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Your search keyword '"Karpov, Andrei A."' showing total 23 results
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23 results on '"Karpov, Andrei A."'

4. Caracteristiques de depart et issues chez des patients atteints de COVID-19 hospitalises dans des unites de soins intensifs a Vancouver (Canada) : serie de cas

Author

Mitra, Anish R., Fergusson, Nicholas A., Lloyd-Smith, Elisa, Wormsbecker, Andrew, Foster, Denise, Karpov, Andrei, Crowe, Sarah, Haljan, Greg, Chittock, Dean R., Kanji, Hussein D., Sekhon, Mypinder S., and Griesdale, Donald E.G.

Subjects
Statistics, Patient outcomes, Mortality -- Statistics -- Canada, Coronaviruses, Intensive care nursing -- Statistics -- Patient outcomes, COVID-19 -- Statistics -- Patient outcomes
Abstract

Le coronavirus du syndrome respiratoire aigu severe 2 (SRAS-CoV-2) est responsable de la maladie a coronavirus 2019 (COVID-19), qui a maintenant le statut de pandemie selon l'Organisation mondiale de la [...], CONTEXTE : La pandemie de maladie a coronavirus du syndrome respiratoire aigu severe 2 (SRAS-CoV-2) est associee a une mortalite elevee dans les unites de soins intensifs (USI). Nous avons voulu decrire les caracteristiques cliniques et les issues des patients gravement atteints de la maladie a coronavirus 2019 (COVID-19) en contexte canadien. METHODES : Nous avons procede a l'etude retrospective d'une serie de cas graves d'infection au SRAS-CoV-2 confirmee en laboratoire hospitalises dans l'une des 6 USI du Vancouver metropolitain, en Colombie-Britannique (Canada), entre le 21 fevrier et le 14 avril 2020. Les donnees demographiques, les renseignements sur la prise en charge et les resultats ont ete recueillis a partir des dossiers medicaux, electroniques ou non, des patients. RESULTATS : Entre le 21 fevrier et le 14 avril 2020, 117 patients ont ete admis dans une USI avec un diagnostic confirme de COVID-19. L'age median etait de 69 ans (ecart interquartile [EI] 60-75 ans); et 38 (32,5 %) etaient des femmes. Au moins une comorbidite etait presente chez 86 patients (73,5 %). La ventilation mecanique a ete necessaire chez 74 patients (63,2 %). La duree de la ventilation mecanique a ete de 13,5 jours (EI 8-22 jours) dans l'ensemble et de 11 jours (II 6-16) chez les patients qui ont recu leur conge de l'USI. Du tocilizumab a ete administre a 4 patients et de l'hydroxychloroquine a 1 patient. En date du 5 mai 2020, 18 patients (15,4 %) etaient decedes, 12 (10,3 %) etaient toujours a l'USI, 16 (13,7 %) avaient obtenu leur conge de l'USI, mais restaient hospitalises, et 71 (60,7 %) avaient pu retourner a la maison. INTERPRETATION : Dans cette etude, la mortalite chez les patients gravement malades de la COVID-19 hospitalises dans une USI a ete moins elevee que chez les patients d'etudes precedentes. Ces resultats donnent a penser que le pronostic des cas graves de COVID-19 pourrait ne pas etre aussi sombre que ce qui avait d'abord ete rapporte.

Published
2020
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5. Baseline characteristics and outcomes of patients with COVID-19 admitted to intensive care units in Vancouver, Canada: a case series

Author

Mitra, Anish R., Fergusson, Nicholas A., Lloyd-Smith, Elisa, Wormsbecker, Andrew, Foster, Denise, Karpov, Andrei, Crowe, Sarah, Haljan, Greg, Chittock, Dean R., Kanji, Hussein D., Sekhon, Mypinder S., and Griesdale, Donald E.G.

