46 results on '"Karampinis E"'
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2. Numerical investigation Greek lignite/cardoon co-firing in a tangentially fired furnace
- Author
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Karampinis, E., Nikolopoulos, N., Nikolopoulos, A., Grammelis, P., and Kakaras, E.
- Published
- 2012
- Full Text
- View/download PDF
3. Biomass-Derived Solutions for the Decarbonisation of the European Steel, Ceramics and Glass Sectors
- Author
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Carmona, A., Rueda, A., Fresneda, A., Karampinis, E., Lympeti, A., Grammelis, P., and Bolea, I.
- Subjects
Biomass - Abstract
The European Union (EU) has set ambitious targets for the decarbonization of its activities by 2050. The path for the decarbonization has specially focused on the emissions generated by energy intensive industries (EII).These are known to contribute to a third of the total greenhouse gas (GHG) emissions. In the current contribution three relevant industrial sectors are analyzed: ceramics, glass and steel. A common strategy has been followed for the assessment. Special attention has been focused on the energy requirements, GHG emissions, current overall production process employed, circular economy initiatives, brief description of successful cases of energetic biomass implementation, I+D alternatives for decarbonization and barriers to overcome., Proceedings of the 30th European Biomass Conference and Exhibition, 9-12 May 2022, Online, pp. 481-487
- Published
- 2022
- Full Text
- View/download PDF
4. Integrated Harvesting and Biomass Haulage of Olive Tree Prunings. Evaluation of a Two Year Harvesting Campaign in Central Greece
- Author
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Kougioumtzis, M. A., Karampinis, E., Panagiotis Grammelis, and Kakaras, E.
- Subjects
Biomass - Abstract
The aim of the present paper is to evaluate the most intensive demonstration of harvesting of olive tree prunings (OTP) ever occurred in Greece. In Agios Konstantinos, an integrated mulcher was used to harvest the local olive groves. The harvesting campaign was performed for two consecutive years. In total, for both years, the harvesting campaign lasted for 20 days where around 81 ha of olive groves were harvested, that amounted to 252 dry tons of harvested prunings. The aim of the paper is to evaluate an agricultural residue mobilization value chain in terms of performance, economics and fuel analyses of the harvested OTP. Via detailed monitoring, the present paper compares the harvesting demonstration results for both years. In brief, the average harvesting efficiency increased from 2.2 dry tons/hr (first year) to 2.4 dry tons/ hour (second year), whereas the corresponding harvesting and haulage costs of these harvesting campaigns were calculated at 61.8 €/ dry ton and 63.5 €/ dry ton, with an estimated commercial operation cost at 45.7 €/ dry ton. Finally, from 49 samples of OTP collected, the average moisture content was at 27.5% a.r., ash content at 4.5 % d.b. and the average HHV at 19.7 MJ/kg d.b.., Proceedings of the 29th European Biomass Conference and Exhibition, 26-29 April 2021, Online, pp. 69-76
- Published
- 2021
- Full Text
- View/download PDF
5. From agroindustries to integrated biomass logistics centres. Agroinlog project: Summary of final results
- Author
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Gómez, M., Zapata, S., Izquierdo, M., Jarauta-Córdoba, C., Annevelink, E., Snels, J., Urciuoli, L., Kougioumtzis, M.A., Karampinis, E., Grammelis, P., Gunnarsson, C., Lund, J., Pari, L., Suardi, A., Serrat, C., Boukis, I., Karlsson Boll, D., Gustafsson, T., Fernández, P., Rivera, S., Stavropoulou, C., Sanchez Falcon, B., Kravchenko, A., Stojiljković, Dragoslava, Bartolomé, C., Gómez, M., Zapata, S., Izquierdo, M., Jarauta-Córdoba, C., Annevelink, E., Snels, J., Urciuoli, L., Kougioumtzis, M.A., Karampinis, E., Grammelis, P., Gunnarsson, C., Lund, J., Pari, L., Suardi, A., Serrat, C., Boukis, I., Karlsson Boll, D., Gustafsson, T., Fernández, P., Rivera, S., Stavropoulou, C., Sanchez Falcon, B., Kravchenko, A., Stojiljković, Dragoslava, and Bartolomé, C.
- Abstract
AGROinLOG project has tested the integrated biomass logistics centres (IBLC) concept in three real agro-industries in Europe. The relevance of the IBLC strategy relies on the fact that it allows agro-industries to create a new activity with lower investment, increasing incomes, stabilizing their annual activity (avoiding idle periods) and maintaining or creating new jobs. The demos’ studies were performed in Spain at a fodder industry, in Greece at an olive oil industry, and in Sweden inside a cereal processing industry. AGROinLOG validated these demos´ business models from a holistic perspective, also studying the replicability of the IBLC business model in other agro-industries from different sectors (vegetable oil extraction, olive oil chain, feed & fodder, wine, grain chain and sugar industry). Sectorial analysis was carried out as well, allowing the identification of opportunities among the targeted sector to replicate the IBLC concept, drawing barriers to overcome in each case. Thus, technical, economic and environmental feasibility of integrated biomass logistics centers (IBLCs) for food and non-food products have been assessed in detail.
- Published
- 2020
6. AgroBioHeat: Promoting Modern Agrobiomass Heating Solutions in Rural Europe
- Author
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Karampinis, E., Kanaveli, I.P., Grammelis, P.
- Published
- 2019
- Full Text
- View/download PDF
7. 'Mediterranean' Solid Biofuels from Agro-Industrial Residues in Greece: Market Status and Prospectives for the Domestic Heating Sector
- Author
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Karampinis, E., Kougioumtzis, M. -A, Panagiotis Grammelis, and Kakaras, E.
- Subjects
Biomass - Abstract
The biomass use in the domestic heating sector in Greece has undergone an expansion since 2011, mostly due to two factors: the financial crisis and the increased taxation of heating oil on the one hand, and the lifting of the ban to biomass combustion in large urban areas. More than 80 % of the bioenergy consumption in Greece is coming from the residential sector and biomass is the RES with the highest contribution to the national primary energy consumption. However, the per capita consumption of solid biofuels is still one of the lowest in the EU-28. The current status of the solid biofuels market is not well documented, and its development has been quite disorganized; for example, quality assurance and certification schemes are still in their very early stages of development. The purpose of the present paper is to assess the market status of biomass streams produced from the agro-industrial sector, with emphasis on those generated from the olive oil and nut processing sectors, since both can produce solid biofuels (olive stones and nut shells respectively) which are within the scope of the BIOmasud® quality label scheme. Several data sources, including national, European and international statistics, and interviews with several market actors (e.g. fuel producers) are used to provide updates and insights regarding the potential quantities and prices of these fuels. A sampling campaign and subsequent fuel analysis of the aforementioned solid biofuels also provides some first insights regarding the possibilities of applying the BIOmasud® quality label for these agro-industrial residues in Greece.
- Published
- 2018
- Full Text
- View/download PDF
8. Report on comparison among current industrial scale lignite drying technologies
- Author
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Nikolopoulos, N., Violidakis, I., Karampinis, E., Agraniotis, M., Bergins, C., and Panagiotis, G.
- Subjects
TA - Abstract
Lignite constitutes a major energy source and has long been used for energy production despite its contribution in greenhouse gas (GHG) emissions, as a fossil fuel. For example, 27.4% of Germany’s electricity originates from lignite power plants, while in Greece more than 55% of its electric energy consumption is provided by lignite. 45% of the total global coal reserves consist of low-rank coals (LRCs) such as lignite. With this background, the utilization of lignite for energy production is expected to remain a common practice in the decades to come since the availability of lignite is considerable in many countries of Europe and the world (e.g. Germany, Poland, Greece, USA, and Australia). Therefore, problems regarding the combustion and use of lignite should be addressed in a more efficient and environmentally friendly way. One of the main existing problems is the high moisture contained in raw lignite as received from the mine. The high moisture content results in higher CO2 emissions per unit of energy produced and is responsible for high capital and transport costs as well as other technical problems such as reduction in coal friability and difficulties in its blending and pneumatic transportation. Therefore, processing of lignite through drying is considered of great interest in the implementation of energy production in lignite power plants. Taking into account the significance of the subject and the usefulness of such an attempt, an overview of the currently existing drying technologies, including both evaporative and non-evaporative drying methods is reported in the present paper.
- Published
- 2015
9. Impact of Fuel Quality and Operating Phase on Emissions of a Log Wood Boiler
- Author
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Karampinis, E., Grammelis, P., Pallis, P., and Vourliotis, P.
