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128 results on '"Kashy D"'

1. High Precision Measurement of Compton Scattering in the 5 GeV region

Author

Ambrozewicz, P., Ye, L., Prok, Y., Larin, I., Ahmidouch, A., Baker, K., Baturin, V., Benton, L., Bernstein, A., Burkert, V., Clinton, E., Cole, P. L., Collins, P., Dale, D., Danagoulian, S., Davidenko, G., Demirchyan, R., Deur, A., Dolgolenko, A., Dutta, D., Dzyubenko, G., Evdokimov, A., Fedotov, G., Feng, J., Gabrielyan, M., Gan, L., Gao, H., Gasparian, A., Gevorkyan, N., Gevorkyan, S., Glamazdin, A., Goryachev, V., Guo, L., Gyurjyan, V., Hardy, K., He, J., Isupov, E., Ito, M., Jiang, L., Kang, H., Kashy, D., Khandaker, M., Kingsberry, P., Klein, F., Kolarkar, A., Konchatnyi, M., Korchin, O., Korsch, W., Kosinov, O., Kowalski, S., Kubantsev, M., Kubarovsky, A., Kubarovsky, V., Lawrence, D., Li, X., Levillain, M., Lu, H., Ma, L., Martel, P., Matveev, V., McNulty, D., Mecking, B., Micherdzinska, A., Milbrath, B., Minehart, R., Miskimen, R., Mochalov, V., Morrison, B., Mtingwa, S., Nakagawa, I., Overby, S., Pasyuk, E., Payen, M., Park, K., Pedroni, R, Phelps, W., Protopopescu, D., Rimal, D., Ritchie, B. G., Romanov, D., Salgado, C, Shahinyan, A., Sitnikov, A, Sober, D., Stepanyan, S., Stephens, W., Tarasov, V., Taylor, S., Teymurazyan, A., Underwood, J., Vasiliev, A., Vishnyakov, V., Weygand, D. P., Wood, M., Zhang, Y., Zhou, S., and Zihlmann, B.

Subjects
Nuclear Experiment, High Energy Physics - Phenomenology, Nuclear Theory
Abstract

The cross section of atomic electron Compton scattering $\gamma + e \rightarrow \gamma^\prime + e^\prime $ was measured in the 4.40--5.475 GeV photon beam energy region by the {\em PrimEx} collaboration at Jefferson Lab with an accuracy of 2\% and less. The results are consistent with theoretical predictions that include next-to-leading order radiative corrections. The measurements provide the first high precision test of this elementary QED process at beam energies greater than 0.1 GeV., Comment: 6 pages, 4 figures

Published
2019
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2. A cryostat to hold frozen-spin polarized HD targets in CLAS: HDice-II

Author

Lowry, M. M., Bass, C. D., D'Angelo, A., Deur, A., Dezern, G., Hanretty, C., Ho, D., Kageya, T., Kashy, D., Khandaker, M., Laine, V., O'Connell, T., Pastor, O., Peng, P., Sandorfi, A. M., Sokhan, D., Wei, X., and Zarecky, M.

Subjects
Physics - Instrumentation and Detectors, Nuclear Experiment
Abstract

The design, fabrication, operation, and performance of a helium-3/4 dilution refrigerator and superconducting magnet system for holding a frozen-spin polarized hydrogen deuteride target in the Jefferson Laboratory CLAS detector during photon beam running is reported. The device operates both vertically (for target loading) and horizontally (for target bombardment). The device proves capable of maintaining a base temperature of 50 mK and a holding field of 1 Tesla for extended periods. These characteristics enabled multi-month polarization lifetimes for frozen spin HD targets having proton polarization of up to 50% and deuteron up to 27%.

Published
2019
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3. The CLAS12 high threshold Cherenkov counter

Author

Sharabian, Y.G., Burkert, V.D., Biselli, A., Badui, R., Christo, S., Cuevas, C., Dong, H., Danagoulian, S., Ellis, A., Elouadrhiri, L., Eng, B., Hafidi, K., Illari, I., Jacobs, G., Joo, J., Joo, K., Kashy, D., Kubarovsky, A.V., Kubarovsky, V.P., Maiylian, S., Markov, N., McClellan, M., McMullen, M., Miller, B., Miller-Smith, S., Nickolas, D., Niyazov, R., Paremuzyan, R., Phelps, W., Popov, V., Price, J., Puckett, A., Raydo, B., Riser, D., Stoler, P., Vlassov, A., and Voskanyan, A.

