1. Saturated Fat Intake Is Associated with Lung Function in Individuals with Airflow Obstruction: Results from NHANES 2007–2012
- Author
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Tricia D. LeVan, Elizabeth Lyden, Kristina L. Bailey, Corrine Hanson, Kasey Cornell, Tara M. Nordgren, Morshed Alam, and Lisa Wood
- Subjects
0301 basic medicine ,Male ,Vital capacity ,saturated fat ,Saturated fat ,urologic and male genital diseases ,Gastroenterology ,Pulmonary Disease, Chronic Obstructive ,0302 clinical medicine ,Medicine ,030212 general & internal medicine ,Lung ,2. Zero hunger ,education.field_of_study ,COPD ,Nutrition and Dietetics ,medicine.diagnostic_test ,Fatty Acids ,respiratory system ,Middle Aged ,Nutrition Surveys ,3. Good health ,Respiratory Function Tests ,Quartile ,Saturated fatty acid ,Respiratory ,Female ,lcsh:Nutrition. Foods and food supply ,circulatory and respiratory physiology ,Spirometry ,Adult ,medicine.medical_specialty ,Chronic Obstructive ,Population ,lcsh:TX341-641 ,Article ,Pulmonary Disease ,lipids ,03 medical and health sciences ,FEV1/FVC ratio ,Food Sciences ,Clinical Research ,Internal medicine ,NHANES ,Humans ,education ,Nutrition ,030109 nutrition & dietetics ,business.industry ,lung function ,medicine.disease ,Dietary Fats ,respiratory tract diseases ,Diet ,stomatognathic diseases ,business ,Pulmonary Ventilation ,Food Science - Abstract
Nutritional status is a well-recognized prognostic indicator in chronic obstructive pulmonary disease (COPD), however, very little is known about the relationship between lung function and saturated fat intake. We used data from the cross-sectional National Health and Nutrition Examination Surveys (NHANES) to assess the relationship between saturated fatty acid (SFA) intake and lung function in the general US adult population. Adults in NHANES (2007–2012) with pre-bronchodilator spirometry measurements and dietary SFA intake were included. Primary outcomes were lung function including forced expiratory volume in one second (FEV1), FEV1, forced vital capacity (FVC), FEV1/FVC ratio, percent predicted FEV1 and percent predicted FVC. Multivariable regression models in the general population as well as those with spirometry-defined airflow obstruction were used to assess the relationship between lung function measurements and dietary SFA intake after adjustment for confounders. 11,180 eligible participants were included in this study. Univariate analysis revealed a statistically significant positive association between total SFA intake and lung function outcomes, however, these relationships were attenuated after adjustment for covariates. A secondary analysis of individuals with spirometry-defined airflow obstruction (FEV1/FVC <, 0.7) revealed that a lower intake of SFA was associated with reduced FEV1 (β = −126.4, p = 0.04 for quartile 1 vs. quartile 4), FVC (β = −165.8. p = 0.01 for quartile 1 vs. quartile 4), and percent predicted FVC (β = −3.3. p = 0.04 for quartile 1 vs. quartile 4), after adjustment for relevant confounders. No associations were observed for the FEV1/FVC ratio and percent predicted FEV1. It is possible that characteristics such as food source and fatty acid chain length may influence associations between saturated fatty acid intake and health outcomes.
- Published
- 2019