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1. Cystic fibrosis related diabetes is not associated with maximal aerobic exercise capacity in cystic fibrosis: a cross-sectional analysis of an international multicenter trial

Author

Eber, Ernst, Wagner, Marlies, Ellemunter, Helmut, Lands, Larry C, Alarie, Nancy, Karila, Chantal, Simon, Clotilde, Faucou, Anne, Mely, Laurent, Ravaninjatovo, Bruno, Prevotat, Anne, Hebestreit, Helge, Schaeff, Jonathan, Stein, Lothar, Koerner-Rettberg, Cordula, Hammermann, Jutta, Smaczny, Christina, Held, Inka, Junge, Sibylle, Nitsche, Oliver, Fischer, Rainald, Große-Onnebrink, Jörg, Wesner, Anne, Hector, Andreas, Hebestreit, Alexandra, Kriemler, Susi, Schindler, Christian, Radtke, Thomas, Benden, Christian, Casaulta, Carmen, Fischer, Reta, Möller, Alexander, Hulzebos, Erik, Burghard, Marcella, Urquhart, Don S, Blacklock, Sarah, Miller, Debbie, Johnstone, Zoe, Orenstein, David M, Lowman, John D, and Haile, Sarah R

Published
2023
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3. Cystic fibrosis related diabetes is not associated with maximal aerobic exercise capacity in cystic fibrosis: a cross-sectional analysis of an international multicenter trial

Author

Radtke, Thomas, primary, Kriemler, Susi, additional, Stein, Lothar, additional, Karila, Chantal, additional, Urquhart, Don S, additional, Orenstein, David M, additional, Lands, Larry C, additional, Schindler, Christian, additional, Eber, Ernst, additional, Haile, Sarah R, additional, Hebestreit, Helge, additional, Eber, Ernst , additional, Wagner, Marlies, additional, Ellemunter, Helmut, additional, Alarie, Nancy, additional, Simon, Clotilde, additional, Faucou, Anne, additional, Mely, Laurent, additional, Ravaninjatovo, Bruno, additional, Prevotat, Anne, additional, Hebestreit, Helge , additional, Schaeff, Jonathan, additional, Koerner-Rettberg, Cordula, additional, Hammermann, Jutta, additional, Smaczny, Christina, additional, Held, Inka, additional, Junge, Sibylle, additional, Nitsche, Oliver, additional, Fischer, Rainald, additional, Große-Onnebrink, Jörg, additional, Wesner, Anne, additional, Hector, Andreas, additional, Hebestreit, Alexandra, additional, Radtke, Thomas , additional, Benden, Christian, additional, Casaulta, Carmen, additional, Fischer, Reta, additional, Möller, Alexander, additional, Hulzebos, Erik, additional, Burghard, Marcella, additional, Urquhart, Don S , additional, Blacklock, Sarah, additional, Miller, Debbie, additional, Johnstone, Zoe, additional, and Lowman, John D, additional

Published
2023
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4. CFTR Genotype and Maximal Exercise Capacity in Cystic Fibrosis. A Cross-Sectional Study

Author

Radtke, Thomas, Hebestreit, Helge, Gallati, Sabina, Schneiderman, Jane E., Braun, Julia, Stevens, Daniel, Hulzebos, Erik H. J., Takken, Tim, Boas, Steven R., Urquhart, Don S., Lands, Larry C., Tejero, Sergio, Sovtic, Aleksandar, Dwyer, Tiffany, Petrovic, Milos, Harris, Ryan A., Karila, Chantal, Savi, Daniela, Usemann, Jakob, Mei-Zahav, Meir, Hatziagorou, Elpis, Ratjen, Felix, and Kriemler, Susi

Published
2018
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6. Effects of a Partially Supervised Conditioning Program in Cystic Fibrosis: An International Multicenter, Randomized Controlled Trial (ACTIVATE-CF)

