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5. EP06.28: Prenatal diagnosis and outcome of meso/dextrocardio: a single‐centre report of 29 cases.

Author

Tanaka, Y., Kasuga, Y., Kajikawa, K., Takahashi, M., Akita, K., Fukuma, Y., Tamai, J., Ohtani, T., Ikenoue, S., and Tanaka, M.

Subjects
*VENA cava superior, *ESOPHAGEAL fistula, *PULMONARY hypoplasia, *DEXTROCARDIA, *DIAPHRAGMATIC hernia, PULMONARY atresia, ESOPHAGEAL atresia
Abstract

This article discusses the prenatal diagnosis and outcomes of meso/dextrocardia, a cardiac axis abnormality. The study reviewed 29 cases of fetal meso/dextrocardia diagnosed in a single hospital between January 2014 and February 2024. The results showed that there were eight cases of mesocardia and 21 cases of dextrocardia, with different complications associated with each. The study emphasizes the importance of evaluating the entire fetal body for anomalies when meso/dextrocardia is detected. [Extracted from the article]

Published
2024
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8. Language vs. individuals in cross-linguistic corpus typology

Author

Haig, G., Schnell, S., Barth, D., Evans, N., Arka, I. W., Bergqvist, H., Forker, D., Gipper, S., Hodge, G., Kashima, E., Kasuga, Y., Kawakami, C., Kimoto, Y., Knuchel, D., Kogura, N., Kurabe, K., Mansfield, J., Narrog, H., Pratiwi, D. P. E., Putten, S. van, Senge, C., Tykhostup, O., Haig, G., Schnell, S., Barth, D., Evans, N., Arka, I. W., Bergqvist, H., Forker, D., Gipper, S., Hodge, G., Kashima, E., Kasuga, Y., Kawakami, C., Kimoto, Y., Knuchel, D., Kogura, N., Kurabe, K., Mansfield, J., Narrog, H., Pratiwi, D. P. E., Putten, S. van, Senge, C., and Tykhostup, O.

Abstract

Contains fulltext : 286116.pdf (Publisher’s version ) (Open Access)

Published
2021

9. Language vs. individuals in cross-linguistic corpus typology

Author

Barth, D., Evans, N., Arka, I. W., Bergqvist, H., Forker, D., Gipper, S., Hodge, G., Kashima, E., Kasuga, Y., Kawakami, C., Kimoto, Y., Knuchel, D., Kogura, N., Kurabe, K., Mansfield, J., Narrog, H., Pratiwi, D. P. E., Putten, S. van, Senge, C., Tykhostup, O., Haig, G., and Schnell, S.

Subjects
Language documentation and conservation special publication
Published
2021

11. Identification of novel breast cancer susceptibility loci in meta-analyses conducted among Asian and European descendants.

Author

John E.M., Shu X., Long J., Cai Q., Kweon S.-S., Choi J.-Y., Kubo M., Park S.K., Bolla M.K., Dennis J., Wang Q., Yang Y., Shi J., Guo X., Li B., Tao R., Aronson K.J., Chan K.Y.K., Chan T.L., Gao Y.-T., Hartman M., Kee Ho W., Ito H., Iwasaki M., Iwata H., Kasuga Y., Soon Khoo U., Kim M.-K., Kong S.-Y., Kurian A.W., Kwong A., Lee E.-S., Li J., Lophatananon A., Low S.-K., Mariapun S., Matsuda K., Matsuo K., Muir K., Noh D.-Y., Park B., Park M.-H., Shen C.-Y., Shin M.-H., Spinelli J.J., Takahashi A., Tseng C., Tsugane S., Wu A.H., Xiang Y.-B., Yamaji T., Zheng Y., Milne R.L., Dunning A.M., Pharoah P.D.P., Garcia-Closas M., Teo S.-H., Shu X.-O., Kang D., Easton D.F., Simard J., Zheng W., John E.M., Shu X., Long J., Cai Q., Kweon S.-S., Choi J.-Y., Kubo M., Park S.K., Bolla M.K., Dennis J., Wang Q., Yang Y., Shi J., Guo X., Li B., Tao R., Aronson K.J., Chan K.Y.K., Chan T.L., Gao Y.-T., Hartman M., Kee Ho W., Ito H., Iwasaki M., Iwata H., Kasuga Y., Soon Khoo U., Kim M.-K., Kong S.-Y., Kurian A.W., Kwong A., Lee E.-S., Li J., Lophatananon A., Low S.-K., Mariapun S., Matsuda K., Matsuo K., Muir K., Noh D.-Y., Park B., Park M.-H., Shen C.-Y., Shin M.-H., Spinelli J.J., Takahashi A., Tseng C., Tsugane S., Wu A.H., Xiang Y.-B., Yamaji T., Zheng Y., Milne R.L., Dunning A.M., Pharoah P.D.P., Garcia-Closas M., Teo S.-H., Shu X.-O., Kang D., Easton D.F., Simard J., and Zheng W.

