62 results on '"Karakaş Ö"'
Search Results
2. AB1586-HPR REASONS FOR STOPPING HYDROXYCHLOROQUINE: DO WE GIVE UP EASILY?
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Armagan, B., primary, Konak, H. E., additional, Atalar, E., additional, Özdemir Ulusoy, B., additional, Akyüz Dağli, P., additional, Karakaş, Ö., additional, Esmer, S., additional, Apaydin, H., additional, Eksin, M. A., additional, Polat, B., additional, Kocak Ulucaköy, R., additional, Kayacan Erdoğan, E., additional, Güven, S. C., additional, Orhan, K., additional, Dogan, İ., additional, Babaoglu, H., additional, and Maraş, Y., additional
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- 2024
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3. AB1327 VALIDATION OF THE 2022 ACR/EULAR CLASSIFICATION CRITERIA FOR LARGE-VESSEL VASCULITIS; CONFUSION OF CLASSIFICATION BETWEEN CERTAIN AGES REMAINS
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Özdemir Ulusoy, B., primary, Erden, A., additional, Güven, S. C., additional, Armagan, B., additional, Kayacan Erdoğan, E., additional, Akyüz Dağli, P., additional, Karakaş, Ö., additional, Omma, A., additional, Küçükşahin, O., additional, Erten, S., additional, and Babaoglu, H., additional
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- 2024
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4. AB0950 DRUG SURVIVAL AND PREDICTOR FACTORS OF DISCONTINUATION IN AXIAL SPONDYLOARTHRITIS PATIENTS RECEIVING CERTOLIZUMAB AND SECUKINUMAB
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Atalar, E., primary, Konak, H. E., additional, Akyüz Dağli, P., additional, Özdemir Ulusoy, B., additional, Karakaş, Ö., additional, Orhan, K., additional, Kocak Ulucaköy, R., additional, Kayacan Erdoğan, E., additional, Güven, S. C., additional, Küçükşahin, O., additional, Dogan, İ., additional, Babaoglu, H., additional, Maraş, Y., additional, Erten, S., additional, Omma, A., additional, and Armagan, B., additional
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- 2024
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5. AB0724 TOFACITINIB DRUG SURVIVAL MAY BE BETTER IN OBESE TNF INHIBITOR RESISTANT RA PATIENTS
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Kayacan Erdoğan, E., primary, Armagan, B., additional, Kocak Ulucaköy, R., additional, Orhan, K., additional, Güven, S. C., additional, Özdemir Ulusoy, B., additional, Konak, H. E., additional, Karakaş, Ö., additional, Akyüz Dağli, P., additional, Atalar, E., additional, Dogan, İ., additional, Maraş, Y., additional, Omma, A., additional, Küçükşahin, O., additional, Erten, S., additional, and Babaoglu, H., additional
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- 2024
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6. Monotonic mechanical properties of titanium grade 5 (6Al-4V) welds made by microplasma
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Szusta, J., Tüzün, N., and Karakaş, Ö.
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- 2019
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7. Critical distance approach for the fatigue strength assessment of magnesium welded joints in contrast to Neuber's effective stress method
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Karakaş, Ö., Zhang, G., and Sonsino, C.M.
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- 2018
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8. POS1274 A SINGLE CENTER COVID-19 VACCINE EXPERIENCE IN FAMILIAL MEDITERRANEAN FEVER PATIENTS
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Güven, S. C., primary, Karakaş, Ö., additional, Atalar, E., additional, Konak, H. E., additional, Akyüz Dağli, P., additional, Kayacan Erdogan, E., additional, Armagan, B., additional, Gok, K., additional, Dogan, I., additional, Maraş, Y., additional, Erden, A., additional, Erten, S., additional, Küçükşahin, O., additional, and Omma, A., additional
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- 2022
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9. AB1175 EFFECTS OF THE COVID-19 DISEASE ON AXIAL SPONDYLOARTHRITIS DISEASE FLARE
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Armagan, B., primary, Atalar, E., additional, Özdemir, B., additional, Karakaş, Ö., additional, Kayacan Erdogan, E., additional, Güven, S. C., additional, Dogan, I., additional, Küçükşahin, O., additional, and Erden, A., additional
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- 2022
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10. POS1250 EVALUATION AFTER COVID-19 VACCINATION IN PATIENTS WITH ANTIPHOSPHOLIPID SYNDROME: A RETROSPECTIVE COHORT STUDY.
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Karakaş, Ö., primary, Erden, A., additional, Armagan, B., additional, Güven, S. C., additional, Atalar, E., additional, Polat, B., additional, Omma, A., additional, and Küçükşahin, O., additional
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- 2022
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11. AB0314 SEMAPHORIN 3A LEVELS IN LUPUS WITH AND WITHOUT SECONDARY ANTIPHOSPHOLIPID ANTIBODY SYNDROME AND RENAL INVOLVEMENT
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Kart-Bayram, G. S., primary, Bayram, D., additional, Erden, A., additional, Güven, S. C., additional, Özdemir, B., additional, Apaydin, H., additional, Omma, A., additional, Karakaş, Ö., additional, Armagan, B., additional, Gok, K., additional, Maraş, Y., additional, Ateş, O., additional, Topçuoğlu, C., additional, Küçükşahin, O., additional, and Erten, S., additional
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- 2021
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12. AB0157 PREVALENCE OF SARCOPENIA AND CLINICAL IMPLICATIONS IN NEWLY DIAGNOSED RHEUMATOID ARTHRITIS PATIENTS
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Ekici, R., primary, Erden, A., additional, Özdemir, B., additional, Güven, S. C., additional, Armagan, B., additional, Karakaş, Ö., additional, Gok, K., additional, Omma, A., additional, Küçükşahin, O., additional, and Erten, S., additional
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- 2021
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13. Fatigue design of welded joints from the wrought magnesium alloy AZ31 by the local stress concept with the fictitious notch radii of rf = 1.0 and 0.05 mm
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Karakas, Ö., Morgenstern, C., and Sonsino, C.M.
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- 2008
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14. Corrigendum to “Monotonic mechanical properties of titanium grade 5 (6Al-4V) welds made by microplasma” [Theoret. Appl. Fract. Mech. 100 (2019) 27–38]
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Szusta, J., Tüzün, N., and Karakaş, Ö.
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- 2020
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15. LID - 10.3390/ma11122544 [doi]
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Szusta JAUID- ORCID: 0000-0002-0574-7133, Tomczyk A, and Karakaş Ö
- Abstract
The paper presents an original method for estimating the shrink sleeve label compressive force on packaging. One of the most popular methods of measuring deformations was used, i.e., the electrical resistance strain gauge measurement. It was assumed that the packaging was a thin-walled axially symmetrical vessel. The packing walls on one side are loaded with internal pressure generated by heating the liquid contained inside the packaging. On the other side, the film shrinking on the packaging generates additional deformation. By measuring the changes in circumferential deformations in the shrinking process at various packaging heights, it is possible to infer the uniformity of the film compressive force. Results of research on changes of these deformations over time with different intensity values of the shrinkage medium were presented.
