77 results on '"Karen Wu"'
Search Results
2. Fatal Invasive Mold Infections after Transplantation of Organs Recovered from Drowned Donors, United States, 2011–2021
- Author
-
Karen Wu, Pallavi Annambhotla, Rebecca J. Free, Jana M. Ritter, Brooke Leitgeb, Brendan R. Jackson, Mitsuru Toda, Sridhar V. Basavaraju, and Jeremy A.W. Gold
- Subjects
mold ,donor-derived infection ,solid organ transplantation ,fungi ,Scedosporium ,mucormycosis ,Medicine ,Infectious and parasitic diseases ,RC109-216 - Abstract
Drowned organ donors can be exposed to environmental molds through the aspiration of water; transplantation of exposed organs can cause invasive mold infections in recipients. We describe 4 rapidly fatal cases of potentially donor-derived invasive mold infections in the United States, highlighting the importance of maintaining clinical suspicion for these infections in transplant recipients.
- Published
- 2023
- Full Text
- View/download PDF
3. Investigation of the first cluster of Candida auris cases among pediatric patients in the United States―Nevada, May 2022
- Author
-
Sophie Jones, Kaitlin Forsberg, Christopher Preste, Joe Sexton, Paige Gable, Janet Glowicz, Heather Jones, Maroya Walters, Meghan Lyman, Chidinma Njoku, Kimisha Causey, Jeanne Ruff, Dallas Smith, Karen Wu, Elizabeth Misas, Teri Lynn, Chantal Lewis, Brian Min, Fathia Osman, and Erin Archer
- Subjects
Infectious and parasitic diseases ,RC109-216 ,Public aspects of medicine ,RA1-1270 - Abstract
Background: Candida auris is a frequently drug-resistant yeast that can cause invasive disease and is easily transmitted in healthcare settings. Pediatric cases are rare in the United States, with
- Published
- 2023
- Full Text
- View/download PDF
4. Public Health Research Priorities for Fungal Diseases: A Multidisciplinary Approach to Save Lives
- Author
-
Dallas J. Smith, Jeremy A. W. Gold, Kaitlin Benedict, Karen Wu, Meghan Lyman, Alexander Jordan, Narda Medina, Shawn R. Lockhart, D. Joseph Sexton, Nancy A. Chow, Brendan R. Jackson, Anastasia P. Litvintseva, Mitsuru Toda, and Tom Chiller
- Subjects
fungal diseases ,research priorities ,fungal disease surveillance ,fungal disease diagnostic tests ,fungal disease treatment ,Biology (General) ,QH301-705.5 - Abstract
Fungal infections can cause severe disease and death and impose a substantial economic burden on healthcare systems. Public health research requires a multidisciplinary approach and is essential to help save lives and prevent disability from fungal diseases. In this manuscript, we outline the main public health research priorities for fungal diseases, including the measurement of the fungal disease burden and distribution and the need for improved diagnostics, therapeutics, and vaccines. Characterizing the public health, economic, health system, and individual burden caused by fungal diseases can provide critical insights to promote better prevention and treatment. The development and validation of fungal diagnostic tests that are rapid, accurate, and cost-effective can improve testing practices. Understanding best practices for antifungal prophylaxis can optimize prevention in at-risk populations, while research on antifungal resistance can improve patient outcomes. Investment in vaccines may eliminate certain fungal diseases or lower incidence and mortality. Public health research priorities and approaches may vary by fungal pathogen.
- Published
- 2023
- Full Text
- View/download PDF
5. High Frequency of Self-Diagnosis and Self-Treatment in a Nationally Representative Survey about Superficial Fungal Infections in Adults—United States, 2022
- Author
-
Kaitlin Benedict, Jeremy A. W. Gold, Karen Wu, and Shari R. Lipner
- Subjects
mycoses ,tinea ,tinea unguium ,tinea corporis ,ringworm ,onychomycosis ,Biology (General) ,QH301-705.5 - Abstract
Data about the prevalence, diagnosis, treatment, and public knowledge of superficial fungal infections in the United States are scarce. These infections are a growing concern given the emergence of antifungal drug resistance. We analyzed data from a national survey of nearly 6000 U.S. adults. Overall, 114 (2.7%) participants reported having ringworm and 415 (10.0%) reported a fungal nail infection in the past 12 months; 61.4% of participants with any superficial fungal infection were self-diagnosed. Most patients (55.5%) used over-the-counter antifungals. The common nature of superficial fungal infections and the high rates of self-diagnosis and treatment indicate that community education about these infections should be considered a public health priority.
- Published
- 2022
- Full Text
- View/download PDF
6. Healthcare Provider Testing Practices for Tinea and Familiarity with Antifungal-Drug-Resistant Tinea—United States, 2022
- Author
-
Kaitlin Benedict, Karen Wu, and Jeremy A. W. Gold
- Subjects
tinea ,ringworm ,dermatophytosis ,diagnosis ,drug resistance ,fungal ,Biology (General) ,QH301-705.5 - Abstract
Tinea, a dermatophyte fungal infection, is a common outpatient complaint that is easily misdiagnosed by visual inspection. Antifungal-drug-resistant tinea is an emerging global public health problem, with several cases reported in the United States. We analyzed data from a Spring 2022 web-based survey of healthcare provider attitudes and practices. Among 1500 healthcare providers, only 20.1% reported typically using diagnostic testing for tinea, and 19.5% reported clinical experience with drug-resistant tinea. Drug-resistant tinea may be more widespread than previously recognized. However, the low frequency of diagnostic testing indicates potential misunderstanding or misdiagnosis of drug-resistant tinea and missed opportunities to detect drug-resistant cases.
- Published
- 2022
- Full Text
- View/download PDF
7. Use of the Behavior Assessment Tool in 18 Pilot Residency Programs
- Author
-
April D. Armstrong, MD, FAOA, Julie Agel, MA, Matthew D. Beal, MD, FAOA, Michael S. Bednar, MD, FAOA, Michelle S. Caird, MD, FAOA, James E. Carpenter, MD, FAOA, Stuart T. Guthrie, MD, FAOA, Paul Juliano, MD, FAOA, Matthew Karam, MD, FAOA, Dawn LaPorte, MD, FAOA, J. Lawrence Marsh, MD, FAOA, Joshua C. Patt, MD, FAOA, Terrance D. Peabody, MD, FAOA, Karen Wu, MD, FAOA, David F. Martin, MD, FAOA, John J. Harrast, MS, and Ann E. Van Heest, MD, FAOA
- Subjects
Orthopedic surgery ,RD701-811 - Abstract
Update. This article was updated on March 17, 2022, because of previous errors on pages 1, 4, 5, 6, and 7. In the Abstract, Results, and Discussion sections, the specificity of the ABOS Behavior Assessment Tool that had read “57%” and “57% (95% CI 52% to 62%)” now reads “51%” and “51% (95% CI 45% to 56%).” In the Abstract, “1,012 evaluators” now reads “1,016 evaluators” and “431 residents” now reads “428 residents.” In the Results section entitled “Evaluation Results per Resident,” the sentence that had read “The domain with the greatest number of residents exhibiting low scores was ethical behavior.” now reads “The domain with the greatest number of residents exhibiting low scores was interaction.” In the Discussion section on pages 6 and 7, the number of residents with low scores in at least one domain that had read “176” now reads “196.” In Table III, the title that had read “Behavior Evaluations Completed by Resident Year in Training Source” now reads “Behavior Evaluations Completed by Resident Year in Training.” In Table VII, the column head that had read “No. of Residents with >2 Low Scores within the Same Domain” now reads “No. of Residents with ≥2 Low Scores within the Same Domain.” Also in Table VII, in columns 2 and 3, the values that had read “26 (6%), 23 (5%), 19 (4%), 18 (4%), and 20 (5%)” now read “32 (8%), 61 (14%), 63 (15%), 57 (13%), and 59 (14%).” In Table VIII, the column head that had read “No. of Baseline Professionalism PD Assessment Low Score Residents (N = 32) Also with Low Scores on the Behavior Tool by at least 2 Evaluators” now reads “No. of Baseline Professionalism PD Assessment Low Score Residents (N = 32) Also with Low Scores on the Behavior Tool.” In Table IX, the title that had read “Number of Low Domain Scores by at least 2 Evaluators for Low Baseline Professionalism PD Assessment Score Residents (n = 32)*” now reads “Number of Low Domain Scores for Low Baseline Professionalism PD Assessment Score Residents (n = 32)*”. Also, the values in the table that had read “6, 3, 2, 2, 6, 13” now read “7, 2, 1, 3, 5, 14.” In Table X, the title that had read “Specificity and Sensitivity of the ABOS Behavior Tool Compared with PD Baseline Assessment for All Participating Residents (n = 440)*” now reads “Specificity and Sensitivity of the ABOS Behavior Tool Compared with PD Baseline Assessment for All Participating Residents (n = 428)*.” Also in Table X, in the right column entitled “PD Baseline Assessment High Score (3 or 4),” the values that had read “176” and “232” now read “196” and “200,” respectively. Finally, a supplementary data file has now been included with the article that contains results that portray resident performance with at least two low scores in one domain by at least two different evaluators. An erratum has been published: JBJS Open Access. 2022 Mar 31;7(1):e20.00103ER. Background:. The purpose of this study was to determine the feasibility and evaluate the effectiveness of the American Board of Orthopaedic Surgery Behavior Tool (ABOSBT) for measuring professionalism. Methods:. Through collaboration between the American Board of Orthopaedic Surgery and American Orthopaedic Association's Council of Residency Directors, 18 residency programs piloted the use of the ABOSBT. Residents requested assessments from faculty at the end of their clinical rotations, and a 360° request was performed near the end of the academic year. Program Directors (PDs) rated individual resident professionalism (based on historical observation) at the outset of the study, for comparison to the ABOSBT results. Results:. Nine thousand eight hundred ninety-two evaluations were completed using the ABOSBT for 449 different residents by 1,016 evaluators. 97.6% of all evaluations were scored level 4 or 5 (high levels of professional behavior) across all of the 5 domains. In total, 2.4% of all evaluations scored level 3 or below reflecting poorer performance. Of 428 residents, the ABOSBT identified 26 of 32 residents who were low performers (2 or more < level 3 scores in a domain) and who also scored “below expectations” by the PD at the start of the pilot project (81% sensitivity and 51% specificity), including 13 of these residents scoring poorly in all 5 domains. Evaluators found the ABOSBT was easy to use (96%) and that it was an effective tool to assess resident professional behavior (81%). Conclusions:. The ABOSBT was able to identify 2.4% low score evaluations (
- Published
- 2020
- Full Text
- View/download PDF
8. Factors influencing the number of applications submitted per applicant to orthopedic residency programs
- Author
-
Elissa S. Finkler, Harold A. Fogel, Ellen Kroin, Stephanie Kliethermes, Karen Wu, Lukas M. Nystrom, and Adam P. Schiff
- Subjects
orthopedic surgery ,residency application ,National Residency Matching Program ,United States Medical Licensing Exam ,Special aspects of education ,LC8-6691 ,Medicine (General) ,R5-920 - Abstract
Background: From 2002 to 2014, the orthopedic surgery residency applicant pool increased by 25% while the number of applications submitted per applicant rose by 69%, resulting in an increase of 109% in the number of applications received per program. Objective: This study aimed to identify applicant factors associated with an increased number of applications to orthopedic surgery residency programs. Design: An anonymous survey was sent to all applicants applying to the orthopedic surgery residency program at Loyola University. Questions were designed to define the number of applications submitted per respondent as well as the strength of their application. Of 733 surveys sent, 140 (19.1%) responses were received. Setting: An academic institution in Maywood, IL. Participants: Fourth-year medical students applying to the orthopedic surgery residency program at Loyola University. Results: An applicant's perception of how competitive he or she was (applicants who rated themselves as ‘average’ submitted more applications than those who rated themselves as either ‘good’ or ‘outstanding’, p=0.001) and the number of away rotations (those who completed >2 away rotations submitted more applications, p=0.03) were significantly associated with an increased number of applications submitted. No other responses were found to be associated with an increased number of applications submitted. Conclusion: Less qualified candidates are not applying to significantly more programs than their more qualified counterparts. The increasing number of applications represents a financial strain on the applicant, given the costs required to apply to more programs, and a time burden on individual programs to screen increasing numbers of applicants. In order to stabilize or reverse this alarming trend, orthopedic surgery residency programs should openly disclose admission criteria to prospective candidates, and medical schools should provide additional guidance for candidates in this process.
