48 results on '"Karan, T"'
Search Results
2. Evaluation of Patient-Specific Quality Control (QC) for Markerless Dynamic Tumor Tracking (MDTT) Deliveries
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Camborde, M.L., primary, Karan, T., additional, Horwood, R., additional, Mestrovic, A., additional, and Bergman, A., additional
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- 2023
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3. Magnetic Properties in Multiferroic Bi1−xFe1+xO3 (x ≤ 0.5) of Nanoparticles
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Karan, T., Ram, S., Kotnala, R. K., Giri, P. K., editor, Goswami, D. K., editor, and Perumal, A., editor
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- 2013
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4. Smart Library Management System
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Hiremath, S. G., Karan, T., Vachana, C., Venugopal, M. J., and Naik, Vijeth Vinod
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Automated future ,Radio frequency identification ,Face recognition ,Tags - Abstract
The proposed work Smart Library Management System play a vital role in replacing manual works and errors done by the library staff and students. In the traditional method queues and delays are expected, hence it is a time consuming process. The proposed work is based on RFID and Face Recognition technology, has the ability to recognize and track each and every student and books in the library premise making it the most efficient way which allows fast transaction flow of library activities without much manual intervention. This system will make users to issue and return of books via RFID tags very easy and also calculate the corresponding fine associated with the period of time the absence of the book from the library. This project is a step towards an ‘Automated Future’.
- Published
- 2021
5. Outcome of open necrosectomy versus minimally invasive retroperitoneal necrosectomy following percutaneous drainage in infected necrotising pancreatitis
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Karan, T., primary, Naganath Babu, O.L., additional, Srinivaasan, M., additional, Kolandasamy, C., additional, Prabhakaran, R., additional, and Rajendran, S., additional
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- 2021
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6. Stereotactic Radiation Treatment (SBRT) For Hepatocellular Carcinoma (HCC) Using Dynamic Tumor Tracking (DTT)
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Zhang, T., primary, Dunne, E.M., additional, Bergman, A., additional, Mestrovic, T., additional, Rodgerson, C., additional, Camborde, M.L., additional, Karan, T., additional, Liu, M.C., additional, Schellenberg, D., additional, and Ma, R., additional
- Published
- 2020
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7. Radiographic Changes of Hyperparathyroidism
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Burton Ellis, Karan T. Singh, and Diane Cosner
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medicine.medical_specialty ,Hyperparathyroidism ,business.industry ,Radiography ,medicine ,General Medicine ,Radiology ,business ,medicine.disease - Published
- 2014
8. Challenges in Quality Assurance for Volumetric Radiosurgery of Multiple Brain Metastases
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Karan, T., primary, Duzenli, C.R., additional, Bergman, A., additional, and Vollans, E., additional
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- 2016
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9. Toxicity level of local herbal concoction commonly used in herbal rice preparation by Kelantan Siamese community in Malaysia.
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AWENG, E. R. and KARUNA KARAN, T.
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HERBAL medicine , *DRUG toxicity , *THAI people , *BIOLOGICAL assay - Abstract
Herbal plants have a variety of properties including traditional medicinal value, but the use of herbs in abundance and the mix of some herbs may be harmful to consumers. For Siamese community in Kelantan, Malaysia, they use a mixture of several herbs for the purpose of preparing herbal rice or "nasi kerabu" without knowing the level of toxicity of the herbs. Thus, this study was conducted with the objective of assessing the toxicity level of some herbal formula that was practiced. Plant materials were collected from three Siamese villages; Kampung Pasir Puteh, Kampung Kuang and Kampung Mentua, Kelantan. Three set of concoctions were used for toxicity analysis based on the ratio and amount used from each village. Brine shrimp bioassay was conducted to test toxicity level of the concoction. The results shows that, concoction of Kampung Kuang (VC2) showed the highest mortality rate of 23.33 % at 1000 µg/ml. This was followed by Kampung Pasir Puteh (VC1) with equal nauplii death rate of 16.67 % at 800 µg/ml onwards, meanwhile, Kampung Mentua, (VC3) had 13.33 % death rate at concentration 600 µg/ml onwards. The concoctions studied showed no toxicity effect so that it is safe for consumption. [ABSTRACT FROM AUTHOR]
- Published
- 2018
10. Dynamics of Surface Spins in Small Core–Shell Magnets of Li0.35Zn0.30Fe2.35O4 Bonds over a Carbon Surface and Tailored Magnetic Properties
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Misra, S., primary, Karan, T., additional, and Ram, S., additional
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- 2015
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11. Radiographic Changes of Hyperparathyroidism
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Singh, Karan T., primary, Cosner, Diane, additional, and Ellis, Burton, additional
- Published
- 2014
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12. Dosimetric Discrepancies due to Positional Errors in MLC Movement During Stereotactic Lung VMAT
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Karan, T., primary, Kim, S., additional, Abbas, A., additional, Moseley, D.J., additional, Taremi, M.M., additional, and Yeung, I., additional
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- 2014
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13. Evaluation of 4D Cone Beam Computed Tomography for Target Localization in Stereotactic Body Radiation Therapy for Early Lung Cancer
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Glick, D., primary, Karan, T., additional, Le, K., additional, Allibhai, Z., additional, Taremi, M.M., additional, and Moseley, D.J., additional
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- 2014
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14. Sci-Sat AM: Stereo - 03: Dosmetric evaluation of single versus multi-arc VMAT for lung SBRT
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Karan, T, primary, Taremi, M, additional, Allibhai, Z, additional, Ryan, M, additional, Le, K, additional, and Comsa, D, additional
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- 2014
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15. TH-C-19A-03: Characterization of the Dose Per Pulse Dependence of Various Detectors Used in Quality Assurance of FFF Treatment Plans
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Karan, T, primary, Viel, F, additional, Atwal, P, additional, Gete, E, additional, Camborde, M, additional, Horwood, R, additional, Strgar, V, additional, and Duzenli, C, additional
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- 2014
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16. PO-0798: A study of dose rate dependence of the Ocatavius1000 SRS array for Flattening Filter Free and Flattened photon beams
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Gete, E., primary, Duzenli, C., additional, Karan, T., additional, and Strgar, V., additional
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- 2014
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17. EP-1242: Respiratory-gated radiotherapy in filter-free photon mode for the treatment of liver carcinomas
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Karan, T., primary, Moiseenko, V., additional, and Minchinton, A.I., additional
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- 2013
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18. Radiobiological effects of altering dose rate in filter-free photon beams
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Karan, T, primary, Moiseenko, V, additional, Gill, B, additional, Horwood, R, additional, Kyle, A, additional, and Minchinton, A I, additional
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- 2013
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19. Lattice strain and ferromagnetism in pure and substituted BiFeO[sub 3] samples
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Karan, T., primary and Ram, S., additional
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- 2013
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20. SU‐E‐T‐01: Applications of 6MV FFF Photon Beams in Optimizing Radiobiological Response for Respiratory‐Gated Liver SBRT
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Karan, T, primary, Moiseenko, V, additional, Gill, B, additional, Horwood, R, additional, and Minchinton, A, additional
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- 2012
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21. Magnetic properties of carbon stabilized multiferroic bismuth ferrite nanoparticles
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Karan, T., primary, Ram, S., additional, and Kotnala, R. K., additional
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- 2012
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22. EFFECT OF COPPER ADDITIVES ON IRREVERSIBLE MELTING IN [{(Fe0.5Co0.5)0.75B0.2Si0.05}96Nb4]100-xCux, x ≤ 3, ALLOYS
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KARAN, T., primary, RAM, S., additional, STOICA, M., additional, and ECKERT, J., additional
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- 2011
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23. Magnetic Properties in Multiferroic Bi1-xFe1+xO3 (x ≤ 0.5) of Nanoparticles.
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Karan, T., Ram, S., and Kotnala, R. K.
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- 2013
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24. Dynamics of Surface Spins in Small Core–Shell Magnets of Li0.35Zn0.30Fe2.35O4Bonds over a Carbon Surface and Tailored Magnetic Properties
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Misra, S., Karan, T., and Ram, S.
- Abstract
The lithium zinc ferrite Li0.35Zn0.30Fe2.35O4breeds Fe3+/Fe2+spins via O2–of a network, which is what governs its magnetic and other properties for applications. When the oxygen polygons on the cations bond over an sp2-carbon layer, it keeps small crystallites of sample separated apart in single domains. Cuboids or rectangular prisms (Dc= 25 nm average size) of the ferrite are formed on an inorganic–organic gel, which is burnt in a self-propagating combustion in air. On annealing at ≥400 °C, residual carbon burns out yielding bare ferrite that grows successively; Dc∼ 65 nm in 2 h at 800 °C. Distinct facets grown over plates (crystallites) turn up in a bonded carbon that desorbs off the surface at higher temperatures. At room temperature, a maximum Hc= 81 Oe (Ms= 85.6 emu/g) is shown in ferrite bonds over a thin carbon layer on Dc= 65 nm sample. With Hc= 4 Oe and Ms= 72.2 emu/g, in a virgin sample Dc= 25 nm. At ≥800 °C, a feroxol layer replaces carbon with 1150, 1325, and 1385 cm–1phonon bands. A 7.2% larger Ms= 88.0 emu/g (110.2 emu/g at 4 K) arises over the theoretical value in multidomains (annealed at 1200 °C). Microscopic models brief how a sp2-carbon layer tunes unique features of spin dynamics in a core–shell magnet.
