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Introduction: Interpersonal relations significantly impact our well-being and mental health. They are also crucial among students, especially when they start living independently in a new social environment. The study aimed to determine the impact of relations on the occurrence of depression, anxiety, and drowsiness among medical students in Poland. Material and methods: An online questionnaire was created, consisting of four parts: the authors’ questionnaire on interpersonal relations, the Beck Depression Inventory (BDI), the Generalized Anxiety Disorder 7-item Scale (GAD-7), and the Epworth Sleepiness Scale (ESS). The results were analyzed using STATISTICA software. Results: 2339 completed questionnaires were obtained. 69.75% of the subjects had good/rather good relations with their co-tenants, and 5.04% – had bad/definitely bad. 85% of the participants had good relations with their parents. 65.63% of the respondents were satisfied with their social relationships; in addition, 71.91% of respondents were satisfied with their relationships with their friends. Poor relations with family and co-tenants, and poor social and friend relationships were linked to higher levels of depression, anxiety, and sleepiness. This phenomenon was particularly evident among introverts. Conclusions: Identifying the risk factors could significantly improve the prevention, diagnosis, and treatment of mental disorders in this group. Supporting students and paying greater attention to social competencies equally with medical knowledge acquired by them would be highly recommended.

Lipid disorders are the most common (even 70%) and worst monitored cardiovascular risk factor (only 1/4 of patients in Poland and in CEE countries are on the low-density lipoprotein cholesterol (LDL-C) goal). To improve this, clear and simple diagnostic criteria should be introduced for all components of the lipid profile. These are the updated guidelines of the two main scientific societies in Poland in the area – the Polish Society of Laboratory Diagnostics (PSLD) and the Polish Lipid Association (PoLA), which, in comparison to those from 2020, introduce few important changes in recommendations (two main lipid targets, new recommendations on LDL-C measurements, calculations new goals for triglycerides, new recommendations on remnants and small dense LDL) that should help the practitioners to be early with the diagnosis of lipid disorders and in the effective monitoring (after therapy initiation), and in the consequence to avoid the first and recurrent cardiovascular events.

This study presents a conceptual design of an Internet of Things (IoT) communication system for monitoring power generation systems in Colombian Non-Interconnected Zones (NIZs), which lack IoT connectivity due to complex geographical factors. The proposed system aims to ensure the proper operation and energy efficiency of off-grid systems while tracking the variables that influence their performance.The methods used in this study include identifying the needs of such a system, identifying requirements, obtaining technical specifications, and developing a conceptual design. The study also analyses and compares various technologies, including Wi-Fi, Bluetooth, LoRa and ZigBee, to determine which ones are best suited for IoT system design.The conceptual design of the proposed IoT monitoring system considers the geographical, communication and coverage characteristics of the NIZs and the technical characteristics of the energy projects to provide a complete functional system that can connect approximately 2 million people located in these isolated and vulnerable zones. Finally, the defined system can serve as a precedent for building prototypes in various NIZs, and research on IoT technologies suitable for NIZs can help us seek the technologies that are most suitable for these areas. Depending on the application and conditions of the energy project, the most appropriate technology can be determined on a case-by-case basis.

