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One of the leading challenges in refractive surgery today is the presence of underlying subclinical early-stage keratoconus (KC), which can lead to iatrogenic post laser in situ keratomileusis ectasia. Timely detection of this condition could aid the refractive surgeons in better decision-making. This includes being able to defer refractive surgery in subclinical cases as well as providing treatment for the same in the form of appropriate corneal collagen crosslinking treatments. Corneal topography is considered the gold standard for the diagnosis of corneal ectatic disorders. However, there is a likelihood that topographers are overlooking certain subclinical cases. The corneal epithelium is known to remodel, which may mask underlying stromal irregularities. Imaging and analyzing corneal epithelium and stroma independently will undoubtedly open newer avenues to supplement our understanding of postrefractive surgery outcomes and KC. This review encapsulates the various Optical coherence tomography-based epithelial mapping devices particularly RTVue (Optovue, Fremont, USA) and MS-39 (Costruzione Strumenti Oftalmici, Florence, Italy) in terms of their utility in these conditions. It will help guide the clinician on how including an epithelial mapping in clinical practice can aid in diagnosis, management, and interpretation of outcomes both for refractive surgery as well as KC.

Purpose: Assessment of pupil diameter in various light conditions and the corresponding corneal spherical aberrations in a cohort of Indian eyes with bilateral senile cataracts and the possible use of this data in aberrometric customization of intraocular lenses (IOLs). Methods: In this prospective observational study done at a tertiary eye care centre in India, the selected patients were subjected to measurement of their pupil diameters in scotopic, mesopic, and photopic conditions as well as the corresponding corneal spherical aberrations, using the Sirius Topographer (Costruzione Strumenti Oftalmici, Florence, Italy). Shapiro–Wilk test, Independent t-test, ANOVA with Bonferroni correction on post-hoc testing were used for statistical analysis. Results: 104 eyes of 52 patients were enrolled for the study. The mean age was 53 ± 11.88 years. The mean scotopic, mesopic, and photopic pupil sizes were 4.37 mm (4.11–4.63 mm), 3.92 mm (3.71 mm–4.15 mm), and 3.37 mm (3.18–3.67 mm), respectively. There was a statistically significant difference (P =

Migraine is a multifactorial disorder with complex neuronal and vascular mechanisms that encompasses a wide clinical spectrum of symptoms, including ocular manifestations. Dry eye disease and dysfunction of ocular somatosensory pathways have been implicated in the pathogenesis. The current study investigates the association between a dysfunctional tear film and ocular aberrations with migraine. Sixty eyes of 30 patients with migraine and 60 eyes of 30 controls were studied. Dry eye evaluation included Schirmer’s test, tear film break-up time, corneal esthesiometry and lipid layer analysis using Lipiview® interferometer. Wavefront aberrations were measured using Optical Path Difference before performing the dry eye evaluation. The intraocular light scatter was quantified using the objective scatter index (OSI) of the optical quality analysis system. Measured parameters were compared between the migraine and the control group using independent sample t-test. Statistical analysis was performed using commercial software. A p value of ≤ 0.05 was considered statistically significant. There were 19 females and 11 males in each group. Statistically significant difference was found between the two groups with respect to total aberrations (p = 0.049), higher order aberrations (p = 0.009), coma (p = 0.03), spherical aberrations (p = 0.018), Lipiview interferometric coloric units (p

A 28-year-old woman with bilateral stable keratoconus for 2 years came with a complaint of recent blurring of vision 4 weeks postpartum. Her best-corrected visual acuity had dropped by three lines in the right eye and two lines in the left eye with the same manifest refraction. Corneal topography and Scheimpflug imaging revealed mild progression of the keratoconus, but not enough to explain the drop in visual acuity. However, fundus examination revealed temporal disk pallor in both eyes. Visual field analysis revealed classic bitemporal hemianopia. Subsequently, magnetic resonance imaging (MRI) of brain was performed which revealed a pituitary macroadenoma with pituitary apoplexy that was impinging on the pons. Based on these findings, urgent neurosurgery was performed, and the patient regained her visual acuity and fields 2 weeks later. Neuro-ophthalmologic disorders should always be kept as a differential diagnosis in pregnant and postpartum women. A high index of suspicion from the ophthalmologist can often avert life-threatening problems. Key message Neuro-ophthalmologic disorders can masquerade as a variety of clinical presentations in pregnant and postpartum women. A high index of suspicion from the ophthalmologist can often avert life-threatening problems. How to cite this article Shetty R, D’Souza S, Kankariya VP, Srivastava S, Vasavada V, Wadia K. Neurologic Disorder Masquerading as Postpregnancy Progression of Keratoconus. Int J Kerat Ect Cor Dis 2012;1(3):205-208.

Background Migraine is a multifactorial disorder with complex neuronal and vascular mechanisms that encompasses a wide clinical spectrum of symptoms, including ocular manifestations. Dry eye disease and dysfunction of ocular somatosensory pathways have been implicated in the pathogenesis. The current study investigates the association between a dysfunctional tear film and ocular aberrations with migraine. Methods Sixty eyes of 30 patients with migraine and 60 eyes of 30 controls were studied. Dry eye evaluation included Schirmer’s test, tear film break-up time, corneal esthesiometry and lipid layer analysis using Lipiview® interferometer. Wavefront aberrations were measured using Optical Path Difference before performing the dry eye evaluation. The intraocular light scatter was quantified using the objective scatter index (OSI) of the optical quality analysis system. Measured parameters were compared between the migraine and the control group using independent sample t-test. Statistical analysis was performed using commercial software. A p value of ≤ 0.05 was considered statistically significant. Results There were 19 females and 11 males in each group. Statistically significant difference was found between the two groups with respect to total aberrations (p = 0.049), higher order aberrations (p = 0.009), coma (p = 0.03), spherical aberrations (p = 0.018), Lipiview interferometric coloric units (p

PURPOSE: To intraoperatively determine and compare the characteristics and predictability of LASIK flaps made by the WaveLight FS200 femtosecond laser (Alcon Laboratories Inc) and Hansatome (Bausch & Lomb) microkeratome using a hand-held spectral domain ophthalmic imaging system (Bioptigen Inc). METHODS: Sixty eyes from 30 patients undergoing bilateral LASIK were prospectively evaluated. Patients were divided into two equal groups to undergo flap creation with either 100-μm femtosecond laser flaps (FS flap group) or 120-μm microkeratome flaps (MK flap group). Flap thickness was measured intraoperatively after creation of the flap but prior to lifting using the hand-held probe of the spectral domain imaging system. Geometry of the flap edge and smoothness of the stromal bed after lifting the flap was also evaluated in all cases. RESULTS: Mean difference between planned and achieved flap thickness in the paracentral region was 2.84±3.16 mm for the FS flap group and 11.33±10.27 mm for the MK flap group, whereas in the periphery, it was 5.72±3.26 mm in the FS flap group and 24.67±10.35 mm in the MK flap group. The differences between groups were statistically significant ( P CONCLUSIONS: The WaveLight FS200 femtosecond laser is able to produce planar flaps with a high degree of predictability between the desired and achieved flap thickness. The ability to study the flap characteristics intraoperatively (when flap edema and stromal bed hydration changes have not yet occurred) with the hand-held probe of the Bioptigen imaging system ensures greater accuracy than measurements done postoperatively using other anterior segment optical coherence tomography prototypes.