- Subjects
Biomass - Abstract
Recent statistical surveys (2012) indicate that firewood corresponded to 23.8% of the total thermal energy consumption of households in Greece. This high percentage is a fairly recent development due to the increased taxation of heating oil and the lifting of a long-standing ban on biomass combustion in the urban centers. Good environmental performance of biomass heating systems require the use of a suitable fuel supply, however lack of experience means that customers are often unaware of the impact of fuel quality on the performance of their heating system.The purpose of this paper is to present efficiency and emission results of a 17 kW log wood boiler operated with three different varieties of wood coming from beech, olive and oak trees. The three fuel batches differ significantly in terms of main characteristics: beech: 9.5% / 0.7 %, olive tree: 13.9% / 0.6%, oak: 18.0% / 3.6% weight percentage for the as received moisture and ash on a dry basis respectively. The boiler is installed in a laboratory test stand and subjected to a common test procedure including the initial heating up phase, constant load operation and cool down phase. Emissions are continuously monitored and results indicate that during constant load operation CO, OGC, NOx and dust are generally at levels that respect the emission limits of EN 303-5 / Class 3 for all tested fuels, while NOx emissions are closely related to the fuel-N content. High CO emissions are observed for all tested fuels during the start-up phase and cool down phase, while high dust emissions during the heat-up phase are common. Overall results indicate that beech and olive tree yield quite similar environmental performance results, while oak has the higher unburnt emissions taking into account both the constant load operation and the calculated annual emissions., Proceedings of the 23rd European Biomass Conference and Exhibition, 1-4 June 2015, Vienna, Austria, pp. 712-715
- Published
- 2015
- Full Text
- View/download PDF
10. Olive Kernel and RDF Co-firing with Greek Lignite in Drop Tube Pulverized Fuel Furnace
- Author
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Karampinis, E., Vounatsos, P., Agraniotis, M., Grammelis, P., Kakaras, E., Fuller, A., Maier, J., Pagano, M., and Scheffknecht, G.
- Subjects
Biomass - Abstract
The purpose of the current work is to present the experimental results from co-firing tests performed at a 20 kWth drop tube pulverized fuel furnace installed at the Institute of Combustion and Power plant Technology (IFK), University of Stuttgart. High ash and moisture low rank lignite utilized in the Megalopolis power plant in Greece was used as the main fuel. Olive kernel produced from a olive mill and drying plant, in the vicinity of the Megalopolis plant, and Refused Derived Fuel (RDF) produced in the Athens Mechanical and Biological Treatment Plant, were chosen as potential substitution fuels, due to their local availability and low cost. Each alternative fuel was tested at thermal shares of 15 and 30%; the experimental campaign included monitoring of gaseous emissions and sampling and analysis of unburnt particles, deposits and fly ash particles from the fabric filter. A comparison of results with the reference case of 100% lignite combustion indicates that co-firing lignite with the investigated fuels has the potential for decreasing some emission types and of improving combustion conditions in the furnace; in addition, despite the higher alkali and chlorine content of the fuels, the deposits formed during co-firing appear to be more easily removed via conventional boiler cleaning equipment, as they are less molten than the lignite deposits. Overall, co-firing with olive kernel or RDF appears to be an interesting candidate for implementation at the lignitefired power plant using the investigated lignite type., Proceedings of the 21st European Biomass Conference and Exhibition, 3-7 June 2013, Copenhagen, Denmark, pp. 1180-1185
- Published
- 2013
- Full Text
- View/download PDF
11. Fouling tendency and ash deposition evaluation in large-scale pulverised fuel power plants
- Author
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Carbo, M.C., Kalivodova, J., Fuller, A.D., Maier, J., Miller, E., Karampinis, E., Lattanzi, S., Savat, P., and Energieonderzoek Centrum Nederland
- Published
- 2013
12. Study on Technical and Financial Feasibility of Biomass Co-Firing in a Greek Lignite Power Plant
- Author
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Violidakis, I., Karampinis, E., Nikolopoulos, N., Agraniotis, M., Grammelis, P., and Papapavlou, Ch.
- Subjects
Biomass - Abstract
The object of this work is a study on the application of biomass co-firing in an existing Greek lignite power plant. The Meliti - Florina Power Plant in Western Macedonia has been used as a reference station for all the case study investigations. After a brief reference to the biomass potential of Western Macedonia, an analysis of the proposed technical solutions of biomass transportation and storage system and a technical solution for the actual scenario of co-firing biomass in the concerned station is given. For the different scenarios of feeding and combustion examined, computer simulations using computational fluid dynamics code have been performed The presentation of those technical solutions is followed by the techno-economic analysis and evaluation of the extension of the power station through implementing the biomass feeding and co-firing system. Thus, despite the difficulties encountered, mainly relating to a lack of necessary quantities of biomass and the need for greater organization in the field of biomass production, the prospect of implementing co-firing biomass in existing lignite-fired power stations is presented as a realistic and feasible scenario from a technical and economic point of view., Proceedings of the 20th European Biomass Conference and Exhibition, 18-22 June 2012, Milan, Italy, pp. 1877-1890
- Published
- 2012
- Full Text
- View/download PDF
13. Investigation of Wheat Straw Supply Chains for Co-Firing Power Plants in Northern Greece
- Author
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Karampinis, E., Sissot, F., Grammelis, P., Rossi, F., and Kakaras, E.
- Subjects
Biomass - Abstract
Lignite-fired power plants in Northern Greece produce about 50% of the electricity and account for nearly 60% of the allocated CO2 emissions. The implementation of biomass co-firing is considered a cost effective and efficient method for minimizing GHG emissions. However, despite a favorable legislative framework, co-firing in Greece has not progressed since low lignite costs and distance of power plants from harbor facilities limit access to internationally traded solid biomass. The improvement and optimization of local biomass supply chains is thus a strategic priority in the national context. The purpose of the present work is to present preliminary investigations of a wheat straw supply chain for a Greek lignite-fired power plant to be converted into biomass co-firing operation. On¬field demonstration data are analyzed in order to estimate costs for supply chains involving either pelletized straw or straw bales. Information of energy consumption is also presented for different cases and GHG emissions calculated according to the methodology of (COM 2010)11. Results indicate that the cost of straw delivered at the power plant varies depending on whether pelletization is included as a supply chain step. Overall, over short distances, transfer of baled biomass is more economic and results in lower GHG emissions, however the increase in the cost of the supply chain suggest that a pelletization step should be considered for longer distances. The transport cost of the supply chain also depends on whether the vehicles are assumed to return empty at their starting point or loaded. Also, compared to imported or domestic wood pellets, straw pellets have lower prices and could be more attractive to plant operators. Long-term fuel contracts are essential in order to ensure the financial viability of co-firing, especially if a reduction in the feed-in tariff is expected., Proceedings of the 20th European Biomass Conference and Exhibition, 18-22 June 2012, Milan, Italy, pp. 136-142
- Published
- 2012
- Full Text
- View/download PDF
14. BISYPLAN: The Bioenergy System Planners Handbook
- Author
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Karampinis, E., Grammelis, P., Zethraeus, B., Andrijevskaja, J., Kask, Ü., Kask, L., Hoyne, S., Phelan, P., Casini, L., Picchi, G., Sandak, A., and Sandak, J.
- Subjects
Biomass - Abstract
The BISYPLAN project aims to produce a handbook which can be used as a reference and resource by those seeking to develop bioenergy projects in their regions. The handbook aims to provide guidance for anyone who need not understand all the fundamental aspects of biomass¬ based energy systems but who needs a conceptual and overall understanding. Target groups are those who are involved in planning, who take strategic decisions and who are involved in the procurement process, but who feels inferior to the consultants and suppliers during the process. The handbook aims to explain the underlying logics and properties that make biomass ¬based energy systems different from fossil¬ fuel based energy systems. The handbook aims to remove some of the most common misunderstandings still prevalent among many people who have no extensive experience of biomass¬ for¬ energy and hence to promote the installation of new biomass ¬based energy installations worldwide. The purpose of this presentation is to present the contents of the handbook and disseminate its existence. The handbook, which is available in four languages (English, Italian, Estonian and Greek) is based on a tabular structure, with facilitate its reading along horizontal sections divided by biomass type (lingo¬cellulosic, herbaceous, putrescible, other) and vertical sections dealing with fundamental aspects of bioenergy systems (resources, logistics, conversion, economics). The BISYPLAN handbook is available on¬line for free and is expected to increase the number of bioenergy projects that produce truly positive and sustainable results for local communities., Proceedings of the 20th European Biomass Conference and Exhibition, 18-22 June 2012, Milan, Italy, pp. 2462-2464
- Published
- 2012
- Full Text
- View/download PDF
15. Current Status and Future of Co-firing in Five EU Countries: Effect of Support Schemes, Sustainability Criteria and Biomass Markets
- Author
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Karampinis, E., Grammelis, P., and Kakaras, E.
- Subjects
Biomass - Abstract
Co-firing biomass with coal is widely considered as one of the most cost-effective and efficient methods of minimizing the GHG emissions of the electricity sector. Up to now, co-firing has been demonstrated at a number of power plants in Europe and abroad and significant operational experience and technical expertise has been accumulated. However, apart from technical issues, the adoption of co-firing for an existing power plant is a decision that relies heavily on the legislative and financial market framework. The purpose of the present work is to compare the status of co-firing activities in five European countries (Belgium, Greece, Hungary, Italy, Poland) in terms of the national support scheme for bioenergy, the presence of sustainability criteria for biomass and the structure of biomass markets. The differences in legislation and the overall market conditions produce large variations in each country, ranging from the trend to convert power plants to 100% biomass firing in Belgium, to the quick adoption of co-firing by older power stations in Hungary and Poland and to emerging initiatives, with various degrees of difficulties, in Greece and Italy. Based on these evaluations, the future perspectives of co-firing and the evolution of the respective biomass markets in each country, as well as wider EU trends, are assessed., Proceedings of the 19th European Biomass Conference and Exhibition, 6-10 June 2011, Berlin, Germany, pp. 2517-2522
- Published
- 2011
- Full Text
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16. FIUSIS, a Biomass Power Plant Fuelled Exclusively by Olive Tree Prunings. A Case Study in the AGROinLOG H2020 Project
- Author
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Pari, L., Alfano, V., Suardi, A., Palmieri, N., Karampinis, E., and Piccinni, M.
