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1. Der Einfluß des pflanzlichen Sekretolytikums Gelomyrtol® forte auf die mukoziliäre Clearance der Kieferhöhle*

Author

H. Behrbohm, Karin Sydow, and O. Kaschke

Subjects
Drug, medicine.medical_specialty, Meatus, Maxillary sinus, Mucociliary clearance, business.industry, media_common.quotation_subject, Sinus surgery, Surgery, medicine.anatomical_structure, Otorhinolaryngology, Anesthesia, otorhinolaryngologic diseases, medicine, business, Gelomyrtol, Sinus (anatomy), Nose, media_common
Abstract

Background To date, there has not been sufficient experimental evidence to demonstrate the pharmacological effect of secretolytic and mucolytic drugs. Methods Scintigraphic studies to detect the mucociliary clearance in the maxillary sinus before and after application of the secretolytic drug Gelomyrtol forte were performed on four healthy persons and one patient after sinus surgery. The most important parameter was the mucociliary transport velocity of the "region of interest-maxillary sinus" and the increase of radioactivity accumulated in a tampon placed in the middle meatus of the nose. Measurements were done with a gamma-camera, 99 m Technetium-sulphurcolloid was used as the radiopharmacentical. A dose of 1 MBq in 0.2 ml NaCl-solution was injected into the maxillary sinus. Results The results show a clear increase of mucociliary transport velocity in the maxillary sinus after intake of secretolytics in connection with an increase of radioactivity in the tampon. Discussion The results can be explained by the secretolytic and secretomotoric effects of the investigated drug. Conclusion The study reveals that ethereal oils have secretolytic effects and also have a pharmacological effect on the mucociliary apparatus.

Published
1995
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2. Practical Approach for Determining Glomerular Filtration Rate by Single-Injection Inulin Clearance

Author

Klaus Jung, Bernd-Detlef Schulze, S Klotzek, K. Precht, Wolfgang Henke, and Karin Sydow

Subjects
Inulin Clearance, Kidney, Chromatography, urogenital system, Biochemistry (medical), Clinical Biochemistry, Inulin, Renal function, Single injection, chemistry.chemical_compound, medicine.anatomical_structure, Bolus (medicine), chemistry, medicine, Volume concentration, Bolus injection
Abstract

We compared the glomerular filtration rate as measured by a single-injection inulin clearance with that measured by a standard isotope method with 99mTc-labeled diethylenetriaminopentaacetic acid in 21 subjects with glomerular filtration rates greater than 35 mL/min. After a bolus injection of 5 g of inulin, blood samples were taken 20, 45, 90, 120, 145, 180, and 240 min afterwards. Inulin was measured by optimized chemical or enzymatic methods of high analytical sensitivity to determine inulin at low concentrations. We used the one-compartment model and inulin concentrations measured at two sampling times to calculate the glomerular filtration rate from the data of the disappearance curve of inulin. Inulin concentrations at 20 and 240 min after injection of the inulin bolus were suited to estimate glomerular filtration rate by this procedure, resulting in values (y) comparable with those obtained by isotope technique (x). The relationship to the isotope technique was characterized by the equation y = +4.80 mL/min + 0.92x (r = 0.97). The single-injection inulin clearance determination can detect a decrease of glomerular filtration rate at the beginning of kidney damage, given that our study included subjects with glomerular filtration rates greater than 35 mL/min. We conclude that the glomerular filtration rate can be determined by analyzing only two blood samples after a bolus injection of inulin.