BackgroundIt has been reported that central adrenal insufficiency (CAI) in pediatric patients (pts) with Prader–Willi syndrome (PWS) may be a potential cause of their sudden death. In addition, the risk of CAI may increase during treatment with recombinant human growth hormone (rhGH).ObjectiveTo prevent both over- and undertreatment with hydrocortisone, we evaluated the prevalence of CAI in a large multicenter cohort of pediatric pts with PWS analyzing adrenal response in the low-dose ACTH test (LDAT) and/or the glucagon stimulation test (GST) and reviewing the literature.MethodsA total of 46 pts with PWS were enrolled to the study, including 34 treated with rhGH with a median dose of 0.21 mg/kg/week. LDAT was performed in 46 pts, and GST was carried out in 13 pts. Both tests were conducted in 11 pts. The tests began at 8:00 a.m. Hormones were measured by radioimmunoassays. Serum cortisol response >181.2 ng/mL (500 nmol/L) in LDAT and >199.3 ng/mL (550 nmol/L) in GST was considered a normal response. Additionally, cortisol response delta (the difference between baseline and baseline) >90 ng/mL and doubling/tripling of baseline cortisol were considered indicators of normal adrenal reserve.ResultsThree GSTs were not diagnostic (no hypoglycemia obtained). LDAT results suggested CAI in four pts, but in two out of four pts, and CAI was excluded in GST. GST results suggested CAI in only one patient, but it was excluded in LDAT. Therefore, CAI was diagnosed in 2/46 pts (4.3%), 1 treated and 1 untreated with rhGH, with the highest cortisol values of 162 and 175 ng/dL, but only in one test. However, in one of them, the cortisol delta response was >90 ng/mL and peak cortisol was more than tripled from baseline. Finally, CAI was diagnosed in one patient treated with rhGH (2.2%).ConclusionWe present low prevalence of CAI in pediatric pts with PWS according to the latest literature. Therefore, we do not recommend to routinely screen the function of the hypothalamic–pituitary–adrenal axis (HPAA) in all pts with PWS, both treated and untreated with rhGH. According to a review of the literature, signs and symptoms or low morning ACTH levels suggestive of CAI require urgent and appropriate diagnosis of HPAA by stimulation test. Our data indicate that the diagnosis of CAI should be confirmed by at least two tests to prevent overtreatment with hydrocortisone.

Abstract Background Mechanisms underpinning ARDS induced by COVID-19 are mostly immune-mediated, but need to be completely clarified. This study aimed to investigate redox balance in COVID-19 patients with ARDS, trying to recognize possible differences from typical ARDS related to the pathophysiology of severe disease. Methods Patients affected by ARDS and positive for the SARS-CoV-2 virus (N = 40, COVID-19) were compared to ARDS patients negative to the molecular test (N = 42, No COVID-19). Circulating markers of redox balance were measured in serum and erythrocytes, and related to markers of inflammation and coagulability. Results No differences in serum markers of oxidative damage were found between both groups, but a reduction in total antioxidant status and serum ceruloplasmin level was observed in COVID-19 rather than No COVID-19 patients. Redox balance alterations were described in erythrocytes from COVID-19 with respect to No COVID-19 group, characterized by increased lipofuscin and malondialdehyde concentration, and reduced glutathione S-transferase and glutathione reductase activity. These markers were associated with circulating indexes of respiratory disease severity (Horowitz index and alveolar-to-arterial oxygen gradient), inflammation (interleukin-6 and interleukin-10), and hypercoagulability (D-dimer) in COVID-19 patients with ARDS. Conclusions ARDS caused by COVID-19 is sustained by impairment of redox balance, particularly in erythrocytes. This alteration is associated with the pro-inflammatory and pro-coagulant status which characterizes severe COVID-19.

Depression is one of the most frequent mental diseases, and has a detrimental impact on numerous areas of human life. The development of depression may be fostered by various factors: genetic, biochemical, biological, mental and social. A significant role when treating depressive disorders is played by pharmacological, psychotherapeutic or cognitive and behavioral impacts. There is also evidence proving high effectiveness of properly dosed physical activity, both in the prevention and in the treatment of depressive disorders. The article is aimed at presenting the influence of regular physical activity on the improvement in emotional intelligence, in the treatment of depressive disorders. The paper is a narrative review and has been written based on the documentation analysis method, using the quantitative and the qualitative technique. The tool used was the Polish and the international scientific literature from databases, i.e. Web of Science, PubMed, Google Scholar and Europe PMC. The research material was constituted by groups of women and men, aged 9 to 80, varying in the numbers of group members. The research tools used were various psychological questionnaires, as well as magnetic resonance images. The study covered various forms of physical activity and the period of their use, while MRI was applied to assess morphological changes occurring in the brain as a result of undertaken physical activity. It was proven that regular physical training, regardless of its form, causes a reduction in stress and depression symptoms in all the respondents, notwithstanding their age and gender.