Author

Hebestreit, Helge, primary, Kriemler, Susi, additional, Schindler, Christian, additional, Stein, Lothar, additional, Karila, Chantal, additional, Urquhart, Don S., additional, Orenstein, David M., additional, Lands, Larry C., additional, Schaeff, Jonathan, additional, Eber, Ernst, additional, Radtke, Thomas, additional, Wagner, Marlies, additional, Ellemunter, Helmut, additional, Alarie, Nancy, additional, Simon, Clotilde, additional, Faucou, Anne, additional, Mely, Laurent, additional, Ravaninjatovo, Bruno, additional, Prevotat, Anne, additional, Koerner-Rettberg, Cordula, additional, Hammermann, Jutta, additional, Smaczny, Christina, additional, Held, Inka, additional, Junge, Sibylle, additional, Nitsche, Oliver, additional, Fischer, Rainald, additional, Große-Onnebrink, Jörg, additional, Wesner, Anne, additional, Hector, Andreas, additional, Hebestreit, Alexandra, additional, Benden, Christian, additional, Casaulta, Carmen, additional, Fischer, Reta, additional, Möller, Alexander, additional, Hulzebos, Erik, additional, Burghard, Marcella, additional, Blacklock, Sarah, additional, Miller, Debbie, additional, Johnstone, Zoe, additional, and Lowman, John D., additional

Published
2022
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9. Rapid Improvement after Starting Elexacaftor–Tezacaftor–Ivacaftor in Patients with Cystic Fibrosis and Advanced Pulmonary Disease

