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5. Identification of novel breast cancer susceptibility loci in meta-analyses conducted among Asian and European descendants

Author

Shu, Xiang, Long, Jirong, Cai, Qiuyin, Kweon, Sun-Seog, Choi, Ji-Yeob, Kubo, Michiaki, Park, Sue K., Bolla, Manjeet K., Dennis, Joe, Wang, Qin, Yang, Yaohua, Shi, Jiajun, Guo, Xingyi, Li, Bingshan, Tao, Ran, Aronson, Kristan J., Chan, Kelvin Y. K., Chan, Tsun L., Gao, Yu-Tang, Hartman, Mikael, Kee Ho, Weang, Ito, Hidemi, Iwasaki, Motoki, Iwata, Hiroji, John, Esther M., Kasuga, Yoshio, Soon Khoo, Ui, Kim, Mi-Kyung, Kong, Sun-Young, Kurian, Allison W., Kwong, Ava, Lee, Eun-Sook, Li, Jingmei, Lophatananon, Artitaya, Low, Siew-Kee, Mariapun, Shivaani, Matsuda, Koichi, Matsuo, Keitaro, Muir, Kenneth, Noh, Dong-Young, Park, Boyoung, Park, Min-Ho, Shen, Chen-Yang, Shin, Min-Ho, Spinelli, John J., Takahashi, Atsushi, Tseng, Chiuchen, Tsugane, Shoichiro, Wu, Anna H., Xiang, Yong-Bing, Yamaji, Taiki, Zheng, Ying, Milne, Roger L., Dunning, Alison M., Pharoah, Paul D. P., García-Closas, Montserrat, Teo, Soo-Hwang, Shu, Xiao-ou, Kang, Daehee, Easton, Douglas F., Simard, Jacques, and Zheng, Wei

Published
2020
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6. Data from Pathway Analyses Identify TGFBR2 as Potential Breast Cancer Susceptibility Gene: Results from a Consortium Study among Asians

Author

Ma, Xiangyu, primary, Beeghly-Fadiel, Alicia, primary, Lu, Wei, primary, Shi, Jiajun, primary, Xiang, Yong-Bing, primary, Cai, Qiuyin, primary, Shen, Hongbing, primary, Shen, Chen-Yang, primary, Ren, Zefang, primary, Matsuo, Keitaro, primary, Khoo, Ui Soon, primary, Iwasaki, Motoki, primary, Long, Jirong, primary, Zhang, Ben, primary, Ji, Bu-Tian, primary, Zheng, Ying, primary, Wang, Wenjing, primary, Hu, Zhibin, primary, Liu, Yao, primary, Wu, Pei-Ei, primary, Shieh, Ya-Lan, primary, Wang, Shenming, primary, Xie, Xiaoming, primary, Ito, Hidemi, primary, Kasuga, Yoshio, primary, Chan, Kelvin Y.K., primary, Iwata, Hiroji, primary, Tsugane, Shoichiro, primary, Gao, Yu-Tang, primary, Shu, Xiao Ou, primary, Moses, Harold L., primary, and Zheng, Wei, primary

Published
2023
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7. Supplementary Tables 1 - 3 from Pathway Analyses Identify TGFBR2 as Potential Breast Cancer Susceptibility Gene: Results from a Consortium Study among Asians

Author

Ma, Xiangyu, primary, Beeghly-Fadiel, Alicia, primary, Lu, Wei, primary, Shi, Jiajun, primary, Xiang, Yong-Bing, primary, Cai, Qiuyin, primary, Shen, Hongbing, primary, Shen, Chen-Yang, primary, Ren, Zefang, primary, Matsuo, Keitaro, primary, Khoo, Ui Soon, primary, Iwasaki, Motoki, primary, Long, Jirong, primary, Zhang, Ben, primary, Ji, Bu-Tian, primary, Zheng, Ying, primary, Wang, Wenjing, primary, Hu, Zhibin, primary, Liu, Yao, primary, Wu, Pei-Ei, primary, Shieh, Ya-Lan, primary, Wang, Shenming, primary, Xie, Xiaoming, primary, Ito, Hidemi, primary, Kasuga, Yoshio, primary, Chan, Kelvin Y.K., primary, Iwata, Hiroji, primary, Tsugane, Shoichiro, primary, Gao, Yu-Tang, primary, Shu, Xiao Ou, primary, Moses, Harold L., primary, and Zheng, Wei, primary