Introduction: The search for factors influencing the survival of patients with lung cancer is still ongoing. It may potentially be a polymorphism of the cleft lip and palate transmembrane 1-like (CLPTM1L) gene, which is involved in the process of carcinogenesis. The aim of the study was to assess the distribution of genotypes and alleles of selected polymorphisms of the CLPTM1L gene – rs401681 and rs402710 – in cancerous and healthy lung tissue in patients with lung adenocarcinoma and their relationship with patient survival. Material and methods: The study included 133 patients with an average age of lung cancer diagnosis of 65 years, who had undergone lung adenocarcinoma surgery in the past. Genetic material – deoxyribonucleic acid (DNA) – was isolated from paraffin-protected specimens of cancerous and healthy lung tissue, and genotyping of CLPTM1L polymorphisms was performed. The obtained results were analyzed along with demographic data, history of smoking, family history of cancer, stage of the disease in the tumor, node, metastasis (TNM) classification, clinical stage of the cancer and the survival time of the patients. Results: The mean follow-up period was 44.5 months. The patients who died lived an average of 22.6 months from the time of cancer diagnosis. There were no significant differences between the distribution of genotypes or alleles in the cancerous and healthy tissues and their relationship with the survival of the patients. The age at the time of diagnosis of cancer, category N in the TNM classification and high clinical advancement of the cancer were the only factors influencing the survival of the patients. Conclusions: No relationships between the polymorphic variability of rs401681 and rs402710 in cancerous and healthy lung tissue and the survival of patients were found.

Innovative types of dressings should manifest biodegradability and non-immunogenicity and prevent dehydration. The mentioned technological features are demonstrated by polymeric, nonwoven propolis dressings, which exhibit regenerative properties, produced with the implementation of the electrospinning method. These features are highly needed in the course of burn wound healing. To analyze the dynamics of the changes in content of glycosaminoglycans (GAGs), such as heparan sulfates and hyaluronan, a well-known protocol of burn wound healing (the Hoekstra model) was used. Burn wounds were subsequently treated with nonwoven dressings containing either 5% wt or 10% wt propolis. Control groups were treated with either a saline salt solution or nonwoven dressings without propolis. Statistical differences between groups were determined by a multivariate analysis of variance (ANOVA) and Tukey’s post hoc tests. Evaluation of the effectiveness of nonwoven dressings containing 5% wt and 10% wt propolis in healing burn wounds, based on the dynamics and concentration of GAGs, revealed apitherapeutic positive effects on injured tissue healing. This research underscores the advantageous impact of utilizing nonwoven dressings containing propolis for the treatment of burn wounds.

Background: Fear and anxiety are common psychological responses to unpleasant stimuli, with dental fear being the fourth most prevalent type of fear or phobia. However, not all dental procedures cause the same level of anxiety, with dental surgery and tooth extraction being among the top five most frightening procedures in the field. Tooth extractions are also the most common surgical procedure in dental surgery. It is important to manage anxiety in the dental office by identifying the main factors. Methods: The study was conducted on a group of 250 patients. The survey technique and the Beliefs about Pain Control Questionnaire (BPCQ) were used in the study. Pain and stress intensity on a Visual Analog Scale (VAS) were measured in each patient before and after tooth extraction procedures. Results: Young women and people from small towns had the highest levels of anxiety. The factor causing the highest level of anxiety was fear of complications. Patients undergoing extraction of retained teeth were characterized by higher levels of anxiety. Conclusions: Perioperative stress is strongly dependent on numerous factors. For patient comfort, it may be crucial for dentists to have knowledge about these factors and the ability to utilize them to reduce stress before and after tooth extractions.

Surface arthroplasty, also referred to as resurfacing, is a method of sparing hip arthroplasty, which is a surgical alternative usually reserved for younger, active patients. The introduction of successive generations of implants with metal-on-metal articulation resulted in increased interest in this method of treatment. Despite the unquestionable advantages and promising initial results, resurfacing has some limitations and disadvantages. One of them is the increase in the concentration of metal ions. Although they are necessary for the proper functioning of the human body, in large amounts they can lead to serious reactions of the soft tissues adjacent to the prosthesis, including metallosis, ALVAL (Aseptic Lyphocytic Vasculitis-Associated Lesion), or the formation of pseudotumours. Despite numerous studies and scientific reports, there is a need for further work on the relationship between the concentration levels of metal ions in people after resurfacing and the biological, causal mechanisms of the development of adverse reactions in the body.