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- 2018
16. The effect of welding defects to the tensile behavior in corrosive environment of AISI 304L stainless steel joined with shielded metal electrode
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Türkan, M., primary and Karakaş, Ö., additional
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- 2017
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17. Intravenous treatment adherence of patients with chronic inflammatory rheumatic diseases during the COVID-19 pandemic: experience of a single center
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Konak Hatice Ecem, Armağan Berkan, Güven Serdar Can, Atalar Ebru, Karakaş Özlem, Esmer Serdar, Eksin Mehmet Akif, Polat Bünyamin, Apaydin Hakan, Gök Kevser, Doğan İsmail, Erden Abdulsamet, Maraş Yüksel, Küçükşahin Orhan, Omma Ahmet, and Erten Şükran
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coronavirus ,infliximab ,intravenous infusion ,patient adherence ,rheumatology ,rituximab ,Internal medicine ,RC31-1245 - Abstract
Introduction: Patients with chronic inflammatory rheumatic diseases (CIRD) who receive intravenous therapy requiring hospitalization are likely to be more affected than those with receiving oral therapy during COVID-19 pandemic. We aimed to investigate the effect of the COVID-19 pandemic on adherence to treatment in patients with CIRD receiving intravenous treatments.
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- 2022
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18. COMPARISON OF METHOTREXATE AND AZATHIOPRINE AS THE FIRST STEROID-SPARING IMMUNOSUPPRESSIVE AGENT IN PATIENTS WITH TAKAYASU'S ARTERITIS.
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Tahra, S. Kaymaz, Bayindir, O., Ince, B., Isik, O. Ozdemir, Kutu, M. E., Karakaş, Ö., Yildirim, T. Demirci, Ademoğlu, Z., Ediboglu, E. Durak, Uludogan, B. C., Ilgin, C., Bilge, N. S. Yasar, Kaşifoğlu, T., Akar, S., Emmungil, H., Onen, F., Omma, A., Kanıtez, N. A., Yazici, A., and Cefle, A.
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- 2023
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19. INVESTIGATION OF FACTORS ASSOCIATED WITH PET/CT EXPERIENCE AND DIAGNOSTIC VALUE IN RHEUMATOLOGY PRACTICE.
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Dağlı, P. Akyüz, Güven, S. C., Coşkun, N., Karakaş, Ö., Armagan, B., Gok, K., Dogan, I., Maraş, Y., Türkölmez, Ş., and Erten, S.
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- 2023
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20. Monotonic and low cycle fatigue behaviour of 2024‐T3 aluminium alloy between room temperature and 300 °C for designing VAWT components
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Karakaş, Ö., primary and Szusta, J., additional
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- 2015
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21. On semi-automated matching and integration of database schemas
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Ünal Karakaş, Ö., Afsarmanesh Tehrani, Hamideh, and Federated Collaborative Networks (IVI, FNWI)
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- 2010
22. Monotonic and low cycle fatigue behaviour of 2024-T3 aluminium alloy between room temperature and 300 °C for designing VAWT components.
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Karakaş, Ö. and Szusta, J.
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- *
ALUMINUM alloy fatigue , *HIGH temperatures , *CYCLIC fatigue , *MATERIAL fatigue - Abstract
In the present study, the results of the monotonic tension tests and low cycle fatigue tests performed on aluminium alloy EN AW-2024-T3 under various operating temperatures are presented in order to assess the fatigue behaviour of the aluminium alloy under evaluated temperatures. Monotonic tests were performed to determine the influence of temperature on mechanical properties of the material. The aim of cyclic tests was to acquire the parameters required for Manson-Coffin equation in order to plot strain-fatigue life curves. Moreover, stress-strain behaviour of the alloy and the cyclic hardening behaviour were evaluated using Ramberg-Osgood equation. Finally, PSWT-damage parameters for each temperature have been calculated for further investigation of the effects of the temperature on fatigue life using acquired data while taking the account of mean stress effect into calculations. Variations in the experimental data due to various test temperatures are presented for both monotonic and cyclic tests. [ABSTRACT FROM AUTHOR]
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- 2016
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23. The effects of yeast culture products on fattening performance, rumen papilla morphology, some blood and rumen fluid parameters in saanen male kids
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KARAKAŞ OĞUZ F, BUĞDAYCI KE, OĞUZ MN, ALBAY MK, ŞAHİNDURAN Ş, ÖNER J, and GÜMÜŞ H
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Veterinary medicine ,SF600-1100 - Published
- 2015
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24. Assessment of barley (Hordeum vulgare L.) mature embryos for Agrobacterium-mediated transformation
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Karakaş, Ö, Cüneyt Uçarlı, Gözükirmizi, N., and Gürel, F.
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Hordeum vulgare L.,Agrobacterium-mediated transformation,mature embryo - Abstract
This study describes a protocol for Agrobacterium-mediated transformation of barley mature embryos. Cultured embryos were co-cultivated by EHA 105 strain carrying pCambia2301 binary vector and assayed for transient GUS expression. After 3 days of transformation, GUS expressing spots have been observed over 20.3% of total embryos. Among the tested several pre-treatments, infiltration in a vacuum chamber (400 mm Hg for 20 min) and infection by AGL-1 strain instead of EHA 105 increased the numbers of embryos with GUS staining significantly (p
25. Obesity might not alter tofacitinib drug survival in rheumatoid arthritis patients.
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Kayacan Erdoğan E, Armağan B, Koçak Ulucaköy R, Orhan K, Can Güven S, Özdemir Ulusoy B, Konak HE, Karakaş Ö, Akyüz Dağlı P, Atalar E, Doğan İ, Maraş Y, Omma A, Küçükşahin O, Erten Ş, and Babaoğlu H
- Abstract
Introduction: Obese rheumatoid arthritis (RA) patients often show reduced responses to traditional treatments, including TNF inhibitors (TNFi). Considering the different mechanisms of action it is important to evaluate the efficacy of tofacitinib in obese patients. This study aims to explore the impact of obesity on the drug survival of tofacitinib in RA patients., Material and Methods: This retrospective cohort study included RA patients treated with tofacitinib. Patients were categorized into obese (BMI ≥ 30 kg/m
2 ) and non-obese (BMI < 30 kg/m2 ) groups. The primary outcome was drug survival, assessed using Kaplan-Meier and logistic regression analyses., Results: The study comprised 80 RA patients, with 31 (39%) classified as obese. At the 12-month mark, the drug survival rate for tofacitinib was higher in the obese group (81%) compared to the non-obese group (59%). Contrary to univariable analysis, multivariate analysis did not identify obesity as a significant predictor of drug survival. Other variables including sex, hypertension, diabetes mellitus, and anti-cyclic citrullinated peptide (anti-CCP) positivity also showed no significant association with tofacitinib drug survival., Conclusion: The findings indicate that obesity does not alter the drug survival rate for tofacitinib among RA patients. Univariate analysis reported a potentially higher drug survival rate in obese patients; however, the lack of statistical significance in multivariate analysis and the study's retrospective nature necessitate further research to validate these observations and guide personalized therapeutic strategies for this population., (© 2024. The Author(s), under exclusive licence to Springer-Verlag GmbH Austria, part of Springer Nature.)- Published
- 2024
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26. Low relapse rate in patients with giant cell arteritis in a multi-centre retrospective Turkish Registry.
