345 results on '"Kasuga, Kensaku"'
Search Results
2. Combining plasma Aβ and p-tau217 improves detection of brain amyloid in non-demented elderly
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Niimi, Yoshiki, Janelidze, Shorena, Sato, Kenichiro, Tomita, Naoki, Tsukamoto, Tadashi, Kato, Takashi, Yoshiyama, Kenji, Kowa, Hisatomo, Iwata, Atsushi, Ihara, Ryoko, Suzuki, Kazushi, Kasuga, Kensaku, Ikeuchi, Takeshi, Ishii, Kenji, Ito, Kengo, Nakamura, Akinori, Senda, Michio, Day, Theresa A., Burnham, Samantha C., Iaccarino, Leonardo, Pontecorvo, Michael J., Hansson, Oskar, and Iwatsubo, Takeshi
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- 2024
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3. Polygenic effects on the risk of Alzheimer’s disease in the Japanese population
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Kikuchi, Masataka, Miyashita, Akinori, Hara, Norikazu, Kasuga, Kensaku, Saito, Yuko, Murayama, Shigeo, Kakita, Akiyoshi, Akatsu, Hiroyasu, Ozaki, Kouichi, Niida, Shumpei, Kuwano, Ryozo, Iwatsubo, Takeshi, Nakaya, Akihiro, and Ikeuchi, Takeshi
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- 2024
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4. γ-Secretase activity, clinical features, and biomarkers of autosomal dominant Alzheimer's disease: cross-sectional and longitudinal analysis of the Dominantly Inherited Alzheimer Network observational study (DIAN-OBS)
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Aguillon, David, Allegri, Ricardo F., Aschenbrenner, Andrew J., Baker, Bryce, Barthelemy, Nicolas, Bechara, Jacob A., Berman, Sarah B., Brooks, William S., Cash, David M., Chen, Allison, Chrem Mendez, Patricio, Courtney, Laura, Cruchaga, Carlos, Daniels, Alisha J., Fagan, Anne M., Flores, Shaney, Fox, Nick C., Franklin, Erin, Goate, Alison M., Graber-Sultan, Susanne, Graff-Radford, Neill R., Gremminger, Emily, Herries, Elizabeth, Hofmann, Anna, Holtzman, David M., Hornbeck, Russ, Huey, Edward D., Ibanez, Laura, Ikeuchi, Takeshi, Ikonomovic, Snezana, Jackson, Kelley, Jarman, Steve, Jerome, Gina, Johnson, Erik C.B, Kasuga, Kensaku, Keefe, Sarah, Koudelis, Deborah, Kuder-Buletta, Elke, Laske, Christoph, Leon, Yudy Milena, Levey, Allan I., Li, Yan, Llibre-Guerra, Jorge J., Lopera, Francisco, Lu, Ruijin, Marsh, Jacob, Martins, Ralph, Massoumzadeh, Parinaz, Masters, Colin, McCullough, Austin, McKay, Nicole, Minton, Matthew, Mori, Hiroshi, Morris, John C., Nadkarni, Neelesh K., Nicklaus, Joyce, Niimi, Yoshiki, Noble, James M., Obermueller, Ulrike, Picarello, Danielle M., Pulizos, Christine, Ramirez, Laura, Renton, Alan E., Ringman, John, Rizzo, Jacqueline, Roedenbeck, Yvonne, Roh, Jee Hoon, Rosa-Neto, Pedro, Ryan, Natalie S., Sabaredzovic, Edita, Salloway, Stephen, Sanchez-Valle, Raquel, Scott, Jalen, Seyfried, Nicholas T., Simmons, Ashlee, Smith, Jennifer, Smith, Hunter, Stauber, Jennifer, Stout, Sarah, Supnet-Bell, Charlene, Surace, Ezequiel, Vazquez, Silvia, Vöglein, Jonathan, Wang, Guoqiao, Wang, Qing, Xu, Xiong, Xu, Jinbin, Schultz, Stephanie A, Liu, Lei, Schultz, Aaron P, Fitzpatrick, Colleen D, Levin, Raina, Bellier, Jean-Pierre, Shirzadi, Zahra, Joseph-Mathurin, Nelly, Chen, Charles D, Benzinger, Tammie L S, Day, Gregory S, Farlow, Martin R, Gordon, Brian A, Hassenstab, Jason J, Jack, Clifford R, Jr, Jucker, Mathias, Karch, Celeste M, Lee, Jae-Hong, Levin, Johannes, Perrin, Richard J, Schofield, Peter R, Xiong, Chengjie, Johnson, Keith A, McDade, Eric, Bateman, Randall J, Sperling, Reisa A, Selkoe, Dennis J, and Chhatwal, Jasmeer P
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- 2024
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5. Trait-anxiety and glial-related neuroinflammation of the amygdala and its associated regions in Alzheimer's disease: A significant correlation
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Yasuno, Fumihiko, Kimura, Yasuyuki, Ogata, Aya, Ikenuma, Hiroshi, Abe, Junichiro, Minami, Hiroyuki, Nihashi, Takashi, Yokoi, Kastunori, Hattori, Saori, Shimoda, Nobuyoshi, Watanabe, Atsushi, Kasuga, Kensaku, Ikeuchi, Takeshi, Takeda, Akinori, Sakurai, Takashi, Ito, Kengo, and Kato, Takashi
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- 2024
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6. Comparison of tau spread in people with Down syndrome versus autosomal-dominant Alzheimer's disease: a cross-sectional study
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Aizenstein, Howard J., Andrews, Howard F., Bell, Karen, Birn, Rasmus M., Bulova, Peter, Cheema, Amrita, Chen, Kewei, Clare, Isabel, Clark, Lorraine, Cohen, Ann D., Constantino, John N., Doran, Eric W., Feingold, Eleanor, Foroud, Tatiana M., Hartley, Sigan L., Hom, Christy, Honig, Lawrence, Ikonomovic, Milos D., Johnson, Sterling C., Jordan, Courtney, Kamboh, M. Ilyas, Keator, David, Klunk, William E., Kofler, Julia K., Kreisl, William C., Krinsky-McHale, Sharon J., Lao, Patrick, Laymon, Charles, Lott, Ira T., Lupson, Victoria, Mathis, Chester A., Minhas, Davneet S., Nadkarni, Neelesh, Pang, Deborah, Petersen, Melissa, Price, Julie C., Pulsifer, Margaret, Reiman, Eric, Rizvi, Batool, Sabbagh, Marwan N., Schupf, Nicole, Tudorascu, Dana L., Tumuluru, Rameshwari, Tycko, Benjamin, Varadarajan, Badri, White, Desiree A., Yassa, Michael A., Zaman, Shahid, Zhang, Fan, Bateman, Randall, Daniels, Alisha J., Courtney, Laura, McDade, Eric, Llibre-Guerra, Jorge J., Supnet-Bell, Charlene, Xiong, Chengie, Xu, Xiong, Lu, Ruijin, Wang, Guoqiao, Li, Yan, Gremminger, Emily, Perrin, Richard J., Franklin, Erin, Ibanez, Laura, Jerome, Gina, Herries, Elizabeth, Stauber, Jennifer, Baker, Bryce, Minton, Matthew, Cruchaga, Carlos, Goate, Alison M., Renton, Alan E., Picarello, Danielle M., Benzinger, Tammie, Gordon, Brian A., Hornbeck, Russall, Hassenstab, Jason, Smith, Jennifer, Stout, Sarah, Aschenbrenner, Andrew J., Karch, Celeste M., Marsh, Jacob, Morris, John C., Holtzman, David M., Barthelemy, Nicolas, Xu, Jinbin, Noble, James M., Berman, Sarah B., Ikonomovic, Snezana, Nadkarni, Neelesh K., Day, Gregory, Graff-Radford, Neill R., Farlow, Martin, Chhatwal, Jasmeer P., Ikeuchi, Takeshi, Kasuga, Kensaku, Niimi, Yoshiki, Huey, Edward D., Salloway, Stephen, Schofield, Peter R., Brooks, William S., Bechara, Jacob A., Martins, Ralph, Fox, Nick C., Cash, David M., Ryan, Natalie S., Jucker, Mathias, Laske, Christoph, Hofmann, Anna, Kuder-Buletta, Elke, Graber-Sultan, Susanne, Obermueller, Ulrike, Levin, Johannes, Roedenbeck, Yvonne, Vöglein, Jonathan, Lee, Jae-Hong, Roh, Jee Hoon, Sanchez-Valle, Raquel, Rosa-Neto, Pedro, Allegri, Ricardo F., Chrem Mendez, Patricio, Surace, Ezequiel, Vazquez, Silvia, Lopera, Francisco, Leon, Yudy Milena, Ramirez, Laura, Aguillon, David, Levey, Allan I., Johnson, Erik C.B, Seyfried, Nicholas T., Ringman, John, Mori, Hiroshi, Wisch, Julie K, McKay, Nicole S, Boerwinkle, Anna H, Kennedy, James, Flores, Shaney, Handen, Benjamin L, Christian, Bradley T, Head, Elizabeth, Mapstone, Mark, Rafii, Michael S, O’Bryant, Sid E, Price, Julie C, Laymon, Charles M, Krinsky-McHale, Sharon J, Lai, Florence, Rosas, H Diana, Hartley, Sigan L, Lott, Ira T, Tudorascu, Dana, Zammit, Matthew, Brickman, Adam M, Lee, Joseph H, Bird, Thomas D, Cohen, Annie, Chrem, Patricio, Daniels, Alisha, Chhatwal, Jasmeer P, Karch, Celeste M, Day, Gregory S, Llibre-Guerra, Jorge, Ringman, John M, van Dyck, Christopher H, Xiong, Chengjie, Morris, John C, Bateman, Randall J, Benzinger, Tammie L S, Gordon, Brian A, and Ances, Beau M
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- 2024
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7. Deconstructing pathological tau by biological process in early stages of Alzheimer disease: a method for quantifying tau spatial spread in neuroimaging
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Noble, James M., Day, Gregory S., Graff-Radford, Neill R., Voglein, Jonathan, Levin, Johannes, Allegri, Ricardo F., Mendez, Patricio Chrem, Surace, Ezequiel, Berman, Sarah B., Ikonomovic, Snezana, Nadkarni, Neelesh K., Lopera, Francisco, Ramirez, Laura, Aguillon, David, Leon, Yudy, Ramos, Claudia, Alzate, Diana, Baena, Ana, Londono, Natalia, Moreno, Sonia, Jucker, Mathias, Laske, Christoph, Kuder-Buletta, Elke, Graber-Sultan, Susanne, Preische, Oliver, Hofmann, Anna, Ikeuchi, Takeshi, Kasuga, Kensaku, Niimi, Yoshiki, Ishii, Kenji, Senda, Michio, Sanchez-Valle, Raquel, Rosa-Neto, Pedro, Fox, Nick C., Cash, Dave, Lee, Jae-Hong, Roh, Jee Hoon, Salloway, Stephen, Riddle, Meghan C., Menard, William, Bodge, Courtney, Surti, Mustafa, Takada, Leonel Tadao, Farlow, Martin, Chhatwal, Jasmeer P., Sanchez-Gonzalez, V.J., Orozco-Barajas, Maribel, Goate, Alison M., Renton, Alan E., Esposito, Bianca T., Karch, Celeste M., Marsh, Jacob, Cruchaga, Carlos, Fernanadez, Victoria, Gordon, Brian A., Fagan, Anne M., Jerome, Gina, Herries, Elizabeth, Llibre-Guerra, Jorge, Levey, Allan I., Johnson, Erik C.B., Seyfried, Nicholas T., Schofield, Peter R., Brooks, William S., Bechara, Jacob A., Bateman, Randall, McDade, Eric, Hassenstab, Jason, Perrin, Richard J., Franklin, Erin E., Benzinger, Tammie, Chen, Allison, Chen, Charles, Flores, Shaney, Friedrichsen, Nelly, Gordon, Brian, Hantler, Nancy, Hornbeck, Russ, Jarman, Steve, Keefe, Sarah, Koudelis, Deborah, Massoumzadeh, Parinaz, McCullough, Austin, McKay, Nicole, Nicklaus, Joyce, Pulizos, Christine, Wang, Qing, Mishall, Sheetal, Sabaredzovic, Edita, Deng, Emily, Candela, Madison, Smith, Hunter, Hobbs, Diana, Scott, Jalen, Xiong, Chengjie, Wang, Peter, Xu, Xiong, Li, Yan, Gremminger, Emily, Ma, Yinjiao, Bui, Ryan, Lu, Ruijin, Martins, Ralph, Sosa Ortiz, Ana Luisa, Daniels, Alisha, Courtney, Laura, Mori, Hiroshi, Supnet-Bell, Charlene, Xu, Jinbin, Ringman, John, Barthelemy, Nicolas, Morris, John, Smith, Jennifer, Doering, Stephanie, Chen, Charles D., Jarman, Stephen, Jackson, Kelley, Hornbeck, Russ C., Ances, Beau M., Aschenbrenner, Andrew J., Bateman, Randall J., Morris, John C., and Benzinger, Tammie L.S.