Author

Burgel, Pierre-Régis, primary, Durieu, Isabelle, additional, Chiron, Raphaël, additional, Ramel, Sophie, additional, Danner-Boucher, Isabelle, additional, Prevotat, Anne, additional, Grenet, Dominique, additional, Marguet, Christophe, additional, Reynaud-Gaubert, Martine, additional, Macey, Julie, additional, Mely, Laurent, additional, Fanton, Annlyse, additional, Quetant, Sébastien, additional, Lemonnier, Lydie, additional, Paillasseur, Jean-Louis, additional, Da Silva, Jennifer, additional, Martin, Clémence, additional, Andrejak, Claire, additional, Becourt, Arnaud, additional, Mounard, Julie, additional, Poulet, Claire, additional, Rames, Cinthia, additional, Talleux, Marie, additional, Chevalier, Marie-Chantal, additional, Darviot, Estelle, additional, Jouvenot, Marie, additional, Marien, Caroline, additional, Paris, Audrey, additional, Pelatan, Cécile, additional, Person, Christine, additional, Priou, Pascaline, additional, Troussier, Françoise, additional, Urban, Thierry, additional, Dalphin, Marie-Laure, additional, Dalphin, Jean-Charles, additional, Ladaurade, Alice, additional, Pernet, Didier, additional, Richaud-Thiriez, Bénédicte, additional, Roux-Claude, Pauline, additional, Blanc, Nathalia, additional, Boisserie-Lacroix, Vincent, additional, Bui, Stephanie, additional, Collet, Cyrielle, additional, Debelleix, Stéphane, additional, Bergot, Emmanuel, additional, Brouard, Jacques, additional, Campbell, Karine, additional, Laurans, Muriel, additional, Ribault, Virginie, additional, Borderon, Corinne, additional, Heraud, Marie-Christine, additional, Labbe, Guillaume, additional, Montcouquiol, Sylvie, additional, Petit, Isabelle, additional, Ruivard, Marc, additional, Delestrain, Céline, additional, Douvry, Benoit, additional, Epaud, Ralph, additional, Maitre, Bernard, additional, Remus, Natascha, additional, Beltramo, Guillaume, additional, Houzel, Anne, additional, Huet, Frédéric, additional, Perez, Stéphanie, additional, Boldron-Ghaddar, Amale, additional, Scalbert, Manuela, additional, Bouzioukh, Rabah, additional, Simon, Charles, additional, Camara, Boubou, additional, Hamidfar, Rébecca, additional, Llerena, Catherine, additional, Pin, Isabelle, additional, Deschildre, Antoine, additional, Gicquello, Alice, additional, Le Rouzic, Olivier, additional, Leroy, Clara, additional, Paris, Nicolas, additional, Perez, Thierry, additional, Thumerelle, Caroline, additional, Turck, Dominique, additional, Wizla, Nathalie, additional, Dupuy-Grasset, Magali, additional, Languepin, Jane, additional, Masson-Rouchaud, Alexandra, additional, Menetrey, Céline, additional, Durupt, Stéphane, additional, L’Excellent, Sophie, additional, Nove-Josserand, Raphaele, additional, Ohlmann, Camille, additional, Reix, Phillipe, additional, Reynaud, Quitterie, additional, Werck-Gallois, Marie-Christine, additional, Baravalle, Mélissandre, additional, Coltey, Bérangère, additional, Desmazes-Dufeu, Nadine, additional, Dubus, Jean-Christophe, additional, Gautier, Clarisse, additional, Rey, Jean-Baptiste, additional, Stremler, Nathalie, additional, Caimmi, Davide, additional, Devrait, Margot, additional, Moreau, Johan, additional, Billon, Yves, additional, Blondé, Aurore, additional, Guillaumot, Anne, additional, Kiefer, Sébastien, additional, Peretti, Laura, additional, Tatopoulos, Aurélie, additional, Tiotiu, Angélica, additional, Benhamida, Myriam, additional, Bihouee, Tiphaine, additional, Eschapasse, Emmanuel, additional, Tissot, Adrien, additional, Giannantonio, Marie, additional, Leroy, Sylvie, additional, Piccini-Bailly, Carole, additional, Pradelli, Johana, additional, Messika, Jonathan, additional, Boussaud, Véronique, additional, Burgel, Pierre-Régis, additional, Carlier, Nicolas, additional, Honoré, Isabelle, additional, Hubert, Dominique, additional, Kanaan, Reem, additional, Bailly-Botuha, Céline, additional, Chedevergne, Frédérique, additional, De Blic, Jacques, additional, Delacourt, Christophe, additional, Drummond, David, additional, Fauroux, Brigitte, additional, Karila, Chantal, additional, Le Bourgeois, Muriel, additional, Sermet, Isabelle, additional, Delaisi, Bertrand, additional, Gerardin, Michèle, additional, Houdouin, Veronique, additional, Leclainche, Laurence, additional, Aubertin, Guillaume, additional, Berdah, Laura, additional, Clement, Annick, additional, Corvol, Harriet, additional, Nathan, Nadia, additional, Prevost, Blandine, additional, Richard, Nicolas, additional, Tamalet, Aline, additional, Taytard, Jessica, additional, Thouvenin, Guillaume, additional, Tourniaire, Barbara, additional, Abely, Michel, additional, Bessaci-Kabouya, Katia, additional, Dury, Sandra, additional, Ravoninjatovo, Bruno, additional, Dabadie, Alain, additional, Dagorne, Michel, additional, Deneuville, Eric, additional, Jamin, Marie, additional, Ribault, Mélanie, additional, Vigier, Clémentine, additional, Belleguic, Chantal, additional, Brinchault, Graziella, additional, Desrues, Benoit, additional, Barzic, Audrey, additional, Dirou-Prigent, Anne, additional, Le Bihan, Jean, additional, Revert, Krista, additional, Ropars, Thomas, additional, Couderc, Laure, additional, Dominique, Stéphane, additional, Morisse-Pradier, Hélène, additional, Pramil, Stéphanie, additional, Thiberville, Luc, additional, Allou, Nathalie, additional, Enaud, Laurent, additional, Gachelin, Elsa, additional, Huchot, Eric, additional, Payet, Annabelle, additional, Perisson, Caroline, additional, Piyaraly, Saguiraly, additional, Valois, Sophie, additional, Herzog, Audrey, additional, Kessler, Romain, additional, Porzio, Michele, additional, Weiss, Laurence, additional, Beaumont, Laurence, additional, Brugiere, Olivier, additional, Colin, Sylvie, additional, Verdiere, de, additional, Cuquemelle, Elise, additional, De Miranda, Sandra, additional, Monem Hamid, Adbdul, additional, Parquin, François, additional, Picard, Clément, additional, Roux, Antoine, additional, Roy, Charlotte, additional, Bremont, François, additional, Didier, Alain, additional, Dupuis, Marion, additional, Faviez, Guillaume, additional, Labouret, Géraldine, additional, Mittaine, Marie, additional, Murris-Espin, Marlène, additional, Roditis, Léa, additional, Cosson, Laure, additional, Diot, Patrice, additional, Flament, Thomas, additional, Giraut, Charlotte, additional, Mankikian, Julie, additional, Arnouat, Baptiste, additional, Mousset, Gaétane, additional, Storni, Véronique, additional, Vigneron, Philippe, additional, Coirier-Duet, Emmanuelle, additional, and Gabsi, Asma, additional