- Published
- 2016
- Full Text
- View/download PDF
9. Interaction effects of BDNF and COMT genes on resting-state brain activity and working memory
- Author
-
Wen Chen, Chunhui Chen, Mingrui Xia, Karen Wu, Chuansheng Chen, Qinghua He, Gui Xue, Wengjing Wang, Yong He, and Qi Dong
- Subjects
BDNF ,working memory ,regional homogeneity ,COMT gene ,interaction effect ,Neurosciences. Biological psychiatry. Neuropsychiatry ,RC321-571 - Abstract
Catechol-O-methyltransferase (COMT) and brain-derived neurotrophic factor (BDNF) genes have been found to interactively influence working memory (WM) as well as brain activation during WM tasks. However, whether the two genes have interactive effects on resting-state activities of the brain and whether these spontaneous activations correlate with WM are still unknown. This study included behavioral data from WM tasks and genetic data (COMT rs4680 and BDNF Val66Met) from 417 healthy Chinese adults and resting-state fMRI data from 298 of them. Significant interactive effects of BDNF and COMT were found for WM performance as well as for resting-state regional homogeneity (ReHo) in WM-related brain areas, including the left medial frontal gyrus (lMeFG), left superior frontal gyrus (lSFG), right superior and medial frontal gyrus (rSMFG), right medial orbitofrontal gyrus (rMOFG), right middle frontal gyrus (rMFG), precuneus, bilateral superior temporal gyrus, left superior occipital gyrus, right middle occipital gyrus and right inferior parietal lobule. Simple effects analyses showed that compared to other genotypes, subjects with COMT-VV/BDNF-VV had higher WM and lower ReHo in all five frontal brain areas. The results supported the hypothesis that COMT and BDNF polymorphisms influence WM performance and spontaneous brain activity (i.e., ReHo).
- Published
- 2016
- Full Text
- View/download PDF
10. Identification and characterization of proteins involved in nuclear organization using Drosophila GFP protein trap lines.
- Author
-
Margaret Rohrbaugh, Alyssia Clore, Julia Davis, Sharonta Johnson, Brian Jones, Keith Jones, Joanne Kim, Bramwel Kithuka, Krystal Lunsford, Joy Mitchell, Brian Mott, Edward Ramos, Maza R Tchedou, Gilbert Acosta, Mark Araujo, Stuart Cushing, Gabriel Duffy, Felicia Graves, Kyler Griffin, B V Gurudatta, Deaundra Jackson, Denis Jaimes, Kendall Jamison, Khali Jones, Dhaujee Kelley, Marquita Kilgore, Derica Laramore, Thuy Le, Bakhtawar Mazhar, Muhammad M Mazhar, Britney McCrary, Teanndras Miller, Celethia Moreland, Alex Mullins, Elyas Munye, Sheila Okoorie, Elisha Pittman, Nikkita Roberts, De'Warren Rose, Alex Rowland, Anwar Shagarabi, Jamela Smith, Tayler Stallworth, Nicole Stroud, Elizabeth Sung, Kai Sung, Naomi Takenaka, Eduardo Torre, Jarvis Veira, Kim Vu, William Wagstaff, Ashley M Wood, Karen Wu, Jingping Yang, and Victor G Corces
- Subjects
Medicine ,Science - Abstract
Strains from a collection of Drosophila GFP protein trap lines express GFP in the normal tissues where the endogenous protein is present. This collection can be used to screen for proteins distributed in the nucleus in a non-uniform pattern.We analyzed four lines that show peripheral or punctate nuclear staining. One of these lines affects an uncharacterized gene named CG11138. The CG11138 protein shows a punctate distribution in the nuclear periphery similar to that of Drosophila insulator proteins but does not co-localize with known insulators. Interestingly, mutations in Lamin proteins result in alterations in CG11138 localization, suggesting that this protein may be a novel component of the nuclear lamina. A second line affects the Decondensation factor 31 (Df31) gene, which encodes a protein with a unique nuclear distribution that appears to segment the nucleus into four different compartments. The X-chromosome of males is confined to one of these compartments. We also find that Drosophila Nucleoplasmin (dNlp) is present in regions of active transcription. Heat shock leads to loss of dNlp from previously transcribed regions of polytene chromosome without redistribution to the heat shock genes. Analysis of Stonewall (Stwl), a protein previously found to be necessary for the maintenance of germline stem cells, shows that Stwl is present in a punctate pattern in the nucleus that partially overlaps with that of known insulator proteins. Finally we show that Stwl, dNlp, and Df31 form part of a highly interactive network. The properties of other components of this network may help understand the role of these proteins in nuclear biology.These results establish screening of GFP protein trap alleles as a strategy to identify factors with novel cellular functions. Information gained from the analysis of CG11138 Stwl, dNlp, and Df31 sets the stage for future studies of these proteins.
- Published
- 2013
- Full Text
- View/download PDF
11. Pay to Win or Pay to Cheat: How Players of Competitive Online Games Perceive Fairness of In-Game Purchases.
- Author
-
Guo Freeman, Karen Wu, Nicholas Nower, and Donghee Yvette Wohn
- Published
- 2022
- Full Text
- View/download PDF
12. Prevention Techniques Have Had Minimal Impact on the Population Rate of Prosthetic Joint Infection for Primary Total Hip and Knee Arthroplasty: A National Database Study
- Author
-
Michael P. Murphy, Ashley E. MacConnell, Cameron J. Killen, Daniel R. Schmitt, Karen Wu, William J. Hopkinson, and Nicholas M. Brown
- Subjects
Orthopedics and Sports Medicine - Published
- 2023
- Full Text
- View/download PDF
13. Artificial Intelligence Autonomously Measures Cup Orientation, Corrects for Pelvis Orientation, and Identifies Retroversion From Antero-Posterior Pelvis Radiographs
- Author
-
Michael P. Murphy, Cameron J. Killen, Sara R. Winfrey, Daniel R. Schmitt, William J. Hopkinson, Karen Wu, and Nicholas M. Brown
- Subjects
Orthopedics and Sports Medicine - Published
- 2023
- Full Text
- View/download PDF
14. The cortical surface area of the insula mediates the effect of DBH rs7040170 on novelty seeking.
- Author
-
Jin Li, Yue Cui 0005, Karen Wu, Bing Liu 0008, Yun Zhang, Chao Wang, and Tianzi Jiang
- Published
- 2015
- Full Text
- View/download PDF
15. Interpersonal conflict increases interpersonal neural synchronization in romantic couples
- Author
-
Faxin Zhou, Yuhang Long, Karen Wu, Hui Zhao, Yu Zhai, Chunming Lu, Lifen Zheng, Chuansheng Chen, and Siyuan Zhou
- Subjects
Communication ,Cognitive Neuroscience ,media_common.quotation_subject ,Emotions ,Brain ,Interpersonal communication ,Romance ,Social relation ,Arousal ,Developmental psychology ,Conflict, Psychological ,Cellular and Molecular Neuroscience ,Nonverbal communication ,Friendship ,Relationship Type ,Humans ,Interpersonal Relations ,Valence (psychology) ,Psychology ,media_common - Abstract
Previous studies on dual-brain social interaction have shown different patterns of interpersonal neural synchronization (INS) between conflictual and supportive interactions, but the role of emotion in the dual-brain mechanisms of such interactions is not well understood. Furthermore, little is known about how the dual-brain mechanisms are affected by relationship type (e.g., romantic relationship vs. friendship) and interaction mode (e.g., verbal vs. nonverbal). To elaborate on these issues, this study used functional near-infrared spectroscopy to collect hemodynamic signals from romantic couples and cross-sex friends while they were discussing conflictual, neutral, or supportive topics. For the couples but not the friends, INS between the sensorimotor cortex of both participants was greater when discussing the conflictual topic than when discussing the supportive topic. INS was positively correlated with the arousal level but not the valence level of communication contents. INS was also positively correlated with interpersonal physiological synchronization based on galvanic skin response, a physiological measure of arousal. Furthermore, the differences in INS between the conflictual and supportive topics were closely associated with verbal rather than nonverbal behaviors. Together, these findings suggest that it is the arousal level induced by verbal interactions during interpersonal conflicts that increases romantic couples’ INS.
- Published
- 2021
- Full Text
- View/download PDF
16. Spread of Sporothrix spp. through respiratory droplets from infected cats: A potential route of transmission
- Author
-
Fernanda de Andrade Galliano Daros Bastos, Regielly Caroline Raimundo Cognialli, Marconi Rodrigues de Farias, Fabiana dos Santos Monti, Karen Wu, and Flávio Queiroz-Telles
- Subjects
Infectious Diseases ,Sporothrix ,Zoonoses ,Cats ,Humans ,Animals ,Respiratory Aerosols and Droplets ,General Medicine ,Cat Diseases ,Brazil ,Sporotrichosis - Abstract
Cases of cat-transmitted sporotrichosis in Brazil have increased in recent years. We collected respiratory secretions expelled while sneezing from 28 cats diagnosed with sporotrichosis. We identified the presence of Sporothrix spp. in respiratory droplets expelled in the sneeze of infected cats. The results raise concerns about a new transmission route for cat-transmitted sporotrichosis. Physicians who diagnose and treat human cases of sporotrichosis should be aware of this potential new transmission method to improve clinical suspicion. Approximately half of patients with granulomatous conjunctival sporotrichosis did not report experiencing traumatic injury from cats.Cat-transmitted sporotrichosis is a zoonosis in geographic expansion from Brazil to other Latin American countries and is considered a public health problem. Data suggest that transmission can occur through the sneeze of an infected cat. The One Health approach is necessary to control the disease.
