Search

Your search keyword '"Kasri, Nael Nadif"' showing total 182 results
Start Over Author "Kasri, Nael Nadif"
182 results on '"Kasri, Nael Nadif"'

1. Multiscale modeling uncovers 7q11.23 copy number variation-dependent changes in ribosomal biogenesis and neuronal maturation and excitability

Author

Mihailovich, Marija, Germain, Pierre-Luc, Shyti, Reinald, Pozzi, Davide, Noberini, Roberta, Liu, Yansheng, Aprile, Davide, Tenderini, Erika, Troglio, Flavia, Trattaro, Sebastiano, Fabris, Sonia, Ciptasari, Ummi, Rigoli, Marco Tullio, Caporale, Nicolo, D'Agostino, Giuseppe, Mirabella, Filippo, Vitriolo, Alessandro, Capocefalo, Daniele, Skaros, Adrianos, Franchini, Agnese Virginia, Ricciardi, Sara, Biunno, Ida, Neri, Antonino, Kasri, Nael Nadif, Bonaldi, Tiziana, Aebersold, Rudolf, Matteoli, Michela, and Testa, Giuseppe

Subjects
Genetic aspects, Research, Risk factors, Health aspects, Organelle biogenesis -- Genetic aspects -- Health aspects, Neurological research, Copy number variations -- Research, Nervous system diseases -- Risk factors -- Genetic aspects, Ribosomes -- Genetic aspects -- Health aspects, Gene expression -- Research, Developmental disabilities -- Risk factors -- Genetic aspects, Neurons -- Genetic aspects -- Health aspects, Child development deviations -- Risk factors -- Genetic aspects, Cell organelles -- Formation
Abstract

Introduction With over a thousand associated genes and an increasing number of polygenic risk variants, neurodevelopmental disorders (NDDs), in particular autism spectrum disorder (ASD) and intellectual disability (ID), continue to [...], Copy number variation (CNV) at 7q11.23 causes Williams-Beuren syndrome (WBS) and 7q microduplication syndrome (7Dup), neurodevelopmental disorders (NDDs) featuring intellectual disability accompanied by symmetrically opposite neurocognitive features. Although significant progress has been made in understanding the molecular mechanisms underlying 7q11.23- related pathophysiology, the propagation of CNV dosage across gene expression layers and their interplay remains elusive. Here we uncovered 7q11.23 dosage-dependent symmetrically opposite dynamics in neuronal differentiation and intrinsic excitability. By integrating transcriptomics, translatomics, and proteomics of patient-derived and isogenic induced neurons, we found that genes related to neuronal transmission follow 7q11.23 dosage and are transcriptionally controlled, while translational factors and ribosomal genes are posttranscriptionally buffered. Consistently, we found phosphorylated RPS6 (p-RPS6) downregulated in WBS and upregulated in 7Dup. Surprisingly, p-4EBP was changed in the opposite direction, reflecting dosage- specific changes in total 4EBP levels. This highlights different dosage-sensitive dyregulations of the mTOR pathway as well as distinct roles of p-RPS6 and p-4EBP during neurogenesis. Our work demonstrates the importance of multiscale disease modeling across molecular and functional layers, uncovers the pathophysiological relevance of ribosomal biogenesis in a paradigmatic pair of NDDs, and uncouples the roles of p-RPS6 and p-4EBP as mechanistically actionable relays in NDDs.

Published
2024
Full Text
View/download PDF

2. Comprehensive EHMT1 variants analysis broadens genotype-phenotype associations and molecular mechanisms in Kleefstra syndrome

Author

Rots, Dmitrijs, Bouman, Arianne, Yamada, Ayumi, Levy, Michael, Dingemans, Alexander J.M., de Vries, Bert B.A., Ruiterkamp-Versteeg, Martina, de Leeuw, Nicole, Ockeloen, Charlotte W., Pfundt, Rolph, de Boer, Elke, Kummeling, Joost, van Bon, Bregje, van Bokhoven, Hans, Kasri, Nael Nadif, Venselaar, Hanka, Alders, Marielle, Kerkhof, Jennifer, McConkey, Haley, Kuechler, Alma, Elffers, Bart, van Beeck Calkoen, Rixje, Hofman, Susanna, Smith, Audrey, Valenzuela, Maria Irene, Srivastava, Siddharth, Frazier, Zoe, Maystadt, Isabelle, Piscopo, Carmelo, Merla, Giuseppe, Balasubramanian, Meena, Santen, Gijs W.E., Metcalfe, Kay, Park, Soo-Mi, Pasquier, Laurent, Banka, Siddharth, Donnai, Dian, Weisberg, Daniel, Strobl-Wildemann, Gertrud, Wagemans, Annemieke, Vreeburg, Maaike, Baralle, Diana, Foulds, Nicola, Scurr, Ingrid, Brunetti-Pierri, Nicola, van Hagen, Johanna M., Bijlsma, Emilia K., Hakonen, Anna H., Courage, Carolina, Genevieve, David, Pinson, Lucile, Forzano, Francesca, Deshpande, Charu, Kluskens, Maria L., Welling, Lindsey, Plomp, Astrid S., Vanhoutte, Els K., Kalsner, Louisa, Hol, Janna A., Putoux, Audrey, Lazier, Johanna, Vasudevan, Pradeep, Ames, Elizabeth, O'Shea, Jessica, Lederer, Damien, Fleischer, Julie, O'Connor, Mary, Pauly, Melissa, Vasileiou, Georgia, Reis, André, Kiraly-Borri, Catherine, Bouman, Arjan, Barnett, Chris, Nezarati, Marjan, Borch, Lauren, Beunders, Gea, Özcan, Kübra, Miot, Stéphanie, Volker-Touw, Catharina M.L., van Gassen, Koen L.I., Cappuccio, Gerarda, Janssens, Katrien, Mor, Nofar, Shomer, Inna, Dominissini, Dan, Tedder, Matthew L., Muir, Alison M., Sadikovic, Bekim, Brunner, Han G., Vissers, Lisenka E.L.M., Shinkai, Yoichi, and Kleefstra, Tjitske

Published
2024
Full Text
View/download PDF

3. Basolateral amygdala activation enhances object recognition memory by inhibiting anterior insular cortex activity

Author

Chen, Yan-Fen, Song, Qi, Colucci, Paola, Maltese, Federica, Siller-Pérez, Cristina, Prins, Karina, McGaugh, James L, Hermans, Erno J, Campolongo, Patrizia, Kasri, Nael Nadif, and Roozendaal, Benno