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- 2015
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25. Predictors and Outcome of Admission for Invasive Streptococcus pneumoniae Infections at a Canadian Children's Hospital
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Laupland, K. B., primary, Davies, H. D., additional, Kellner, J. D., additional, Luzod, N.-L., additional, Karan, T., additional, Ma, D., additional, Taub, D., additional, Nijssen-Jordan, C., additional, Katzko, G., additional, Jadavji, T., additional, and Church, D., additional
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- 1998
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26. EFFECT OF COPPER ADDITIVES ON IRREVERSIBLE MELTING IN [{(Fe0.5Co0.5)0.75B0.2Si0.05}96Nb4]100-xCux, x ≤ 3, ALLOYS.
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KARAN, T., RAM, S., STOICA, M., and ECKERT, J.
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IRON alloys , *COPPER , *IRREVERSIBLE processes (Thermodynamics) , *FERROMAGNETISM , *FUSION (Phase transformation) , *SHAPE memory alloys , *GLASS transition temperature , *MAGNETIC properties of metals , *THERMAL properties of metals - Abstract
Iron and cobalt based ferromagnetic bulk amorphous alloys have received considerable interest nowadays in view of their useful properties for wide spread applications in magnet technology, shape memory alloys, high frequency communications at low power loss, and other devices. In this purview, here we report synthesis and thermal properties of bulk amorphous alloys [{(Fe0.5Co0.5)0.75B0.2Si0.05}96Nb4]100-xCux (x = 0, 1, 2, and 3). A copper mould casting of molten alloy was used to obtain a vitrified alloy in form of thin rods (1-2 mm diameter). Amorphous structure retains at a cooling rate as low as 100 K/s in argon atmosphere. Heat out-put measured in terms of a differential scanning calorimetric signal during heating and cooling cycles of these alloys demonstrate irreversibility in a compositional dependent melting point, which follows the glass transition temperature and successive crystallization. The irreversibility persists in this specific example of the bulk amorphous alloys even on sufficiently slow heating or cooling rates such as 0.33 K/s in argon. The copper inclusion tailors the melting point, the enthalpy of the fusion, and other thermodynamic parameters. Results are analyzed in corroboration to the magnetic properties. [ABSTRACT FROM AUTHOR]
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- 2011
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27. Comparative Phytochemical and Biological Evaluation of Different Extracts Obtained from the Leaves of Saraca asoka.
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Debnath, M., Karan, T. K., Pandey, J. N., and Biswas, M.
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MEDICINAL plants , *ANTI-inflammatory agents , *MICE , *CHLOROFORM , *ANALGESICS - Abstract
In the present study, evaluated the analgesic and anti-inflammatory activity of the extracts of Saraca asoka in Swiss albino mice and Wister albino rats respectively. Dried leaves of Saraca asoka were extracted by petroleum ether, chloroform and methanol successively by percolation. The comparative TLC study was also done with these extracts. The extracts had been screened at the dose of 200 mg/kg body weight orally and exhibited significant analgesic and anti-inflammatory properties. [ABSTRACT FROM AUTHOR]
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- 2010
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28. Antitumor effect of dregea volubilis fruit in ehrlich ascites carcinoma bearing mice
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Biswas, M., Bera, S., Kar, B., Karan, T. K., Sanjib Bhattacharya, Ghosh, A. K., and Haldar, P. K.
29. Phenylthiocarbamide taste perception as a possible genetic association marker for nutritional habits and obesity tendency of people
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Dastan, S., NACI DEGERLI, Dastan, T., Yildiz, F., Yildir, Y., Durna, Y. M., Atessahin, D., Karan, T., [Dastan, Sevgi Durna] Cumhuriyet Univ, Fac Vet, Dept Zootech & Anim Nutr, Sivas, Turkey -- [Degerli, Naci] Cumhuriyet Univ, Fac Sci, Dept Mol Biol & Genet, Sivas, Turkey -- [Dastan, Taner] Bingol Univ, Fac Arts & Sci, Dept Chem, Bingol, Turkey -- [Yildiz, Fazilet] Okan Univ, Tuzla Campus Vocat Sch Hlth Serv, Istanbul, Turkey -- [Yildir, Yavuz] Cumhuriyet Univ, Fac Sci, Dept Biol, Sivas, Turkey -- [Durna, Yusuf Muhammed] Istanbul Training & Res Hosp, Dept Otorhinolaryngol, Istanbul, Turkey -- [Atessahin, Dilek] Firat Univ, Fac Arts & Sci, Dept Biol, TR-23169 Elazig, Turkey -- [Karan, Tunay] Gazi Osman Pasa Univ, Fac Arts & Sci, Dept Biol, Tokat, Turkey, and karan, tunay -- 0000-0002-9114-8400
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obesity ,PTC taste sensitivity ,taste genetics ,nontaster PTC trait ,food preference - Abstract
WOS: 000358108900019, PubMed ID: 26051736, Ability to taste Phenylthiocarbamide (PTC) a bitter molecule, is usually used to know the heritable characteristic in both genetic and physiological studies. So far, no research has yet attested whether PTC blindness relation with obesity and some nutrition behaviors of human. This stu.dy is the first attempt on a large scale to examine PTC sensitivity in healthy and overweight people in Turkish population to define in the perception of bitter senses which is associated with nutrition habits, body mass index, age, gender, and to be in stable weight. PTC taste perception was measured by tasting PTC solution filtered in a paper. The results showed that tasters were significantly more frequent (81,8%) than nontasters (18,2%) in all population. A "higher proportion of nontasters were observed in the quite fat individual group (BMI >= 40kg/m(2)). Alterations explained these differences in basic taste sensitivity, age, gender, BMI, individuals' family obesity situations, vegetarian nourishment. Increased frequency of nontasters allele is evident with obesity condition. This could be due to lack of preference for nutrition among nontasters. So the phenotypic variation in PTC sensitivity is genetic in origin; it may represent an association with obesity, dietary habits, regular weight, gender, and age.
30. Antidiabetic and antioxidant activity of Dregea volubilis fruit in streptozotocin-induced diabetic rats
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Biswas, M., Sanjib Bhattacharya, Karan, T. K., Kar, B., Kumar, R. S., Ghosh, A. K., and Haldar, P. K.
31. Hepatoprotective activity of Terminalia arjuna leaf against paracetamol-induced liver damage in rats
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Biswas, M., Karan, T. K., Kar, B., Sanjib Bhattacharya, Ghosh, A. K., Kumar, R. B. S., and Haldar, P. K.
32. Lattice strain and ferromagnetism in pure and substituted BiFeO3 samples.
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Karan, T. and Ram, S.
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IRON ions , *FERROMAGNETISM , *STRAINS & stresses (Mechanics) , *BISMUTH compounds , *CRYSTAL lattices , *COERCIVE fields (Electronics) - Abstract
We report the effect of Fe3+ substitution on the structural and magnetic properties of BiFeO3 samples. The substituted sample (Bi0.5Fe0.5FeO3) is taken into account to compare the results with pure BiFeO3. Both the samples were prepared by a simple self-propagating combustion method at ambient. A decrease in lattice strain as well as crystallite size was observed with substitution. The M-H curve of Bi0.5Fe0.5FeO3 shows an enhanced saturation magnetization with decrease in coercivity and remnance. The experimental results are corroborated with the Fe-O-Fe bond angle and the average A-site cation radius. [ABSTRACT FROM AUTHOR]
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- 2013
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33. Magnetic properties of carbon stabilized multiferroic bismuth ferrite nanoparticles.
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Karan, T., Ram, S., and Kotnala, R. K.