- Published
- 2022
- Full Text
- View/download PDF
17. Investigation of a Prolonged and Large Outbreak of Healthcare-Associated Mucormycosis Cases in an Acute Care Hospital—Arkansas, June 2019–May 2021
- Author
-
Alexander Jordan, Allison E James, Jeremy A W Gold, Karen Wu, Janet Glowicz, Frankie Wolfe, Keyur Vyas, Anastasia Litvintseva, Lalitha Gade, Hazel Liverett, Mary Alverson, Mary Burgess, Amy Wilson, Ruoran Li, Isaac Benowitz, Trent Gulley, Naveen Patil, Rohan Chakravorty, Winston Chu, Atul Kothari, Brendan R Jackson, Kelley Garner, and Mitsuru Toda
- Subjects
Infectious Diseases ,Oncology ,Major Article - Abstract
Background Outbreaks of healthcare-associated mucormycosis (HCM), a life-threatening fungal infection, have been attributed to multiple sources, including contaminated healthcare linens. In 2020, staff at Hospital A in Arkansas alerted public health officials of a potential HCM outbreak. Methods We collected data on patients at Hospital A who had invasive mucormycosis during January 2017–June 2021 and calculated annual incidence of HCM (defined as mucormycosis diagnosed within ≥7 days after hospital admission). We performed targeted environmental assessments, including linen sampling at the hospital, to identify potential sources of infection. Results During the outbreak period (June 2019–June 2021), 16 patients had HCM; clinical features were similar between HCM patients and non-HCM patients. Hospital-wide HCM incidence (per 100 000 patient-days) increased from 0 in 2018 to 3 in 2019 and 6 in 2020. For the 16 HCM patients, the most common underlying medical conditions were hematologic malignancy (56%) and recent traumatic injury (38%); 38% of HCM patients died in-hospital. Healthcare-associated mucormycosis cases were not epidemiologically linked by common procedures, products, units, or rooms. At Hospital A and its contracted offsite laundry provider, suboptimal handling of laundered linens and inadequate environmental controls to prevent mucormycete contamination were observed. We detected Rhizopus on 9 (9%) of 98 linens sampled at the hospital, including on linens that had just arrived from the laundry facility. Conclusions We describe the largest, single-center, HCM outbreak reported to date. Our findings underscore the importance of hospital-based monitoring for HCM and increased attention to the safe handling of laundered linens.
- Published
- 2022
18. A level playing field: No competitive advantage of conception risk in speed‐dating
- Author
-
Chuansheng Chen and Karen Wu
- Subjects
Attractiveness ,Microeconomics ,Level playing field ,Mate choice ,Speed dating ,Animal Science and Zoology ,Psychology ,Competitive advantage ,Attraction ,Ecology, Evolution, Behavior and Systematics - Published
- 2021
- Full Text
- View/download PDF
19. The area method for measuring acetabular cup anteversion: An accurate and autonomous solution
- Author
-
Cameron J. Killen, Steven J Ralles, Albert Song, Nicholas M. Brown, Karen Wu, and Michael P. Murphy
- Subjects
Cup orientation ,030222 orthopedics ,Reproducibility ,business.industry ,Radiography ,Triaxial accelerometer ,Image processing ,Cup anteversion ,Accelerometer ,Article ,03 medical and health sciences ,0302 clinical medicine ,Medicine ,Orthopedics and Sports Medicine ,Computer vision ,030212 general & internal medicine ,Artificial intelligence ,business ,Total hip arthroplasty - Abstract
Several radiological methods of measuring anteversion of the acetabular component after total hip arthroplasty have been described, all time-consuming and with varying reproducibility. This study aimed to compare the recently proposed Area method to true cup anteversion as determined by an accelerometer. This study further applied this method programmatically to autonomously determine radiographic cup orientation using two computer programs, then compared these results to hand and accelerometer measurements. 160 anteroposterior pelvis radiographs were taken of a standard Sawbones® pelvis fitted with a total hip arthroplasty system. The acetabular cup was re-oriented between each radiograph, with anteversion ranging from 0° to 90°. An accelerometer was mounted to the cup to measure true cup anteversion. Radiographic anteversion was independently measured via three methods: by hand, linear image processing, and machine learning. Measurements were compared to triaxial accelerometer recordings. Coefficient of determination (R2) was found to be 0.997, 0.991, and 0.989 for hand measurements, the machine learning, and linear image processing, respectively. The machine learning program and hand measurements overestimated anteversion by 0.70° and 0.02° respectively. The program using linear techniques underestimated anteversion by 5.02°. Average runtime was 0.03 and 0.59 s for the machine learning and linear image processing program, respectively. The machine learning program averaged within 1° of cup orientation given a true cup anteversion less than 51°, and within 2° given an anteversion less than 85°. The Area method showed great accuracy and reliability with hand measurements compared to true anteversion. The results of this study support the use of machine learning for accurate, timely, autonomous assessment of cup orientation.
- Published
- 2021
- Full Text
- View/download PDF
20. Notes from the Field: Cluster of Blastomycosis Among Neighborhood Residents — St. Croix County, Wisconsin, 2022
- Author
-
Hannah E. Segaloff, Karen Wu, Summer Shaw, Elizabeth M. Klasen, Lori Peterson, Sue Lindberg, Samantha L. Williams, Andrew Wiese, Yvonne M. Bellay, Meredith Smith, Kelli Engen, Mitsuru Toda, and Suzanne Gibbons-Burgener
- Subjects
Health (social science) ,Health Information Management ,Epidemiology ,Health, Toxicology and Mutagenesis ,General Medicine - Published
- 2023
- Full Text
- View/download PDF
21. P462 Spread of sporothrix brasiliensis from the sneeze of infected cats: a potential novel route of transmission
- Author
-
Fernanda Bastos, Marconi Farias, Fabiana Monti, Regielly Cognialli, Lili Lopuch, Adriana Gabriel, Vania Vicente, Emanuel Razzolini, Karen Wu, and Flavio Queiroz-telles
- Subjects
Infectious Diseases ,General Medicine - Abstract
Poster session 3, September 23, 2022, 12:30 PM - 1:30 PM Objectives Cat-transmitted sporotrichosis (CTS), caused by Sporothrix brasiliensis, is an emerging fungal disease that has become a major public health concern in Brazil. Transmission of CTS usually occurs through the implantation (e.g., scratches or bites) of infectious yeast from feline Sporothrix lesions. Recent reports on transmission events have suggested that S. brasiliensis might be transmitted through feline respiratory droplets created while sneezing. The aim of our study is to determine whether infectious respiratory secretions are expelled when cats with sporotrichosis sneeze. Methods We collected respiratory secretions expelled while sneezing from 28 cats diagnosed with sporotrichosis. We placed a Mycosel agar plate, a fungal culture medium, in front of the animals’ nostrils and used a nasal swab to stimulate sneezing (Fig. 1). Samples were incubated at 28-30°C for 4 weeks in the Mycology laboratory of Hospital de Clinicas. Molecular identification of the isolates was performed by sequencing the calmodulin gene. The infected cats enrolled in the study were subsequently treated at the School Veterinary Clinic of the Pontifical Catholic University of Paraná, a referral hospital for the treatment of feline sporotrichosis. Results Out of the 28 respiratory samples collected, 20 (70%) had evidence of fungal growth morphologically consistent with Sporothrix. Sequencing of all isolates identified Sporothrix brasiliensis (Fig. 2). Conclusion We identified a possible novel route of transmission of Sporothrix spp. through infectious feline respiratory secretions expelled during sneezing. The respiratory droplets created by a sneeze could contain viable Sporothrix yeast that could infect humans and other animals after mucosal exposure. One health partner and collaborator such as veterinarians, physicians, health authorities, epidemiologists, and fungal disease researchers should be made aware of the potential spread of Sporothrix through respiratory droplets and sneezing to prevent and control the further spread of CTS. To prevent cat-to-human transmission of Sporothrix brasiliensis, personal protective equipment (PPE) should be worn while handling a cat with suspected sporotrichosis. Veterinarians, veterinary clinic employees, students, and pet shop owners are at increased risk due to their professions. Veterinary care frequently involves procedures that encourage respiratory droplets (e.g., nasal swabs); restraint and other close contact may directly expose staff to infectious secretions. Because this study identified viable yeast in respiratory droplets from sneezing, decontamination and disinfection of exposed surfaces is increasingly important, as surfaces and objects can serve as fomites for Sporothrix. Physicians who diagnose and treat human cases of sporotrichosis should be aware of this new transmission method to improve clinical suspicion, diagnosis, and treatment for sporotrichosis. Approximately half of the human patients with conjunctival sporotrichosis did not report experiencing traumatic injury from cats; mucosal exposure to infectious yeast is a likely alternative transmission method.
- Published
- 2022
- Full Text
- View/download PDF
22. Opportunities to improve guideline adherence for the diagnosis and treatment of onychomycosis: Analysis of commercial insurance claims data, United States
- Author
-
Jeremy A.W. Gold, Karen Wu, Brendan R. Jackson, and Kaitlin Benedict
- Subjects
Dermatology - Published
- 2022
23. No need for pedestals: Idealization does not predict better relationships among Asians
- Author
-
Bin Liu, Daiming Xiu, Chuansheng Chen, Wen Chen, Jin Li, Chunhui Chen, Karen Wu, Ellen Greenberger, Yunxin Wang, and Qi Dong
- Subjects
Social Psychology ,Asian americans ,Anthropology ,Developmental and Educational Psychology ,Idealization ,Life-span and Life-course Studies ,Psychology ,Social psychology - Published
- 2020
- Full Text
- View/download PDF
24. The Lack of Standardization of Allopathic and Osteopathic Medical School Grading Systems and Transcripts
- Author
-
Richard J. Fagan, Dane Salazar, Karen Wu, Adam Schiff, and Elizabeth Harkin
- Subjects
medicine.medical_specialty ,Students, Medical ,Standardization ,education ,Education ,03 medical and health sciences ,0302 clinical medicine ,Humans ,Medicine ,University medical ,030212 general & internal medicine ,Class rank ,Overall performance ,Grading (education) ,Schools, Medical ,business.industry ,Medical school ,Internship and Residency ,Residency program ,Reference Standards ,United States ,030220 oncology & carcinogenesis ,Family medicine ,Coursework ,Surgery ,business ,Osteopathic Medicine - Abstract
Objective The purpose of this study is to assess the variability in grading systems used by US allopathic and osteopathic medical schools across all 4 years of medical school coursework. Design Transcripts were reviewed from all participating allopathic and osteopathic medical schools for all 4 years of coursework for grading system type, the presence or absence of a key or guide, the inclusion of grade distribution within class year, inclusion of a class rank, and summary statements or evaluation systems used by the institution within the Medical Student Performance Evaluation to evaluate overall performance. Setting Loyola University Medical Center. Maywood, IL. Participants Transcripts were reviewed for 144 out of existing 147 allopathic medical schools (97.9%) and 37 out of 39 existing osteopathic medical schools (94.8%). Results For allopathic schools, grading system distribution for preclinical years was—41.6% Pass/Fail, 40.3% Honors, 13.2% Letter; while grading system distribution for clinical years was—78.5% Honors, 15.9% Letter. Only 35.4% of allopathic medical schools used the same system for all 4 years, while the remaining schools used a different system for preclinical and clinical years. For osteopathic medical schools, grading system distribution for preclinical years was—45.9% Letter, 32.4% Honors, and 13.5% Pass/Fail; while grading system distribution for clinical years was—59.5% Honors and 29.7% Letter (Table 4). Overall, 56.7% of osteopathic programs used the same system for all 4 years, while the remaining schools used a different system for the preclinical years than the clinical years. Variability also existed within each of these broader grading system categories (Table 1, Table 3). Conclusions Our results highlight the variability in grading systems used by medical schools both among programs and between preclinical and clinical years. From the residency program perspective, the lack of consistent, objective comparisons between school transcripts makes comparing applicants from different institutions difficult.