Subjects
Biological Psychology, Pharmacology and Pharmaceutical Sciences, Biomedical and Clinical Sciences, Psychology, Mental Health, Behavioral and Social Science, Basic Behavioral and Social Science, Neurosciences, Mental health, Animals, Arousal, Basolateral Nuclear Complex, Cyclic AMP Response Element-Binding Protein, Emotions, GABA Agonists, Insular Cortex, Male, Neural Inhibition, Norepinephrine, Rats, Rats, Sprague-Dawley, Recognition, Psychology, Visual Perception, basolateral amygdala, norepinephrine, emotional arousal, insular cortex, salience network
Abstract

Noradrenergic activation of the basolateral amygdala (BLA) by emotional arousal enhances different forms of recognition memory via functional interactions with the insular cortex (IC). Human neuroimaging studies have revealed that the anterior IC (aIC), as part of the salience network, is dynamically regulated during arousing situations. Emotional stimulation first rapidly increases aIC activity but suppresses it in a delayed fashion. Here, we investigated in male Sprague-Dawley rats whether the BLA influence on recognition memory is associated with an increase or suppression of aIC activity during the postlearning consolidation period. We first employed anterograde and retrograde viral tracing and found that the BLA sends dense monosynaptic projections to the aIC. Memory-enhancing norepinephrine administration into the BLA following an object training experience suppressed aIC activity 1 h later, as determined by a reduced expression of the phosphorylated form of the transcription factor cAMP response element-binding (pCREB) protein and neuronal activity marker c-Fos. In contrast, the number of perisomatic γ-aminobutyric acid (GABA)ergic inhibitory synapses per pCREB-positive neuron was significantly increased, suggesting a dynamic up-regulation of GABAergic tone. In support of this possibility, pharmacological inhibition of aIC activity with a GABAergic agonist during consolidation enhanced object recognition memory. Norepinephrine administration into the BLA did not affect neuronal activity within the posterior IC, which receives sparse innervation from the BLA. The evidence that noradrenergic activation of the BLA enhances the consolidation of object recognition memory via a mechanism involving a suppression of aIC activity provides insight into the broader brain network dynamics underlying emotional regulation of memory.

Published
2022

7. Human Pluripotent Stem Cell-Derived Astrocyte Functionality Compares Favorably with Primary Rat Astrocytes

Author

Lendemeijer, Bas, Unkel, Maurits, Smeenk, Hilde, Mossink, Britt, Hijazi, Sara, Gordillo-Sampedro, Sara, Shpak, Guy, Slump, Denise E., van den Hout, Mirjam C.G.N., van IJcken, Wilfred F.J., Bindels, Eric M.J., Hoogendijk, Witte J.G., Kasri, Nael Nadif, de Vrij, Femke M.S., Kushner, Steven A., Lendemeijer, Bas, Unkel, Maurits, Smeenk, Hilde, Mossink, Britt, Hijazi, Sara, Gordillo-Sampedro, Sara, Shpak, Guy, Slump, Denise E., van den Hout, Mirjam C.G.N., van IJcken, Wilfred F.J., Bindels, Eric M.J., Hoogendijk, Witte J.G., Kasri, Nael Nadif, de Vrij, Femke M.S., and Kushner, Steven A.

Published
2024

8. Comprehensive EHMT1 variants analysis broadens genotype-phenotype associations and molecular mechanisms in Kleefstra syndrome

Author

Genetica, Genetica Klinische Genetica, Genetica Sectie Genoomdiagnostiek, Child Health, Rots, Dmitrijs, Bouman, Arianne, Yamada, Ayumi, Levy, Michael, Dingemans, Alexander J.M., de Vries, Bert B.A., Ruiterkamp-Versteeg, Martina, de Leeuw, Nicole, Ockeloen, Charlotte W., Pfundt, Rolph, de Boer, Elke, Kummeling, Joost, van Bon, Bregje, van Bokhoven, Hans, Kasri, Nael Nadif, Venselaar, Hanka, Alders, Marielle, Kerkhof, Jennifer, McConkey, Haley, Kuechler, Alma, Elffers, Bart, van Beeck Calkoen, Rixje, Hofman, Susanna, Smith, Audrey, Valenzuela, Maria Irene, Srivastava, Siddharth, Frazier, Zoe, Maystadt, Isabelle, Piscopo, Carmelo, Merla, Giuseppe, Balasubramanian, Meena, Santen, Gijs W.E., Metcalfe, Kay, Park, Soo Mi, Pasquier, Laurent, Banka, Siddharth, Donnai, Dian, Weisberg, Daniel, Strobl-Wildemann, Gertrud, Wagemans, Annemieke, Vreeburg, Maaike, Baralle, Diana, Foulds, Nicola, Scurr, Ingrid, Brunetti-Pierri, Nicola, van Hagen, Johanna M., Bijlsma, Emilia K., Hakonen, Anna H., Courage, Carolina, Genevieve, David, Pinson, Lucile, Forzano, Francesca, Deshpande, Charu, Kluskens, Maria L., Welling, Lindsey, Plomp, Astrid S., Vanhoutte, Els K., Kalsner, Louisa, Hol, Janna A., Putoux, Audrey, Lazier, Johanna, Vasudevan, Pradeep, Ames, Elizabeth, O'Shea, Jessica, Lederer, Damien, Fleischer, Julie, O'Connor, Mary, Pauly, Melissa, Vasileiou, Georgia, Reis, André, Kiraly-Borri, Catherine, Bouman, Arjan, Barnett, Chris, Nezarati, Marjan, Borch, Lauren, Beunders, Gea, Özcan, Kübra, Miot, Stéphanie, Volker-Touw, Catharina M.L., van Gassen, Koen L.I., Cappuccio, Gerarda, Janssens, Katrien, Mor, Nofar, Shomer, Inna, Dominissini, Dan, Tedder, Matthew L., Muir, Alison M., Sadikovic, Bekim, Brunner, Han G., Vissers, Lisenka E.L.M., Shinkai, Yoichi, Kleefstra, Tjitske, Genetica, Genetica Klinische Genetica, Genetica Sectie Genoomdiagnostiek, Child Health, Rots, Dmitrijs, Bouman, Arianne, Yamada, Ayumi, Levy, Michael, Dingemans, Alexander J.M., de Vries, Bert B.A., Ruiterkamp-Versteeg, Martina, de Leeuw, Nicole, Ockeloen, Charlotte W., Pfundt, Rolph, de Boer, Elke, Kummeling, Joost, van Bon, Bregje, van Bokhoven, Hans, Kasri, Nael Nadif, Venselaar, Hanka, Alders, Marielle, Kerkhof, Jennifer, McConkey, Haley, Kuechler, Alma, Elffers, Bart, van Beeck Calkoen, Rixje, Hofman, Susanna, Smith, Audrey, Valenzuela, Maria Irene, Srivastava, Siddharth, Frazier, Zoe, Maystadt, Isabelle, Piscopo, Carmelo, Merla, Giuseppe, Balasubramanian, Meena, Santen, Gijs W.E., Metcalfe, Kay, Park, Soo Mi, Pasquier, Laurent, Banka, Siddharth, Donnai, Dian, Weisberg, Daniel, Strobl-Wildemann, Gertrud, Wagemans, Annemieke, Vreeburg, Maaike, Baralle, Diana, Foulds, Nicola, Scurr, Ingrid, Brunetti-Pierri, Nicola, van Hagen, Johanna M., Bijlsma, Emilia K., Hakonen, Anna H., Courage, Carolina, Genevieve, David, Pinson, Lucile, Forzano, Francesca, Deshpande, Charu, Kluskens, Maria L., Welling, Lindsey, Plomp, Astrid S., Vanhoutte, Els K., Kalsner, Louisa, Hol, Janna A., Putoux, Audrey, Lazier, Johanna, Vasudevan, Pradeep, Ames, Elizabeth, O'Shea, Jessica, Lederer, Damien, Fleischer, Julie, O'Connor, Mary, Pauly, Melissa, Vasileiou, Georgia, Reis, André, Kiraly-Borri, Catherine, Bouman, Arjan, Barnett, Chris, Nezarati, Marjan, Borch, Lauren, Beunders, Gea, Özcan, Kübra, Miot, Stéphanie, Volker-Touw, Catharina M.L., van Gassen, Koen L.I., Cappuccio, Gerarda, Janssens, Katrien, Mor, Nofar, Shomer, Inna, Dominissini, Dan, Tedder, Matthew L., Muir, Alison M., Sadikovic, Bekim, Brunner, Han G., Vissers, Lisenka E.L.M., Shinkai, Yoichi, and Kleefstra, Tjitske