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- 2024
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8. Sex difference in evolution of cognitive decline: studies on mouse model and the Dominantly Inherited Alzheimer Network cohort
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Kommaddi, Reddy Peera, Verma, Aditi, Muniz-Terrera, Graciela, Tiwari, Vivek, Chithanathan, Keerthana, Diwakar, Latha, Gowaikar, Ruturaj, Karunakaran, Smitha, Malo, Palash Kumar, Graff-Radford, Neill R., Day, Gregory S., Laske, Christoph, Vöglein, Jonathan, Nübling, Georg, Ikeuchi, Takeshi, Kasuga, Kensaku, and Ravindranath, Vijayalakshmi
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- 2023
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9. Demographic, clinical, biomarker, and neuropathological correlates of posterior cortical atrophy: an international cohort study and individual participant data meta-analysis
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Abdi, Zeinab, Agosta, Federica, Ahmed, Samrah, Alcolea, Daniel, Allen, Isabel Elaine, Allinson, Kieren S.J., Apostolova, Liana G., Arighi, Andrea, Balasa, Mircea, Barkhof, Frederik, Best, John, Boon, Baayla D., Brandt, Katherine D., Brosch, Jared, Burrell, James, Butler, Christopher R., Calandri, Ismael, Caminiti, Silvia Paola, Canu, Elisa, Carrillo, Maria C., Caso, Francesca, Chapleau, Marianne, Chrem Mendez, Patricio, Chu, Min, Crutch, Sebastian, Cordato, Nicholas, Costa, Ana Sofia, Cui, Yue, Dickerson, Bradford, Dickson, Dennis W., Duara, Ranjan, Dubois, Bruno, Eldaief, Mark, Farlow, Martin, Fenoglio, Chiara, Filippi, Massimo, Fliessbach, Klaus, Formaglio, Maïté, Fortea, Juan, Fox, Nick, Foxe, David, Tilikete, Caroline Froment, Frosch, Matthew P., Fumagalli, Giorgio Giulio, Galasko, Douglas, Galimberti, Daniela, Garat, Oscar, Giardinieri, Giulia, Graff-Radford, Jonathan, Graff-Radford, Neill R., Grinberg, Lea, Groot, Colin, Hake, Ann Marie, Hansson, Oskar, Headley, Alison, Hernandez, Micaela, Hochberg, Daisy, Hodges, John R., Hof, Patrick R., Holton, Janice, Hromas, Gabrielle, Gala, Ignacio Illán, Irwin, David J., Jaunmuktane, Zane, Jing, Donglai, Josephs, Keith, Kagerer, Sonja M., Kasuga, Kensaku, Kong, Yu, Kövari, Enikö, Lacombe-Thibault, Mégane, Lleó, Alberto, Laforce, Robert, La Joie, Renaud, Lashley, Tammaryn, Leger, Gabriel, Levin, Netta, Levy, Richard, Liu, Yang, Liu, Li, Lladó Plarrumaní, Albert, Lucente, Diane E., Machulda, Mary M., Magnani, Giuseppe, Magnin, Eloi, Malpetti, Maura, Matthews, Brandy, McGinnis, Scott, Mendez, Mario F., Mesulam, Marsel, Migliaccio, Raffaella, Miklitz, Carolin, Miller, Zachary A., Montembeault, Maxime, Murray, Melissa E., Mundada, Nidhi, Nemes, Sara, Nestor, Peter J., Ocal, Dilek, Ossenkoppele, Rik, Paterson, Ross, Pelak, Victoria, Perani, Daniela, Phillips, Jeffrey, Piguet, Olivier, Pijnenburg, Yolande, Putcha, Deepti, Quimby, Megan, Rabinovici, Gil D., Reetz, Kathrin, Rein, Netaniel, Revesz, Tamas, Rezaii, Neguine, Rodriguez-Porcel, Federico, Rogalski, Emily, Rowe, James B., Ryan, Natalie, Sanchez-Valle, Raquel, Sacchi, Luca, Santos-Santos, Miguel Ángel, Schott, Jonathan M., Seeley, William, Sherman, Janet, Spina, Salvatore, Stomrud, Erik, Sullivan, A. Campbell, Tanner, Jeremy, Tideman, Pontus, Tokutake, Takayoshi, Tondo, Giacomo, Touroutoglou, Alexandra, Tousi, Babak, Vandenberghe, Rik, van der Flier, Wiesje, Walker, Jamie M., Weintraub, Sandra, Whitwell, Jennifer L., Wolk, David A., Wong, Bonnie, Wu, Liyong, Xie, Kexin, Yong, Keir, Apostolova, Liana, Boon, Baayla D C, Grinberg, Lea T, Irwin, David J, Josephs, Keith A, Mendez, Mario F, Mendez, Patricio Chrem, Miller, Zachary A, Murray, Melissa E, Nemes, Sára, Schott, Jonathan M, Sullivan, A Campbell, Walker, Jamie, Whitwell, Jennifer L, Wolk, David A, and Rabinovici, Gil D
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- 2024
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10. Neuroimaging biomarkers of glial activation for predicting the annual cognitive function decline in patients with Alzheimer’s disease
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Yasuno, Fumihiko, Kimura, Yasuyuki, Ogata, Aya, Ikenuma, Hiroshi, Abe, Junichiro, Minami, Hiroyuki, Nihashi, Takashi, Yokoi, Kastunori, Hattori, Saori, Shimoda, Nobuyoshi, Watanabe, Atsushi, Kasuga, Kensaku, Ikeuchi, Takeshi, Takeda, Akinori, Sakurai, Takashi, Ito, Kengo, and Kato, Takashi
- Published
- 2023
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11. Soluble form of the APP fragment, sAPPβ, positively regulates tau secretion
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Sato, Haruaki, Kasuga, Kensaku, Isoo, Noriko, Hayashi, Toshihiro, Ikeuchi, Takeshi, Hori, Yukiko, and Tomita, Taisuke
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- 2023
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12. The clinical application of optimized AT(N) classification in Alzheimer’s clinical syndrome (ACS) and non-ACS conditions
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Kasuga, Kensaku, Tsukie, Tamao, Kikuchi, Masataka, Tokutake, Takayoshi, Washiyama, Kazuo, Shimizu, Soichiro, Yoshizawa, Hiroshi, Kuroha, Yasuko, Yajima, Ryuji, Mori, Hiroshi, Arakawa, Yasuaki, Onda, Kiyoshi, Miyashita, Akinori, Onodera, Osamu, Iwatsubo, Takeshi, and Ikeuchi, Takeshi
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- 2023
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13. Comparison of amyloid burden in individuals with Down syndrome versus autosomal dominant Alzheimer's disease: a cross-sectional study
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Aizenstein, Howard J, Andrews, Howard F, Bell, Karen, Birn, Rasmus M, Bulova, Peter, Cheema, Amrita, Chen, Kewei, Clare, Isabel, Clark, Lorraine, Cohen, Ann D, Constantino, John N, Doran, Eric W, Feingold, Eleanor, Foroud, Tatiana M, Hartley, Sigan L, Hom, Christy, Honig, Lawrence, Ikonomovic, Milos D, Johnson, Sterling C, Jordan, Courtney, Kamboh, M Ilyas, Keator, David, Klunk MD, William E, Kofler, Julia K, Kreisl, William C, Krinsky- McHale, Sharon J, Lao, Patrick, Laymon, Charles, Lott, Ira T, Lupson, Victoria, Mathis, Chester A, Minhas, Davneet S, Nadkarni, Neelesh, Pang, Deborah, Petersen, Melissa, Price, Julie C, Pulsifer, Margaret, Reiman, Eric, Rizvi, Batool, Sabbagh, Marwan N, Schupf, Nicole, Tudorascu, Dana L, Tumuluru, Rameshwari, Tycko, Benjamin, Varadarajan, Badri, White, Desiree A, Yassa, Michael A, Zaman, Shahid, Zhang, Fan, Adams, Sarah, Allegri, Ricardo, Araki, Aki, Barthelemy, Nicolas, Bechara, Jacob, Berman, Sarah, Bodge, Courtney, Brandon, Susan, Brooks, William, Brosch, Jared, Buck, Jill, Buckles, Virginia, Carter, Kathleen, Cash, Lisa, Mendez, Patricio C, Chua, Jasmin, Chui, Helena, Courtney, Laura, Day, Gregory, DeLaCruz, Chrismary, Denner, Darcy, Diffenbacher, Anna, Dincer, Aylin, Donahue, Tamara, Douglas, Jane, Duong, Duc, Egido, Noelia, Esposito, Bianca, Farlow, Marty, Feldman, Becca, Fitzpatrick, Colleen, Fox, Nick, Franklin, Erin, Joseph-Mathurin, Nelly, Fujii, Hisako, Gardener, Samantha, Ghetti, Bernardino, Goate, Alison, Goldberg, Sarah, Goldman, Jill, Gonzalez, Alyssa, Gräber-Sultan, Susanne, Graff-Radford, Neill, Graham, Morgan, Gray, Julia, Gremminger, Emily, Grilo, Miguel, Groves, Alex, Haass, Christian, Häslerc, Lisa, Hellm, Cortaiga, Herries, Elizabeth, Hoechst-Swisher, Laura, Hofmann, Anna, Holtzman, David, Hornbeck, Russ, Igor, Yakushev, Ihara, Ryoko, Ikeuchi, Takeshi, Ikonomovic, Snezana, Ishii, Kenji, Jack, Clifford, Jerome, Gina, Johnson, Erik, Jucker, Mathias, Karch, Celeste, Käser, Stephan, Kasuga, Kensaku, Keefe, Sarah, Klunk, William, Koeppe, Robert, Koudelis, Deb, Kuder-Buletta, Elke, Laske, Christoph, Levey, Allan, Levin, Johannes, Li, Yan, Lopez, Oscar, Marsh, Jacob, Martins, Ralph, Mason, Neal S, Masters, Colin, Mawuenyega, Kwasi, McCullough, Austin, Mejia, Arlene, Morenas-Rodriguez, Estrella, Morris, John C, Mountz, James, Mummery, Catherine, Nagamatsu, Akemi, Neimeyer, Katie, Niimi, Yoshiki, Noble, James, Norton, Joanne, Nuscher, Brigitte, Obermüller, Ulricke, O'Connor, Antoinette, Patira, Riddhi, Ping, Lingyan, Preische, Oliver, Renton, Alan, Ringman, John, Salloway, Stephen, Schofield, Peter, Senda, Michio, Seyfried, Nicholas T, Shady, Kristine, Shimada, Hiroyuki, Sigurdson, Wendy, Smith, Jennifer, Smith, Lori, Snitz, Beth, Sohrabi, Hamid, Stephens, Sochenda, Taddei, Kevin, Thompson, Sarah, Vöglein, Jonathan, Wang, Peter, Wang, Qing, Weamer, Elise, Xu, Jinbin, Xu, Xiong, Boerwinkle, Anna H, Gordon, Brian A, Wisch, Julie, Flores, Shaney, Henson, Rachel L, Butt, Omar H, McKay, Nicole, Chen, Charles D, Benzinger, Tammie L S, Fagan, Anne M, Handen, Benjamin L, Christian, Bradley T, Head, Elizabeth, Mapstone, Mark, Rafii, Michael S, O'Bryant, Sid, Lai, Florence, Rosas, H Diana, Lee, Joseph H, Silverman, Wayne, Brickman, Adam M, Chhatwal, Jasmeer P, Cruchaga, Carlos, Perrin, Richard J, Xiong, Chengjie, Hassenstab, Jason, McDade, Eric, Bateman, Randall J, and Ances, Beau M