Published
2023
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8. Data from Replication and Functional Genomic Analyses of the Breast Cancer Susceptibility Locus at 6q25.1 Generalize Its Importance in Women of Chinese, Japanese, and European Ancestry

Author

Cai, Qiuyin, primary, Wen, Wanqing, primary, Qu, Shimian, primary, Li, Guoliang, primary, Egan, Kathleen M., primary, Chen, Kexin, primary, Deming, Sandra L., primary, Shen, Hongbing, primary, Shen, Chen-Yang, primary, Gammon, Marilie D., primary, Blot, William J., primary, Matsuo, Keitaro, primary, Haiman, Christopher A., primary, Khoo, Ui Soon, primary, Iwasaki, Motoki, primary, Santella, Regina M., primary, Zhang, Lina, primary, Fair, Alecia Malin, primary, Hu, Zhibin, primary, Wu, Pei-Ei, primary, Signorello, Lisa B., primary, Titus-Ernstoff, Linda, primary, Tajima, Kazuo, primary, Henderson, Brian E., primary, Chan, Kelvin Y.K., primary, Kasuga, Yoshio, primary, Newcomb, Polly A., primary, Zheng, Hong, primary, Cui, Yong, primary, Wang, Furu, primary, Shieh, Ya-Lan, primary, Iwata, Hiroji, primary, Le Marchand, Loic, primary, Chan, Sum Yin, primary, Shrubsole, Martha J., primary, Trentham-Dietz, Amy, primary, Tsugane, Shoichiro, primary, Garcia-Closas, Montserrat, primary, Long, Jirong, primary, Li, Chun, primary, Shi, Jiajun, primary, Huang, Bo, primary, Xiang, Yong-Bing, primary, Gao, Yu-Tang, primary, Lu, Wei, primary, Shu, Xiao-Ou, primary, and Zheng, Wei, primary

Published
2023
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9. Supplementary Methods and Materials from Replication and Functional Genomic Analyses of the Breast Cancer Susceptibility Locus at 6q25.1 Generalize Its Importance in Women of Chinese, Japanese, and European Ancestry

Author

Cai, Qiuyin, primary, Wen, Wanqing, primary, Qu, Shimian, primary, Li, Guoliang, primary, Egan, Kathleen M., primary, Chen, Kexin, primary, Deming, Sandra L., primary, Shen, Hongbing, primary, Shen, Chen-Yang, primary, Gammon, Marilie D., primary, Blot, William J., primary, Matsuo, Keitaro, primary, Haiman, Christopher A., primary, Khoo, Ui Soon, primary, Iwasaki, Motoki, primary, Santella, Regina M., primary, Zhang, Lina, primary, Fair, Alecia Malin, primary, Hu, Zhibin, primary, Wu, Pei-Ei, primary, Signorello, Lisa B., primary, Titus-Ernstoff, Linda, primary, Tajima, Kazuo, primary, Henderson, Brian E., primary, Chan, Kelvin Y.K., primary, Kasuga, Yoshio, primary, Newcomb, Polly A., primary, Zheng, Hong, primary, Cui, Yong, primary, Wang, Furu, primary, Shieh, Ya-Lan, primary, Iwata, Hiroji, primary, Le Marchand, Loic, primary, Chan, Sum Yin, primary, Shrubsole, Martha J., primary, Trentham-Dietz, Amy, primary, Tsugane, Shoichiro, primary, Garcia-Closas, Montserrat, primary, Long, Jirong, primary, Li, Chun, primary, Shi, Jiajun, primary, Huang, Bo, primary, Xiang, Yong-Bing, primary, Gao, Yu-Tang, primary, Lu, Wei, primary, Shu, Xiao-Ou, primary, and Zheng, Wei, primary

Published
2023
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13. Genome- and transcriptome-wide association studies of 386,000 Asian and European-ancestry women provide new insights into breast cancer genetics