Published
2024

10. Navigating Human Astrocyte Differentiation: Direct and Rapid one-step Differentiation of Induced Pluripotent Stem Cells to Functional Astrocytes Supporting Neuronal Network development

Author

Schuurmans, Imke M. E., primary, Mordelt, Annika, additional, Linda, Katrin, additional, Puvogel, Sofia, additional, Duineveld, Denise, additional, Hommersom, Marina P, additional, Rahm, Lisa, additional, Dyke, Emma, additional, Scholten, Gijs-Jan, additional, Knorz, Caroline, additional, Oudakker, Astrid, additional, van Bokhoven, Hans, additional, de Witte, Lot D, additional, van Karnebeek, Clara D.M., additional, Garanto, Alejandro, additional, and Kasri, Nael Nadif, additional

Published
2024
Full Text
View/download PDF

14. FriendlyClearMap: an optimized toolkit for mouse brain mapping and analysis

Author

Negwer, M.J., Bosch, Bram, Bormann, M., Hesen, R., Lütje, L., Aarts, L., Rossing, C., Kasri, Nael Nadif, Schubert, D., Negwer, M.J., Bosch, Bram, Bormann, M., Hesen, R., Lütje, L., Aarts, L., Rossing, C., Kasri, Nael Nadif, and Schubert, D.

Abstract

Contains fulltext : 295430.pdf (Publisher’s version ) (Open Access)

Published
2023

15. ANK2 loss-of-function variants are associated with epilepsy, and lead to impaired axon initial segment plasticity and hyperactive network activity in hiPSC-derived neuronal networks

Author

Genetica Klinische Genetica, Brain, Teunissen, Maria W A, Lewerissa, Elly, van Hugte, Eline J H, Wang, Shan, Ockeloen, Charlotte W, Koolen, David A, Pfundt, Rolph, Marcelis, Carlo L M, Brilstra, Eva, Howe, Jennifer L, Scherer, Stephen W, Le Guillou, Xavier, Bilan, Frédéric, Primiano, Michelle, Roohi, Jasmin, Piton, Amelie, de Saint Martin, Anne, Baer, Sarah, Seiffert, Simone, Platzer, Konrad, Jamra, Rami Abou, Syrbe, Steffen, Doering, Jan Henje, Lakhani, Shenela, Nangia, Srishti, Gilissen, Christian, Vermeulen, R Jeroen, Rouhl, Rob P W, Brunner, Han G, Willemsen, Marjolein H, Kasri, Nael Nadif, Genetica Klinische Genetica, Brain, Teunissen, Maria W A, Lewerissa, Elly, van Hugte, Eline J H, Wang, Shan, Ockeloen, Charlotte W, Koolen, David A, Pfundt, Rolph, Marcelis, Carlo L M, Brilstra, Eva, Howe, Jennifer L, Scherer, Stephen W, Le Guillou, Xavier, Bilan, Frédéric, Primiano, Michelle, Roohi, Jasmin, Piton, Amelie, de Saint Martin, Anne, Baer, Sarah, Seiffert, Simone, Platzer, Konrad, Jamra, Rami Abou, Syrbe, Steffen, Doering, Jan Henje, Lakhani, Shenela, Nangia, Srishti, Gilissen, Christian, Vermeulen, R Jeroen, Rouhl, Rob P W, Brunner, Han G, Willemsen, Marjolein H, and Kasri, Nael Nadif

Published
2023

20. SCN1A-deficient excitatory neuronal networks display mutation-specific phenotypes.

Author

Hugte, Eline J H van, Lewerissa, Elly I, Wu, Ka Man, Scheefhals, Nicky, Parodi, Giulia, Voorst, Torben W van, Puvogel, Sofia, Kogo, Naoki, Keller, Jason M, Frega, Monica, Schubert, Dirk, Schelhaas, Helenius J, Verhoeven, Judith, Majoie, Marian, Bokhoven, Hans van, and Kasri, Nael Nadif

Subjects
NEURAL circuitry, EPILEPSY, PHENOTYPES, FEBRILE seizures, MISSENSE mutation, ANTICONVULSANTS
Abstract