Abstract Purpose Current epidemiological data forecast an almost 40% increase in the number of hip arthroplasty performed in the population of patients with osteoarthritis in 2060, compared to year 2018. On the basis of 10 years of observation, the failure rate after a metal-on-metal hip replacement is between 56.7 and 88.9%, depending on the used implant. Methods Seventy-six men operated using metaphyseal hip prostheses, with modular metal heads: the J&J DePuy ASR and Biomet Recap-Magnum systems, after a period of about 5–7 years after the procedure, were assessed twice (an interval of 6 months) in terms of the parameters of oxidative stress and the concentration of chromium, cobalt and ions nickel, as well as their impact on the current clinical status and quality of life. Results The mean values of the Co and Cr ion concentrations increased in a statistically significant manner at the individual stages of the study (13.20 Co and 18.16 Cr) for J&J DePuy ASR. Using the WOMAC-hip, HHS and SF-12 rating scales, the functional status of operated patients in both study groups did not change in a statistically significant manner during subsequent visits. There was a statistically significant increase in perceived pain in patients operated bilaterally with the J&J DePuy ASR system. The severity of pain could be related to the increase in the concentration of Co and Cr ions; however, it concerned a small group of bilaterally operated patients (n = 3 + n = 4). Conclusions Metal-on-metal configuration in hip arthroplasty significantly influences with the increase in the concentration of chromium and cobalt ions in a double assessment. A statistically significant increase in the concentration of the tested Co and Cr ions in the blood correlates with an increase in the intensity of pain, especially in patients undergoing bilateral surgery. The limitation of this study is the relatively small number of bilaterally operated patients. Elevated levels of Co and Cr ions in the blood of patients operated on with the J&J DePuy ASR system increased steadily during both follow-up visits.

Background/Objectives: We have previously described that low adherence to the Mediterranean diet (MD) in elderly patients admitted in internal medicine wards is linked to poorer clinical outcomes. This investigation was designed to explore whether adherence to the MD is related to circulating markers of redox balance and inflammation in this clinical scenario. Methods: A cross-sectional study was performed on 306 acute old patients hospitalized in internal medicine wards. Adherence to the MD was estimated by the Italian Mediterranean Index (IMI). The circulating markers of redox balance were assessed in serum and erythrocytes and correlated with inflammatory markers across different MD adherence groups. Results: Compared to the patients with high adherence, those with low adherence to the MD exhibited severely impaired redox balance, as evidenced by a higher GSSG/GSH ratio and increased serum hydroxynonenal/malondialdehyde–protein adducts. No modifications were described in the expression of antioxidant enzymes in peripheral blood mononuclear cells. Patients with low adherence to the MD exhibited a higher neutrophil-to-lymphocyte ratio and markers of systemic inflammation, as well as raised levels of interleukin-6 and tumor necrosis factor, compared to those with high MD adherence. A strong association was observed between the circulating markers of redox balance and inflammation/immune response, with the highest regression coefficients found in the low adherence group. Conclusions: Old patients admitted to internal medicine wards with low adherence to the MD display unfavorable profiles of the circulating markers of redox balance and inflammation. It is conceivable that such effects on redox balance can be linked to the high polyphenol content of MD. This study supports the rationale for intervention trials that attest to the effectiveness of MD as a nutritional strategy for disease prevention. [ABSTRACT FROM AUTHOR]