Author

Jia, Guochong, primary, Ping, Jie, additional, Shu, Xiang, additional, Yang, Yaohua, additional, Cai, Qiuyin, additional, Kweon, Sun-Seog, additional, Choi, Ji-Yeob, additional, Kubo, Michiaki, additional, Park, Sue K., additional, Bolla, Manjeet K., additional, Dennis, Joe, additional, Wang, Qin, additional, Guo, Xingyi, additional, Li, Bingshan, additional, Tao, Ran, additional, Aronson, Kristan J., additional, Chan, Tsun L., additional, Gao, Yu-Tang, additional, Hartman, Mikael, additional, Ho, Weang Kee, additional, Ito, Hidemi, additional, Iwasaki, Motoki, additional, Iwata, Hiroji, additional, John, Esther M., additional, Kasuga, Yoshio, additional, Kim, Mi-Kyung, additional, Kurian, Allison W., additional, Kwong, Ava, additional, Li, Jingmei, additional, Lophatananon, Artitaya, additional, Low, Siew-Kee, additional, Mariapun, Shivaani, additional, Matsuda, Koichi, additional, Matsuo, Keitaro, additional, Muir, Kenneth, additional, Noh, Dong-Young, additional, Park, Boyoung, additional, Park, Min-Ho, additional, Shen, Chen-Yang, additional, Shin, Min-Ho, additional, Spinelli, John J., additional, Takahashi, Atsushi, additional, Tseng, Chiuchen, additional, Tsugane, Shoichiro, additional, Wu, Anna H., additional, Yamaji, Taiki, additional, Zheng, Ying, additional, Dunning, Alison M., additional, Pharoah, Paul D.P., additional, Teo, Soo-Hwang, additional, Kang, Daehee, additional, Easton, Douglas F., additional, Simard, Jacques, additional, Shu, Xiao-ou, additional, Long, Jirong, additional, and Zheng, Wei, additional

Published
2022
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14. Association analysis identifies 65 new breast cancer risk loci

