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12 results on '"Karschimkus, Connie S"'

2. Independent euglycaemic hyperinsulinaemic clamp studies validate clinically applicable formulae to estimate insulin sensitivity in people with type 1 diabetes

Author

Januszewski, Andrzej S., primary, Niedzwiecki, Pawel, additional, Sachithanandan, Nirupa, additional, Ward, Glenn M., additional, Karschimkus, Connie S., additional, O'Neal, David N., additional, Zozulinska-Ziolkiewicz, Dorota A., additional, Uruska, Aleksandra A., additional, and Jenkins, Alicia J., additional

Published
2023
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3. Corrigendum to “Independent euglycaemic hyperinsulinaemic clamp studies validate clinically applicable formulae to estimate insulin sensitivity in people with type 1 diabetes” [Diabetes Metabol Syndr Clin Res Rev 17(1) (2023) 102691]

Author

Januszewski, Andrzej S., primary, Niedzwiecki, Pawel, additional, Sachithanandan, Nirupa, additional, Ward, Glenn M., additional, Karschimkus, Connie S., additional, O'Neal, David N., additional, Zozulinska-Ziolkiewicz, Dorota A., additional, Uruska, Aleksandra A., additional, and Jenkins, Alicia J., additional

Published
2023
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7. Longitudinal analysis of low-molecular weight fluorophores in type 1 diabetes mellitus

Author

Januszewski, Andrzej S, Thomas, Merlin C, Karschimkus, Connie S, Chung, Jasmine S, Rowley, Kevin G, Nelson, Craig L, O’Neal, David N, Dragicevic, George, Harper, Colin A, Best, James D, Jenkins, Alicia J, Januszewski, Andrzej S, Thomas, Merlin C, Karschimkus, Connie S, Chung, Jasmine S, Rowley, Kevin G, Nelson, Craig L, O’Neal, David N, Dragicevic, George, Harper, Colin A, Best, James D, and Jenkins, Alicia J

Abstract

Objectives : Circulating low molecular weight (<10 kDa) fluorophores (LMW-F) measured by non-specific fluorescence spectroscopy may detect small advanced glycation end-products (AGEs) not recognized by other assays. This longitudinal study assessed correlates of LMW-F and predictive power of LMW-F levels for vascular health in Type 1 diabetes (T1DM) patients. Methods : Fasting patients with T1DM (n=37) were studied twice at intervals of 12-60 months (mean±SD, 33±15 months). LMW-F levels were also measured once in 112 healthy control subjects. Results : Relative to controls, LMW-F levels were higher in diabetic subjects at initial and final time points (mean±SD), 5.4±1.9 AU/ml and 4.5±1.8 AU/ml respectively vs. 3.8±2.1 AU/ml p=0.0001 and p=0.06). Baseline LMW-F levels predicted subsequent hs-CRP and oxLDL/LDL values. LMW-F levels decreased significantly over time in diabetes (5.4±1.9 vs. 4.5±1.8 AU/ml p=0.02). Rises in LMW-F levels in individual diabetic subjects correlated significantly with worsening renal function (BUN), glycemia (HbA1c) and with vascular dysfunction (systemic vascular resistance). Conclusions : LMW-F levels predict levels of inflammation and oxidation in T1DM. Changes in LMW-F levels in T1DM reflect variations in glycemia and renal function. Biochemical characterization of LMW-F would facilitate understanding of the potential utility of LMW-F as a therapeutic target.