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- 2023
- Full Text
- View/download PDF
14. Deconstructing pathological tau by biological process in early stages of Alzheimer disease: a method for quantifying tau spatial spread in neuroimaging
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Doering, Stephanie, primary, McCullough, Austin, additional, Gordon, Brian A., additional, Chen, Charles D., additional, McKay, Nicole, additional, Hobbs, Diana, additional, Keefe, Sarah, additional, Flores, Shaney, additional, Scott, Jalen, additional, Smith, Hunter, additional, Jarman, Stephen, additional, Jackson, Kelley, additional, Hornbeck, Russ C., additional, Ances, Beau M., additional, Xiong, Chengjie, additional, Aschenbrenner, Andrew J., additional, Hassenstab, Jason, additional, Cruchaga, Carlos, additional, Daniels, Alisha, additional, Bateman, Randall J., additional, Noble, James M., additional, Day, Gregory S., additional, Graff-Radford, Neill R., additional, Voglein, Jonathan, additional, Levin, Johannes, additional, Allegri, Ricardo F., additional, Mendez, Patricio Chrem, additional, Surace, Ezequiel, additional, Berman, Sarah B., additional, Ikonomovic, Snezana, additional, Nadkarni, Neelesh K., additional, Lopera, Francisco, additional, Ramirez, Laura, additional, Aguillon, David, additional, Leon, Yudy, additional, Ramos, Claudia, additional, Alzate, Diana, additional, Baena, Ana, additional, Londono, Natalia, additional, Moreno, Sonia, additional, Jucker, Mathias, additional, Laske, Christoph, additional, Kuder-Buletta, Elke, additional, Graber-Sultan, Susanne, additional, Preische, Oliver, additional, Hofmann, Anna, additional, Ikeuchi, Takeshi, additional, Kasuga, Kensaku, additional, Niimi, Yoshiki, additional, Ishii, Kenji, additional, Senda, Michio, additional, Sanchez-Valle, Raquel, additional, Rosa-Neto, Pedro, additional, Fox, Nick C., additional, Cash, Dave, additional, Lee, Jae-Hong, additional, Roh, Jee Hoon, additional, Salloway, Stephen, additional, Riddle, Meghan C., additional, Menard, William, additional, Bodge, Courtney, additional, Surti, Mustafa, additional, Takada, Leonel Tadao, additional, Farlow, Martin, additional, Chhatwal, Jasmeer P., additional, Sanchez-Gonzalez, V.J., additional, Orozco-Barajas, Maribel, additional, Goate, Alison M., additional, Renton, Alan E., additional, Esposito, Bianca T., additional, Karch, Celeste M., additional, Marsh, Jacob, additional, Fernanadez, Victoria, additional, Fagan, Anne M., additional, Jerome, Gina, additional, Herries, Elizabeth, additional, Llibre-Guerra, Jorge, additional, Levey, Allan I., additional, Johnson, Erik C.B., additional, Seyfried, Nicholas T., additional, Schofield, Peter R., additional, Brooks, William S., additional, Bechara, Jacob A., additional, Bateman, Randall, additional, McDade, Eric, additional, Perrin, Richard J., additional, Franklin, Erin E., additional, Benzinger, Tammie, additional, Chen, Allison, additional, Chen, Charles, additional, Friedrichsen, Nelly, additional, Gordon, Brian, additional, Hantler, Nancy, additional, Hornbeck, Russ, additional, Jarman, Steve, additional, Koudelis, Deborah, additional, Massoumzadeh, Parinaz, additional, Nicklaus, Joyce, additional, Pulizos, Christine, additional, Wang, Qing, additional, Mishall, Sheetal, additional, Sabaredzovic, Edita, additional, Deng, Emily, additional, Candela, Madison, additional, Wang, Peter, additional, Xu, Xiong, additional, Li, Yan, additional, Gremminger, Emily, additional, Ma, Yinjiao, additional, Bui, Ryan, additional, Lu, Ruijin, additional, Martins, Ralph, additional, Sosa Ortiz, Ana Luisa, additional, Courtney, Laura, additional, Mori, Hiroshi, additional, Supnet-Bell, Charlene, additional, Xu, Jinbin, additional, Ringman, John, additional, Barthelemy, Nicolas, additional, Morris, John, additional, Smith, Jennifer, additional, Morris, John C., additional, and Benzinger, Tammie L.S., additional
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- 2024
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15. Clinical correlations of cerebrospinal fluid biomarkers including neuron-glia 2 and neurofilament light chain in patients with multiple system atrophy
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Tokutake, Takayoshi, Kasuga, Kensaku, Tsukie, Tamao, Ishiguro, Takanobu, Shimohata, Takayoshi, Onodera, Osamu, and Ikeuchi, Takeshi
- Published
- 2022
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16. Predicting brain age from functional connectivity in symptomatic and preclinical Alzheimer disease
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Adams, Sarah, Allegri, Ricardo, Araki, Aki, Barthelemy, Nicolas, Bateman, Randall, Bechara, Jacob, Benzinger, Tammie, Berman, Sarah, Bodge, Courtney, Brandon, Susan, Brooks, William (Bill), Brosch, Jared, Buck, Jill, Buckles, Virginia, Carter, Kathleen, Cash, Lisa, Chen, Charlie, Chhatwal, Jasmeer, Mendez, Patricio Chrem, Chua, Jasmin, Chui, Helena, Courtney, Laura, Cruchaga, Carlos, Day, Gregory S, DeLaCruz, Chrismary, Denner, Darcy, Diffenbacher, Anna, Dincer, Aylin, Donahue, Tamara, Douglas, Jane, Duong, Duc, Egido, Noelia, Esposito, Bianca, Fagan, Anne, Farlow, Marty, Feldman, Becca, Fitzpatrick, Colleen, Flores, Shaney, Fox, Nick, Franklin, Erin, Joseph-Mathurin, Nelly, Fujii, Hisako, Gardener, Samantha, Ghetti, Bernardino, Goate, Alison, Goldberg, Sarah, Goldman, Jill, Gonzalez, Alyssa, Gordon, Brian, Gräber-Sultan, Susanne, Graff-Radford, Neill, Graham, Morgan, Gray, Julia, Gremminger, Emily, Grilo, Miguel, Groves, Alex, Haass, Christian, Häsler, Lisa, Hassenstab, Jason, Hellm, Cortaiga, Herries, Elizabeth, Hoechst-Swisher, Laura, Hofmann, Anna, Holtzman, David, Hornbeck, Russ, Igor, Yakushev, Ihara, Ryoko, Ikeuchi, Takeshi, Ikonomovic, Snezana, Ishii, Kenji, Jack, Clifford, Jerome, Gina, Johnson, Erik, Jucker, Mathias, Karch, Celeste, Käser, Stephan, Kasuga, Kensaku, Keefe, Sarah, Klunk, William, Koeppe, Robert, Koudelis, Deb, Kuder-Buletta, Elke, Laske, Christoph, Levey, Allan, Levin, Johannes, Li, Yan, Lopez, Oscar, Marsh, Jacob, Martins, Ralph, Mason, Neal Scott, Masters, Colin, Mawuenyega, Kwasi, McCullough, Austin, McDade, Eric, Mejia, Arlene, Morenas-Rodriguez, Estrella, Morris, John, Mountz, James, Mummery, Cath, Nadkarni, N eelesh, Nagamatsu, Akemi, Neimeyer, Katie, Niimi, Yoshiki, Noble, James, Norton, Joanne, Nuscher, Brigitte, Obermüller, Ulricke, O'Connor, Antoinette, Patira, Riddhi, Perrin, Richard, Ping, Lingyan, Preische, Oliver, Renton, Alan, Ringman, John, Salloway, Stephen, Schofield, Peter, Senda, Michio, Seyfried, Nicholas T, Shady, Kristine, Shimada, Hiroyuki, Sigurdson, Wendy, Smith, Jennifer, Smith, Lori, Snitz, Beth, Sohrabi, Hamid, Stephens, Sochenda, Taddei, Kevin, Thompson, Sarah, Vöglein, Jonathan, Wang, Peter, Wang, Qing, Weamer, Elise, Xiong, Chengjie, Xu, Jinbin, Xu, Xiong, Millar, Peter R., Luckett, Patrick H., Gordon, Brian A., Benzinger, Tammie L.S., Schindler, Suzanne E., Fagan, Anne M., Bateman, Randall J., Lee, Jae-Hong, Mori, Hiroshi, Salloway, Stephen P, Yakushev, Igor, Morris, John C., and Ances, Beau M.
