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406 results on '"Karbasi, Saeed"'

36. Magnetic CoFe2O4 nanoparticles doped with metal ions: A review

Author

Sharifianjazi, Fariborz, Moradi, Mostafa, Parvin, Nader, Nemati, Ali, Jafari Rad, Azadeh, Sheysi, Niloufar, Abouchenari, Aliasghar, Mohammadi, Ali, Karbasi, Saeed, Ahmadi, Zohre, Esmaeilkhanian, Amirhossein, Irani, Mohammad, Pakseresht, Amirhosein, Sahmani, Saeid, and Shahedi Asl, Mehdi

Published
2020
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42. Graphene oxide-encapsulated baghdadite nanocomposite improved physical, mechanical, and biological properties of a vancomycin-loaded PMMA bone cement.

Author

Tavakoli, Mohamadreza, Najafinezhad, Aliakbar, Mirhaj, Marjan, Karbasi, Saeed, Varshosaz, Jaleh, Al-Musawi, Mastafa H., Madaninasab, Pegah, Sharifianjazi, Fariborz, Mehrjoo, Morteza, Salehi, Saeideh, Kazemi, Nafise, and Nasiri-Harchegani, Sepideh

Abstract

Polymethyl methacrylate (PMMA) bone cement is commonly used in orthopedic surgeries to fill the bone defects or fix the prostheses. These cements are usually containing amounts of a nonbioactive radiopacifying agent such as barium sulfate and zirconium dioxide, which does not have a good interface compatibility with PMMA, and the clumps formed from these materials can scratch metal counterfaces. In this work, graphene oxide encapsulated baghdadite (GOBgh) nanoparticles were applied as radiopacifying and bioactive agent in a PMMA bone cement containing 2 wt.% of vancomycin (VAN). The addition of 20 wt.% of GOBgh (GOBgh20) nanoparticles to PMMA powder caused a 33.6% increase in compressive strength and a 70.9% increase in elastic modulus compared to the Simplex® P bone cement, and also enhanced the setting properties, radiopacity, antibacterial activity, and the apatite formation in simulated body fluid. In vitro cell assessments confirmed the increase in adhesion and proliferation of MG-63 cells as well as the osteogenic differentiation of human adipose-derived mesenchymal stem cells on the surface of PMMA-GOBgh20 cement. The chorioallantoic membrane assay revealed the excellent angiogenesis activity of nanocomposite cement samples. In vivo experiments on a rat model also demonstrated the mineralization and bone integration of PMMA-GOBgh20 cement within four weeks. Based on the promising results obtained, PMMA-GOBgh20 bone cement is suggested as an optimal sample for use in orthopedic surgeries. [ABSTRACT FROM AUTHOR]

Published
2024
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43. Corrigendum to “Exploring the evolution of tissue engineering strategies over the past decade: From cell-based strategies to gene-activated matrix” [Alex. Eng. J. 81 (2023) 137–169]

Author

Esmaeili, Yasaman, primary, Bidram, Elham, additional, Bigham, Ashkan, additional, Atari, Mehdi, additional, Azadani, Reyhaneh Nasr, additional, Tavakoli, Mohamadreza, additional, Salehi, Saeideh, additional, Mirhaj, Marjan, additional, Basiri, Arefeh, additional, Mirzavandi, Zahra, additional, Boshtam, Maryam, additional, Rafienia, Mohammad, additional, Kharazi, Anousheh Zargar, additional, Karbasi, Saeed, additional, Shariati, Laleh, additional, and Zarrabi, Ali, additional

Published
2023
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49. PCL/Agarose 3D-printed scaffold for tissue engineering applications: fabrication, characterization, and cellular activities.

Author

Ghaedamini, Sho'leh, Karbasi, Saeed, Hashemibeni, Batool, Honarvar, Ali, and Rabiei, Abbasali

Subjects
*TISSUE scaffolds, *TISSUE engineering, *AGAROSE, *CELL morphology, *SCANNING electron microscopy, *INFRARED spectroscopy
Abstract

Background and purpose: Biomaterials, scaffold manufacturing, and design strategies with acceptable mechanical properties are the most critical challenges facing tissue engineering. Experimental approach: In this study, polycaprolactone (PCL) scaffolds were fabricated through a novel three-dimensional (3D) printing method. The PCL scaffolds were then coated with 2% agarose (Ag) hydrogel. The 3D-printed PCL and PCL/Ag scaffolds were characterized for their mechanical properties, porosity, hydrophilicity, and water absorption. The construction and morphology of the printed scaffolds were evaluated via Fourier-Transform infrared spectroscopy (FTIR) and scanning electron microscopy (SEM). The attachment and proliferation of L929 cells cultured on the scaffolds were investigated through MTT assay on the cell culture study upon the 1st, 3rd, and 7th days. Findings/Results: The incorporation of Ag hydrogel with PCL insignificantly decreased the mechanical strength of the scaffold. The presence of Ag enhanced the hydrophilicity and water absorption of the scaffolds, which could positively influence their cell behavior compared to the PCL scaffolds. Regarding cell morphology, the cells on the PCL scaffolds had a more rounded shape and less cell spreading, representing poor cell attachment and cell-scaffold interaction due to the hydrophobic nature of PCL. Conversely, the cells on the PCL/Ag scaffolds were elongated with a spindle-shaped morphology indicating a positive cell-scaffold interaction. Conclusion and implications: PCL/Ag scaffolds can be considered appropriate for tissue-engineering applications. [ABSTRACT FROM AUTHOR]

Published
2023
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