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MAGNETIC properties of nanoparticles , *CARBON , *FERRITES , *NANOPARTICLE synthesis , *COMBUSTION , *ANNEALING of crystals , *TEMPERATURE effect - Abstract
Carbon-stabilized bismuth ferrite (BiFeO3) nanoparticles have been synthesized by a self-combustion method, under ambient conditions and post annealing at selective temperatures between 400-800°C in air. BiFeO3 nanoparticles in carbon matrix show enhanced magnetic properties compared to its bulk counterpart. [ABSTRACT FROM AUTHOR]
- Published
- 2012
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34. Temperature effects explain continental scale distribution of cyanobacterial toxins
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Sigrid Haande, Christos Avagianos, Vítor Gonçalves, Lisette N. de Senerpont Domis, Carlos Rochera, Ana García-Murcia, Kerstin Häggqvist, Reyhan Akçaalan, Jordi Noguero-Ribes, Mariusz Pełechaty, Wojciech Krztoń, Hans-Peter Grossart, Jutta Fastner, Bárbara Úbeda, Wojciech Pęczuła, Nur Filiz, Justyna Kobos, Juan M. Soria, Elif Neyran Soylu, Lars-Anders Hansson, Filip Stević, Luděk Bláha, Hanna Mazur-Marzec, Jolanda M. H. Verspagen, Burçin Önem, Karl-Otto Rothhaupt, Nico Salmaso, Abdulkadir Yağcı, David Parreño Duque, Ksenija Savadova, Nusret Karakaya, Aleksandra Pełechata, Yvon Verstijnen, Carmen Pérez-Martínez, Pauliina Salmi, Gizem Bezirci, Tuğba Ongun Sevindik, Svetislav Krstić, Rahmi Uysal, Laura Seelen, Eloísa Ramos-Rodríguez, Spela Remec-Rekar, Sven Teurlincx, Monserrat Real, Meriç Albay, Donald C. Pierson, Susana Romo, Kristiina Mustonen, Kirsten Christoffersen, Valentini Maliaka, Estela Rodríguez-Pérez, Joanna Rosińska, Nilsun Demir, Mehmet Tahir Alp, Elvira Romans, João Morais, Daniel Szymański, Danielle Machado-Vieira, Damian Chmura, Evanthia Mantzouki, Teresa Vegas-Vilarrúbia, Antonio Picazo, Mikołaj Kokociński, Anastasia Hiskia, Christine Edwards, Yang Yang, Irma Vitonytė, Mehmet Cesur, Agnieszka Bańkowska-Sobczak, Iwona Kostrzewska-Szlakowska, Nikoletta Tsiarta, Anđelka Plenković-Moraj, Miquel Lürling, Ryszard Gołdyn, Kristel Panksep, Kemal Celik, Anna Kozak, Jose Luis Cereijo, Pablo Urrutia-Cordero, Petra M. Visser, Rodan Geriš, Uğur Işkın, Leonardo Cerasino, Kadir Çapkın, Victor C. Perello, Carmen Cillero-Castro, Arda Özen, Manel Leira, Enrique Moreno-Ostos, Şakir Çinar, Agnieszka Budzyńska, Faruk Maraşlıoğlu, Pedro M. Raposeiro, Theodoros M. Triantis, Agnieszka Pasztaleniec, Sevasti-Kiriaki Zervou, Elżbieta Wilk-Woźniak, Edward Walusiak, Kersti Kangro, Jorge Juan Montes-Pérez, Triantafyllos Kaloudis, Mari Carmen Trapote, Pablo Alcaraz-Párraga, José María Blanco, Marek Kruk, Hans W. Paerl, Lidia Nawrocka, Meryem Beklioglu, Antonio Camacho, Moritz Buck, Biel Obrador, Ilona Gagala, Lauri Arvola, Elżbieta Szeląg-Wasielewska, Petar Žutinić, Giovanna Flaim, Núria Catalán, R. Carballeira, Alinne Gurjão de Oliveira, Magdalena Frąk, Alo Laas, Magdalena Grabowska, Dubravka Špoljarić Maronić, Meral Apaydın Yağcı, Itana Bokan Vucelić, Ana Maria Antão-Geraldes, Tõnu Feldmann, Natalia Jakubowska-Krepska, Trine Perlt Warming, Armand Hernández, Anna C. Santamans, Fuat Bilgin, Cayelan C. Carey, Joana Mankiewicz-Boczek, Elísabeth Fernández-Morán, Mete Yilmaz, Iwona Jasser, Boris Aleksovski, Michał Wasilewicz, Agnieszka Ochocka, David García, Lea Tuvikene, Roberto L. Palomino, B.W. Ibelings, Hatice Tunca, Birger Skjelbred, Joan Gomà, Jūratė Karosienė, Maria G. Antoniou, Vitor Vasconcelos, Mehmet Ali Turan Koçer, Eti E. Levi, Markéta Fránková, Beata Madrecka, Barbara Pawlik-Skowrońska, Jeremy Fonvielle, Korhan Özkan, Maciej Karpowicz, Özden Fakioglu, Lucia Chomova, Magdalena Toporowska, Ülkü Nihan Tavşanoğlu, Jūratė Kasperovičienė, Latife Köker, Kinga Kwasizur, Koray Ozhan, Valeriano Rodríguez, William Colom-Montero, Ulrike Obertegger, Micaela Vale, Spyros Gkelis, Michał Niedźwiecki, Tunay Karan, Piotr Domek, Judita Koreivienė, Andrea G. Bravo, Justyna Sieńska, Jessica Richardson, Hana Nemova, Cafer Bulut, Jordi Delgado-Martín, Tanja Žuna Pfeiffer, Marija Gligora Udovič, Manthos Panou, Dietmar Straile, Rafael Marcé, Valerie McCarthy, Iveta Drastichova, Agnieszka Napiórkowska-Krzebietke, J. A. Gálvez, Tina Elersek, Beata Messyasz, Adriano Boscaini, Carmen Ferriol, Julita Dunalska, Freshwater and Marine Ecology (IBED, FNWI), BAİBÜ, Mühendislik Fakültesi, Çevre Mühendisliği Bölümü, Karakaya, Nusret, Universitat de Barcelona, Fakülteler, Fen - Edebiyat Fakültesi, Biyoloji Bölümü, Soylu, Elif Neyran, European Cooperation in Science and Technology, Université de Genève, Tokat Gaziosmanpaşa Üniversitesi, Lammi Biological Station, Doctoral Programme in Atmospheric Sciences, CIIMAR - Centro Interdisciplinar de Investigação Marinha e Ambiental, Yılmaz, Mete, Institute of Agricultural and Environmental Sciences, Mantzouki, Evanthia, Ibelings, Bastiaan Willem, Mantzouki, E, Lurling, M, Fastner, J, Domis, LD, Wilk-Wozniak, E, Koreiviene, J, Seelen, L, Teurlincx, S, Verstijnen, Y, Krzton, W, Walusiak, E, Karosiene, J, Kasperoviciene, J, Savadova, K, Vitonyte, I, Cillero-Castro, C, Budzynska, A, Goldyn, R, Kozak, A, Rosinska, J, Szelag-Wasielewska, E, Domek, P, Jakubowska-Krepska, N, Kwasizur, K, Messyasz, B, Pelechata, A, Pelechaty, M, Kokocinski, M, Garcia-Murcia, A, Real, M, Romans, E, Noguero-Ribes, J, Duque, DP, Fernandez-Moran, E, Karakaya, N, Haggqvist, K, Demir, N, Beklioglu, M, Filiz, N, Levi, EE, Iskin, U, Bezirci, G, Tavsanoglu, UN, Ozhan, K, Gkelis, S, Panou, M, Fakioglu, O, Avagianos, C, Kaloudis, T, Celik, K, Yilmaz, M, Marce, R, Catalan, N, Bravo, AG, Buck, M, Colom-Montero, W, Mustonen, K, Pierson, D, Yang, Y, Raposeiro, PM, Goncalves, V, Antoniou, MG, Tsiarta, N, McCarthy, V, Perello, VC, Feldmann, T, Laas, A, Panksep, K, Tuvikene, L, Gagala, I, Mankiewicz-Boczek, J, Yagci, MA, Cinar, S, Capkin, K, Yagci, A, Cesur, M, Bilgin, F, Bulut, C, Uysal, R, Obertegger, U, Boscaini, A, Flaim, G, Salmaso, N, Cerasino, L, Richardson, J, Visser, PM, Verspagen, JMH, Karan, T, Soylu, EN, Maraslioglu, F, Napiorkowska-Krzebietke, A, Ochocka, A, Pasztaleniec, A, Antao-Geraldes, AM, Vasconcelos, V, Morais, J, Vale, M, Koker, L, Akcaalan, R, Albay, M, Maronic, DS, Stevic, F, Pfeiffer, TZ, Fonvielle, J, Straile, D, Rothhaupt, KO, Hansson, LA, Urrutia-Cordero, P, Blaha, L, Geris, R, Frankova, M, Kocer, MAT, Alp, MT, Remec-Rekar, S, Elersek, T, Triantis, T, Zervou, SK, Hiskia, A, Haande, S, Skjelbred, B, Madrecka, B, Nemova, H, Drastichova, I, Chomova, L, Edwards, C, Sevindik, TO, Tunca, H, Onem, B, Aleksovski, B, Krstic, S, Vucelic, IB, Nawrocka, L, Salmi, P, Machado-Vieira, D, de Oliveira, AG, Delgado-Martin, J, Garcia, D, Cereijo, JL, Goma, J, Trapote, MC, Vegas-Vilarrubia, T, Obrador, B, Grabowska, M, Karpowicz, M, Chmura, D, Ubeda, B, Galvez, JA, Ozen, A, Christoffersen, KS, Warming, TP, Kobos, J, Mazur-Marzec, H, Perez-Martinez, C, Ramos-Rodriguez, E, Arvola, L, Alcaraz-Parraga, P, Toporowska, M, Pawlik-Skowronska, B, Niedzwiecki, M, Peczula, W, Leira, M, Hernandez, A, Moreno-Ostos, E, Blanco, JM, Rodriguez, V, Montes-Perez, JJ, Palomino, RL, Rodriguez-Perez, E, Carballeira, R, Camacho, A, Picazo, A, Rochera, C, Santamans, AC, Ferriol, C, Romo, S, Soria, JM, Dunalska, J, Sienska, J, Szymanski, D, Kruk, M, Kostrzewska-Szlakowska, I, Jasser, I, Zutinic, P, Udovic, MG, Plenkovic-Moraj, A, Frak, M, Bankowska-Sobczak, A, Wasilewicz, M, Ozkan, K, Maliaka, V, Kangro, K, Grossart, HP, Paerl, HW, Carey, CC, Ibelings, BW, Sakarya Üniversitesi/Fen-Edebiyat Fakültesi/Biyoloji Bölümü, Ongun Sevindik, Tuğba, Tunca, Hatice, Hitit Üniversitesi, Fen Edebiyat Fakültesi, Biyoloji Bölümü, and Fen Edebiyat Fakültesi