Dravet syndrome is a severe epileptic encephalopathy, characterized by (febrile) seizures, behavioural problems and developmental delay. Eighty per cent of patients with Dravet syndrome have a mutation in SCN1A , encoding Nav1.1. Milder clinical phenotypes, such as GEFS+ (generalized epilepsy with febrile seizures plus), can also arise from SCN1A mutations. Predicting the clinical phenotypic outcome based on the type of mutation remains challenging, even when the same mutation is inherited within one family. This clinical and genetic heterogeneity adds to the difficulties of predicting disease progression and tailoring the prescription of anti-seizure medication. Understanding the neuropathology of different SCN1A mutations may help to predict the expected clinical phenotypes and inform the selection of best-fit treatments. Initially, the loss of Na+-current in inhibitory neurons was recognized specifically to result in disinhibition and consequently seizure generation. However, the extent to which excitatory neurons contribute to the pathophysiology is currently debated and might depend on the patient clinical phenotype or the specific SCN1A mutation. To examine the genotype-phenotype correlations of SCN1A mutations in relation to excitatory neurons, we investigated a panel of patient-derived excitatory neuronal networks differentiated on multi-electrode arrays. We included patients with different clinical phenotypes, harbouring various SCN1A mutations, along with a family in which the same mutation led to febrile seizures, GEFS+ or Dravet syndrome. We hitherto describe a previously unidentified functional excitatory neuronal network phenotype in the context of epilepsy, which corresponds to seizurogenic network prediction patterns elicited by proconvulsive compounds. We found that excitatory neuronal networks were affected differently, depending on the type of S CN1A mutation, but did not segregate according to clinical severity. Specifically, loss-of-function mutations could be distinguished from missense mutations, and mutations in the pore domain could be distinguished from mutations in the voltage sensing domain. Furthermore, all patients showed aggravated neuronal network responses at febrile temperatures compared with controls. Finally, retrospective drug screening revealed that anti-seizure medication affected GEFS+ patient- but not Dravet patient-derived neuronal networks in a patient-specific and clinically relevant manner. In conclusion, our results indicate a mutation-specific excitatory neuronal network phenotype, which recapitulates the foremost clinically relevant features, providing future opportunities for precision therapies. [ABSTRACT FROM AUTHOR]

Published
2023
Full Text
View/download PDF

21. 7q11.23 CNV alters protein synthesis and REST-mediated neuronal intrinsic excitability

Author

Mihailovich, Marija, primary, Germain, Pierre-Luc, additional, Shyti, Reinald, additional, Pozzi, Davide, additional, Noberini, Roberta, additional, Liu, Yansheng, additional, Aprile, Davide, additional, Tenderini, Erika, additional, Troglio, Flavia, additional, Trattaro, Sebastiano, additional, Fabris, Sonia, additional, Ciptasari, Ummi, additional, Rigoli, Marco Tullio, additional, Caporale, Nicolò, additional, D’Agostino, Giuseppe, additional, Vitriolo, Alessandro, additional, Capocefalo, Daniele, additional, Skaros, Adrianos, additional, Franchini, Agnese, additional, Ricciardi, Sara, additional, Biunno, Ida, additional, Neri, Antonino, additional, Kasri, Nael Nadif, additional, Bonaldi, Tiziana, additional, Aebersold, Rudolf, additional, Matteoli, Michela, additional, and Testa, Giuseppe, additional

Published
2022
Full Text
View/download PDF

22. Disruption of an EHMT1-Associated Chromatin-Modification Module Causes Intellectual Disability

Author

Kleefstra, Tjitske, Kramer, Jamie M., Neveling, Kornelia, Willemsen, Marjolein H., Koemans, Tom S., Vissers, Lisenka E.L.M., Wissink-Lindhout, Willemijn, Fenckova, Michaela, van den Akker, Willem M.R., Kasri, Nael Nadif, Nillesen, Willy M., Prescott, Trine, Clark, Robin D., Devriendt, Koenraad, van Reeuwijk, Jeroen, de Brouwer, Arjan P.M., Gilissen, Christian, Zhou, Huiqing, Brunner, Han G., Veltman, Joris A., Schenck, Annette, and van Bokhoven, Hans

Published
2012
Full Text
View/download PDF

23. Regulation of mitophagy by the NSL complex underlies genetic risk for Parkinson’s disease at 16q11.2 and MAPT H1 loci

Author

Soutar, Marc P M, primary, Melandri, Daniela, additional, O’Callaghan, Benjamin, additional, Annuario, Emily, additional, Monaghan, Amy E, additional, Welsh, Natalie J, additional, D’Sa, Karishma, additional, Guelfi, Sebastian, additional, Zhang, David, additional, Pittman, Alan, additional, Trabzuni, Daniah, additional, Verboven, Anouk H A, additional, Pan, Kylie S, additional, Kia, Demis A, additional, Bictash, Magda, additional, Gandhi, Sonia, additional, Houlden, Henry, additional, Cookson, Mark R, additional, Kasri, Nael Nadif, additional, Wood, Nicholas W, additional, Singleton, Andrew B, additional, Hardy, John, additional, Whiting, Paul J, additional, Blauwendraat, Cornelis, additional, Whitworth, Alexander J, additional, Manzoni, Claudia, additional, Ryten, Mina, additional, Lewis, Patrick A, additional, and Plun-Favreau, Hélène, additional

