom, ali osim kliničkih opservacija, nema objavljenih podataka o dugoročnom ishodu kod ovih pacijenata. U terapijskom i prognostičkom smislu najzahtevniju grupu predstavljaju pacijenti kod kojih se HCV infekcija otkrije u fazi uznapredovalog oštećenja jetre (fibroze ili ciroze), najčešće zbog višedecenijskog asimptomatskog toka bolesti, ali i zbog neadekvatnih mera skrininga, posebno u populacijama pod povećanim rizikom. U ovoj grupi pacijenata, čak i nakon terapijskog uspeha i postizanja nedetektibilne viremije (bez obzira na vrstu korišćenog terapijskog protokola), postoji rizik od nastanka nepovoljnih ishoda-uključujući virusološki i biohemijski relaps, dekompenzaciju jetre i pojave hepatocelularnog karcinoma (HCC). Višedecenijsko iskustvo u primeni kombinovane antivirusne terapije pegilovanim interferonom (PEG-IFN) i ribavirinom je pokazalo da postizanje stabilnog virusološkog odgovora (SVR) značajno redukuje morbiditet i mortalitet u grupi pacijenata sa teškim preterapijskim oštećenjem jetre. Pored toga, kliničke opservacije i literaturni podaci stranih autora govore u prilog potrebi za nastavkom praćenja ove grupe pacijenata i redovnim skriningom na HCC, čak i u slučaju odrţavanja nedetektibilne viremije i/ili regresije fibroze. Multikauzalna priroda, individualan tok bolesti i često nepredvidiv dugoročni ishod u ovoj grupi pacijenata, čak i nakon trajne supresije viremije, a u odsustvu preporuka o duţini praćenja i bilo kakvih publikovanih podataka u našoj zemlji, predmet su posebnog interesovanja autora i ove studije... Hepatitis C virus (HCV) is the most common worldwide cause of chronic viral hepatitis with a long-term progression, variable clinical presentation and outcome. Serbia is a country with an intermediary prevalence of HCV infection, estimated around 0,19% among blood donors and aproximately 1,13% in the general population of Serbia. In spite of two decades of diagnostic and therapeutic experiences with clinical observances, there are no published data concerning long-term prognosis and outcome in these patients. Patients with baseline liver fibrosis and cirrhosis present the most challenging group of patients, and are mostly underdiagnosed due to the asymptomatic nature of the disease and insufficient screening, especially in certain groups of patients. In this particular group, even after treatment success and HCV supression, remains a risk of unfavourable outcomes including virological and biochemical relapse, adverse clinical outcomes and hepatocellular carcinoma (HCC). Although sustained virological response (SVR) undoubtedly reduces liver-related morbidity and mortality in patients with severe baseline liver damage, clinical observance and published data show that these patients need continuous monitoring and HCC screening in spite of HCV supression and/or fibrosis regression. AIM: Main purpose of this study was to examine reliability and durability of SVR, as a predictor of treatment success and long-term outcome in patients with HCV related severe baseline liver injury. PATIENTS AND METHODS: A cohort study included 325 patients with HCV related severe baseline liver injury, who completed treatment protocol with pegylated interferon and ribavirin from January 2003. until November 2011. at the Hepatology department of the Clinic for Infectious And Tropical Diseases, Clinical Center of Serbia. After treatment completion, patients were followed and endpoints were December 2015, death outcome or the date of the last checkup. Inclusion criteria included: chronic hepatitis C infection with elevated liver enzymes, age 18-65 years, baseline severe fibrosis or cirrhosis (METAVIR>F2), a completion of treatment protocol and informed consent...
- Published
- 2020
26. Komplikacije u toku varičele. Da li je vreme za vakcinu?
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Dulović, Olga, Gvozdenović, Eleonora, Nikolić, Jelena, Spurnić, Aleksandra Radovanović, Katanić, Nataša, and Kovačević-Pavićević, Dragana
- Subjects
- *
CHICKENPOX , *DISEASE risk factors , *DISEASE complications , *VARICELLA-zoster virus , *VIRAL pneumonia , *RESPIRATORY infections - Abstract
Background/Aim. Varicella is a common and benign disease of childhood. Complications are rare, but in some patients, even without risk factors, severe, life treathening complications could be seen. The aim of this study was to establish the type and frequency of varicella complications among hospitalised patients over an 8-year period. Methods. This retrospective analysis included medical charts of the patients hospitalised in the Infectious Disease Clinic, Belgrade, Serbia, from 2001-2008 (4.85% of all registered patients with varicella in Belgrade, 2001-2008). Among hospitalised patients dermografic characteristics were analysed: hospitalisation lenght, presence and type of complications, presence of immunocompromising conditions and outcome of the disease. The diagnosis of varicella was made on clinical grounds, and in persons > 40 years, with negative epidemiological data of contacts, serological confirmation (ELISA VZV IgM/IgG BioRad®) and avidity of IgG antibodies were done to exclude the possibility of disseminated herpes zoster. Results. A total of 474 patient were hospitalised over an 8-year period. The age of patients was from 5 months