- Published
- 2020
- Full Text
- View/download PDF
25. Gender Differences in Program Factors Important to Applicants When Evaluating Orthopaedic Surgery Residency Programs
- Author
-
Joseph Romano, Karen Wu, Ellen Kroin, Aoi Shimomura, Adam Schiff, and Dana Garbarski
- Subjects
Adult ,Male ,030222 orthopedics ,medicine.medical_specialty ,Medical education ,Faculty, Medical ,media_common.quotation_subject ,Field (Bourdieu) ,Internship and Residency ,Orthopedic Surgeons ,General Medicine ,03 medical and health sciences ,Sex Factors ,0302 clinical medicine ,Surveys and Questionnaires ,Orthopedic surgery ,medicine ,Humans ,Female ,030212 general & internal medicine ,Psychology ,Minority Groups ,Original Research ,Diversity (politics) ,media_common - Abstract
Background Despite specialty-driven efforts to improve diversity in the field, few women apply to orthopaedic residency, and women are unevenly distributed among programs. There is little evidence-based information on factors that may attract female applicants. Objective This study aims to identify factors important to applicants when evaluating orthopaedic residency programs and to identify gender-specific differences. Methods All applicants to a single orthopaedic surgery residency program in the 2017 Match were asked to fill out an anonymous survey. Respondents rated the importance of 35 factors when evaluating orthopaedic residency programs. The percentage of highly rated factors was calculated. Statistical analysis was performed for each factor to assess differences by gender. Results Of 1013 applicants who applied to orthopaedic surgery residency in 2017, 815 (80%) applied to our program, and 218 (27%) completed the survey. The most important factors when evaluating a residency program for both genders were (1) perceptions of current residents; (2) interactions with members of the program; (3) program reputation and fellowship placement; (4) geographic location; and (5) impressions after rotation at a program. Female applicants rated the presence of female and minority residents and faculty and program reputation for gender and racial/ethnic diversity higher than male applicants. Conclusions When choosing an orthopaedic surgery residency program, women more often reported the presence of female residents and faculty, program reputation for gender diversity, reputation for racial/ethnic diversity, presence of minority residents and faculty, and their personal interactions with members of the program as important factors.
- Published
- 2019
- Full Text
- View/download PDF
26. A precise method for determining acetabular component anteversion after total hip arthroplasty
- Author
-
Michael P. Murphy, William Hopkinson, Steven J Ralles, Karen Wu, Cameron J. Killen, and Nicholas M. Brown
- Subjects
Orthodontics ,Reproducibility ,business.industry ,Arthroplasty, Replacement, Hip ,Reproducibility of Results ,Acetabulum ,Femur Head ,Radiography ,Bone Anteversion ,Acetabular component ,Radiological weapon ,Humans ,Medicine ,Orthopedics and Sports Medicine ,Surgery ,Diagnosis, Computer-Assisted ,Hip Prosthesis ,Tomography, X-Ray Computed ,business ,Retrospective Studies ,Total hip arthroplasty - Abstract
Aims Several radiological methods of measuring anteversion of the acetabular component after total hip arthroplasty (THA) have been described. These are limited by low reproducibility, are less accurate than CT 3D reconstruction, and are cumbersome to use. These methods also partly rely on the identification of obscured radiological borders of the component. We propose two novel methods, the Area and Orthogonal methods, which have been designed to maximize use of readily identifiable points while maintaining the same trigonometric principles. Patients and Methods A retrospective study of plain radiographs was conducted on 160 hips of 141 patients who had undergone primary THA. We compared the reliability and accuracy of the Area and Orthogonal methods with two of the current leading methods: those of Widmer and Lewinnek, respectively. Results The 160 anteroposterior pelvis films revealed that the proposed Area method was statistically different from those described by Widmer and Lewinnek (p < 0.001 and p = 0.004, respectively). They gave the highest inter- and intraobserver reliability (0.992 and 0.998, respectively), and took less time (27.50 seconds (sd 3.19); p < 0.001) to complete. In addition, 21 available CT 3D reconstructions revealed the Area method achieved the highest Pearson’s correlation coefficient (r = 0.956; p < 0.001) and least statistical difference (p = 0.704) from CT with a mean within 1° of CT-3D reconstruction between ranges of 1° to 30° of measured radiological anteversion. Conclusion Our results support the proposed Area method to be the most reliable, accurate, and speedy. They did not support any statistical superiority of the proposed Orthogonal method to that of the Widmer or Lewinnek method. Cite this article: Bone Joint J 2019;101-B:1042–1049.
- Published
- 2019
- Full Text
- View/download PDF
27. Factors Associated with Participation in Elementary School-Based SARS-CoV-2 Testing - Salt Lake County, Utah, December 2020-January 2021
- Author
-
Adam L. Hersh, Snigdha Vallabhaneni, Hannah L Kirking, Angela Dunn, Alison T. Milne, Rebecca B. Hershow, Jacqueline E. Tate, Nathan LaCross, Mary Hill, Nathaniel M. Lewis, Victoria T Chu, Ilene Risk, and Karen Wu
- Subjects
medicine.medical_specialty ,Health (social science) ,Epidemiology ,Health, Toxicology and Mutagenesis ,education ,Ethnic group ,Health Information Management ,Saliva testing ,Utah ,medicine ,Humans ,Full Report ,Statistics & numerical data ,Child ,School Health Services ,Schools ,business.industry ,COVID-19 ,General Medicine ,Outreach ,Specimen collection ,Socioeconomic Factors ,Family medicine ,COVID-19 Nucleic Acid Testing ,Contact Tracing ,business ,Contact tracing ,Health department - Abstract
During December 3, 2020-January 31, 2021, CDC, in collaboration with the University of Utah Health and Economic Recovery Outreach Project,* Utah Department of Health (UDOH), Salt Lake County Health Department, and one Salt Lake county school district, offered free, in-school, real-time reverse transcription-polymerase chain reaction (RT-PCR) saliva testing as part of a transmission investigation of SARS-CoV-2, the virus that causes COVID-19, in elementary school settings. School contacts† of persons with laboratory-confirmed SARS-CoV-2 infection, including close contacts, were eligible to participate (1). Investigators approached parents or guardians of student contacts by telephone, and during January, using school phone lines to offer in-school specimen collection; the testing procedures were explained in the preferred language of the parent or guardian. Consent for participants was obtained via an electronic form sent by e-mail. Analyses examined participation (i.e., completing in-school specimen collection for SARS-CoV-2 testing) in relation to factors§ that were programmatically important or could influence likelihood of SARS-CoV-2 testing, including race, ethnicity, and SARS-CoV-2 incidence in the community (2). Crude prevalence ratios (PRs) were calculated using univariate log-binomial regression.¶ This activity was reviewed by CDC and was conducted consistent with federal law and CDC policy.*.
- Published
- 2021
28. Interventions to improve system-level coproduction in the Cystic Fibrosis Learning Network
- Author
-
Rachel Gordon, Lillian O’Leary, Gregory Sawicki, Don B Sanders, David Miller, Peter J Murphy, Michael Seid, John Dickinson, Mary Lester, Catherine Hopkins, Adrienne Savant, Rebekah Brown, Preeti Sharma, Christian Merlo, Michelle Roberts, Kathryn A Sabadosa, David Hansen, Peter Michelson, Amy Filbrun, Jordan Dunitz, Christopher M Siracusa, Thida Ong, Stacy Bichl, Ahmet Uluer, Joanne Cullina, Michael Powers, Rhonda List, Lindsay Somerville, Lauren Williamson, Dana Albon, Hossein Sadeghi, Clement Ren, Thomas Keens, Nicholas Antos, Fadi Asfour, Mike Price, Kristen Nowak, Robert Balk, Erin Moore, Prigi Varghese, Cori Daines, Glenda Drake, Amy Lucero, Amanda Sharpe, Lindsey McMahon, Meghan Murray, Meghana Sathe, Traci Liberto, Rachel Linnemann, Pornchai Tirakitsoontorn, Maivy Sou, Michael Schechter, Andrea Molzhon, Karen Wunschel, Lisa A Mullen, Kyle Traver, Travis Burgett, Alex Gifford, Nicola Felicetti, Heidi Dolan, Tracey Gendreau, Danielle Beachler, Shine-Ann Pai, Stephanie Robbins, Ben McCullar, Lauren Mitchell, Andrew Scaljon, Stefanie Rushing, Golnar Raissi, Bean Corcoran, Michelle Prickett, Rachel Nelson, Stacy Allen, Lisa Greene, Sara Renschen, Betsy Price, Catherine Kier, Teresa Carney, Sandy Corr, Barbara Leyva, Jillian Salvatore, George M Solomon, Julianna Bailey, James Lawlor, Samya Z Nasr, Rebekah Raines, Catherine Enochs, Kristen Jesse, Jonathan Flath, Mackenzie Wharram, James Tolle, Susan Eastman, Nauman Chaudary, Mahsa Farsad, Kimberly Wingo, Kathryn Moffett, Erin Brozik, Paige Krack, Kevin Martin, Laura Roth, Joshua Wang, Sarah Dykes, Erin Newbill, Misty Thompson, Danielle Poulin, Breck Gamel, Srujana Bandla, David W Davison, Lindsay Silva, Raouf Amin, Maria Britto, Anna Saulitis, Kate Barnico, Cindy Murphy, Amanda Lemieux, Georgia Dangel, Melanie Lawrence, Danielle Goetz, Danielle Woerner, Megan Whelan, Katelyn Violanti, Susan Attel, Alexia Hernández Cargal, Kelly Clute, Olivia Ries, Susan Gage, Bridget Kominek, Kristin Lawrence, Megan Martin, Jessica Roach, Errin Newman, Phillip Vaden, Esther Giezendanner, Marsha Triana, Sujal Rangwalla, Meghann Weil, Randy Hunt, Emily Walker, Caroline Starnes, Kendra Adderhold, Megan Barker, Johanna Zea-Hernandez, Beth Debri, Ann Kaiser, Cindy Brown, Pi Chun Cheng, Jana Yeley, Laura Jay-Ballinger, Julian McConnie, Meghana Malapaka, Perry Aulie, Ginger Birnbaum, Cynthia Driskill, Janerisa Encarnacion, Amanda Oswald, Stephanie Fullmer, Anthony Fashoda, Laura Steinhaus, Maureen Tinley, Jame’ Vajda, Janine Cassidy, Mey Lee, Megan Akers, Susan Whitmore, Christian Santaniello, Robert Abdullah, Bryan Garcia, Cameron Crenshaw, Kandice Amos, Veronica Indihar, Lisa Shively, Anissa Hostetter, Angela Oder, Brandi Morgan, Kayla Hubley, Deborah K Froh, Holly Carroll-Owen, Lauren Miller Ahrens, Brielle Evangelista, Lucy Gettle, Tracie O'Sullivan, Autumn Bonstein, Stacey Miller, Angela Bender, Billie Jo Bennett, John Palla, Cathy O'Malley, Maria Dowell, Allison Fitch-Markham, Chladd Ford, Carolyn Heyman, Terri Laguna, Debbie Benitez, Lynn Fukushima, Martha Markovitz, Adupa Rao, Gregory Storm, Vai Jun Lam, John Mercer, Cori Muirhead, Jeff Gold, Aaron Trimble, Gopal Allada, Wendy Palmrose, Sue Sullivan, Kim Keeling, Rob Shradar, Jill Fliege, Heidi Klasna, Janelle Sorensen, Stacy Millikan, Joe Poler, Jill Rollins, Sandy Wahl, Cristy Batten, Laura Romero, Whitney Gore, Kimberly Morse, Rocio Munter, Danieli Salinas, Sylvia Sanchez, Virginia Anderson, Jami Dunn, Stephanie Gamble, Hector Gutierrez, Kelli Lachowicz, Isabel Lowell, Cathy Mims, LaShonna Stodghill, Gabriela Oates, Amanda Phillips, Linda Russo, Staci Self, Julie Desch, Ilene Hollin, Emily Kramer-Golinkoff, Pamela Mertz, Sarah Gomez, Nancy Griffin, and Drew Warmin
- Subjects
Medicine (General) ,R5-920 - Abstract