Published
1992
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3. Contents, Vol. 59, 1991

Author

Hajime Nakamura, Patrick Netter, Motoyuki Minato, Naoki Fujitsuka, Chris Frampton, Ryoko Ozaki, S. Delprato, P.G. McNally, Richard Sainsbury, Tamar Shkolnik, Joon H. Hong, G. Rostoker, K. Jochmans, Florencio Garcia-Martín, Fernando Saiz, Batia Kristal, A. Davenport, P. Fardellone, Susan R. Nicoll, Nikolaos Sofikitis, J. L. Sebert, Patrick Fener, Vera Delaney, Yasuhiko Tomino, Christina Kanaka, Charles van Ypersele de Strihou, J. R. Elliot, Ornanong Bejraputra, Oskar H. Oetliker, Serge Quérin, C. Jacobs, Karin Sydow, J. Bonal, H. Terzidis, A. Vigil, Hatem Smaoui, Eduardo Martín-Escobar, N. El Esper, Osnat Steinberger, Shyi-Jang Shin, Sacristán Del Castillo, Brigitte Schiller, Takahiko Kawagishi, J. Bonet, Lea-Yea Chuang, Ioannis Alexopoulos, S. Saivin, J. Feehally, Shunichi Shiozawa, Horacio Ajzen, Sumine Onaga, T. Horsburgh, Yumio Kikkawa, F. Roca, R. Molina, Ana Gonzalo, Norishige Yoshikawa, J. van der Meulen, D. Verbeelen, Teruo Kitagawa, Alain Gaucher, George E. Digenis, Louise Charron, Klaus Precht, Prathip Phantumvanit, H.W.L. Ziegler-Heitbwck, L. Guerra, A. Caralps, Kaoru Yoshinaga, Audrey King, Kazuyoshi Okada, Soto Alvarez, Jose Tiburcio M. Neto, Yutaka Kobayashi, D.D. Tran, David Nusam, Dhevy Watana, B. Boneu, Josef Kovarik, B.J. Nankivell, Mitsumine Fukui, J.M. Dubert, Kunihiro Doi, Borràs Sans, Kazunari Iidaka, Keishi Abe, Yuji Nagura, Khalid M.H. Butt, Yasuhisa Okuno, Toshio Kameie, Michiyo Saitoh, Kyoko Ohno, Hidekazu Shigematsu, E.J. Will, Koji Ono, Nigel Wardle, N. Kaminsky, Juei-Hsiung Tsai, Pierre Wallemacq, Lg. Thijs, E. Raz, Miriam Barzilai, Carlos Quereda, A.M. Davison, R. Rodriguez, Fernando Moldenhauer, Peter Pietschmann, Yoshiyuki Hiki, R.V. Heatley, Ross R. Bailey, J. Muñoz-Gomez, Alkis Kostakis, Bärbel Schmidt, Michinobu Hatano, Francisco Mampaso, Madeleine Cheignon, Nicholas Zeferos, Hikaru Koide, J. Walls, M. Llanos, B. Weil, C. Goudable, H. Deramond, Aiju Kameda, T.M. Shallcross, Yoshiki Nishizawa, Wolfgang Henke, G. Deray, Tsutomu Koumi, Vitoon Prasongwattana, A. Fournier, Caroline Borot, Nobuyuki Watanabe, Nabil Sumrani, Mary Christophoraki, Masatoshi Wakui, Jinn-Yuh Guh, José Pedraza-Chaverri, J.M. Suc, Misao Owada, Takao Saruta, Daniel Burnel, P. Lang, Kyoji Kondo, H. Tonthat, Silke Klotzek, Alain Bonnardeaux, G. Lagrue, G. Brillet, Makumkrong Poshyachinda, Wolfgang Woloszczuk, Prasit Futrakul, J. Arnal, Mitsuharu Narita, Piyarat Tosukhowong, Takako Yokozawa, J. G. Turner, J.J.P. Nauta, Yoshihiko Ueda, Joaquín Ortuño, E. Mirapeix, A. Baumelou, Akihiw Iino, Nicolette Meyer, Akihiro Toyokawa, Lea Labin, A. Marie, Ikuo Miyagawa, Gabriel de Arriba, Li Ning Wang, Hikokichi Oura, Zenshiro Inage, Susumu Takahashi, P. Van der Niepen, J.E. Crabtree, Alberto Huberman, J. Sennesael, Mario G. Bianchetti, Pote Sriboonlue, Yutaka Yaguchi, Chawalit Preeyasombati, M. Brezis, Klaus Jung, P. Sie, Rajanee Sensirivatana, Takako Matsuzaki, Akira Osawa, Hirotoshi Morii, P. Gallar, A. Remond, L.O. Simpson, Toru Hyodo, M. Petit-Phar, Jean-Pierre Mallie, Jean Schaeverbeke, Michèle Kessler, Marcos Bosi Ferraz, A.G. Herman, E. Hernández, Aparecido B. Pereira, Visith Sitprija, G. Houin, Helen Gyftaki, Jm. Campistol, Julio Pascual, Frank Martinez, Kazuo Tsunoda, Ricardo Sesso, Ana Pardo, Hajime Inamoto, Spyros Moulopoulos, A.B.J. Groeneveld, Masaki Kobayashi, Alsar Ortiz, Bernd-Detlef Schulze, L. Revert, Tetsuo Shoji, Shaul M. Shasha, Kriang Tungsanga, Ph. Morinière, M. De Waele, Matthias Blumenstein, Andreas Vychytil, Yung-Hsiung Lai, Yves Pirson, A. Oliet, Ehud U. Makov, and Akio Koyama