Published
2008

11. Nutritional impacts of a fruit and vegetable subsidy programme for disadvantaged Australian Aboriginal children

Author

Peter S. Morris, Connie S Karschimkus, Kerin O'Dea, Hassan Vally, Mark Daniel, Adrian Esterman, Andrew P Black, Black, Andrew P, Vally, Hassan, Morris, Peter, Daniel, Mark, Esterman, Adrian, Karschimkus, Connie S, and O'Dea, Kerin

Subjects
Male, Rural Population, Native Hawaiian or Other Pacific Islander, Adolescent, subsidy programmes, Nutritional Status, Medicine (miscellaneous), Ascorbic Acid, Xanthophylls, Vulnerable Populations, Antioxidants, Zeaxanthins, Environmental health, fruit and vegetables, Vegetables, Humans, Medicine, Food science, Healthcare Disparities, Child, Socioeconomic status, Cryptoxanthins, Nutrition and Dietetics, Cost–benefit analysis, business.industry, Aboriginal children, Lutein, Australia, Subsidy, Ascorbic acid, Carotenoids, Diet, Disadvantaged, nutrition, Child, Preschool, Fruit, Cohort, Female, Food Assistance, Rural area, business, Biomarkers, Cohort study
Abstract

Healthy food subsidy programmes have not been widely implemented in high-income countries apart from the USA and the UK. There is, however, interest being expressed in the potential of healthy food subsidies to complement nutrition promotion initiatives and reduce the social disparities in healthy eating. Herein, we describe the impact of a fruit and vegetable (F&V) subsidy programme on the nutritional status of a cohort of disadvantaged Aboriginal children living in rural Australia. A before-and-after study was used to assess the nutritional impact in 174 children whose families received weekly boxes of subsidised F&V organised through three Aboriginal medical services. The nutritional impact was assessed by comparing 24 h dietary recalls and plasma carotenoid and vitamin C levels at baseline and after 12 months. A general linear model was used to assess the changes in biomarker levels and dietary intake, controlled for age, sex, community and baseline levels. Baseline assessment in 149 children showed low F&V consumption. Significant increases (P

Published
2013

12. Longitudinal analysis of low-molecular weight fluorophores in type 1 diabetes mellitus.

Author

Januszewski AS, Thomas MC, Karschimkus CS, Chung JS, Rowley KG, Nelson CL, O'Neal DN, Dragicevic G, Harper CA, Best JD, and Jenkins AJ

Subjects
Adult, Biomarkers blood, Diabetes Mellitus, Type 1 therapy, Diabetic Angiopathies diagnosis, Diabetic Angiopathies therapy, Diabetic Nephropathies diagnosis, Diabetic Nephropathies therapy, Female, Humans, Longitudinal Studies, Male, Middle Aged, Molecular Weight, Oxidative Stress, Spectrometry, Fluorescence, Staining and Labeling, Diabetes Mellitus, Type 1 diagnosis, Glycation End Products, Advanced blood
Abstract

Objectives: Circulating low molecular weight (<10 kDa) fluorophores (LMW-F) measured by non-specific fluorescence spectroscopy may detect small advanced glycation end-products (AGEs) not recognized by other assays. This longitudinal study assessed correlates of LMW-F and predictive power of LMW-F levels for vascular health in Type 1 diabetes (T1DM) patients., Methods: Fasting patients with T1DM (n=37) were studied twice at intervals of 12-60 months (mean+/-SD, 33+/-15 months). LMW-F levels were also measured once in 112 healthy control subjects., Results: Relative to controls, LMW-F levels were higher in diabetic subjects at initial and final time points (mean+/-SD), 5.4+/-1.9 AU/ml and 4.5+/-1.8 AU/ml respectively vs. 3.8+/-2.1 AU/ml; p=0.0001 and p=0.06). Baseline LMW-F levels predicted subsequent hs-CRP and oxLDL/LDL values. LMW-F levels decreased significantly over time in diabetes (5.4+/-1.9 vs. 4.5+/-1.8 AU/ml; p=0.02). Rises in LMW-F levels in individual diabetic subjects correlated significantly with worsening renal function (BUN), glycemia (HbA1c) and with vascular dysfunction (systemic vascular resistance)., Conclusions: LMW-F levels predict levels of inflammation and oxidation in T1DM. Changes in LMW-F levels in T1DM reflect variations in glycemia and renal function. Biochemical characterization of LMW-F would facilitate understanding of the potential utility of LMW-F as a therapeutic target.

Published
2008
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