- Subjects
13. Climate action ,7. Clean energy ,agricultural residues, bioenergy, biomass, biopower plant - Abstract
In the framework of the AGROinLOG H2020 Project, the Research Centre for Engineering and Agro-Food processing of CREA was in charge of supporting the birth of a new olive tree prunings-based energy chain in the Greek Region of Fthiotida (Central Greece), with particular regard to the pruning harvesting phase. Despite the huge areas of olive grow plantations, such bioenergy chains have never taken off anywhere in the Country. On the contrary in Italy the are several practical examples of pruning utilization for energy purposes. Among these, the 1 MWe plant active in Calimera (Lecce), named Fiusis, is the first biomass power plant in the world to use exclusively olive tree prunings as a fuel source. Fiusis has been identified as a reference model to be followed in the organization of the production chain to set up in Greece. This paper reports the key elements that allowed Fiusis to achieve the success highlighting its environmental, economic and social integration with the local territory. The main technical elements of the biomass plant, the supply chain management and the operational parameters of the harvesting machineries are described. Moreover, the first achievements obtained in Greece in transferring the ���Fiusis model��� are reported.
17. From agroindustries to integrated biomass logistics centres. Agroinlog project: Summary of final results
- Author
-
Gómez, M., Zapata, S., Izquierdo, M., Jarauta-Córdoba, C., Annevelink, E., Snels, J., Urciuoli, L., Kougioumtzis, M. A., Karampinis, E., Panagiotis Grammelis, Gunnarsson, C., Lund, J., Pari, L., Suardi, A., Serrat, C., Boukis, I., Karlsson Boll, D., Gustafsson, T., Fernández, P., Rivera, S., Stavropoulou, C., Sanchez Falcon, B., Kravchenko, A., Stojiljkovic, D., and Bartolomé, C.
- Subjects
agroindustry ,biomass ,Circular economy ,Supply Chain & Information Management ,circular economy ,biobased economy ,BBP Biorefinery & Sustainable Value Chains ,Biomass ,Agroindustry ,Biobased economy - Abstract
AGROinLOG project has tested the integrated biomass logistics centres (IBLC) concept in three real agro-industries in Europe. The relevance of the IBLC strategy relies on the fact that it allows agro-industries to create a new activity with lower investment, increasing incomes, stabilizing their annual activity (avoiding idle periods) and maintaining or creating new jobs. The demos’ studies were performed in Spain at a fodder industry, in Greece at an olive oil industry, and in Sweden inside a cereal processing industry. AGROinLOG validated these demos´ business models from a holistic perspective, also studying the replicability of the IBLC business model in other agro-industries from different sectors (vegetable oil extraction, olive oil chain, feed & fodder, wine, grain chain and sugar industry). Sectorial analysis was carried out as well, allowing the identification of opportunities among the targeted sector to replicate the IBLC concept, drawing barriers to overcome in each case. Thus, technical, economic and environmental feasibility of integrated biomass logistics centers (IBLCs) for food and non-food products have been assessed in detail.
18. Quality assessment of mediterranean biofuels
- Author
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Fernández, M., Barro, R., Cortés, R., Bados, R., Brunner, T., Kanzian, W., Hajos, N., Obernberger, I., Karampinis, E., Panagiotis Grammelis, Nikolopoulos, N., Almeida, T., Mendes, C., Cancela, E., Alves, N., and Carrasco, J.
- Subjects
Biomass - Abstract
The objective of this work is to make a quality assessment of important Mediterranean biofuels as pre-normative research with the aim of revising and, eventually, adapting the currently applicable standards and/or developing new ones. For this purpose, an extensive analytical work over a total of 347 samples of biofuels and biomasses previously identified as of high potential to be widely used as fuels for heating purposes (olive tree and vineyard prunings, olives stones and different types of fruit shells) collected across 7 Mediterranean countries has been performed. The integrated statistical treatment and analysis of the results have allowed to determine relevant characteristic values of each biofuel and to compare them by country and with the quality limits in the existing related quality standards ISO 17225-2:2014 and ISO 17225-4:2014, developed to grade wood pellets and wood chips, respectively, and the Spanish standards UNE 16003:2014 and UNE 16004:2014 developed to grade olive stones and fruit shells for residential use, respectively. It can be concluded that olive tree and vineyard prunings are not generally expected to meet the quality requirements concerning ash and copper contents that are currently in place in the cited ISO standards. The UNE standards for olive stones and fruit shells could be applicable in at least all European Mediterranean countries considered in this study. The work performed may significantly contribute to the sustainable market development of the studied biofuels., Proceedings of the 26th European Biomass Conference and Exhibition, 14-17 May 2018, Copenhagen, Denmark, pp. 900-905
19. Monitoring Feedstock Losses Over 6 Months Storage of Olive Tree Prunings Hog Fuel in Piles. Comparison of Piles with or without Coverage
- Author
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Kougioumtzis, M.A., Kanaveli, I.-P., Karampinis, E., Grammelis, P., and Kakaras, E.
- Subjects
Biomass ,7. Clean energy - Abstract
Aim of the current paper is the monitoring of feedstock losses during the six months storage of harvested olive tree prunings (OTP), by comparing two storage solutions: i) uncovered, open-air storage and ii) covered storage. For this task, two identical conical piles of harvested prunings were built and monitored for calculating the changes in dry matter and energy content of the stored material over time. One pile was built as-is and the other was covered with a fleece. For each pile, sample bags were used in order to monitor the alterations in dry matter and energy content of the stored OTP. In overall, the covered pile showed greater storage performance than the uncovered pile, where the latter depended mostly on weather conditions. The covered pile presented lower dry matter losses after 6 months of storage (average value of 1.1 % compared to 4.6 % of the uncovered pile), stable moisture content throughout the storage period (around 10 % compared to fluctuating moisture content of uncovered pile from 11 % to 21 %), that also resulted in energy content gain (average pile value of energy content gain of 12.1 % compared to energy content loss of 5.1 % of the uncovered pile)., Proceedings of the 28th European Biomass Conference and Exhibition, 6-9 July 2020, Virtual, pp. 137-143
20. FIUSIS, a Biomass Power Plant Fuelled Exclusively by Olive Tree Prunings. A Case Study in the AGROinLOG H2020 Project
- Author
-
Pari, L., Alfano, V., Suardi, A., Palmieri, N., Karampinis, E., and Piccinni, M.
- Subjects
7. Clean energy ,agricultural residues, bioenergy, biomass, biopower plant - Abstract
In the framework of the AGROinLOG H2020 Project, the Research Centre for Engineering and Agro-Food processing of CREA was in charge of supporting the birth of a new olive tree prunings-based energy chain in the Greek Region of Fthiotida (Central Greece), with particular regard to the pruning harvesting phase. Despite the huge areas of olive grow plantations, such bioenergy chains have never taken off anywhere in the Country. On the contrary in Italy the are several practical examples of pruning utilization for energy purposes. Among these, the 1 MWe plant active in Calimera (Lecce), named Fiusis, is the first biomass power plant in the world to use exclusively olive tree prunings as a fuel source. Fiusis has been identified as a reference model to be followed in the organization of the production chain to set up in Greece. This paper reports the key elements that allowed Fiusis to achieve the success highlighting its environmental, economic and social integration with the local territory. The main technical elements of the biomass plant, the supply chain management and the operational parameters of the harvesting machineries are described. Moreover, the first achievements obtained in Greece in transferring the “Fiusis model” are reported.
21. FIUSIS, a Biomass Power Plant Fuelled Exclusively by Olive Tree Prunings. A Case Study in the AGROinLOG H2020 Project
- Author
-
Pari, L., Alfano, V., Suardi, A., Palmieri, N., Karampinis, E., and Piccinni, M.
- Subjects
Biomass ,7. Clean energy - Abstract
In the framework of the AGROinLOG H2020 Project, the Research Centre for Engineering and Agro-Food processing of CREA was in charge of supporting the birth of a new olive tree prunings-based energy chain in the Greek Region of Fthiotida (Central Greece), with particular regard to the pruning harvesting phase. Despite the huge areas of olive grow plantations, such bioenergy chains have never taken off anywhere in the Country. On the contrary in Italy the are several practical examples of pruning utilization for energy purposes. Among these, the 1 MWe plant active in Calimera (Lecce), named Fiusis, is the first biomass power plant in the world to use exclusively olive tree prunings as a fuel source. Fiusis has been identified as a reference model to be followed in the organization of the production chain to set up in Greece. This paper reports the key elements that allowed Fiusis to achieve the success highlighting its environmental, economic and social integration with the local territory. The main technical elements of the biomass plant, the supply chain management and the operational parameters of the harvesting machineries are described. Moreover, the first achievements obtained in Greece in transferring the “Fiusis model” are reported., Proceedings of the 28th European Biomass Conference and Exhibition, 6-9 July 2020, Virtual, pp. 977-981
22. Assessment of Biomass Resources for an Integrated Biomass Logistics Center (IBLC) Operating in the Olive Oil Sector
- Author
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Kougioumtzis, M-A., Karampinis, E., Grammelis, P., and Kakaras, E.