Author

Michailidou, Kyriaki, Lindström, Sara, Dennis, Joe, Beesley, Jonathan, Hui, Shirley, Kar, Siddhartha, Lemaçon, Audrey, Soucy, Penny, Glubb, Dylan, Rostamianfar, Asha, Bolla, Manjeet K., Wang, Qin, Tyrer, Jonathan, Dicks, Ed, Lee, Andrew, Wang, Zhaoming, Allen, Jamie, Keeman, Renske, Eilber, Ursula, French, Juliet D., Qing Chen, Xiao, Fachal, Laura, McCue, Karen, McCart Reed, Amy E., Ghoussaini, Maya, Carroll, Jason S., Jiang, Xia, Finucane, Hilary, Adams, Marcia, Adank, Muriel A., Ahsan, Habibul, Aittomäki, Kristiina, Anton-Culver, Hoda, Antonenkova, Natalia N., Arndt, Volker, Aronson, Kristan J., Arun, Banu, Auer, Paul L., Bacot, François, Barrdahl, Myrto, Baynes, Caroline, Beckmann, Matthias W., Behrens, Sabine, Benitez, Javier, Bermisheva, Marina, Bernstein, Leslie, Blomqvist, Carl, Bogdanova, Natalia V., Bojesen, Stig E., Bonanni, Bernardo, Børresen-Dale, Anne-Lise, Brand, Judith S., Brauch, Hiltrud, Brennan, Paul, Brenner, Hermann, Brinton, Louise, Broberg, Per, Brock, Ian W., Broeks, Annegien, Brooks-Wilson, Angela, Brucker, Sara Y., Brüning, Thomas, Burwinkel, Barbara, Butterbach, Katja, Cai, Qiuyin, Cai, Hui, Caldés, Trinidad, Canzian, Federico, Carracedo, Angel, Carter, Brian D., Castelao, Jose E., Chan, Tsun L., David Cheng, Ting-Yuan, Seng Chia, Kee, Choi, Ji-Yeob, Christiansen, Hans, Clarke, Christine L., Collée, Margriet, Conroy, Don M., Cordina-Duverger, Emilie, Cornelissen, Sten, Cox, David G., Cox, Angela, Cross, Simon S., Cunningham, Julie M., Czene, Kamila, Daly, Mary B., Devilee, Peter, Doheny, Kimberly F., Dörk, Thilo, dos-Santos-Silva, Isabel, Dumont, Martine, Durcan, Lorraine, Dwek, Miriam, Eccles, Diana M., Ekici, Arif B., Eliassen, A. Heather, Ellberg, Carolina, Elvira, Mingajeva, Engel, Christoph, Eriksson, Mikael, Fasching, Peter A., Figueroa, Jonine, Flesch-Janys, Dieter, Fletcher, Olivia, Flyger, Henrik, Fritschi, Lin, Gaborieau, Valerie, Gabrielson, Marike, Gago-Dominguez, Manuela, Gao, Yu-Tang, Gapstur, Susan M., García-Sáenz, José A., Gaudet, Mia M., Georgoulias, Vassilios, Giles, Graham G., Glendon, Gord, Goldberg, Mark S., Goldgar, David E., González-Neira, Anna, Grenaker Alnæs, Grethe I., Grip, Mervi, Gronwald, Jacek, Grundy, Anne, Guénel, Pascal, Haeberle, Lothar, Hahnen, Eric, Haiman, Christopher A., Håkansson, Niclas, Hamann, Ute, Hamel, Nathalie, Hankinson, Susan, Harrington, Patricia, Hart, Steven N., Hartikainen, Jaana M., Hartman, Mikael, Hein, Alexander, Heyworth, Jane, Hicks, Belynda, Hillemanns, Peter, Ho, Dona N., Hollestelle, Antoinette, Hooning, Maartje J., Hoover, Robert N., Hopper, John L., Hou, Ming-Feng, Hsiung, Chia-Ni, Huang, Guanmengqian, Humphreys, Keith, Ishiguro, Junko, Ito, Hidemi, Iwasaki, Motoki, Iwata, Hiroji, Jakubowska, Anna, Janni, Wolfgang, John, Esther M., Johnson, Nichola, Jones, Kristine, Jones, Michael, Jukkola-Vuorinen, Arja, Kaaks, Rudolf, Kabisch, Maria, Kaczmarek, Katarzyna, Kang, Daehee, Kasuga, Yoshio, Kerin, Michael J., Khan, Sofia, Khusnutdinova, Elza, Kiiski, Johanna I., Kim, Sung-Won, Knight, Julia A., Kosma, Veli-Matti, Kristensen, Vessela N., Krüger, Ute, Kwong, Ava, Lambrechts, Diether, Le Marchand, Loic, Lee, Eunjung, Lee, Min Hyuk, Lee, Jong Won, Neng