Background Coproduction is defined as patients and clinicians collaborating equally and reciprocally in healthcare and is a crucial concept for quality improvement (QI) of health services. Learning Health Networks (LHNs) provide insights to integrate coproduction with QI efforts from programmes from various health systems.Objective We describe interventions to develop and maintain patient and family partner (PFP) coproduction, measured by PFP-reported and programme-reported scales. We aim to increase percentage of programmes with PFPs reporting active QI work within their programme, while maintaining satisfaction in PFP-clinician relationships.Methods Conducted in the Cystic Fibrosis Learning Network (CFLN), an LHN comprising over 30 cystic fibrosis (CF) programmes, people with CF, caregivers and clinicians cocreated interventions in readiness awareness, inclusive PFP recruitment, onboarding process, partnership development and leadership opportunities. Interventions were adapted by CFLN programmes and summarised in a change package for existing programmes and the orientation of new ones. We collected monthly assessments for PFP and programme perceptions of coproduction and PFP self-rated competency of QI skills and satisfaction with programme QI efforts. We used control charts to analyse coproduction scales and run charts for PFP self-ratings.Results Between 2018 and 2022, the CFLN expanded to 34 programmes with 52% having ≥1 PFP reporting active QI participation. Clinicians from 76% of programmes reported PFPs were actively participating or leading QI efforts. PFPs reported increased QI skills competency (17%–32%) and consistently high satisfaction and feeling valued in their work.Conclusions Implementing system-level programmatic strategies to engage and sustain partnerships between clinicians and patients and families with CF improved perceptions of coproduction to conduct QI work. Key adaptable strategies for programmes included onboarding and QI training, supporting multiple PFPs simultaneously and developing financial recognition processes. Interventions may be applicable in other health conditions beyond CF seeking to foster the practice of coproduction.
- Published
- 2024
- Full Text
- View/download PDF
29. Low SARS-CoV-2 transmission in elementary schools - Salt Lake County, Utah, December 3, 2020-January 31, 2021
- Author
-
Bobbi Bryant, Erin L Young, Mary Hill, Keith Waters, Nathaniel M. Lewis, Alison T. Milne, Daniel C. Ehlman, Adam L. Hersh, Kelly F. Oakeson, Victoria T Chu, Hannah L Kirking, Elizabeth Garza, Jacqueline E. Tate, Yoshinori Nakazawa, Snigdha Vallabhaneni, Noah G. Schwartz, Winston E. Abara, Brandi Freeman, Olivia Almendares, Angela Dunn, Dustin W Currie, Karen Wu, Amanda R Smith, Catherine Espinosa, Rebecca B. Hershow, Ilene Risk, Brian Orleans, and Spencer Lloyd
- Subjects
Adult ,Male ,medicine.medical_specialty ,Health (social science) ,Epidemiology ,Health, Toxicology and Mutagenesis ,Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) ,education ,Physical Distancing ,Salt lake ,law.invention ,03 medical and health sciences ,0302 clinical medicine ,Health Information Management ,law ,030225 pediatrics ,Utah ,Medicine ,Humans ,030212 general & internal medicine ,Transmission risks and rates ,Child ,Schools ,business.industry ,SARS-CoV-2 ,Public health ,Incidence (epidemiology) ,Masks ,COVID-19 ,General Medicine ,Middle Aged ,Transmission (mechanics) ,COVID-19 Nucleic Acid Testing ,Child, Preschool ,Female ,Contact Tracing ,Erratum ,business ,Contact tracing ,Demography - Abstract
School closures affected more than 55 million students across the United States when implemented as a strategy to prevent the transmission of SARS-CoV-2, the virus that causes COVID-19 (1). Reopening schools requires balancing the risks for SARS-CoV-2 infection to students and staff members against the benefits of in-person learning (2). During December 3, 2020-January 31, 2021, CDC investigated SARS-CoV-2 transmission in 20 elementary schools (kindergarten through grade 6) that had reopened in Salt Lake County, Utah. The 7-day cumulative number of new COVID-19 cases in Salt Lake County during this time ranged from 290 to 670 cases per 100,000 persons.† Susceptible§ school contacts¶ (students and staff members exposed to SARS-CoV-2 in school) of 51 index patients** (40 students and 11 staff members) were offered SARS-CoV-2 reverse transcription-polymerase chain reaction (RT-PCR) testing. Among 1,041 susceptible school contacts, 735 (70.6%) were tested, and five of 12 cases identified were classified as school-associated; the secondary attack rate among tested susceptible school contacts was 0.7%. Mask use among students was high (86%), and the median distance between students' seats in classrooms was 3 ft. Despite high community incidence and an inability to maintain ≥6 ft of distance between students at all times, SARS-CoV-2 transmission was low in these elementary schools. The results from this investigation add to the increasing evidence that in-person learning can be achieved with minimal SARS-CoV-2 transmission risk when multiple measures to prevent transmission are implemented (3,4).
- Published
- 2021
30. Artificial intelligence accurately identifies total hip arthroplasty implants: a tool for revision surgery
- Author
-
Robert R Burnham, Nicholas M. Brown, Cameron J. Killen, Fahad Sarvari, Michael P. Murphy, and Karen Wu
- Subjects
Reoperation ,medicine.medical_specialty ,Arthroplasty, Replacement, Hip ,Convolutional neural network ,03 medical and health sciences ,0302 clinical medicine ,Artificial Intelligence ,medicine ,Humans ,Orthopedics and Sports Medicine ,030222 orthopedics ,Preoperative planning ,Artificial neural network ,Revision arthroplasty ,business.industry ,Deep learning ,030206 dentistry ,Surgery ,Radiography ,Identification (information) ,Artificial intelligence ,Implant ,business ,Algorithms ,Total hip arthroplasty - Abstract
Background: A critical part in preoperative planning for revision arthroplasty surgery involves the identification of the failed implant. Using a predictive artificial neural network (ANN) model, the objectives of this study were: (1) to develop a machine-learning algorithm using operative big data to identify an implant from a radiograph; and (2) to compare algorithms that optimise accuracy in a timely fashion. Methods: Using 2116 postoperative anteroposterior (AP) hip radiographs of total hip arthroplasties from 2002 to 2019, 10 artificial neural networks were modeled and trained to classify the radiograph according to the femoral stem implanted. Stem brand and model was confirmed with 1594 operative reports. Model performance was determined by classification accuracy toward a random 706 AP hip radiographs, and again on a consecutive series of 324 radiographs prospectively collected over 2019. Results: The Dense-Net 201 architecture outperformed all others with 100.00% accuracy in training data, 95.15% accuracy on validation data, and 91.16% accuracy in the unique prospective series of patients. This outperformed all other models on the validation ( p Conclusions: Neural networks offer a useful adjunct to the surgeon in preoperative identification of the prior implant.
- Published
- 2021
31. Use of the Behavior Assessment Tool in 18 Pilot Residency Programs
- Author
-
Matthew D. Beal, Michelle S. Caird, Stuart T Guthrie, Ann E. Van Heest, Terrance D. Peabody, J. Lawrence Marsh, Michael S. Bednar, John J. Harrast, April D. Armstrong, Matthew D. Karam, Julie Agel, Joshua C. Patt, Karen Wu, David F. Martin, James E. Carpenter, Paul J. Juliano, and Dawn M. LaPorte
- Subjects
medicine.medical_specialty ,Academic year ,Professional behavior ,MEDLINE ,A domain ,Evidence-based medicine ,lcsh:RD701-811 ,lcsh:Orthopedic surgery ,Family medicine ,Orthopedic surgery ,medicine ,Orthopedics and Sports Medicine ,Surgery ,AOA Critical Issues in Education ,Level ii ,Psychology - Abstract
Background:. The purpose of this study was to determine the feasibility and evaluate the effectiveness of the American Board of Orthopaedic Surgery Behavior Tool (ABOSBT) for measuring professionalism. Methods:. Through collaboration between the American Board of Orthopaedic Surgery and American Orthopaedic Association's Council of Residency Directors, 18 residency programs piloted the use of the ABOSBT. Residents requested assessments from faculty at the end of their clinical rotations, and a 360° request was performed near the end of the academic year. Program Directors (PDs) rated individual resident professionalism (based on historical observation) at the outset of the study, for comparison to the ABOSBT results. Results:. Nine thousand eight hundred ninety-two evaluations were completed using the ABOSBT for 449 different residents by 1,012 evaluators. 97.6% of all evaluations were scored level 4 or 5 (high levels of professional behavior) across all of the 5 domains. In total, 2.4% of all evaluations scored level 3 or below reflecting poorer performance. Of 431 residents, the ABOSBT identified 26 of 32 residents who were low performers (2 or more < level 3 scores in a domain) and who also scored “below expectations” by the PD at the start of the pilot project (81% sensitivity and 57% specificity), including 13 of these residents scoring poorly in all 5 domains. Evaluators found the ABOSBT was easy to use (96%) and that it was an effective tool to assess resident professional behavior (81%). Conclusions:. The ABOSBT was able to identify 2.4% low score evaluations (
- Published
- 2020
32. Spinach splice sensor: a cell-based drug discovery platform for splicing-related diseases
- Author
-
Karen Wu
- Published
- 2020
- Full Text
- View/download PDF
33. Characterising acetabular component orientation with pelvic motion during total hip arthroplasty
- Author
-
Steven J Ralles, Robert M. Havey, Cameron J. Killen, Avinash G. Patwardhan, Michael P. Murphy, Saeed Khayatzadeh, Nicholas M. Brown, and Karen Wu
- Subjects
Orthodontics ,business.industry ,Arthroplasty, Replacement, Hip ,Motion (geometry) ,Acetabulum ,Pelvis ,Position (obstetrics) ,Acetabular component ,Orientation (geometry) ,Medicine ,Humans ,Orthopedics and Sports Medicine ,Surgery ,Hip Prosthesis ,Dislocation ,business ,Tomography, X-Ray Computed ,Total hip arthroplasty - Abstract
Introduction: Suboptimal acetabular component position can result in impingement, dislocation, and accelerated wear. Intraoperative pelvic motion has led to surgeon error and acetabular cup malposition. This study characterises the relationship between pelvic rotation and postoperative acetabular cup orientation. Methods: A device was constructed to allow cadaveric pelvis rotation along three axes about an acetabular cup in fixed orientation. The acetabular cup was fixed in space at 40° of radiographic inclination and 15° of anteversion relative to the anterior pelvic plane to represent consistent surgeon intraoperative placement. Active marker clusters were fixed to surgical equipment while the cadaveric pelvis was cemented with passive reflective markers, both identified with the Optotrak Certus motion capture system. The reamed cadaveric pelvis was rotated along three axes from –45° to 45° of roll, –30° to 30° of tilt, and –35° to 35° of pitch. The change in component inclination and anteversion was recorded at each 5° interval. Using computed tomography 3D reconstruction, the experimental setup was duplicated computationally to assess against a greater range of pelvis and implant sizes. Results: Radiographic anteversion and inclination showed a non-linear relationship dependent on pelvic roll, tilt, and pitch. Radiographic anteversion changed –0.59°, 0.76° and 0.01° while radiographic inclination changed 0.23°, 0.18° and 1.00° for every 1° of pelvic roll, tilt and pitch, respectively. Computationally, anteversion changed –0.61°, 0.75° and 0.00° while inclination changed 0.22°, 0.19° and 1.00° for every 1° of pelvic roll, tilt and pitch, respectively. These results were independent of cup and pelvis size. Conclusions: Intraoperative pelvic motion can significantly affect final cup position, and this should be accounted for when placing acetabular components during total hip arthroplasty. Based on this study, intraoperative adjustment of the acetabular component position based on pelvis motion may be implemented to improve postoperative component position.