- Subjects
020209 energy ,020208 electrical & electronic engineering ,0202 electrical engineering, electronic engineering, information engineering ,02 engineering and technology ,Biomass - Abstract
An IBLC (Integrated Biomass Logistic Centre) is defined as a business strategy for agro-industries to take advantage of unexploited synergies in terms of facilities, equipment and staff capacities, to diversify regular activity both on the input (biomass feedstock) and output side (biocommodities & intermediate biobased feedstocks) thereby enhancing the strength of agro-industries and increasing the added value delivered by those companies. For the olive oil sector, pomace mills are the main agro-industries that can be targeted for the implementation of an IBLC concept, since they are of sufficient large size and sophistication, they have equipment (e.g. dryers) capable of handling biomass streams, they have large idle time of inactivity and, finally, they are located in areas with large untapped biomass potential from the agricultural sector, e.g. olive tree prunings. The aim of the present paper is to assess the biomass resources that can be mobilized by an IBLC operating in the olive oil sector in Central Greece. Two main input streams are considered: wet olive pomace, which is the standard incoming stream in a pomace mill, and olive tree prunings, which are the untapped local biomass potential. The outcome of the present paper is an increased understanding of the biomass resources that an olive oil sector IBLC can mobilize. This knowledge can be used to produce updated mass balances of an operating IBLC and to estimate the new revenue streams and economic opportunities that can be emerged by an olive oil IBLC. Moreover, the methodology developed in the paper to assess the biomass resources can be employed by other agro-industries, operating in the olive oil sector, in order to assess their possibilities for implementing the IBLC strategy., Proceedings of the 26th European Biomass Conference and Exhibition, 14-17 May 2018, Copenhagen, Denmark, pp. 309-313
23. Combustion of olive tree pruning pellets versus exhausted olive cake at industrial boiler. Monitoring of emissions and combustion efficiency
- Author
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Kougioumtzis, M. -A, Kanaveli, I. -P, Karampinis, E., Panagiotis Grammelis, and Kakaras, E.
- Subjects
agropellet ,biomass ,agricultural residues ,emissions ,olive tree - Abstract
The aim of the present paper is to compare the combustion behaviour of solid biofuels suitable for industrial applications: olive tree pruning (OTP) pellets and exhausted olive cake. The combustion is performed in operating conditions at one industrial fixed bed biomass boiler (0.5 MWth capacity) used to cover the heating demands of an olive mill. Combustion tests are performed at the industrial boiler for three consecutive days. During the first day the reference fuel (exhausted olive cake), that is normally used in the olive mill, is monitored whereas in the second and third day, the OTP pellets and a mixture of pellets and pulverized OTP respectively are combusted and monitored for emissions. Monitoring of emissions in terms of dust, CO, CO2, NOx, SO2, HCl and OGC emissions was performed and compared for each different fuel used. Furthermore, the boiler efficiency for each biofuel was calculated for evaluating the combustion performance of them. The combustion of the OTP fuels led to lower HCl emissions but increased CO and OGC emissions, while the ash formation exhibited signs of reduced slagging. For all fuels the high dust emissions highlighted the need for particle emission abatement equipment installation, while the behaviour of the boiler efficiency was directly linked to the air excess ratio, indicating that improved automated boiler controls are needed.
24. Bringing agro-biomass to reality: Keys for new sustainable value chains based on agricultural pruning and plantation removal biomass
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García-Galindo, D., Adeline Rezeau, Karampinis, E., and Kougioumtzis, M. -A
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11. Sustainability ,Biomass ,15. Life on land ,12. Responsible consumption - Abstract
The utilization of agro-residues as a source of biomass is an opportunity for supporting the expansion of the bioeconomy in Europe. Among the multiple agro-residues, those produced from vineyards, olive groves and fruit plantation represent a relevant potential for many EU countries. Specifically, the woody biomass residues from Agricultural Pruning and Plantation Removal (APPR in short) is a paradigm of agro-residues being produced year after year, and in most of the cases, not utilized as a resource for added value activities like the production of energy, biochemical or other biocommodities. In this paper, the uP_running project provides a vision to understand the current status of APPR biomass utilization in Europe and gives some recommendations for establishing new value chains based on this fuel. In addition, the document describes how to make the APPR biomass value chains a reality: how the different stages of the value chain and logistics can be carried out, which are the main keys to make the value chain operative, how to ensure that the final user finds an added value in the APPR biomass they receive, and how to preserve the quality and market value., Proceedings of the 26th European Biomass Conference and Exhibition, 14-17 May 2018, Copenhagen, Denmark, pp. 1569-1582
25. Greek lignite/cardoon co-firing: From cultivation to combustion trials
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Karampinis, E., Aaron Fuller, Sissot, F., Grammelis, P., Maier, J., Rossi, F., Scheffknecht, G., Krautz, M., and Kakaras, E.
26. Combustion of Olive Tree Pruning Pellets versus Exhausted Olive Cake at Industrial Boiler. Monitoring of Emissions and Combustion Efficiency
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Kougioumtzis, M.A., Kanaveli, I.-P., Karampinis, E., Grammelis, P., and Kakaras, E.
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13. Climate action ,Biomass ,7. Clean energy - Abstract
The aim of the present paper is to compare the combustion behaviour of solid biofuels suitable for industrial applications: olive tree pruning (OTP) pellets and exhausted olive cake. The combustion is performed in operating conditions at one industrial fixed bed biomass boiler (0.5 MWth capacity) used to cover the heating demands of an olive mill. Combustion tests are performed at the industrial boiler for three consecutive days. During the first day the reference fuel (exhausted olive cake), that is normally used in the olive mill, is monitored whereas in the second and third day, the OTP pellets and a mixture of pellets and pulverized OTP respectively are combusted and monitored for emissions. Monitoring of emissions in terms of dust, CO, CO2, NOx, SO2, HCl and OGC emissions was performed and compared for each different fuel used. Furthermore, the boiler efficiency for each biofuel was calculated for evaluating the combustion performance of them. The combustion of the OTP fuels led to lower HCl emissions but increased CO and OGC emissions, while the ash formation exhibited signs of reduced slagging. For all fuels the high dust emissions highlighted the need for particle emission abatement equipment installation, while the behaviour of the boiler efficiency was directly linked to the air excess ratio, indicating that improved automated boiler controls are needed., Proceedings of the 28th European Biomass Conference and Exhibition, 6-9 July 2020, Virtual, pp. 275-279
27. AgroBioHeat: Promoting Modern Agrobiomass Heating Solutions in Rural Europe
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Karampinis, E., Kanaveli, I.P., and Grammelis, P.
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13. Climate action ,11. Sustainability ,Biomass ,7. Clean energy ,12. Responsible consumption - Abstract
Different types of agrobiomass (agricultural residues, agroindustrial byproducts, fast growing energy crops and short rotation coppice) is an abundant, indigenous energy resource that can be effectively used for meeting the European decarbonisation targets. There are many potential models and technical pathways for utilizing agrobiomass in this sense; one of the most promising is its use as a heating fuel in European rural areas and in applications such as households and farms, municipal and commercial buildings, and agro-industries and greenhouses. Despite the existence of some agrobiomass heating markets in Europe, mostly based on agroindustrial biomass byproducts or straw, the full market potential of agrobiomass heating is not realized due several limiting factors. The present paper introduces AgroBioHeat (www.agrobioheat.eu), a project funded by the European Union’s Horizon 2020 research and innovation programme, that aims to develop into a comprehensive platform for the market uptake of agrobiomass heating solutions through the implementation of a variety of activities design to develop trust in the capacity of this technology to decarbonize the rural heating market, develop vision for its deployment and provide support to a number of initiatives that will be implemented by the project. The paper serves as an introduction to the current framework conditions for agrobiomass heating and to the overall strategy and approach followed by the AgroBioHeat project., Proceedings of the 27th European Biomass Conference and Exhibition, 27-30 May 2019, Lisbon, Portugal, pp. 1873-1877
28. 'Mediterranean' Solid Biofuels from Agro-Industrial Residues in Greece: Market Status and Prospectives for the Domestic Heating Sector
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Karampinis, E., Kougioumtzis, M-A., Grammelis, P., and Kakaras, E.
