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3. Fabrication of PLA-Based Nanoneedle Patches Loaded with Transcutol-Modified Chitosan Nanoparticles for the Transdermal Delivery of Levofloxacin.

Author

Samiotaki, Christina, Koumentakou, Ioanna, Christodoulou, Evi, Bikiaris, Nikolaos D., Vlachou, Marilena, Karavas, Evangelos, Tourlouki, Konstantina, Kehagias, Nikolaos, and Barmpalexis, Panagiotis

Subjects
DRUG delivery systems, TRANSDERMAL medication, LACTIC acid, X-ray diffraction, COMPRESSIVE strength, POLYMER blends
Abstract

Current transdermal drug delivery technologies, like patches and ointments, effectively deliver low molecular weight drugs through the skin. However, delivering larger, hydrophilic drugs and macromolecules remains a challenge. In the present study, we developed novel transdermal nanoneedle patches containing levofloxacin-loaded modified chitosan nanoparticles. Chitosan was chemically modified with transcutol in three ratios (1/1, 1/2, 1/3, w/w), and the optimum ratio was used for nanoparticle fabrication via the ionic gelation method. The successful modification was confirmed using ATR-FTIR spectroscopy, while DLS results revealed that only the 1/3 ratio afforded suitably sized particles of 220 nm. After drug encapsulation, the particle size increased to 435 nm, and the final formulations were examined via XRD and an in vitro dissolution test, which suggested that the nanoparticles reach 60% release in a monophasic pattern at 380 h. We then prepared transdermal patches with pyramidal geometry nanoneedles using different poly(lactic acid)/poly(ethylene adipate) (PLA/PEAd) polymer blends of varying ratios, which were characterized in terms of morphology and mechanical compressive strength. The 90/10 blend exhibited the best mechanical properties and was selected for further testing. Ex vivo permeation studies proved that the nanoneedle patches containing drug-loaded nanoparticles achieved the highest levofloxacin permeation (88.1%). [ABSTRACT FROM AUTHOR]

Published
2024
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9. Investigation of Molecular Weight, Polymer Concentration and Process Parameters Factors on the Sustained Release of the Anti-Multiple-Sclerosis Agent Teriflunomide from Poly(ε-caprolactone) Electrospun Nanofibrous Matrices

Author

Bikiaris, Nikolaos D., primary, Koumentakou, Ioanna, additional, Michailidou, Georgia, additional, Kostoglou, Margaritis, additional, Vlachou, Marilena, additional, Barmpalexis, Panagiotis, additional, Karavas, Evangelos, additional, and Papageorgiou, George Z., additional

Published
2022
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12. Poly(Lactic Acid)-Based Microparticles for Drug Delivery Applications: An Overview of Recent Advances

Author

Vlachopoulos, Antonios, primary, Karlioti, Georgia, additional, Balla, Evangelia, additional, Daniilidis, Vasileios, additional, Kalamas, Theocharis, additional, Stefanidou, Myrika, additional, Bikiaris, Nikolaos D., additional, Christodoulou, Evi, additional, Koumentakou, Ioanna, additional, Karavas, Evangelos, additional, and Bikiaris, Dimitrios N., additional

Published
2022
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26. Surface modified multifunctional and stimuli responsive nanoparticles for drug targeting: Current status and uses

Author

Siafaka, Panoraia I., Okur Üstündağ, Neslihan, Karavas, Evangelos, and Bikiaris, Dimitrios N.

Subjects
Toxicity, Multifunctional Nanocarriers, Drug Delivery, Cell Targeting, Stimuli Responsive, Surface Modification
Abstract

WOS: 000385525500067 PubMed ID: 27589733 Nanocarriers, due to their unique features, are of increased interest among researchers working with pharmaceutical formulations. Polymeric nanoparticles and nanocapsules, involving non-toxic biodegradable polymers, liposomes, solid lipid nanoparticles, and inorganic-organic nanomaterials, are among the most used carriers for drugs for a broad spectrum of targeted diseases. In fact, oral, injectable, transdermal-dermal and ocular formulations mainly consist of the aforementioned nanomaterials demonstrating promising characteristics such as long circulation, specific targeting, high drug loading capacity, enhanced intracellular penetration, and so on. Over the last decade, huge advances in the development of novel, safer and less toxic nanocarriers with amended properties have been made. In addition, multifunctional nanocarriers combining chemical substances, vitamins and peptides via coupling chemistry, inorganic particles coated by biocompatible materials seem to play a key role considering that functionalization can enhance characteristics such as biocompatibility, targetability, environmental friendliness, and intracellular penetration while also have limited side effects. This review aims to summarize the state of the art of drug delivery carriers in nanosize, paying attention to their surface functionalization with ligands and other small or polymeric compounds so as to upgrade active and passive targeting, different release patterns as well as cell targeting and stimuli responsibility. Lastly, future aspects and potential uses of nanoparticulated drug systems are outlined.

Published
2016

29. Evaluating the effects of crystallinity in new biocompatible polyester nanocarriers on drug release behavior

Author

Karavelidis,Vassilios, Karavas,Evangelos, Giliopoulos,Dimitrios, Papadimitriou,Sofia, Bikiaris,Dimitrios, Karavelidis,Vassilios, Karavas,Evangelos, Giliopoulos,Dimitrios, Papadimitriou,Sofia, and Bikiaris,Dimitrios

Abstract

Vassilios Karavelidis1,2, Evangelos Karavas2, Dimitrios Giliopoulos1, Sofia Papadimitriou1, Dimitrios Bikiaris11Laboratory of Polymer Chemistry and Technology, Chemistry Department, Aristotle University of Thessaloniki, Thessaloniki, 2Pharmathen SA, Pharmaceutical Industry, Pallini Attikis, Attiki, GreeceAbstract: Four new polyesters based on 1,3-propanediol and different aliphatic dicarboxylic acids were used to prepare ropinirole HCl-loaded nanoparticles. The novelty of this study lies in the use of polyesters with similar melting points but different degrees of crystallinity, varying from 29.8% to 67.5%, as drug nanocarriers. Based on their toxicity to human umbilical vein endothelial cells, these aliphatic polyesters were found to have cytotoxicity similar to that of polylactic acid and so may be considered as prominent drug nanocarriers. Drug encapsulation in polyesters was performed via an emulsification/solvent evaporation method. The mean particle size of drug-loaded nanoparticles was 164–228 nm, and the drug loading content was 16%–23%. Wide angle X-ray diffraction patterns showed that ropinirole HCl existed in an amorphous state within the nanoparticle polymer matrices. Drug release diagrams revealed a burst effect for ropinirole HCl in the first 6 hours, probably due to release of drug located on the nanoparticle surface, followed by slower release. The degree of crystallinity of the host polymer matrix seemed to be an important parameter, because higher drug release rates were observed in polyesters with a low degree of crystallinity.Keywords: biocompatible polyesters, nanoparticles, ropinirole, release, crystallinity

Published
2011

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