Subjects
Patient outcomes, Mortality -- China -- British Columbia -- Canada, Severe acute respiratory syndrome -- Patient outcomes, Medical records, Coronaviruses, COVID-19 -- Patient outcomes
Abstract

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causes coronavirus disease 2019 (COVID-19), now characterized as a pandemic by the World Health Organization. (1) Infection rates and deaths worldwide increased exponentially. [...], BACKGROUND: Pandemic severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is associated with high intensive care unit (ICU) mortality. We aimed to describe the clinical characteristics and outcomes of critically ill patients with coronavirus disease 2019 (COVID-19) in a Canadian setting. METHODS: We conducted a retrospective case series of critically ill patients with laboratory-confirmed SARS-CoV-2 infection consecutively admitted to 1 of 6 ICUs in Metro Vancouver, British Columbia, Canada, between Feb. 21 and Apr. 14, 2020. Demographic, management and outcome data were collected by review of patient charts and electronic medical records. RESULTS: Between Feb. 21 and Apr. 14, 2020, 117 patients were admitted to the ICU with a confirmed diagnosis of COVID-19. The median age was 69 (interquartile range [IQR] 60-75) years, and 38 (32.5%) were female. At least 1 comorbidity was present in 86 (73.5%) patients. Invasive mechanical ventilation was required in 74 (63.2%) patients. The duration of mechanical ventilation was 13.5 (IQR 8-22) days overall and 11 (IQR 6-16) days for patients successfully discharged from the ICU. Tocilizumab was administered to 4 patients and hydroxychloroquine to 1 patient. As of May 5, 2020, a total of 18 (15.4%) patients had died, 12 (10.3%) remained in the ICU, 16 (13.7%) were discharged from the ICU but remained in hospital, and 71 (60.7%) were discharged home. INTERPRETATION: In our setting, mortality in critically ill patients with COVID-19 admitted to the ICU was lower than in previously published studies. These data suggest that the prognosis associated with critical illness due to COVID-19 may not be as poor as previously reported.

Published
2020
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7. Sympathetic Denervation and Pharmacological Stimulation of Parasympathetic Nervous System Prevent Pulmonary Vascular Bed Remodeling in Rat Model of Chronic Thromboembolic Pulmonary Hypertension

Author

Karpov, Andrei, primary, Vachrushev, Nikita, additional, Shilenko, Leonid, additional, Smirnov, Sergey, additional, Bunenkov, Nikolay, additional, Butskih, Maxim, additional, Chervaev, Al-Khalim, additional, Vaulina, Dariya, additional, Ivkin, Dmitry, additional, Moiseeva, Olga, additional, and Galagudza, Michael, additional

Published
2023
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8. Inhibition of JAK1,2 Prevents Fibrotic Remodeling of Pulmonary Vascular Bed and Improves Outcomes in the Rat Model of Chronic Thromboembolic Pulmonary Hypertension

Author

Karpov, Andrei A., primary, Mihailova, Aleksandra M., additional, Shilenko, Leonid A., additional, Vaulina, Dariya D., additional, Sidorova, Elizaveta E., additional, Akhmetova, Anna A., additional, Docshin, Pavel M., additional, Krasichkov, Alexander S., additional, Sanarova, Kseniia E., additional, Moiseeva, Olga M., additional, and Galagudza, Michael M., additional

Published
2022
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10. A new transcriptional role for matrix metalloproteinase-12 in antiviral immunity

Author

Marchant, David J., Bellac, Caroline L., Moraes, Theo J., Wadsworth, Samuel J., Dufour, Antoine, Butler, Georgina S., Bilawchuk, Leanne M., Hendry, Reid G., Robertson, A. Gordon, Cheung, Caroline T., Ng, Julie, Ang, Lisa, Luo, Zongshu, Heilbron, Karl, Norris, Michael J., Duan, Wenming, Bucyk, Taylor, Karpov, Andrei, Devel, Laurent, Georgiadis, Dimitris, Hegele, Richard G., Luo, Honglin, Granville, David J., Dive, Vincent, McManus, Bruce M., and Overall, Christopher M.