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13. Climate action ,11. Sustainability ,Biomass ,7. Clean energy ,12. Responsible consumption - Abstract
The biomass use in the domestic heating sector in Greece has undergone an expansion since 2011, mostly due to two factors: the financial crisis and the increased taxation of heating oil on the one hand, and the lifting of the ban to biomass combustion in large urban areas. More than 80 % of the bioenergy consumption in Greece is coming from the residential sector and biomass is the RES with the highest contribution to the national primary energy consumption. However, the per capita consumption of solid biofuels is still one of the lowest in the EU-28. The current status of the solid biofuels market is not well documented, and its development has been quite disorganized; for example, quality assurance and certification schemes are still in their very early stages of development. The purpose of the present paper is to assess the market status of biomass streams produced from the agro-industrial sector, with emphasis on those generated from the olive oil and nut processing sectors, since both can produce solid biofuels (olive stones and nut shells respectively) which are within the scope of the BIOmasud® quality label scheme. Several data sources, including national, European and international statistics, and interviews with several market actors (e.g. fuel producers) are used to provide updates and insights regarding the potential quantities and prices of these fuels. A sampling campaign and subsequent fuel analysis of the aforementioned solid biofuels also provides some first insights regarding the possibilities of applying the BIOmasud® quality label for these agro-industrial residues in Greece., Proceedings of the 26th European Biomass Conference and Exhibition, 14-17 May 2018, Copenhagen, Denmark, pp. 1621-1627
29. Autoimmune Thyroiditis in Patients With Hidradenitis Suppurativa: A Comparative Cross-Sectional Study.
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Koumaki D, Koumaki V, Gregoriou S, Evangelou G, Rovithi E, Petrou D, Apokidou ES, Katoulis A, Ioannou P, Doxastaki A, Zografaki K, Rogdakis A, Karampinis E, and Krasagakis K
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- 2025
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30. Non-Melanoma Skin Cancer: Assessing the Systemic Burden of the Disease.
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Karampinis E, Koumaki D, Sgouros D, Nechalioti PM, Toli O, Pappa G, Papadakis M, Georgopoulou KE, Schulze-Roussaki AV, and Kouretas D
- Abstract
The emergence of systemic therapies and photoprotection against non-melanoma skin cancer (NMSC) raises questions on the broader systematic impact of the disease. Personalized medicine involves a holistic patient approach, through which the evaluation of systemic biomarkers can reveal the interconnected aspects of patient health and tailored therapies. Cumulative UV exposure disrupts redox equilibrium and triggers inflammation and cutaneous immunosuppression, processes that contribute independently or via their interplay to cutaneous carcinogenesis. This systemic impact can be further reinforced by biomolecules derived from the NMSC microenvironment, fueling a continuous cycle of oxidative stress and inflammation in the organism. Regarding investigation of the systemic burden of NMSC, we conducted a narrative review focusing on parameters related to redox status, inflammation, and immune suppression observed in the blood components (serum, plasma, and erythrocytes) of NMSC patients. Our findings revealed an association of NMSC patients with perturbations of redox homeostasis, as evidenced by the decreased antioxidant activity, lower levels of non-enzymatic antioxidants, and increased byproducts of lipid, protein, and DNA oxidative damage. Additionally, NMSC patients presented augmented levels of pro-inflammatory interleukins, reduced anti-tumor biomolecule levels, and enhanced immune response markers, as well as elevated vitamin D levels. These systemic changes may lead to the association of NMSC with a higher risk of secondary malignancies in other organs. Overall, the findings of the present study suggest that NMSC affects systemic health beyond the skin, underscoring the need for a comprehensive and individualized approach to the management and monitoring of the patient.
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- 2025
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31. Exploring Pediatric Dermatology in Skin of Color: Focus on Dermoscopy.
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Karampinis E, Toli O, Georgopoulou KE, Papadopoulou MM, Vardiampasi A, Zafiriou E, Lazaridou E, Apalla Z, Lallas A, Behera B, and Errichetti E
- Abstract
This literature review aims to comprehensively evaluate the clinical and dermoscopic presentations of common pediatric diseases among children with skin of color (SoC) while also addressing potential variations based on racial backgrounds. This review encompasses various conditions, such as nevi subtypes, viral infections, infestations, and inflammatory dermatoses, as well as hair diseases and abnormal vascular formations, occurring in pediatric populations. Overall, we identified 7 studies on nevi subtypes, 24 studies on skin infections, 6 on inflammatory dermatoses, 10 on hair diseases and disorders, and 14 on miscellaneous disorders that also satisfied our SoC- and race-specific criteria. In case of no results, we assumed that dermoscopic findings are similar between SoC adults and children, confirming the hypothesis with our cases of dark-skinned Indian child patients. Inflammatory dermatoses such as psoriasis, eczema, and cutaneous mastocytosis, as well as skin infections like cutaneous leishmaniasis, appear with brownish backgrounds or exhibit dark structures more frequently than the respective dermoscopy images of Caucasian populations. Dermoscopy traits such as erythema in tinea capitis are uncommon or even absent on a dark-colored scalp, while a dark skin tone often obscures many characteristic features, such as dark and yellow dots in alopecia areata and even parts of an intradermal parasite in the case of scabies. Race-specific traits were also observed, such as corkscrew hair in tinea capitis, primarily seen in patients of African origin. Many dermoscopic images are consistent between SoC and non-SoC in various skin lesions, including vascular anomalies, juvenile xanthogranuloma, mastocytoma, and viral skin lesions like molluscum contagiosum, as well as in various hair disorders such as trichotillomania, while tinea capitis displays the most diverse reported dermoscopic features across SoC- and race-specific studies.
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- 2024
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32. "Chasing Rainbows" Beyond Kaposi Sarcoma's Dermoscopy: A Mini-Review.
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Karampinis E, Toli O, Pappa G, Vardiampasi A, Theofili M, Zafiriou E, Bobos M, Lallas A, Lazaridou E, Behera B, and Apalla Z
- Abstract
The dermoscopic rainbow pattern (RP), also known as polychromatic pattern, is characterized by a multicolored appearance, resulting from the dispersion of polarized light as it penetrates various tissue components. Its separation into different wavelengths occurs according to the physics principles of scattering, absorption, and interference of light, creating the optical effect of RP. Even though the RP is regarded as a highly specific dermoscopic indicator of Kaposi's sarcoma, in the medical literature, it has also been documented as an atypical dermoscopic finding of other non-Kaposi skin entities. We aim to present two distinct cases-a pigmented basal cell carcinoma (pBCC) and an aneurysmatic dermatofibroma-that exhibited RP in dermoscopy and to conduct a thorough review of skin conditions that display RP, revealing any predisposing factors that could increase the likelihood of its occurrence in certain lesions. We identified 33 case reports and large-scale studies with diverse entities characterized by the presence of RP, including skin cancers (Merkel cell carcinoma, BCC, melanoma, etc.), adnexal tumors, special types of nevi (blue, deep penetrating), vascular lesions (acroangiodermatitis, strawberry angioma, angiokeratoma, aneurismatic dermatofibromas, etc.), granulation tissue, hypertrophic scars and fibrous lesions, skin infections (sporotrichosis and cutaneous leishmaniasis), and inflammatory dermatoses (lichen simplex and stasis dermatitis). According to our results, the majority of the lesions exhibiting the RP were located on the extremities. Identified precipitating factors included the nodular shape, lesion composition and vascularization, skin pigmentation, and lesions' depth and thickness. These parameters lead to increased scattering and interference of light, producing a spectrum of colors that resemble a rainbow.
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- 2024
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33. Clinical and Dermoscopic Patterns of Basal Cell Carcinoma and Its Mimickers in Skin of Color: A Practical Summary.
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Karampinis E, Georgopoulou KE, Kampra E, Zafiriou E, Lallas A, Lazaridou E, Apalla Z, Behera B, and Errichetti E
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- Humans, Diagnosis, Differential, Carcinoma, Basal Cell diagnostic imaging, Carcinoma, Basal Cell diagnosis, Dermoscopy methods, Skin Neoplasms diagnostic imaging, Skin Neoplasms diagnosis, Skin Pigmentation
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The diagnosis of basal cell carcinoma (BCC) in dark phototypes can be a challenging task due to the lack of relevant clues and its variable presentation. In this regard, there is growing evidence that dermoscopy may benefit the recognition of BCC even for skin of color (SoC). The objective of this review is to provide an up-to-date overview on clinical and dermoscopic patterns of BCC in SoC, also comparing such findings with those of the main clinical mimickers reported in the literature. A comprehensive search of the literature through the PubMed electronic database was carried out in order to identify papers describing the clinical and dermoscopic features of BCC in dark phototypes (IV-VI). By finding macroscopic clinical presentations of BCCs in SoC patients and any possible clinical mimickers considered in the retrieved papers, we built a differential diagnosis list and analyzed the dermoscopic findings of such conditions to facilitate the diagnosis of BCC. BCC in darker skin may present as pigmented nodular lesions, pigmented patches or plaques, ulcers, erythematous nodular lesions, erythematous plaques or patches, or scar-like lesions, depending on its subtype and body site. The differential diagnosis for BCC in patients with SoC includes squamous cell carcinoma, melanoma, nevi, adnexal tumors and sebaceous keratosis. Additionally, it differs from that of Caucasians, as it also includes lesions less common in fair skin, such as dermatosis papulosa nigra, melanotrichoblastoma, and pigmented dermatofibrosarcoma protuberans, and excludes conditions like actinic keratosis and keratoacanthoma, which rarely appear in darker skin. The resulting differences also include infectious diseases such as deep cutaneous mycosis and inflammatory dermatoses. The most prevalent differentiating dermoscopic feature for BCC includes blue, black and gray dots, though arborizing vessels still remain the predominant BCC feature, even in dark phototypes. Diagnostic approach to BCC in dark-skinned patients varies due to the prevalence of dermoscopy findings associated with hyperpigmented structures. Clinicians should be aware of such points of differentiation for a proper management of this tumor in SoC.