Lee, Chuen, Lejbkowicz, Flavio, Li, Jingmei, Lilyquist, Jenna, Lindblom, Annika, Lissowska, Jolanta, Lo, Wing-Yee, Loibl, Sibylle, Long, Jirong, Lophatananon, Artitaya, Lubinski, Jan, Luccarini, Craig, Lux, Michael P., Ma, Edmond S. K., MacInnis, Robert J., Maishman, Tom, Makalic, Enes, Malone, Kathleen E., Kostovska, Ivana Maleva, Mannermaa, Arto, Manoukian, Siranoush, Manson, JoAnn E., Margolin, Sara, Mariapun, Shivaani, Martinez, Maria Elena, Matsuo, Keitaro, Mavroudis, Dimitrios, McKay, James, McLean, Catriona, Meijers-Heijboer, Hanne, Meindl, Alfons, Menéndez, Primitiva, Menon, Usha, Meyer, Jeffery, Miao, Hui, Miller, Nicola, Taib, Nur Aishah Mohd, Muir, Kenneth, Mulligan, Anna Marie, Mulot, Claire, Neuhausen, Susan L., Nevanlinna, Heli, Neven, Patrick, Nielsen, Sune F., Noh, Dong-Young, Nordestgaard, Børge G., Norman, Aaron, Olopade, Olufunmilayo I., Olson, Janet E., Olsson, Håkan, Olswold, Curtis, Orr, Nick, Pankratz, V. Shane, Park, Sue K., Park-Simon, Tjoung-Won, Lloyd, Rachel, Perez, Jose I. A., Peterlongo, Paolo, Peto, Julian, Phillips, Kelly-Anne, Pinchev, Mila, Plaseska-Karanfilska, Dijana, Prentice, Ross, Presneau, Nadege, Prokofyeva, Darya, Pugh, Elizabeth, Pylkäs, Katri, Rack, Brigitte, Radice, Paolo, Rahman, Nazneen, Rennert, Gadi, Rennert, Hedy S., Rhenius, Valerie, Romero, Atocha, Romm, Jane, Ruddy, Kathryn J., Rüdiger, Thomas, Rudolph, Anja, Ruebner, Matthias, Rutgers, Emiel J. T., Saloustros, Emmanouil, Sandler, Dale P., Sangrajrang, Suleeporn, Sawyer, Elinor J., Schmidt, Daniel F., Schmutzler, Rita K., Schneeweiss, Andreas, Schoemaker, Minouk J., Schumacher, Fredrick, Schürmann, Peter, Scott, Rodney J., Scott, Christopher, Seal, Sheila, Seynaeve, Caroline, Shah, Mitul, Sharma, Priyanka, Shen, Chen-Yang, Sheng, Grace, Sherman, Mark E., Shrubsole, Martha J., Shu, Xiao-Ou, Smeets, Ann, Sohn, Christof, Southey, Melissa C., Spinelli, John J., Stegmaier, Christa, Stewart-Brown, Sarah, Stone, Jennifer, Stram, Daniel O., Surowy, Harald, Swerdlow, Anthony, Tamimi, Rulla, Taylor, Jack A., Tengström, Maria, Teo, Soo H., Beth Terry, Mary, Tessier, Daniel C., Thanasitthichai, Somchai, Thöne, Kathrin, Tollenaar, Rob A. E. M., Tomlinson, Ian, Tong, Ling, Torres, Diana, Truong, Thérèse, Tseng, Chiu-Chen, Tsugane, Shoichiro, Ulmer, Hans-Ulrich, Ursin, Giske, Untch, Michael, Vachon, Celine, van Asperen, Christi J., Van Den Berg, David, van den Ouweland, Ans M. W., van der Kolk, Lizet, van der Luijt, Rob B., Vincent, Daniel, Vollenweider, Jason, Waisfisz, Quinten, Wang-Gohrke, Shan, Weinberg, Clarice R., Wendt, Camilla, Whittemore, Alice S., Wildiers, Hans, Willett, Walter, Winqvist, Robert, Wolk, Alicja, Wu, Anna H., Xia, Lucy, Yamaji, Taiki, Yang, Xiaohong R., Har Yip, Cheng, Yoo, Keun-Young, Yu, Jyh-Cherng, Zheng, Wei, Zheng, Ying, Zhu, Bin, Ziogas, Argyrios, Ziv, Elad, Lakhani, Sunil R., Antoniou, Antonis C., Droit, Arnaud, Andrulis, Irene L., Amos, Christopher I., Couch, Fergus J., Pharoah, Paul D. P., Chang-Claude, Jenny, Hall, Per, Hunter, David J., Milne, Roger L., García-Closas, Montserrat, Schmidt, Marjanka K., Chanock, Stephen J., Dunning, Alison M., Edwards, Stacey L., Bader, Gary D., Chenevix-Trench, Georgia, Simard, Jacques, Kraft, Peter, and Easton, Douglas F.

