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This article, titled "Cover Feature: Highly Electrophilic Intermediates in the Bypass Mechanism of Glutathione Peroxidase: Synthesis, Reactivity, and Structures of Selenocysteine-Derived Cyclic Selenenyl Amides," explores the role of selenocysteine cyclic selenenyl amides in the catalytic cycle of the antioxidant enzyme glutathione peroxidase (GPx). The study reveals that these intermediates, previously overlooked, have dual functionality. They not only prevent the inactivation of GPx but also act as highly electrophilic intermediates in selenoprotein reactions. The researchers compare the roles of these intermediates to a chess king, dynamically adapting to their application. [Extracted from the article]