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Alibaz-Öner F, Kelesoglu B, Balci MA, Yardimci GK, Armağan B, Kiliç L, Karakaş Ö, Erden A, Yasar Bilge S, Kardaş RC, Küçük H, Zengin O, Tasci M, Kocaer SB, Yavuz S, Dogru A, Şahin M, Bayindir O, Sevik G, Ertürk Z, Alpay-Kanitez N, Gogebakan H, Tezcan ME, Oksuz MF, Cefle A, Kucuksahin O, Yazici A, Kasapoglu E, Bes C, Unal AU, Dalkiliç E, Yildirim Çetin G, Aksu K, Keser G, Onen F, Çobankara V, Kisacik B, Onat AM, Öztürk MA, Kaşifoğlu T, Omma A, Karadag O, Ates A, and Direskeneli H
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- Humans, Retrospective Studies, Female, Aged, Male, Turkey, Middle Aged, Treatment Outcome, Remission Induction, Time Factors, Immunosuppressive Agents therapeutic use, Aged, 80 and over, Giant Cell Arteritis drug therapy, Giant Cell Arteritis diagnosis, Recurrence, Registries, Glucocorticoids therapeutic use, Glucocorticoids administration & dosage
- Abstract
Objectives: Glucocorticoids (GC) are widely accepted as the standard first-line treatment for giant cell arteritis (GCA). However, relapse rates are reported up to 80% on GC-only protocol arms in controlled trials of tocilizumab and abatacept in 12-24 months. Herein, we aimed to assess the real-life relapse rates retrospectively in patients with GCA from Turkey., Methods: We assembled a retrospective cohort of patients with GCA diagnosed according to ACR 1990 criteria from tertiary rheumatology centres in Turkey. All clinical data were abstracted from medical records. Relapse was defined as any new manifestation or increased acutephase response leading to the change of the GC dose or use of a new therapeutic agent by the treating physician., Results: The study included 330 (F/M: 196/134) patients with GCA. The mean age at disease onset was 68.9±9 years. The most frequent symptom was headache. Polymyalgia rheumatica was also present in 81 (24.5%) patients. Elevation of acute phase reactants (ESR>50 mm/h or CRP>5 mg/l) was absent in 25 (7.6%) patients at diagnosis. Temporal artery biopsy was available in 241 (73%) patients, and 180 of them had positive histopathological findings for GCA. For remission induction, GC pulses (250-1000 methylprednisolone mg/3-7 days) were given to 69 (20.9%) patients, with further 0.5-1 mg/kg/day prednisolone continued in the whole group. Immunosuppressives as GC-sparing agents were used in 252 (76.4%) patients. During a follow-up of a median 26.5 (6-190) months, relapses occurred in 49 (18.8%) patients. No confounding factor was observed in relapse rates. GC treatment could be stopped in only 62 (23.8%) patients. Additionally, GC-related side effects developed in 64 (24.6%) patients, and 141 (66.2%) had at least one Vasculitis Damage Index (VDI) damage item present during follow-up., Conclusions: In this first multi-centre series of GCA from Turkey, we observed that only one-fifth of patients had relapses during a mean follow-up of 26 months, with 76.4% given a GC-sparing IS agent at diagnosis. At the end of follow-up, GC-related side effects developed in one-fourth of patients. Our results suggest that patients with GCA had a low relapse rate in real-life experience of a multi-centre retrospective Turkish registry, however with a significant presence of GC-associated side effects during follow-up.
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- 2024
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27. Non-criteria autoantibodies in antiphospholipid syndrome may be associated with underlying disease activity.
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Akyüz Dağlı P, Erden A, Babaoğlu H, Karakaş Ö, Özdemir Ulusoy B, Konak HE, Armağan B, Erten Ş, and Omma A
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- Female, Pregnancy, Humans, Autoantibodies, Antibodies, Antiphospholipid, Antibodies, Anticardiolipin, beta 2-Glycoprotein I, Immunoglobulin M, Immunoglobulin G, Immunoglobulin A, Antiphospholipid Syndrome complications, Antiphospholipid Syndrome diagnosis, Lupus Erythematosus, Systemic complications
- Abstract
Background: Antiphospholipid syndrome (APS) is a systemic autoimmune disorder characterized by persistent antiphospholipid antibodies (aPLs) with arterial and venous thrombosis and/or pregnancy morbidity. In recent years, several studies have highlighted the potential role of non-criteria aPL in diagnosing APS patients., Aim: This study aimed to determine the association of the presence of non-criteria aPL antibodies to the clinical and laboratory features of patients with a diagnosis of APS., Methods: Eighty patients diagnosed with APS and under observation in the rheumatology clinic of Ankara City Hospital were assessed. Patient demographic and clinical features were meticulously recorded. Non-criteria antibodies tested in our center included antiphosphatidylserine IgA, antiphosphatidylserine IgM, beta 2 glycoprotein IgA, anti-cardiolipin IgA, antiphospholipid antibody IgG, and antiphospholipid antibody IgM. Antibodies from patients who were tested for at least one non-criteria antibody were documented., Results: Out of 80 patients, 55 (68.8%) were tested for at least one non-criteria antibody, and 29 of those patients (52.7%) tested positive for at least one non-criteria antibody. The antiphospholipid antibody IgM and the beta 2 glycoprotein IgA were the most commonly tested non-criteria antibodies. Patients with non-criteria antibody positivity had a higher frequency of Ds DNA positivity and low complement (62.0% vs. 35.0%, p = 0.042; 69.0% vs. 38.0%, p = 0.023), respectively. In addition, positivity for anti-cardiolipin IgG and b2 glycoprotein IgG was significantly higher in the group positive for non-criteria antibodies (79% vs. 31%, p ≤ 0.001; 72.0% vs. 19%, p ≤ 0.001). There was no significant difference between the clinical features of patients with at least one positivity for non-criteria antibodies and those without., Conclusion: Systemic lupus erythematosus (SLE) is the most commonly associated disease with APS, being present in approximately 35% of cases [1]. Since the majority of the patient group in our study had APS that was secondary to SLE, non-criteria antibody positivity may be linked to the immunological activity of SLE. Large multicenter studies are necessary to investigate the clinical significance of isolated/combined positivity for criterion/non-criteria aPLs., (© 2023. The Author(s), under exclusive licence to Royal Academy of Medicine in Ireland.)
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- 2024
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28. Effect of Welding Process Parameters on the Strength of Dissimilar Joints of S355 and Strenx 700 Steels Used in the Manufacture of Agricultural Machinery.