Published
2021
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15. Cardiopulmonary exercise testing provides additional prognostic information in cystic fibrosis

Author

Hebestreit, Helge, Hulzebos, Erik H.J., Schneiderman, Jane E., Karila, Chantal, Boas, Steven R., Kriemler, Susi, Dwyer, Tiffany, Sahlberg, Margareta, Urquhart, Don S., Lands, Larry C., Ratjen, Felix, Takken, Tim, Varanistkaya, Liobou, Rücker, Viktoria, Hebestreit, Alexandra, Usemann, Jakob, Radtke, Thomas, Hebestreit, Helge, Hulzebos, Erik H.J., Schneiderman, Jane E., Karila, Chantal, Boas, Steven R., Kriemler, Susi, Dwyer, Tiffany, Sahlberg, Margareta, Urquhart, Don S., Lands, Larry C., Ratjen, Felix, Takken, Tim, Varanistkaya, Liobou, Rücker, Viktoria, Hebestreit, Alexandra, Usemann, Jakob, and Radtke, Thomas

Published
2019

16. Cardiopulmonary exercise testing provides additional prognostic information in cystic fibrosis

Author

Activity&Health sectie exercise, Child Health, Hebestreit, Helge, Hulzebos, Erik H.J., Schneiderman, Jane E., Karila, Chantal, Boas, Steven R., Kriemler, Susi, Dwyer, Tiffany, Sahlberg, Margareta, Urquhart, Don S., Lands, Larry C., Ratjen, Felix, Takken, Tim, Varanistkaya, Liobou, Rücker, Viktoria, Hebestreit, Alexandra, Usemann, Jakob, Radtke, Thomas, Activity&Health sectie exercise, Child Health, Hebestreit, Helge, Hulzebos, Erik H.J., Schneiderman, Jane E., Karila, Chantal, Boas, Steven R., Kriemler, Susi, Dwyer, Tiffany, Sahlberg, Margareta, Urquhart, Don S., Lands, Larry C., Ratjen, Felix, Takken, Tim, Varanistkaya, Liobou, Rücker, Viktoria, Hebestreit, Alexandra, Usemann, Jakob, and Radtke, Thomas

Published
2019

18. Cardiopulmonary Exercise Testing Provides Additional Prognostic Information in Cystic Fibrosis

Author

Hebestreit, Helge, primary, Hulzebos, Erik H. J., additional, Schneiderman, Jane E., additional, Karila, Chantal, additional, Boas, Steven R., additional, Kriemler, Susi, additional, Dwyer, Tiffany, additional, Sahlberg, Margareta, additional, Urquhart, Don S., additional, Lands, Larry C., additional, Ratjen, Felix, additional, Takken, Tim, additional, Varanistkaya, Liobou, additional, Rücker, Viktoria, additional, Hebestreit, Alexandra, additional, Usemann, Jakob, additional, Radtke, Thomas, additional, Junge, Sibylle, additional, Smaczny, Christine, additional, Rand, Sarah, additional, and Dawson, Charlotte, additional