Published
2020
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4. The CLAS12 superconducting magnets

Author

Fair, R., Baltzell, N., Bachimanchi, R., Biallas, G., Burkert, V.D., Campero-Rojas, P., Elementi, L., Elouadrhiri, L., Eng, B., Ghoshal, P.K., Hogan, J., Insley, D., Kashikhin, V., Kashy, D., Krave, S., Kumar, O., Laney, M., Legg, R., Lagerquist, V., Lester, M., Lemon, T., Lung, A., Luongo, C., Matalevich, J., Mestayer, M.D., Miller, R., Moore, W., Newton, J., Nobrega, F., Pastor, O., Philip, S., Rajput-Ghoshal, R., Rao Ganni, V., Rode, C., Sandoval, N., Spiegel, S., Tilles, D., Tremblay, K., Velev, G., Wilson, C., Wiseman, M., and Young, G.R.

Published
2020
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5. The CLAS12 Spectrometer at Jefferson Laboratory

Author

Burkert, V.D., Elouadrhiri, L., Adhikari, K.P., Adhikari, S., Amaryan, M.J., Anderson, D., Angelini, G., Antonioli, M., Atac, H., Aune, S., Avakian, H., Gayoso, C. Ayerbe, Baltzell, N., Barion, L., Battaglieri, M., Baturin, V., Bedlinskiy, I., Benmokhtar, F., Bianconi, A., Biselli, A.S., Bonneau, P., Bossù, F., Boyarinov, S., Briscoe, W.J., Brooks, W.K., Bruhwel, K., Carman, D.S., Celentano, A., Charles, G., Chatagnon, P., Chetry, T., Christiaens, G., Christo, S., Ciullo, G., Clary, B.A., Cole, P.L., Contalbrigo, M., Cook, M., Crede, V., Cruz-Torres, R., Cuevas, C., D’Angelo, A., Dashyan, N., Defurne, M., Deur, A., De Vita, R., Diehl, S., Djalali, C., Dodge, G., Dupre, R., Ehrhart, M., El Fassi, L., Eng, B., Ewing, T., Fair, R., Fedotov, G., Filippi, A., Forest, T.A., Garçon, M., Gavalian, G., Ghoshal, P., Gilfoyle, G.P., Giovanetti, K., Girod, F.X., Glazier, D.I., Golovatch, E., Gothe, R.W., Gotra, Y., Griffioen, K.A., Guidal, M., Gyurjyan, V., Hafidi, K., Hakobyan, H., Hanretty, C., Harrison, N., Hattawy, M., Hauenstein, F., Hayward, T.B., Heddle, D., Hemler, P., Hen, O.A., Hicks, K., Hobart, A., Hogan, J., Holtrop, M., Ilieva, Y., Illari, I., Insley, D., Ireland, D.G., Ishkhanov, B.S., Isupov, E.L., Jacobs, G., Jo, H.S., Johnston, R., Joo, K., Joosten, S., Kageya, T., Kashy, D., Keith, C., Keller, D., Khachatryan, M., Khanal, A., Kim, A., Kim, C.W., Kim, W., Kubarovsky, V., Kuhn, S.E., Lanza, L., Leffel, M., Lucherini, V., Lung, A., Kabir, M.L., Leali, M., Lee, S., Lenisa, P., Livingston, K., Lowry, M., MacGregor, I.J.D., Mandjavidze, I., Marchand, D., Markov, N., Mascagna, V., McKinnon, B., McMullen, M., Mealer, C., Mestayer, M.D., Meziani, Z.E., Miller, R., Milner, R.G., Mineeva, T., Mirazita, M., Mokeev, V., Moran, P., Movsisyan, A., Camacho, C. Munoz, Naidoo, P., Nanda, S., Newton, J., Niccolai, S., Niculescu, G., Osipenko, M., Paolone, M., Pappalardo, L.L., Paremuzyan, R., Pastor, O., Pasyuk, E., Phelps, W., Pogorelko, O., Poudel, J., Price, J.W., Price, K., Procureur, S., Prok, Y., Protopopescu, D., Rajput-Ghoshal, R., Raue, B.A., Raydo, B., Ripani, M., Ritman, J., Rizzo, A., Rosner, G., Rossi, P., Rowley, J., Roy, B.J., Sabatié, F., Salgado, C., Schadmand, S., Schmidt, A., Segarra, E.P., Sergeyeva, V., Sharabian, Y.G., Shrestha, U., Skorodumina, Iu., Smith, G.D., Smith, L.C., Sokhan, D., Soto, O., N.Sparveris, Stepanyan, S., Stoler, P., Strauch, S., Tan, J.A., Taylor, M., Tilles, D., Turisini, M., Tyler, N., Ungaro, M., Venturelli, L., Voskanyan, H., Voutier, E., Watts, D., Wei, X., Weinstein, L.B., Wiggins, C., Wiseman, M., Wood, M.H., Yegneswaran, A., Young, G., Zachariou, N., Zarecky, M., Zhang, J., Zhao, Z.W., and Ziegler, V.