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- 2022
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17. Soluble TREM2 in CSF and its association with other biomarkers and cognition in autosomal-dominant Alzheimer's disease: a longitudinal observational study
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Adams, Sarah, Allegri, Ricardo, Araki, Aki, Barthelemy, Nicolas, Bechara, Jacob, Berman, Sarah, Bodge, Courtney, Brandon, Susan, Brooks, William (Bill), Brosch, Jared, Buck, Jill, Buckles, Virginia, Carter, Kathleen, Cash, Lisa, Chen, Charlie, Chhatwal, Jasmeer, Chrem, Patricio, Chua, Jasmin, Chui, Helena, Cruchaga, Carlos, Day, Gregory S, De La Cruz, Chrismary, Denner, Darcy, Diffenbacher, Anna, Dincer, Aylin, Donahue, Tamara, Douglas, Jane, Duong, Duc, Egido, Noelia, Esposito, Bianca, Farlow, Marty, Feldman, Becca, Fitzpatrick, Colleen, Flores, Shaney, Fox, Nick, Franklin, Erin, Friedrichsen, Nelly, Fujii, Hisako, Gardener, Samantha, Ghetti, Bernardino, Goate, Alison, Goldberg, Sarah, Goldman, Jill, Gonzalez, Alyssa, Gräber-Sultan, Susanne, Graff-Radford, Neill, Graham, Morgan, Gray, Julia, Gremminger, Emily, Grilo, Miguel, Groves, Alex, Häsler, Lisa, Hellm, Cortaiga, Herries, Elizabeth, Hoechst-Swisher, Laura, Hofmann, Anna, Holtzman, David, Hornbeck, Russ, Igor, Yakushev, Ihara, Ryoko, Ikeuchi, Takeshi, Ikonomovic, Snezana, Ishii, Kenji, Jack, Clifford, Jerome, Gina, Johnson, Erik, Käser, Stephan, Kasuga, Kensaku, Keefe, Sarah, Klunk, William (Bill), Koeppe, Robert, Koudelis, Deb, Kuder-Buletta, Elke, Laske, Christoph, Levey, Allan, Lopez, Oscar, Marsh, Jacob, Martinez, Rita, Martins, Ralph, Mason, Neal Scott, Masters, Colin, Mawuenyega, Kwasi, McCullough, Austin, Mejia, Arlene, MountzMD, James, Mummery, Cath, Nadkarni, Neelesh, Nagamatsu, Akemi, Neimeyer, Katie, Niimi, Yoshiki, Noble, James, Norton, Joanne, Nuscher, Brigitte, O'Connor, Antoinette, Obermüller, Ulricke, Patira, Riddhi, Perrin, Richard, Ping, Lingyan, Preische, Oliver, Renton, Alan, Ringman, John, Salloway, Stephen, Schofield, Peter, Senda, Michio, Seyfried, Nick, Shady, Kristine, Shimada, Hiroyuki, Sigurdson, Wendy, Smith, Jennifer, Smith, Lori, Snitz, Beth, Sohrabi, Hamid, Stephens, Sochenda, Taddei, Kevin, Thompson, Sarah, Wang, Peter, Wang, Qing, Weamer, Elise, Xu, Jinbin, Xu, Xiong, Morenas-Rodríguez, Estrella, Li, Yan, Franzmeier, Nicolai, Xiong, Chengjie, Suárez-Calvet, Marc, Fagan, Anne M, Schultz, Stephanie, Gordon, Brian A, Benzinger, Tammie L S, Hassenstab, Jason, McDade, Eric, Feederle, Regina, Karch, Celeste M, Schlepckow, Kai, Morris, John C, Kleinberger, Gernot, Nellgard, Bengt, Vöglein, Jonathan, Blennow, Kaj, Zetterberg, Henrik, Ewers, Michael, Jucker, Mathias, Levin, Johannes, Bateman, Randall J, and Haass, Christian
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- 2022
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18. Identification of mild cognitive impairment subtypes predicting conversion to Alzheimer’s disease using multimodal data
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Kikuchi, Masataka, Kobayashi, Kaori, Itoh, Sakiko, Kasuga, Kensaku, Miyashita, Akinori, Ikeuchi, Takeshi, Yumoto, Eiji, Kosaka, Yuki, Fushimi, Yasuto, Takeda, Toshihiro, Manabe, Shirou, Hattori, Satoshi, Nakaya, Akihiro, Kamijo, Kenichi, and Matsumura, Yasushi
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- 2022
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19. Demographic, clinical, biomarker, and neuropathological correlates of posterior cortical atrophy: an international cohort study and individual participant data meta-analysis
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Chapleau, Marianne, primary, La Joie, Renaud, additional, Yong, Keir, additional, Agosta, Federica, additional, Allen, Isabel Elaine, additional, Apostolova, Liana, additional, Best, John, additional, Boon, Baayla D C, additional, Crutch, Sebastian, additional, Filippi, Massimo, additional, Fumagalli, Giorgio Giulio, additional, Galimberti, Daniela, additional, Graff-Radford, Jonathan, additional, Grinberg, Lea T, additional, Irwin, David J, additional, Josephs, Keith A, additional, Mendez, Mario F, additional, Mendez, Patricio Chrem, additional, Migliaccio, Raffaella, additional, Miller, Zachary A, additional, Montembeault, Maxime, additional, Murray, Melissa E, additional, Nemes, Sára, additional, Pelak, Victoria, additional, Perani, Daniela, additional, Phillips, Jeffrey, additional, Pijnenburg, Yolande, additional, Rogalski, Emily, additional, Schott, Jonathan M, additional, Seeley, William, additional, Sullivan, A Campbell, additional, Spina, Salvatore, additional, Tanner, Jeremy, additional, Walker, Jamie, additional, Whitwell, Jennifer L, additional, Wolk, David A, additional, Ossenkoppele, Rik, additional, Rabinovici, Gil D, additional, Abdi, Zeinab, additional, Ahmed, Samrah, additional, Alcolea, Daniel, additional, Allinson, Kieren S.J., additional, Arighi, Andrea, additional, Balasa, Mircea, additional, Barkhof, Frederik, additional, Brandt, Katherine D., additional, Brosch, Jared, additional, Burrell, James, additional, Butler, Christopher R., additional, Calandri, Ismael, additional, Caminiti, Silvia Paola, additional, Canu, Elisa, additional, Carrillo, Maria C., additional, Caso, Francesca, additional, Chu, Min, additional, Cordato, Nicholas, additional, Costa, Ana Sofia, additional, Cui, Yue, additional, Dickerson, Bradford, additional, Dickson, Dennis W., additional, Duara, Ranjan, additional, Dubois, Bruno, additional, Eldaief, Mark, additional, Farlow, Martin, additional, Feneglio, Chiara, additional, Fliessbach, Klaus, additional, Formaglio, Maïté, additional, Fortea, Juan, additional, Fox, Nick, additional, Foxe, David, additional, Tilikete, Caroline Froment, additional, Frosch, Matthew P., additional, Galasko, Douglas, additional, Garat, Oscar, additional, Giardinieri, Giulia, additional, Graff-Radford, Neill R., additional, Groot, Colin, additional, Hake, Ann Marie, additional, Hansson, Oskar, additional, Headley, Alison, additional, Hernandez, Micaela, additional, Hochberg, Daisy, additional, Hodges, John R., additional, Hof, Patrick R., additional, Holton, Janice, additional, Hromas, Gabrielle, additional, Illán Gala, Ignacio, additional, Jaunmuktane, Zane, additional, Jing, Donglai, additional, Kagerer, Sonja M., additional, Kasuga, Kensaku, additional, Kong, Yu, additional, Kövari, Enikö, additional, Lacombe-Thibault, Mégane, additional, Lleó Plarrumaní, Alberto, additional, Lucente, Diane E., additional, Machulda, Mary M., additional, Magnani, Giuseppe, additional, Magnin, Eloi, additional, Malpetti, Maura, additional, Matthews, Brandy, additional, McGinnis, Scott, additional, Mesulam, Marsel, additional, Miklitz, Carolin, additional, Mundada, Nidhi, additional, Nestor, Peter J., additional, Ocal, Dilek, additional, Paterson, Ross, additional, Piguet, Olivier, additional, Putcha, Deepti, additional, Quimby, Megan, additional, Reetz, Kathrin, additional, Rein, Netaniel, additional, Revesz, Tamas, additional, Rezaii, Neguine, additional, Rodriguez-Porcel, Federico, additional, Rowe, James B., additional, Ryan, Natalie, additional, Sanchez-Valle, Raquel, additional, Sacchi, Luca, additional, Santos-Santos, Miguel Ángel, additional, Sherman, Janet, additional, Stomrud, Erik, additional, Tideman, Pontus, additional, Tokutake, Takayoshi, additional, Tondo, Giacomo, additional, Touroutoglou, Alexandra, additional, Tousi, Babak, additional, Vandenberghe, Rik, additional, van der Flier, Wiesje, additional, Weintraub, Sandra, additional, Wong, Bonnie, additional, Wu, Liyong, additional, and Xie, Kexin, additional
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- 2024
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20. Biallelic COX10 Mutations and PMP22 Deletion in a Family With Leigh Syndrome and Hereditary Neuropathy With Liability to Pressure Palsy
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Kuroha, Yasuko, Ishiguro, Takanobu, Tada, Mari, Hara, Norikazu, Murayama, Kei, Kawachi, Izumi, Kasuga, Kensaku, Miyashita, Akinori, Hasegawa, Arika, Takahashi, Tetsuya, Matsubara, Nae, Onodera, Osamu, Kakita, Akiyoshi, Koike, Ryoko, and Ikeuchi, Takeshi
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- 2022
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21. Follow-up study of a patient with early onset cerebral amyloid angiopathy following childhood cadaveric dural graft
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Yoshiki, Kenji, Hirose, Genjiro, Kumahashi, Kazuhiko, Kohda, Yukihiko, Ido, Kazunori, Shioya, Akihiro, Misaki, Kouichi, and Kasuga, Kensaku
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- 2021
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22. Genetic characterization of NOTCH2NLC repeat expansion in patients with neuronal intranuclear inclusion disease (NIID)
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Fitrah, Yusran Ady, primary, Higuchi, Yo, additional, Hara, Norikazu, additional, Kasuga, Kensaku, additional, Miyashita, Akinori, additional, and Ikeuchi, Takeshi, additional
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- 2023
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23. Characteristics of cerebrospinal fluid biomarkers/imaging findings in ptaients with amyloid PET‐negative dementia
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Takenoshita, Naoto, primary, Yamamoto, Ryo, additional, Hanyu, Haruo, additional, Kasuga, Kensaku, additional, Ikeuchi, Takeshi, additional, Ishii, Kenji, additional, and Shimizu, Soichiro, additional
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- 2023
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24. AT(N) Classification and Clinical Characterization by CSF Biomarkers in Patients with Corticobasal Syndrome
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Ishiguro, Takanobu, primary, Kasuga, Kensaku, additional, Tokutake, Takayoshi, additional, Tsukie, Tamao, additional, Konno, Takuya, additional, Onodera, Osamu, additional, and Ikeuchi, Takeshi, additional
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- 2023
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25. Polygenic effects on the risk of Alzheimer′s disease in the Japanese population
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Kikuchi, Masataka, primary, Miyashita, Akinori, additional, Hara, Norikazu, additional, Kasuga, Kensaku, additional, Saito, Yuko, additional, Murayama, Shigeo, additional, Kakita, Akiyoshi, additional, Akatsu, Hiroyasu, additional, Ozaki, Kouichi, additional, Niida, Shumpei, additional, Kuwano, Ryozo, additional, Iwatsubo, Takeshi, additional, Nakaya, Akihiro, additional, and Ikeuchi, Takeshi, additional
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- 2023