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light climate ,0106 biological sciences ,thermocline ,Bacterial toxins ,toksiinit ,limit of quantitation ,Toxines bacterianes ,Microcystin-LR ,Toxicology ,01 natural sciences ,Anatoxin-a ,analogs and derivatives ,BLOOMS ,Direct Effects ,uracil ,Water Pollutants ,chemistry.chemical_classification ,Temperatures ,FRESH-WATER ,latitude ,maximum buoyancy frequency ,6. Clean water ,climate change ,Indirect effects ,EUTROPHICATION ,microcystin RR ,articles ,GROWTH ,lämpötila ,LAKES ,microcystin ,anatoxin ,cylindrospermopsin ,temperature ,direct effects ,indirect effects ,spatial distribution ,European Multi Lake Survey ,epilimnetic temperature ,ta1172 ,cyanobacteria, lakes, climate warming, microcystin ,Zoology ,Article ,water pollutant ,MICROCYSTIS-AERUGINOSA ,Alkaloids ,Settore BIO/07 - ECOLOGIA ,NATURAL SCIENCES. Biology ,Spatial distribution ,Microcystis aeruginosa ,Uracil ,lake ,syanobakteerit ,Indirect Effects ,liquid chromatography-mass spectrometry ,1172 Environmental sciences ,Ekologi ,nutrient ,010604 marine biology & hydrobiology ,lcsh:R ,microbiology ,Climatic changes ,microcystin LR ,Anatoxin ,Lakes ,Spatial Distribution ,chemistry ,nodularin ,microbial diversity ,phytoplankton ,ta1181 ,Cylindrospermopsin ,Tropanes ,Cyanobacteria ,Aquatic Ecology and Water Quality Management ,analysis ,Health, Toxicology and Mutagenesis ,lcsh:Medicine ,environmental parameters ,010501 environmental sciences ,medicine.disease_cause ,nitrogen ,chemistry.chemical_compound ,sea surface temperature ,environmental factor ,ddc:550 ,Canvi climàtic ,phosphorus ,PRIRODNE ZNANOSTI. Biologija ,limit of detection ,Ecology ,Cyanobacteria Toxins ,biology ,Temperature ,levinneisyys ,Nodularin ,tropane derivative ,Europe ,DAPHNIA-MAGNA ,İndirect Effects ,Direct effects ,microbial community ,Environmental Monitoring ,high performance liquid chromatography ,Microcystins ,Climate Change ,Bacterial Toxins ,Microcystin ,välittömät oikeusvaikutukset ,cyanobacterium ,ddc:570 ,geographic distribution ,medicine ,bacterial toxin ,controlled study ,ddc:610 ,Institut für Biochemie und Biologie ,0105 earth and related environmental sciences ,nonhuman ,WIMEK ,Toxin ,longitude ,PHYTOPLANKTON ASSEMBLAGES ,Aquatic Ecology ,NITROGEN AVAILABILITY ,anatoxin a ,Aquatische Ecologie en Waterkwaliteitsbeheer ,biology.organism_classification ,Climatic change ,CLIMATE ,13. Climate action ,response variable ,Canvis climàtics - Abstract
Insight into how environmental change determines the production and distribution of cyanobacterial toxins is necessary for risk assessment. Management guidelines currently focus on hepatotoxins (microcystins). Increasing attention is given to other classes, such as neurotoxins (e.g., anatoxin-a) and cytotoxins (e.g., cylindrospermopsin) due to their potency. Most studies examine the relationship between individual toxin variants and environmental factors, such as nutrients, temperature and light. In summer 2015, we collected samples across Europe to investigate the effect of nutrient and temperature gradients on the variability of toxin production at a continental scale. Direct and indirect effects of temperature were the main drivers of the spatial distribution in the toxins produced by the cyanobacterial community, the toxin concentrations and toxin quota. Generalized linear models showed that a Toxin Diversity Index (TDI) increased with latitude, while it decreased with water stability. Increases in TDI were explained through a significant increase in toxin variants such as MC-YR, anatoxin and cylindrospermopsin, accompanied by a decreasing presence of MC-LR. While global warming continues, the direct and indirect effects of increased lake temperatures will drive changes in the distribution of cyanobacterial toxins in Europe, potentially promoting selection of a few highly toxic species or strains. © 2018 by the authors. Licensee MDPI, Basel, Switzerland., The authors acknowledge COST Action ES 1105 “CYANOCOST—Cyanobacterial blooms and toxins in water resources: Occurrence impacts and management” and COST Action ES 1201 “NETLAKE—Networking Lake Observatories in Europe” for contributing to this study through networking and knowledge sharing with European experts in the field. Evanthia Mantzouki was supported by a grant from the Swiss State Secretariat for Education, Research and Innovation (SERI) to Bas Ibelings and by supplementary funding from the University of Geneva. We thank Clare Ahnlund, Ena Suarez and Irene Gallego for helping out with the Swiss survey. We thank Wendy Beekman and Els J. Faassen for the nutrient and toxin analysis.
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- 2018
35. Data Descriptor: A European Multi Lake Survey dataset of environmental variables, phytoplankton pigments and cyanotoxins
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Tunca, Hatice, Mantzouki, E, Campbell, J, van Loon, E, Visser, P, Konstantinou, I, Antoniou, M, Giuliani, G, Machado-Vieira, D, de Oliveira, AG, Maronic, DS, Stevic, F, Pfeiffer, TZ, Vucelic, IB, Zutinic, P, Udovic, MG, Plenkovic-Moraj, A, Tsiarta, N, Blaha, L, Geris, R, Frankova, M, Christoffersen, KS, Warming, TP, Feldmann, T, Laas, A, Panksep, K, Tuvikene, L, Kangro, K, Haggqvist, K, Salmi, P, Arvola, L, Fastner, J, Straile, D, Rothhaupt, KO, Fonvielle, J, Grossart, HP, Avagianos, C, Kaloudis, T, Triantis, T, Zervou, SK, Hiskia, A, Gkelis, S, Panou, M, McCarthy, V, Perello, VC, Obertegger, U, Boscaini, A, Flaim, G, Salmaso, N, Cerasino, L, Koreiviene, J, Karosiene, J, Kasperoviciene, J, Savadova, K, Vitonyte, I, Haande, S, Skjelbred, B, Grabowska, M, Karpowicz, M, Chmura, D, Nawrocka, L, Kobos, J, Mazur-Marzec, H, Alcaraz-Parraga, P, Wilk-Wozniak, E, Krzton, W, Walusiak, E, Gagala, I, Mankiewicz-Boczek, J, Toporowska, M, Pawlik-Skowronska, B, Niedzwiecki, M, Peczula, W, Napiorkowska-Krzebietke, A, Dunalska, J, Sienska, J, Szymanski, D, Kruk, M, Budzynska, A, Goldyn, R, Kozak, A, Rosinska, J, Szelag-Wasielewska, E, Domek, P, Jakubowska-Krepska, N, Kwasizur, K, Messyasz, B, Pelechata, A, Pelechaty, M, Kokocinski, M, Madrecka, B, Kostrzewska-Szlakowska, I, Frak, M, Bankowska-Sobczak, A, Wasilewicz, M, Ochocka, A, Pasztaleniec, A, Jasser, I, Antao-Geraldes, AM, Leira, M, Hernandez, A, Vasconcelos, V, Morais, J, Vale, M, Raposeiro, PM, Goncalves, V, Aleksovski, B, Krstic, S, Nemova, H, Drastichova, I, Chomova, L, Remec-Rekar, S, Elersek, T, Delgado-Martin, J, Garcia, D, Cereijo, JL, Goma, J, Trapote, MC, Vegas-Vilarrubia, T, Obrador, B, Garcia-Murcia, A, Real, M, Romans, E, Noguero-Ribes, J, Duque, DP, Fernandez-Moran, E, Ubeda, B, Galvez, JA, Marce, R, Catalan, N, Perez-Martinez, C, Ramos-Rodriguez, E, Cillero-Castro, C, Moreno-Ostos, E, Blanco, JM, Rodriguez, V, Montes-Perez, JJ, Palomino, RL, Rodriguez-Perez, E, Carballeira, R, Camacho, A, Picazo, A, Rochera, C, Santamans, AC, Ferriol, C, Romo, S, Soria, JM, Hansson, LA, Urrutia-Cordero, P, Ozen, A, Bravo, AG, Buck, M, Colom-Montero, W, Mustonen, K, Pierson, D, Yang, Y, Verspagen, JMH, Domis, LND, Seelen, L, Teurlincx, S, Verstijnen, Y, Lurling, M, Maliaka, V, Faassen, EJ, Latour, D, Carey, CC, Paerl, HW, Torokne, A, Karan, T, Demir, N, Beklioglu, M, Filiz, N, Levi, EE, Iskin, U, Bezirci, G, Tavsanoglu, UN, Celik, K, Ozhan, K, Karakaya, N, Kocer, MAT, Yilmaz, M, Maraslioglu, F, Fakioglu, O, Soylu, EN, Yagci, MA, Cinar, S, Capkin, K, Yagci, A, Cesur, M, Bilgin, F, Bulut, C, Uysal, R, Koker, L, Akcaalan, R, Albay, M, Alp, MT, Ozkan, K, Sevindik, TO, Tunca, H, Onem, B, Richardson, J, Edwards, C, Bergkemper, V, O'Leary, S, Beirne, E, Cromie, H, Ibelings, BW, Sakarya Üniversitesi/Fen-Edebiyat Fakültesi/Biyoloji Bölümü, and Tunca, Hatice
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Science & Technology - Other Topics - Abstract
Under ongoing climate change and increasing anthropogenic activity, which continuously challenge ecosystem resilience, an in-depth understanding of ecological processes is urgently needed. Lakes, as providers of numerous ecosystem services, face multiple stressors that threaten their functioning. Harmful cyanobacterial blooms are a persistent problem resulting from nutrient pollution and climate-change induced stressors, like poor transparency, increased water temperature and enhanced stratification. Consistency in data collection and analysis methods is necessary to achieve fully comparable datasets and for statistical validity, avoiding issues linked to disparate data sources. The European Multi Lake Survey (EMLS) in summer 2015 was an initiative among scientists from 27 countries to collect and analyse lake physical, chemical and biological variables in a fully standardized manner. This database includes in-situ lake variables along with nutrient, pigment and cyanotoxin data of 369 lakes in Europe, which were centrally analysed in dedicated laboratories. Publishing the EMLS methods and dataset might inspire similar initiatives to study across large geographic areas that will contribute to better understanding lake responses in a changing environment.