Published
2020
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6. The CLAS12 forward electromagnetic calorimeter

Author

Asryan, G., Chandavar, Sh., Chetry, T., Compton, N., Daniel, A., Dashyan, N., Gevorgyan, N., Ghandilyan, Y., Giovanetti, K., Griffioen, K., Hicks, K., Kashy, D., Khachatryan, G., Khandaker, M., Phelps, W., Riso, J., Simonyan, A., Salgado, C., Smith, C., Stepanyan, S., Tang, W., Voskanyan, H., and Yurov, M.

Published
2020
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7. The Jefferson Lab Frozen Spin Target

Author

Keith, C. D., Brock, J., Carlin, C., Comer, S. A., Kashy, D., McAndrew, J., Meekins, D. G., Pasyuk, E., Pierce, J. J, and Seely, M. L.

Subjects
Physics - Instrumentation and Detectors, Nuclear Experiment
Abstract

A frozen spin polarized target, constructed at Jefferson Lab for use inside a large acceptance spectrometer, is described. The target has been utilized for photoproduction measurements with polarized tagged photons of both longitudinal and circular polarization. Protons in TEMPO-doped butanol were dynamically polarized to approximately 90% outside the spectrometer at 5 T and 200--300 mK. Photoproduction data were acquired with the target inside the spectrometer at a frozen-spin temperature of approximately 30 mK with the polarization maintained by a thin, superconducting coil installed inside the target cryostat. A 0.56 T solenoid was used for longitudinal target polarization and a 0.50 T dipole for transverse polarization. Spin-lattice relaxation times as high as 4000 hours were observed. We also report polarization results for deuterated propanediol doped with the trityl radical OX063., Comment: 11 pages, 12 figures, preprint submitted to Nuclear Instruments and Methods in Physics Research, Section A

Published
2012
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8. Design and Prototyping of a Novel Toroidal Magnet System for MOLLER Experiment at Jefferson Lab

Author

Kashy, D., Gopinath, S., Sun, E., Ghoshal, P., Fast, J., Sinnott, M., Lamont, J., Dion, M. P., Fair, R., Kumar, K., Mammei, J., Rajput-Ghoshal, R., and Ihloff, E.

Abstract

The Thomas Jefferson National Accelerator Facility (JLab) has designed a unique spectrometer system to measure the weak interaction between electrons. The experiment— Measurement of Lepton-Lepton Electroweak Reaction (MOLLER)—requires leveraging the recent 12 GeV electron beam upgrade and will run in JLab for three years. Focusing the signal for the MOLLER experiment requires five water-cooled toroidal magnets, each with unique geometry and with 7-fold symmetry. The five magnets operate in a vacuum and provide the magnetic field required to separate the incident beam electrons scattered from the target electrons (Møller scattering) and protons (elastic e-p scattering) in a liquid hydrogen target. The conceptual design was developed by the MOLLER Collaboration and was given to JLab in the form of amp turns and physical location, with additional physics requirements. This article presents prototyping of the coils and magnet support system and discusses the lessons learned during the process along with the plans for full magnet testing and installation. The JLab Magnet Group along with the MOLLER Collaboration developed the specification document that includes keep out zones to design the set of magnets. JLab contracted the design of the first toroid magnet (TM0) of the magnet system to Massachusetts Institute of Technology. The other four toroid magnets (TM1 through TM4) have been designed by JLab and are in the process of fabrication and assembly. Prototype coils of TM1-TM4 were fabricated by Everson-Tesla Incorporated, PA (USA). This article presents the unique challenges of the design, alignment, high current density, operating range, high radiation dose, and vacuum environment.

Published
2024
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9. A New Measurement of the $\pi^0$ Radiative Decay Width

Author

Larin, I., McNulty, D., Clinton, E., Ambrozewicz, P., Lawrence, D., Nakagawa, I., Prok, Y., Teymurazyan, A., Ahmidouch, A., Asratyan, A., Baker, K., Benton, L., Bernstein, A. M., Burkert, V., Cole, P., Collins, P., Dale, D., Danagoulian, S., Davidenko, G., Demirchyan, R., Deur, A., Dolgolenko, A., Dzyubenko, G., Ent, R., Evdokimov, A., Feng, J., Gabrielyan, M., Gan, L., Gasparian, A., Gevorkyan, S., Glamazdin, A., Goryachev, V., Gyurjyan, V., Hardy, K., He, J., Ito, M., Jiang, L., Kashy, D., Khandaker, M., Kingsberry, P., Kolarkar, A., Konchatnyi, M., Korchin, A., Korsch, W., Kowalski, S., Kubantsev, M., Kubarovsky, V., Li, X., Martel, P., Matveev, V., Mecking, B., Milbrath, B., Minehart, R., Miskimen, R., Mochalov, V., Mtingwa, S., Overby, S., Pasyuk, E., Payen, M., Pedroni, R., Ritchie, B., Rodrigues, T. E., Salgado, C., Shahinyan, A., Sitnikov, A., Sober, D., Stepanyan, S., Stephens, W., Underwood, J., Vasiliev, A., Vishnyakov, V., Wood, M., and Zhou, S.