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- 2024
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34. Laser-Induced Koebner-Related Skin Reactions: A Clinical Overview.
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Karampinis E, Georgopoulou KE, Goudouras G, Lianou V, Kampra E, Roussaki Schulze AV, and Zafiriou E
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- Humans, Skin Diseases etiology, Laser Therapy methods, Laser Therapy adverse effects, Skin radiation effects, Skin injuries, Skin pathology, Female, Lasers adverse effects
- Abstract
The Koebner phenomenon (KP), also known as the isomorphic response, describes the process by which new lesions that are clinically and histologically identical to a patient's existing skin disease develop following trauma. Many skin diseases exhibit this characteristic, with variations that include possible, questionable, and pseudo-Koebner reactions, with the latter category occurring due to infectious agents seeding at a trauma site. Laser application, a type of controlled skin injury used for improving cutaneous lesions and skin rejuvenation, is also considered a form of trauma. This raises the question of whether controlled thermal injury can be regarded as a type of mechanical trauma capable of producing Koebner-related reactions. We conducted a literature review of cases or studies to identify laser-induced dermatoses that correspond to Koebner-related or pathergy reaction categories. As a whole, we identified nine case reports on true KPs, two cases on possible KPs, seventeen cases on laser-induced questionable KPs comprising cases of vasculitis, eczema or Meyerson reactions, and eruptive squamous atypia cases (ESA) as well as two pseudo-Koebner cases involving wart occurrences at laser application sites. Laser-induced Koebner reactions highlight several aspects of the KP. Firstly, the type of mechanical damage influences disease promotion, as different lasers are associated with different KPs. For example, hair removal lasers are linked with true and questionable KPs such as vasculitis while resurfacing lasers were found to be more connected with ESA occurrence. Secondly, the laser target is significant, with vascular laser application for port-wine stains tending to result in eczematous reactions, while hair follicle destruction can frequently lead to true KPs. Thirdly, the number of sessions matters; true KPs and eruptive squamous atypia questionable KPs typically appear after one to two sessions, whereas eczematous reactions require more sessions (at least four). Additionally, skin phototype is crucial, with darker phototypes showing a higher KP frequency as laser treatment for hypertrichosis relies on melanin absorption in the hair bulge or bulb for follicle destruction, as chromophore competes with the abundant melanin in the epidermis. Further research with larger-scale studies into trauma-specific Koebner reactions is vital for refining treatment protocols, minimizing post-laser adverse effects, and improving dermatological care outcomes.
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- 2024
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35. Effective Management of Life-Threatening Generalized Pustular Psoriasis Flare With Spesolimab.
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Zafiriou E, Karampinis E, Giannoulis G, Gravani A, Gampeta S, and Zachou K
- Abstract
Generalized pustular psoriasis (GPP) presents as a severe variant of psoriasis featuring painful, sterile pustules on red skin and can lead to life-threatening complications if left untreated. The disease course is typically unpredictable, with periods of improvement, followed by relapses over extended periods. Managing GPP flares is challenging due to their potential to endanger the patient's life, underscoring the need for treatments that are both fast-acting and highly effective in the case of severe and systematically ill GPP patients. We present a case of a 48-year-old man with an extensive and severe GPP flare (GPP Physician Global Assessment score = 4), experiencing an extensive pustular rash on an erythematous base, intense skin exfoliation, and inflammation as well as systemic symptoms such as fever, hypotension, and general weakness. During the disease course, he developed comorbidities such as depression occurrence and an episode of an acute pulmonary embolism. Initial treatment attempts with acitretin and anakinra were not proved successful. Due to IL-36's significant role in GPP pathophysiology, the patient received treatment involving an IL-36 receptor antagonist (two infusions of 900 mg spesolimab administered one week apart), alongside continued acitretin therapy. This approach led to swift improvement, resolving pustules and skin inflammation and resulting in the patient's gradual recovery. This case highlights spesolimab's potential as a targeted therapy for severe GPP flares resistant to conventional treatments. However, further research is needed to establish its long-term safety and efficacy in managing GPP and related IL-36-mediated diseases., Competing Interests: Human subjects: Consent was obtained or waived by all participants in this study. Conflicts of interest: In compliance with the ICMJE uniform disclosure form, all authors declare the following: Payment/services info: All authors have declared that no financial support was received from any organization for the submitted work. Financial relationships: All authors have declared that they have no financial relationships at present or within the previous three years with any organizations that might have an interest in the submitted work. Other relationships: All authors have declared that there are no other relationships or activities that could appear to have influenced the submitted work., (Copyright © 2024, Zafiriou et al.)
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- 2024
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36. Can Artificial Intelligence "Hold" a Dermoscope?-The Evaluation of an Artificial Intelligence Chatbot to Translate the Dermoscopic Language.
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Karampinis E, Toli O, Georgopoulou KE, Kampra E, Spyridonidou C, Roussaki Schulze AV, and Zafiriou E
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This survey represents the first endeavor to assess the clarity of the dermoscopic language by a chatbot, unveiling insights into the interplay between dermatologists and AI systems within the complexity of the dermoscopic language. Given the complex, descriptive, and metaphorical aspects of the dermoscopic language, subjective interpretations often emerge. The survey evaluated the completeness and diagnostic efficacy of chatbot-generated reports, focusing on their role in facilitating accurate diagnoses and educational opportunities for novice dermatologists. A total of 30 participants were presented with hypothetical dermoscopic descriptions of skin lesions, including dermoscopic descriptions of skin cancers such as BCC, SCC, and melanoma, skin cancer mimickers such as actinic and seborrheic keratosis, dermatofibroma, and atypical nevus, and inflammatory dermatosis such as psoriasis and alopecia areata. Each description was accompanied by specific clinical information, and the participants were tasked with assessing the differential diagnosis list generated by the AI chatbot in its initial response. In each scenario, the chatbot generated an extensive list of potential differential diagnoses, exhibiting lower performance in cases of SCC and inflammatory dermatoses, albeit without statistical significance, suggesting that the participants were equally satisfied with the responses provided. Scores decreased notably when practical descriptions of dermoscopic signs were provided. Answers to BCC scenario scores in the diagnosis category (2.9 ± 0.4) were higher than those with SCC (2.6 ± 0.66, p = 0.005) and inflammatory dermatoses (2.6 ± 0.67, p = 0). Similarly, in the teaching tool usefulness category, BCC-based chatbot differential diagnosis received higher scores (2.9 ± 0.4) compared to SCC (2.6 ± 0.67, p = 0.001) and inflammatory dermatoses (2.4 ± 0.81, p = 0). The abovementioned results underscore dermatologists' familiarity with BCC dermoscopic images while highlighting the challenges associated with interpreting rigorous dermoscopic images. Moreover, by incorporating patient characteristics such as age, phototype, or immune state, the differential diagnosis list in each case was customized to include lesion types appropriate for each category, illustrating the AI's flexibility in evaluating diagnoses and highlighting its value as a resource for dermatologists.
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- 2024
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37. Multiple Keratoacanthoma-like Syndromes: Case Report and Literature Review.
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Karampinis E, Kostopoulou C, Toli O, Marinos L, Papadimitriou G, Roussaki Schulze AV, and Zafiriou E
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- Humans, Female, Adult, Acitretin therapeutic use, Fluorouracil therapeutic use, Keratoacanthoma diagnosis, Keratoacanthoma drug therapy, Keratoacanthoma pathology, Skin Neoplasms diagnosis, Skin Neoplasms drug therapy, Carcinoma, Squamous Cell diagnosis
- Abstract
Keratoacanthoma (KA) is a fast-growing skin tumor subtype that can be observed as a solitary lesion or rarely as multiple lesions in the context of rare genetic syndromes. Syndromes with multiple keratoacanthoma-like lesions have been documented as multiple self-healing squamous epithelioma (Ferguson-Smith syndrome), eruptive keratoacanthoma of Grzybowski, multiple familial keratoacanthoma of Witten and Zak Muir-Torre syndrome, and incontinentia pigmenti. The treatment approach of those entities is challenging due to the numerous lesions, the lesions' undefined nature, and the co-existence of other malignant skin tumors. Herein, we report a case of a 40-year-old woman who developed multiple treatment-resistant Ferguson-Smith-like keratoacanthomas with a co-existing large and ulcerated invasive squamous cell carcinoma and microcystic adnexal carcinoma on the scalp. Multiple keratoacanthomas on her extremities were successfully treated with oral acitretin (0.5 mg/kg/day) in combination with topical Fluorouracil (5-FU) 5%, while excision and plastic surgery restoration were performed to treat the ulcerated cancer lesion on her scalp. Due to the interesting nature of this rare syndrome, we performed a literature review including case reports and case series on multiple-KA-like lesions syndromes and focusing on diagnosis and therapy approaches. We also conducted a comparison of patient reports, which included assessing the clinical appearance of the lesions and evaluating the success and progress or the failure of various treatment approaches that were implemented.