Published
2017
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19. A Personal Breast Cancer Risk Stratification Model Using Common Variants and Environmental Risk Factors in Japanese Females

Author

Oze, Isao, primary, Ito, Hidemi, additional, Kasugai, Yumiko, additional, Yamaji, Taiki, additional, Kijima, Yuko, additional, Ugai, Tomotaka, additional, Kasuga, Yoshio, additional, Ouellette, Tomoyo K., additional, Taniyama, Yukari, additional, Koyanagi, Yuriko N., additional, Imoto, Issei, additional, Tsugane, Shoichiro, additional, Koriyama, Chihaya, additional, Iwasaki, Motoki, additional, and Matsuo, Keitaro, additional

Published
2021
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22. Guidelines for obstetrical practice in Japan: Japan Society of Obstetrics and Gynecology (JSOG) and Japan Association of Obstetricians and Gynecologists (JAOG) 2014 edition

Author

Minakami, Hisanori, Maeda, Tsugio, Fujii, Tomoyuki, Hamada, Hiromi, Iitsuka, Yoshinori, Itakura, Atsuo, Itoh, Hiroaki, Iwashita, Mitsutoshi, Kanagawa, Takeshi, Kanai, Makoto, Kasuga, Yoshio, Kawabata, Masakiyo, Kobayashi, Kosuke, Kotani, Tomomi, Kudo, Yoshiki, Makino, Yasuo, Matsubara, Shigeki, Matsuda, Hideo, Miura, Kiyonori, Murakoshi, Takeshi, Murotsuki, Jun, Ohkuchi, Akihide, Ohno, Yasumasa, Ohshiba, Yoko, Satoh, Shoji, Sekizawa, Akihiko, Sugiura, Mayumi, Suzuki, Shunji, Takahashi, Tsuneo, Tsukahara, Yuki, Unno, Nobuya, and Yoshikawa, Hiroyuki

Published
2014
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23. Dietary isoflavone intake and breast cancer risk in case–control studies in Japanese, Japanese Brazilians, and non-Japanese Brazilians

Author

Iwasaki, Motoki, Hamada, Gerson Shigeaki, Nishimoto, Ines Nobuko, Netto, Mario Mourão, Motola, Jr., Juvenal, Laginha, Fábio Martins, Kasuga, Yoshio, Yokoyama, Shiro, Onuma, Hiroshi, Nishimura, Hideki, Kusama, Ritsu, Kobayashi, Minatsu, Ishihara, Junko, Yamamoto, Seiichiro, Hanaoka, Tomoyuki, and Tsugane, Shoichiro

Published
2009
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30. Genome-wide association study identifies breast cancer risk variant at 10q21.2: results from the Asia Breast Cancer Consortium

Author

Cai, Qiuyin, Long, Jirong, Lu, Wei, Qu, Shimian, Wen, Wanqing, Kang, Daehee, Lee, Ji-Young, Chen, Kexin, Shen, Hongbing, Shen, Chen-Yang, Sung, Hyuna, Matsuo, Keitaro, Haiman, Christopher A., Khoo, Ui Soon, Ren, Zefang, Iwasaki, Motoki, Gu, Kai, Xiang, Yong-Bing, Choi, Ji-Yeob, Park, Sue K., Zhang, Lina, Hu, Zhibin, Wu, Pei-Ei, Noh, Dong-Young, Tajima, Kazuo, Henderson, Brian E., Chan, Kelvin Y.K., Su, Fengxi, Kasuga, Yoshio, Wang, Wenjing, Cheng, Jia-Rong, Yoo, Keun-Young, Lee, Jong-Young, Zheng, Hong, Liu, Yao, Shieh, Ya-Lan, Kim, Sung-Won, Lee, Jong Won, Iwata, Hiroji, Le Marchand, Loic, Chan, Sum Yin, Xie, Xiaoming, Tsugane, Shoichiro, Lee, Min Hyuk, Wang, Shenming, Li, Guoliang, Levy, Shawn, Huang, Bo, Shi, Jiajun, Delahanty, Ryan, Zheng, Ying, Li, Chun, Gao, Yu-Tang, Shu, Xiao-Ou, and Zheng, Wei

Published
2011
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31. Guidelines for obstetrical practice in Japan: Japan Society of Obstetrics and Gynecology (JSOG) and Japan Association of Obstetricians and Gynecologists (JAOG) 2011 edition

Author

Minakami, Hisanori, Hiramatsu, Yuji, Koresawa, Mitsuhiko, Fujii, Tomoyuki, Hamada, Hiromi, Iitsuka, Yoshinori, Ikeda, Tomoaki, Ishikawa, Hiroshi, Ishimoto, Hitoshi, Itoh, Hiroaki, Kanayama, Naohiro, Kasuga, Yoshio, Kawabata, Masakiyo, Konishi, Ikuo, Matsubara, Shigeki, Matsuda, Hideo, Murakoshi, Takeshi, Ohkuchi, Akihide, Okai, Takashi, Saito, Shigeru, Sakai, Masato, Satoh, Shoji, Sekizawa, Akihiko, Suzuki, Masaaki, Takahashi, Tsuneo, Tokunaga, Akiteru, Tsukahara, Yuki, and Yoshikawa, Hiroyuki

