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7. Biogenic synthesis of silver nanoparticles using Sambucus nigraleaves: elucidation, antimicrobial, antioxidant activities and quantification of phenolics

Author

Karan, Tunay, Erenler, Ramazan, Gonulalan, Zafer, and Kolemen, Ugur

Abstract

Biogenic production of silver nanoparticles (sn-AgNPs) was accomplished by Sambucus nigra. The identification of structures was performed by a wide spectroscopic study. Ultraviolet–visible (UV–Vis) spectroscopic study indicated the maximum absorption of nanoparticles at 480 nm. Scanning electron microscopy (SEM) presented the nanoparticles as spherical shapes. X-ray diffraction (XRD) signals (2θ) at the degrees of 38.20°, 44.40°, 64.61°, 77.61°, and 81.76° corresponded to [111, 020, 202, 131, and 222] facet, respectively, confirming the nanostructure as face-centered cubic structure. The size of the nanoparticles was determined as 28.6 nm and 27.4 nm by SEM and TEM images, respectively. Zeta potential presented the stability of the product (− 51.3 mV). Furthermore, the histogram of dynamic light scattering (DLS) displayed the particle size of the nanostructure as 31.01 nm. HPLC analysis was used to determine the phenolics in S. nigraaerial part quantitatively and chlorogenic acid was the main product (10.76 mg/g extract). sn-AgNPs showed the substantial antioxidant effect as 12.1 ± 0.19 (µg/mL, lC50) and 3.1 ± 0.1 (lC50) for DPPH•and ABTS•+assays, respectively. Antibacterial activity of extract and sn-AgNPs was executed. Both extract and Sn-AgNPs exhibited considerable activity.

Published
2024
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8. SYNTHESIS OF SILVER NANOPARTICLES FROM Camellia sinensis WASTE AND EVALUATION OF THEIR CYTOTOXIC EFFECT.

Author

Erenler, Ramazan, Karan, Tunay, and Bozer, Busra Moran

Abstract

Silver nanoparticle synthesis was achieved using waste tea produced from tea factories and investigated their anticancer activity. The waste material was heated with deionized water at 45°C and then the solution was filtrated. The filtrate was reacted with silver nitrate to yield the silver nanoparticles (AgNPs). The structure of AgNPs was determined by spectroscopic analysis. The cytotoxic effect of extract and AgNPs were performed using the human lung carcinoma cell lines (A549), colon adenocarcinoma cell lines (DLD-1), and mouse fibroblasts (L929) cell lines by MTT assay. In UV-Vis measurement, the maximum absorption was observed at 445 nm. The nanoparticles morphology was established by Transmission electron microscopy (TEM) and particle size was determined as 17.6 nm. The structure of AgNPs was presented as a face-centered cubic structure by X-ray Diffraction (XRD) analysis. The high negative value of zeta potential (-31.3 mV) displayed the stability of the nanostructure. The yield of AgNPs was calculated by elemental analysis as 72.35%. AgNPs exhibited an outstanding effect on A549 and DLD-1 cell lines at 1.0 mg/mL with the lethal effect of 89.3% and 83% respectively. AgNPs synthesized from waste tea may be promising agents for cancer treatment. Since silver nanoparticles synthesized from waste tea revealed excellent cytotoxic effects against various cancer cells. [ABSTRACT FROM AUTHOR]

Published
2023
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12. Stratification strength and light climate explain variation in chlorophyll a at the continental scale in a European multilake survey in a heatwave summer