- Published
- 2020
34. The Understanding and Experiences of Living with Dementia in Chinese New Zealanders
- Author
-
Gary Cheung, April Yuehan Su, Karen Wu, Blake Yue, Susan Yates, Adrian Martinez Ruiz, Rita Krishnamurthi, and Sarah Cullum
- Subjects
China ,Chinese ,dementia ,health literacy ,lived experience ,coping ,Health, Toxicology and Mutagenesis ,Racial Groups ,Public Health, Environmental and Occupational Health ,Caregivers ,mental disorders ,Humans ,Medicine ,New Zealand - Abstract
Little is known about the lived experience of dementia in the New Zealand Chinese community. This study aims to explore the understanding and experiences of living with dementia in Chinese New Zealanders. Participants were recruited from a memory service and a community dementia day programme. In-depth interviews were conducted by bilingual and bicultural researchers. The recorded interviews were transcribed and thematically analysed. Sixteen people living with dementia and family carers participated in this study. The first theme revealed the lack of understanding of dementia prior to diagnosis, the commonly used term of “brain shrinkage” and that dementia is associated with getting older. The second theme covered the symptoms experienced by people with dementia and how family carers found anhedonia and apathy particularly concerning. The third theme highlighted the tension between cultural obligation and carer stress. The fourth theme is about the stigma attached to dementia. Our results provide some insight into ways to improve dementia care for Chinese New Zealanders, including targeted psychoeducation in the Chinese community to improve awareness and to reduce stigma, access to person-centred interventions, and learning about strategies for healthy ageing to live well with dementia, and emotional support and psychoeducation for family carers to reduce carer stress.
- Published
- 2022
- Full Text
- View/download PDF
35. A Rosier Reality: Incongruency in Stated and Revealed Ingroup Preferences among Young Asian American Speed Daters
- Author
-
Karen Wu, Chuansheng Chen, and Ellen Greenberger
- Subjects
Social Psychology ,Speed dating ,Asian americans ,05 social sciences ,050109 social psychology ,0501 psychology and cognitive sciences ,Interpersonal communication ,Psychology ,Ingroups and outgroups ,Social psychology ,050105 experimental psychology - Abstract
Several studies have identified inconsistencies between “stated” interpersonal attitudes and those “revealed” after an interaction. The authors used the speed-dating paradigm to examine stated and revealed attitudes in ingroup preferences among Asian American subgroups (Chinese, Korean, Vietnamese, and Filipino Americans). Young single Asian Americans ( n = 198) reported preferences for dating different ethnicities and went on speed dates, after which they could offer second dates to their partners. As expected, all four ethnic subgroups showed clear ingroup biases in stated preferences. Ingroup bias in revealed preferences (measured through date offers and ratings of partners’ mate desirability), however, were minimal. At the individual level, stated ingroup preferences did not significantly predict revealed ingroup preferences. In summary, among young Asian Americans, ingroup preferences may not hold in an interactive scenario. The findings suggest that in the presence of personal cues provided through a brief interaction, people may be less prone to make judgments on the basis of ethnicity, even when consequences extend beyond the laboratory. Furthermore, mechanisms for selecting a partner may differ in “hot” (affective) versus “cold” (cognitive) states.
- Published
- 2018
- Full Text
- View/download PDF
36. Nice guys and gals can finish first: Personality and speed-dating success among Asian Americans
- Author
-
Chuansheng Chen, Karen Wu, and Ellen Greenberger
- Subjects
Sociology and Political Science ,Social Psychology ,Speed dating ,Communication ,media_common.quotation_subject ,05 social sciences ,Self-esteem ,Nice ,050109 social psychology ,Stereotype ,050105 experimental psychology ,Developmental and Educational Psychology ,Narcissism ,medicine ,Nice guy ,Personality ,0501 psychology and cognitive sciences ,Western culture ,medicine.symptom ,Psychology ,Social psychology ,computer ,media_common ,computer.programming_language - Abstract
In Western culture, both pop theory and recent behavioral research support the “nice guy stereotype,” suggesting that communal qualities that emphasize caring for others may be unattractive in men....
- Published
- 2018
- Full Text
- View/download PDF
37. More than skin deep: Major histocompatibility complex (MHC)-based attraction among Asian American speed-daters
- Author
-
Chuansheng Chen, Ellen Greenberger, Robert K. Moyzis, Zhaoxia Yu, Karen Wu, and Michelle M. Nuño
- Subjects
0301 basic medicine ,Attractiveness ,media_common.quotation_subject ,Experimental and Cognitive Psychology ,Single-nucleotide polymorphism ,Human leukocyte antigen ,Biology ,Major histocompatibility complex ,Attraction ,03 medical and health sciences ,030104 developmental biology ,Arts and Humanities (miscellaneous) ,Evolutionary biology ,biology.protein ,Personality ,SNP ,Ecology, Evolution, Behavior and Systematics ,Behavioural genetics ,media_common - Abstract
What might explain our instinctual attraction to certain individuals, aside from visible factors such as appearance? We examined possible biologically-driven selection for immunology genes, specifically preferences for Major Histocompatibility Complex (MHC)-dissimilarity, through the ecologically-valid method of speed-dating. Two-hundred-and-sixty-two single Asian Americans went on speed-dates ( N observations = 2215) with participants of the other sex, making second date offers and rating each other on measures of mate desirability, facial attractiveness, and body scent attractiveness. Using a single nucleotide polymorphism (SNP) analysis, women, but not men, showed preferences for speed-dating partners based on MHC-complementarity. The direction of findings varied by single nucleotide polymorphism (SNP), such that SNPs closer to the major HLA (Human Leukocyte Antigen) genes supported dissimilarity preferences, whereas those farther away supported similarity preferences. The relative effects of MHC-based measures in comparison to an array of behavioral predictors were examined via random forests. Results indicated that for both men and women, the importance of MHC-based indices was comparable to that of a partner's self-reported personality attributes in predicting second date offers.
- Published
- 2018
- Full Text
- View/download PDF
38. Discriminatory questions asked during residency programme interviews: perspective from both interviewers and applicants
- Author
-
Elizabeth Harkin, Lukas M. Nystrom, Tomas Liskutin, Adam Schiff, Michael P. Murphy, and Karen Wu
- Subjects
Adult ,Male ,Medical education ,Matching (statistics) ,business.industry ,Perspective (graphical) ,Internship and Residency ,Differential (mechanical device) ,General Medicine ,United States ,Compliance (psychology) ,Interviews as Topic ,03 medical and health sciences ,0302 clinical medicine ,Education, Medical, Graduate ,General Surgery ,Surveys and Questionnaires ,Medicine ,Humans ,Female ,030212 general & internal medicine ,business ,Personnel Selection ,030217 neurology & neurosurgery - Abstract
Background The National Resident Matching Program (NRMP) policy requires interview officials to refrain from asking illegal or coercive questions that may introduce discrimination; however, compliance is insufficient. Method An Institutional Review Board-approved 12 question survey was distributed to 130 allopathic medical schools with 551 responses from 18 187 students applying in the 2015–2016 residency match. In addition, a 16-question survey was distributed through residency coordinators to residency programme interviewers with 481 responses from 21 of 22 residency specialities. Results Discriminatory topics were frequently discussed across all specialities. Surgical interviews were significantly more likely to discuss age (relative risk (RR) 2.0, p Conclusions In modern recruitment where differential attainment is of interest, the presence of such explicit discrimination is worrisome. Formal interview training might reduce discrimination, but more active overnight is needed and a zero-tolerance approach to overt discrimination should be the ambition.