Published
2022
Full Text
View/download PDF

28. The continued need for animals to advance brain research

Author

Homberg, Judith R., primary, Adan, Roger A.H., additional, Alenina, Natalia, additional, Asiminas, Antonis, additional, Bader, Michael, additional, Beckers, Tom, additional, Begg, Denovan P., additional, Blokland, Arjan, additional, Burger, Marilise E., additional, van Dijk, Gertjan, additional, Eisel, Ulrich L.M., additional, Elgersma, Ype, additional, Englitz, Bernhard, additional, Fernandez-Ruiz, Antonio, additional, Fitzsimons, Carlos P., additional, van Dam, Anne-Marie, additional, Gass, Peter, additional, Grandjean, Joanes, additional, Havekes, Robbert, additional, Henckens, Marloes J.A.G., additional, Herden, Christiane, additional, Hut, Roelof A., additional, Jarrett, Wendy, additional, Jeffrey, Kate, additional, Jezova, Daniela, additional, Kalsbeek, Andries, additional, Kamermans, Maarten, additional, Kas, Martien J., additional, Kasri, Nael Nadif, additional, Kiliaan, Amanda J., additional, Kolk, Sharon M., additional, Korosi, Aniko, additional, Korte, S. Mechiel, additional, Kozicz, Tamas, additional, Kushner, Steven A., additional, Leech, Kirk, additional, Lesch, Klaus-Peter, additional, Lesscher, Heidi, additional, Lucassen, Paul J., additional, Luthi, Anita, additional, Ma, Liya, additional, Mallien, Anne S., additional, Meerlo, Peter, additional, Mejias, Jorge F., additional, Meye, Frank J., additional, Mitchell, Anna S., additional, Mul, Joram D., additional, Olcese, Umberto, additional, González, Azahara Oliva, additional, Olivier, Jocelien D.A., additional, Pasqualetti, Massimo, additional, Pennartz, Cyriel M.A., additional, Popik, Piotr, additional, Prickaerts, Jos, additional, de la Prida, Liset M., additional, Ribeiro, Sidarta, additional, Roozendaal, Benno, additional, Rossato, Janine I., additional, Salari, Ali-Akbar, additional, Schoemaker, Regien G., additional, Smit, August B., additional, Vanderschuren, Louk J.M.J., additional, Takeuchi, Tomonori, additional, van der Veen, Rixt, additional, Smidt, Marten P., additional, Vyazovskiy, Vladyslav V., additional, Wiesmann, Maximilian, additional, Wierenga, Corette J., additional, Williams, Bella, additional, Willuhn, Ingo, additional, Wöhr, Markus, additional, Wolvekamp, Monique, additional, van der Zee, Eddy A., additional, and Genzel, Lisa, additional

Published
2021
Full Text
View/download PDF

29. The continued need for animals to advance brain research

Author

Homberg, Judith R, Adan, Roger A H, Alenina, Natalia, Asiminas, Antonis, Bader, Michael, Beckers, Tom, Begg, Denovan P, Blokland, Arjan, Burger, Marilise E, van Dijk, Gertjan, Eisel, Ulrich L M, Elgersma, Ype, Englitz, Bernhard, Fernandez-Ruiz, Antonio, Fitzsimons, Carlos P, van Dam, Anne-Marie, Gass, Peter, Grandjean, Joanes, Havekes, Robbert, Henckens, Marloes J A G, Herden, Christiane, Hut, Roelof A, Jarrett, Wendy, Jeffrey, Kate, Jezova, Daniela, Kalsbeek, Andries, Kamermans, Maarten, Kas, Martien J, Kasri, Nael Nadif, Kiliaan, Amanda J, Kolk, Sharon M, Korosi, Aniko, Korte, S Mechiel, Kozicz, Tamas, Kushner, Steven A, Leech, Kirk, Lesch, Klaus-Peter, Lesscher, Heidi, Lucassen, Paul J, Luthi, Anita, Ma, Liya, Mallien, Anne S, Meerlo, Peter, Mejias, Jorge F, Meye, Frank J, Mitchell, Anna S, Mul, Joram D, Olcese, Umberto, González, Azahara Oliva, Olivier, Jocelien D A, Pasqualetti, Massimo, Pennartz, Cyriel M A, Popik, Piotr, Prickaerts, Jos, de la Prida, Liset M, Ribeiro, Sidarta, Roozendaal, Benno, Rossato, Janine I, Salari, Ali-Akbar, Schoemaker, Regien G, Smit, August B, Vanderschuren, Louk J M J, Takeuchi, Tomonori, van der Veen, Rixt, Smidt, Marten P, Vyazovskiy, Vladyslav V, Wiesmann, Maximilian, Wierenga, Corette J, Williams, Bella, Willuhn, Ingo, Wöhr, Markus, Wolvekamp, Monique, van der Zee, Eddy A, Genzel, Lisa, Homberg, Judith R, Adan, Roger A H, Alenina, Natalia, Asiminas, Antonis, Bader, Michael, Beckers, Tom, Begg, Denovan P, Blokland, Arjan, Burger, Marilise E, van Dijk, Gertjan, Eisel, Ulrich L M, Elgersma, Ype, Englitz, Bernhard, Fernandez-Ruiz, Antonio, Fitzsimons, Carlos P, van Dam, Anne-Marie, Gass, Peter, Grandjean, Joanes, Havekes, Robbert, Henckens, Marloes J A G, Herden, Christiane, Hut, Roelof A, Jarrett, Wendy, Jeffrey, Kate, Jezova, Daniela, Kalsbeek, Andries, Kamermans, Maarten, Kas, Martien J, Kasri, Nael Nadif, Kiliaan, Amanda J, Kolk, Sharon M, Korosi, Aniko, Korte, S Mechiel, Kozicz, Tamas, Kushner, Steven A, Leech, Kirk, Lesch, Klaus-Peter, Lesscher, Heidi, Lucassen, Paul J, Luthi, Anita, Ma, Liya, Mallien, Anne S, Meerlo, Peter, Mejias, Jorge F, Meye, Frank J, Mitchell, Anna S, Mul, Joram D, Olcese, Umberto, González, Azahara Oliva, Olivier, Jocelien D A, Pasqualetti, Massimo, Pennartz, Cyriel M A, Popik, Piotr, Prickaerts, Jos, de la Prida, Liset M, Ribeiro, Sidarta, Roozendaal, Benno, Rossato, Janine I, Salari, Ali-Akbar, Schoemaker, Regien G, Smit, August B, Vanderschuren, Louk J M J, Takeuchi, Tomonori, van der Veen, Rixt, Smidt, Marten P, Vyazovskiy, Vladyslav V, Wiesmann, Maximilian, Wierenga, Corette J, Williams, Bella, Willuhn, Ingo, Wöhr, Markus, Wolvekamp, Monique, van der Zee, Eddy A, and Genzel, Lisa

Abstract

Policymakers aim to move toward animal-free alternatives for scientific research and have introduced very strict regulations for animal research. We argue that, for neuroscience research, until viable and translational alternatives become available and the value of these alternatives has been proven, the use of animals should not be compromised.