Author

Donis, Daphne, Mantzouki, Evanthia, McGinnis, Daniel F., Vachon, Dominic, Gallego, Irene, Grossart, Hans-Peter, Domis, Lisette N. de Senerpont, Teurlincx, Sven, Seelen, Laura, Lurling, Miquel, Verstijnen, Yvon, Maliaka, Valentini, Fonvielle, Jeremy, Visser, Petra M., Verspagen, Jolanda, van Herk, Maria, Antoniou, Maria G., Tsiarta, Nikoletta, McCarthy, Valerie, Perello, Victor C., Machado-Vieira, Danielle, de Oliveira, Alinne Gurjao, Maronic, Dubravka Spoljaric, Stevic, Filip, Pfeiffer, Tanja Zuna, Vucelic, Itana Bokan, Zutinic, Petar, Udovic, Marija Gligora, Blaha, Ludek, GeriS, Rodan, Fankova, Marketa, Christoffersen, Kirsten Seestern, Warming, Trine Perlt, Feldmann, Tonu, Laas, Alo, Panksep, Kristel, Tuvikene, Lea, Kangro, Kersti, Koreiviene, Judita, Karosiene, Jurate, Kasperoviciene, Jurate, Savadova-Ratkus, Ksenija, Vitonyte, Irma, Haggqvist, Kerstin, Salmi, Pauliina, Arvola, Lauri, Rothhaupt, Karl, Avagianos, Christos, Kaloudis, Triantafyllos, Gkelis, Spyros, Panou, Manthos, Triantis, Theodoros, Zervou, Sevasti-Kiriaki, Hiskia, Anastasia, Obertegger, Ulrike, Boscaini, Adriano, Flaim, Giovanna, Salmaso, Nico, Cerasino, Leonardo, Haande, Sigrid, Skjelbred, Birger, Grabowska, Magdalena, Karpowicz, Maciej, Chmura, Damian, Nawrocka, Lidia, Kobos, Justyna, Mazur-Marzec, Hanna, Alcaraz-Parraga, Pablo, Wilk-Wozniak, Elzbieta, Krzton, Wojciech, Walusiak, Edward, Gagala-Borowska, Ilona, Mankiewicz-Boczek, Joana, Toporowska, Magdalena, Pawlik-Skowronska, Barbara, Niedzwiecki, Michal, Napiorkowska-Krzebietke, Agnieszka, Dunalska, Julita, Sienska, Justyna, Szymanski, Daniel, Kruk, Marek, Budzynska, Agnieszka, Goldyn, Ryszard, Kozak, Anna, Rosinska, Joanna, Domek, Piotr, Jakubowska-Krepska, Natalia, Kwasizur, Kinga, Messyasz, Beata, Kokocinski, Mikolaj, Madrecka-Witkowska, Beata, Kostrzewska-Szlakowska, Iwona, Frak, Magdalena, Bankowska-Sobczak, Agnieszka, Wasilewicz, Michal, Ochocka, Agnieszka, Pasztaleniec, Agnieszka, Jasser, Iwona, Antao-Geraldes, Ana M., Leira, Manel, Vasconcelos, Vitor, Morais, Joao, Vale, Micaela, Raposeiro, Pedro M., Goncalves, Vitor, Aleksovski, Boris, Krstic, Svetislav, Nemova, Hana, Drastichova, Iveta, Chomova, Lucia, Remec-Rekar, Spela, Elersek, Tina, Hansson, Lars-Anders, Urrutia Cordero, Pablo, Bravo, Andrea Garcia, Buck, Moritz, Colom-Montero, William, Mustonen, Kristiina, Pierson, Don, Yang, Yang, Richardson, Jessica, Edwards, Christine, Cromie, Hannah, Delgado-Martin, Jordi, Garcia, David, Luis Cereijo, Jose, Goma, Joan, Carmen Trapote, Mari, Vegas-Vilarrubia, Teresa, Obrador, Biel, Garcia-Murcia, Ana, Real, Monserrat, Romans, Elvira, Noguero-Ribes, Jordi, Duque, David Parreno, Fernandez-Moran, Elisabeth, Ubeda, Barbara, Galvez, Jose Angel, Catalan, Nuria, Perez-Martinez, Carmen, Ramos-Rodriguez, Eloisa, Cillero-Castro, Carmen, Moreno-Ostos, Enrique, Maria Blanco, Jose, Rodriguez, Valeriano, Juan Montes-Perez, Jorge, Palomino, Roberto L., Rodriguez-Perez, Estela, Hernandez, Armand, Carballeira, Rafael, Camacho, Antonio, Picazo, Antonio, Rochera, Carlos, Santamans, Anna C., Ferriol, Carmen, Romo, Susana, Miguel Soria, Juan, Ozen, Arda, Karan, Tunay, Demir, Nilsun, Beklioglu, Meryem, Filiz, Nur, Levi, Eti, Iskin, Ugur, Bezirci, Gizem, Tavsanoglu, Ulku Nihan, Celik, Kemal, Ozhan, Koray, Karakaya, Nusret, Kocer, Mehmet Ali Turan, Yilmaz, Mete, Maraslioglu, Faruk, Soylu, Elif Neyran, Fakioglu, Ozden, Yagci, Meral Apaydin, Cinar, Sakir, Capkin, Kadir, Yagci, Abdulkadir, Cesur, Mehmet, Bilgin, Fuat, Bulut, Cafer, Uysal, Rahmi, Latife, Koker, Akcaalan, Reyhan, Albay, Meric, Alp, Mehmet Tahir, Ozkan, Korhan, Sevindik, Tugba Ongun, Tunca, Hatice, Onem, Burcin, Paerl, Hans, Carey, Cayelan C., Ibelings, Bastiaan W., Donis, Daphne, Mantzouki, Evanthia, McGinnis, Daniel F., Vachon, Dominic, Gallego, Irene, Grossart, Hans-Peter, Domis, Lisette N. de Senerpont, Teurlincx, Sven, Seelen, Laura, Lurling, Miquel, Verstijnen, Yvon, Maliaka, Valentini, Fonvielle, Jeremy, Visser, Petra M., Verspagen, Jolanda, van Herk, Maria, Antoniou, Maria G., Tsiarta, Nikoletta, McCarthy, Valerie, Perello, Victor C., Machado-Vieira, Danielle, de Oliveira, Alinne Gurjao, Maronic, Dubravka Spoljaric, Stevic, Filip, Pfeiffer, Tanja Zuna, Vucelic, Itana Bokan, Zutinic, Petar, Udovic, Marija Gligora, Blaha, Ludek, GeriS, Rodan, Fankova, Marketa, Christoffersen, Kirsten Seestern, Warming, Trine Perlt, Feldmann, Tonu, Laas, Alo, Panksep, Kristel, Tuvikene, Lea, Kangro, Kersti, Koreiviene, Judita, Karosiene, Jurate, Kasperoviciene, Jurate, Savadova-Ratkus, Ksenija, Vitonyte, Irma, Haggqvist, Kerstin, Salmi, Pauliina, Arvola, Lauri, Rothhaupt, Karl, Avagianos, Christos, Kaloudis, Triantafyllos, Gkelis, Spyros, Panou, Manthos, Triantis, Theodoros, Zervou, Sevasti-Kiriaki, Hiskia, Anastasia, Obertegger, Ulrike, Boscaini, Adriano, Flaim, Giovanna, Salmaso, Nico, Cerasino, Leonardo, Haande, Sigrid, Skjelbred, Birger, Grabowska, Magdalena, Karpowicz, Maciej, Chmura, Damian, Nawrocka, Lidia, Kobos, Justyna, Mazur-Marzec, Hanna, Alcaraz-Parraga, Pablo, Wilk-Wozniak, Elzbieta, Krzton, Wojciech, Walusiak, Edward, Gagala-Borowska, Ilona, Mankiewicz-Boczek, Joana, Toporowska, Magdalena, Pawlik-Skowronska, Barbara, Niedzwiecki, Michal, Napiorkowska-Krzebietke, Agnieszka, Dunalska, Julita, Sienska, Justyna, Szymanski, Daniel, Kruk, Marek, Budzynska, Agnieszka, Goldyn, Ryszard, Kozak, Anna, Rosinska, Joanna, Domek, Piotr, Jakubowska-Krepska, Natalia, Kwasizur, Kinga, Messyasz, Beata, Kokocinski, Mikolaj, Madrecka-Witkowska, Beata, Kostrzewska-Szlakowska, Iwona, Frak, Magdalena, Bankowska-Sobczak, Agnieszka, Wasilewicz, Michal, Ochocka, Agnieszka, Pasztaleniec, Agnieszka, Jasser, Iwona, Antao-Geraldes, Ana M., Leira, Manel, Vasconcelos, Vitor, Morais, Joao, Vale, Micaela, Raposeiro, Pedro M., Goncalves, Vitor, Aleksovski, Boris, Krstic, Svetislav, Nemova, Hana, Drastichova, Iveta, Chomova, Lucia, Remec-Rekar, Spela, Elersek, Tina, Hansson, Lars-Anders, Urrutia Cordero, Pablo, Bravo, Andrea Garcia, Buck, Moritz, Colom-Montero, William, Mustonen, Kristiina, Pierson, Don, Yang, Yang, Richardson, Jessica, Edwards, Christine, Cromie, Hannah, Delgado-Martin, Jordi, Garcia, David, Luis Cereijo, Jose, Goma, Joan, Carmen Trapote, Mari, Vegas-Vilarrubia, Teresa, Obrador, Biel, Garcia-Murcia, Ana, Real, Monserrat, Romans, Elvira, Noguero-Ribes, Jordi, Duque, David Parreno, Fernandez-Moran, Elisabeth, Ubeda, Barbara, Galvez, Jose Angel, Catalan, Nuria, Perez-Martinez, Carmen, Ramos-Rodriguez, Eloisa, Cillero-Castro, Carmen, Moreno-Ostos, Enrique, Maria Blanco, Jose, Rodriguez, Valeriano, Juan Montes-Perez, Jorge, Palomino, Roberto L., Rodriguez-Perez, Estela, Hernandez, Armand, Carballeira, Rafael, Camacho, Antonio, Picazo, Antonio, Rochera, Carlos, Santamans, Anna C., Ferriol, Carmen, Romo, Susana, Miguel Soria, Juan, Ozen, Arda, Karan, Tunay, Demir, Nilsun, Beklioglu, Meryem, Filiz, Nur, Levi, Eti, Iskin, Ugur, Bezirci, Gizem, Tavsanoglu, Ulku Nihan, Celik, Kemal, Ozhan, Koray, Karakaya, Nusret, Kocer, Mehmet Ali Turan, Yilmaz, Mete, Maraslioglu, Faruk, Soylu, Elif Neyran, Fakioglu, Ozden, Yagci, Meral Apaydin, Cinar, Sakir, Capkin, Kadir, Yagci, Abdulkadir, Cesur, Mehmet, Bilgin, Fuat, Bulut, Cafer, Uysal, Rahmi, Latife, Koker, Akcaalan, Reyhan, Albay, Meric, Alp, Mehmet Tahir, Ozkan, Korhan, Sevindik, Tugba Ongun, Tunca, Hatice, Onem, Burcin, Paerl, Hans, Carey, Cayelan C., and Ibelings, Bastiaan W.