Natural origin products are regarded as promising for the development of new therapeutic therapies with improved effectiveness, biocompatibility, reduced side effects, and low cost of production. Betulin (BE) is very promising due to its wide range of pharmacological activities, including its anticancer, antioxidant, and antimicrobial properties. However, despite advancements in the use of triterpenes for clinical purposes, there are still some obstacles that hinder their full potential, such as their hydrophobicity, low solubility, and poor bioavailability. To address these concerns, new BE derivatives have been synthesized. Moreover, drug delivery systems have emerged as a promising solution to overcome the barriers faced in the clinical application of natural products. The aim of this manuscript is to summarize the recent achievements in the field of delivery systems of BE and its derivatives. This review also presents the BE derivatives mostly considered for medical applications. The electronic databases of scientific publications were searched for the most interesting achievements in the last ten years. Thus far, it is mostly nanoparticles (NPs) that have been considered for the delivery of betulin and its derivatives, including organic NPs (e.g., micelles, conjugates, liposomes, cyclodextrins, protein NPs), inorganic NPs (carbon nanotubes, gold NPs, silver), and complex/hybrid and miscellaneous nanoparticulate systems. However, there are also examples of microparticles, gel-based systems, suspensions, emulsions, and scaffolds, which seem promising for the delivery of BE and its derivatives.

Parkinson’s disease (PD) is one of the most common chronic neurodegenerative diseases of the central nervous system. Its most common symptoms are motor disorders. So far, no effective forms of treatment have been found, nor have any diagnostic methods been identified that would allow for diagnosis at an early stage. For this reason, clinical trials have been conducted for many years in order to find new methods of therapy which would support pharmacological treatment – and it seems that physical activity comes first here. Studies carried out on humans and animal models of PD have shown that increased physical activity improves the patterns of motor behavior and enhances the process of angiogenesis, synaptogenesis, and neurogenesis in the brain. It also increases the level of neurotrophic factors. The aim of the work was to conduct a literature review and to present the impact of physical activity on improving motor functioning in people with PD. Having people with PD take up physical activity is of preventive importance. It may also be considered an early stage of the rehabilitation process. This paper was based on the work of both Polish and foreign researchers in the following databases: Web of Science, PubMed and Google Scholar.

(1) Background: The involvement of redox balance alterations and innate immunity is suggested to play a key role in the pathogenesis of sarcopenia. This investigation aimed to define and relate modifications in circulating markers of redox homeostasis and the innate immune response in human sarcopenia. (2) Methods: A total of 32 subjects aged >65 years old and affected by sarcopenia according to the second “European Working Group on sarcopenia in older people” guidelines were compared with 40 non-sarcopenic age-matched controls. To assess systemic redox homeostasis, reduced (GSH) and oxidized (GSSG) blood glutathione and plasma malondialdehyde (MDA)– and 4-hydroxy-2,3-nonenal (HNE)–protein adducts were measured. Immune cells and circulating interleukins were determined to compare the innate immune response between both groups. (3) Results: Impaired redox balance in sarcopenic patients, characterized by a high blood GSSG/GSH ratio and plasma MDA/HNE–protein adducts, was sustained by reduced antioxidants in peripheral blood mononuclear cells. Furthermore, sarcopenic patients showed higher neutrophil-to-lymphocyte ratios and interleukin (IL)-4, IL-6, IL-10, and tumor necrosis factor (TNF) with respect to non-sarcopenic patients. Linear regression analysis resulted in a strong association between redox balance and immune response markers in the sarcopenic group. (4) Conclusions: These results support the interplay between redox homeostasis alteration and disruption of the innate immune response in the pathogenesis of sarcopenia.

In the original publication [...]

Introduction: Autism is not a specific condition. It is, however, a comprehensive disorder of psychomotor and social development. A number of factors, both environmental (family-related) and genetic, are believed to be the cause of autism. The percentage of children affected by autism has been increasing over the past 20 years. It is assumed that statistically, approximately 20 children in every 10,000 will become affected by this condition. Autism is 4 times more common in boys than in girls. The disorder is characterised by impaired mental growth, and, consequently, social and motor development.Research objective: The aim of the article is to present the role of dog therapy in supporting the process of therapeutic rehabilitation among children with autism. In particular, the following aspects were taken into account: breeds of canines used in dog therapy, mechanisms of influence concerning dog therapy on the child's body, as well as the forms and results obtained.Material and methods: The work is a narrative review. It was written on the basis of the document analysis method with the use of quantitative and qualitative techniques, as well as database searches for Polish and foreign scientific literature on the subject, i.e. Web of Science, PubMed and Google Scholar. In the article, the research results are presented in relation to the efficiency of applying dog therapy in the treatment of autistic children between 2002 and 2017, with emphasis on foreign literature.Results: The most commonly used forms of dog therapy used are: Animal Assisted Activity (AAA), Animal Assisted Therapy (AAT) and Animal Assisted Education (AAE).Conclusions: The use of dogs in the process of therapeutic rehabilitation has positive influence both on the autistic child and his/her family environment. It helps cope better with many difficulties and motivates to take up more activities. Dog therapy affects all spheres of personal development, i.e. mental, motor and socio-emotional.