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26. Switched Aβ43 generation in familial Alzheimer’s disease with presenilin 1 mutation
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Kakuda, Nobuto, Takami, Mako, Okochi, Masayasu, Kasuga, Kensaku, Ihara, Yasuo, and Ikeuchi, Takeshi
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- 2021
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27. Decrease in p3-Alcβ37 and p3-Alcβ40, products of Alcadein β generated by γ-secretase cleavages, in aged monkeys and patients with Alzheimer's disease
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Hata, Saori, Omori, Chiori, Kimura, Ayano, Saito, Haruka, Kimura, Nobuyuki, Gupta, Veer, Pedrini, Steve, Hone, Eugene, Chatterjee, Pratishtha, Taddei, Kevin, Kasuga, Kensaku, Ikeuchi, Takeshi, Waragai, Masaaki, Nishimura, Masaki, Hu, Anqi, Nakaya, Tadashi, Meijer, Laurent, Maeda, Masahiro, Yamamoto, Tohru, Masters, Colin L., Rowe, Chris C., Ames, David, Yamamoto, Kazuo, Martins, Ralph N., Gandy, Sam, and Suzuki, Toshiharu
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- 2019
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28. Identification and functional characterization of novel mutations including frameshift mutation in exon 4 of CSF1R in patients with adult-onset leukoencephalopathy with axonal spheroids and pigmented glia
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Miura, Takeshi, Mezaki, Naomi, Konno, Takuya, Iwasaki, Akio, Hara, Naoyuki, Miura, Masatomo, Funayama, Michitaka, Unai, Yuki, Tashiro, Yuichi, Okita, Kenji, Kihara, Takeshi, Ito, Nobuo, Kanatsuka, Yoichi, Jones, David T., Hara, Norikazu, Ishiguro, Takanobu, Tokutake, Takayoshi, Kasuga, Kensaku, Nozaki, Hiroaki, Dickson, Dennis W., Onodera, Osamu, Wszolek, Zbigniew K., and Ikeuchi, Takeshi
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- 2018
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29. Heterogenous Genetic, Clinical, and Imaging Features in Patients with Neuronal Intranuclear Inclusion Disease Carrying NOTCH2NLC Repeat Expansion
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Fitrah, Yusran Ady, primary, Higuchi, Yo, additional, Hara, Norikazu, additional, Tokutake, Takayoshi, additional, Kanazawa, Masato, additional, Sanpei, Kazuhiro, additional, Taneda, Tomone, additional, Nakajima, Akihiko, additional, Koide, Shin, additional, Tsuboguchi, Shintaro, additional, Watanabe, Midori, additional, Fukumoto, Junki, additional, Ando, Shoichiro, additional, Sato, Tomoe, additional, Iwafuchi, Yohei, additional, Sato, Aki, additional, Hayashi, Hideki, additional, Ishiguro, Takanobu, additional, Takeda, Hayato, additional, Takahashi, Toshiaki, additional, Fukuhara, Nobuyoshi, additional, Kasuga, Kensaku, additional, Miyashita, Akinori, additional, Onodera, Osamu, additional, and Ikeuchi, Takeshi, additional
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- 2023
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30. Duplication and deletion upstream of LMNB1 in autosomal dominant adult-onset leukodystrophy
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Mezaki, Naomi, Miura, Takeshi, Ogaki, Kotaro, Eriguchi, Makoto, Mizuno, Yuri, Komatsu, Kenichi, Yamazaki, Hiroki, Suetsugi, Natsuki, Kawajiri, Sumihiro, Yamasaki, Ryo, Ishiguro, Takanobu, Konno, Takuya, Nozaki, Hiroaki, Kasuga, Kensaku, Okuma, Yasuyuki, Kira, Jun-Ichi, Hara, Hideo, Onodera, Osamu, and Ikeuchi, Takeshi
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- 2018
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31. Soluble TREM2 in CSF and its association with other biomarkers and cognition in autosomal-dominant Alzheimer's disease: a longitudinal observational study
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Morenas-Rodríguez, Estrella, Li, Yan, Hassenstab, Jason, Laske, Christoph, Levey, Allan, Lopez, Oscar, Marsh, Jacob, Martinez, Rita, Martins, Ralph, Mason, Neal Scott, Masters, Colin, Mawuenyega, Kwasi, McCullough, Austin, McDade, Eric, Mejia, Arlene, MountzMD, James, Mummery, Cath, Nadkarni, Neelesh, Nagamatsu, Akemi, Neimeyer, Katie, Niimi, Yoshiki, Noble, James, Norton, Joanne, Nuscher, Brigitte, Feederle, Regina, O'Connor, Antoinette, Obermüller, Ulricke, Patira, Riddhi, Perrin, Richard, Ping, Lingyan, Preische, Oliver, Renton, Alan, Ringman, John, Salloway, Stephen, Schofield, Peter, Karch, Celeste M, Senda, Michio, Seyfried, Nick, Shady, Kristine, Shimada, Hiroyuki, Sigurdson, Wendy, Smith, Jennifer, Smith, Lori, Snitz, Beth, Sohrabi, Hamid, Stephens, Sochenda, Schlepckow, Kai, Taddei, Kevin, Thompson, Sarah, Wang, Peter, Wang, Qing, Weamer, Elise, Xu, Jinbin, Xu, Xiong, Morris, John C, Kleinberger, Gernot, Nellgard, Bengt, Vöglein, Jonathan, Blennow, Kaj, Zetterberg, Henrik, Ewers, Michael, Jucker, Mathias, Levin, Johannes, Bateman, Randall J, Haass, Christian, Network, Dominantly Inherited Alzheimer, Adams, Sarah, Allegri, Ricardo, Araki, Aki, Franzmeier, Nicolai, Barthelemy, Nicolas, Bechara, Jacob, Berman, Sarah, Bodge, Courtney, Brandon, Susan, Brooks, William Bill, Brosch, Jared, Buck, Jill, Buckles, Virginia, Carter, Kathleen, Xiong, Chengjie, Cash, Lisa, Chen, Charlie, Chhatwal, Jasmeer, Chrem, Patricio, Chua, Jasmin, Chui, Helena, Cruchaga, Carlos, Day, Gregory S, De La Cruz, Chrismary, Denner, Darcy, Suarez-Calvet, Marc, Diffenbacher, Anna, Dincer, Aylin, Donahue, Tamara, Douglas, Jane, Duong, Duc, Egido, Noelia, Esposito, Bianca, Farlow, Marty, Feldman, Becca, Fitzpatrick, Colleen, Fagan, Anne M, Flores, Shaney, Fox, Nick, Franklin, Erin, Friedrichsen, Nelly, Fujii, Hisako, Gardener, Samantha, Ghetti, Bernardino, Goate, Alison, Goldberg, Sarah, Goldman, Jill, Schultz, Stephanie, Gonzalez, Alyssa, Gräber-Sultan, Susanne, Graff-Radford, Neill, Graham, Morgan, Gray, Julia, Gremminger, Emily, Grilo, Miguel, Groves, Alex, Häsler, Lisa, Hellm, Cortaiga, Gordon, Brian A, Herries, Elizabeth, Hoechst-Swisher, Laura, Hofmann, Anna, Holtzman, David, Hornbeck, Russ, Igor, Yakushev, Ihara, Ryoko, Ikeuchi, Takeshi, Ikonomovic, Snezana, Ishii, Kenji, Benzinger, Tammie L S, Jack, Clifford, Jerome, Gina, Johnson, Erik, Kaeser, Stephan, Kasuga, Kensaku, Keefe, Sarah, Klunk, William Bill, Koeppe, Robert, Koudelis, Deb, and Kuder-Buletta, Elke
- Subjects
Adult ,Amyloid beta-Peptides ,Membrane Glycoproteins ,TREM2 protein, human ,physiology [Cognition] ,diagnostic imaging [Cognitive Dysfunction] ,genetics [Cognitive Dysfunction] ,genetics [Alzheimer Disease] ,Middle Aged ,United States ,Cognition ,genetics [Membrane Glycoproteins] ,Alzheimer Disease ,Humans ,genetics [Receptors, Immunologic] ,Cognitive Dysfunction ,ddc:610 ,Neurology (clinical) ,cerebrospinal fluid [Membrane Glycoproteins] ,Receptors, Immunologic ,diagnostic imaging [Alzheimer Disease] ,Biomarkers - Abstract
Therapeutic modulation of TREM2-dependent microglial function might provide an additional strategy to slow the progression of Alzheimer's disease. Although studies in animal models suggest that TREM2 is protective against Alzheimer's pathology, its effect on tau pathology and its potential beneficial role in people with Alzheimer's disease is still unclear. Our aim was to study associations between the dynamics of soluble TREM2, as a biomarker of TREM2 signalling, and amyloid β (Aβ) deposition, tau-related pathology, neuroimaging markers, and cognitive decline, during the progression of autosomal dominant Alzheimer's disease.We did a longitudinal analysis of data from the Dominantly Inherited Alzheimer Network (DIAN) observational study, which includes families with a history of autosomal dominant Alzheimer's disease. Participants aged over 18 years who were enrolled in DIAN between Jan 1, 2009, and July 31, 2019, were categorised as either carriers of pathogenic variants in PSEN1, PSEN2, and APP genes (n=155) or non-carriers (n=93). We measured amounts of cleaved soluble TREM2 using a novel immunoassay in CSF samples obtained every 2 years from participants who were asymptomatic (Clinical Dementia Rating [CDR]=0) and annually for those who were symptomatic (CDR>0). CSF concentrations of Aβ40, Aβ42, total tau (t-tau), and tau phosphorylated on threonine 181 (p-tau) were measured by validated immunoassays. Predefined neuroimaging measurements were total cortical uptake of Pittsburgh compound B PET (PiB-PET), cortical thickness in the precuneus ascertained by MRI, and hippocampal volume determined by MRI. Cognition was measured using a validated cognitive composite (including DIAN word list test, logical memory delayed recall, digit symbol coding test [total score], and minimental status examination). We based our statistical analysis on univariate and bivariate linear mixed effects models.In carriers of pathogenic variants, a high amyloid burden at baseline, represented by low CSF Aβ42 (β=-4·28 × 10-2 [SE 0·013], p=0·0012), but not high cortical uptake in PiB-PET (β=-5·51 × 10-3 [0·011], p=0·63), was the only predictor of an augmented annual rate of subsequent increase in soluble TREM2. Augmented annual rates of increase in soluble TREM2 were associated with a diminished rate of decrease in amyloid deposition, as measured by Aβ42 in CSF (r=0·56 [0·22], p=0·011), in presymptomatic carriers of pathogenic variants, and with diminished annual rate of increase in PiB-PET (r=-0·67 [0·25], p=0·0060) in symptomatic carriers of pathogenic variants. Presymptomatic carriers of pathogenic variants with annual rates of increase in soluble TREM2 lower than the median showed a correlation between enhanced annual rates of increase in p-tau in CSF and augmented annual rates of increase in PiB-PET signal (r=0·45 [0·21], p=0·035), that was not observed in those with rates of increase in soluble TREM2 higher than the median. Furthermore, presymptomatic carriers of pathogenic variants with rates of increase in soluble TREM2 above or below the median had opposite associations between Aβ42 in CSF and PiB-PET uptake when assessed longitudinally. Augmented annual rates of increase in soluble TREM2 in presymptomatic carriers of pathogenic variants correlated with decreased cortical shrinkage in the precuneus (r=0·46 [0·22]), p=0·040) and diminished cognitive decline (r=0·67 [0·22], p=0·0020).Our findings in autosomal dominant Alzheimer's disease position the TREM2 response within the amyloid cascade immediately after the first pathological changes in Aβ aggregation and further support the role of TREM2 on Aβ plaque deposition and compaction. Furthermore, these findings underpin a beneficial effect of TREM2 on Aβ deposition, Aβ-dependent tau pathology, cortical shrinkage, and cognitive decline. Soluble TREM2 could, therefore, be a key marker for clinical trial design and interpretation. Efforts to develop TREM2-boosting therapies are ongoing.German Research Foundation, US National Institutes of Health.
