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Your search keyword '"Kasama, Shuhei"' showing total 20 results
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20 results on '"Kasama, Shuhei"'

3. Involvement of YKL-40-positive macrophages commonly identified in polymyositis and dermatomyositis in the pathogenesis of myositis: a retrospective study

Author

Noguchi, Kazuteru, primary, Furukawa, Tetsuya, additional, Tatsumi, Yoshiki, additional, Kasama, Shuhei, additional, Yoshikawa, Takahiro, additional, Hashimoto, Teppei, additional, Azuma, Naoto, additional, Hirota, Seiichi, additional, Kimura, Takashi, additional, and Matsui, Kiyoshi, additional

Published
2023
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4. Involvement of YKL-40-positive macrophages commonly identified in polymyositis and dermatomyositis in the pathogenesis of myositis: a retrospective study.

Author

Noguchi, Kazuteru, Furukawa, Tetsuya, Tatsumi, Yoshiki, Kasama, Shuhei, Yoshikawa, Takahiro, Hashimoto, Teppei, Azuma, Naoto, Hirota, Seiichi, Kimura, Takashi, and Matsui, Kiyoshi

Subjects
MYOSITIS, POLYMYOSITIS, MACROPHAGES, INTERSTITIAL lung diseases, DERMATOMYOSITIS, MUSCLE cells, IMMUNOHISTOCHEMISTRY
Abstract

YKL-40 is implicated in inflammation and tissue repair, but no reports have investigated its involvement in myositis in polymyositis (PM) and dermatomyositis (DM). Therefore, we aimed to investigate the relationship between YKL-40 and PM/DM. We retrospectively enrolled 35 patients diagnosed with PM/DM along with 26 healthy controls (HCs). Both PM and DM were diagnosed according to Bohan and Peter's criteria. Serum YKL-40 levels were measured, age-corrected to YKL-40 percentile values, and compared to HCs. Patients with myositis without interstitial lung disease were also enrolled and compared to HCs. Immunofluorescence staining was performed to identify YKL-40-positive inflammatory cells in muscle biopsy samples from two patients each with PM and DM. Age-corrected serum YKL-40 levels were significantly higher in patients with PM/DM compared to HCs with and without lung disease; however, these levels decreased significantly after treatment. Immunohistochemical analysis showed infiltration of YKL-40-positive inflammatory cells into the intramuscular sheath and perimuscular membrane. Immunofluorescence staining showed CD68 expression in YKL-40-positive inflammatory cells, suggesting that these cells were macrophages. To the best of our knowledge, this is the first study to demonstrate that YKL-40-positive macrophages are present in PM and DM, indicating that YKL-40 may be involved in PM/DM. [ABSTRACT FROM AUTHOR]

Published
2024
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8. P-EP028. Low-dose perampanel improves refractory cortical myoclonus by the dispersed and suppressed paroxysmal depolarization shifts in the sensorimotor cortex

Author

Oi, Kazuki, primary, Neshige, Shuichiro, additional, Hitomi, Takefumi, additional, Kobayashi, Katsuya, additional, Tojima, Maya, additional, Matsuhashi, Masao, additional, Shimotake, Akihiro, additional, Fujii, Daiki, additional, Matsumoto, Riki, additional, Kasama, Shuhei, additional, Kanda, Masutaro, additional, Wada, Yoshiaki, additional, Maruyama, Hirofumi, additional, Takahashi, Ryosuke, additional, and Ikeda, Akio, additional

Published
2021
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12. An autopsy case of amyloid β-related angiitis with cognitive impairment, multiple infarcts and subcortical hemorrhage

Author

Watanabe, Takahiro, primary, Ukon, Shinichiro, additional, Kihara, Takako, additional, Ide, Yoshi-Hiro, additional, Matsuo, Shohei, additional, Hayashi, Yuka, additional, Kasama, Shuhei, additional, Yoshikawa, Hiroo, additional, Okano, Yuki, additional, Uchida, Chiaki, additional, Yamamoto, Masahiro, additional, Hao, Hiroyuki, additional, Kimura, Akio, additional, Hirota, Seiichi, additional, and Tsukamoto, Yoshitane, additional

Published
2018
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18. Transient epileptic amnesia in a temporal lobe epilepsy patient with amygdala enlargement: a case study.