Published
2021

30. The continued need for animals to advance brain research

Author

Afd Pharmacology, AISS Behaviour Neuroscience, dASS BW-1, Sub Cell Biology, Pharmacology, Celbiologie, Homberg, Judith R, Adan, Roger A H, Alenina, Natalia, Asiminas, Antonis, Bader, Michael, Beckers, Tom, Begg, Denovan P, Blokland, Arjan, Burger, Marilise E, van Dijk, Gertjan, Eisel, Ulrich L M, Elgersma, Ype, Englitz, Bernhard, Fernandez-Ruiz, Antonio, Fitzsimons, Carlos P, van Dam, Anne-Marie, Gass, Peter, Grandjean, Joanes, Havekes, Robbert, Henckens, Marloes J A G, Herden, Christiane, Hut, Roelof A, Jarrett, Wendy, Jeffrey, Kate, Jezova, Daniela, Kalsbeek, Andries, Kamermans, Maarten, Kas, Martien J, Kasri, Nael Nadif, Kiliaan, Amanda J, Kolk, Sharon M, Korosi, Aniko, Korte, S Mechiel, Kozicz, Tamas, Kushner, Steven A, Leech, Kirk, Lesch, Klaus-Peter, Lesscher, Heidi, Lucassen, Paul J, Luthi, Anita, Ma, Liya, Mallien, Anne S, Meerlo, Peter, Mejias, Jorge F, Meye, Frank J, Mitchell, Anna S, Mul, Joram D, Olcese, Umberto, González, Azahara Oliva, Olivier, Jocelien D A, Pasqualetti, Massimo, Pennartz, Cyriel M A, Popik, Piotr, Prickaerts, Jos, de la Prida, Liset M, Ribeiro, Sidarta, Roozendaal, Benno, Rossato, Janine I, Salari, Ali-Akbar, Schoemaker, Regien G, Smit, August B, Vanderschuren, Louk J M J, Takeuchi, Tomonori, van der Veen, Rixt, Smidt, Marten P, Vyazovskiy, Vladyslav V, Wiesmann, Maximilian, Wierenga, Corette J, Williams, Bella, Willuhn, Ingo, Wöhr, Markus, Wolvekamp, Monique, van der Zee, Eddy A, Genzel, Lisa, Afd Pharmacology, AISS Behaviour Neuroscience, dASS BW-1, Sub Cell Biology, Pharmacology, Celbiologie, Homberg, Judith R, Adan, Roger A H, Alenina, Natalia, Asiminas, Antonis, Bader, Michael, Beckers, Tom, Begg, Denovan P, Blokland, Arjan, Burger, Marilise E, van Dijk, Gertjan, Eisel, Ulrich L M, Elgersma, Ype, Englitz, Bernhard, Fernandez-Ruiz, Antonio, Fitzsimons, Carlos P, van Dam, Anne-Marie, Gass, Peter, Grandjean, Joanes, Havekes, Robbert, Henckens, Marloes J A G, Herden, Christiane, Hut, Roelof A, Jarrett, Wendy, Jeffrey, Kate, Jezova, Daniela, Kalsbeek, Andries, Kamermans, Maarten, Kas, Martien J, Kasri, Nael Nadif, Kiliaan, Amanda J, Kolk, Sharon M, Korosi, Aniko, Korte, S Mechiel, Kozicz, Tamas, Kushner, Steven A, Leech, Kirk, Lesch, Klaus-Peter, Lesscher, Heidi, Lucassen, Paul J, Luthi, Anita, Ma, Liya, Mallien, Anne S, Meerlo, Peter, Mejias, Jorge F, Meye, Frank J, Mitchell, Anna S, Mul, Joram D, Olcese, Umberto, González, Azahara Oliva, Olivier, Jocelien D A, Pasqualetti, Massimo, Pennartz, Cyriel M A, Popik, Piotr, Prickaerts, Jos, de la Prida, Liset M, Ribeiro, Sidarta, Roozendaal, Benno, Rossato, Janine I, Salari, Ali-Akbar, Schoemaker, Regien G, Smit, August B, Vanderschuren, Louk J M J, Takeuchi, Tomonori, van der Veen, Rixt, Smidt, Marten P, Vyazovskiy, Vladyslav V, Wiesmann, Maximilian, Wierenga, Corette J, Williams, Bella, Willuhn, Ingo, Wöhr, Markus, Wolvekamp, Monique, van der Zee, Eddy A, and Genzel, Lisa

Published
2021

31. The continued need for animals to advance brain research

Author

Homberg, Judith R., Adan, Roger A. H., Alenina, Natalia, Asiminas, Antonis, Bader, Michael, Beckers, Tom, Begg, Denovan P., Blokland, Arjan, Burger, Marilise E., van Dijk, Gertjan, Eisel, Ulrich L. M., Elgersma, Ype, Englitz, Bernhard, Fernandez-Ruiz, Antonio, Fitzsimons, Carlos P., van Dam, Anne-Marie, Gass, Peter, Grandjean, Joanes, Havekes, Robbert, Henckens, Marloes J. A. G., Herden, Christiane, Hut, Roelof A., Jarrett, Wendy, Jeffrey, Kate, Jezova, Daniela, Kalsbeek, Andries, Kamermans, Maarten, Kas, Martien J., Kasri, Nael Nadif, Kiliaan, Amanda J., Kolk, Sharon M., Korosi, Aniko, Korte, S. Mechiel, Kozicz, Tamas, Kushner, Steven A., Leech, Kirk, Leech, Klaus-Peter, Lesscher, Heidi, Lucassen, Paul J., Luthi, Anita, Ma, Liya, Mallien, Anne S., Meerlo, Peter, Mejias, Jorge F., Meye, Frank J., Mitchell, Anna S., Mul, Joram D., Olcese, Umberto, Gonzalez, Azahara Oliva, Oliver, Jocelien D. A., Pasqualetti, Massimo, Pennartz, CyrielM. A., Popik, Piotr, Prickaerts, Jos, de la Prida, Liset M., Ribeiro, Sidarta, Roozendaal, Benn, Rossato, Janine I., Salari, Ali-Akbar, Schoemaker, Regien G., Smit, August B., Takeuchi, Tomonori, van der Veen, Rixt, Smidt, Marten P., V. Vyazovskiy, Vladyslav, Wiesmann, Maximilian, Wierenga, Corette J., Williams, Bella, Willuhn, Ingo, Woehr, Markus, Wolvekamp, Monique, van der Zee, Eddy A., Genzel, Lisa, Vanderschuren, Louk J. M. J., Homberg, Judith R., Adan, Roger A. H., Alenina, Natalia, Asiminas, Antonis, Bader, Michael, Beckers, Tom, Begg, Denovan P., Blokland, Arjan, Burger, Marilise E., van Dijk, Gertjan, Eisel, Ulrich L. M., Elgersma, Ype, Englitz, Bernhard, Fernandez-Ruiz, Antonio, Fitzsimons, Carlos P., van Dam, Anne-Marie, Gass, Peter, Grandjean, Joanes, Havekes, Robbert, Henckens, Marloes J. A. G., Herden, Christiane, Hut, Roelof A., Jarrett, Wendy, Jeffrey, Kate, Jezova, Daniela, Kalsbeek, Andries, Kamermans, Maarten, Kas, Martien J., Kasri, Nael Nadif, Kiliaan, Amanda J., Kolk, Sharon M., Korosi, Aniko, Korte, S. Mechiel, Kozicz, Tamas, Kushner, Steven A., Leech, Kirk, Leech, Klaus-Peter, Lesscher, Heidi, Lucassen, Paul J., Luthi, Anita, Ma, Liya, Mallien, Anne S., Meerlo, Peter, Mejias, Jorge F., Meye, Frank J., Mitchell, Anna S., Mul, Joram D., Olcese, Umberto, Gonzalez, Azahara Oliva, Oliver, Jocelien D. A., Pasqualetti, Massimo, Pennartz, CyrielM. A., Popik, Piotr, Prickaerts, Jos, de la Prida, Liset M., Ribeiro, Sidarta, Roozendaal, Benn, Rossato, Janine I., Salari, Ali-Akbar, Schoemaker, Regien G., Smit, August B., Takeuchi, Tomonori, van der Veen, Rixt, Smidt, Marten P., V. Vyazovskiy, Vladyslav, Wiesmann, Maximilian, Wierenga, Corette J., Williams, Bella, Willuhn, Ingo, Woehr, Markus, Wolvekamp, Monique, van der Zee, Eddy A., Genzel, Lisa, and Vanderschuren, Louk J. M. J.