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Szusta J, Derpeński Ł, Karakaş Ö, Tüzün N, and Dobrzański S
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The paper evaluates the possibility of using dissimilar materials joined by welding technology in the construction of agricultural machinery. The desire to design larger and more efficient structures requires designers to combine materials with different mechanical and structural properties. In such a case, it is very important to properly select welding parameters so that, on the one hand, the quality of the joint meets the standard requirements, and on the other, the welding process is not too energy-intensive. In this paper, overlay joints connecting S355 steel with Strenx 700 steel were analyzed in terms of strength for three different values of welding parameters and different thicknesses. The starting point was the reference parameters recommended by the company's welding technologists, which were reduced by 10 and 20% according to the linear welding energy. The study compared the strength, ductility and macrostructure of the joints, as well as the energy intensity of the process. The proposed dissimilar joints achieved approximately a 10% increase in the strength limit of the components in comparison to the previously recommended welding parameters. Additionally, finite element analysis calculations of the improved designs showed significant weight reduction (up to 40%) for the relevant agricultural machinery components.
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- 2023
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29. Rheumatology experience with FDG PET / CT in inflammation of unknown origin: a single - centre report for determining factors associated with diagnostic precision.
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Akyüz Dağlı P, Güven SC, Coşkun N, Karakaş Ö, Armağan B, Orhan K, Doğan İ, Maraş Y, Türkölmez Ş, and Erten Ş
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- Humans, Male, Retrospective Studies, Positron-Emission Tomography, Inflammation diagnostic imaging, Positron Emission Tomography Computed Tomography methods, Radiopharmaceuticals, Fluorodeoxyglucose F18, Rheumatology
- Abstract
BACKGROUND / AIM: The use of PET / CT is becoming more common in the elucidation of inflammatory processes in which the underlying cause cannot be determined by conventional examinations. Although PET / CT is an effective method for detecting inflammatory foci, the precise diagnosis may not be obtained in all cases. In addition, considering factors such as radiation exposure and cost, it becomes important to identify patients who can get results with PET / CT. In this study, it was aimed to examine the factors that can predict the differential diagnostic value of PET / CT by retrospectively scanning patients who underwent PET / CT for inflammation of unknown origin (IUO) in rheumatology practice., Methods: Demographic, clinical and laboratory information of the patients followed up in our clinic and who underwent PET / CT for differential diagnosis were enrolled. Whether they were diagnosed after PET / CT and during the follow - up period, and their diagnoses were examined., Results: A total of 132 patients were included in the study. A previous diagnosis of rheumatic disease was present in 28.8 % of the patients, and a history of malignancy was present in 2.3 % . The patients were divided into three groups: group 1 patients with increased FDG uptake in PET / CT and diagnosis confirmed by PET / CT, group 2 patients with increased FDG uptake in PET / CT but diagnosis was not confirmed, and group 3 patients without increased FDG uptake in PET / CT. Increased FDG uptake in PET / CT was detected in 73 % of the patients. While PET / CT helped the diagnosis in 47 (35.6 %) patients (group 1), it did not help the diagnosis in 85 (64.4 %) (groups 2 and 3). Thirty - one (65.9 %) of the diagnosed patients were diagnosed with a rheumatologic disease. When the 3 groups were compared, male gender, advanced age, CRP levels, presence of constitutional symptoms, SUVmax values and number of different organs with increased FDG uptake were higher in Group 1. Sixty - six percent and 74 % of the patients in groups 2 and 3 were not diagnosed during the follow - up period. No patient in group 3 was diagnosed with malignancy during follow - up., Conclusion: PET / CT has high diagnostic value when combined with clinical and laboratory data in the diagnosis of IUO. Our study revealed that various factors can affect the diagnostic value of PET / CT. Similar to the literature, the statistically significant difference in CRP levels shows that patients with high CRP levels are more likely to be diagnosed with an aetiology in PET / CT. Although detection of involvement in PET / CT is not always diagnostic, there was an important finding that no malignancy was detected in the follow - up in any patient without PET / CT involvement. Key points • PET / CT is an effective method for detecting inflammatory foci. • PET / CT has proven to be effective in the diagnosis of rheumatological diseases, the extent of disease and the evaluation of response to treatment. • Indications for the use of PET / CT in the field of rheumatology and the associated factors and clinical features supporting the diagnosis with PET / CT are still to be fully clarified. • In routine practice, with PET / CT, both delays in diagnosis and examinations performed during diagnosis and the cost can be reduced., (© 2023. International League of Associations for Rheumatology (ILAR).)
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- 2023
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30. The Possible Relation of Demodex and Facial Erythema in Connective Tissue Diseases.
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Erden A, Armağan B, Güven SC, Karakaş Ö, Erden F, Özdemir B, Omma A, and Küçükşahin O
- Abstract
Background: We aimed to investigate the frequency of Demodex infestation and clinical implications in connective tissue disease patients with facial erythema., Methods: Patients diagnosed with a connective tissue disease and had facial erythema were consecutively enrolled in the study from 2019-2020. An age and gender matched control group was formed from healthy volunteers. Presence of Demodex was investigated by standardized skin surface biopsy. Number of Demodex mites over 5 per centimeter square was considered meaningful for infestation. Topical or systemic metronidazole treatment was given to the connective tissue disease patients with Demodex infestation. Facial erythema visual analog scale was questioned in patients at treatment onset and one month after., Results: A total of 31 connective tissue disease patients with facial erythema were enrolled. Control group included 31 healthy volunteers. Demographics and comorbidities were similar between groups. Demodex infestation was present in 58.1% of the disease group and in 25.8% of the control group ( P =0.01). Pruritus was the most common symptom in patients with infestation. Median (IQR) facial erythema visual analog scale score was 6 (3) at treatment onset and was 2 (2.5) one month later ( P <0.001)., Conclusion: When evaluating facial cutaneous lesions, Demodex infestation should not be overlooked in a patient group like connective tissue diseases with dysfunctional immune system., Competing Interests: Conflicts of interest The authors declare no conflicts of interest., (Copyright © 2023 Erden et al. Published by Tehran University of Medical Sciences.)
- Published
- 2023
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31. Evaluation of patients with antiphospholipid syndrome subsequently COVID-19 vaccinations: A retrospective cohort study.
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Karakaş Ö, Erden A, Armağan B, Güven SC, Atalar E, Polat B, Omma A, and Küçükşahin O
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- Female, Humans, Pregnancy, BNT162 Vaccine, Drug-Related Side Effects and Adverse Reactions, Retrospective Studies, Vaccination adverse effects, Antiphospholipid Syndrome diagnosis, Antiphospholipid Syndrome epidemiology, COVID-19 epidemiology, COVID-19 prevention & control, COVID-19 Vaccines adverse effects, Pregnancy Complications, Infectious
- Abstract
The aim of this study is to evaluate development of side effects, thrombotic or obstetric complications in our antiphospholipid syndrome (APS) patient group, after vaccination against coronavirus disease 2019 (COVID-19). A cohort was formed from patients who have previously been followed up with a diagnosis of APS. The patients of the cohort were evaluated retrospectively to find out if they were vaccinated with CoronaVac and/or BNT162b2 vaccines which are being used in our country. To evaluate the side effects seen after the vaccination, the information was collected by the patients in their outpatient appointments or making a phone call. Thirty-five APS patients who had received at least 1 dose of any of the COVID-19 vaccines were included in the study. Median (min-max) number of vaccine doses per patient was 2 (1-3). Eleven patients had a booster dose after primary vaccination. Twenty patients were ever vaccinated with BNT162b2 and 18 with CoronaVac. Among BNT162b2 recipients, 9 (45.0%) and among CoronaVac recipients 15 (42.9%) reported an adverse event after a vaccine administration. The most common adverse events were myalgia and malaise after any dose of both vaccines. No vaccine-related new thrombotic events or APS flares were observed. Our results were comparable with those reported in the literature. Comprehensive large-scale studies are needed for more accurate results on the evaluation of side effects after COVID-19 vaccination in APS patients., (© 2022 Asia Pacific League of Associations for Rheumatology and John Wiley & Sons Australia, Ltd.)