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- 2024
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38. Plaque Psoriasis Exacerbation and COVID-19 Vaccination: Assessing the Characteristics of the Flare and the Exposome Parameters.
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Karampinis E, Papadopoulou MM, Chaidaki K, Georgopoulou KE, Magaliou S, Roussaki Schulze AV, Bogdanos DP, and Zafiriou E
- Abstract
The diverse patient population and widespread vaccination in the COVD-19 era make vaccine-triggered episodes of psoriasis an ideal model of exposome research. This scenario explores the fine balance between protective and exacerbating factors, providing insights into the complex relationship between environmental exposure and psoriasis immunopathogenesis when a trigger appears, such as that of the hyperinflammatory state induced by the COVID-19 vaccine. Analyzing interactions between vaccine-induced phenomena and exposome parameters may provide clinically relevant information important for personalized medicine decision-making. We performed a literature review seeking patients with plaque psoriasis flares or new onset or change in plaque psoriasis into another psoriasis subtype, such as pustular or erythrodermic flare, focusing on the inner and external exposome traits of patients. We identified 71 patients with plaque psoriasis flares, 12 patients with new-onset psoriasis, and 17 with plaque psoriasis subtype change, and assessed the COVID-19 vaccine-induced plaque psoriasis in terms of clinical presentation, post-vaccination flare period and treatment status, as well as inner exposome parameters (genomics, oxidative stress, hormonal impact due to gender, aging, skin color) and external parameters (UV, infectomics). Novel data on psoriasis flares following COVID-19 vaccination are primarily obtained by combining exposome and vaccine-triggered episode features and characteristics and comparing them with similar psoriasis flares unrelated to COVID-19 vaccination.
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- 2024
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39. Race-Specific and Skin of Color Dermatoscopic Characteristics of Skin Cancer: A Literature Review.
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Karampinis E, Lallas A, Lazaridou E, Errichetti E, and Apalla Z
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Introduction: Individuals with melanin-rich skin account for the majority of the world's population. However, literature data regarding dermatoscopic characteristics of skin cancer in skin of color (SoC) are scarce. The dermatoscopic characteristics of cutaneous tumors might differ among skin types due to heterogeneity in composition and pigmentation., Objectives: To summarize literature data on the dermatoscopic findings of skin neoplasms, according to the skin color and race., Methods: The literature search was performed using PubMed database up to December 30, 2022 and was conducted with the use of terms referring to dermatoscopy, race (Caucasians, Hispanics, Asians, and Black/African) and skin cancer types (BCC, SCC, keratoacanthoma, Bowen's disease and melanoma)., Results: In total, 30 race-specific records were included. 9 SoC records for BCCs (2 BCC studies in Hispanics, 1 BCC study in Black individuals and 6 BCC studies in Asians ), 9 SoC records for SCCs ( 1 SCC study in Hispanics, 1 SCC study in Black individuals and 7 SCCs in Asian population) and 8 SoC records for melanoma (2 melanoma studies in Hispanics, 1 melanoma study in Blacks and 5 melanoma studies in Asians) were compared with 4 records that involved only Caucasian population, according to their participant section as well as with studies on dermatoscopy characteristics without focusing on race origins and phototype of the patient. In Hispanics and in both fair and dark-skinned Asians, BCCs were more often pigmented or at least with pigmented structures on dermoscopy. Squamous cell carcinoma (SCC) and keratoacanthoma were the least studied in SoC patients. Bowen's disease in SoC patients can be pigmented in a higher frequency compared to Caucasians, with glomerular vessels and a squamous surface being the most common dermatoscopic findings. The most frequent pattern of melanomas in SoC individuals were the parallel ridge pattern in palmoplantar region., Conclusion: Based on a review of studies including Caucasians, Hispanics, Asians and Blacks /Africans, SoC patients present with more frequent and unique dermatoscopy features of skin cancers.
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- 2023
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40. Pustular Eruption following COVID-19 Vaccination: A Narrative Case-Based Review.
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Karampinis E, Gravani A, Gidarokosta P, Bogdanos DP, Roussaki-Schulze AV, and Zafiriou E
- Abstract
From the beginning of public vaccinations until the relaxation of COVID-19 measures, many case reports, case series and case-control studies have been published indicating cutaneous side effects of COVID-19 vaccination. Post-vaccination pustular eruption was reported as well, with a challenging differential diagnosis between pustular psoriasis, AGEP (acute generalized exanthematous pustulosis) and neutrophil pustular eruptions. We report a case of 56-year-old woman presented with acute generalized pustular flare up culminated 5 days after the second dose of BNT162b2(Pfizer) vaccination. She was diagnosed with pustular psoriasis flare and due to the regulating role of IL-1 in pustular psoriasis and in the cytokine storm observed in cases of COVID-19 postvaccination inflammation; we decided to treat the patient with an IL-1 antagonist, subcutaneous anakinra (100 mg daily) along with acitretin. One week later, after anakinra withdrawal, she presented a pustular psoriasis flare and a 7-day anakinra re-administration led to a satisfactory improvement in the skin lesions. We also reviewed the medical literature and found 28 case reports with pustular eruption after the COVID-19 vaccination. We compared the patients reported, regarding sex, age, number of doses, post-vaccination period and vaccine brand, and compared those results with our patient. Finally, as indicated by our case and other cases with similarly treated pustular eruptions. targeted therapy to this cytokine imbalance such as anakinra (IL-1) antagonist can improve the clinical course of the patient.
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- 2023
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41. Serum vitamin D levels can be predictive of psoriasis flares up after COVID-19 vaccination: a retrospective case control study.
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Karampinis E, Goudouras G, Ntavari N, Bogdanos DP, Roussaki-Schulze AV, and Zafiriou E
- Abstract
Introduction: Many patients with chronic inflammatory dermatosis such as psoriasis usually ask about the safety of COVID-19 vaccination and if it would affect the course of their disease. Indeed, many case reports, case series and clinical studies, reporting psoriasis exacerbation following vaccination against COVID-19, were published during the pandemic. Also, many questions arise regarding the existence of exacerbating factors of these flare ups, including environmental triggers such as the insufficiency of vitamin D levels., Methods: This is a retrospective study that measures alterations in psoriasis activity and severity index (PASI) not exceeding 2 weeks after the first and second dose of COVID-19 vaccinations in the reported cases and assesses whether such changes have any association with patients' vitamin D levels. We retrospectively reviewed the case records of all patients with a documented flare up after COVID-19 vaccination in our department as well as those who did not, during a year., Results: Among them, we found 40 psoriasis patients that had reported vitamin D levels in the form of 25-hydroxy-vitamin D within 3 weeks after vaccination, including 23 with exacerbation and 17 without exacerbation. Performing χ
2 and t -test controls for psoriasis patients with and without flare-ups, a statistically significant dependence emerged in the seasons of summer [χ2 (1) = 5.507, p = 0.019], spring [χ2 (1) = 11.429, p = 0.001] and in the categories of vitamin D [χ2 (2) = 7.932, p = 0.019], while the mean value of vitamin D for psoriasis patients who did not have exacerbation (31.14 ± 6.67 ng/mL) is statistically higher [ t (38) = 3.655, p = 0.001] than the corresponding value of psoriasis patients who had an exacerbation (23.43 ± 6.49 ng/mL)., Discussion: This study indicates that psoriasis patients with insufficient (21-29 ng/mL) or inadequate (<20 ng/mL) levels of vitamin D are more prone to postvaccination aggravation of the disease while vaccination in summer, a period with the most extent photo-exposition, can be a protective factor., Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest., (Copyright © 2023 Karampinis, Goudouras, Ntavari, Bogdanos, Roussaki-Schulze and Zafiriou.)- Published
- 2023
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42. Non-Melanoma Skin Cancer and Vitamin D: The "Lost Sunlight" Paradox and the Oxidative Stress Explanation.