Abstract

C Policymakers aim to move toward animal-free alternatives for scientific research and have introduced very strict regulations for animal research. We argue that, for neuroscience research, until viable and translational alternatives become available and the value of these alternatives has been proven, the use of animals should not be compromised.

Published
2021

32. The continued need for animals to advance brain research

Author

TN groep Adan, Brain, TN groep Meye, Homberg, Judith R, Adan, Roger A H, Alenina, Natalia, Asiminas, Antonis, Bader, Michael, Beckers, Tom, Begg, Denovan P, Blokland, Arjan, Burger, Marilise E, van Dijk, Gertjan, Eisel, Ulrich L M, Elgersma, Ype, Englitz, Bernhard, Fernandez-Ruiz, Antonio, Fitzsimons, Carlos P, van Dam, Anne-Marie, Gass, Peter, Grandjean, Joanes, Havekes, Robbert, Henckens, Marloes J A G, Herden, Christiane, Hut, Roelof A, Jarrett, Wendy, Jeffrey, Kate, Jezova, Daniela, Kalsbeek, Andries, Kamermans, Maarten, Kas, Martien J, Kasri, Nael Nadif, Kiliaan, Amanda J, Kolk, Sharon M, Korosi, Aniko, Korte, S Mechiel, Kozicz, Tamas, Kushner, Steven A, Leech, Kirk, Lesch, Klaus-Peter, Lesscher, Heidi, Lucassen, Paul J, Luthi, Anita, Ma, Liya, Mallien, Anne S, Meerlo, Peter, Mejias, Jorge F, Meye, Frank J, Mitchell, Anna S, Mul, Joram D, Olcese, Umberto, González, Azahara Oliva, Olivier, Jocelien D A, Pasqualetti, Massimo, Pennartz, Cyriel M A, Popik, Piotr, Prickaerts, Jos, de la Prida, Liset M, Ribeiro, Sidarta, Roozendaal, Benno, Rossato, Janine I, Salari, Ali-Akbar, Schoemaker, Regien G, Smit, August B, Vanderschuren, Louk J M J, Takeuchi, Tomonori, van der Veen, Rixt, Smidt, Marten P, Vyazovskiy, Vladyslav V, Wiesmann, Maximilian, Wierenga, Corette J, Williams, Bella, Willuhn, Ingo, Wöhr, Markus, Wolvekamp, Monique, van der Zee, Eddy A, Genzel, Lisa, TN groep Adan, Brain, TN groep Meye, Homberg, Judith R, Adan, Roger A H, Alenina, Natalia, Asiminas, Antonis, Bader, Michael, Beckers, Tom, Begg, Denovan P, Blokland, Arjan, Burger, Marilise E, van Dijk, Gertjan, Eisel, Ulrich L M, Elgersma, Ype, Englitz, Bernhard, Fernandez-Ruiz, Antonio, Fitzsimons, Carlos P, van Dam, Anne-Marie, Gass, Peter, Grandjean, Joanes, Havekes, Robbert, Henckens, Marloes J A G, Herden, Christiane, Hut, Roelof A, Jarrett, Wendy, Jeffrey, Kate, Jezova, Daniela, Kalsbeek, Andries, Kamermans, Maarten, Kas, Martien J, Kasri, Nael Nadif, Kiliaan, Amanda J, Kolk, Sharon M, Korosi, Aniko, Korte, S Mechiel, Kozicz, Tamas, Kushner, Steven A, Leech, Kirk, Lesch, Klaus-Peter, Lesscher, Heidi, Lucassen, Paul J, Luthi, Anita, Ma, Liya, Mallien, Anne S, Meerlo, Peter, Mejias, Jorge F, Meye, Frank J, Mitchell, Anna S, Mul, Joram D, Olcese, Umberto, González, Azahara Oliva, Olivier, Jocelien D A, Pasqualetti, Massimo, Pennartz, Cyriel M A, Popik, Piotr, Prickaerts, Jos, de la Prida, Liset M, Ribeiro, Sidarta, Roozendaal, Benno, Rossato, Janine I, Salari, Ali-Akbar, Schoemaker, Regien G, Smit, August B, Vanderschuren, Louk J M J, Takeuchi, Tomonori, van der Veen, Rixt, Smidt, Marten P, Vyazovskiy, Vladyslav V, Wiesmann, Maximilian, Wierenga, Corette J, Williams, Bella, Willuhn, Ingo, Wöhr, Markus, Wolvekamp, Monique, van der Zee, Eddy A, and Genzel, Lisa

Published
2021

33. Loss-of-function variants in the schizophrenia risk gene SETD1A alter neuronal network activity in human neurons through cAMP/PKA pathway

Author

Wang, Shan, primary, van Rhijn, Jon-Ruben, additional, Akkouh, Ibrahim, additional, Kogo, Naoki, additional, Maas, Nadine, additional, Bleeck, Anna, additional, Ortiz, Irene Santisteban, additional, Lewerissa, Elly, additional, Wu, Ka Man, additional, Schoenmaker, Chantal, additional, Djurovic, Srdjan, additional, van Bokhoven, Hans, additional, Kleefstra, Tjitske, additional, Kasri, Nael Nadif, additional, and Schubert, Dirk, additional