Subjects
Traditional medicine, business.industry, Medicine, business
Published
1991
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4. Subject Index, Vol. 59, 1991

Author

A. Davenport, P. Fardellone, Richard Sainsbury, L. Revert, Yves Pirson, Carlos Quereda, Ryoko Ozaki, A. Oliet, Charles van Ypersele de Strihou, D.D. Tran, A.G. Herman, Francisco Mampaso, G. Brillet, Shyi-Jang Shin, Yuji Nagura, Alberto Huberman, J. Sennesael, Ikuo Miyagawa, J. Muñoz-Gomez, Shaul M. Shasha, Takao Saruta, Hikaru Koide, Mario G. Bianchetti, J. R. Elliot, N. El Esper, Koji Ono, Julio Pascual, Sacristán Del Castillo, Patrick Netter, Motoyuki Minato, Pote Sriboonlue, Spyros Moulopoulos, A.B.J. Groeneveld, E. Hernández, Aparecido B. Pereira, Yutaka Yaguchi, J. Walls, George E. Digenis, Ana Pardo, Chawalit Preeyasombati, B. Weil, H. Tonthat, Hajime Inamoto, Frank Martinez, Peter Pietschmann, R. Molina, Masaki Kobayashi, Alsar Ortiz, C. Goudable, Patrick Fener, A. Fournier, Ehud U. Makov, J.M. Suc, Ricardo Sesso, J. Bonal, S. Delprato, Kazuo Tsunoda, P.G. McNally, Yoshiki Nishizawa, Borràs Sans, E. Raz, Tamar Shkolnik, Mitsuharu Narita, T.M. Shallcross, J. Bonet, J. Feehally, Alain Gaucher, R. Rodriguez, Ph. Morinière, Visith Sitprija, G. Houin, Fernando Moldenhauer, Jose Tiburcio M. Neto, Helen Gyftaki, Christina Kanaka, K. Jochmans, P. Lang, Fernando Saiz, Michiyo Saitoh, Akio Koyama, L.O. Simpson, Lg. Thijs, G. Rostoker, Joon H. Hong, Florencio Garcia-Martín, Ana Gonzalo, Norishige Yoshikawa, Matthias Blumenstein, Miriam Barzilai, R.V. Heatley, Horacio Ajzen, Ornanong Bejraputra, A. Baumelou, Pierre Wallemacq, Vera Delaney, Yasuhiko Tomino, A. Remond, Soto Alvarez, Yoshiyuki Hiki, Nicolette Meyer, Lea Labin, Serge Quérin, C. Jacobs, Susan R. Nicoll, Mary Christophoraki, Masatoshi Wakui, Yutaka Kobayashi, Dhevy Watana, Silke Klotzek, Andreas Vychytil, Josef Kovarik, Li Ning Wang, Bärbel Schmidt, Michinobu Hatano, Jean Schaeverbeke, Hikokichi Oura, G. Lagrue, J. L. Sebert, J.M. Dubert, Ioannis Alexopoulos, Eduardo Martín-Escobar, Toshio Kameie, Hatem Smaoui, Osnat Steinberger, Misao Owada, Kyoko Ohno, M. Llanos, Aiju Kameda, M. De Waele, Hidekazu Shigematsu, Juei-Hsiung Tsai, S. Saivin, Makumkrong Poshyachinda, Wolfgang Henke, H. Terzidis, Vitoon Prasongwattana, G. Deray, Tsutomu Koumi, Sumine Onaga, Daniel Burnel, Wolfgang Woloszczuk, F. Roca, Michèle