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- 2023
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32. Enzymatic determination of hypoxanthine in fish samples as a freshness indicator using the CUPRAC colorimetric sensor.
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Avan AN, Karakaş Ö, Demirci-Çekiç S, and Apak R
- Subjects
- Animals, Humans, Hypoxanthine analysis, Antioxidants metabolism, Ascorbic Acid, Uric Acid analysis, Colorimetry, Hydrogen Peroxide
- Abstract
Fish consumption is essential for a healthy diet. However, all seafood including fish are susceptible to deterioration unless properly preserved. Controlling the freshness of fresh or packaged fish is a challenging issue for the food industry in terms of human health and shelf life determination. One of the main indicators showing the freshness of fish is undoubtedly the amount of hypoxanthine (Hx). As soon as the organism dies, Hx begins to be released with the cessation of ATP synthesis and shows a gradual increase over time. Therefore, Hx determination is an important indicator in the control of fish freshness. Based on this fact, a colorimetric method for the enzymatic determination of Hx using the CUPRAC (Cupric ion Reducing Antioxidant Capacity) sensor was developed. Uric acid (UA) and H
2 O2 are enzymatically produced by xanthine oxidase (XOD) from Hx, and both products respond to the CUPRAC reagent to produce the cuprous neocuproine (Cu(I)-Nc) chromophore chelate formed in situ on a Nafion anionic membrane on which the cationic Cu(II)-Nc complex was fixed. Hx was measured at different time intervals in the meat samples taken from sea bass (Dicentrarchus labrax), which was left to stand at room temperature for a time period between 0 and 24 h; the level of spoilage was determined from the coloration of the CUPRAC membrane sensor (via absorbance measurement at 450 nm). It was observed that there was a linear increase in the amount of Hx during the measurement period. The method was optimized for Hx determination, verified with interference analysis and standard additions to real samples, and validated against HPLC. The linear detection range of the developed method for Hx was 2.0-32.0 μM with an LOD of 0.79 μM, and early stages of fish degradation could be detected at several nanomoles of Hx per gram of fish meat. The proposed method was demonstrated to have distinct superiority over many recent colorimetric sensors of fish freshness in regard to its lower LOD for Hx, wider linear range, capability to cope with interferents (including biologically important antioxidants, such as cysteine, reduced glutathione, ascorbic acid, UA and α-tocopherol) and applicability to real samples., Competing Interests: Conflict of interest The authors declare no conflict of interest., (Copyright © 2022 Elsevier Inc. All rights reserved.)- Published
- 2023
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33. Comparison of anakinra and tocilizumab in management of severe COVID-19: a retrospective cohort study.
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Küçükşahin O, Erden A, Karakaş Ö, Güven SC, Armağan B, Şahiner EŞ, İnan O, Kurtipek AC, Gemcioğlu E, Karaahmetoğlu S, Turan S, İzdeş S, Erdem D, Aypak A, Ayhan M, Akıncı E, Bodur H, Güner R, Omma A, and Ateş İ
- Subjects
- Humans, Retrospective Studies, Cross-Sectional Studies, Cohort Studies, Interleukin 1 Receptor Antagonist Protein therapeutic use, COVID-19 Drug Treatment
- Abstract
Background: Studies regarding effectiveness of anakinra and tocilizumab treatments in coronavirus disease 2019 (COVID-19) have contradictory results. Furthermore, there is scarce comparative data regarding superiority of any agent. To further elucidate any superiority between these two agents, we retrospectively investigated and compared outcomes in hospitalized COVID-19 patients of our inpatient cohort who received anakinra or tocilizumab., Methods: This study was designed as a single-center, retrospective, cross-sectional cohort study. Hospitalized patients with confirmed diagnosis of COVID-19 who had Brescia-COVID respiratory severity scale score ≥3 and hyperinflammation (defined as elevation of C reactive protein ≥50 g/L or ferritin ≥700 ng/mL) and received anakinra or tocilizumab in addition to standard care were enrolled in the study. Length of hospital stay after initiation of antiinflammatory treatment, need for mechanical ventilation, need for intensive care unit admission, mortality were set as primary outcomes and compared between tocilizumab and anakinra recipients after propensity score matching., Results: One hundred and six patients were placed in each group after propensity score matching. In the anakinra group, relative risk reduction for intensive care unit admission was 50% when compared to the tocilizumab group and the number needed to treat to avert an intensive care unit admission was 3 (95% CI, 2-5). In terms of mortality, a 52% relative risk reduction was observed with anakinra treatment and the number needed to treat to avert an intensive care unit admission was 8 (95% CI, 4-50). Significantly more patients were observed to receive glucocorticoids in the anakinra group., Discussion: Anakinra administration in severe COVID-19 patients was significantly associated with better survival and greater clinical improvement compared to the tocilizumab administration in our study. Increased rate of glucocorticoid use in the anakinra group might have contributed to better outcomes.
- Published
- 2022
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34. Performance of the systemic lupus erythematosus risk probability index in a cohort of undifferentiated connective tissue disease.
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Erden A, Apaydın H, Fanouriakis A, Güven SC, Armagan B, Akyüz Dağlı P, Konak HE, Polat B, Atalar E, Esmer S, Karakaş Ö, Özdemir B, Eksin MA, Omma A, Kücüksahin O, Bertsias GK, and Boumpas DT
- Subjects
- Cohort Studies, Humans, Probability, Connective Tissue Diseases complications, Connective Tissue Diseases diagnosis, Lupus Erythematosus, Systemic complications, Lupus Erythematosus, Systemic diagnosis, Undifferentiated Connective Tissue Diseases
- Abstract
Objectives: We sought to evaluate the performance of the SLE Risk Probability Index (SLERPI) for identification of SLE in a large cohort of patients with UCTD., Methods: The SLERPI was applied in a cohort of patients who met classification criteria for UCTD and did not fulfil any classification criteria for other defined CTD including SLE. Patients with a SLERPI score of >7 were 'diagnosed' as SLE. Patients diagnosed with SLE and those not were compared in terms of disease characteristics and index parameters., Results: A total of 422 patients with UCTD were included in the study. Median (interquartile range) SLERPI was 4.25 (2.5) points, while 39 (9.2%) patients had a SLERPI score >7 and were diagnosed as SLE. Patients with younger age (P = 0.026) and presence of malar rash (P < 0.0001), mucosal ulcer (P < 0.0001), alopecia (P < 0.0001), ANA positivity (P < 0.0001), low C3 and C4 (P = 0.002), proteinuria >500 mg/24 h (P = 0.001), thrombocytopenia (P = 0.009) or autoimmune haemolytic anaemia (P < 0.0001) were more likely to fulfil criteria for SLE by the SLERPI., Conclusion: SLERPI enabled a significant proportion of patients to be identified as SLE in our UCTD cohort. This new probability index may be useful for early identification of SLE among patients with signs of CTD without fulfilling any definite criteria set., (© The Author(s) 2022. Published by Oxford University Press on behalf of the British Society for Rheumatology. All rights reserved. For permissions, please email: journals.permissions@oup.com.)