- Published
- 2019
39. Protocol for serious fall injury adjudication in the Strategies to Reduce Injuries and Develop Confidence in Elders (STRIDE) study
- Author
-
Julie Weldon, Bridget M. Mignosa, Jocelyn Wiggins, Scott Margolis, Maureen Fagan, Molly Lukas, Heather G. Allore, Obafemi Okuwobi, David Buchner, Pamela W. Duncan, Abby C. King, Jocelyn Nunez, Lawrence Garber, Jeffrey Reist, Albert W. Wu, Sajida Saeed Chaudry, Neil B. Alexander, Cindy Stowe, Kevin P. High, Rosaly Correa-de-Araujo, Haseena Rajeevan, Fred C. Ko, Nancy K. Latham, Katy Araujo, Anita Leveke, Luann Bianco, Crysta Collins, Rixin Wang, Ariela R. Orkaby, Christian Espino, Carol Gordon, Linda V. Nyquist, Lori Goehring, Rosanne M. Leipzig, La Toya Edwards, Cathy Foskett, Deborah Matza, Roxana Hirst, Mukaila Raji, Robert B. Wallace, Scott Feeser, Mary Anne Sterling, Christine Moore, David B. Reuben, Mara Abella, Michael Albert, Geraldine Hawthorne-Jones, Steven B. Clauser, Susan L. Greenspan, Bimal Ashar, Brian Funaro, Patricia C. Dykes, Bernard Birnbaum, Evan C. Hadley, Siobhan K McMahon, Denise Esserman, Erich J. Greene, Amy Shelton, Jonathan F. Bean, Thomas R. Prohaska, Joanne M. McGloin, Marcel Salive, Bonita Lynn Beattie, Sabina Rubeck, Deborah West, Ravishankar Ramaswamy, Peggy Preusse, Thomas G. Travison, Mary Anne Ferchak, Azraa Amroze, Kenneth Rando, Martha B. Carnie, Susan S. Ellenberg, Vivian Chavez, Cynthia J. Brown, Alice Lee, Patti L. Ephraim, Charles Lu, Richard Eder, Amy Larson, Terry Fulmer, Rosario Garcia, Alejandra Salazar, Janelle Howe, Laurence Z. Rubenstein, Peter Peduzzi, Yan Chen, Samuel Ho, Erica Chopskie, Sui Tang, Thomas W. Storer, Teresita Pennestri, Charles Keller, Sergei Romashkan, Taylor Christiansen, Amrish Joseph, Eleni A. Skokos, Lea Harvin, Catherine Hanson, Tiffany Campbell, Liliya Katsovich, Joseph Bianco, Stephen C. Waring, Shalender Bhasin, Kimberly Larsen, James Goodwin, Thomas M. Gill, Angela Shanahan, Allison Richards, David A. Ganz, Anne McDonald, Karen Burek, Jerry H. Gurwitz, Leo Sherman, Dorothy I. Baker, Madeline Rigatti, Albert L. Siu, Nancy Gallagher, Hilary Stenvig, Margaret Hoberg, Joseph Madia, Jeremy N. Rich, Barbara Foster, Michael Miller, Nancy P. Lorenze, Rina Castro, Katy L. B. Araujo, Carri Casteel, Lyndon Joseph, Tara Scheck, Todd M. Manini, Laurence Friedman, Karen Wu, Laura Frain, Jay Magaziner, Yvette Wells, Allise Taran, Eloisa Martinez, Jeremy D. Walston, Tina Ledesma, James Dziura, Margaret Doyle, Naaz Hussain, Lea N. Harvin, Priscilla K. Gazarian, Brooke Brawley, Charles Boult, Yuri Agrawal, Peter Charpentier, Kety Florgomes, Shehzad Basaria, Elena Volpi, Cynthia L. Stowe, David Nock, and Heather Larsen
- Subjects
Physical Injury - Accidents and Adverse Effects ,Clinical Trials and Supportive Activities ,Poison control ,Suicide prevention ,Occupational safety and health ,Study Protocol ,03 medical and health sciences ,STRIDE Investigators ,0302 clinical medicine ,Clinical Research ,030225 pediatrics ,Injury prevention ,medicine ,030212 general & internal medicine ,Adjudication ,Injuries ,business.industry ,lcsh:Public aspects of medicine ,Medical record ,Head injury ,lcsh:Medical emergencies. Critical care. Intensive care. First aid ,lcsh:RA1-1270 ,Injuries and accidents ,lcsh:RC86-88.9 ,General Medicine ,Health Services ,medicine.disease ,3. Good health ,Good Health and Well Being ,Telephone interview ,Public Health and Health Services ,Falls ,Patient Safety ,Medical emergency ,business - Abstract
Background This paper describes a protocol for determining the incidence of serious fall injuries for Strategies to Reduce Injuries and Develop Confidence in Elders (STRIDE), a large, multicenter pragmatic clinical trial with limited resources for event adjudication. We describe how administrative data (from participating health systems and Medicare claims) can be used to confirm participant-reported events, with more time- and resource-intensive full-text medical record data used only on an “as-needed” basis. Methods STRIDE is a pragmatic cluster-randomized controlled trial involving 5451 participants age ≥ 70 and at increased risk for falls, served by 86 primary care practices in 10 US health systems. The STRIDE intervention involves a nurse falls care manager who assesses a participant’s underlying risks for falls, suggests interventions using motivational interviewing, and then creates, implements and longitudinally follows up on an individualized care plan with the participant (and caregiver when appropriate), in partnership with the participant’s primary care provider. STRIDE’s primary outcome is serious fall injuries, defined as a fall resulting in: (1) medical attention billable according to Medicare guidelines with a) fracture (excluding isolated thoracic vertebral and/or lumbar vertebral fracture), b) joint dislocation, or c) cut requiring closure; OR (2) overnight hospitalization with a) head injury, b) sprain or strain, c) bruising or swelling, or d) other injury determined to be “serious” (i.e., burn, rhabdomyolysis, or internal injury). Two sources of data are required to confirm a serious fall injury. The primary data source is the participant’s self-report of a fall leading to medical attention, identified during telephone interview every 4 months, with the confirmatory source being (1) administrative data capturing encounters at the participating health systems or Medicare claims and/or (2) the full text of medical records requested only as needed. Discussion Adjudication is ongoing, with over 1000 potentially qualifying events adjudicated to date. Administrative data can be successfully used for adjudication, as part of a hybrid approach that retrieves full-text medical records only when needed. With the continued refinement and availability of administrative data sources, future studies may be able to use administrative data completely in lieu of medical record review to maximize the quality of adjudication with finite resources. Trial registration ClinicalTrials.gov (NCT02475850). Electronic supplementary material The online version of this article (10.1186/s40621-019-0190-2) contains supplementary material, which is available to authorized users.
- Published
- 2019
- Full Text
- View/download PDF
40. Complications of total joint arthroplasty in solid organ transplant patients versus a large control group
- Author
-
Steven Ralles, Nicholas M. Brown, William Adams, Karen Wu, and Ellen Kroin
- Subjects
030222 orthopedics ,medicine.medical_specialty ,business.industry ,Joint replacement ,Mortality rate ,medicine.medical_treatment ,Incidence (epidemiology) ,Knee replacement ,medicine.disease ,03 medical and health sciences ,0302 clinical medicine ,Primary Hip Arthroplasty ,Internal medicine ,Diabetes mellitus ,Cohort ,Medicine ,Orthopedics and Sports Medicine ,030212 general & internal medicine ,business ,Solid organ transplantation ,Complication - Abstract
Background Solid organ transplant patients are theoretically at increased risk for complications after total joint replacement due to immunosuppressive medication regimens and multiple medical co-morbidities. There are a number of studies that report on outcomes of total joint arthroplasty (TJA) following solid organ transplant, however, the results are heterogeneous. This study evaluated the outcomes of TJA in solid organ transplant patients as compared to non-organ transplant controls at one academic medical center. Methods This study was a single institution retrospective review of a consecutive series of patients who underwent joint replacement following solid organ transplant as compared to a control cohort over a 10-year period. Univariable and multivariable generalized linear mixed effects models were used to compare the odds of readmission, infection, mortality, and being discharged home between transplanted (cases) and non-transplanted (control) patients. Results Transplant and non-transplant cohorts had similar BMI, although transplant patients were younger (61 versus 65 years) and had a higher incidence of Diabetes (55% vs. 16%). On multivariable analysis, there was no difference in the odds of re-admission or rate of infection, but there was an increased risk of death and admission to a rehab facility in the transplant cohort. Conclusion Overall, this study demonstrates that solid organ transplant alone does not increase the risk of peri-operative complications in patients who underwent hip and knee replacement. However, it should be expected that these patients have a higher mortality rate and that many of them will need to be discharged to a post-acute care facility.
- Published
- 2019
41. Steady-state and lifetime-resolved fluorescence-detected circular dichroism using a modified phase-modulation spectrofluorometer
- Author
-
Karen Wu, Lei Geng, Joseph, Melissa J., and McGown, Linda B.
- Subjects
Circular dichroism -- Research ,Fluorimetry -- Analysis ,Fluorescence -- Analysis ,Chemistry - Abstract
This paper describes a new instrumental approach to fluorescence-detected circular dichroism (FDCD) that also allows unprecedented resolution of the circular dichroism of each component in mixtures through a new technique, lifetime-resolved fluorescence-detected circular dichroism (LRFDCD). Both FDCD and LRFDCD are performed on a commercial phase-modulation spectrofluorometer that is modified to produce right-handed and left-handed circularly polarized exciting light. These instrumental modifications are described, including a discussion of the criteria for selection of the Babinet-Soleil compensator as the polarization device. The accuracy and precision of the FDCD measurements, including their dependence on instrumental parameters and the fluorescence and CD characteristics of the sample, were studied using several chiral and achiral compounds. Detection limits for FDCD were determined for two of the chiral compounds. Accurate recovery of lifetimes from fluorescence signals that are excited with circularly polarized light was demonstrated, and resolution of the FDCD signals of individual components in two-component mixtures by LRFDCD was achieved. The FDCD signals recovered by LRFDCD for the individual components in the mixtures showed good agreement with values obtained by steady-state FDCD measurements of solutions of the individual components.
- Published
- 1993
42. Structure-mediated electrochemical performance of SnS 2 anode for Li-ion batteries
- Author
-
Jeng Kuei Chang, Karen Wu, Chuan-Ming Tseng, Tai Chou Lee, and Chia Jung Wu
- Subjects
Materials science ,Ethanol ,General Chemical Engineering ,Nanotechnology ,02 engineering and technology ,General Chemistry ,010402 general chemistry ,021001 nanoscience & nanotechnology ,Microstructure ,Electrochemistry ,01 natural sciences ,0104 chemical sciences ,Ion ,Anode ,chemistry.chemical_compound ,chemistry ,Chemical engineering ,0210 nano-technology ,Porosity ,Current density ,Ethylene glycol - Abstract
In this study, SnS2 powders with various surface morphologies are prepared using a facile solvothermal route with three different solvents. The powders synthesized in ethylene glycol and deionized water exhibit aggregates composed of nanoplates, whereas those synthesized in ethanol show flower-like microspheres (diameter: 1–2 µm) composed of nanosheets (thickness: 60–70 nm). The hierarchical flower-like microstructures can alleviate the volume change during charge/discharge cycles due to their porous nature. In addition, SnS2 synthesized at a lower temperature (100 °C) has nanoplates with a lower thickness, improving electrochemical performance. At a constant current density of 300 mA g−1, the microflowers exhibit a reversible capacity of 460 mAh g−1 after 100 cycles, a retention of 84%. More importantly, at a higher current density of 5000 mA g−1, a reversible capacity of 285 mAh g−1 is obtained. This study demonstrates that SnS2 synthesized using suitable processing design strategies can be used as an efficient active material for lithium-ion batteries.