Published
2019
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20. Effects of a partially supervised conditioning programme in cystic fibrosis : An international multi-centre randomised controlled trial (ACTIVATE-CF): Study protocol

Author

Hebestreit, Helge, Lands, Larry C., Alarie, Nancy, Schaeff, Jonathan, Karila, Chantal, Orenstein, David M., Urquhart, Don S., Hulzebos, Erik H.J., Stein, Lothar, Schindler, Christian, Kriemler, Susi, Radtke, Thomas, and the ACTIVATE-CF Study Working Group, Hebestreit, Helge, Lands, Larry C., Alarie, Nancy, Schaeff, Jonathan, Karila, Chantal, Orenstein, David M., Urquhart, Don S., Hulzebos, Erik H.J., Stein, Lothar, Schindler, Christian, Kriemler, Susi, Radtke, Thomas, and and the ACTIVATE-CF Study Working Group

Published
2018

21. Effects of a partially supervised conditioning programme in cystic fibrosis: An international multi-centre randomised controlled trial (ACTIVATE-CF): Study protocol

Author

Kinderbewegingszorg patientenzorg, Child Health, Hebestreit, Helge, Lands, Larry C., Alarie, Nancy, Schaeff, Jonathan, Karila, Chantal, Orenstein, David M., Urquhart, Don S., Hulzebos, Erik H.J., Stein, Lothar, Schindler, Christian, Kriemler, Susi, Radtke, Thomas, and the ACTIVATE-CF Study Working Group, Kinderbewegingszorg patientenzorg, Child Health, Hebestreit, Helge, Lands, Larry C., Alarie, Nancy, Schaeff, Jonathan, Karila, Chantal, Orenstein, David M., Urquhart, Don S., Hulzebos, Erik H.J., Stein, Lothar, Schindler, Christian, Kriemler, Susi, Radtke, Thomas, and and the ACTIVATE-CF Study Working Group

Published
2018

22. Authors’ Reply

Author

Hebestreit, Helge, Arets, Hubertus G M, Aurora, Paul, Boas, Steve, Cerny, Frank, Hulzebos, Erik H J, Karila, Chantal, Lands, Larry C., Lowman, John D., Swisher, Anne, and Urquhart, Don S.

Subjects
Pulmonary and Respiratory Medicine, Letter, Oxygen Consumption, Cystic Fibrosis, Exercise Test, Humans, Reproducibility of Results, Article
Published
2016

23. Authors' Reply

Author

UMC Utrecht, Longziekten patientenzorg, Child Health, Kinderbewegingszorg patientenzorg, Hebestreit, Helge, Arets, Hubertus G M, Aurora, Paul, Boas, Steve, Cerny, Frank, Hulzebos, Erik H J, Karila, Chantal, Lands, Larry C., Lowman, John D., Swisher, Anne, Urquhart, Don S., UMC Utrecht, Longziekten patientenzorg, Child Health, Kinderbewegingszorg patientenzorg, Hebestreit, Helge, Arets, Hubertus G M, Aurora, Paul, Boas, Steve, Cerny, Frank, Hulzebos, Erik H J, Karila, Chantal, Lands, Larry C., Lowman, John D., Swisher, Anne, and Urquhart, Don S.

Published
2016

24. Statement on Exercise Testing in Cystic Fibrosis

Author

Longziekten patientenzorg, Child Health, Kinderbewegingszorg patientenzorg, Hebestreit, Helge, Arets, Hubertus G M, Aurora, Paul, Boas, Steve, Cerny, Frank, Hulzebos, Erik H J, Karila, Chantal, Lands, Larry C, Lowman, John D, Swisher, Anne, Urquhart, Don S, European Cystic Fibrosis Exercise Working Group, Longziekten patientenzorg, Child Health, Kinderbewegingszorg patientenzorg, Hebestreit, Helge, Arets, Hubertus G M, Aurora, Paul, Boas, Steve, Cerny, Frank, Hulzebos, Erik H J, Karila, Chantal, Lands, Larry C, Lowman, John D, Swisher, Anne, Urquhart, Don S, and European Cystic Fibrosis Exercise Working Group