Subjects
Nuclear Experiment
Abstract

High precision measurements of the differential cross sections for $\pi^0$ photoproduction at forward angles for two nuclei, $^{12}$C and $^{208}$Pb, have been performed for incident photon energies of 4.9 - 5.5 GeV to extract the ${\pi^0 \to \gamma\gamma}$ decay width. The experiment was done at Jefferson Lab using the Hall B photon tagger and a high-resolution multichannel calorimeter. The ${\pi^0 \to \gamma\gamma}$ decay width was extracted by fitting the measured cross sections using recently updated theoretical models for the process. The resulting value for the decay width is $\Gamma{(\pi^0 \to \gamma\gamma)} = 7.82 \pm 0.14 ~({\rm stat.}) \pm 0.17 ~({\rm syst.}) ~{\rm eV}$. With the 2.8% total uncertainty, this result is a factor of 2.5 more precise than the current PDG average of this fundamental quantity and it is consistent with current theoretical predictions., Comment: 4 pages, 5 figures

Published
2010
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10. Relationship Factors and Couples' Engagement in Sun Protection

Author

Manne, S. L., Coups, E. J., and Kashy, D. A.

Abstract

Individuals may be more motivated to adopt health practices if they consider the benefits of these behaviors for their close relationships. The goal of this study was to examine couple concordance with sun protection and use the interdependence and communal coping theory to evaluate the role of relationship factors in sun protection. One hundred and eighty-four married couples aged 50 years and older completed measures of objective skin cancer risk, perceived risk, sun protection benefits, relationship-centered motivations for sun protection, discussions about sun protection, and sun protection. A mediational model was evaluated. Results indicated a high level of couple concordance. Partners who adopted a relationship-centered motivation for sun protection were more likely to discuss sun protection with one another, and partners who discussed sun protection together were more likely to engage in sun protection. One partner's attitude about personal risk and sun protection benefits was associated with the other partner's sun protection. Wives had higher relationship-centered motivation and discussed sun protection more with their husbands. Behavioral interventions may benefit from encouraging couples to discuss sun protection and encouraging married individuals to consider the benefits of sun protection for their relationship and for their spouse's health.

Published
2016
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12. MOLLER Spectrometer Magnet Design With Measured Mechanical Properties of Irradiated S2-Glass Reinforced Cyanate Ester Resin at Elevated Temperature

Author

Gopinath, S., Sun, E., Frey, W., Rahman, S., Kashy, D., Dion, M., Fast, J., Fair, R., Gal, C., Ghosh, C., Kumar, K., Mammei, J., Paschke, K., Haight, A., Babcock, H., Spayde, D., Demiroglu, Z., Roshanshah, N., and Ghoshal, P. K.

Abstract

The aim of this study was to retire the risk of maintaining the integrity of S2-glass reinforced CTD-403 (a cyanate ester resin) that is exposed to radiation and elevated temperature over the life of the measurement of a lepton–lepton electroweak reaction (MOLLER) experiment in experimental Hall A at Jefferson Lab, Newport News, VA. In this article, the shear strength and flexural modulus of irradiated S2-glass reinforced CTD-403 specimens were measured at 65 °C (the magnets are to operate at less than 65 °C) under two scenarios: vacuum and gaseous nitrogen. The testing method is the short-beam shear (SBS) test according to ASTM D2344. The specimens were exposed to neutrons and gamma rays up to 124 MGy. The results show that specimens have excellent resistance against radiation, only 23% degradation of apparent shear strength with 124 MGy at 65 °C under vacuum. At the highest dose areas of the coils, tungsten plates are used to reduce the radiation dose to the resin system. The conclusion is that S2-glass reinforced CTD-403 is well-suited for electrical insulation of MOLLER magnets.