Published
2021
Full Text
View/download PDF

39. Ngn2 induces diverse neuronal lineages from human pluripotency

Author

Lin, Hsiu-Chuan, primary, He, Zhisong, additional, Ebert, Sebastian, additional, Schörnig, Maria, additional, Santel, Malgorzata, additional, Weigert, Anne, additional, Hevers, Wulf, additional, Kasri, Nael Nadif, additional, Taverna, Elena, additional, Camp, J. Gray, additional, and Treutlein, Barbara, additional

Published
2020
Full Text
View/download PDF

40. Brunner syndrome associated MAOA dysfunction in human dopaminergic neurons results in NMDAR hyperfunction and increased network activity

Author

Shi, Yan, primary, van Rhijn, Jon-Ruben, additional, Bormann, Maren, additional, Mossink, Britt, additional, Frega, Monica, additional, Recaioglu, Hatice, additional, Hakobjan, Marina, additional, Gunnewiek, Teun Klein, additional, Schoenmaker, Chantal, additional, Palmer, Elizabeth, additional, Faivre, Laurence, additional, Kittel-Schneider, Sarah, additional, Schubert, Dirk, additional, Brunner, Han, additional, Franke, Barbara, additional, and Kasri, Nael Nadif, additional

Published
2020
Full Text
View/download PDF

41. KANSL1 Deficiency Causes Neuronal Dysfunction by Oxidative Stress-Induced Autophagy

Author

Linda, Katrin, primary, Lewerissa, EIly I., additional, Verboven, Anouk H. A., additional, Gabriele, Michele, additional, Frega, Monica, additional, Gunnewiek, Teun M. Klein, additional, Devilee, Lynn, additional, Ulferts, Edda, additional, Oudakker, Astrid, additional, Schoenmaker, Chantal, additional, van Bokhoven, Hans, additional, Schubert, Dirk, additional, Testa, Giuseppe, additional, Koolen, David A., additional, de Vries, Bert B.A., additional, and Kasri, Nael Nadif, additional

Published
2020
Full Text
View/download PDF

43. Cadherin-13 is a critical regulator of GABAergic modulation in human stem cell derived neuronal networks

Author

Mossink, Britt, primary, van Rhijn, Jon-Ruben, additional, Wang, Shan, additional, van Hugte, Eline J. H., additional, Linda, Katrin, additional, Bak, Jitske, additional, Verboven, Anouk H. A., additional, Selten, Martijn, additional, Anania, Alessia, additional, Jansen, Sophie, additional, Keller, Jason M., additional, Gunnewiek, Teun Klein, additional, Schoenmaker, Chantal, additional, Oudakker, Astrid, additional, Frega, Monica, additional, van Bokhoven, Hans, additional, Schubert, Dirk, additional, and Kasri, Nael Nadif, additional

Published
2020
Full Text
View/download PDF

44. Basolateral amygdala activation enhances object recognition memory by inhibiting anterior insular cortex activity.

Author

Yan-Fen Chen, Qi Song, Colucci, Paola, Maltese, Federica, Siller-Pérez, Cristina, Prins, Karina, McGaugh, James L., Hermans, Erno J., Campolongo, Patrizia, Kasri, Nael Nadif, and Roozendaal, Benno

Subjects
INSULAR cortex, OBJECT recognition (Computer vision), SALIENCE network, LARGE-scale brain networks, SCHOOL dropout prevention
Abstract

Noradrenergic activation of the basolateral amygdala (BLA) by emotional arousal enhances different forms of recognition memory via functional interactions with the insular cortex (IC). Human neuroimaging studies have revealed that the anterior IC (aIC), as part of the salience network, is dynamically regulated during arousing situations. Emotional stimulation first rapidly increases aIC activity but suppresses it in a delayed fashion. Here, we investigated in male Sprague-Dawley rats whether the BLA influence on recognition memory is associated with an increase or suppression of aIC activity during the postlearning consolidation period. We first employed anterograde and retrograde viral tracing and found that the BLA sends dense monosynaptic projections to the aIC. Memory-enhancing norepinephrine administration into the BLA following an object training experience suppressed aIC activity 1 h later, as determined by a reduced expression of the phosphorylated form of the transcription factor cAMP response element-binding (pCREB) protein and neuronal activity marker c-Fos. In contrast, the number of perisomatic γ-aminobutyric acid (GABA)ergic inhibitory synapses per pCREB-positive neuron was significantly increased, suggesting a dynamic up-regulation of GABAergic tone. In support of this possibility, pharmacological inhibition of aIC activity with a GABAergic agonist during consolidation enhanced object recognition memory. Norepinephrine administration into the BLA did not affect neuronal activity within the posterior IC, which receives sparse innervation from the BLA. The evidence that nor-adrenergic activation of the BLA enhances the consolidation of object recognition memory via a mechanism involving a suppression of aIC activity provides insight into the broader brain network dynamics underlying emotional regulation of memory. [ABSTRACT FROM AUTHOR]

Published
2022
Full Text
View/download PDF

48. Neuronal network dysfunction in a human model for Kleefstra syndrome mediated by enhanced NMDAR signaling

Author

Frega, Monica, primary, Linda, Katrin, additional, Keller, Jason M., additional, Gümüş-Akay, Güvem, additional, Mossink, Britt, additional, van Rhijn, Jon-Ruben, additional, Negwer, Moritz, additional, Gunnewiek, Teun Klein, additional, Foreman, Katharina, additional, Kompier, Nine, additional, Schoenmaker, Chantal, additional, van den Akker, Willem, additional, Oudakker, Astrid, additional, Zhou, Huiqing, additional, Kleefstra, Tjitske, additional, Schubert, Dirk, additional, van Bokhoven, Hans, additional, and Kasri, Nael Nadif, additional

Published
2019
Full Text
View/download PDF

49. F12AGGRESSION IN A DISH: A HUMAN MODEL FOR BRUNNER SYNDROME REVEALS INCREASED NEURONAL NETWORK ACTIVITY OF DOPAMINERGIC NEURONS

Author

Shi, Yan, primary, van Rhijn, Jon-Ruben, additional, Bormann, Maren, additional, Mossink, Britt, additional, Frega, Monica, additional, Hakobjan, Marina, additional, Kittel-Schneider, Sarah, additional, Keller, Jason, additional, Schubert, Dirk, additional, Brunner, Han, additional, Franke, Barbara, additional, and Kasri, Nael Nadif, additional

Published
2019
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results