Abstract

Known risk variants explain only a small proportion of breast cancer heritability, particularly in Asian women. To search for additional genetic susceptibility loci for breast cancer, here we perform a meta-analysis of data from genome-wide association studies (GWAS) conducted in Asians (24,206 cases and 24,775 controls) and European descendants (122,977 cases and 105,974 controls). We identified 31 potential novel loci with the lead variant showing an association with breast cancer risk at P < 5 x 10-8. The associations for 10 of these loci were replicated in an independent sample of 16,787 cases and 16,680 controls of Asian women (P < 0.05). In addition, we replicated the associations for 78 of the 166 known risk variants at P < 0.05 in Asians. These findings improve our understanding of breast cancer genetics and etiology and extend previous findings from studies of European descendants to Asian women.Copyright © 2020, The Author(s).

Published
2020

12. Identification of novel breast cancer susceptibility loci in meta-analyses conducted among Asian and European descendants

Author

Shu, X, Long, J, Cai, Q, Kweon, S-S, Choi, J-Y, Kubo, M, Park, SK, Bolla, MK, Dennis, J, Wang, Q, Yang, Y, Shi, J, Guo, X, Li, B, Tao, R, Aronson, KJ, Chan, KYK, Chan, TL, Gao, Y-T, Hartman, M, Ho, WK, Ito, H, Iwasaki, M, Iwata, H, John, EM, Kasuga, Y, Khoo, US, Kim, M-K, Kong, S-Y, Kurian, AW, Kwong, A, Lee, E-S, Li, J, Lophatananon, A, Low, S-K, Mariapun, S, Matsuda, K, Matsuo, K, Muir, K, Noh, D-Y, Park, B, Park, M-H, Shen, C-Y, Shin, M-H, Spinelli, JJ, Takahashi, A, Tseng, C, Tsugane, S, Wu, AH, Xiang, Y-B, Yamaji, T, Zheng, Y, Milne, RL, Dunning, AM, Pharoah, PDP, Garcia-Closas, M, Teo, S-H, Shu, X-O, Kang, D, Easton, DF, Simard, J, Zheng, W, Shu, X, Long, J, Cai, Q, Kweon, S-S, Choi, J-Y, Kubo, M, Park, SK, Bolla, MK, Dennis, J, Wang, Q, Yang, Y, Shi, J, Guo, X, Li, B, Tao, R, Aronson, KJ, Chan, KYK, Chan, TL, Gao, Y-T, Hartman, M, Ho, WK, Ito, H, Iwasaki, M, Iwata, H, John, EM, Kasuga, Y, Khoo, US, Kim, M-K, Kong, S-Y, Kurian, AW, Kwong, A, Lee, E-S, Li, J, Lophatananon, A, Low, S-K, Mariapun, S, Matsuda, K, Matsuo, K, Muir, K, Noh, D-Y, Park, B, Park, M-H, Shen, C-Y, Shin, M-H, Spinelli, JJ, Takahashi, A, Tseng, C, Tsugane, S, Wu, AH, Xiang, Y-B, Yamaji, T, Zheng, Y, Milne, RL, Dunning, AM, Pharoah, PDP, Garcia-Closas, M, Teo, S-H, Shu, X-O, Kang, D, Easton, DF, Simard, J, and Zheng, W