Abstract

To determine the drivers of phytoplankton biomass, we collected standardized morphometric, physical, and biological data in 230 lakes across the Mediterranean, Continental, and Boreal climatic zones of the European continent. Multilinear regression models tested on this snapshot of mostly eutrophic lakes (median total phosphorus [TP] = 0.06 and total nitrogen [TN] = 0.7 mg L-1), and its subsets (2 depth types and 3 climatic zones), show that light climate and stratification strength were the most significant explanatory variables for chlorophyll a (Chl a) variance. TN was a significant predictor for phytoplankton biomass for shallow and continental lakes, while TP never appeared as an explanatory variable, suggesting that under high TP, light, which partially controls stratification strength, becomes limiting for phytoplankton development. Mediterranean lakes were the warmest yet most weakly stratified and had significantly less Chl a than Boreal lakes, where the temperature anomaly from the long-term average, during a summer heatwave was the highest (+4 degrees C) and showed a significant, exponential relationship with stratification strength. This European survey represents a summer snapshot of phytoplankton biomass and its drivers, and lends support that light and stratification metrics, which are both affected by climate change, are better predictors for phytoplankton biomass in nutrient-rich lakes than nutrient concentrations and surface temperature.

Published
2021
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13. Antioxidant activity and total phenolic contents of Galanthus woronowii (Amaryllidaceae)

Author

GENÇ, Nusret, YILDIZ, İlyas, KARAN, Tunay, EMİNAĞAOĞLU, Özgür, and ERENLER, Ramazan

Subjects
Galanthus woronowii,antioxidant activity,phenolic contents,natural product, Galanthus woronowii,doğal ürün,antioksidan aktivite,Fenolik içerik, Basic Sciences, Temel Bilimler
Abstract

Bitkilereski çağlardan beri tıbbi amaçlarla kullanılmaktadır. İçerdikleri biyoaktifsekonder metabolitlerden dolayı, bitkiler ilaç keşfi ve gelişimi için oldukçafazla ilgi görmektedir. Bu çalışmada, Galanthusworonowii türüne ait bitki materyalleri sırasıyla hekzan, diklorometan veetil asetat ile ekstrakte edilmiştir. Çözücü dönerli buharlaştırıcı ileuzaklaştırıldıktan sonra ham ekstraktlar elde edilmiştir. Ekstraktların DPPHserbest radikal giderme, ABTS radikal katyon giderme ve indirgeme gücüaktiviteleri değerlendirilmiştir. Ayrıca toplan fenolik içerik belirlenmiştir.Etil asetat ekstraktının en çok fenolik içerdiği ve en yüksek antioksidanaktivite gösterdiği belirlenmiştir. Bu nedenlerle, bu bitki ümit vericiantioksidan ajan olarak kabul edilebilir., Plantshave been used for medicinal purpose since ancient times. Due to the includingbioactive secondary metabolites, plants have gained the great interest for drugdiscovery and development process. In this work, Galanthus woronowii was extracted with hexane, dichloromethane andethyl acetate sequentially. After removing of the solvent by rotary evaporator, crude extracts were yielded. Antioxidant activity including 1,1-diphenyl-2-picrylhydrazyl (DPPH), 2,2'-azino-bis(3-ethylbenzothiazoline-6-sulphonicacid) (ABTS) and reducing power assays were executed on corresponding extracts. In addition, total phenolic content was presented. Ethyl acetate extractincluded the most phenolic compounds and also it revealed the most antioxidantactivity. Hence, this plant could be considered as a promising antioxidantagent.

Published
2019

14. Fatty acid constituents and anticancer activity of Cladophora fracta (OF Muller ex Vahl) Kutzing

Author

Karan, Tunay and Erenler, Ramazan

Subjects
Cladophora fracta, Antiproliferative activity, Anti-cancer, Cytotoxic effect, Fatty acid, Anti-cancer, Cytotoxic effect, Antiproliferative activity, Fatty acid, Cladophora fracta
Abstract

Purpose: To determine the fatty acid constituents and anticancer effect of Cladohora fractaMethods: Cladophora fracta (O.F. Müller ex Vahl) Kützing was collected from natural ponds in Tokat, Turkey. Antiproliferative and cytotoxic effects of methanol and hexane extracts of C. fracta were investigated on human colon carcinoma (HT29) and non-tumorigenic African green monkey kidney (Vero) cell lines using BrdU cell proliferation enzyme-linked Immunosorbent assay (ELISA) and lactate dehydrogenase (LDH) test, respectively. The fatty acid composition of hexane extract was analyzed by gas chromatography-mass spectrometry (GC-MS).Results: Oleic acid, palmitic acid, gamma-linoleic acid and linoleic acid were the main constituents of C. fracta. The methanol extract exhibited strong antiproliferative activity on HT29 and Vero cell lines (p < 0.05). The hexane extract revealed its good antiproliferative activity at high concentrations on both cell lines. Cytotoxicity results showed that both methanol and hexane extract had low effect on HT29 cell at low concentrations.Conclusion: Due to the strong antiproliferative effect of C. fracta methanol extract on HT29 and Vero cell lines, it has potential anticancer properties and recommended for further development as such.Keywords: Cladophora fracta, Antiproliferative activity, Anti-cancer, Cytotoxic effect, Fatty acid

