Tomoto Kasahara,1 Hiroshi Toshida,1 Kohei Ichikawa,1 Yusuke Matsuzaki,1 Junji Ono2 1Department of Ophthalmology, Juntendo University Shizuoka Hospital, Shizuoka, 410-2295, Japan; 2Ono Eye Clinic, Shizuoka, 410-0056, JapanCorrespondence: Hiroshi Toshida, Department of Ophthalmology, Juntendo University Shizuoka Hospital, Izunokuni, Shizuoka, 410-2295, Japan, Tel +81 55 948 3111, Fax +81 55 948 3351, Email toshida@juntendo.ac.jpAbstract: YOUSOFT is a new soft contact lens (CL) specifically designed for the correction of astigmatism. It is a conventional FDA Group II soft contact lens (SCL) and the optical zone in its centre is thick, and on its rear surface it has a prism ballast structure to prevent rotation. This lens was prescribed for a 59-year-old male on the eye with irregular corneal astigmatism after receiving penetrating keratoplasty (PKP) for refractive correction, whose eye was difficult to wear hard CLs (HCLs). After following the directions in the fitting manual provided by the manufacturer, fitting was good in the right eye and corrected visual acuity was 20/25 in Snellen Chart. He could continue wearing without CL discomfortable YOUSOFT may be useful in patients who have received PKP.Keywords: soft contact lens, irregular astigmatism, penetrating keratoplasty, keratoconus