- Published
- 2022
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35. A single-center COVID-19 vaccine experience with CoronaVac and BNT162b2 in familial Mediterranean fever patients.
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Güven SC, Karakaş Ö, Atalar E, Konak HE, Akyüz Dağlı P, Kayacan Erdoğan E, Armağan B, Gök K, Doğan İ, Maraş Y, Erden A, Erten Ş, Küçükşahin O, and Omma A
- Subjects
- Colchicine therapeutic use, Humans, BNT162 Vaccine adverse effects, COVID-19 epidemiology, COVID-19 prevention & control, COVID-19 Vaccines adverse effects, Familial Mediterranean Fever drug therapy
- Abstract
Aim: To determine frequency of adverse events and attacks related to vaccination in recipients of CoronaVac and BNT162b2 in familial Mediterranean fever (FMF) patients, and to search whether history of prior COVID-19 or a booster dose increases occurrence of adverse events/attacks., Methods: FMF patients were surveyed for administration of any COVID-19 vaccine and vaccine-related adverse events or FMF attacks. Demographic, clinical, vaccine-related data, history of COVID-19 infection before or after vaccination, adherence to FMF treatment during vaccination were collected., Results: A total of 161 vaccinated FMF patients were included. Ninety-three patients out of 161 had reported suffering from an adverse event/attack after a vaccine dose. There were 54.7% of BNT162b2 recipients who reported any adverse event after any vaccine dose in comparison to 29.9% of CoronaVac recipients (P < .001). There were 22.2% of BNT162b2 recipients who reported suffering from a FMF attack within 1 month after vaccination in comparison to 19.4% of CoronaVac recipients (P = .653). When patients with or without adverse event/attack were compared, no significant differences were observed in means of demographics, comorbid diseases, disease duration, total vaccine doses, or treatments adhered to for FMF. Rates of adverse events/attacks were similar between patients with and without prior COVID-19. In booster recipients, adverse events/attacks were most frequent after the booster dose., Conclusions: A considerable number of FMF patients suffered from vaccine-related adverse events/attacks, particularly with BNT162b2. No serious events or mortalities due to vaccination were detected. Demographics, clinical characteristics and prior history of vaccination did not significantly affect these results. We observed an increased rate of adverse events/attacks with booster dose administration., (© 2022 Asia Pacific League of Associations for Rheumatology and John Wiley & Sons Australia, Ltd.)
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- 2022
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36. Semaphorin 3A Levels in Lupus with and without Secondary Antiphospholipid Antibody Syndrome and Renal Involvement.
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Kart Bayram GS, Erden A, Bayram D, Özdemir B, Karakaş Ö, Apaydın H, Ateş O, Güven SC, Armağan B, Gök K, Maraş Y, Omma A, Küçükşahin O, Topçuoğlu C, and Erten Ş
- Subjects
- Female, Humans, Male, Pregnancy, Semaphorin-3A, Abortion, Spontaneous, Antiphospholipid Syndrome complications, Lupus Erythematosus, Systemic complications, Thromboembolism complications
- Abstract
Objective: The aim of this study is to evaluate semaphorin 3A levels in patients with systemic lupus erythematosus (SLE) with and without renal involvement and secondary antiphospholipid antibody syndrome (APS)., Methods: Patients with SLE were grouped according to the presence of secondary APS or renal involvement. The control group consisted of age-matched, nonsmoking, healthy volunteers. Semaphorin 3A levels were compared among groups. All patients with SLE were regrouped according to the presence of thrombotic events, miscarriages, and proteinuria, and semaphorin 3A levels were investigated. Finally, semaphorin 3A levels of all patients with SLE as a single group were compared to those of the control patients., Results: The mean semaphorin 3A values were 16.16 ± 2.84 ng/mL in the control group, 9.05 ± 5.65 ng/mL in patients with SLE without nephritis and APS, 11.28 ± 5.23 ng/mL in the SLE with APS group, and 8.53 ± 5.11 ng/mL in the lupus nephritis group. When all 3 patient groups were examined as a single group, the mean semaphorin 3A value was significantly lower than that of the control group. Semaphorin 3A was reduced in patients with SLE with thromboembolism and/or history of miscarriage., Conclusion: Semaphorin 3A levels were lower in all patient groups compared to the control group. Moreover, the reduced semaphorin 3A levels in patients with a history of thromboembolism and/or miscarriage suggest that semaphorin 3A may play an important role in the pathogenesis of vasculopathy., (© American Society for Clinical Pathology, 2021. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.)
- Published
- 2022
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37. Clinical course of idiopathic inflammatory myopathies in COVID-19 pandemic: a single-center experience.
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Apaydin H, Erden A, Güven SC, Armağan B, Karakaş Ö, Özdemir B, Polat B, Eksin MA, Omma A, and Kucuksahin O
- Abstract
Aim: To evaluate the clinical course of idiopathic inflammatory myopathy (IIM) patients in COVID-19 pandemic, and to assess the COVID-19 outcomes in infected IIM patients. Materials & methods: In this study, 39 patients were evaluated retrospectively. Myositis disease activity, myositis damage index, depression, fatigue, active medical treatment, drug compliance and SARS-CoV-2 PCR test results in COVID-19 pandemic were collected. Results: Fourteen of these patients (35%) were detected to have a positive SARS-CoV-2 PCR test. The demographic and clinical characteristics, active medical treatment, disease activity, depression and fatigue of the patients who had undergone or not SARS-CoV-2 were similar. Conclusion: Our results have shown that although prevalence of COVID-19 seems to be increased in IIM patients under immunosuppressive treatment, hospitalization rates were lower and no intensive care unit admissions or deaths were observed., (© 2022 Future Medicine Ltd.)
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- 2022
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38. COVID-19 in patients with Behçet's disease: Outcomes and rate of Behçet's exacerbations in a retrospective cohort.
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Polat B, Erden A, Güven SC, Armağan B, Karakaş Ö, Özdemir B, Apaydın H, Usul E, Ateş İ, Küçükşahin O, and Omma A
- Subjects
- Disease Progression, Humans, Retrospective Studies, SARS-CoV-2, Behcet Syndrome complications, Behcet Syndrome diagnosis, Behcet Syndrome epidemiology, COVID-19
- Abstract
Objectives: The aim of this study is to investigate the outcomes of coronavirus disease 2019 (COVID-19) in our cohort of Behçet's disease (BD) patients and to reveal the rate of BD exacerbations due to COVID-19., Methods: Patients who have been followed with a diagnosis of BD were retrospectively investigated for a positive severe acute respiratory syndrome-coronavirus 2 polymerized chain reaction (PCR) test. Data regarding demographics, clinical features and COVID-19 outcomes were collected from medical records for patients with a positive PCR. PCR-positive patients were reached via phone numbers, and 'Behçet's Disease Current Activity Form' (BDCAF) scores for pre- and post-COVID-19 BD symptoms were calculated., Results: Out of a total 648 BD patients, 59 were detected to have a positive PCR test. Three of the 59 patients (5.0%) were found to be hospitalized, none of them was admitted to the ICU or died. An increasing trend in the frequency of comorbid diseases and older age was observed in hospitalized patients. 32.2% of BD patients suffered from exacerbation of at least one symptom related to BD., Conclusions: We observed no ICU admission or mortality with COVID-19 in our BD patient cohort. A substantial number of patients suffered from exacerbation of BD symptoms., (© Japan College of Rheumatology 2022. Published by Oxford University Press. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.)