- Author
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Karampinis E, Aloizou AM, Zafiriou E, Bargiota A, Skaperda Z, Kouretas D, and Roussaki-Schulze AV
- Abstract
UV radiation (UVR) is responsible for inducing both harmful and beneficial effects on skin health. Specifically, it has been reported to disrupt oxidant and antioxidant levels, leading to oxidative stress conditions in skin tissue. This phenomenon might trigger photo-carcinogenesis, resulting in melanoma, NMSC (non-melanoma skin cancer), such as BCC (basal cell carcinoma) and SCC (squamous cell carcinoma), and actinic keratosis. On the other hand, UVR is essential for the production of adequate vitamin D levels, a hormone with important antioxidant, anticancer and immunomodulatory properties. The exact mechanisms implicated in this two-fold action are not well understood, as there still no clear relation established between skin cancer and vitamin D status. Oxidative stress seems to be a neglected aspect of this complex relation, despite its role in both skin cancer development and vitamin D deficiency. Therefore, the aim of the present study is to examine the correlation between vitamin D and oxidative stress in skin cancer patients. A total of 100 subjects (25 with SCC, 26 with BCC, 23 with actinic keratosis, and 27 controls) were assessed in terms of 25-hydroxyvitamin D (25(OH) D) and redox markers such as thiobarbituric acid reactive substances (TBARS), protein carbonyls, total antioxidant capacity (TAC) in plasma, glutathione (GSH) levels and catalase activity in erythrocytes. The majority of our patients revealed low vitamin D levels; 37% of the subjects showed deficiency (<20 ng/mL) and 35% insufficiency (21-29 ng/mL). The mean 25(OH) D level of the NMSC patients (20.87 ng/mL) was also found to be significantly lower ( p = 0.004) than that of the non-cancer patients (28.14 ng/mL). Furthermore, higher vitamin D levels were also correlated with lower oxidative stress (positive correlation with GSH, catalase activity TAC index and negative correlation with TBARS and CARBS indices). NMSC patients diagnosed with SCC showed lower catalase activity values compared to non-cancer patients ( p < 0.001), with the lowest values occurring in patients with a chronic cancer diagnosis ( p < 0.001) and vitamin D deficiency ( p < 0.001). Higher GSH levels ( p = 0.001) and lower TBARS levels ( p = 0.016) were found in the control group compared to the NMSC group, and to patients with actinic keratosis. Higher levels of CARBS were observed in patients with SCC ( p < 0.001). Non-cancer patients with vitamin D sufficiency showed higher TAC values compared to non-cancer patients with vitamin D deficiency ( p = 0.023) and to NMSC patients ( p = 0.036). The above-mentioned results indicate that NMSC patients reveal increased levels of oxidative damage markers compared to control levels, while vitamin D status plays a critical role in the determination of individuals' oxidative status.
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- 2023
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43. CYP1A2 rs762551 polymorphism and risk for amyotrophic lateral sclerosis.
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Siokas V, Karampinis E, Aloizou AM, Mentis AA, Liakos P, Papadimitriou D, Liampas I, Nasios G, Bogdanos DP, Hadjigeorgiou GM, and Dardiotis E
- Subjects
- Genetic Predisposition to Disease, Genotype, Humans, Polymorphism, Single Nucleotide genetics, Amyotrophic Lateral Sclerosis genetics, Cytochrome P-450 CYP1A2 genetics
- Abstract
Background: Genetic variability is considered to confer susceptibility to amyotrophic lateral sclerosis (ALS). Oxidative stress is a significant contributor to ALS-related neurodegeneration, and it is regulated by cytochromes P450 (CYPs), such as CYP1A2; these are responsible for the oxidative metabolism of both exogenous and endogenous substrates in the brain, subsequently impacting ALS. The function of CYP1A2 is largely affected by genetic variability; however, the impact of CYP1A2 polymorphisms in ALS remains underinvestigated., Objective: This study aims to examine the possible association of ALS with the CYP1A2 rs762551 polymorphism, which codes for the high inducibility form of the enzyme., Methods: One hundred and fifty-five patients with sporadic ALS and 155 healthy controls were genotyped for the CYP1A2 rs762551. Statistical testing for the association of CYP1A2 rs762551 with risk for ALS was performed using SNPstats., Results: The CYP1A2 rs762551 C allele was associated with a decreased risk of ALS development. In the subgroup analysis according to the ALS site of onset, an association between CYP1A2 rs762551 and limb and bulbar onset of ALS was shown. Cox proportional-hazard regression analyses revealed a significant effect of the CYP1A2 rs762551 on the age of onset of ALS., Conclusions: Based on our results, a primarily potential link between the CYP1A2 rs762551 polymorphism and ALS risk could exist.
- Published
- 2021
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44. Does SCFD1 rs10139154 Polymorphism Decrease Alzheimer's Disease Risk?
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Stamati P, Siokas V, Aloizou AM, Karampinis E, Arseniou S, Rakitskii VN, Tsatsakis A, Spandidos DA, Gozes I, Mitsias PD, Bogdanos DP, Hadjigeorgiou GM, and Dardiotis E
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- Aged, Aged, 80 and over, Female, Humans, Male, Adaptor Proteins, Vesicular Transport genetics, Alzheimer Disease genetics, Polymorphism, Single Nucleotide
- Abstract
Α number of genetic variants have been associated with Alzheimer's disease (AD) susceptibility. Sec1 family domain-containing protein 1 (SCFD1) gene polymorphism rs10139154 has recently been implicated in the risk of developing amyotrophic lateral sclerosis (ALS). Similarities in the pathogenetic cascade of both diseases have also been described. The present study was designed to evaluate the possible contribution of SCFD1 rs10139154 to AD. A total of 327 patients with AD and an equal number of healthy controls were included in the study and genotyped for rs10139154. With logistic regression analyses, rs10139154 was examined for the association with the risk of developing AD. In the recessive mode, SCFD1 rs10139154 was associated with a decreased risk of developing AD (odds ratio (OR) (95% confidence interval (CI)) = 0.63 (0.40-0.97), p = 0.036). The current study provides preliminary evidence of the involvement of SCFD1 rs10139154 in the risk of developing AD.
- Published
- 2019
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45. ERCC6L2 rs591486 polymorphism and risk for amyotrophic lateral sclerosis in Greek population.
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Dardiotis E, Karampinis E, Siokas V, Aloizou AM, Rikos D, Ralli S, Papadimitriou D, Bogdanos DP, and Hadjigeorgiou GM
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- Aged, Female, Genetic Association Studies, Genotype, Greece, Humans, Male, Middle Aged, Polymorphism, Single Nucleotide, White People genetics, Amyotrophic Lateral Sclerosis genetics, DNA Helicases genetics, Genetic Predisposition to Disease
- Abstract
Background: Α number of genetic variants have been associated with amyotrophic lateral sclerosis (ALS). A recent study supports that rs591486 across the ERCC6L2 gene and exposure to pesticides seem to have a joint effect on the development of Parkinson's disease, a disease which shares a few common characteristics with ALS., Objective: To detect a possible contribution of rs591486 ERCC6L2 to ALS., Methods: A total of 155 patients with ALS and 155 healthy controls were included in the study and genotyped for rs591486. Using logistic regression analyses (crude and adjusted for age and sex), rs591486 was tested for association with ALS risk. Subgroup analysis based on ALS site of onset was also performed. Cox regression analysis was applied in order for the effect of ERCC6L2 rs591486 on ALS age of onset to be tested., Results: Adjusted analysis showed that ERCC6L2 rs591486 was associated with an increased risk of ALS development, in dominant [odds ratio, OR (95% confidence interval, CI) 2.15 (1.04-4.46), p = 0.037] and over-dominant [OR (95%CI) = 1.91 (1.01-3.60), p = 0.043], modes. Subgroup analysis based on ALS site of onset revealed an association between ERCC6L2 rs591486 and ALS with limb onset. Results for Cox regression analysis indicated that G/A carriers had a lower age of ALS limb onset when compared to G/G carriers., Conclusions: The current study provides preliminary indication for an implication of ERCC6L2 rs591486 in ALS development, as a possible genetic risk factor. These results possibly suggest that oxidative stress may be the main contributor in the pathophysiology of ALS.
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- 2019
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46. Effect of integrin AV and B8 gene polymorphisms in patients with traumatic brain injury.
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Dardiotis E, Siokas V, Aloizou AM, Karampinis E, Brotis AG, Grigoriadis S, Paterakis K, Dardioti M, Komnos A, Kapsalaki E, Fountas K, and Hadjigeorgiou GM
- Subjects
- Adolescent, Adult, Aged, Aged, 80 and over, Brain Injuries, Traumatic complications, Cerebral Hemorrhage etiology, Female, Humans, Male, Middle Aged, Young Adult, Brain Injuries, Traumatic genetics, Cerebral Hemorrhage genetics, Genotype, Integrin alphaV genetics, Integrin beta Chains genetics, Polymorphism, Single Nucleotide
- Abstract
Background: Α few genetic variants are associated with the outcome after traumatic brain injury (TBI). Integrins are glycoprotein receptors that play an important role in the integrity of microvasculature of the brain. Objective: To examine the role of integrin-AV ( ITGAV ) and integrin-B8 ( ITGB8 ) tag single nucleotide polymorphisms (SNPs) on the outcome of patients with TBI. Methods: 363 participants were included and genotyped for 11 SNPs for ITGAV and 11 for ITGB8 gene. SNPs were tested for associations with the 6-month outcome after TBI, the presence of a hemorrhagic event after TBI, and the initial TBI severity after adjustment for TBI's main predictors. Results: The ITGAV rs3911239 CC and rs7596996 GG genotypes were associated with an unfavorable outcome after TBI, compared to the TT and AA genotypes, respectively. The ITGB8 rs10239099 CC and rs3757727 CC genotypes were associated with increased risk of any cerebral hemorrhagic event after TBI compared to GG and TT respectively. The ITGAV rs7589470 and rs7565633 were associated with the TBI's initial severity. Conclusions: ITGAV gene SNPs may be implicated in the outcome after TBI, as well as in the initial TBI severity, and also of ITGB8 gene SNPs in the risk of hemorrhagic event after a TBI.
- Published
- 2019
- Full Text
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