Kessler, Rajanee Sensirivatana, Ross R. Bailey, Klaus Precht, N. Kaminsky, Prathip Phantumvanit, Jinn-Yuh Guh, Lea-Yea Chuang, Batia Kristal, Alkis Kostakis, Kyoji Kondo, Akihiro Toyokawa, Nikolaos Sofikitis, Hirotoshi Morii, P. Gallar, Takako Matsuzaki, J. van der Meulen, D. Verbeelen, L. Guerra, Hajime Nakamura, Naoki Fujitsuka, Oskar H. Oetliker, M. Petit-Phar, Jean-Pierre Mallie, Teruo Kitagawa, Chris Frampton, Kaoru Yoshinaga, H. Deramond, J.J.P. Nauta, David Nusam, H.W.L. Ziegler-Heitbwck, Karin Sydow, Brigitte Schiller, B. Boneu, A. Vigil, Caroline Borot, Bernd-Detlef Schulze, Takahiko Kawagishi, Yung-Hsiung Lai, A. Caralps, B.J. Nankivell, Kunihiro Doi, T. Horsburgh, Yumio Kikkawa, Joaquín Ortuño, Louise Charron, Yasuhisa Okuno, Kazunari Iidaka, Tetsuo Shoji, Shunichi Shiozawa, Akira Osawa, Audrey King, Kazuyoshi Okada, Keishi Abe, E. Mirapeix, Khalid M.H. Butt, A. Marie, Zenshiro Inage, E.J. Will, Kriang Tungsanga, J.E. Crabtree, M. Brezis, Mitsumine Fukui, Klaus Jung, P. Sie, Nigel Wardle, Nabil Sumrani, Nobuyuki Watanabe, Piyarat Tosukhowong, Takako Yokozawa, J. G. Turner, Yoshihiko Ueda, José Pedraza-Chaverri, Toru Hyodo, Marcos Bosi Ferraz, Jm. Campistol, Akihiw Iino, Alain Bonnardeaux, Prasit Futrakul, J. Arnal, Gabriel de Arriba, Susumu Takahashi, P. Van der Niepen, A.M. Davison, Madeleine Cheignon, and Nicholas Zeferos

Subjects
Index (economics), business.industry, Statistics, Medicine, Subject (documents), business
Published
1991
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5. Single-Injection Inulin Clearance Using Only One Blood Sample as a Suitable Procedure to Measure Glomerular Filtration Rate

Author

Bernd-Detlef Schulze, Wolfgang Henke, Silke Klotzek, Klaus Precht, Karin Sydow, and Klaus Jung

Subjects
Adult, Male, Inulin Clearance, Chromatography, Metabolic Clearance Rate, business.industry, Sample (material), Inulin, Measure (physics), Renal function, Single injection, Filtration fraction, Injections, Intravenous, Humans, Medicine, Female, Kidney Diseases, business, Glomerular Filtration Rate, Clearance
Published
1991
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6. Diagnostic Value of Low-Molecular Mass Proteins in Serum for the Detection of Reduced Glomerular Filtration Rate

Author

Karin Sydow, Klaus Jung, Klaus Precht, Jb.-D. Schulze, Monika Pergande, and Gottfried Schreiber