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- 2022
32. Brain p3‐Alcβ peptide restores neuronal viability impaired by Alzheimer's amyloid β‐peptide
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Hata, Saori, primary, Saito, Haruka, additional, Kakiuchi, Takeharu, additional, Fukumoto, Dai, additional, Yamamoto, Shigeyuki, additional, Kasuga, Kensaku, additional, Kimura, Ayano, additional, Moteki, Koichi, additional, Abe, Ruriko, additional, Adachi, Shungo, additional, Kinoshita, Shoich, additional, Yoshizawa‐Kumagaye, Kumiko, additional, Nishio, Hideki, additional, Saito, Takashi, additional, Saido, Takaomi C, additional, Yamamoto, Tohru, additional, Nishimura, Masaki, additional, Taru, Hidenori, additional, Sobu, Yuriko, additional, Ohba, Hiroyuki, additional, Nishiyama, Shingo, additional, Harada, Norihiro, additional, Ikeuchi, Takeshi, additional, Tsukada, Hideo, additional, Ouchi, Yasuomi, additional, and Suzuki, Toshiharu, additional
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- 2023
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33. Novel Partial Deletions, Frameshift and Missense Mutations ofCSF1Rin Patents withCSF1R ‐RelatedLeukoencephalopathy
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Ishiguro, Takanobu, primary, Konno, Takuya, additional, Hara, Norikazu, additional, Zhu, Bin, additional, Okada, Satoshi, additional, Shibata, Mamoru, additional, Saika, Reiko, additional, Kitano, Takaya, additional, Toko, Megumi, additional, Nezu, Tomohisa, additional, Hama, Yuka, additional, Kawazoe, Tomoya, additional, Takahashi‐Iwata, Ikuko, additional, Yabe, Ichiro, additional, Sato, Kota, additional, Takeda, Hayato, additional, Toda, Shintaro, additional, Nishimiya, Jin, additional, Teduka, Toshiyuki, additional, Nozaki, Hiroaki, additional, Kasuga, Kensaku, additional, Miyashita, Akinori, additional, Onodera, Osamu, additional, and Ikeuchi, Takeshi, additional
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- 2023
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34. Urinary proteome profiles associated with cognitive decline in community elderly residents—A pilot study
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Watanabe, Yumi, primary, Hirao, Yoshitoshi, additional, Kasuga, Kensaku, additional, Kitamura, Kaori, additional, Nakamura, Kazutoshi, additional, and Yamamoto, Tadashi, additional
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- 2023
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35. Comparison of amyloid burden in individuals with Down syndrome versus autosomal dominant Alzheimer's disease: a cross-sectional study
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Boerwinkle, Anna H, primary, Gordon, Brian A, additional, Wisch, Julie, additional, Flores, Shaney, additional, Henson, Rachel L, additional, Butt, Omar H, additional, McKay, Nicole, additional, Chen, Charles D, additional, Benzinger, Tammie L S, additional, Fagan, Anne M, additional, Handen, Benjamin L, additional, Christian, Bradley T, additional, Head, Elizabeth, additional, Mapstone, Mark, additional, Rafii, Michael S, additional, O'Bryant, Sid, additional, Lai, Florence, additional, Rosas, H Diana, additional, Lee, Joseph H, additional, Silverman, Wayne, additional, Brickman, Adam M, additional, Chhatwal, Jasmeer P, additional, Cruchaga, Carlos, additional, Perrin, Richard J, additional, Xiong, Chengjie, additional, Hassenstab, Jason, additional, McDade, Eric, additional, Bateman, Randall J, additional, Ances, Beau M, additional, Aizenstein, Howard J, additional, Andrews, Howard F, additional, Bell, Karen, additional, Birn, Rasmus M, additional, Bulova, Peter, additional, Cheema, Amrita, additional, Chen, Kewei, additional, Clare, Isabel, additional, Clark, Lorraine, additional, Cohen, Ann D, additional, Constantino, John N, additional, Doran, Eric W, additional, Feingold, Eleanor, additional, Foroud, Tatiana M, additional, Hartley, Sigan L, additional, Hom, Christy, additional, Honig, Lawrence, additional, Ikonomovic, Milos D, additional, Johnson, Sterling C, additional, Jordan, Courtney, additional, Kamboh, M Ilyas, additional, Keator, David, additional, Klunk MD, William E, additional, Kofler, Julia K, additional, Kreisl, William C, additional, Krinsky- McHale, Sharon J, additional, Lao, Patrick, additional, Laymon, Charles, additional, Lott, Ira T, additional, Lupson, Victoria, additional, Mathis, Chester A, additional, Minhas, Davneet S, additional, Nadkarni, Neelesh, additional, Pang, Deborah, additional, Petersen, Melissa, additional, Price, Julie C, additional, Pulsifer, Margaret, additional, Reiman, Eric, additional, Rizvi, Batool, additional, Sabbagh, Marwan N, additional, Schupf, Nicole, additional, Tudorascu, Dana L, additional, Tumuluru, Rameshwari, additional, Tycko, Benjamin, additional, Varadarajan, Badri, additional, White, Desiree A, additional, Yassa, Michael A, additional, Zaman, Shahid, additional, Zhang, Fan, additional, Adams, Sarah, additional, Allegri, Ricardo, additional, Araki, Aki, additional, Barthelemy, Nicolas, additional, Bechara, Jacob, additional, Berman, Sarah, additional, Bodge, Courtney, additional, Brandon, Susan, additional, Brooks, William, additional, Brosch, Jared, additional, Buck, Jill, additional, Buckles, Virginia, additional, Carter, Kathleen, additional, Cash, Lisa, additional, Mendez, Patricio C, additional, Chua, Jasmin, additional, Chui, Helena, additional, Courtney, Laura, additional, Day, Gregory, additional, DeLaCruz, Chrismary, additional, Denner, Darcy, additional, Diffenbacher, Anna, additional, Dincer, Aylin, additional, Donahue, Tamara, additional, Douglas, Jane, additional, Duong, Duc, additional, Egido, Noelia, additional, Esposito, Bianca, additional, Farlow, Marty, additional, Feldman, Becca, additional, Fitzpatrick, Colleen, additional, Fox, Nick, additional, Franklin, Erin, additional, Joseph-Mathurin, Nelly, additional, Fujii, Hisako, additional, Gardener, Samantha, additional, Ghetti, Bernardino, additional, Goate, Alison, additional, Goldberg, Sarah, additional, Goldman, Jill, additional, Gonzalez, Alyssa, additional, Gräber-Sultan, Susanne, additional, Graff-Radford, Neill, additional, Graham, Morgan, additional, Gray, Julia, additional, Gremminger, Emily, additional, Grilo, Miguel, additional, Groves, Alex, additional, Haass, Christian, additional, Häslerc, Lisa, additional, Hellm, Cortaiga, additional, Herries, Elizabeth, additional, Hoechst-Swisher, Laura, additional, Hofmann, Anna, additional, Holtzman, David, additional, Hornbeck, Russ, additional, Igor, Yakushev, additional, Ihara, Ryoko, additional, Ikeuchi, Takeshi, additional, Ikonomovic, Snezana, additional, Ishii, Kenji, additional, Jack, Clifford, additional, Jerome, Gina, additional, Johnson, Erik, additional, Jucker, Mathias, additional, Karch, Celeste, additional, Käser, Stephan, additional, Kasuga, Kensaku, additional, Keefe, Sarah, additional, Klunk, William, additional, Koeppe, Robert, additional, Koudelis, Deb, additional, Kuder-Buletta, Elke, additional, Laske, Christoph, additional, Levey, Allan, additional, Levin, Johannes, additional, Li, Yan, additional, Lopez, Oscar, additional, Marsh, Jacob, additional, Martins, Ralph, additional, Mason, Neal S, additional, Masters, Colin, additional, Mawuenyega, Kwasi, additional, McCullough, Austin, additional, Mejia, Arlene, additional, Morenas-Rodriguez, Estrella, additional, Morris, John C, additional, Mountz, James, additional, Mummery, Catherine, additional, Nagamatsu, Akemi, additional, Neimeyer, Katie, additional, Niimi, Yoshiki, additional, Noble, James, additional, Norton, Joanne, additional, Nuscher, Brigitte, additional, Obermüller, Ulricke, additional, O'Connor, Antoinette, additional, Patira, Riddhi, additional, Ping, Lingyan, additional, Preische, Oliver, additional, Renton, Alan, additional, Ringman, John, additional, Salloway, Stephen, additional, Schofield, Peter, additional, Senda, Michio, additional, Seyfried, Nicholas T, additional, Shady, Kristine, additional, Shimada, Hiroyuki, additional, Sigurdson, Wendy, additional, Smith, Jennifer, additional, Smith, Lori, additional, Snitz, Beth, additional, Sohrabi, Hamid, additional, Stephens, Sochenda, additional, Taddei, Kevin, additional, Thompson, Sarah, additional, Vöglein, Jonathan, additional, Wang, Peter, additional, Wang, Qing, additional, Weamer, Elise, additional, Xu, Jinbin, additional, and Xu, Xiong, additional
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- 2023
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36. Change in cerebrospinal fluid tau microtubule binding region detects symptom onset, cognitive decline, tangles, and atrophy in Dominantly Inherited Alzheimer's Disease
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Horie, Kanta, Li, Yan, Allegri, Ricardo, Mendez, Patricio Chrem, Ikeuchi, Takeshi, Kasuga, Kensaku, Noble, James, Farlow, Martin, Chhatwal, Jasmeer, Day, Gregory S, Schofield, Peter R, Masters, Colin L, Barthélemy, Nicolas R, Levin, Johannes, Jucker, Mathias, Lee, Jae-Hong, Roh, Jee Hoon, Sato, Chihiro, Sachdev, Pallavi, Koyama, Akihiko, Reyderman, Larisa, Bateman, Randall J, McDade, Eric, Gordon, Brian A, Network, Dominantly Inherited Alzheimer, Hassenstab, Jason, Benzinger, Tammie L S, Fagan, Anne M, Morris, John C, Karch, Celeste M, and Xiong, Chengjie
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Neurology ,Neurology (clinical) ,ddc:610 - Abstract
Identifying cerebrospinal fluid measures of the microtubule binding region of tau (MTBR-tau) species that reflect tau aggregation could provide fluid biomarkers that track Alzheimer disease related neurofibrillary tau pathological changes. We examined CSF MTBR-tau species in dominantly inherited Alzheimer disease (DIAD) mutation carriers to assess the association with AD biomarkers and clinical symptoms.Cross-sectional and longitudinal CSF from 229 DIAD mutation and 130 mutation non-carriers had sequential characterization of N-terminal/mid-domain phosphorylated tau (p-tau) followed by MTBR-tau species and tau-PET, other soluble tau and amyloid biomarkers, comprehensive clinical and cognitive assessments, and brain magnetic resonance imaging of atrophy.CSF MTBR-tau species located within the putative 'border' region and one species corresponding to the 'core' region of aggregates in neurofibrillary tangles increased during the presymptomatic stage and decreased during the symptomatic stage. The 'border' MTBR-tau species were associated with amyloid pathology and CSF p-tau; while the 'core' MTBR-tau species were associated stronger with tau-PET and CSF measures of neurodegeneration. The ratio of the border to the core species provided a continuous measure of increasing amounts that tracked clinical progression and NFT.Changes in CSF soluble MTBR-tau species preceded the onset of dementia, tau tangle increase, and atrophy in DIAD. The ratio of 4R-specific MTBR-tau (border) to the NFT (core) MTBR-tau species corresponds to the pathology of NFT in DIAD and change with disease progression. The dynamics between different MTBR-tau species in the CSF may serve as a marker of tau-related disease progression and target engagement of anti-tau therapeutics. This article is protected by copyright. All rights reserved.