Subjects
Analysis, Physiological aspects, Research, Immunity (Physiology) -- Research -- Analysis, Proteases -- Research -- Analysis -- Physiological aspects, Immunity -- Research -- Analysis
Abstract

Interferons (1) and macrophages are important in antiviral immunity (2). MMP-12 (ref. 3; also known as macrophage metalloelastase) is a secreted protease that degrades extra cellular matrix during inflammatory tissue [...], Interferon-α (IFN-α) is essential for antiviral immunity, but in the absence of matrix metalloproteinase-12 (MMP-12) or IκBα (encoded by NFKBIA) we show that IFN-α is retained in the cytosol of virus-infected cells and is not secreted. Our findings suggest that activated IκBα mediates the export of IFN-α from virus-infected cells and that the inability of cells in [Mmp12.sup.-/-] but not wild-type mice to express IκBα and thus export IFN-α makes coxsackievirus type B3 infection lethal and renders respiratory syncytial virus more pathogenic. We show here that after macrophage secretion, MMP-12 is transported into virus-infected cells. In HeLa cells MMP-12 is also translocated to the nucleus, where it binds to the NFKBIA promoter, driving transcription. We also identified dual-regulated substrates that are repressed both by MMP-12 binding to the substrate's gene exons and by MMP-12-mediated cleavage of the substrate protein itself. Whereas intracellular MMP-12 mediates NFKBIA transcription, leading to IFN-α secretion and host protection, extra cellular MMP-12 cleaves off the IFN-α receptor 2 binding site of systemic IFN-α, preventing an unchecked immune response. Consistent with an unexpected role for MMP-12 in clearing systemic IFN-α, treatment of coxsackievirus type B3-infected wild-type mice with a membrane-impermeable MMP-12 inhibitor elevates systemic IFN-α levels and reduces viral replication in pancreas while sparing intracellular MMP-12. These findings suggest that inhibiting extra cellular MMP-12 could be a new avenue for the development of antiviral treatments.

Published
2014
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11. Two-step propagation for the numerical reconstruction of holographic image.

Author

Fedorov, Arthur G., Trofimov, Vasiliy V., and Karpov, Andrei G.

Subjects
HOLOGRAPHY, IMAGE reconstruction, IMPULSE response, FAST Fourier transforms, FOURIER integrals, SIGNAL convolution
Abstract

In-line holography (holography of Gabor) is a simple and effective method of holographic investigation of the structure of objects. The computer simulation of holographic images is based on the numerical solution of Fresnel integrals with fast Fourier transform algorithms. We propose a new method for the numerical reconstruction of holographic image. This new method is based on two-step propagation. The two-step propagation method is described for the case of a fixed and relatively arbitrary choice of the sampling grid in the object and observation planes. There are have many ways to computer simulation of two-step propagation. In this paper simulate based on convolution signal with a transfer function of impulse response. [ABSTRACT FROM AUTHOR]

Published
2022
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15. Theoretical basics of applying the one dimensional problem of soils compression seal theory to large foundation plates calculation

Author

Isaev Veniamin, Maltsev Andrei, and Karpov Andrei

Subjects
Engineering (General). Civil engineering (General), TA1-2040
Abstract

Calculation of compressed footings settlement is one of the most vital tasks of soil mechanics. The calculation method of layer-by-layer addition, which recommended by current regulations and used in structural engineering practice, is most suitable for determining the settlement of foundations with an area of less than 50 m2. The authors prove that it’s possible to apply the one-dimensional problem of soils compression seal theory to the calculation of the settlement of large foundation plates. The proposed method of determining the settlement of large foundation plates makes the calculations simpler. There are examples of comparable calculations using the existing and proposed methods.

