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13 results on '"Karr, Linda"'

7. Volunteering and youth services: essential readings on volunteering and volunteer management for social work, social policy and urban management

Author

Bridges Karr, Linda, Meijs, Lucas, Metz, Judith, and Lectoraat Youth Spot

Abstract

Met de transities in het sociale domein wordt van professionals gevraagd in de uitvoering van de maatschappelijke dienstverlening meer samen te werken met sociale netwerken en vrijwilligers. Internationaal is er veel bekend over het werken met vrijwilligers, maar de literatuur die hierover verschenen is wordt in Nederland nauwelijks gebruikt. Dit boek biedt een overzicht van de belangrijkste internationale publicaties over dit onderwerp en past het toe op ontwikkelingen in de jeugd- en sociale sector in Nederland.

Published
2015

8. CB1 antagonism impairs the induction of epileptiform activity by group I metabotropic glutamate receptor activation

Author

Karr, Linda, Pan, Yu-Zhen, and Rutecki, Paul A.

Subjects
Epilepsy, Dose-Response Relationship, Drug, musculoskeletal, neural, and ocular physiology, Excitatory Postsynaptic Potentials, Receptors, Metabotropic Glutamate, Synaptic Transmission, Article, Methoxyhydroxyphenylglycol, Rats, Rats, Sprague-Dawley, nervous system, Piperidines, Receptor, Cannabinoid, CB1, Animals, Pyrazoles, Rimonabant
Abstract

Exposure to the group I metabotropic glutamate receptor (mGluR) agonist dihydroxy phenylglycine (DHPG) induces epileptiform activity in the CA3 region of the hippocampus that persists following washout of DHPG. DHPG also can cause long-term depression of synaptic transmission, and at some synapses this may be mediated by endocannabinoids. We evaluated whether the selective cannabinoid type 1 (CB1) receptor antagonists SR 141716 or AM 251 could modify induction of epileptiform activity produced by DHPG exposure. The induction of epileptiform activity by DHPG exposure was significantly reduced by CB1 receptor antagonists, SR 141716 or AM 251. Minimal effects on epileptiform activity were noted once the activity had been induced. In control slices, exposure to DHPG for 30 min produced long-term depression (LTD) of synaptic transmission, on average about a 70% reduction in slope of the field excitatory postsynaptic potential (EPSP). When slices were exposed to both DHPG and SR 141716 (3 microm), LTD did not occur and the population EPSP remained at control values or greater. These results suggest that CB1 receptors mediate some of DHPG effects that result in persistent epileptiform activity, and antagonism of CB1 receptors has antiepileptogenic properties. Paradoxically DHPG also caused LTD of excitatory synaptic transmission in the CA3 region and CB1 receptor antagonism prevents the depression. We hypothesize that the ictal activity induced by DHPG requires depression of synaptic strength and CB1 receptor antagonism prevents this depression and the induction of ictal activity.

Published
2010

13. NEW HORIZONS IN CROSS-NATIONAL EXPERIMENTATION.

Author

Karr, Linda Bridges

Subjects
DYADIC analysis (Social sciences), SOCIAL exchange, COMPUTER software, SOCIAL science research
Abstract

This study demonstrates the feasibility of a previously unutilized format for social research in a cross-national context. Dyadic exchange experiments were conducted with internet-based experimental software, using subjects physically located in the United States and the Netherlands. In this study, I discuss issues regarding cross-national experimentation, provide an overview of Elementary Theory and its predictions for dyadic exchange, and present the results of a unique experimental setting, along with a detailed description of the methods used to conduct the study. Results indicate that the resistance predictions of Elementary Theory hold irrespective of national boundaries. [ABSTRACT FROM AUTHOR]

Published
2000

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