Published
2015

27. The lung is involved in juvenile dermatomyositis

Author

Pouessel, Guillaume, primary, Deschildre, Antoine, additional, Le Bourgeois, Muriel, additional, Cuisset, Jean-Marie, additional, Catteau, Benoit, additional, Karila, Chantal, additional, Nève, Véronique, additional, Thumerelle, Caroline, additional, Quartier, Pierre, additional, and Tillie-Leblond, Isabelle, additional

Published
2012
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30. Cardiopulmonary Exercise Testing Provides Additional Prognostic Information in Cystic Fibrosis.

Author

Hebestreit, Helge, Hulzebos, Erik Hj, Schneiderman, Jane E, Karila, Chantal, Boas, Steven R, Kriemler, Susi, Dwyer, Tiffany, Sahlberg, Margareta, Urquhart, Don S, Lands, Larry C, Ratjen, Felix, Takken, Tim, Varanistkaya, Liobou, Rücker, Viktoria, Hebestreit, Alexandra, Usemann, Jakob, Radtke, Thomas, Prognostic value of CPET in CF study group, and Hulzebos, Erik H J

Abstract

Rationale: The prognostic value of cardiopulmonary exercise testing (CPET) for survival in cystic fibrosis (CF) in the context of current clinical management, when controlling for other known prognostic factors, is unclear.Objectives: To determine the prognostic value of CPET-derived measures beyond peak oxygen uptake ( V. o2peak) following rigorous adjustment for other predictors.Methods: Data from 10 CF centers in Australia, Europe, and North America were collected retrospectively. A total of 510 patients completed a cycle CPET between January 2000 and December 2007, of which 433 fulfilled the criteria for a maximal effort. Time to death/lung transplantation was analyzed using Cox proportional hazards regression. In addition, phenotyping using hierarchical Ward clustering was performed to characterize high-risk subgroups.Measurements and Main Results: Cox regression showed, even after adjustment for sex, FEV1% predicted, body mass index (z-score), age at CPET, Pseudomonas aeruginosa status, and CF-related diabetes as covariates in the model, that V. o2peak in % predicted (hazard ratio [HR], 0.964; 95% confidence interval [CI], 0.944-0.986), peak work rate (% predicted; HR, 0.969; 95% CI, 0.951-0.988), ventilatory equivalent for oxygen (HR, 1.085; 95% CI, 1.041-1.132), and carbon dioxide (HR, 1.060; 95% CI, 1.007-1.115) (all P < 0.05) were significant predictors of death or lung transplantation at 10-year follow-up. Phenotyping revealed that CPET-derived measures were important for clustering. We identified a high-risk cluster characterized by poor lung function, nutritional status, and exercise capacity.Conclusions: CPET provides additional prognostic information to established predictors of death/lung transplantation in CF. High-risk patients may especially benefit from regular monitoring of exercise capacity and exercise counseling. [ABSTRACT FROM AUTHOR]

Published
2018
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32. Effects of a partially supervised conditioning programme in cystic fibrosis: an international multi-centre randomised controlled trial (ACTIVATE-CF): study protocol.

Author

Hebestreit H, Lands LC, Alarie N, Schaeff J, Karila C, Orenstein DM, Urquhart DS, Hulzebos EHJ, Stein L, Schindler C, Kriemler S, and Radtke T

Subjects
Adolescent, Anxiety psychology, Blood Glucose metabolism, Child, Cystic Fibrosis metabolism, Cystic Fibrosis physiopathology, Cystic Fibrosis psychology, Depression psychology, Feedback, Forced Expiratory Volume, Humans, Motivation, Quality of Life, Cystic Fibrosis rehabilitation, Exercise Therapy methods, Physical Conditioning, Human methods
Abstract

