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Hydrological models are vital for water management to determine in-stream flow, irrigational water, domestic water supply, and biodiversity conservation. This study formulates a hydrological model with a novel approach for streamflow and sediment load in the QGIS-supported Soil and Water Assessment Tool for the Halda River catchment, a unique ecological habitat for natural carp spawning and freshwater sources. The daily simulation uses an innovative stage-discharge relationship technique from available 15-day interval flow data. The model evaluation parameters R2 values 0.80 and 0.62, and NS values 0.81 and 0.61 for calibration and validation of streamflow suggested excellent agreement in the seasonal cycle and most of the monsoon peak flow. The streamflow/precipitation ratio indicates a significant influence of groundwater through infiltration. The baseflow shows a decreasing trend. The sediment load based on suspended sediment concentration at a downstream location is 1,625 tons/day. On the contrary, the model prediction is 30 times lower. The scattered sediment load data support the model estimate by considering relatively lower intervention or land use change in its upstream. This model provides a baseline for daily flow and sediment load for scenario modeling (e.g., climate change, land use change) for environmental flow estimation of the fish habitat, freshwater supply, irrigation, and salinity intrusion. [ABSTRACT FROM AUTHOR]

Rare genetic diseases (RGDs) affect a small percentage of the global population but collectively have a substantial impact due to their diverse manifestations. Although the precise reasons behind these diseases remain unclear, roughly 80% of cases are genetically linked. Recent efforts focus on understanding pathology and developing new diagnostic and therapeutic approaches for RGDs. However, there persists a gap between fundamental research and clinical therapeutic approaches, where advancements in nanotechnology offer promising improvements. In this context, nanosized light-emitting quantum dots (QDs), ranging from 2-10 nm, are promising materials for diverse applications. Their size-tunable light emission, high quantum yield, and photostability allow for precise tracking of cargo. Additionally, QDs can be functionalized with therapeutic agents, antibodies, or peptides to target specific cellular pathways, enhancing treatment efficacy while minimizing side effects. By combining diagnostic and therapeutic capabilities in a single platform, QDs thus offer a versatile and powerful approach to tackle rare genetic disorders. Despite several reviews on various therapeutic applications of QDs, their utilization in the specific domain of RGDs is not well documented. This review highlight QDs' potential in diagnosing and treating certain RGDs and addresses the challenges limiting their application., (© 2025 Wiley‐VCH GmbH.)