Tumor cells stimulate local angiogenesis, resulting in their further multiplication and spread. Angiogenesis is a multifaceted process in which angiopoietins parti- cipate. Angiopoietin-1 (Ang-1) through its receptor Tie2 stimulates endothelial cell survival and the maintenance of the endothelial barrier. These phenomena can support tumour growth by promoting angiogenesis. On the other hand, overproduction of Ang-1 triggers endothelium stability and can lead to angiogenesis inhibition. Because of the ambiguous role of Ang-1, we decided to determine its clinical significance in patients with resectable NSCLC. In a group of 47 patients, tumours and the adjacent non-cancerous tissues were assessed for ANG-1 mRNA expression (using Q-RT-PCR analysis) and Ang-1 concentration (by enzyme-linked immunosorbent assay) together with clinical parameters and the five-year survival rate. ANG-1 expression and Ang-1 concentration were higher in tumour-free tissue, showing no differences between histological types of NSCLC, clinical stage or grading and seemed not to determine the five-year survival. ANG-1 expression and Ang-1 concentration in tumour and tumour-free tissues in patients with NSCLC seem not to be useful as factors supporting either diagnostics or prognosis.

Introduction Stress is ubiquitous and has a multidirectional impact on our health. One of the most visible problems caused by stress is sleep disturbance. The aim of the study was to evaluate the impact of subjectively assessed stress on objectively and subjectively measured sleep quality and somnolence. Material and methods 179 healthy adults aged 25–60 were examined using survey and actigraphy methods. The Epworth Sleepiness Scale (ESS), the Pittsburgh Sleep Quality Index (PSQI) and MotionWatch 8 dream recorders with MotionWare software were used. The data were analysed using Statistica 13.3 software. Results Increased sleepiness was observed in 7.8% of the population, moderate in 15.1%, poor sleep quality in 29.7%. The average intensity of stress oscillated around 3.1 pts on a 5-point scale. 27.4% had difficult and depressing problems in life, which only 45.5% of people could cope with. Stress significantly worsened the quality of sleep (PSQI) and the results of the actigraphy tests; difficult problems in life translated into a deterioration of sleep quality (PSQI), somnolence (ESS) and deterioration of the actigraphy record. The ability to cope with stress positively influenced the quality of sleep, the actigraphy record and reduced sleepiness. Conclusions Stress significantly worsens the quality of sleep, with a slight impact on daytime sleepiness. Questionnaire methods seem to be better than actigraphy to monitor the impact of stress on sleep quality. Due to the significant impact on sleep quality, it would be advisable to promote stress-coping methods as an effective method to prevent sleep disorders, especially among the working population.

Introduction Oxidative stress is one of many factors suspected to promote antinuclear autoantibody (ANA) formation. Reactive oxygen species can induce changes in the antigenic structure of macromolecules, causing the immune system to treat them as “neo-antigens” and start production of autoantibodies. This study was designed to evaluate the relationship between oxidative stress markers, lifestyle factors and the detection of ANA. Material and methods We examined measures of oxidative stress indices of free-radical damage to lipids and proteins, such as total oxidant status (TOS), concentration of protein thiol groups (PSH), and malondialdehyde (MDA), activity of superoxide dismutase (SOD) in 1731 serum samples. The parameters of the non-enzymatic antioxidant system, such as total antioxidant status (TAS) and uric acid (UA) concentration, were also measured and the oxidative stress index (OSI-index) was calculated. All samples were tested for the presence of ANA using an indirect immunofluorescence assay (IIFA). Results The presence of ANA in women was associated with lower physical activity (p = 0.036), less frequent smoking (p = 0.007) and drinking of alcohol (p = 0.024) accompanied by significant changes in SOD isoenzymes activity (p < 0.001) and a higher uric acid (UA) concentration (p < 0.001). In ANA positive males we observed lower concentrations of PSH (p = 0.046) and increased concentrations of MDA (p = 0.047). Conclusions The results indicate that local oxidative stress may be associated with increased probability of ANA formation in a sex-specific manner.