Background: Physical activity (PA) and exercise have become an accepted and valued component of cystic fibrosis (CF) care. Regular PA and exercise can positively impact pulmonary function, improve physical fitness, and enhance health-related quality of life (HRQoL). However, motivating people to be more active is challenging. Supervised exercise programs are expensive and labour intensive, and adherence falls off significantly once supervision ends. Unsupervised or partially supervised programs are less costly and more flexible, but compliance can be more problematic. The primary objective of this study is to evaluate the effects of a partially supervised exercise intervention along with regular motivation on forced expiratory volume in 1 s (FEV 1 ) at 6 months in a large international group of CF patients. Secondary endpoints include patient reported HRQoL, as well as levels of anxiety and depression, and control of blood sugar., Methods/design: It is planned that a total of 292 patients with CF 12 years and older with a FEV 1  ≥ 35% predicted shall be randomised. Following baseline assessments (2 visits) patients are randomised into an intervention and a control group. Thereafter, they will be seen every 3 months for assessments in their centre for one year (4 follow-up visits). Along with individual counselling to increase vigorous PA by at least 3 h per week on each clinic visit, the intervention group documents daily PA and inactivity time and receives a step counter to record their progress within a web-based diary. They also receive monthly phone calls from the study staff during the first 6 months of the study. After 6 months, they continue with the step counter and web-based programme for a further 6 months. The control group receives standard care and keeps their PA level constant during the study period. Thereafter, they receive the intervention as well., Discussion: This is the first large, international multi-centre study to investigate the effects of a PA intervention in CF with motivational feedback on several health outcomes using modern technology. Should this relatively simple programme prove successful, it will be made available on a wider scale internationally., Trial Registration: ClinicalTrials.gov Identifier: NCT01744561 ; Registration date: December 6, 2012.

Published
2018
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33. Authors' Reply.

Author

Hebestreit H, Arets HG, Aurora P, Boas S, Cerny F, Hulzebos EH, Karila C, Lands LC, Lowman JD, Swisher A, and Urquhart DS

Published
2016
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34. Hypersensitivity to cyclooxygenase inhibitory drugs in children: a study of 164 cases.

Author

Hassani A, Ponvert C, Karila C, Le Bourgeois M, De Blic J, and Scheinmann P

Subjects
Adolescent, Child, Child, Preschool, Female, Humans, Infant, Male, Risk Factors, Acetaminophen adverse effects, Aspirin adverse effects, Cyclooxygenase Inhibitors adverse effects, Drug Eruptions diagnosis, Drug Eruptions etiology, Drug Hypersensitivity diagnosis, Drug Hypersensitivity etiology, Ibuprofen administration & dosage
Abstract

Hypersensitivity to cyclooxygenase (COX) inhibitors is rare in children. We studied 164 children reporting 213 reactions to paracetamol, ibuprofen and/or acetylsalicylic acid (ASA). Most reactions were cutaneous, either isolated or associated with respiratory symptoms and/or anaphylaxis. Based on a convincing clinical history or positive responses in challenges with the drug(s), hypersensitivity to one or several drug(s) was diagnosed in 49.4% of the children (60, 76.5 and 23.2% of the children reporting reactions to ASA, ibuprofen and paracetamol respectively). Cross-reactivity between nonsteroidal anti-inflammatory drugs (NSAIDs) was frequent (69.1%), but only 10.6% of the NSAID-sensitive children reacted to paracetamol. In contrast, all paracetamol-sensitive children reacted to NSAIDs. Anaphylaxis, immediate and accelerated reactions, atopy, older age and chronic/recurrent urticaria were risk factors for hypersensitivity and/or cross-reactivity between ASA, ibuprofen and paracetamol. In conclusion, hypersensitivity to COX inhibitors was frequent, especially in children reporting severe and/or immediate and accelerated reactions, and in older and atopic children. Cross-reactivity was frequent, suggesting that most reactions resulted from a non allergic hypersensitivity linked to the pharmacological properties of the drugs. However, in a few children, the reactions may result from allergic hypersensitivity to selective (families of) drugs, with tolerance to other drugs.

Published
2008
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