- Published
- 2022
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39. Reducing length of hospital stay with colchicine.
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Karakaş Ö, Erden A, Güven SC, Armağan B, Sahiner ES, Kurtipek AC, Inan O, Gemcioglu E, Ateş İ, Omma A, and Küçüksahin O
- Subjects
- Hospitalization, Humans, Intensive Care Units, Length of Stay, Retrospective Studies, SARS-CoV-2, COVID-19, Colchicine therapeutic use
- Abstract
Introduction: Colchicine is an ancient agent with well-known anti-inflammatory effects and commonly used in treatment of hyperinflammatory conditions. It has been argued that colchicine could be an appropriate treatment option in COVID-19 to control hyperinflammatory response. Here in this study, we aimed to investigate the impact of colchicine on outcomes of COVID-19 in our inpatient cohort., Methodology: In this retrospective cohort study, hospitalized COVID-19 patients were investigated. Demographics, comorbidities, COVID-19 symptoms, laboratory findings on admission and discharge, baseline and seventh day oxygenation status, rates of mortality, intensive care unit admission, administration of other anti-inflammatory treatments and length of hospital stay were compared between patients who received standard of care medications and who received colchicine additionally., Results: Three hundred and thirty-six patients were included in the study (171 standard of care, 165 standard of care plus colchicine). The median length of hospital stay in colchicine group was significantly shorter. Rates of admission to intensive care unit, anti-inflammatory treatment administration and mortality did not differentiate between standard of care and colchicine groups. However, reduced rates of mortality and ICU admission were observed in patients who received colchicine with a dose of 1 mg/day when compared to patients who received 0.5 mg/day., Conclusions: Our study demonstrated that COVID-19 patients who received colchicine in addition to standard of care had shorter hospital stay. Our results further support the use of colchicine in treatment of COVID-19, particularly with a dose of 1 mg/day., Competing Interests: No Conflict of Interest is declared, (Copyright (c) 2022 ozlem Karakas, Abdulsamet Erden, Serdar Can Guven, Berkan Armagan, Enes Seyda Sahiner, Ali Can Kurtipek, Osman Inan, Emin Gemcioglu, Ihsan Ates, Ahmet Omma, Orhan Kucuksahin.)
- Published
- 2022
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40. Sulfate radical formation by Cr(III) activation of peroxydisulfate - Diphenylcarbazide spectrophotometric determination of sulfate radical and its scavenging activity.
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Uzunboy S, Karakaş Ö, Demirci-Çekiç S, and Apak R
- Abstract
Even though sulfate anion radical (SO
4 - ) is a very reactive oxidant used in advanced oxidation processes, a reliably selective and simple colorimetric method for determining this radical can hardly be found. Peroxydisulfate (S2 O8 2- ) or peroxymonosulfate (HSO5 - ) can be activated with transition metal ions to produce SO4 - . We have discovered that Cr(III) can be an activator for persulfate, generating Cr(VI) along with SO4 - . By measuring the emerging chromate with diphenyl carbazide (DPC) spectrophotometry at 542 nm, we could measure both the formation of SO4 - and its scavenging with antioxidant compounds. We could also investigate a number of UV-absorbing SO4 - scavengers which could not be measured with other UV spectrometric methods. In addition to conventional antioxidants (phenolics such as quercetin, catechin, epicatechin, caffeic acid, thiols like cysteine and N-acetyl cysteine, and ascorbid acid), nitro-aromatics (represented by 2,4,6-trinitrophenol and 2,4-dinitrophenol) used in ammunition formulations could also be measured as scavengers. The presence of scavengers caused a reduction in the amount of Cr(VI) generated, where the difference in absorbance (ΔA) of chromate - with respect to the DPC method - in the absence and presence of scavengers was a linear function of SO4 - scavenging capacity. Ethanol and tert-butanol were tested as solvents to show the selectivity of the method for SO4 - . The method was statistically compared to a suitably modified ABTS/persulfate assay. The efficiency order of sulfate radical scavengers was determined and ranked (Spearman's test) using both the proposed method and modified ABTS/persulfate method to reveal a moderate correlation., Competing Interests: Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (Copyright © 2021 Elsevier B.V. All rights reserved.)- Published
- 2021
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41. Compliance to not only prone but also lateral and supine positioning improves outcome in hospitalised COVID-19 patients.
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Ateş İ, Erden A, Gürler EK, Çağlayan A, Güçbey Ö, Karakaş Ö, Şahiner ES, Güven SC, İzdeş S, Küçükşahin O, and Omma A
- Subjects
- Humans, Intensive Care Units, Prone Position, Respiration, Artificial, Retrospective Studies, SARS-CoV-2, COVID-19, Respiratory Distress Syndrome
- Abstract
Background: Positioning of the patient is a common strategy to increase oxygenation in the management of acute respiratory distress syndrome. The aim of this study is to demonstrate the effects of our positioning approach on disease outcomes in COVID-19 patients with respiratory failure, by comparing patients compliant to positioning and not., Methods: COVID-19 patients who were admitted to our internal medicine inpatient clinic and developed hypoxaemia and underwent positioning during hospital stay were retrospectively investigated for compliance to positioning. Rates of mortality, intensive care unit admission, intubation, initiation of anti-inflammatory treatment and length of hospital stay were compared between patients with and without compliance to positioning., Results: A total of 144 patients were enrolled in this study (97 compliant with positioning, 47 incompliant with positioning). Rates of ICU admission (7.2% vs 25.5%, p < .001), anti-inflammatory treatment initiation (68% vs 97.9%, p < .001) and length of hospital stay (5 (2-16) days vs 12 (3-20) days, p < .001) were significantly reduced in patients compliant with positioning., Conclusion: Prone or other positioning should be considered in patients with noninvasive oxygen support for the potential to reduce rates of intensive care unit admissions, airway interventions, anti-inflammatory treatment initiation and mortality., (© 2021 John Wiley & Sons Ltd.)
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- 2021
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42. Prevalence of sarcopenia and clinical implications in patients with newly diagnosed rheumatoid arthritis.