Published
2018

17. Temperature Effects Explain Continental Scale Distribution of Cyanobacterial Toxins

Author

Mantzouki, Evanthia, Lurling, Miquel, Fastner, Jutta, Domis, Lisette de Senerpont, Wilk-Wozniak, Elzbieta, Koreiviene, Judita, Seelen, Laura, Teurlincx, Sven, Verstijnen, Yvon, Krzton, Wojciech, Walusiak, Edward, Karosiene, Jurate, Kasperoviciene, Jurate, Savadova, Ksenija, Vitonyte, Irma, Cillero-Castro, Carmen, Budzynska, Agnieszka, Goldyn, Ryszard, Kozak, Anna, Rosinska, Joanna, Szelag-Wasielewska, Elzbieta, Domek, Piotr, Jakubowska-Krepska, Natalia, Kwasizur, Kinga, Messyasz, Beata, Pelechata, Aleksandra, Pelechaty, Mariusz, Kokocinski, Mikolaj, Garcia-Murcia, Ana, Real, Monserrat, Romans, Elvira, Noguero-Ribes, Jordi, Parreno Duque, David, Fernandez-Moran, Elisabeth, Karakaya, Nusret, Haggqvist, Kerstin, Demir, Nilsun, Beklioglu, Meryem, Filiz, Nur, Levi, Eti E., Iskin, Ugur, Bezirci, Gizem, Tavsanoglu, Ulku Nihan, Ozhan, Koray, Gkelis, Spyros, Panou, Manthos, Fakioglu, Ozden, Avagianos, Christos, Kaloudis, Triantafyllos, Celik, Kemal, Yilmaz, Mete, Marce, Rafael, Catalán, Núria, Bravo, Andrea Garcia, Buck, Moritz, Colom-Montero, William, Mustonen, Kristiina, Pierson, Don, Yang, Yang, Raposeiro, Pedro M., Goncalves, Vitor, Antoniou, Maria G., Tsiarta, Nikoletta, McCarthy, Valerie, Perello, Victor C., Feldmann, Tonu, Laas, Alo, Panksep, Kristel, Tuvikene, Lea, Gagala, Ilona, Mankiewicz-Boczek, Joana, Yagci, Meral Apaydin, Cinar, Sakir, Capkin, Kadir, Yagci, Abdulkadir, Cesur, Mehmet, Bilgin, Fuat, Bulut, Cafer, Uysal, Rahmi, Obertegger, Ulrike, Boscaini, Adriano, Flaim, Giovanna, Salmaso, Nico, Cerasino, Leonardo, Richardson, Jessica, Visser, Petra M., Verspagen, Jolanda M. H., Karan, Tunay, Soylu, Elif Neyran, Maraslioglu, Faruk, Napiorkowska-Krzebietke, Agnieszka, Ochocka, Agnieszka, Pasztaleniec, Agnieszka, Antao-Geraldes, Ana M., Vasconcelos, Vitor, Morais, Joao, Vale, Micaela, Koker, Latife, Akcaalan, Reyhan, Albay, Meric, Maronic, Dubravka Spoljaric, Stevic, Filip, Pfeiffer, Tanja Zuna, Fonvielle, Jeremy, Straile, Dietmar, Rothhaupt, Karl-Otto, Hansson, Lars-Anders, Urrutia Cordero, Pablo, Blaha, Ludek, Geris, Rodan, Frankova, Marketa, Kocer, Mehmet Ali Turan, Alp, Mehmet Tahir, Remec-Rekar, Spela, Elersek, Tina, Triantis, Theodoros, Zervou, Sevasti-Kiriaki, Hiskia, Anastasia, Haande, Sigrid, Skjelbred, Birger, Madrecka, Beata, Nemova, Hana, Drastichova, Iveta, Chomova, Lucia, Edwards, Christine, Sevindik, Tugba Ongun, Tunca, Hatice, OEnem, Burcin, Aleksovski, Boris, Krstic, Svetislav, Vucelic, Itana Bokan, Nawrocka, Lidia, Salmi, Pauliina, Machado-Vieira, Danielle, de Oliveira, Alinne Gurjao, Delgado-Martin, Jordi, Garcia, David, Cereijo, Jose Luis, Goma, Joan, Trapote, Mari Carmen, Vegas-Vilarrubia, Teresa, Obrador, Biel, Grabowska, Magdalena, Karpowicz, Maciej, Chmura, Damian, Ubeda, Barbara, Angel Galvez, Jose, Ozen, Arda, Christoffersen, Kirsten Seestern, Warming, Trine Perlt, Kobos, Justyna, Mazur-Marzec, Hanna, Perez-Martinez, Carmen, Ramos-Rodriguez, Eloisa, Arvola, Lauri, Alcaraz-Parraga, Pablo, Toporowska, Magdalena, Pawlik-Skowronska, Barbara, Niedzwiecki, Michal, Peczula, Wojciech, Leira, Manel, Hernandez, Armand, Moreno-Ostos, Enrique, Maria Blanco, Jose, Rodriguez, Valeriano, Juan Montes-Perez, Jorge, Palomino, Roberto L., Rodriguez-Perez, Estela, Carballeira, Rafael, Camacho, Antonio, Picazo, Antonio, Rochera, Carlos, Santamans, Anna C., Ferriol, Carmen, Romo, Susana, Miguel Soria, Juan, Dunalska, Julita, Sienska, Justyna, Szymanski, Daniel, Kruk, Marek, Kostrzewska-Szlakowska, Iwona, Jasser, Iwona, Zutinic, Petar, Udovic, Marija Gligora, Plenkovic-Moraj, Andelka, Frak, Magdalena, Bankowska-Sobczak, Agnieszka, Wasilewicz, Michal, Ozkan, Korhan, Maliaka, Valentini, Kangro, Kersti, Grossart, Hans-Peter, Paerl, Hans W., Carey, Cayelan C., Ibelings, Bas W., Mantzouki, Evanthia, Lurling, Miquel, Fastner, Jutta, Domis, Lisette de Senerpont, Wilk-Wozniak, Elzbieta, Koreiviene, Judita, Seelen, Laura, Teurlincx, Sven, Verstijnen, Yvon, Krzton, Wojciech, Walusiak, Edward, Karosiene, Jurate, Kasperoviciene, Jurate, Savadova, Ksenija, Vitonyte, Irma, Cillero-Castro, Carmen, Budzynska, Agnieszka, Goldyn, Ryszard, Kozak, Anna, Rosinska, Joanna, Szelag-Wasielewska, Elzbieta, Domek, Piotr, Jakubowska-Krepska, Natalia, Kwasizur, Kinga, Messyasz, Beata, Pelechata, Aleksandra, Pelechaty, Mariusz, Kokocinski, Mikolaj, Garcia-Murcia, Ana, Real, Monserrat, Romans, Elvira, Noguero-Ribes, Jordi, Parreno Duque, David, Fernandez-Moran, Elisabeth, Karakaya, Nusret, Haggqvist, Kerstin, Demir, Nilsun, Beklioglu, Meryem, Filiz, Nur, Levi, Eti E., Iskin, Ugur, Bezirci, Gizem, Tavsanoglu, Ulku Nihan, Ozhan, Koray, Gkelis, Spyros, Panou, Manthos, Fakioglu, Ozden, Avagianos, Christos, Kaloudis, Triantafyllos, Celik, Kemal, Yilmaz, Mete, Marce, Rafael, Catalán, Núria, Bravo, Andrea Garcia, Buck, Moritz, Colom-Montero, William, Mustonen, Kristiina, Pierson, Don, Yang, Yang, Raposeiro, Pedro M., Goncalves, Vitor, Antoniou, Maria G., Tsiarta, Nikoletta, McCarthy, Valerie, Perello, Victor C., Feldmann, Tonu, Laas, Alo, Panksep, Kristel, Tuvikene, Lea, Gagala, Ilona, Mankiewicz-Boczek, Joana, Yagci, Meral Apaydin, Cinar, Sakir, Capkin, Kadir, Yagci, Abdulkadir, Cesur, Mehmet, Bilgin, Fuat, Bulut, Cafer, Uysal, Rahmi, Obertegger, Ulrike, Boscaini, Adriano, Flaim, Giovanna, Salmaso, Nico, Cerasino, Leonardo, Richardson, Jessica, Visser, Petra M., Verspagen, Jolanda M. H., Karan, Tunay, Soylu, Elif Neyran, Maraslioglu, Faruk, Napiorkowska-Krzebietke, Agnieszka, Ochocka, Agnieszka, Pasztaleniec, Agnieszka, Antao-Geraldes, Ana M., Vasconcelos, Vitor, Morais, Joao, Vale, Micaela, Koker, Latife, Akcaalan, Reyhan, Albay, Meric, Maronic, Dubravka Spoljaric, Stevic, Filip, Pfeiffer, Tanja Zuna, Fonvielle, Jeremy, Straile, Dietmar, Rothhaupt, Karl-Otto, Hansson, Lars-Anders, Urrutia Cordero, Pablo, Blaha, Ludek, Geris, Rodan, Frankova, Marketa, Kocer, Mehmet Ali Turan, Alp, Mehmet Tahir, Remec-Rekar, Spela, Elersek, Tina, Triantis, Theodoros, Zervou, Sevasti-Kiriaki, Hiskia, Anastasia, Haande, Sigrid, Skjelbred, Birger, Madrecka, Beata, Nemova, Hana, Drastichova, Iveta, Chomova, Lucia, Edwards, Christine, Sevindik, Tugba Ongun, Tunca, Hatice, OEnem, Burcin, Aleksovski, Boris, Krstic, Svetislav, Vucelic, Itana Bokan, Nawrocka, Lidia, Salmi, Pauliina, Machado-Vieira, Danielle, de Oliveira, Alinne Gurjao, Delgado-Martin, Jordi, Garcia, David, Cereijo, Jose Luis, Goma, Joan, Trapote, Mari Carmen, Vegas-Vilarrubia, Teresa, Obrador, Biel, Grabowska, Magdalena, Karpowicz, Maciej, Chmura, Damian, Ubeda, Barbara, Angel Galvez, Jose, Ozen, Arda, Christoffersen, Kirsten Seestern, Warming, Trine Perlt, Kobos, Justyna, Mazur-Marzec, Hanna, Perez-Martinez, Carmen, Ramos-Rodriguez, Eloisa, Arvola, Lauri, Alcaraz-Parraga, Pablo, Toporowska, Magdalena, Pawlik-Skowronska, Barbara, Niedzwiecki, Michal, Peczula, Wojciech, Leira, Manel, Hernandez, Armand, Moreno-Ostos, Enrique, Maria Blanco, Jose, Rodriguez, Valeriano, Juan Montes-Perez, Jorge, Palomino, Roberto L., Rodriguez-Perez, Estela, Carballeira, Rafael, Camacho, Antonio, Picazo, Antonio, Rochera, Carlos, Santamans, Anna C., Ferriol, Carmen, Romo, Susana, Miguel Soria, Juan, Dunalska, Julita, Sienska, Justyna, Szymanski, Daniel, Kruk, Marek, Kostrzewska-Szlakowska, Iwona, Jasser, Iwona, Zutinic, Petar, Udovic, Marija Gligora, Plenkovic-Moraj, Andelka, Frak, Magdalena, Bankowska-Sobczak, Agnieszka, Wasilewicz, Michal, Ozkan, Korhan, Maliaka, Valentini, Kangro, Kersti, Grossart, Hans-Peter, Paerl, Hans W., Carey, Cayelan C., and Ibelings, Bas W.

