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Your search keyword '"Karla Ceodaro Pais"' showing total 2 results
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2 results on '"Karla Ceodaro Pais"'

1. Oxidação do borneol à cânfora com água sanitária - um experimento simples, de baixo custo e limpo Oxidation of borneol to camphor with bleach: a simple, green chemistry and inexpensive experiment

Author

Ana Paula Bernardo dos Santos, Idila Rafaela Carvalho Gonçalves, Karla Ceodaro Pais, Sabrina Teixeira Martinez, Elizabeth Roditi Lachter, and Angelo C. Pinto

Subjects
oxidation, borneol, bleach, Chemistry, QD1-999
Abstract

Regulatory pressure is increasingly focusing on the use and disposal of substances hazardous to human health and environment. In the last years efforts have also been made to introduce green chemistry concepts in undergraduate courses. In this paper we present an experiment on the oxidation reaction of borneol to camphor with bleach in acetone. This experiment is important to show undergraduate students that a cheap and non hazardous commercial product can be a useful oxidation agent of alcohols.

Published
2009
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2. In vivo and in vitro antimalarial effect and toxicological evaluation of the chloroquine analogue PQUI08001/06

Author

Patrícia T. Bozza, Valber da Silva Frutuoso, Natália Ferreira Costa, Carlos R. Kaiser, Bruno Douradinha, Karla Ceodaro Pais, Mariano G. Zalis, Marcos V. N. de Souza, Patrícia A. Reis, Marcelle de Lima Ferreira, Monica Farah Pereira, André Luiz Lisboa Areas, and Hugo C. Castro-Faria-Neto

Subjects
Male, 0301 basic medicine, Plasmodium berghei, Plasmodium falciparum, 030231 tropical medicine, Drug Resistance, Drug resistance, Parasitemia, Pharmacology, Antimalarials, Mice, 03 medical and health sciences, 0302 clinical medicine, In vivo, Chloroquine, parasitic diseases, medicine, Animals, Humans, General Veterinary, biology, General Medicine, biology.organism_classification, medicine.disease, In vitro, Malaria, 030104 developmental biology, Infectious Diseases, Parasitology, Insect Science, medicine.drug
Abstract

Antimalarial interventions mostly rely upon drugs, as chloroquine. However, plasmodial strains resistant to many drugs are constantly reported, leading to an expansion of malaria cases. Novel approaches are required to circumvent the drug resistance issue. Here, we describe the antimalarial potential of the chloroquine analogue 2-[[2-[(7-chloro-4-quinolinyl)amino]ethyl]amino] ethanol (PQUI08001/06). We observed that PQUI08001/06 treatment reduces parasitemia of both chloroquine-resistant and -sensitive strains of Plasmodium falciparum in vitro and P. berghei in vivo. Our data suggests that PQUI08001/06 is a potential antimalarial therapeutic alternative approach that could also target chloroquine-resistant plasmodial strains.

Published
2018

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