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- 2023
37. Decreased circulating branched-chain amino acids are associated with development of Alzheimer’s disease in elderly individuals with mild cognitive impairment
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Ikeuchi, Takeshi, primary, Kanda, Mayuka, additional, Kitamura, Hitomi, additional, Morikawa, Fumiyoshi, additional, Toru, Shuta, additional, Nishimura, Chika, additional, Kasuga, Kensaku, additional, Tokutake, Takayoshi, additional, Takahashi, Tetsuya, additional, Kuroha, Yasuko, additional, Miyazawa, Nobuhiko, additional, Tanaka, Shin, additional, Utsumi, Kumiko, additional, Ono, Kenjiro, additional, Yano, Satoshi, additional, Hamano, Tadanori, additional, Naruse, Satoshi, additional, Yajima, Ryuji, additional, Kawashima, Noriko, additional, Kaneko, Chikako, additional, Tachibana, Hisatsugu, additional, Yano, Yuki, additional, Kato, Yumiko, additional, Toue, Sakino, additional, Jinzu, Hiroko, additional, Kitamura, Akihiko, additional, Yokoyama, Yuri, additional, Kaneko, Eiji, additional, Yamakado, Minoru, additional, and Nagao, Kenji, additional
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- 2022
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38. Estimation of blood-based biomarkers of glial activation related to neuroinflammation
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Yasuno, Fumihiko, primary, Watanabe, Atsushi, additional, Kimura, Yasuyuki, additional, Yamauchi, Yumeka, additional, Ogata, Aya, additional, Ikenuma, Hiroshi, additional, Abe, Junichiro, additional, Minami, Hiroyuki, additional, Nihashi, Takashi, additional, Yokoi, Kastunori, additional, Hattori, Saori, additional, Shimoda, Nobuyoshi, additional, Kasuga, Kensaku, additional, Ikeuchi, Takeshi, additional, Takeda, Akinori, additional, Sakurai, Takashi, additional, Ito, Kengo, additional, and Kato, Takashi, additional
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- 2022
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39. Biomarkers and neuropathology in posterior cortical atrophy: an international, multi‐site study
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Chapleau, Marianne, primary, La Joie, Renaud, additional, Mundada, Nidhi S., additional, Fumagalli, Giorgio G, additional, Formaglio, Maïté, additional, Grinberg, Lea Tenenholz, additional, Hromas, Gabrielle, additional, Kasuga, Kensaku, additional, Lacombe‐Thibault, Mégane, additional, Levin, Netta, additional, Lladó, Albert, additional, Miklitz, Carolin, additional, Perani, Daniela, additional, Rodriguez‐Porcel, Federico, additional, Seeley, William W., additional, Spina, Salvatore, additional, Tousi, Babak, additional, Vandenberghe, Rik, additional, Walker, Jamie M., additional, Wu, Liyong, additional, Yong, Keir X X, additional, Pelak, Victoria S, additional, Ossenkoppele, Rik, additional, and Rabinovici, Gil D., additional
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- 2022
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40. Current and Future Trends in Biomarkers for the Early Detection of Alzheimer’s Disease in Asia: Expert Opinion
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Kandiah, Nagaendran, primary, Choi, Seong Hye, additional, Hu, Chaur-Jong, additional, Ishii, Kenji, additional, Kasuga, Kensaku, additional, and Mok, Vincent C.T., additional
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- 2022
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41. Involvement of inflammation in the medial temporal region in the development of agitation in Alzheimer's disease: an in vivo positron emission tomography study
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Yasuno, Fumihiko, primary, Kimura, Yasuyuki, additional, Ogata, Aya, additional, Ikenuma, Hiroshi, additional, Abe, Junichiro, additional, Minami, Hiroyuki, additional, Nihashi, Takashi, additional, Yokoi, Kastunori, additional, Hattori, Saori, additional, Shimoda, Nobuyoshi, additional, Watanabe, Atsushi, additional, Kasuga, Kensaku, additional, Ikeuchi, Takeshi, additional, Takeda, Akinori, additional, Sakurai, Takashi, additional, Ito, Kengo, additional, and Kato, Takashi, additional
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- 2022
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42. The Clinical Application of Optimized AT(N) Classification in Alzheimer’s Clinical Syndrome (ACS) and non-ACS Conditions
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Kasuga, Kensaku, primary, Tsukie, Tamao, additional, Kikuchi, Masataka, additional, Tokutake, Takayoshi, additional, Washiyama, Kazuo, additional, Simizu, Soichiro, additional, Yoshizawa, Hiroshi, additional, Kuroha, Yasuko, additional, Yajima, Ryuji, additional, Mori, Hiroshi, additional, Arakawa, Yasuaki, additional, Onda, Kiyoshi, additional, Miyashita, Akinori, additional, Onodera, Osamu, additional, Iwatsubo, Takeshi, additional, and Ikeuchi, Takeshi, additional
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- 2022
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43. Different AT(N) profiles and clinical progression classified by two different N markers using total tau and neurofilament light chain in cerebrospinal fluid
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Kasuga, Kensaku, primary, Kikuchi, Masataka, additional, Tsukie, Tamao, additional, Suzuki, Kazushi, additional, Ihara, Ryoko, additional, Iwata, Atsushi, additional, Hara, Norikazu, additional, Miyashita, Akinori, additional, Kuwano, Ryozo, additional, Iwatsubo, Takeshi, additional, and Ikeuchi, Takeshi, additional
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- 2022
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44. Predicting brain age from functional connectivity in symptomatic and preclinical Alzheimer disease
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Millar, Peter R., primary, Luckett, Patrick H., additional, Gordon, Brian A., additional, Benzinger, Tammie L.S., additional, Schindler, Suzanne E., additional, Fagan, Anne M., additional, Cruchaga, Carlos, additional, Bateman, Randall J., additional, Allegri, Ricardo, additional, Jucker, Mathias, additional, Lee, Jae-Hong, additional, Mori, Hiroshi, additional, Salloway, Stephen P, additional, Yakushev, Igor, additional, Morris, John C., additional, Ances, Beau M., additional, Adams, Sarah, additional, Araki, Aki, additional, Barthelemy, Nicolas, additional, Bateman, Randall, additional, Bechara, Jacob, additional, Benzinger, Tammie, additional, Berman, Sarah, additional, Bodge, Courtney, additional, Brandon, Susan, additional, Brooks, William (Bill), additional, Brosch, Jared, additional, Buck, Jill, additional, Buckles, Virginia, additional, Carter, Kathleen, additional, Cash, Lisa, additional, Chen, Charlie, additional, Chhatwal, Jasmeer, additional, Mendez, Patricio Chrem, additional, Chua, Jasmin, additional, Chui, Helena, additional, Courtney, Laura, additional, Day, Gregory S, additional, DeLaCruz, Chrismary, additional, Denner, Darcy, additional, Diffenbacher, Anna, additional, Dincer, Aylin, additional, Donahue, Tamara, additional, Douglas, Jane, additional, Duong, Duc, additional, Egido, Noelia, additional, Esposito, Bianca, additional, Fagan, Anne, additional, Farlow, Marty, additional, Feldman, Becca, additional, Fitzpatrick, Colleen, additional, Flores, Shaney, additional, Fox, Nick, additional, Franklin, Erin, additional, Joseph-Mathurin, Nelly, additional, Fujii, Hisako, additional, Gardener, Samantha, additional, Ghetti, Bernardino, additional, Goate, Alison, additional, Goldberg, Sarah, additional, Goldman, Jill, additional, Gonzalez, Alyssa, additional, Gordon, Brian, additional, Gräber-Sultan, Susanne, additional, Graff-Radford, Neill, additional, Graham, Morgan, additional, Gray, Julia, additional, Gremminger, Emily, additional, Grilo, Miguel, additional, Groves, Alex, additional, Haass, Christian, additional, Häsler, Lisa, additional, Hassenstab, Jason, additional, Hellm, Cortaiga, additional, Herries, Elizabeth, additional, Hoechst-Swisher, Laura, additional, Hofmann, Anna, additional, Holtzman, David, additional, Hornbeck, Russ, additional, Igor, Yakushev, additional, Ihara, Ryoko, additional, Ikeuchi, Takeshi, additional, Ikonomovic, Snezana, additional, Ishii, Kenji, additional, Jack, Clifford, additional, Jerome, Gina, additional, Johnson, Erik, additional, Karch, Celeste, additional, Käser, Stephan, additional, Kasuga, Kensaku, additional, Keefe, Sarah, additional, Klunk, William, additional, Koeppe, Robert, additional, Koudelis, Deb, additional, Kuder-Buletta, Elke, additional, Laske, Christoph, additional, Levey, Allan, additional, Levin, Johannes, additional, Li, Yan, additional, Lopez, Oscar, additional, Marsh, Jacob, additional, Martins, Ralph, additional, Mason, Neal Scott, additional, Masters, Colin, additional, Mawuenyega, Kwasi, additional, McCullough, Austin, additional, McDade, Eric, additional, Mejia, Arlene, additional, Morenas-Rodriguez, Estrella, additional, Morris, John, additional, Mountz, James, additional, Mummery, Cath, additional, Nadkarni, N eelesh, additional, Nagamatsu, Akemi, additional, Neimeyer, Katie, additional, Niimi, Yoshiki, additional, Noble, James, additional, Norton, Joanne, additional, Nuscher, Brigitte, additional, Obermüller, Ulricke, additional, O'Connor, Antoinette, additional, Patira, Riddhi, additional, Perrin, Richard, additional, Ping, Lingyan, additional, Preische, Oliver, additional, Renton, Alan, additional, Ringman, John, additional, Salloway, Stephen, additional, Schofield, Peter, additional, Senda, Michio, additional, Seyfried, Nicholas T, additional, Shady, Kristine, additional, Shimada, Hiroyuki, additional, Sigurdson, Wendy, additional, Smith, Jennifer, additional, Smith, Lori, additional, Snitz, Beth, additional, Sohrabi, Hamid, additional, Stephens, Sochenda, additional, Taddei, Kevin, additional, Thompson, Sarah, additional, Vöglein, Jonathan, additional, Wang, Peter, additional, Wang, Qing, additional, Weamer, Elise, additional, Xiong, Chengjie, additional, Xu, Jinbin, additional, and Xu, Xiong, additional
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- 2022
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45. Generation of a gene-corrected human isogenic iPSC line from an Alzheimer’s disease iPSC line carrying the PSEN1 H163R mutation