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- 2018
36. Detection of FLASH-radiotherapy tissue sparing in a 3D-spheroid model using DNA damage response markers.
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Kyle AH, Karan T, Baker JHE, Püspöky Banáth J, Wang T, Liu A, Mendez C, Peter Petric M, Duzenli C, and Minchinton AI
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- Humans, Histones metabolism, Histones analysis, Oxygen Consumption radiation effects, Dose-Response Relationship, Radiation, Organ Sparing Treatments methods, DNA Damage radiation effects, Spheroids, Cellular radiation effects
- Abstract
Purpose: The oxygen depletion hypothesis has been proposed as a rationale to explain the observed phenomenon of FLASH-radiotherapy (FLASH-RT) sparing normal tissues while simultaneously maintaining tumor control. In this study we examined the distribution of DNA Damage Response (DDR) markers in irradiated 3D multicellular spheroids to explore the relationship between FLASH-RT protection and radiolytic-oxygen-consumption (ROC) in tissues., Methods: Studies were performed using a Varian Truebeam linear accelerator delivering 10 MeV electrons with an average dose rate above 50 Gy/s. Irradiations were carried out on 3D spheroids maintained under a range of O
2 and temperature conditions to control O2 consumption and create gradients representative of in vivo tissues., Results: Staining for pDNA-PK (Ser2056) produced a linear radiation dose response whereas γH2AX (Ser139) showed saturation with increasing dose. Using the pDNA-PK staining, radiation response was then characterised for FLASH compared to standard-dose-rates as a function of depth into the spheroids. At 4 °C, chosen to minimize the development of metabolic oxygen gradients within the tissues, FLASH protection could be observed at all distances under oxygen conditions of 0.3-1 % O2 . Whereas at 37 °C a FLASH-protective effect was limited to the outer cell layers of tissues, an effect only observed at 3 % O2 . Modelling of changes in the pDNA-PK-based oxygen enhancement ratio (OER) yielded a tissue ROC g0 -value estimate of 0.73 ± 0.25 µM/Gy with a km of 5.4 µM at FLASH dose rates., Conclusions: DNA damage response markers are sensitive to the effects of transient oxygen depletion during FLASH radiotherapy. Findings support the rationale that well-oxygenated tissues would benefit more from FLASH-dose-rate protection relative to poorly-oxygenated tissues., Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (Crown Copyright © 2024. Published by Elsevier B.V. All rights reserved.)- Published
- 2024
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37. Four-dimensional treatment planning strategies for dynamic tumor tracking.
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Carpentier EE, McDermott RL, Camborde MA, Karan T, Bergman AM, and Mestrovic A
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- Humans, Liver Neoplasms radiotherapy, Liver Neoplasms diagnostic imaging, Respiration, Algorithms, Four-Dimensional Computed Tomography methods, Movement, Radiotherapy Planning, Computer-Assisted methods, Radiotherapy, Intensity-Modulated methods, Radiotherapy Dosage, Organs at Risk radiation effects, Radiosurgery methods
- Abstract
Introduction: Dynamic tumor tracking (DTT) is a motion management technique where the radiation beam follows a moving tumor in real time. Not modelling DTT beam motion in the treatment planning system leaves an organ at risk (OAR) vulnerable to exceeding its dose limit. This work investigates two planning strategies for DTT plans, the "Boolean OAR Method" and the "Aperture Sorting Method," to determine if they can successfully spare an OAR while maintaining sufficient target coverage., Materials and Methods: A step-and-shoot intensity modulated radiation therapy (sIMRT) treatment plan was re-optimized for 10 previously treated liver stereotactic ablative radiotherapy patients who each had one OAR very close to the target. Two planning strategies were investigated to determine which is more effective at sparing an OAR while maintaining target coverage: (1) the "Boolean OAR Method" created a union of an OAR's contours from two breathing phases (exhale and inhale) on the exhale phase (the planning CT) and protected this combined OAR during plan optimization, (2) the "Aperture Sorting Method" assigned apertures to the breathing phase where they contributed the least to an OAR's maximum dose., Results: All 10 OARs exceeded their dose constraints on the original plan four-dimensional (4D) dose distributions and average target coverage was V
100% = 91.3% ± 2.9% (ranging from 85.1% to 94.8%). The "Boolean OAR Method" spared 7/10 OARs, and mean target coverage decreased to V100% = 87.1% ± 3.8% (ranging from 80.7% to 93.7%). The "Aperture Sorting Method" spared 9/10 OARs and the mean target coverage remained high at V100% = 91.7% ± 2.8% (ranging from 84.9% to 94.5%)., Conclusions: 4D planning strategies are simple to implement and can improve OAR sparing during DTT treatments. The "Boolean OAR Method" improved sparing of OARs but target coverage was reduced. The "Aperture Sorting Method" further improved sparing of OARs and maintained target coverage., (© 2024 The Authors. Journal of Applied Clinical Medical Physics published by Wiley Periodicals LLC on behalf of American Association of Physicists in Medicine.)- Published
- 2024
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38. Markerless dynamic tumor tracking (MDTT) radiotherapy using diaphragm as a surrogate for liver targets.
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Rostamzadeh M, Thomas S, Camborde ML, Karan T, Liu M, Ma R, Mestrovic A, Gill B, Tai I, and Bergman A
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- Humans, Liver diagnostic imaging, Motion, Thorax, Phantoms, Imaging, Diaphragm diagnostic imaging, Lung Neoplasms radiotherapy
- Abstract
Purpose: To assess the feasibility of using the diaphragm as a surrogate for liver targets during MDTT., Methods: Diaphragm as surrogate for markers: a dome-shaped phantom with implanted markers was fabricated and underwent dual-orthogonal fluoroscopy sequences on the Vero4DRT linac. Ten patients participated in an IRB-approved, feasibility study to assess the MDTT workflow. All images were analyzed using an in-house program to back-project the diaphragm/markers position to the isocenter plane. ExacTrac imager log files were analyzed. Diaphragm as tracking structure for MDTT: The phantom "diaphragm" was contoured as a markerless tracking structure (MTS) and exported to Vero4DRT/ExacTrac. A single field plan was delivered to the phantom film plane under static and MDTT conditions. In the patient study, the diaphragm tracking structure was contoured on CT breath-hold-exhale datasets. The MDTT workflow was applied until just prior to MV beam-on., Results: Diaphragm as surrogate for markers: phantom data confirmed the in-house 3D back-projection program was functioning as intended. In patients, the diaphragm/marker relative positions had a mean ± RMS difference of 0.70 ± 0.89, 1.08 ± 1.26, and 0.96 ± 1.06 mm in ML, SI, and AP directions. Diaphragm as tracking structure for MDTT: Building a respiratory-correlation model using the diaphragm as surrogate for the implanted markers was successful in phantom/patients. During the tracking verification imaging step, the phantom mean ± SD difference between the image-detected and predicted "diaphragm" position was 0.52 ± 0.18 mm. The 2D film gamma (2%/2 mm) comparison (static to MDTT deliveries) was 98.2%. In patients, the mean difference between the image-detected and predicted diaphragm position was 2.02 ± 0.92 mm. The planning target margin contribution from MDTT diaphragm tracking is 2.2, 5.0, and 4.7 mm in the ML, SI, and AP directions., Conclusion: In phantom/patients, the diaphragm motion correlated well with markers' motion and could be used as a surrogate. MDTT workflows using the diaphragm as the MTS is feasible using the Vero4DRT linac and could replace the need for implanted markers for liver radiotherapy., (© 2023 The Authors. Journal of Applied Clinical Medical Physics published by Wiley Periodicals LLC on behalf of American Association of Physicists in Medicine.)