- Published
- 2016
- Full Text
- View/download PDF
43. Gender Interacts with Opioid Receptor Polymorphism A118G and Serotonin Receptor Polymorphism −1438 A/G on Speed-Dating Success
- Author
-
Ellen Greenberger, Robert K. Moyzis, Zhaoxia Yu, Chuansheng Chen, and Karen Wu
- Subjects
Adult ,Male ,0301 basic medicine ,Sociology and Political Science ,rs6311 ,medicine.drug_class ,Sexual Behavior ,Receptors, Opioid, mu ,Behavioral neuroscience ,Serotonergic ,03 medical and health sciences ,Interpersonal relationship ,Sex Factors ,0302 clinical medicine ,Arts and Humanities (miscellaneous) ,Opioid receptor ,Genotype ,medicine ,Humans ,Interpersonal Relations ,Receptor, Serotonin, 5-HT2A ,Ecology, Evolution, Behavior and Systematics ,Behavioural genetics ,Genetics ,Polymorphism, Genetic ,Asian ,030104 developmental biology ,Mate choice ,Anthropology ,Female ,Psychology ,030217 neurology & neurosurgery ,Social Sciences (miscellaneous) - Abstract
We examined an understudied but potentially important source of romantic attraction-genetics-using a speed-dating paradigm. The mu opioid receptor (OPRM1) polymorphism A118G (rs1799971) and the serotonin receptor (HTR2A) polymorphism -1438 A/G (rs6311) were studied because they have been implicated in social affiliation. Guided by the social role theory of mate selection and prior genetic evidence, we examined these polymorphisms' gender-specific associations with speed-dating success (i.e., date offers, mate desirability). A total of 262 single Asian Americans went on speed-dates with members of the opposite gender and completed interaction questionnaires about their partners. Consistent with our prediction, significant gender-by-genotype interactions were found for speed-dating success. Specifically, the minor variant of A118G (G-allele), which has been linked to submissiveness/social sensitivity, predicted greater speed-dating success for women, whereas the minor variant of -1438 A/G (G-allele), which has been linked to leadership/social dominance, predicted greater speed-dating success for men. For both polymorphisms, reverse "dampening" effects of minor variants were found for opposite-gender counterparts. These results support previous research on the importance of the opioid and serotonergic systems in social affiliation, indicating that their influence extends to dating success, with opposite, yet gender-norm consistent, effects for men and women.
- Published
- 2016
- Full Text
- View/download PDF
44. The Economic Burden of Residency Interviews on Applicants
- Author
-
Harold A, Fogel, Tomas E, Liskutin, Karen, Wu, Lukas, Nystrom, Brendan, Martin, and Adam, Schiff
- Subjects
Interviews as Topic ,Students, Medical ,Education and General Interests ,Costs and Cost Analysis ,Humans ,Internship and Residency - Abstract
The residency match is increasingly competitive. The interview is an essential component, yet little has been documented about the costs applicants incur during the interview process and it is unclear how they manage these expenses.The purpose of this study was to define the economic burden of residency interviews for United States (U.S.) allopathic students participating in the 2016 Main Residency Match. We hypothesized that the financial burden of residency interviews varies based on specialty and plays a role in the applicant's ability to participate in all desired interviews.A 26 question electronic survey was developed following pilot study of applicants to a single residency program. Following validation, the survey was distributed to administrative officials at all U.S. allopathic medical schools for circulation to senior students. Results were pooled for statistical analysis.We received responses from 759 U.S. allopathic seniors. A single interview most commonly costs $250 - $499. Most applicants incurred substantial interview related costs. Sixtyfour percent of respondents spent at least $2,500, while 13% spent $7,500 or more. Specialty competitiveness was predictive of higher interview costs. Seventy-one percent of respondents borrowed money to fund interview costs, and 41% declined interviews for financial reasons.Senior medical students incur substantial costs to participate in residency interviews, often adding to already burdensome educational debt. We encourage residency programs, especially those in competitive specialty fields, to pursue cost reduction strategies. Additionally, medical schools should provide financial counseling to allow students to anticipate interview costs.
- Published
- 2018
45. Trauma to the Pelvis: Injuries to the Rectum and Genitourinary Organs
- Author
-
Joseph A. Posluszny, Jeffrey Branch, Elizabeth Dray, Robert H. Blackwell, Jessica Hannick, Karen Wu, and Fred A. Luchette
- Subjects
medicine.medical_specialty ,Rehabilitation ,Genitourinary system ,business.industry ,medicine.medical_treatment ,Rectum ,medicine.disease ,Surgery ,body regions ,medicine.anatomical_structure ,Blunt ,Orthopedic surgery ,medicine ,Pelvic fracture ,Orthopedics and Sports Medicine ,business ,Trauma surgery ,Pelvis - Abstract
Pelvic trauma is associated with high mortality rates. Blunt pelvic injuries from high-energy mechanisms are often associated with pelvic fractures and injuries to the rectum and genitourinary (GU) tract. In addition, due to close anatomic proximity, penetrating pelvic trauma can injure the bony pelvis, rectum, and GU tract concomitantly. As a result, the assessment and management of pelvic trauma requires a multifaceted approach involving orthopedics, trauma surgery and urology.
- Published
- 2015
- Full Text
- View/download PDF
46. The sweetness of forbidden fruit
- Author
-
Ellen Greenberger, Chuansheng Chen, and Karen Wu
- Subjects
Attractiveness ,Interpersonal relationship ,Sociology and Political Science ,Social Psychology ,Social exchange theory ,Communication ,Developmental and Educational Psychology ,Romantic partners ,Sweetness ,Psychology ,Social psychology ,Developmental psychology - Abstract
Past research on interracial dating has focused on demographic and adjustment factors while ignoring the traits most valued in romantic partners. We examined whether interracial and intraracial daters differ in the extent to which they possess various desirable attributes. In Study 1, undergraduates estimated their partners’ ratings of them on 27 attributes. A factor analysis yielded attractiveness (e.g., physically attractive), cerebral (e.g., intelligent), relational (e.g., compassionate), and vibrancy (e.g., confident) attributes. Compared with intraracial daters, interracial daters reported that their partners saw them more positively on attractiveness, cerebral, and relational attributes (Study 1), rated their partners more positively on attractiveness and cerebral attributes (Study 2), and were rated by independent coders as more physically attractive (Study 3). Implications are discussed.
- Published
- 2014
- Full Text
- View/download PDF
47. Multiple Anterior Tibial Stress Fractures Complicated by Acute Complete Fracture of the Distal Tibia
- Author
-
Laurie M Lomasney, Richard Burke, Andrew L. Chiang, Terrence C. Demos, and Karen Wu
- Subjects
Male ,Orthodontics ,Stress fractures ,Adolescent ,Fractures, Stress ,business.industry ,Middle Aged ,medicine.disease ,Distal tibia ,Radiography ,Tibial Fractures ,Fractures, Open ,Fracture (geology) ,Humans ,Medicine ,Accidental Falls ,Female ,Orthopedics and Sports Medicine ,Surgery ,business - Abstract
A 61-year-old man presents with an open wound over the tibia after a minor fall.
- Published
- 2014
- Full Text
- View/download PDF
48. Land use and soil characteristics affect soil organisms differently from above-ground assemblages
- Author
-
Victoria J. Burton, Sara Contu, Adriana De Palma, Samantha L. L. Hill, Harald Albrecht, James S. Bone, Daniel Carpenter, Ronald Corstanje, Pallieter De Smedt, Mark Farrell, Helen V. Ford, Lawrence N. Hudson, Kelly Inward, David T. Jones, Agnieszka Kosewska, Nancy F. Lo-Man-Hung, Tibor Magura, Christian Mulder, Maka Murvanidze, Tim Newbold, Jo Smith, Andrew V. Suarez, Sasha Suryometaram, Béla Tóthmérész, Marcio Uehara-Prado, Adam J. Vanbergen, Kris Verheyen, Karen Wuyts, Jörn P. W. Scharlemann, Paul Eggleton, and Andy Purvis
- Subjects
Land-use ,Land-use intensity ,Soil biota ,Soil biodiversity ,Organism abundance ,Mixed-effects models ,Ecology ,QH540-549.5 ,Evolution ,QH359-425 - Abstract
Abstract Background Land-use is a major driver of changes in biodiversity worldwide, but studies have overwhelmingly focused on above-ground taxa: the effects on soil biodiversity are less well known, despite the importance of soil organisms in ecosystem functioning. We modelled data from a global biodiversity database to compare how the abundance of soil-dwelling and above-ground organisms responded to land use and soil properties. Results We found that land use affects overall abundance differently in soil and above-ground assemblages. The abundance of soil organisms was markedly lower in cropland and plantation habitats than in primary vegetation and pasture. Soil properties influenced the abundance of soil biota in ways that differed among land uses, suggesting they shape both abundance and its response to land use. Conclusions Our results caution against assuming models or indicators derived from above-ground data can apply to soil assemblages and highlight the potential value of incorporating soil properties into biodiversity models.
- Published
- 2022
- Full Text
- View/download PDF
49. Occipital artery biopsy: Surgical technique
- Author
-
Mohammed Al-Nejar, MD, Karen Wustenberghs, MD, Benoit Thomas, MD, Carmen Schoonjans, MD, and Roderik Deleersnijder, MD
- Subjects
Biopsy ,Giant cell arteritis ,Occipital artery ,Surgical technique ,Temporal arteritis ,Surgery ,RD1-811 ,Diseases of the circulatory (Cardiovascular) system ,RC666-701 - Abstract
Giant cell arteritis is a systemic inflammatory disorder that primarily affects medium- and large-size arteries. Usually, the temporal artery is involved. In rare cases, the patient experiences symptoms elsewhere, such as in the occipital region. In such cases, biopsy of the occipital artery can be considered. Few studies are available on how to perform such a biopsy. In this case report, we describe the procedure in detail, with a focus on the important anatomic structures. We wish to offer other surgeons a quick reference in the case of a request for a biopsy of the occipital artery.
- Published
- 2023
- Full Text
- View/download PDF
50. The Economic Burden of Orthopedic Surgery Residency Interviews on Applicants
- Author
-
Harold A, Fogel, Elissa S, Finkler, Karen, Wu, Adam P, Schiff, and Lukas M, Nystrom
- Subjects
Interviews as Topic ,Orthopedics ,Education, Medical, Graduate ,Orthopaedic Education ,Costs and Cost Analysis ,Humans ,Internship and Residency - Abstract
The intense competition for orthopedic surgery residency positions influences the interview process. The financial impact on residency applicants is less well understood. The purpose of the present study was to define the economic burden of the orthopedic surgery residency interview process while additionally describing how applicants finance the expense.We distributed surveys to 48 nonrotating applicants at our institution's residency interview days for the 2015 match year. The survey consisted of eleven questions specific to the costs of interviewing for orthopedic surgery residency positions.The survey response rate was 90% (43/48). Applicants applied to a median of 65 orthopedic surgery residency programs (range 21-88) and targeted a median of 15 interviews (range 12-25). The mean cost estimate for a single interview was $450 (range $200-800) and the cost estimate for all interviews was $7,119 (range $2,500-15,000). Applicants spent a mean of $344 (range $0-750) traveling to our interview. Seventy-two percent borrowed money to finance their interview costs and 28% canceled interviews for financial reasons.The financial cost of interviewing for orthopedic surgery is substantial and a majority of applicants add to their educational debt by taking out loans to finance interviews. Future considerations should be made to minimize these costs for an already financially burdened population.
- Published
- 2016
Catalog
Discovery Service for Jio Institute Digital Library
For full access to our library's resources, please sign in.