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1. Characteristics and outcomes of SARS-CoV-2 breakthrough infections among double-vaccinated and triple-vaccinated patients with inflammatory rheumatic diseases

Author

Tobias Alexander, Hendrik Schulze-Koops, Ulf Müller-Ladner, Rebecca Fischer-Betz, Martin Aringer, Rieke Alten, Petra Saar, Tim Schmeiser, Marina Backhaus, Stephanie Finzel, Cornelia Glaser, Hildrun Haibel, Hanns-Martin Lorenz, Gamal Chehab, Christof Specker, Reinhard E Voll, Anja Strangfeld, Norbert Blank, Matthias Braun, Alexander Pfeil, Rebecca Hasseli, Andreas Krause, Anne Constanze Regierer, Peer Aries, Ioana Andreica, Jacqueline Detert, Elvira Decker, Urs Hartmann, Joerg Henes, Kirsten de Groot, JOACHIM GEORGI, Hans Bastian, Christoph Fiehn, Martin Feuchtenberger, Martin Fleck, Christian Blum, Mathias Grunke, Martin Bohl-Bühler, Georg Gauler, Bimba Franziska Hoyer, Guido Hoese, Janine Günther, Matthias Braunisch, Jutta G. Richter, Sabine Reckert, Anett Gräßler, Andreas Kapelle, Silke Osiek, Anna Knothe, Jan Brandt-Jürgens, Anja Maltzahn, Fredrik Albach, Annette Alberding, Susanne Aman, Christopher Amberger, Michaela Amberger, Bianka Andermann, Nils Anders, Jan Andresen, Nikolaos Andriopoulos, Elizabeth Arauj, Uta Arndt, Sarah Avemarg, Christoph Baerwald, Erich Bärlin, Nora Bartholomä, Michael Bäuerle, Jutta Bauhammer, Christine Baumann, Klaus Becker, Heidemarie Becker, Michaela Bellm, Sylvia Berger, Andrea Berghofen, Gerhard Birkner, Daniel Blendea, Hans Bloching, Sebastian Blötz, Stephanie Boeddeker, Susanne Bogner, Lara Bohnen, Ilka Bösenberg, Nicole Böttcher, Diana Braun, Jan Philipp Bremer, Matthias Broll, Andreas Bruckner, Veronika Brumberger, Martin Brzank, Sahra Büllesfeld, Sandra Burger, Michaela Christenn, Anne Claußnitzer, Frank Demtröder, Rainer Dörfler, Elke Drexler, Valeria Dudics, Edmund Edelmann, Roman Eder, Christina Eisterhues, Joachim Michael Engel, Brigitte Erbslöh-Möller, Miriam Feine, Samantha Ferdinan, Claudia Franke, Stefanie Freudenberg, Christian Fräbel, Petra Fuchs, Regina Gaissmaier, Ino Gao, Oliver Gardt, Katrin Geißler, Karolina Gente, Jasmin Gilly, Yannik Gkanatsas, Agnes Gniezinski- Schwister, Rahel Gold, Norman Görl, Ralf Görlitz, Karl-Heinz Göttl, Beate Göttle, Ricardo Grieshaber Bouyer, Gisela Grothues, Florian Günther, Mirjam Haag, Linda Haas, Anna Haas-Wöhrle, Denitsa Hadjiski, Till Hallmann-Böhm, Peter Härle, Charlotte Hasenkamp, Maura-Maria Hauf, and Matthias Hauser