Abstract

Insight into how environmental change determines the production and distribution of cyanobacterial toxins is necessary for risk assessment. Management guidelines currently focus on hepatotoxins (microcystins). Increasing attention is given to other classes, such as neurotoxins (e.g., anatoxin-a) and cytotoxins (e.g., cylindrospermopsin) due to their potency. Most studies examine the relationship between individual toxin variants and environmental factors, such as nutrients, temperature and light. In summer 2015, we collected samples across Europe to investigate the effect of nutrient and temperature gradients on the variability of toxin production at a continental scale. Direct and indirect effects of temperature were the main drivers of the spatial distribution in the toxins produced by the cyanobacterial community, the toxin concentrations and toxin quota. Generalized linear models showed that a Toxin Diversity Index (TDI) increased with latitude, while it decreased with water stability. Increases in TDI were explained through a significant increase in toxin variants such as MC-YR, anatoxin and cylindrospermopsin, accompanied by a decreasing presence of MC-LR. While global warming continues, the direct and indirect effects of increased lake temperatures will drive changes in the distribution of cyanobacterial toxins in Europe, potentially promoting selection of a few highly toxic species or strains.

Published
2018
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18. Data Descriptor: A European Multi Lake Survey dataset of environmental variables, phytoplankton pigments and cyanotoxins