to 75 years (mean 22.4 ± 16.1, median 23.5 years). The majority of patients were adults (n = 279; 58.9%) and 195 (41.1%) patients were ≤ 15 years old. Complications were found in 321/474 (67.7%) patients. The registered complications were: varicella pneumonia (n = 198; 41.38%), bacterial skin infections (n = 40; 8.4%), cerebelitis (n = 28; 5.9%), bacterial respiratory infection (n = 21; 4.4%), viral meningitis (n = 10; 2.31%), encephalitis (n = 9; 1.9%), thrombocytopenia (n = 2; 0.4%); 11 (2.3%) patients had more than one complication, among them were sepsis, myopericarditis and retinal hemorrhages. When complications were analysed according to the age, there were no statistical significance, but when type of complication was analysed statistical significance was found (p < 0.05). In adults, pneumonia was the most common complication: 173/279 (62%), followed by skin infections (2.9%), bacterial respiratory infections (2,2%), and more than one complication (2.3%). Pneumonia was more common in adults than in children (7 : 1). In children skin infections were the most common complications (16.4%), followed by cerebelitis (13.3%), viral pneumonia (12.8%), bacterial respiratory infections (7.7%), encephalitis (3.6%), and more than one complication (4.1%). Neuroinfections were more common in children than in adults (6:1), as well as bacterial skin infections (4 : 1). Two patients died (0,4%). Conclusion. There was no difference in the incidence of varicella complication in children and adults, but the type of complication differed. In children the most common complications were skin and neurological infections, while in adults it was varicella pneumonia. These data provide a baseline for estimating the burden of varicella in Belgrade and support the inclusion of varicella vaccine in childhood immunisation program in Serbia. [ABSTRACT FROM AUTHOR]
- Published
- 2010
27. Ispitivanje efikasnosti peroralno primenjenog teikoplanina u farmakoterapiji teških, komplikovanih i refraktarnih oblika Clostridium difficile infekcije
- Author
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Popović, Nataša A., Korać, Miloš, Nešić, Zorica, Gojković-Bukarica, Ljiljana, Milošević, Ivana, and Katanić, Nataša
- Subjects
teicoplanin ,recurrence ,severe disease ,teikoplanin ,refrakratna Clostridium difficile infekcija ,teška forma bolesti ,recidiv ,Clostridium difficile ,refractory Clostridium difficile infection - Abstract
Clostridium difficile je najčešći uzročnik postantibiotske dijareje i pseudomembranoznog kolitisa. Nekada sporadična infekcija, poslednjih petnaest godina dobija razmere globalne epidemije i postaje jedna od vodećih intrahospitalnih infekcija u svetu i značajan uzrok smrti naročito među starijima od 65 godina. Porast broja obolelih, kao i sve veći broj bolesnika sa teškom kliničkom slikom i komplikacijama te sve češća pojava recidiva i slučajeva refraktarnih na standardnu terapiju vezuju se za razvoj hipervirulentnog soja bakterije, NAP1/BI/027. Spektar kliničkih oblika C. difficile infekcije obuhvata blagu do umerenu bolest u vidu dijareje bez kolitisa, tešku i tešku komplikovanu formu koja se karakteriše pojavom ileusa, toksičnog megakolona, hipotenzije sa primenom vazopresora, organskom disfunkcijom, izmenjenim mentalnim statusom, leukocitozom ≥ 35000/mm3 ili leukopenijom < 2000/mm3. Glavni problem u svakodnevnom kliničkom radu sa obolelima od C. difficle infekcije predstavlja velika učestalost recidiva bolesti, kao i sve češća pojava refraktarnih slučajeva. Standardnu terapiju C. difficile infekcije čine metronidazol i vankomicin, a poslednjih godina i fidaksomicin, čijim primenom je samo delimično smanjen rizik od recidiva. U ranije sprovedenim istraživanjima o primeni teikoplanina u lečenju C. difficile infekcije teikoplanin se pokazao kao uspešan, međutim, ova istraživanja su sprovedena u vreme pre pojave hipervirulentnog soja i „epidemije“ C. difficile infekcije i obuhvatala su mali broj ispitanika. CILJ: Cilj ovog istraživanja bio je da se ispita i uporedi ishod C. difficile infekcije kod bolesnika sa teškom formom bolesti lečenih teikoplaninom i vankomicinom u pogledu postignutog procenta kliničkog izlečenja, vremena od početka terapije do prestanka proliva, smrtnosti kao i učestalosti recidiva nakon 8 nedelja praćenja. Drugi cilj je bio da se utvrdi efikasnost peroralno primenjenog teikoplanina (u pogledu kliničkog izlečenja, smrtnosti, vremena od početka primene teikoplanina do prestanka proliva i učestalosti recidiva) u lečenju bolesnika kod kojih je nakon 10-14 dana standardne terapije izostalo kliničko izlečenje...
- Published
- 2018
28. Epidemiological characteristics of hepatitis C virus infection in Serbia
- Author
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Mitrović, Nikola B., Delić, Dragan, Marković-Denić, Ljiljana, Simonović-Babić, Jasmina, Maksimović, Nataša, and Katanić, Nataša
- Subjects
prevalence ,faktori rizika ,voluntary blood donors ,virus diseases ,dobrovoljni davaoci krvi ,Srbija ,risk factors ,Hepatitis C ,prevalencija ,Serbia ,digestive system diseases - Abstract
Hepatitis C virusna (HCV) infekcija predstavlja globalni zdravstveni problem... Hepatitis C virus (HCV) infection represents global health issue...
- Published
- 2015
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