Published
2024
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14. High precision photon flux determination for photon tagging experiments

Author

Teymurazyan, A., Ahmidouch, A., Ambrozewicz, P., Asratyan, A., Baker, K., Benton, L., Burkert, V., Clinton, E., Cole, P., Collins, P., Dale, D., Danagoulian, S., Davidenko, G., Demirchyan, R., Deur, A., Dolgolenko, A., Dzyubenko, G., Ent, R., Evdokimov, A., Feng, J., Gabrielyan, M., Gan, L., Gasparian, A., Glamazdin, A., Goryachev, V., Hardy, K., He, J., Ito, M., Jiang, L., Kashy, D., Khandaker, M., Kolarkar, A., Konchatnyi, M., Korchin, A., Korsch, W., Kosinov, O., Kowalski, S., Kubantsev, M., Kubarovsky, V., Larin, I., Lawrence, D., Li, X., Martel, P., Matveev, V., McNulty, D., Mecking, B., Milbrath, B., Minehart, R., Miskimen, R., Mochalov, V., Nakagawa, I., Overby, S., Pasyuk, E., Payen, M., Pedroni, R., Prok, Y., Ritchie, B., Salgado, C., Shahinyan, A., Sitnikov, A., Sober, D., Stepanyan, S., Stevens, W., Underwood, J., Vasiliev, A., Vishnyakov, V., Wood, M., and Zhou, S.

Published
2014
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21. Relationship communication and the course of psychological outcomes among couples coping with localised prostate cancer.

Author

Heckman C.J., Kissane D.W., Kim I., Lee D., Penedo F., Manne S.L., Kashy D., Myers-Virtue S., Zaider T., Heckman C.J., Kissane D.W., Kim I., Lee D., Penedo F., Manne S.L., Kashy D., Myers-Virtue S., and Zaider T.

Abstract

OBJECTIVE: How couples communicate about cancer is an important predictor of psychological outcomes for men diagnosed with localised prostate cancer and their spouses. We examined the predictive role of disclosure, responsiveness, mutual avoidance, and holding back on depressive symptoms, psychological adjustment, cancer-specific distress, and cancer concerns. METHOD(S): Eighty-one prostate cancer patients and their spouses completed measures of communication at baseline and measures of four psychological outcomes at baseline, five, 12, and 26 weeks after baseline. Dyadic growth models tested the effects of time and role on each outcome over time. RESULT(S): Higher disclosure and responsiveness predicted better psychological outcomes. Less mutual avoidance and holding back predicted poorer psychological outcomes. Across communication variables, individuals who engaged in poorer communication initially had poorer psychological outcomes that improved over time, whereas individuals who engaged in better communication initially maintained their more positive standing without change or changed in the positive direction. For all outcomes, those with better communication still had better psychological outcomes at six months. CONCLUSION(S): Couples' cancer-specific relationship communication predicts their psychological outcomes. More research is needed to identify effective interventions, including a longer therapy course, individual communication training, or greater focus on addressing barriers to sharing and responsiveness.Copyright © 2021 John Wiley & Sons Ltd.

Published
2021

24. The CEBAF large acceptance spectrometer (CLAS)

Author

Mecking, B.A., Adams, G., Ahmad, S., Anciant, E., Anghinolfi, M., Asavapibhop, B., Asryan, G., Audit, G., Auger, T., Avakian, H., Ball, J.P., Barbosa, F.J., Barrow, S., Battaglieri, M., Beard, K., Berman, B.L., Bianchi, N., Boiarinov, S., Bonneau, P., Briscoe, W.J., Brooks, W.K., Burkert, V.D., Carman, D.S., Carstens, T., Cetina, C., Christo, S.B., Cole, P.L., Coleman, A., Connelly, J., Cords, D., Corvisiero, P., Crabb, D., Crannell, H., Cuevas, R.C., Degtyarenko, P.V., Dennis, L., DeSanctis, E., DeVita, R., Distelbrink, J., Dodge, G.E., Dodge, W., Doolittle, G., Doughty, D., Dugger, M., Duncan, W.S., Dytman, S., Egiyan, H., Egiyan, K.S., Elouadrhiri, L., Feuerbach, R.J., Ficenec, J., Frolov, V., Funsten, H., Gilfoyle, G.P., Giovanetti, K.L., Golovatch, E., Gram, J., Guidal, M., Gyurjyan, V., Heddle, D., Hemler, P., Hersman, F.W., Hicks, K., Hicks, R.S., Holtrop, M., Hyde-Wright, C.E., Insley, D., Ito, M.M., Jacobs, G., Jenkins, D., Joo, K., Joyce, D., Kashy, D., Khandaker, M., Kim, W., Klein, A., Klein, F.J., Klusman, M., Kossov, M., Kramer, L., Koubarovski, V., Kuhn, S.E., Lake, A., Lawrence, D., Longhi, A., Lukashin, K., Lachniet, J., Magahiz, R.A., Major, W., Manak, J.J., Marchand, C., Martin, C., Matthews, S.K., McMullen, M., McNabb, J.W.C., Mestayer, M.D., Minehart, R., Mirazita, M., Miskimen, R., Muccifora, V., Mueller, J., Murphy, L.Y., Mutchler, G.S., Napolitano, J., Niculescu, I., Niczyporuk, B.B., Nozar, M., O'Brien, J.T., Opper, A.K., O'Meara, J.E., Pasyuk, E., Philips, S.A., Polli, E., Price, J.W., Pozdniakov, S., Qin, L.M., Raue, B.A., Riccardi, G., Ricco, G., Riggs, C., Ripani, M., Ritchie, B.G., Robb, J., Ronchetti, F., Rossi, P., Roudot, F., Salgado, C., Sapunenko, V., Schumacher, R.A., Serov, V.S., Sharabian, Y.G., Smith, E.S., Smith, L.C., Smith, T., Sober, D.I., Stavinsky, A., Stepanyan, S., Stoler, P., Taiuti, M., Taylor, W.M., Taylor, S., Tedeschi, D.J., Thoma, U., Thompson, R., Tilles, D., Todor, L., Tung, T.Y., Tuzel, W., Vineyard, M.F., Vlassov, A.V., Weinstein, L.B., Welsh, R.E., Weygand, D.P., Wilkin, G.R., Witkowski, M., Wolin, E., Yegneswaran, A., Yergin, P., and Yun, J.