Author

Mantzouki, Evanthia, Campbell, James, van Loon, Emiel, Visser, Petra, Konstantinou, Iosif, Antoniou, Maria, Giuliani, Gregory, Machado-Vieira, Danielle, de Oliveira, Alinne Gurjao, Maronic, Dubravka Spoljaric, Stevic, Filip, Pfeiffer, Tanja Zuna, Vucelic, Itana Bokan, Zutinic, Petar, Udovic, Marija Gligora, Plenkovic-Moraj, Andelka, Tsiarta, Nikoletta, Blaha, Ludek, Geris, Rodan, Frankova, Marketa, Christoffersen, Kirsten Seestern, Warming, Trine Perlt, Feldmann, Tonu, Laas, Alo, Panksep, Kristel, Tuvikene, Lea, Kangro, Kersti, Haggqvist, Kerstin, Salmi, Pauliina, Arvola, Lauri, Fastner, Jutta, Straile, Dietmar, Rothhaupt, Karl-Otto, Fonvielle, Jeremy, Grossart, Hans-Peter, Avagianos, Christos, Kaloudis, Triantafyllos, Triantis, Theodoros, Zervou, Sevasti-Kiriaki, Hiskia, Anastasia, Gkelis, Spyros, Panou, Manthos, McCarthy, Valerie, Perello, Victor C., Obertegger, Ulrike, Boscaini, Adriano, Flaim, Giovanna, Salmaso, Nico, Cerasino, Leonardo, Koreiviene, Judita, Karosiene, Jurate, Kasperoviciene, Jurate, Savadova, Ksenija, Vitonyte, Irma, Haande, Sigrid, Skjelbred, Birger, Grabowska, Magdalena, Karpowicz, Maciej, Chmura, Damian, Nawrocka, Lidia, Kobos, Justyna, Mazur-Marzec, Hanna, Alcaraz-Parraga, Pablo, Wilk-Wozniak, Elzbieta, Krzton, Wojciech, Walusiak, Edward, Gagala, Ilona, Mankiewicz-Boczek, Joana, Toporowska, Magdalena, Pawlik-Skowronska, Barbara, Niedzwiecki, Michal, Peczula, Wojciech, Napiorkowska-Krzebietke, Agnieszka, Dunalska, Julita, Sienska, Justyna, Szymanski, Daniel, Kruk, Marek, Budzynska, Agnieszka, Goldyn, Ryszard, Kozak, Anna, Rosinska, Joanna, Szelag-Wasielewska, Elzbieta, Domek, Piotr, Jakubowska-Krepska, Natalia, Kwasizur, Kinga, Messyasz, Beata, Pelechata, Aleksandra, Pelechaty, Mariusz, Kokocinski, Mikolaj, Madrecka, Beata, Kostrzewska-Szlakowska, Iwona, Frak, Magdalena, Bankowska-Sobczak, Agnieszka, Wasilewicz, Michal, Ochocka, Agnieszka, Pasztaleniec, Agnieszka, Jasser, Iwona, Antao-Geraldes, Ana M., Leira, Manel, Hernandez, Armand, Vasconcelos, Vitor, Morais, Joao, Vale, Micaela, Raposeiro, Pedro M., Goncalves, Vitor, Aleksovski, Boris, Krstic, Svetislav, Nemova, Hana, Drastichova, Iveta, Chomova, Lucia, Remec-Rekar, Spela, Elersek, Tina, Delgado-Martin, Jordi, Garcia, David, Luis Cereijo, Jose, Goma, Joan, Carmen Trapote, Mari, Vegas-Vilarrubia, Teresa, Obrador, Biel, Garcia-Murcia, Ana, Real, Monserrat, Romans, Elvira, Noguero-Ribes, Jordi, Parreno Duque, David, Fernandez-Moran, Elisabeth, Ubeda, Barbara, Angel Galvez, Jose, Marce, Rafael, Catalan, Nuria, Perez-Martinez, Carmen, Ramos-Rodriguez, Eloisa, Cillero-Castro, Carmen, Moreno-Ostos, Enrique, Maria Blanco, Jose, Rodriguez, Valeriano, Juan Montes-Perez, Jorge, Palomino, Roberto L., Rodriguez-Perez, Estela, Carballeira, Rafael, Camacho, Antonio, Picazo, Antonio, Rochera, Carlos, Santamans, Anna C., Ferriol, Carmen, Romo, Susana, Soria, Juan Miguel, Hansson, Lars-Anders, Urrutia-Cordero, Pablo, Ozen, Arda, Bravo, Andrea G., Buck, Moritz, Colom-Montero, William, Mustonen, Kristiina, Pierson, Don, Yang, Yang, Verspagen, Jolanda M. H., Domis, Lisette N. de Senerpont, Seelen, Laura, Teurlincx, Sven, Verstijnen, Yvon, Lurling, Miquel, Maliaka, Valentini, Faassen, Elisabeth J., Latour, Delphine, Carey, Cayelan C., Paerl, Hans W., Torokne, Andrea, Karan, Tunay, Demir, Nilsun, Beklioglu, Meryem, Filiz, Nur, Levi, Eti E., Iskin, Ugur, Bezirci, Gizem, Tavsanoglu, Ulku Nihan, Celik, Kemal, Ozhan, Koray, Karakaya, Nusret, Kocer, Mehmet Ali Turan, Yilmaz, Mete, Maraslioglu, Faruk, Fakioglu, Ozden, Soylu, Elif Neyran, Yagci, Meral Apaydin, Cinar, Sakir, Capkin, Kadir, Yagci, Abdulkadir, Cesur, Mehmet, Bilgin, Fuat, Bulut, Cafer, Uysal, Rahmi, Koker, Latife, Akcaalan, Reyhan, Albay, Meric, Alp, Mehmet Tahir, Ozkan, Korhan, Sevindik, Tugba Ongun, Tunca, Hatice, Onem, Burcin, Richardson, Jessica, Edwards, Christine, Bergkemper, Victoria, O'Leary, Sarah, Beirne, Eilish, Cromie, Hannah, Ibelings, Bastiaan W., Mantzouki, Evanthia, Campbell, James, van Loon, Emiel, Visser, Petra, Konstantinou, Iosif, Antoniou, Maria, Giuliani, Gregory, Machado-Vieira, Danielle, de Oliveira, Alinne Gurjao, Maronic, Dubravka Spoljaric, Stevic, Filip, Pfeiffer, Tanja Zuna, Vucelic, Itana Bokan, Zutinic, Petar, Udovic, Marija Gligora, Plenkovic-Moraj, Andelka, Tsiarta, Nikoletta, Blaha, Ludek, Geris, Rodan, Frankova, Marketa, Christoffersen, Kirsten Seestern, Warming, Trine Perlt, Feldmann, Tonu, Laas, Alo, Panksep, Kristel, Tuvikene, Lea, Kangro, Kersti, Haggqvist, Kerstin, Salmi, Pauliina, Arvola, Lauri, Fastner, Jutta, Straile, Dietmar, Rothhaupt, Karl-Otto, Fonvielle, Jeremy, Grossart, Hans-Peter, Avagianos, Christos, Kaloudis, Triantafyllos, Triantis, Theodoros, Zervou, Sevasti-Kiriaki, Hiskia, Anastasia, Gkelis, Spyros, Panou, Manthos, McCarthy, Valerie, Perello, Victor C., Obertegger, Ulrike, Boscaini, Adriano, Flaim, Giovanna, Salmaso, Nico, Cerasino, Leonardo, Koreiviene, Judita, Karosiene, Jurate, Kasperoviciene, Jurate, Savadova, Ksenija, Vitonyte, Irma, Haande, Sigrid, Skjelbred, Birger, Grabowska, Magdalena, Karpowicz, Maciej, Chmura, Damian, Nawrocka, Lidia, Kobos, Justyna, Mazur-Marzec, Hanna, Alcaraz-Parraga, Pablo, Wilk-Wozniak, Elzbieta, Krzton, Wojciech, Walusiak, Edward, Gagala, Ilona, Mankiewicz-Boczek, Joana, Toporowska, Magdalena, Pawlik-Skowronska, Barbara, Niedzwiecki, Michal, Peczula, Wojciech, Napiorkowska-Krzebietke, Agnieszka, Dunalska, Julita, Sienska, Justyna, Szymanski, Daniel, Kruk, Marek, Budzynska, Agnieszka, Goldyn, Ryszard, Kozak, Anna, Rosinska, Joanna, Szelag-Wasielewska, Elzbieta, Domek, Piotr, Jakubowska-Krepska, Natalia, Kwasizur, Kinga, Messyasz, Beata, Pelechata, Aleksandra, Pelechaty, Mariusz, Kokocinski, Mikolaj, Madrecka, Beata, Kostrzewska-Szlakowska, Iwona, Frak, Magdalena, Bankowska-Sobczak, Agnieszka, Wasilewicz, Michal, Ochocka, Agnieszka, Pasztaleniec, Agnieszka, Jasser, Iwona, Antao-Geraldes, Ana M., Leira, Manel, Hernandez, Armand, Vasconcelos, Vitor, Morais, Joao, Vale, Micaela, Raposeiro, Pedro M., Goncalves, Vitor, Aleksovski, Boris, Krstic, Svetislav, Nemova, Hana, Drastichova, Iveta, Chomova, Lucia, Remec-Rekar, Spela, Elersek, Tina, Delgado-Martin, Jordi, Garcia, David, Luis Cereijo, Jose, Goma, Joan, Carmen Trapote, Mari, Vegas-Vilarrubia, Teresa, Obrador, Biel, Garcia-Murcia, Ana, Real, Monserrat, Romans, Elvira, Noguero-Ribes, Jordi, Parreno Duque, David, Fernandez-Moran, Elisabeth, Ubeda, Barbara, Angel Galvez, Jose, Marce, Rafael, Catalan, Nuria, Perez-Martinez, Carmen, Ramos-Rodriguez, Eloisa, Cillero-Castro, Carmen, Moreno-Ostos, Enrique, Maria Blanco, Jose, Rodriguez, Valeriano, Juan Montes-Perez, Jorge, Palomino, Roberto L., Rodriguez-Perez, Estela, Carballeira, Rafael, Camacho, Antonio, Picazo, Antonio, Rochera, Carlos, Santamans, Anna C., Ferriol, Carmen, Romo, Susana, Soria, Juan Miguel, Hansson, Lars-Anders, Urrutia-Cordero, Pablo, Ozen, Arda, Bravo, Andrea G., Buck, Moritz, Colom-Montero, William, Mustonen, Kristiina, Pierson, Don, Yang, Yang, Verspagen, Jolanda M. H., Domis, Lisette N. de Senerpont, Seelen, Laura, Teurlincx, Sven, Verstijnen, Yvon, Lurling, Miquel, Maliaka, Valentini, Faassen, Elisabeth J., Latour, Delphine, Carey, Cayelan C., Paerl, Hans W., Torokne, Andrea, Karan, Tunay, Demir, Nilsun, Beklioglu, Meryem, Filiz, Nur, Levi, Eti E., Iskin, Ugur, Bezirci, Gizem, Tavsanoglu, Ulku Nihan, Celik, Kemal, Ozhan, Koray, Karakaya, Nusret, Kocer, Mehmet Ali Turan, Yilmaz, Mete, Maraslioglu, Faruk, Fakioglu, Ozden, Soylu, Elif Neyran, Yagci, Meral Apaydin, Cinar, Sakir, Capkin, Kadir, Yagci, Abdulkadir, Cesur, Mehmet, Bilgin, Fuat, Bulut, Cafer, Uysal, Rahmi, Koker, Latife, Akcaalan, Reyhan, Albay, Meric, Alp, Mehmet Tahir, Ozkan, Korhan, Sevindik, Tugba Ongun, Tunca, Hatice, Onem, Burcin, Richardson, Jessica, Edwards, Christine, Bergkemper, Victoria, O'Leary, Sarah, Beirne, Eilish, Cromie, Hannah, and Ibelings, Bastiaan W.