Published
2011
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35. Isoflavone, polymorphisms in estrogen receptor genes and breast cancer risk in case-control studies in Japanese, Japanese Brazilians and non-Japanese Brazilians

Author

Iwasaki, Motoki, Hamada, Gerson Shigeaki, Nishimoto, Inês Nobuko, Netto, Mario Mourão, Motola, Juvenal, Jr, Laginha, Fábio Martins, Kasuga, Yoshio, Yokoyama, Shiro, Onuma, Hiroshi, Nishimura, Hideki, Kusama, Ritsu, Kobayashi, Minatsu, Ishihara, Junko, Yamamoto, Seiichiro, Hanaoka, Tomoyuki, and Tsugane, Shoichiro

Published
2009
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48. Association of postmenopausal endogenous sex hormones with global methylation level of leukocyte DNA among Japanese women

Author

Iwasaki Motoki, Ono Hiroe, Kuchiba Aya, Kasuga Yoshio, Yokoyama Shiro, Onuma Hiroshi, Nishimura Hideki, Kusama Ritsu, Yoshida Teruhiko, and Tsugane Shoichiro

Subjects
Cross-sectional study, Endogenous sex hormones, Global methylation level, Luminometric methylation assay, Peripheral blood leukocyte DNA, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282
Abstract

Abstract Background Although global hypomethylation of leukocyte DNA has been associated with an increased risk of several sites of cancer, including breast cancer, determinants of global methylation level among healthy individuals remain largely unexplored. Here, we examined whether postmenopausal endogenous sex hormones were associated with the global methylation level of leukocyte DNA. Methods A cross-sectional study was conducted using the control group of a breast cancer case–control study in Nagano, Japan. Subjects were postmenopausal women aged 55 years or over who provided blood samples. We measured global methylation level of peripheral blood leukocyte DNA by luminometric methylation assay; estradiol, estrone, androstenedione, dehydroepiandrosterone sulfate, testosterone and free testosterone by radioimmunoassay; bioavailable estradiol by the ammonium sulfate precipitation method; and sex-hormone binding globulin by immunoradiometric assay. A linear trend of association between methylation and hormone levels was evaluated by regression coefficients in a multivariable liner regression model. A total of 185 women were included in the analyses. Results Mean global methylation level (standard deviation) was 70.3% (3.1) and range was from 60.3% to 79.2%. Global methylation level decreased 0.27% per quartile category for estradiol and 0.39% per quartile category for estrone while it increased 0.41% per quartile category for bioavailable estradiol. However, we found no statistically significant association of any sex hormone level measured in the present study with global methylation level of leukocyte DNA. Conclusions Our findings suggest that endogenous sex hormones are not major determinants of the global methylation level of leukocyte DNA.

Published
2012
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49. Additional file 2: of Correlation between global methylation level of peripheral blood leukocytes and serum C reactive protein level modified by MTHFR polymorphism: a cross-sectional study

Author

Nojima, Masanori, Iwasaki, Motoki, Kasuga, Yoshio, Yokoyama, Shiro, Onuma, Hiroshi, Nishimura, Hideki, Ritsu Kusama, Teruhiko Yoshida, and Tsugane, Shoichiro

Abstract

Table S2. Assessment of association between HP infection and global methylation levels with/without adjustment with life-style factors, folate intake and serum CRP concentration. (DOCX 20 kb)

Published
2018
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50. Additional file 1: of Correlation between global methylation level of peripheral blood leukocytes and serum C reactive protein level modified by MTHFR polymorphism: a cross-sectional study

Author

Nojima, Masanori, Iwasaki, Motoki, Kasuga, Yoshio, Yokoyama, Shiro, Onuma, Hiroshi, Nishimura, Hideki, Ritsu Kusama, Teruhiko Yoshida, and Tsugane, Shoichiro

Abstract

Table S1. Details of the models for the assessment of CRP and global methylation in all subjects. (DOCX 19 kb)

Published
2018
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