Subjects
Adult, Male, medicine.medical_specialty, education, Clinical Biochemistry, Renal function, chemistry.chemical_compound, Ribonucleases, Internal medicine, medicine, Humans, Ribonuclease, Normal range, Creatinine, Molecular mass, biology, Beta-2 microglobulin, Biochemistry (medical), Blood Proteins, General Medicine, Confidence interval, Endocrinology, chemistry, biology.protein, Female, Kidney Diseases, Muramidase, Lysozyme, beta 2-Microglobulin, Glomerular Filtration Rate
Abstract

Summary: The diagnostic value of the low-molecular mass proteins ribonuclease, s2-microglobulin, and lysozyme in serum for the detection of reduced glomerular filtration rates was evaluated. The values of these proteins and of serum creatinine investigated in 52 patients suffering from chronic renal diseases were plotted against "m-Tc^diethylenetrianiinopentaacetate clearance as an indicator of glomerular filtration rate. Log- transformed data showed a gpod fit pf linearity. Considering the 95% confidence limits of the regression equations, ribonuclease increased above the normal range when the glomerular filtration rate was lower than 1.24 ml/s whereas the other analytes partly remained within their normal limits. Out of those 18 patients with glomerular filtration rates lower than 1.24 ml/s, all patients showed elevated ribonuclease levels. s2- Microglobulin, creatinine, and lysozyme were increased in 17, 14, and 12 cases, respectively. Ribonuclease and s2-microglobulin showed similar results when other diagnostic criteria (specificity, efficiency and predic- tive values) were taken into account. We recommend ribonuclease determination in serum for the detection of reduced glomerular filtration rate in the normal range of creatinine. The test is diagnostically powerful, cheap and easy to perform.

Published
1987
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7. Results of a double blind study of 89-strontium therapy of skeletal metastases of prostatic carcinoma

Author

Dietmar Schnorr, Karin Sydow, Klaus Buchali, Correns Hj, Michael Schuerer, and Hildegard Lips

Subjects
Male, medicine.medical_specialty, medicine.medical_treatment, Urology, Bone Neoplasms, Placebo, Metastasis, Random Allocation, Double-Blind Method, Prostate, Carcinoma, medicine, Humans, Radiology, Nuclear Medicine and imaging, Survival rate, Aged, Clinical Trials as Topic, Epithelioma, business.industry, Palliative Care, Prostatic Neoplasms, General Medicine, Middle Aged, Prognosis, medicine.disease, Surgery, Radiation therapy, medicine.anatomical_structure, Radionuclide therapy, Strontium Radioisotopes, business
Abstract

Forty-nine patients were treated with either 3 x 75 MBq 89Sr or saline as placebo. Analysis of results 1 to 3 years after therapy revealed the ineffectiveness of 89Sr to relieve pain from metastases. Unexpectedly, a higher survival rate was found after Sr application (46% vs 4% after 2 years). Covariate analysis underlines the effect of 89Sr therapy on life expectation.

Published
1988
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8. Diagnostic significance of different urinary enzymes in patients suffering from chronic renal diseases

Author

Karin Sydow, Klaus Jung, and Bernd-Detlef Schulze

Subjects
Nephrology, medicine.medical_specialty, Urinary system, Clinical Biochemistry, Renal function, CD13 Antigens, Biochemistry, Aminopeptidases, Nephropathy, chemistry.chemical_compound, Glomerulonephritis, Ribonucleases, Reference Values, Internal medicine, Acetylglucosaminidase, medicine, Humans, Glucosaminidase, Creatinine, Pyelonephritis, Biochemistry (medical), General Medicine, gamma-Glutamyltransferase, medicine.disease, Alkaline Phosphatase, Endocrinology, Hexosaminidases, chemistry, Chronic Disease, Alanine aminopeptidase, Kidney disease
Abstract