Published
2018

19. Antibacterial Activity of Essential Oils of Origanum bilgeri, Origanum onites, Satureja spicigeraLeaves Against Agricultural Plant Pathogenic Bacteria

Author

Karan, Tunay, Belguzar, Sabriye, and Selvi, Bedrettin

Abstract

AbstractNatural products have gained a great interest to fight against pathogens recently. In this study, essential oils of Origanum bilgeri, Origanum onitesand Satureja spicigeraleaves were obtained by steam distillation using Clevenger type apparatus and compounds were identified by gas chromatography-mass spectrometry (GC/MS) analysis. Antimicrobial activities of essential oils were carried out using the Clavibacter michiganensissubsp. michiganensis(Cmm), Xanthomonas axonopodispv. vesicatoria(Xav) and Pseudomonas syringaepv. tomato(Pst). O. bilgeriessential oil has a significant effect on (100 %) all pathogens with dose dependence. O. onitesessential oil has a great effect against Cmm and Xav bacteria with the dose of 7.5 μL. The S. spicigeraessential oil has an inhibition effect on Cmm at a 7.5 μL dose. Moreover, this essential oil inhibited the Xav at 94 % at 10 μL. Consequently, the corresponding essential oils could be a natural pesticide candidate for the agricultural industry.

Published
2021
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20. Growth and Metabolite Production of Chroococcus minutus Under Different Temperature and Light Conditions

Author

Erenler, Ramazan, Karan, Tunay, and Altuner, Zekeriya

Subjects
Chroococcus minutus,norharmane,HPLC,temperature
Abstract

Cyanobacteriaconsisting of valuable bioactive compounds reveal the pharmaceutical andbiological activities. In this work, the sample was collected from freshwaterand was isolated under inverted microscope. Identification was carried out bymorphologically. The isolated Chroococcus minutus was cultivated inBristol nutrient medium. Growth and norharmane production of Chroococcusminutus under temperature and light conditions were presented. The most norharmane production and the cell numberswere observed at 35 °C and irradiation of 1896 lux as 4.017 µg/g and 154.3 µg/grespectively.&nbsp

Published
2017

31. Anticancer potential and cytotoxic effect of some freshwater cyanobacteria.

Author

Karan, Tunay and Aydin, Ali

Subjects
*CYANOBACTERIA, *ANTINEOPLASTIC agents, *COLON cancer treatment, *ANIMAL models of cancer, *BREAST cancer treatment, *LIVER cancer, *CELL-mediated cytotoxicity
Abstract

Purpose: To investigate the anticancer potential and cytotoxicity of some freshwater cyanobacterial extracts on Human Colon Carcinoma (HT29), Rat Brain Glioma (C6), Human Cervix Carcinoma (HeLa), Human Lung Carcinoma (A549), Human Breast Adenocarcinoma (MCF7), Human Liver Hepatocellular Carcinoma (Hep3B) cancerous cells, African Green Monkey Kidney cells (Vero), and Human Amnion cells (FL). Methods: Chroococus minutus, Geitlerinema carotinosum, Nostoc linckia and Anabaena oryzae were collected from different freshwater habitats and identified. Each cyanobacterium was extracted with methanol. Antiproliferative activities of the cyanobacterial extracts were evaluated by [3-(4, 5- dimethylthiazolyl-2)-2,5-diphenyltetrazolium bromide] (MTT) using HT29, C6, HeLa, A549, MCF7, Hep3B, Vero, and FL cell lines. Cytotoxicity was determined by lactate dehydrogenase (LDH) assay. Results: The cyanobacterial extracts showed varying antiproliferative and cytotoxic effects on cancer cells. G. carotinosum and N. linckia had significant inhibitory effect on C6 cell lines with half-maximal inhibitory (IC50) levels of 112.69 and 121.48 µg/mL, respectively. TGI values for G. carotinosum and N. linckia were 65.07 and 70.61 µg/mL, respectively. LC50 values for these two cyanobacteria were 386.64 and 760.55 µg/mL, respectively. In addition, cyanobacterium A. oryzae displayed excellent antiproliferative effect on MCF7 cancer cells (GI50 = 2.04 µg/mL). The extracts displayed the cytostatic effect on the cell lines. Conclusion: G. carotinosum, N. linckia and A. oryzae exhibit significant activity on various cancer cells. Hence these cyanobacteria may offer promise as anticancer agents. [ABSTRACT FROM AUTHOR]

Published
2018
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32. Biogenic synthesis of silver nanoparticles using Consolida orientalisflowers: Identification, catalytic degradation, and biological effect