Subjects
Medicine
Abstract

Objective To analyse the clinical profile of SARS-CoV-2 breakthrough infections in at least double-vaccinated patients with inflammatory rheumatic diseases (IRDs).Methods Data from the physician-reported German COVID-19-IRD registry collected between February 2021 and July 2022 were analysed. SARS-CoV-2 cases were stratified according to patients’ vaccination status as being not vaccinated, double-vaccinated or triple-vaccinated prior to SARS-CoV-2 infection and descriptively compared. Independent associations between demographic and disease features and outcome of breakthrough infections were estimated by multivariable logistic regression.Results In total, 2314 cases were included in the analysis (unvaccinated n=923, double-vaccinated n=551, triple-vaccinated n=803, quadruple-vaccinated n=37). SARS-CoV-2 infections occurred after a median of 151 (range 14–347) days in patients being double-vaccinated, and after 88 (range 14–270) days in those with a third vaccination. Hospitalisation was required in 15% of unvaccinated, 8% of double-vaccinated and 3% of triple-vaccinated/quadruple-vaccinated patients (p

Published
2023
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2. Etanercept is effective as monotherapy or in combination with methotrexate in rheumatoid arthritis: subanalysis of an observational study

Author

T. Meng, O. Behmer, R. Lippe, Markus Gaubitz, Peter-Andreas Löschmann, and Karl-Heinz Göttl

Subjects
musculoskeletal diseases, Adult, Male, medicine.medical_specialty, Pharmacology, Gastroenterology, Severity of Illness Index, Receptors, Tumor Necrosis Factor, Etanercept, Arthritis, Rheumatoid, 03 medical and health sciences, 0302 clinical medicine, Rheumatology, Internal medicine, Germany, medicine, Clinical endpoint, Humans, 030212 general & internal medicine, Functional ability, Prospective Studies, skin and connective tissue diseases, Adverse effect, Aged, 030203 arthritis & rheumatology, business.industry, Remission Induction, General Medicine, Middle Aged, medicine.disease, Confidence interval, Methotrexate, Treatment Outcome, Rheumatoid arthritis, Antirheumatic Agents, Drug Therapy, Combination, Female, business, medicine.drug
Abstract

Approximately 30% of patients with rheumatoid arthritis receiving biological disease-modifying antirheumatic drugs (bDMARDs) take them as monotherapy. Although etanercept (ETN) monotherapy has been evaluated in clinical trials, data in the real-world setting are sparse. We compared the efficacy and safety of ETN, given alone or in combination with methotrexate (MTX), in routine clinical practice. This was a subanalysis of patients who received either ETN alone or ETN + MTX during a 52-week prospective, observational study conducted at 329 German centers. The primary endpoint was “Funktionsfragebogen Hannover” (Hannover Functional Ability Questionnaire [FFbH]; low FFbH = worse function) functional remission at week 26 and week 52. Secondary endpoints included the 28-joint count Disease Activity Score (DAS28), DAS28 remission (DAS28

Published
2017

3. Interaural attenuation in the cat, measured with single fibre data

Author

Karl-Heinz Göttl, David Caird, and Rainer Klinke

Subjects
Physics, medicine.medical_specialty, Cochlear microphonic, Attenuation, Systematic variation, Strychnine, Audiology, Vestibulocochlear Nerve, Single fibre, Sensory Systems, Crosstalk (biology), Bone conduction, Nuclear magnetic resonance, Nerve Fibers, Neurons, Efferent, Acoustic Stimulation, otorhinolaryngologic diseases, medicine, Cats, Cochlear Microphonic Potentials, Animals, Psychoacoustics, Cochlear microphonic potential, Bone Conduction
Abstract

Acoustic crosstalk was measured in the pentobarbital anesthetized cat using the responses of single units in the auditory nerve to ipsilateral and contralateral sound stimuli. The mean interaural attenuation (IATT) was found to be 76 dB between 350 and 18,000 Hz. No systematic variation of IATT with frequency was found although a large variation between different units with similar characteristic frequencies could be seen. We suggest that this scatter is due to the complex fine structure of the bone conduction pathways (Tonndorf (1966) Bone conduction. Acta Otolaryngol. Suppl. 213, 1-132). There are large discrepancies between these data and values obtained using cochlear microphonic potentials as an indicator. We suggest that cochlear microphonic crosstalk data in the literature should be treated with caution as it is extremely difficult to exclude the effect or direct electrical crosstalk on these analog signals.

Published
1980

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