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- 2024
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39. In-vivo quality assurance of dynamic tumor tracking (DTT) for liver SABR using EPID images.
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Rostamzadeh M, Luchka K, Ma R, Liu M, Dunne E, Camborde ML, Karan T, Mestrovic A, and Bergman A
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- Humans, Radiometry methods, Phantoms, Imaging, Liver diagnostic imaging, Liver surgery, Radiotherapy Planning, Computer-Assisted methods, Radiotherapy Dosage, Radiotherapy, Conformal methods, Neoplasms, Radiosurgery
- Abstract
Purpose: To assess dynamic tumor tracking (DTT) target localization uncertainty for in-vivo marker-based stereotactic ablative radiotherapy (SABR) treatments of the liver using electronic-portal-imaging-device (EPID) images. The Planning Target Volume (PTV) margin contribution for DTT is estimated., Methods: Phantom and patient EPID images were acquired during non-coplanar 3DCRT-DTT delivered on a Vero4DRT linac. A chain-code algorithm was applied to detect Multileaf Collimator (MLC)-defined radiation field edges. Gold-seed markers were detected using a connected neighbor algorithm. For each EPID image, the absolute differences between the measured center-of-mass (COM) of the markers relative to the aperture-center (Tracking Error, (E
T )) was reported in pan, tilt, and 2D-vector directions at the isocenter-plane., Phantom Study: An acrylic cube phantom implanted with gold-seed markers was irradiated with non-coplanar 3DCRT-DTT beams and EPID images collected. Patient Study: Eight liver SABR patients were treated with non-coplanar 3DCRT-DTT beams. All patients had three to four implanted gold-markers. In-vivo EPID images were analyzed., Results: Phantom Study: On the 125 EPID images collected, 100% of the markers were identified. The average ± SD of ET were 0.24 ± 0.21, 0.47 ± 0.38, and 0.58 ± 0.37 mm in pan, tilt and 2D directions, respectively. Patient Study: Of the 1430 EPID patient images acquired, 78% had detectable markers. Over all patients, the average ± SD of ET was 0.33 ± 0.41 mm in pan, 0.63 ± 0.75 mm in tilt and 0.77 ± 0.80 mm in 2D directions The random 2D-error, σ, for all patients was 0.79 mm and the systematic 2D-error, Σ, was 0.20 mm. Using the Van Herk margin formula 1.1 mm planning target margin can represent the marker based DTT uncertainty., Conclusions: Marker-based DTT uncertainty can be evaluated in-vivo on a field-by-field basis using EPID images. This information can contribute to PTV margin calculations for DTT., (© 2023 The Authors. Journal of Applied Clinical Medical Physics published by Wiley Periodicals, LLC on behalf of The American Association of Physicists in Medicine.)- Published
- 2023
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40. Synthesis and characterization of silver nanoparticles using curcumin: cytotoxic, apoptotic, and necrotic effects on various cell lines.
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Karan T, Erenler R, and Moran Bozer B
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- Anti-Bacterial Agents pharmacology, Cell Line, Plant Extracts chemistry, Silver chemistry, Antineoplastic Agents chemistry, Curcumin pharmacology, Metal Nanoparticles chemistry
- Abstract
Nanostructures have distinctive chemical and physical features owing to their surface area and nanoscale size. In this study, silver nanoparticles were synthesized using curcumin, a medicinally valuable natural product. The structure of curcumin-mediated silver nanoparticles (c-AgNPs) was identified by extensive spectroscopic techniques. The maximum absorption was observed at 430 nm in UV-Vis spectrum. The crystal structure of c-AgNPs was identified by XRD. The morphology of the structure was determined by SEM image. The particle size was found as 51.13 nm. The functional groups of curcumin and c-AgNPs were established by FTIR spectroscopy. Cytotoxic activity of c-AgNPs was carried out using A549, DLD-1, and L929 with MTT assay. c-AgNPs revealed excellent activity on DLD-1 cell lines and A549 cell lines at 1.0 mg/mL concentration with the lethal effect of 80%. However, nanoparticles did not show the considerable effect on L929. Moreover, they induced apoptosis. Consequently, c-AgNPs are a promising material for anticancer drugs candidate., (© 2022 Walter de Gruyter GmbH, Berlin/Boston.)
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- 2022
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41. Four-dimensional dose calculations for dynamic tumour tracking with a gimbal-mounted linear accelerator.
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Carpentier EE, McDermott RL, Dunne EM, Camborde MA, Bergman AM, Karan T, Liu MCC, Ma RMK, and Mestrovic A
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- Four-Dimensional Computed Tomography, Humans, Particle Accelerators, Radiotherapy Dosage, Radiotherapy Planning, Computer-Assisted, Respiration, Lung Neoplasms, Neoplasms
- Abstract
Purpose: In this study we present a novel method for re-calculating a treatment plan on different respiratory phases by accurately modeling the panning and tilting beam motion during DTT (the "rotation method"). This method is used to re-calculate the dose distribution of a plan on multiple breathing phases to accurately assess the dosimetry., Methods: sIMRT plans were optimized on a breath hold computed tomography (CT) image taken at exhale (BH
exhale ) for 10 previous liver stereotactic ablative radiotherapy patients. Our method was used to re-calculate the plan on the inhale (0%) and exhale (50%) phases of the four-dimensional CT (4DCT) image set. The dose distributions were deformed to the BHexhale CT and summed together with proper weighting calculated from the patient's breathing trace. Subsequently, the plan was re-calculated on all ten phases using our method and the dose distributions were deformed to the BHexhale CT and accumulated together. The maximum dose for certain organs at risk (OARs) was compared between calculating on two phases and all ten phases., Results: In total, 26 OARs were examined from 10 patients. When the dose was calculated on the inhale and exhale phases six OARs exceeded their dose limit, and when all 10 phases were used five OARs exceeded their limit., Conclusion: Dynamic tumor tracking plans optimized for a single respiratory phase leave an OAR vulnerable to exceeding its dose constraint during other respiratory phases. The rotation method accurately models the beam's geometry. Using deformable image registration to accumulate dose from all 10 breathing phases provides the most accurate results, however it is a time consuming procedure. Accumulating the dose from two extreme breathing phases (exhale and inhale) and weighting them properly provides accurate results while requiring less time. This approach should be used to confirm the safety of a DTT treatment plan prior to delivery., (© 2021 The Authors. Journal of Applied Clinical Medical Physics published by Wiley Periodicals LLC on behalf of American Association of Physicists in Medicine.)- Published
- 2021
- Full Text
- View/download PDF
42. Dosimetry with a clinical linac adapted to FLASH electron beams.
- Author
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Szpala S, Huang V, Zhao Y, Kyle A, Minchinton A, Karan T, and Kohli K
- Subjects
- Film Dosimetry, Humans, Radiometry, Reproducibility of Results, Electrons, Particle Accelerators
- Abstract
Purpose: To assess dosimetric properties and identify required updates to commonly used protocols (including use of film and ionization chamber) pertaining to a clinical linac configured into FLASH (ultra-high dose rate) electron mode., Methods: An 18MV photon beam of a Varian iX linac was converted to FLASH electron beam by replacing the target and the flattening filter with an electron scattering foil. The dose was prescribed by entering the MUs through the console. Fundamental beam properties, including energy, dose rate, dose reproducibility, field size, and dose rate dependence on the SAD, were examined in preparation for radiobiological experiments. Gafchromic EBT-XD film was evaluated for usability in measurements at ultra-high dose rates by comparing the measured dose to the inverse square model. Selected previously reported models of chamber efficiencies were fitted to measurements in a broad range of dose rates., Results: The performance of the modified linac was found adequate for FLASH radiobiological experiments. With exception of the increase in the dose per MU on increase in the repetition rate, all fundamental beam properties proved to be in line with expectations developed with conventional linacs. The field size followed the theorem of similar triangles. The highest average dose rate (2 × 10
4 Gy/s) was found next to the internal monitor chamber, with the field size of FWHM = 1.5 cm. Independence of the dose readings on the dose rate (up to 2 × 104 Gy/s) was demonstrated for the EBT-XD film. A model of recombination in an ionization chamber was identified that provided good agreement with the measured chamber efficiencies for the average dose rates up to at least 2 × 103 Gy/s., Conclusion: Dosimetric measurements were performed to characterize a linac converted to FLASH dose rates. Gafchromic EBT-XD film and dose rate-corrected cc13 ionization chamber were demonstrated usable at FLASH dose rates., (© 2021 The Authors. Journal of Applied Clinical Medical Physics published by Wiley Periodicals LLC on behalf of American Association of Physicists in Medicine.)- Published