Published
2016
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16. Model of Chronic Thromboembolic Pulmonary Hypertension in Rats Caused by Repeated Intravenous Administration of Partially Biodegradable Sodium Alginate Microspheres

Author

Karpov, Andrei A., primary, Anikin, Nikita A., additional, Mihailova, Aleksandra M., additional, Smirnov, Sergey S., additional, Vaulina, Dariya D., additional, Shilenko, Leonid A., additional, Ivkin, Dmitry Yu., additional, Bagrov, Alexei Y., additional, Moiseeva, Olga M., additional, and Galagudza, Michael M., additional

Published
2021
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19. Performance of trigger tools in identifying adverse drug events in emergency department patients: a validation study

Author

Karpov, Andrei, Parcero, Catherine, Mok, Catherine P.Y., Panditha, Chandima, Yu, Eugenia, Dempster, Linda, and Hohl, Corinne M.

Subjects
Male, Observer Variation, Drug Safety, Drug-Related Side Effects and Adverse Reactions, Point-of-Care Systems, Humans, Medication Errors, Female, Prospective Studies, Middle Aged, Emergency Service, Hospital, Sensitivity and Specificity, Algorithms
Abstract

Trigger tools are retrospective surveillance methods that can be used to identify adverse drug events (ADEs), unintended and harmful effects of medications, in medical records. Trigger tools are used in quality improvement, public health surveillance and research activities. The objective of the study was to evaluate the performance of trigger tools in identifying ADEs.This study was a sub-study of a prospective cohort study which enrolled adults presenting to one tertiary care emergency department. Clinical pharmacists evaluated patients for ADEs at the point-of-care. Twelve months after the prospective study's completion, the patients' medical records were reviewed using eight different trigger tools. ADEs identified using each trigger tool were compared with events identified at the point-of-care. The primary outcome was the sensitivity of each trigger tool for ADEs.Among 1151 patients, 152 (13.2%, 95% confidence intervals (CI) 11.4, 15.3%) were diagnosed with one or more ADEs at the point-of-care. The sensitivity of the trigger tools for detecting ADEs ranged from 2.6% (95% CI 0.7, 6.6%) to 15.8% (95% CI 10.6, 22.8%). Their specificity varied from 99.3% (95% CI 98.6, 99.7) to 100% (95% CI 99.6, 100%).The trigger tools examined had poor sensitivity for identifying ADEs in emergency department patients, when applied manually and in retrospect. Reliance on these methods to detect ADEs for quality improvement, surveillance, and research activities is likely to underestimate their occurrence, and may lead to biased estimates.

Published
2016

22. Identification of HI-Like Loop in CELO Adenovirus Fiber for Incorporation of Receptor Binding Motifs

Author

Logunov, Denis Y., primary, Zubkova, Olga V., additional, Karyagina-Zhulina, Anna S., additional, Shuvalova, Eugenia A., additional, Karpov, Andrei P., additional, Shmarov, Maxim M., additional, Tutykhina, Irina L., additional, Alyapkina, Yulia S., additional, Grezina, Natalia M., additional, Zinovieva, Natalia A., additional, Ernst, Lev K., additional, Gintsburg, Alexsandr L., additional, and Naroditsky, Boris S., additional

Published
2007
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23. The Multiple Paths to a Career in Emergency Medicine.

Author

Karpov, Andrei and Agha, Maurice

Subjects
*EMERGENCY medicine, *MEDICINE, *INTERNSHIP programs, *NONPROFIT organizations, *GENERAL practitioners, *EDUCATION, *HIGHER education, *SOCIETIES
Abstract

The article discusses several options for a career in Canadian emergency medicine (EM). The two approaches to EM training include a five-year EM Residency Program via the Royal College of Physicians and Surgeons of Canada (RCPSC) and a one-year EM Certificate Program plus two-year Family Medicine Residency via the Canadian College of Family Physicians (CCFP). Brian Chung of the CCFP says the programs are aimed at addressing various niches within the EM field.

Published
2012

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