Published
2003
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25. A polarized target for the CLAS detector

Author

Keith, C.D, Anghinolfi, M, Battaglieri, M, Bosted, P, Branford, D, Bültmann, S, Burkert, V.D, Comer, S.A, Crabb, D.G, De Vita, R, Dodge, G, Fatemi, R, Kashy, D, Kuhn, S.E, Prok, Y, Ripani, M, Seely, M.L, Taiuti, M, and Witherspoon, S

Published
2003
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26. High precision measurement of Compton scattering in the 5 GeV region

Author

Ambrozewicz, P., primary, Ye, L., additional, Prok, Y., additional, Larin, I., additional, Ahmidouch, A., additional, Baker, K., additional, Baturin, V., additional, Benton, L., additional, Bernstein, A., additional, Burkert, V., additional, Clinton, E., additional, Cole, P.L., additional, Collins, P., additional, Dale, D., additional, Danagoulian, S., additional, Davidenko, G., additional, Demirchyan, R., additional, Deur, A., additional, Dolgolenko, A., additional, Dutta, D., additional, Dzyubenko, G., additional, Evdokimov, A., additional, Fedotov, G., additional, Feng, J., additional, Gabrielyan, M., additional, Gan, L., additional, Gao, H., additional, Gasparian, A., additional, Gevorkyan, N., additional, Gevorkyan, S., additional, Glamazdin, A., additional, Goryachev, V., additional, Guo, L., additional, Gyurjyan, V., additional, Hardy, K., additional, He, J., additional, Isupov, E., additional, Ito, M.M., additional, Jiang, L., additional, Kang, H., additional, Kashy, D., additional, Khandaker, M., additional, Kingsberry, P., additional, Klein, F., additional, Kolarkar, A., additional, Konchatnyi, M., additional, Korchin, O., additional, Korsch, W., additional, Kosinov, O., additional, Kowalski, S., additional, Kubantsev, M., additional, Kubarovsky, A., additional, Kubarovsky, V., additional, Lawrence, D., additional, Li, X., additional, Levillain, M., additional, Lu, H., additional, Ma, L., additional, Martel, P., additional, Matveev, V., additional, McNulty, D., additional, Mecking, B., additional, Micherdzinska, A., additional, Milbrath, B., additional, Minehart, R., additional, Miskimen, R., additional, Mochalov, V., additional, Morrison, B., additional, Mtingwa, S., additional, Nakagawa, I., additional, Overby, S., additional, Pasyuk, E., additional, Payen, M., additional, Park, K., additional, Pedroni, R., additional, Phelps, W., additional, Protopopescu, D., additional, Rimal, D., additional, Ritchie, B.G., additional, Romanov, D., additional, Salgado, C., additional, Shahinyan, A., additional, Sitnikov, A., additional, Sober, D., additional, Stepanyan, S., additional, Stephens, W., additional, Tarasov, V., additional, Taylor, S., additional, Teymurazyan, A., additional, Underwood, J., additional, Vasiliev, A., additional, Vishnyakov, V., additional, Weygand, D.P., additional, Wood, M., additional, Zhang, Y., additional, Zhou, S., additional, and Zihlmann, B., additional

Published
2019
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28. Attitudinal barriers to participation in oncology clinical trials: factor analysis and correlates of barriers

Author

MANNE, S., KASHY, D., ALBRECHT, T., WONG, Y.-N., FLAMM, A. LEDERMAN, BENSON, A. B., MILLER, S.M., FLEISHER, LINDA, BUZAGLO, J., ROACH, N., KATZ, M., ROSS, E., COLLINS, M., POOLE, D., RAIVITCH, S., MILLER, D.M., KINZY, T.G., LIU, T., and MEROPOL, N.J.