The urinary enzymes alanine aminopeptidase (EC 3.4.11.2), alkaline phosphatase (EC 3.1.3.1), γ-glutamyltransferase (EC 2.3.2.2), N- acetyl -β- d - glucosaminidase (EC 3.2.1.30), and ribonuclease (EC 3.1.4.22) were measured in 66 healthy persons and 52 patients suffering from chronic renal disease (Pyelonephritis, glomerulonephritis). The residual renal function of patients characterized by 99mTc-diethylenetri-aminopentaacetate isotope clearance was only moderately reduced. Except for γ-glutamyltransferase, patients generally showed increased urinary enzyme excretions. N- Acetyl -β- d - glucosaminidase was more sensitive to detect renal dysfunction than the other enzymes and the conventional parameters serum creatinine, total protein excretion, and the measurement of glomerular filtration rate. The determination of this enzyme can be recommended as a suitable diagnostic parameter in nephrology.

Published
1987

9. On the Efficacy of Strontium-89 Therapy. Preliminary Evaluation of a Double-blind Study

Author

M. Schürer, Dietmar Schnorr, Karin Sydow, Hildegard Lips, Correns Hj, B. Johannsen, and Klaus Buchali

Subjects
Prostatic Gland, Double blind study, Oncology, medicine.medical_specialty, business.industry, Strontium 89 therapy, Internal medicine, Medicine, Bone metastasis, Prostate carcinoma, business, medicine.disease
Abstract

In 1970 and 1982, we reported on the results of Sr-89 treatment of pain caused by bone metastases in 81 patients with prostate carcinoma [1, 2]. Due to uncertainty inherent in the evaluation of this treatment within the manifold therapy of such patients, we decided, in agreement with the therapy commission of our Faculty of Medicine, to start a double-blind investigation in order to differentiate the Sr-89 effect from effects of simultaneously applied drugs (hormones, cytostatics etc.)

Published
1986
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10. Quantification of the negative feedback mechanism between pituitary and thyroid in subjects with normal thyroid function

Author

Dieter Emrich, Olaf Gefeller, Inge Schreivogel, and Karin Sydow

Subjects
Adult, Male, endocrine system, medicine.medical_specialty, endocrine system diseases, Adolescent, Endocrinology, Diabetes and Metabolism, medicine.medical_treatment, Thyroid Gland, Thyrotropin, Thyroglobulin, Feedback, Basal (phylogenetics), Endocrinology, Reference Values, Internal medicine, Negative feedback, medicine, Humans, Triiodothyronine, Dose-Response Relationship, Drug, Chemistry, Thyroid, General Medicine, Free thyroxine, Normal thyroid function, 3. Good health, Thyroxine, medicine.anatomical_structure, Free triiodothyronine, Pituitary Gland, hormones, hormone substitutes, and hormone antagonists
Abstract

Sydow K, Emrich D, Gefeller O, Schreivogel I. Quantification of the negative feedback mechanism between pituitary and thyroid in subjects with normal thyroid function. Eur J Endocrinol 1996;135:316–21. ISSN 0804–4643 Using sufficiently sensitive and precise assays, we systematically investigated the correlation between thyrotropin, thyroglobulin, index of free thyroxine and index of free triiodothyronine after different doses of thyroxine (25, 50, 100, 150 μg), which were administered daily for 10 days to individuals with normal thyroid function and in a control group. Analysis of the data using relative median values expressing changes to basal values before administration of thyroxine yielded the following results: (i) thyrotropin and thyroglobulin decreased monoexponentially, depending on the doses of thyroxine administered; (ii) the extent of their decrease showed a linear correlation with the dose of thyroxine administered and was greater for thyrotropin than for thyroglobulin; (iii) the relative velocity of their decrease increased monoexponentially with the dose of thyroxine and did not differ between thyrotropin and thyroglobulin. These results provide strong evidence for a clear quantitative reaction of the feedback mechanism and confirm that the secretion of thyroglobulin is a physiological process dependent on thyrotropin. The high intra-individual variations obtained for thyrotropin were probably due to its pulsatile secretion. D. Emrich, Department of Nuclear Medicine, University of Göttingen, Robert-Koch-Str. 40, D-37075 Göttingen, Germany

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