- 2021
- Full Text
- View/download PDF
43. Metabolic profile and biological activities of Lavandula stoechas L.
- Author
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Karan T
- Subjects
- Animals, Antioxidants pharmacology, Coleoptera drug effects, Insecticides toxicity, Oils, Volatile chemistry, Plant Extracts pharmacology, Reference Standards, Lavandula metabolism, Metabolome
- Abstract
Medicinal and aromatic plants play a significant role in drug discovery. Lavandula stoechas L. has been used as folk medicine to treat various diseases. The aim of this work is to investigate the phytochemisty of Lavandula stoechas with biological activities. An aerial part of the plant was extracted with methanol. Another sample of plant was boiled in water then aqueous part was extracted with ethyl acetate. Identification and quantification of phenolic compounds, organic acids and flavonoids in methanol extract were carried out by High Performance Liquid Chromatography/Time of Flight/Mass Spectrometry, HPLC-TOF/MS. Rosmarinic acid was found as a chief compound (80.9%). The essential oil was generated by steam distillation and identified by GC-MS. The main constituents were camphor (48.1%) and fenchone (30.5%). The essential oil exhibited good insecticidal activity on Sitophilus granarius and Sitophilus oryzae pests as 43.3% and 62.9% mortality, respectively. However, the methanol extract has only insecticidal activity against S. granaries (50.0%). The antioxidant activities were investigated using assays of 1,1-diphenyl-2-picrylhydrazyl (DPPH•) radical scavenging, reducing power (FRAP), and 2,2'-azinobis-(3-ethylbenzothiazoline-6-sulphonate) (ABTS•+) radical scavenging on both extracts. In addition, total phenolic contents were determined. Total phenolic content of EtOAc extract was found as 2.18 g GAE (Gallic acid equivalent) phenolic compounds/kg plant. Whereas, total phenolic of methanol was 3.33 g GAE/kg plant. EtOAc extract revealed the considerable DPPH• scavenging, ABTS•+ scavenging and reducing power activities with the values of 28.71 (IC50, µg/ml), 8.72 (IC50, µg/ml) and 6.99 (µmol trolox equivalent/mg extract) respectively.
- Published
- 2018
44. A European Multi Lake Survey dataset of environmental variables, phytoplankton pigments and cyanotoxins.
- Author
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Mantzouki E, Campbell J, van Loon E, Visser P, Konstantinou I, Antoniou M, Giuliani G, Machado-Vieira D, Gurjão de Oliveira A, Maronić DŠ, Stević F, Pfeiffer TŽ, Vucelić IB, Žutinić P, Udovič MG, Plenković-Moraj A, Tsiarta N, Bláha L, Geriš R, Fránková M, Christoffersen KS, Warming TP, Feldmann T, Laas A, Panksep K, Tuvikene L, Kangro K, Häggqvist K, Salmi P, Arvola L, Fastner J, Straile D, Rothhaupt KO, Fonvielle J, Grossart HP, Avagianos C, Kaloudis T, Triantis T, Zervou SK, Hiskia A, Gkelis S, Panou M, McCarthy V, Perello VC, Obertegger U, Boscaini A, Flaim G, Salmaso N, Cerasino L, Koreivienė J, Karosienė J, Kasperovičienė J, Savadova K, Vitonytė I, Haande S, Skjelbred B, Grabowska M, Karpowicz M, Chmura D, Nawrocka L, Kobos J, Mazur-Marzec H, Alcaraz-Párraga P, Wilk-Woźniak E, Krztoń W, Walusiak E, Gagala I, Mankiewicz-Boczek J, Toporowska M, Pawlik-Skowronska B, Niedźwiecki M, Pęczuła W, Napiórkowska-Krzebietke A, Dunalska J, Sieńska J, Szymański D, Kruk M, Budzyńska A, Goldyn R, Kozak A, Rosińska J, Szeląg-Wasielewska E, Domek P, Jakubowska-Krepska N, Kwasizur K, Messyasz B, Pełechata A, Pełechaty M, Kokocinski M, Madrecka B, Kostrzewska-Szlakowska I, Frąk M, Bańkowska-Sobczak A, Wasilewicz M, Ochocka A, Pasztaleniec A, Jasser I, Antão-Geraldes AM, Leira M, Hernández A, Vasconcelos V, Morais J, Vale M, Raposeiro PM, Gonçalves V, Aleksovski B, Krstić S, Nemova H, Drastichova I, Chomova L, Remec-Rekar S, Elersek T, Delgado-Martín J, García D, Cereijo JL, Gomà J, Trapote MC, Vegas-Vilarrúbia T, Obrador B, García-Murcia A, Real M, Romans E, Noguero-Ribes J, Duque DP, Fernández-Morán E, Úbeda B, Gálvez JÁ, Marcé R, Catalán N, Pérez-Martínez C, Ramos-Rodríguez E, Cillero-Castro C, Moreno-Ostos E, Blanco JM, Rodríguez V, Montes-Pérez JJ, Palomino RL, Rodríguez-Pérez E, Carballeira R, Camacho A, Picazo A, Rochera C, Santamans AC, Ferriol C, Romo S, Soria JM, Hansson LA, Urrutia-Cordero P, Özen A, Bravo AG, Buck M, Colom-Montero W, Mustonen K, Pierson D, Yang Y, M H Verspagen J, de Senerpont Domis LN, Seelen L, Teurlincx S, Verstijnen Y, Lürling M, Maliaka V, Faassen EJ, Latour D, Carey CC, W Paerl H, Torokne A, Karan T, Demir N, Beklioğlu M, Filiz N, E Levi E, Iskin U, Bezirci G, Tavşanoğlu ÜN, Çelik K, Özhan K, Karakaya N, Koçer MAT, Yilmaz M, Maraşlıoğlu F, Fakioglu Ö, Soylu EN, Yağcı MA, Çınar Ş, Çapkın K, Yağcı A, Cesur M, Bilgin F, Bulut C, Uysal R, Köker L, Akçaalan R, Albay M, Alp MT, Özkan K, Sevindik TO, Tunca H, Önem B, Richardson J, Edwards C, Bergkemper V, O'Leary S, Beirne E, Cromie H, and Ibelings BW
- Subjects
- Climate Change, Europe, Phytoplankton chemistry, Pigments, Biological, Cyanobacteria chemistry, Environmental Monitoring, Lakes
- Abstract
Under ongoing climate change and increasing anthropogenic activity, which continuously challenge ecosystem resilience, an in-depth understanding of ecological processes is urgently needed. Lakes, as providers of numerous ecosystem services, face multiple stressors that threaten their functioning. Harmful cyanobacterial blooms are a persistent problem resulting from nutrient pollution and climate-change induced stressors, like poor transparency, increased water temperature and enhanced stratification. Consistency in data collection and analysis methods is necessary to achieve fully comparable datasets and for statistical validity, avoiding issues linked to disparate data sources. The European Multi Lake Survey (EMLS) in summer 2015 was an initiative among scientists from 27 countries to collect and analyse lake physical, chemical and biological variables in a fully standardized manner. This database includes in-situ lake variables along with nutrient, pigment and cyanotoxin data of 369 lakes in Europe, which were centrally analysed in dedicated laboratories. Publishing the EMLS methods and dataset might inspire similar initiatives to study across large geographic areas that will contribute to better understanding lake responses in a changing environment.