Subjects
Male, Clinical Trials as Topic, Health Knowledge, Attitudes, Practice, Decision Making, Middle Aged, Article, Cross-Sectional Studies, Neoplasms, Surveys and Questionnaires, Humans, Female, Patient Participation, Factor Analysis, Statistical, Referral and Consultation, Aged
Abstract

Patient participation in cancer clinical trials is low. Little is known about attitudinal barriers to participation, particularly among patients who may be offered a trial during an imminent initial oncology consult. The aims of the present study were to confirm the presence of proposed subscales of a recently developed cancer clinical trial attitudinal barriers measure, describe the most common cancer clinical trials attitudinal barriers, and evaluate socio-demographic, medical and financial factors associated with attitudinal barriers. A total of 1256 patients completed a survey assessing demographic factors, perceived financial burden, prior trial participation and attitudinal barriers to clinical trials participation. Results of a factor analysis did not confirm the presence of the proposed four attitudinal barriers subscale/factors. Rather, a single factor represented the best fit to the data. The most highly-rated barriers were fear of side-effects, worry about health insurance and efficacy concerns. Results suggested that less educated patients, patients with non-metastatic disease, patients with no previous oncology clinical trial participation, and patients reporting greater perceived financial burden from cancer care were associated with higher barriers. These patients may need extra attention in terms of decisional support. Overall, patients with fewer personal resources (education, financial issues) report more attitudinal barriers and should be targeted for additional decisional support.

Published
2014

36. Attitudinal barriers to participation in oncology clinical trials: factor analysis and correlates of barriers

Author

Manne, S., primary, Kashy, D., additional, Albrecht, T., additional, Wong, Y.-N., additional, Lederman Flamm, A., additional, Benson, A. B., additional, Miller, S.M., additional, Fleisher, Linda, additional, Buzaglo, J., additional, Roach, N., additional, Katz, M., additional, Ross, E., additional, Collins, M., additional, Poole, D., additional, Raivitch, S., additional, Miller, D.M., additional, Kinzy, T.G., additional, Liu, T., additional, and Meropol, N.J., additional

Published
2014
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37. HDice, Highly-Polarized Low-Background Frozen-Spin HD Targets for CLAS experiments at Jefferson Lab

Author

Wei, X, primary, Bass, C, additional, D'Angelo, A, additional, Deur, A, additional, Dezern, G, additional, Ho, D, additional, Kageya, T, additional, Khandaker, M, additional, Kashy, D, additional, Laine, V, additional, Lowry, M, additional, O'Connell, T, additional, Sandorfi, A M, additional, Teachey, R W, additional, Whisnant, C S, additional, and Zarecky, M, additional

Published
2012
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38. The Jefferson Lab frozen spin target

Author

Keith, C.D., primary, Brock, J., additional, Carlin, C., additional, Comer, S.A., additional, Kashy, D., additional, McAndrew, J., additional, Meekins, D.G., additional, Pasyuk, E., additional, Pierce, J.J., additional, and Seely, M.L., additional

Published
2012
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39. Status of Hall B Superconducting Magnets for the CLAS12 Detector at JLAB

Author

Quettier, L., primary, Burkert, V., additional, Kashy, D., additional, Elouadrhiri, L., additional, Salpietro, E., additional, Schneider, W., additional, Small, R., additional, Leung, E., additional, Juang, T., additional, McMullin, J., additional, Taylor, C., additional, Xu, L., additional, Wagner, B., additional, Wang, B., additional, Wang, M., additional, and Zbasnik, J., additional

Published
2012
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41. Preliminary Design of JLAB Clas12 Large Superconducting Torus Magnet

Author

Wang, B., primary, Wahrer, B., additional, Taylor, C., additional, Zbasnik, J., additional, Dell'Orco, D., additional, Ross, J., additional, Chen, J., additional, Xu, L., additional, Chen, H., additional, Wagner, B., additional, McMullin, J., additional, Pong, R., additional, Juang, T., additional, Wang, M., additional, Carter, C., additional, Quettier, L., additional, Burkert, V., additional, Elouadrhiri, L., additional, Kashy, D., additional, Leung, E., additional, and Schneider, W., additional

Published
2011
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42. Hall B Superconducting Magnets for the CLAS12 Detector at JLAB

Author

Quettier, L., primary, Burkert, V., additional, Elouadrhiri, L., additional, Kashy, D., additional, Leung, E., additional, Schneider, W., additional, Carter, C., additional, Chen, J., additional, Juang, T., additional, Taylor, C., additional, Xu, L., additional, Wagner, B., additional, Wahrer, B., additional, Wang, B., additional, and Wang, M., additional