Analysis of interventions by fire protection units in road traffic incidents alerted by the eCall system between 2016 and 2022. Data from the State Fire Service Decision Support System (SFS DSS), provided by the Operational Planning Office, were used. Events from January 1, 2016, 00:00 to December 31, 2022, 23:59 were analyzed. Quantitative data were described using mean (Mean) and standard deviation (SD). Correlations and differences at a significance level of p < 0.05 were considered statistically significant. The analysis is anonymous for both victims and officers involved in the interventions. Between 2016 and 2022, firefighters were alerted by the e-call system 896 times. The shortest average intervention time was 47 ± 37 min and was recorded in 2021. In the comparative analysis of intervention time and factors conditioning the use of the eCall system, it was shown that this time was significantly statistically dependent on the number of cars involved in the incident (p < 0.001), the number of injured persons (p < 0.001), the type of intervention (p < 0.001),), and the occurrence of fuel leakage (p < 0.001). ECall is a relevant system for reporting accidents and collisions on the road. While it proves reliable in road incidents, a significantly high number of false alarms initiated from eCall requires system refinement to avoid accidental alarms and user education about the possibility of unintentionally sending an alarm signal. The authors predict that as the number of vehicles with the eCall system introduced to the roads increases, so will the number of notifications from this system. Data from the analysis of false reports suggest that mechanics and electricians in facilities performing repairs and maintenance of vehicles with the eCall system may lack the necessary knowledge of the need to deactivate the system before starting work. The number of injured people had no impact on the intervention time, which may prove that the rescue services were properly prepared. [ABSTRACT FROM AUTHOR]

Geological reservoirs are widely used for storing or disposing of various fluids and gases, including groundwater, wastewater, carbon dioxide, air, gas, and hydrogen. Monitoring these sites is essential due to the stored assets' economic value and the disposed materials' hazardous nature. Reservoir pressure monitoring is vital for ensuring operational success and detecting integrity issues, but it presents challenges due to the difficulty of obtaining comprehensive pressure distribution data. While direct pressure measurement methods are costly and localized, indirect techniques offer a viable alternative, such as inferring reservoir pressure from surface deformation data. This inversion approach integrates a forward model that links pressure distribution to deformation with an optimization algorithm to account for the ill-posed nature of the inversion. The application of forward models for predicting subsidence, uplift, and seismicity is well-established, but using deformation data for monitoring underground activity through inversion has yet to be explored. Previous studies have used various analytical, semi-analytical, and numerical models integrated with optimization tools to perform efficient inversions. However, analytical or semi-analytical solutions are impractical for complex reservoirs, and advanced numerical models are computationally expensive. These studies often rely on prior information, which may only sometimes be available, highlighting the need for innovative approaches. This study addresses these challenges by leveraging advanced numerical models and genetic algorithms to estimate pressure distribution from surface deformation data without needing prior information. The forward model is based on a discrete Green matrix constructed by integrating the finite element method with Python scripting. This matrix encapsulates the influence of reservoir properties and geometry on the displacement field, allowing for the rapid evaluation of displacement due to arbitrary pressure distributions. Precomputing Green's matrix reduces computational load, making it feasible to apply advanced optimization methods like GA, which are effective for solving ill-posed problems with fewer observation points than unknown parameters. Testing on complex reservoir cases with synthetic data showed less than 5% error in predicted pressure distribution, demonstrating the approach's reliability. [ABSTRACT FROM AUTHOR]