- Published
- 2018
- Full Text
- View/download PDF
45. Temperature Effects Explain Continental Scale Distribution of Cyanobacterial Toxins.
- Author
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Mantzouki E, Lürling M, Fastner J, de Senerpont Domis L, Wilk-Woźniak E, Koreivienė J, Seelen L, Teurlincx S, Verstijnen Y, Krztoń W, Walusiak E, Karosienė J, Kasperovičienė J, Savadova K, Vitonytė I, Cillero-Castro C, Budzyńska A, Goldyn R, Kozak A, Rosińska J, Szeląg-Wasielewska E, Domek P, Jakubowska-Krepska N, Kwasizur K, Messyasz B, Pełechaty A, Pełechaty M, Kokocinski M, García-Murcia A, Real M, Romans E, Noguero-Ribes J, Duque DP, Fernández-Morán E, Karakaya N, Häggqvist K, Demir N, Beklioğlu M, Filiz N, Levi EE, Iskin U, Bezirci G, Tavşanoğlu ÜN, Özhan K, Gkelis S, Panou M, Fakioglu Ö, Avagianos C, Kaloudis T, Çelik K, Yilmaz M, Marcé R, Catalán N, Bravo AG, Buck M, Colom-Montero W, Mustonen K, Pierson D, Yang Y, Raposeiro PM, Gonçalves V, Antoniou MG, Tsiarta N, McCarthy V, Perello VC, Feldmann T, Laas A, Panksep K, Tuvikene L, Gagala I, Mankiewicz-Boczek J, Yağcı MA, Çınar Ş, Çapkın K, Yağcı A, Cesur M, Bilgin F, Bulut C, Uysal R, Obertegger U, Boscaini A, Flaim G, Salmaso N, Cerasino L, Richardson J, Visser PM, Verspagen JMH, Karan T, Soylu EN, Maraşlıoğlu F, Napiórkowska-Krzebietke A, Ochocka A, Pasztaleniec A, Antão-Geraldes AM, Vasconcelos V, Morais J, Vale M, Köker L, Akçaalan R, Albay M, Špoljarić Maronić D, Stević F, Žuna Pfeiffer T, Fonvielle J, Straile D, Rothhaupt KO, Hansson LA, Urrutia-Cordero P, Bláha L, Geriš R, Fránková M, Koçer MAT, Alp MT, Remec-Rekar S, Elersek T, Triantis T, Zervou SK, Hiskia A, Haande S, Skjelbred B, Madrecka B, Nemova H, Drastichova I, Chomova L, Edwards C, Sevindik TO, Tunca H, Önem B, Aleksovski B, Krstić S, Vucelić IB, Nawrocka L, Salmi P, Machado-Vieira D, de Oliveira AG, Delgado-Martín J, García D, Cereijo JL, Gomà J, Trapote MC, Vegas-Vilarrúbia T, Obrador B, Grabowska M, Karpowicz M, Chmura D, Úbeda B, Gálvez JÁ, Özen A, Christoffersen KS, Warming TP, Kobos J, Mazur-Marzec H, Pérez-Martínez C, Ramos-Rodríguez E, Arvola L, Alcaraz-Párraga P, Toporowska M, Pawlik-Skowronska B, Niedźwiecki M, Pęczuła W, Leira M, Hernández A, Moreno-Ostos E, Blanco JM, Rodríguez V, Montes-Pérez JJ, Palomino RL, Rodríguez-Pérez E, Carballeira R, Camacho A, Picazo A, Rochera C, Santamans AC, Ferriol C, Romo S, Soria JM, Dunalska J, Sieńska J, Szymański D, Kruk M, Kostrzewska-Szlakowska I, Jasser I, Žutinić P, Gligora Udovič M, Plenković-Moraj A, Frąk M, Bańkowska-Sobczak A, Wasilewicz M, Özkan K, Maliaka V, Kangro K, Grossart HP, Paerl HW, Carey CC, and Ibelings BW
- Subjects
- Alkaloids, Climate Change, Cyanobacteria Toxins, Environmental Monitoring, Europe, Temperature, Uracil analysis, Bacterial Toxins analysis, Cyanobacteria, Lakes microbiology, Microcystins analysis, Tropanes analysis, Uracil analogs & derivatives, Water Pollutants analysis
- Abstract
Insight into how environmental change determines the production and distribution of cyanobacterial toxins is necessary for risk assessment. Management guidelines currently focus on hepatotoxins (microcystins). Increasing attention is given to other classes, such as neurotoxins (e.g., anatoxin-a) and cytotoxins (e.g., cylindrospermopsin) due to their potency. Most studies examine the relationship between individual toxin variants and environmental factors, such as nutrients, temperature and light. In summer 2015, we collected samples across Europe to investigate the effect of nutrient and temperature gradients on the variability of toxin production at a continental scale. Direct and indirect effects of temperature were the main drivers of the spatial distribution in the toxins produced by the cyanobacterial community, the toxin concentrations and toxin quota. Generalized linear models showed that a Toxin Diversity Index (TDI) increased with latitude, while it decreased with water stability. Increases in TDI were explained through a significant increase in toxin variants such as MC-YR, anatoxin and cylindrospermopsin, accompanied by a decreasing presence of MC-LR. While global warming continues, the direct and indirect effects of increased lake temperatures will drive changes in the distribution of cyanobacterial toxins in Europe, potentially promoting selection of a few highly toxic species or strains., Competing Interests: The authors declare no conflict of interest.
- Published
- 2018
- Full Text
- View/download PDF
46. Screening of Norharmane from Seven Cyanobacteria by High-performance Liquid Chromatography.
- Author
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Karan T and Erenler R
- Abstract
Background: Cyanobacteria, including pharmaceutically and medicinally valuable compounds attract the great attention lately. Norharmane (9H-pyrido (3,4-b) indole found in some cyanobacteria revealed a great number of biological effects., Objective: Seven cyanobacteria were isolated and identified from Yesilirmak River and Gaziosmanpasa University Campus to determine the norharmane content., Materials and Methods: Cyanobacteria collected from Tokat, Turkey were isolated and identified by morphologically. Norharmane (9H-pyrido [3,4-b] indole) quantities were presented for seven cyanobacteria, Chroococcus minutus (Kütz.) Nägeli, Geitlerinema carotinosum (Geitler) Anagnostidis, Nostoc linckia Bornet ex Bornet and Flahault, Anabaena oryzae F. E. Fritsch, Oscillatoria limnetica Lemmermann, Phormidium sp . Kützing ex Gomont, and Cylindrospermum sp . Kutzing ex E. Bornet and C. Flahault by high-performance liquid chromatography., Results: The norharmane amount indicated for cyanobacterial culture media altered in a species-dependent kind in the range of 0.81-10.87 μg/g. C. minutus produced the most norharmane among the investigated cyanobacteria as 10.87 μg/g., Conclusion: Cyanobacteria could be an important source of norharmane as well as pharmaceutically valuable compounds., Summary: Seven cyanobacteria were isolated and identified from Yesilirmak RiverQuantitative analysis of norharmane was executed on isolated cyanobacteriaFour cyanobecteria species included the norharmane Chroococcus minutus contained the most norharmane (10.87 μg/g). Abbreviations used: HPLC: High performance liquid chromatograph., Competing Interests: There are no conflicts of interest.
- Published
- 2017
- Full Text
- View/download PDF
47. Phenylthiocarbamide taste perception as a possible genetic association marker for nutritional habits and obesity tendency of people.
- Author
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Dastan S, Degerli N, Dastan T, Yildiz F, Yildir Y, Durna YM, Atessahin D, and Karan T
- Subjects
- Adolescent, Adult, Age Factors, Aged, Body Mass Index, Female, Genetic Association Studies, Genetic Markers, Genetic Predisposition to Disease, Humans, Male, Middle Aged, Nutritional Status genetics, Obesity physiopathology, Obesity psychology, Phenotype, Risk Factors, Sex Factors, Turkey, Weight Gain genetics, Young Adult, Feeding Behavior, Obesity genetics, Phenylthiourea administration & dosage, Taste Perception genetics
- Abstract
Ability to taste Phenylthiocarbamide (PTC) a bitter molecule, is usually used to know the heritable characteristic in both genetic and physiological studies. So far, no research has yet attested whether PTC blindness relation with obesity and some nutrition behaviors of human. This study is the first attempt on a large scale to examine PTC sensitivity in healthy and overweight people in Turkish population to define in the perception of bitter senses which is associated with nutrition habits, body mass index, age, gender, and to be in stable weight. PTC taste perception was measured by tasting PTC solution filtered in a paper. The results showed that tasters were significantly more frequent (81,8%) than nontasters (18,2%) in all population. A higher proportion of nontasters were observed in the quite fat individual group (BMI >40kg/m(2)). Alterations explained these differences in basic taste sensitivity, age, gender, BMI, individuals' family obesity situations, vegetarian nourishment. Increased frequency of nontasters allele is evident with obesity condition. This could be due to lack of preference for nutrition among nontasters. So the phenotypic variation in PTC sensitivity is genetic in origin; it may represent an association with obesity, dietary habits, regular weight, gender, and age.
- Published
- 2015
48. Relationship between sex roles and mental disorders.
- Author
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Karan TK
- Subjects
- Adult, Female, Humans, India epidemiology, Male, Patient Admission statistics & numerical data, Women's Health, Gender Identity, Men psychology, Mental Disorders epidemiology, Mental Disorders psychology, Women psychology
- Abstract
The present study "Relationship between sex roles and mental disorders" analyses the various findings of research regarding the sex roles and mental problems. All these findings reveal that the women whether they work outside or not, face various mental problems especially functional psychosis and neurosis. This finding is also proved by the research of National Institute of Mental Health (NIMH) of U.S.A. They analysed the admissions and the treatment give for the psychologically affected persons in various hospitals and came across more women patients than the men. The research also formulates some possible suggestions to curb the mental disorders among the women.
- Published
- 1999
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