Author

Takeda, Masanaka, Kasama, Shuhei, Watanabe, Shohei, Kimura, Takashi, and Yoshikawa, Hiroo

Subjects
*AMNESIA, *AMYGDALOID body, *ANTICONVULSANTS, *COGNITION, *ELECTROENCEPHALOGRAPHY, *MAGNETIC resonance imaging, *MEMORY, *TEMPORAL lobe epilepsy
Abstract

The article describes the case of transient epileptic amnesia (TEA) in a 72-year-old patient with temporal lobe epilepsy and amygdala enlargement. Highlights include indications of accelerated forgetting reported by the patient, routine physical and neurological examinations underwent by the patient, and features in the case report that were compatible with the diagnostic criteria of TEA.

Published
2020
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19. A comparative SPECT study of regional brain perfusion in patients with Alzheimer's disease, progressive supranuclear palsy, and corticobasal degeneration

Author

Kawabata, Keita, Tachibana, Hisao, and Kasama, Shuhei

Abstract

To investigate the underlying mechanism of dementing illnesses that comprise tauopathy, we evaluated the regional cerebral blood flow (rCBF) of patients with Alzheimer's disease (AD), corticobasal degeneration (CBD), and progressive supranuclear palsy (PSP), and of normal control subjects using single-photon emission computed tomography (SPECT) with 123 I-iodoamphetamine as the tracer. rCBF was evaluated semiquantitatively by using the ratio of the RI count to the occipital region count, and the asymmetry index. Compared with the normal controls, AD patients showed significantly decreased rCBF in the inferior and lateral prefrontal, temporal, and posterior parietal cortices, while CBD patients showed significant rCBF reduction in the inferior prefrontal, anterior cingulate, medial premotor, temporal, posterior parietal, and sensorimotor cortices, thalamus, and basal ganglia. PSP patients showed no rCBF reduction in any region. Compared with PSP patients, CBD patients showed significant rCBF reduction in the sensorimotor cortex. Compared with CBD patients, AD patients showed significant rCBF reduction in the posterior parietal cortex, while rCBF in the sensorimotor cortex of the CBD patients was significantly decreased compared to the AD patients. Asymmetry of rCBF was observed in the lateral prefrontal and posterior parietal cortices of the AD patients and in the inferior prefrontal and sensorimotor cortices of the CBD patients. In conclusion, AD patients were characterized by reduced rCBF in the temporoparietal cortex. Although the magnitude of the rCBF reduction was mild in CBD, the decreases extended widely over the subcortical/cortical areas.

Published
2002
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20. Cerebral blood flow and depression in Parkinson's disease

Author

Tachibana, Hisao, Kawabata, Keita, and Kasama, Shuhei

Abstract

To clarify the responsible lesion of depression in patients with Parkinson's disease (PD), regional cerebral blood flow (rCBF) was determined and depression was evaluated in 26 patients with PD and 12 normal control subjects. Measurement of rCBF was performed by single-photon emission computed tomography (SPECT) using N -isopropyl- p [ 123 I] iodoamphetamine ( 123 I-IMP) as a tracer. Tracer activity was determined in 13 pairs of cerebellar, cortical and subcortical regions, and expressed as the ratio in each region under consideration to the mean counting rate over the cerebellar region. Assessment of the depression scale was based on the subject's performance on Zung's self-rating depression scale (SDS). There were significant differences in both the SDS and Mini-Mental State Examination (MMSE) scores between the patient and the control groups, although no correlation was noted between both scores. The SDS score in PD patients was significantly correlated with the tracer activity in the left medial and left inferior frontal cortex. Present results suggest that depression in PD may be associated with the left frontal rCBF reduction.

Published
2002
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