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28 results on '"Karlaftis, Vasiliki"'

2. Continuous reference intervals for holotranscobalamin, homocysteine and folate in a healthy paediatric cohort.

Author

Smith, Joel D, Karlaftis, Vasiliki, Hearps, Stephen, Attard, Chantal, Savoia, Helen, Campbell, Janine, and Monagle, Paul

Subjects
*ERYTHROCYTES, *DIET therapy, *HOMOCYSTEINE, *ADULTS, *ADOLESCENCE, *FOLIC acid
Abstract

Background: The detection of deficiencies in B12 and folate children is important. However, despite the availability of various markers to assess B12 and folate metabolism, there are limited studies describing the reference intervals (RIs) and changes during growth and development for these markers in healthy children. Methods: Using samples collected from 378 children aged 30 days–< 18 years, we derived continuous RIs for holotranscobalamin, homocysteine and red cell folate. Results: The lower RI for holotranscobalamin was lowest at birth, rising during early childhood and then declining following ages 4–6 years whereas red cell folate was highest early in life and then declined steadily towards adulthood. Total homocysteine, reflective of both B12 and folate status was elevated early in life, reaching a nadir at age 2 and then increasing towards adulthood. Conclusions: Continuous central 95th percentile RI for holotranscobalamin, homocysteine and red cell folate for children ages 30 days to <18 years were established. Each marker shows dynamic changes throughout childhood and adolescence which will assist clinicians in more appropriately assessing B12 and folate status in this population. [ABSTRACT FROM AUTHOR]

Published
2024
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3. Reference intervals for serum cystatin C in neonates and children 30 days to 18 years old

Author

Cai, Tengyi, Karlaftis, Vasiliki, Hearps, Stephen, Matthews, Susan, Burgess, Janet, Monagle, Paul, and Ignjatovic, Vera

Subjects
Children -- Diseases, Kidney function tests -- Demographic aspects, Infants (Newborn) -- Medical examination, Health
Abstract

Background Serum cystatin C (CysC) is a promising biomarker of kidney function, which has higher accuracy and sensitivity when compared with creatinine. To better utilize serum CysC in clinical practice, this study aimed to establish continuous paediatric reference intervals (RIs) for serum CysC. Methods The study subjects consisted of healthy term neonates and children aged 30 days to 18 years. Venous blood samples were collected and serum CysC levels were measured using the immunoturbidimetric measurement principle. Fractional polynomial regression model and quantile regression was applied in the statistical analysis to generate continuous RIs. Results A total of 378 samples with equal numbers of males and females were analysed for serum CysC. No outliers were found in this analysis. The continuous RIs are presented as equations and graphical scatterplots. Conclusions This study established continuous paediatric reference intervals (RIs) for serum CysC in healthy term neonates and children. The continuous RIs generated from this study show age-based dynamic changes as well as blood group and gender-specific differences for serum CysC., Author(s): Tengyi Cai [sup.1] , Vasiliki Karlaftis [sup.1] , Stephen Hearps [sup.1] , Susan Matthews [sup.3] , Janet Burgess [sup.3] , Paul Monagle [sup.1] [sup.2] [sup.3] , Vera Ignjatovic [sup.1] [...]

Published
2020
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4. Changes in von Willebrand Factor Multimers, Concentration, and Function During Pediatric Extracorporeal Membrane Oxygenation*

Author

Van Den Helm, Suelyn, primary, Letunica, Natasha, additional, Barton, Rebecca, additional, Weaver, Asami, additional, Yaw, Hui Ping, additional, Karlaftis, Vasiliki, additional, McCafferty, Conor, additional, Cai, Tengyi, additional, Newall, Fiona, additional, Horton, Stephen B., additional, Chiletti, Roberto, additional, Johansen, Amy, additional, Best, Derek, additional, McKittrick, Joanne, additional, Butt, Warwick, additional, d’Udekem, Yves, additional, MacLaren, Graeme, additional, Linden, Matthew D., additional, Ignjatovic, Vera, additional, and Monagle, Paul, additional

Published
2023
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8. Fibrin clot characteristics and anticoagulant response in a SARS‐CoV‐2‐infected endothelial model

Author

McCafferty, Conor, primary, Lee, Leo, additional, Cai, Tengyi, additional, Praporski, Slavica, additional, Stolper, Julian, additional, Karlaftis, Vasiliki, additional, Attard, Chantal, additional, Myint, David, additional, Carey, Leeanne M., additional, Howells, David W., additional, Donnan, Geoffrey A., additional, Davis, Stephen, additional, Ma, Henry, additional, Crewther, Sheila, additional, Nguyen, Vinh A., additional, Van Den Helm, Suelyn, additional, Letunica, Natasha, additional, Swaney, Ella, additional, Elliott, David, additional, Subbarao, Kanta, additional, Ignjatovic, Vera, additional, and Monagle, Paul, additional

Published
2022
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9. Proteomics in Thrombosis and Hemostasis

Author

Letunica, Natasha, additional, Van Den Helm, Suelyn, additional, McCafferty, Conor, additional, Swaney, Ella, additional, Cai, Tengyi, additional, Attard, Chantal, additional, Karlaftis, Vasiliki, additional, Monagle, Paul, additional, and Ignjatovic, Vera, additional

Published
2021
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11. Increased platelet activation in SARS‐CoV‐2 infected non‐hospitalised children and adults, and their household contacts

Author

McCafferty, Conor, primary, Van Den Helm, Suelyn, additional, Letunica, Natasha, additional, Attard, Chantal, additional, Karlaftis, Vasiliki, additional, Cai, Tengyi, additional, Praporski, Slavica, additional, Swaney, Ella, additional, Burgner, David, additional, Neeland, Melanie, additional, Dohle, Kate, additional, Crawford, Nigel W., additional, Clucas, Luisa, additional, Tosif, Shidan, additional, Ignjatovic, Vera, additional, and Monagle, Paul, additional

Published
2021
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