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Adams, Sarah, Allegri, Ricardo, Araki, Aki, Barthelemy, Nicolas, Bateman, Randall, Bechara, Jacob, Benzinger, Tammie, Berman, Sarah, Bodge, Courtney, Brandon, Sus, (Bill) Brooks, William, Brosch, Jared, Buck, Jill, Buckles, Virginia, Carter, Kathleen, Cash, Lisa, Chen, Charlie, Chhatwal, Jasmeer, Chrem Mendez, Patricio, Chua, Jasmin, Chui, Helena, Courtney, Laura, Cruchaga, Carlos, Day, Gregory S, DeLaCruz, Chrismary, Denner, Darcy, Diffenbacher, Anna, Dincer, Aylin, Donahue, Tamara, Douglas, Jane, Duong, Duc, Egido, Noelia, Esposito, Bianca, Fagan, Anne, Farlow, Marty, Feldman, Becca, Fitzpatrick, Colleen, Flores, Shaney, Fox, Nick, Franklin, Erin, Joseph-Mathurin, Nelly, Fujii, Hisako, Gardener, Samantha, Ghetti, Bernardino, Goate, Alison, Goldberg, Sarah, Goldman, Jill, Gonzalez, Alyssa, Gordon, Brian, Gr¨aber-Sultan, Susanne, Graff-Radford, Neill, Graham, Morgan, Gray, Julia, Gremminger, Emily, Grilo, Miguel, Groves, Alex, Haass, Christian, H¨asler, Lisa, Hassenstab, Jason, Hellm, Cortaiga, Herries, Elizabeth, Hoechst-Swisher, Laura, Hofmann, Anna, Holtzman, David, Hornbeck, Russ, Igor, Yakushev, Ihara, Ryoko, Ikeuchi, Takeshi, Ikonomovic, Snezana, Ishii, Kenji, Jack, Clifford, Jerome, Gina, Johnson, Erik, Jucker, Mathias, Karch, Celeste, K¨aser, Stephan, Kasuga, Kensaku, Keefe, Sarah, Klunk, William, Koeppe, Robert, Koudelis, Deb, Kuder-Buletta, Elke, Laske, Christoph, Levey, Allan, Levin, Johannes, Li, Yan, Lopez, Oscar, Marsh, Jacob, Martins, Ralph, Scott Mason, Neal, Masters, Colin, Mawuenyega, Kwasi, McCullough, Austin, McDade, Eric, Mejia, Arlene, Morenas-Rodriguez, Estrella, Morris, John, Mountz, James, Mummery, Cath, Nadkarni, Neelesh, Nagamatsu, Akemi, Neimeyer, Katie, Niimi, Yoshiki, Noble, James, Norton, Joanne, Nuscher, Brigitte, Obermüller, Ulricke, O’Connor, Antoinette, Patira, Riddhi, Perrin, Richard, Ping, Lingyan, Preische, Oliver, Renton, Alan, Ringman, John, Salloway, Stephen, Schofield, Peter, Senda, Michio, Seyfried, Nicholas T, Shady, Kristine, Shimada, Hiroyuki, Sigurdson, Wendy, Smith, Jennifer, Smith, Lori, Snitz, Beth, Sohrabi, Hamid, Stephens, Sochenda, Taddei, Kevin, Thompson, Sarah, V¨oglein, Jonathan, Wang, Peter, Wang, Qing, Weamer, Elise, Xiong, Chengjie, Xu, Jinbin, Xu, Xiong, Hernández, Damián, Morgan Schlicht, Stephanie, Elli Clarke, Jordan, Daniszewski, Maciej, Karch, Celeste M., Goate, Alison M., and Pébay, Alice
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- 2024
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46. Predicting brain age from functional connectivity in symptomatic and preclinical Alzheimer disease
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Millar, Peter R, Luckett, Patrick H, Lee, Jaehyun, Laske, Christoph, Levey, Allan, Levin, Johannes, Li, Yan, Lopez, Oscar, Marsh, Jacob, Martins, Ralph, Mason, Neal Scott, Masters, Colin, Mawuenyega, Kwasi, Mori, Hiroshi, McCullough, Austin, McDade, Eric, Mejia, Arlene, Morenas Rodriguez, Estrella, Morris, John, Mountz, James, Mummery, Cath, Nadkarni, N Eelesh, Nagamatsu, Akemi, Neimeyer, Katie, Salloway, Stephen P, Niimi, Yoshiki, Noble, James, Norton, Joanne, Nuscher, Brigitte, Obermüller, Ulricke, O'Connor, Antoinette, Patira, Riddhi, Perrin, Richard, Ping, Lingyan, Preische, Oliver, Yakushev, Igor, Renton, Alan, Ringman, John, Salloway, Stephen, Schofield, Peter, Senda, Michio, Seyfried, Nicholas T, Shady, Kristine, Shimada, Hiroyuki, Sigurdson, Wendy, Smith, Jennifer, Morris, John C, Smith, Lori, Snitz, Beth, Sohrabi, Hamid, Stephens, Sochenda, Taddei, Kevin, Thompson, Sarah, Vöglein, Jonathan, Wang, Peter, Wang, Qing, Weamer, Elise, Ances, Beau M, Xiong, Chengjie, Xu, Jinbin, Xu, Xiong, Network, Dominantly Inherited Alzheimer, Adams, Sarah, Allegri, Ricardo, Araki, Aki, Gordon, Brian A, Barthelemy, Nicolas, Bateman, Randall, Bechara, Jacob, Benzinger, Tammie, Berman, Sarah, Bodge, Courtney, Brandon, Susan, Brooks, William Bill, Brosch, Jared, Buck, Jill, Benzinger, Tammie L S, Buckles, Virginia, Carter, Kathleen, Cash, Lisa, Chen, Charlie, Chhatwal, Jasmeer, Mendez, Patricio Chrem, Chua, Jasmin, Chui, Helena, Courtney, Laura, Cruchaga, Carlos, Schindler, Suzanne E, Day, Gregory S, DeLaCruz, Chrismary, Denner, Darcy, Diffenbacher, Anna, Dincer, Aylin, Donahue, Tamara, Douglas, Jane, Duong, Duc, Egido, Noelia, Esposito, Bianca, Fagan, Anne M, Fagan, Anne, Farlow, Marty, Feldman, Becca, Fitzpatrick, Colleen, Flores, Shaney, Fox, Nick, Franklin, Erin, Joseph-Mathurin, Nelly, Fujii, Hisako, Gardener, Samantha, Ghetti, Bernardino, Goate, Alison, Goldberg, Sarah, Goldman, Jill, Gonzalez, Alyssa, Gordon, Brian, Gräber-Sultan, Susanne, Graff-Radford, Neill, Graham, Morgan, Gray, Julia, Bateman, Randall J, Gremminger, Emily, Grilo, Miguel, Groves, Alex, Haass, Christian, Häsler, Lisa, Hassenstab, Jason, Hellm, Cortaiga, Herries, Elizabeth, Hoechst-Swisher, Laura, Hofmann, Anna, Holtzman, David, Hornbeck, Russ, Igor, Yakushev, Ihara, Ryoko, Ikeuchi, Takeshi, Ikonomovic, Snezana, Ishii, Kenji, Jack, Clifford, Jerome, Gina, Jucker, Mathias, Johnson, Erik, Karch, Celeste, Kaeser, Stephan, Kasuga, Kensaku, Keefe, Sarah, Klunk, William, Koeppe, Robert, Koudelis, Deb, and Kuder-Buletta, Elke
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Adult ,Aged, 80 and over ,Adolescent ,Resting-state functional connectivity ,Cognitive Neuroscience ,fMRI ,Brain ,Neuroimaging ,Middle Aged ,Magnetic Resonance Imaging ,pathology [Alzheimer Disease] ,Young Adult ,physiology [Brain] ,methods [Magnetic Resonance Imaging] ,Neurology ,Brain aging ,Alzheimer Disease ,Machine learning ,Humans ,ddc:610 ,Alzheimer disease ,Biomarkers ,Aged - Abstract
"Brain-predicted age" quantifies apparent brain age compared to normative neuroimaging trajectories. Advanced brain-predicted age has been well established in symptomatic Alzheimer disease (AD), but is underexplored in preclinical AD. Prior brain-predicted age studies have typically used structural MRI, but resting-state functional connectivity (FC) remains underexplored. Our model predicted age from FC in 391 cognitively normal, amyloid-negative controls (ages 18-89). We applied the trained model to 145 amyloid-negative, 151 preclinical AD, and 156 symptomatic AD participants to test group differences. The model accurately predicted age in the training set. FC-predicted brain age gaps (FC-BAG) were significantly older in symptomatic AD and significantly younger in preclinical AD compared to controls. There was minimal correspondence between networks predictive of age and AD. Elevated FC-BAG may reflect network disruption during symptomatic AD. Reduced FC-BAG in preclinical AD was opposite to the expected direction, and may reflect a biphasic response to preclinical AD pathology or may be driven by inconsistency between age-related vs. AD-related networks. Overall, FC-predicted brain age may be a sensitive AD biomarker.
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- 2022
47. Involvement of inflammation in the medial temporal region in the development of agitation in Alzheimer's disease: an in vivo positron emission tomography study.
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Yasuno, Fumihiko, Kimura, Yasuyuki, Ogata, Aya, Ikenuma, Hiroshi, Abe, Junichiro, Minami, Hiroyuki, Nihashi, Takashi, Yokoi, Kastunori, Hattori, Saori, Shimoda, Nobuyoshi, Watanabe, Atsushi, Kasuga, Kensaku, Ikeuchi, Takeshi, Takeda, Akinori, Sakurai, Takashi, Ito, Kengo, and Kato, Takashi
- Subjects
RESEARCH ,TEMPORAL lobe ,ALZHEIMER'S disease ,IN vivo studies ,HIPPOCAMPUS (Brain) ,INFLAMMATION ,AGITATION (Psychology) ,AMYLOID beta-protein precursor ,NEUROINFLAMMATION ,COMPARATIVE studies ,NEUROPSYCHOLOGICAL tests ,POSITRON emission tomography ,DESCRIPTIVE statistics ,DEMENTIA ,DISEASE duration ,QUESTIONNAIRES ,STATISTICAL correlation ,COMPUTED tomography ,ALTERNATIVE medicine ,SOCIODEMOGRAPHIC factors ,CEREBROSPINAL fluid ,MENTAL illness ,DISEASE complications - Abstract
Background: The evaluation of 11C‐DPA‐713 binding using positron emission tomography for quantifying the translocator protein can be a sensitive approach in determining the level of glial activation induced by neuroinflammation. Herein, we aimed to investigate the relationship between regional 11C‐DPA713‐binding potential (BPND) and neuropsychiatric symptoms (NPS) in amyloid‐positive Alzheimer's disease (AD) patients. Methods: Fifteen AD patients were enrolled in this study. Correlations were evaluated between the 11C‐DPA713‐BPND and Neuropsychiatric Inventory Questionnaire (NPI‐Q) scores, including scores in its four domains: agitation, psychosis, affective, and apathy. 11C‐DPA713‐BPND values were compared between groups with and without the neuropsychiatric symptoms for which a relationship was observed in the abovementioned correlation analysis. Results: A positive correlation was found between the severity of agitation and 11C‐DPA713‐BPND in the Braak 1–3 area, including the amygdala, hippocampal and parahippocampal regions, and lingual and fusiform areas. An increase in the 11C‐DPA713‐BPND was observed in AD patients with agitation. We did not find any significant effects of possible confounding factors, such as age, duration of illness, education, gender, Mini‐Mental State Examination score, cerebrospinal fluid amyloid β 42/40 ratio, and apolipoprotein E4 positivity, on either the 11C‐DPA713‐BPND or agitation score. Conclusions: Neuroinflammation in the medial temporal region and its neighbouring area was shown to be associated with the development of agitation symptoms in AD patients. Our findings extend those of previous studies showing an association between some NPS and inflammation, suggesting that immunologically based interventions for agitation can serve as an alternative treatment for dementia. [ABSTRACT FROM AUTHOR]
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- 2023
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48. Possibility for Prevention of Type 2 Diabetes Mellitus and Dementia Using Three Kinds of Brown Rice Blends after High-Pressure Treatment
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Nakamura, Sumiko, primary, Ikeuchi, Takeshi, additional, Araki, Aki, additional, Kasuga, Kensaku, additional, Watanabe, Kenichi, additional, Hirayama, Masao, additional, Ito, Mitsutoshi, additional, and Ohtsubo, Ken’ichi, additional
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- 2022
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49. Development of a Novel Nutrition-Related Multivariate Biomarker for Mild Cognitive Impairment Based on the Plasma Free Amino Acid Profile
- Author
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Ikeuchi, Takeshi, primary, Yano, Yuki, additional, Sato, Wataru, additional, Morikawa, Fumiyoshi, additional, Toru, Shuta, additional, Nishimura, Chika, additional, Miyazawa, Nobuhiko, additional, Kuroha, Yasuko, additional, Koike, Ryoko, additional, Tanaka, Shin, additional, Utsumi, Kumiko, additional, Kasuga, Kensaku, additional, Tokutake, Takayoshi, additional, Ono, Kenjiro, additional, Yano, Satoshi, additional, Naruse, Satoshi, additional, Yajima, Ryuji, additional, Hamano, Tadanori, additional, Yokoyama, Yuri, additional, Kitamura, Akihiko, additional, Kaneko, Eiji, additional, Yamakado, Minoru, additional, and Nagao, Kenji, additional
- Published
- 2022
- Full Text
- View/download PDF
50. White Matter Lesions May Aid in Differentiating Idiopathic Normal Pressure Hydrocephalus and Alzheimer’s Disease
- Author
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Kuroda, Takeshi, primary, Honma, Motoyasu, additional, Mori, Yukiko, additional, Futamura, Akinori, additional, Sugimoto, Azusa, additional, Kasai, Hideyo, additional, Yano, Satoshi, additional, Hieda, Sotaro, additional, Kasuga, Kensaku, additional, Ikeuchi, Takeshi, additional, and Ono, Kenjiro, additional
- Published
- 2022
- Full Text
- View/download PDF
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