Abstract

Known risk variants explain only a small proportion of breast cancer heritability, particularly in Asian women. To search for additional genetic susceptibility loci for breast cancer, here we perform a meta-analysis of data from genome-wide association studies (GWAS) conducted in Asians (24,206 cases and 24,775 controls) and European descendants (122,977 cases and 105,974 controls). We identified 31 potential novel loci with the lead variant showing an association with breast cancer risk at P < 5 × 10-8. The associations for 10 of these loci were replicated in an independent sample of 16,787 cases and 16,680 controls of Asian women (P < 0.05). In addition, we replicated the associations for 78 of the 166 known risk variants at P < 0.05 in Asians. These findings improve our understanding of breast cancer genetics and etiology and extend previous findings from studies of European descendants to Asian women.

Published
2020

23. Differences in fetal fractional limb volume changes in normal and gestational diabetic pregnancies: an exploratory observational study.

Author

Akiba, Y, Ikenoue, S, Endo, T, Kasuga, Y, Ochiai, D, Miyakoshi, K, Ishii, R, Yakubo, K, and Tanaka, M

Subjects
FETAL tissues, PREGNANT women, SCIENTIFIC observation, GESTATIONAL diabetes, JAPANESE women, BONE shafts, ANTHROPOMETRY, THIGH, FETAL development, GESTATIONAL age, ARM, HUMERUS, RESEARCH funding, FEMUR, FETAL ultrasonic imaging
Abstract

Objective: Fetal fractional limb volume has been proposed as a useful measure for quantifying fetal soft tissue development. The aim of this study was to investigate the growth of fractional arm volume (AVol) and fractional thigh volume (TVol) of fetuses with maternal gestational diabetes (GDM) compared with those of fetuses with normal glucose tolerance (NGT). We hypothesised fetal fractional limb volume would be larger in the GDM group than in the NGT group in late gestation.Design: Exploratory observational study.Setting: Saitama Municipal Hospital.Sample: A total of 165 (125 NGT and 40 GDM) singleton Japanese pregnant women.Methods: AVol and TVol were assessed between 20 and 37 weeks' gestation as cylindrical limb volumes based on 50% of the fetal humeral or femoral diaphysis length. Women were diagnosed as GDM based on the criteria of the Japan Society of Obstetrics and Gynecology.Main Outcome Measures: AVol and TVol were compared between women with NGT and those with GDM at each gestational age period (2-week intervals from 20 to 37 weeks' gestation).Results: Overall, 287 ultrasound scans were performed (NGT group, 205 scans; GDM group, 82 scans). There was no significant difference of AVol between the groups before 32 weeks' gestation. AVol was significantly larger in the GDM group than in the NGT group after 32 weeks' gestation (P < 0.05). TVol was not statistically different between the groups across gestation.Conclusions: Detection of variations in fetal AVol may provide greater insight into understanding the origins of altered fetal body proportion in GDM.Tweetable Abstract: AVol, but not TVol, is significantly larger in fetuses with GDM than in those with NGT after 32 weeks' gestation. [ABSTRACT FROM AUTHOR]

Published
2021
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31. Thoracic duct cyst in supraclavicular region

Author

Maruyama, M., Kobayashi, S., Kasuga, Y., Fujimori, M., Yokoyama, S., Shingu, K., Hama, Y., Ito, K., Kato, R., and Amano, J.

Subjects
Adult, Mediastinal Cyst, parasitic diseases, Humans, Female, Neck, Research Article
Abstract

A 28-year-old female attended an outpatient clinic in October, 1989, because of a tumor in the left supraclavicular fossa, detected in a health examination. Following exploratory puncture of the tumor which yielded milky-white fluid, suggesting a cyst in the thoracic duct, she was admitted to our department. The cyst was unilocular measuring about 6 cm in diameter, and the fluid content was chyle-rich in lipids. Lymphography demonstrated a lymphatic structure adjacent to the lesion and scattered lymph vessels on the cyst surface. On November 16 the cyst was resected. A restiform structure was observed between the cyst and the thoracic duct, but the presence or absence of communication was unclear. The histological diagnosis was thoracic duct cyst. Thoracic duct cyst occurring in the cervical region is very rare. Our case may provide useful information as to its pathogenesis and the mode of retention of cyst fluid. Images Fig 1 Fig 2 Fig 3