Published
2011
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43. Design of a Large 5 T Superconducting Magnet for Polarized Target for JLAB Hall B 12 GeV Upgrade Clas12 Detector

Author

Wang, B., primary, Wahrer, B., additional, Taylor, C., additional, Zbasnik, J., additional, Dell'Orco, D., additional, Ross, J., additional, Chen, J., additional, Xu, L., additional, Chen, H., additional, Wagner, B., additional, McMullin, J., additional, Pong, R., additional, Juang, T., additional, Wang, M., additional, Carter, C., additional, Quettier, L., additional, Burkert, V., additional, Elouadrhiri, L., additional, Kashy, D., additional, Leung, E., additional, and Schneider, W., additional

Published
2011
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49. Abnormal Oculomotor Corollary Discharge Signaling as a Trans-diagnostic Mechanism of Psychosis.

Author

Yao B, Rolfs M, Slate R, Roberts D, Fattal J, Achtyes ED, Tso IF, Diwadkar VA, Kashy D, Bao J, and Thakkar KN

Subjects
Humans, Male, Female, Adult, Middle Aged, Saccades physiology, Visual Perception physiology, Young Adult, Psychotic Disorders physiopathology, Schizophrenia physiopathology, Bipolar Disorder physiopathology
Abstract

Background and Hypothesis: Corollary discharge (CD) signals are "copies" of motor signals sent to sensory areas to predict the corresponding input. They are a posited mechanism enabling one to distinguish actions generated by oneself vs external forces. Consequently, altered CD is a hypothesized mechanism for agency disturbances in psychosis. Previous studies have shown a decreased influence of CD signals on visual perception in individuals with schizophrenia-particularly in those with more severe positive symptoms. We therefore hypothesized that altered CD may be a trans-diagnostic mechanism of psychosis., Study Design: We examined oculomotor CD (using the blanking task) in 49 participants with schizophrenia or schizoaffective disorder (SZ), 36 bipolar participants with psychosis (BPP), and 40 healthy controls (HC). Participants made a saccade to a visual target. Upon saccade initiation, the target disappeared and reappeared at a horizontally displaced position. Participants indicated the direction of displacement. With intact CD, participants can make accurate perceptual judgements. Otherwise, participants may use saccade landing site as a proxy of pre-saccadic target to inform perception. Thus, multi-level modeling was used to examine the influence of target displacement and saccade landing site on displacement judgements., Study Results: SZ and BPP were equally less sensitive to target displacement than HC. Moreover, regardless of diagnosis, SZ and BPP with more severe positive symptoms were more likely to rely on saccade landing site., Conclusions: These results suggest that altered CD may be a trans-diagnostic mechanism of psychosis., (© The Author(s) 2024. Published by Oxford University Press on behalf of the Maryland Psychiatric Research Center.)

Published
2024
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50. CKLF instigates a "cold" microenvironment to promote MYCN-mediated tumor aggressiveness.

Author

Qin X, Lam A, Zhang X, Sengupta S, Iorgulescu JB, Ni H, Das S, Rager M, Zhou Z, Zuo T, Meara GK, Floru AE, Kemet C, Veerapaneni D, Kashy D, Lin L, Lloyd K, Kwok L, Smith KS, Nagaraju RT, Meijers R, Ceol C, Liu CT, Alexandrescu S, Wu CJ, Keskin DB, George RE, and Feng H

Subjects
Humans, Cell Line, Tumor, Gene Expression Regulation, Neoplastic, Tumor Microenvironment, Chemokines metabolism, MARVEL Domain-Containing Proteins metabolism, N-Myc Proto-Oncogene Protein metabolism, Neuroblastoma metabolism, Neuroblastoma pathology, Neuroblastoma therapy
Abstract

Solid tumors, especially those with aberrant MYCN activation, often harbor an immunosuppressive microenvironment to fuel malignant growth and trigger treatment resistance. Despite this knowledge, there are no effective strategies to tackle this problem. We found that chemokine-like factor ( CKLF ) is highly expressed by various solid tumor cells and transcriptionally up-regulated by MYCN. Using the MYCN-driven high-risk neuroblastoma as a model system, we demonstrated that as early as the premalignant stage, tumor cells secrete CKLF to attract CCR4-expressing CD4 + cells, inducing immunosuppression and tumor aggression. Genetic depletion of CD4 + T regulatory cells abolishes the immunorestrictive and protumorigenic effects of CKLF. Our work supports that disrupting CKLF-mediated cross-talk between tumor and CD4 + suppressor cells represents a promising immunotherapeutic approach to battling MYCN-driven tumors.

Published
2024
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