Author

Karan, Tunay

Abstract

Silver nanoparticles have attracted great attention due to their important usage areas recently. Silver nanoparticles were synthesized via Consolida orientalisflowers by green approach. The spectroscopic analyses characterized the synthesized silver nanoparticles (AgNPs@Co). The surface plasmon resonance of AgNPs@Co was determined as 425 nm by UV-Vis. The particle size was determined by X-ray diffraction (XRD) as 9.7 nm using the Scherrer equation. XRD analysis at 2θwith the angle of 38.17°, 44.29°, 57.49°, and 77.36° corresponded to planes [111, 020, 202, and 131] demonstrating the fcc structure. In addition, transmission electron microscopy analysis presented the particle size to be 11.9 nm as spherical. The functional moiety of bioactive compounds was displayed by Fourier-transform infrared spectroscopy analysis, and a characteristic hydroxyl was detected at 3,274 cm−1. The zeta potential revealed the stability of nanoparticles as −20.3 mV. The signals at 2.3–3.4 keV in energy-dispersive X-ray spectroscopy proved the nanostructure. The catalytic activity of AgNPs@Co was executed using methylene blue in the treatment of sodium borohydride and degradation was determined as 71% in 45 min. Antioxidant of extract and nanoparticles was carried out using 2,2-Diphenyl-1-picrylhydrazyl (DPPH), 2,2′-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid) and superoxide assays. The nanoparticles and extract exhibited good antioxidant activity with the values of 9.3 ± 0.2 and 11.2 ± 0.6 in the DPPH assay, respectively, in comparison with the standard butyl hydroxyanisole (6.5 ± 0.4). The silver nanoparticles may be a good antioxidant agent for drug development and the food industry.

Published
2023
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34. Phenylthiocarbamide taste perception as a possible genetic association marker for nutritional habits and obesity tendency of people.

Author

Dastan, Sevgi Durna, Degerli, Naci, Dastan, Taner, Yildiz, Fazilet, Yildi, Yavuz, Durna, Yusuf Muhammed, Atessahin, Dilek, and Karan, Tunay

Abstract

Ability to taste Phenylthiocarbamide (PTC) a bitter molecule, is usually used to know the heritable characteristic in both genetic and physiological studies. So far, no research has yet attested whether PTC blindness relation with obesity and some nutrition behaviors of human. This study is the first attempt on a large scale to examine PTC sensitivity in healthy and overweight people in Turkish population to define in the perception of bitter senses which is associated with nutrition habits, body mass index, age, gender, and to be in stable weight. PTC taste perception was measured by tasting PTC solution filtered in a paper. The results showed that tasters were significantly more frequent (81,8%) than nontasters (18,2%) in all population. A higher proportion of nontasters were observed in the quite fat individual group (BMI ≥40kg/m²). Alterations explained these differences in basic taste sensitivity, age, gender, BMI, individuals' family obesity situations, vegetarian nourishment. Increased frequency of nontasters allele is evident with obesity condition. This could be due to lack of preference for nutrition among nontasters. So the phenotypic variation in PTC sensitivity is genetic in origin; it may represent an association with obesity, dietary habits, regular weight, gender, and age. [ABSTRACT FROM AUTHOR]

Published
2015

35. Screening of Norharmane from Seven Cyanobacteria by High-performance Liquid Chromatography.

Author

Karan, Tunay and Erenler, Ramazan

Subjects
*CYANOBACTERIA, *HIGH performance liquid chromatography, *METABOLITE synthesis, *DINOFLAGELLATES, *PHOTODIODE testing, *THERAPEUTICS
Abstract

Background: Cyanobacteria, including pharmaceutically and medicinally valuable compounds attract the great attention lately. Norharmane (9H-pyrido (3,4-b) indole found in some cyanobacteria revealed a great number of biological effects. Objective: Seven cyanobacteria were isolated and identified from Yesilirmak River and Gaziosmanpasa University Campus to determine the norharmane content. Materials and Methods: Cyanobacteria collected from Tokat, Turkey were isolated and identified by morphologically. Norharmane (9H-pyrido [3,4-b] indole) quantities were presented for seven cyanobacteria, Chroococcus minutus (Kütz.) Nägeli, Geitlerinema carotinosum (Geitler) Anagnostidis, Nostoc linckia Bornet ex Bornet and Flahault, Anabaena oryzae F. E. Fritsch, Oscillatoria limnetica Lemmermann, Phormidium sp. Kützing ex Gomont, and Cylindrospermum sp. Kutzing ex E. Bornet and C. Flahault by high-performance liquid chromatography. Results: The norharmane amount indicated for cyanobacterial culture media altered in a species-dependent kind in the range of 0.81-10.87 µg/g. C. minutus produced the most norharmane among the investigated cyanobacteria as 10.87 µg/g. Conclusion: Cyanobacteria could be an important source of norharmane as well as pharmaceutically valuable compounds. [ABSTRACT FROM AUTHOR]

Published
2017
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36. Phenylthiocarbamide taste perception as a possible genetic association marker for nutritional habits and obesity tendency of people

Author

Dastan, S., NACI DEGERLI, Dastan, T., Yildiz, F., Yildir, Y., Durna, Y. M., Atessahin, D., Karan, T., [Dastan, Sevgi Durna] Cumhuriyet Univ, Fac Vet, Dept Zootech & Anim Nutr, Sivas, Turkey -- [Degerli, Naci] Cumhuriyet Univ, Fac Sci, Dept Mol Biol & Genet, Sivas, Turkey -- [Dastan, Taner] Bingol Univ, Fac Arts & Sci, Dept Chem, Bingol, Turkey -- [Yildiz, Fazilet] Okan Univ, Tuzla Campus Vocat Sch Hlth Serv, Istanbul, Turkey -- [Yildir, Yavuz] Cumhuriyet Univ, Fac Sci, Dept Biol, Sivas, Turkey -- [Durna, Yusuf Muhammed] Istanbul Training & Res Hosp, Dept Otorhinolaryngol, Istanbul, Turkey -- [Atessahin, Dilek] Firat Univ, Fac Arts & Sci, Dept Biol, TR-23169 Elazig, Turkey -- [Karan, Tunay] Gazi Osman Pasa Univ, Fac Arts & Sci, Dept Biol, Tokat, Turkey, and karan, tunay -- 0000-0002-9114-8400

Subjects
obesity, PTC taste sensitivity, taste genetics, nontaster PTC trait, food preference
Abstract

WOS: 000358108900019, PubMed ID: 26051736, Ability to taste Phenylthiocarbamide (PTC) a bitter molecule, is usually used to know the heritable characteristic in both genetic and physiological studies. So far, no research has yet attested whether PTC blindness relation with obesity and some nutrition behaviors of human. This stu.dy is the first attempt on a large scale to examine PTC sensitivity in healthy and overweight people in Turkish population to define in the perception of bitter senses which is associated with nutrition habits, body mass index, age, gender, and to be in stable weight. PTC taste perception was measured by tasting PTC solution filtered in a paper. The results showed that tasters were significantly more frequent (81,8%) than nontasters (18,2%) in all population. A "higher proportion of nontasters were observed in the quite fat individual group (BMI >= 40kg/m(2)). Alterations explained these differences in basic taste sensitivity, age, gender, BMI, individuals' family obesity situations, vegetarian nourishment. Increased frequency of nontasters allele is evident with obesity condition. This could be due to lack of preference for nutrition among nontasters. So the phenotypic variation in PTC sensitivity is genetic in origin; it may represent an association with obesity, dietary habits, regular weight, gender, and age.

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