Published
1997

33. Cytophagic Histiocytic Panniculitis Evolving Into Total Lipodystrophy

Author

Takao Saruta, Yanagawa T, Hiroshi Maruyama, Noya K, Kataoka K, Kasuga Y, Takei I, Kawamura S, Toyama K, and Yokoyama A

Subjects
Male, Pathology, medicine.medical_specialty, Panniculitis, Time Factors, Adolescent, Lipodystrophy, Biopsy, Prednisolone, Cytophagic histiocytic panniculitis, Adipose tissue, Body weight, Total Lipodystrophy, Diabetes Complications, chemistry.chemical_compound, Lactate dehydrogenase, Diabetes Mellitus, medicine, Humans, Insulin, Coagulation Disorder, Skin, Severe neutropenia, business.industry, General Medicine, medicine.anatomical_structure, chemistry, Bone marrow, business, Histiocytosis
Abstract

A 15-year-old boy had persistent fever with severe neutropenia, thrombocytopenia, coagulation disorder, and marked elevation of lactate dehydrogenase values. A diagnosis of cytophagic histiocytic panniculitis was made after repeated skin biopsies. Three years after onset, he gradually lost 20 kg in body weight, and both skin and bone marrow specimens revealed degenerative changes of fatty tissue without any inflammatory cells. These findings suggest that total lipodystrophy syndrome results from the inflammatory destructive process of adipose tissue. To our knowledge, our report is the first to show, in a series of histologic studies, that an inflammatory destructive process may be involved in some cases of total lipodystrophy syndrome.

Published
1990

37. Genome-wide association study identifies breast cancer risk variant at 10q21.2: results from the Asia Breast Cancer Consortium

Author

Cai, Q., primary, Long, J., additional, Lu, W., additional, Qu, S., additional, Wen, W., additional, Kang, D., additional, Lee, J.-Y., additional, Chen, K., additional, Shen, H., additional, Shen, C.-Y., additional, Sung, H., additional, Matsuo, K., additional, Haiman, C. A., additional, Khoo, U. S., additional, Ren, Z., additional, Iwasaki, M., additional, Gu, K., additional, Xiang, Y.-B., additional, Choi, J.-Y., additional, Park, S. K., additional, Zhang, L., additional, Hu, Z., additional, Wu, P.-E., additional, Noh, D.-Y., additional, Tajima, K., additional, Henderson, B. E., additional, Chan, K. Y. K., additional, Su, F., additional, Kasuga, Y., additional, Wang, W., additional, Cheng, J.-R., additional, Yoo, K.-Y., additional, Zheng, H., additional, Liu, Y., additional, Shieh, Y.-L., additional, Kim, S.-W., additional, Lee, J. W., additional, Iwata, H., additional, Le Marchand, L., additional, Chan, S. Y., additional, Xie, X., additional, Tsugane, S., additional, Lee, M. H., additional, Wang, S., additional, Li, G., additional, Levy, S., additional, Huang, B., additional, Shi, J., additional, Delahanty, R., additional, Zheng, Y., additional, Li, C., additional, Gao, Y.-T., additional, Shu, X.-O., additional, and Zheng, W., additional

Published
2011
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42. EP34.11: Sonographic prediction of placental invasion and perioperative intervention in placenta previa using the placenta accreta index.

Author

Hasegawa, K., Ikenoue, S., Takeda, M., Tanaka, Y., Tamai, J., Hamuro, A., Tamagawa, M., Kasuga, Y., Ochiai, D., and Tanaka, M.

Abstract

Placenta accreta was diagnosed histologically after hysterectomy, or clinically defined as a retained placenta after manual placenta removal. Placenta accreta spectrum is associated with perinatal complications including maternal mortality. [Extracted from the article]

Published
2022
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