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Ekici R, Erden A, Güven SC, Armağan B, Özdemir B, Karakaş Ö, Gök K, Omma A, Küçükşahin O, and Erten Ş
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- Body Mass Index, Hand Strength, Humans, Muscle, Skeletal, Prevalence, Prospective Studies, Quality of Life, Arthritis, Rheumatoid complications, Arthritis, Rheumatoid diagnosis, Arthritis, Rheumatoid epidemiology, Sarcopenia diagnosis, Sarcopenia epidemiology
- Abstract
Objective: The aim of this study was to determine the frequency of sarcopenia at the time of diagnosis in patients with rheumatoid arthritis (RA), assessing disease activity and factors that may be associated with sarcopenia and observe effects of treatment on sarcopenia., Method: A prospective study was conducted with patients who have newly diagnosed RA. Patients were evaluated twice, at the time of diagnosis and 3 mo after the initiation of treatment. Demographic data, anthropometric measurements, disease activity scores, and sarcopenia status were recorded. Sarcopenia was evaluated with grip strength and bioelectric impedance. The results were compared with healthy volunteers., Results: The age at onset of RA was 50.6 ± 14.6 y. Handgrip strength (P < 0.001), skeletal muscle mass (P = 0.009), and skeletal muscle mass index (P = 0.032) were reduced in patients with RA but not in the control group. The frequency of sarcopenia in RA at onset of diagnosis was 31.5%. There was a significant decrease in the rate of sarcopenia after 3 mo of treatment (31.5 versus 8.7%; P = 0.046)., Conclusion: Sarcopenia was found in approximately one-third of the patients with newly diagnosed RA in our study. With treatment, sarcopenia improved significantly. Patients with RA should be evaluated in terms of sarcopenia in addition to evaluating joint and extraarticular findings at the time of diagnosis. Early detection and treatment planning may improve quality of life., (Copyright © 2021 Elsevier Inc. All rights reserved.)
- Published
- 2021
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43. Can Anakinra and corticosteroid treatment be an effective option in pregnant women with severe Covid-19?
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Karakaş Ö, Erden A, Ünlü S, Erol SA, Goncu Ayhan Ş, Özdemir B, Tanacan A, Ozden Tokalioglu E, Ateş İ, Moraloğlu Tekin Ö, Omma A, Şahin D, and Küçükşahin O
- Subjects
- Adrenal Cortex Hormones, Female, Humans, Pregnancy, Pregnant Women, Retrospective Studies, SARS-CoV-2, COVID-19, Interleukin 1 Receptor Antagonist Protein
- Abstract
Anakinra, which is an Interleukin-1 (IL-1) receptor antagonist with the advancing disease process, has started to be considered as an alternative treatment for Covid-19 patients with cytokine storms. We evaluated the effect of corticosteroids and IL-1 receptor blockage with anakinra on pregnant patients with Covid-19 at high risk for respiratory distress, ongoing fever, deterioration in their general condition and consequently maternal and fetal complications. Fourteen pregnant women who received anakinra (median dosage: 400 mg) and corticosteroid (methylprednisolone-median dosage: 80 mg) treatment were evaluated retrospectively. Patients were assessed according to the World Health Organization (WHO) scale. The mortality rate of the cohort was 7.1%, the median hospitalization period of the patients was 15 days and 2 patients had premature births. Covid-19 was found to have a similar spectrum of symptoms in pregnant and non-pregnant women, such as dyspnea, cough and fever. Our study was the first to analyze the combined treatment of corticosteroid and anakinra in pregnant patients with pneumonia from Covid-19 based on the WHO scoring system. Due to the obscurity in the treatment process in pregnant patients, studies are ongoing on managing Covid-19 infection in these patients. We presume that the early use of anakinra and corticosteroid treatments in patients severely infected with Covid-19 may have positive effects on disease progression and survival.
- Published
- 2021
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44. A single center experience of intravenous immunoglobulin treatment in Covid-19.
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Omma A, Erden A, Armağan B, Güven SC, Karakaş Ö, Şahiner ES, Erdem D, İzdeş S, Ateş İ, and Küçükşahin O
- Subjects
- Administration, Intravenous, Adult, Aged, Aged, 80 and over, COVID-19 diagnosis, COVID-19 mortality, COVID-19 virology, Cross-Sectional Studies, Female, Humans, Immunoglobulins, Intravenous adverse effects, Male, Middle Aged, Retrospective Studies, Severity of Illness Index, Time Factors, Treatment Outcome, Turkey, Immunoglobulins, Intravenous administration & dosage, COVID-19 Drug Treatment
- Abstract
Background: Intravenous immunoglobulins (IVIg) have been used in management of severe Covid-19. Here in this study, we report our single-center experience regarding IVIg treatment in management of severe Covid-19., Materials and Method: Among hospitalized adult Covid-19 patients between April 1 and December 31, 2020, patients with confirmed diagnosis of Covid-19 who had Brescia-COVID respiratory severity scale score ≥ 3, hyperinflammation and received IVIg treatment in addition to standard of care were retrospectively investigated. We grouped IVIg recipients into three according to reasons for IVIg administration: Group 1 patients requiring anti-inflammatory treatment but complicated with secondary infection and/or sepsis , group 2 patients with Covid-19 related complications including progressive disease refractory to other anti-inflammatory agents, myocarditis, adult multisystem inflammatory syndrome, hemophagocytic lymphohystiocytosis like syndrome and group 3 patients with other complications non-specific to Covid-19. Mortality and clinical data was compared among groups., Results: A total of 46 IVIg recipients were enrolled. Group 1 comprised 17 (36.9%), group 2 comprised 18 (39.1%) and group 3 comprised 11 (23.9%) patients. No significant differences in means of age, gender and comorbidities were observed among groups. Mortality was significantly lower in group 3 when compared to group 1 (64.7% vs 18.2%, p = 0.016) and close to significance when compared to group 2 (50% vs 18.2% p = 0.087)., Conclusions: IVIg seemed to be used mostly in severe, refractory and complicated cases in our population. As a rescue agent in severe cases refractory to other anti-inflammatory strategies, 33.7% survival rate was observed with IVIg., (Copyright © 2021 Elsevier B.V. All rights reserved.)
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- 2021
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45. COVID-19 outcomes in patients with familial Mediterranean fever: a retrospective cohort study.
- Author
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Güven SC, Erden A, Karakaş Ö, Armağan B, Usul E, Omma A, and Küçükşahin O
- Subjects
- Adult, COVID-19 mortality, Comorbidity, Cross-Sectional Studies, Familial Mediterranean Fever drug therapy, Female, Hospitalization, Humans, Intensive Care Units, Interleukin-1 antagonists & inhibitors, Length of Stay, Male, Middle Aged, Retrospective Studies, Young Adult, COVID-19 complications, Familial Mediterranean Fever complications, SARS-CoV-2
- Abstract
Aim of this study is to investigate the course of coronavirus disease 2019 (COVID-19), in our cohort of familial Mediterranean fever (FMF) patients in means of mortality, admission to hospital and/or intensive care unit and length of hospital stay.A retrospective cohort was formed from patients who have previously been followed with a diagnosis of FMF. Patients of this cohort were retrospectively evaluated for a positive severe acute respiratory syndrome-coronavirus 2 (SARS-CoV 2) polymerized chain reaction (PCR) test result and information regarding hospitalisation, intensive care unit admission and mortality were collected from medical records.Out of a total 496 FMF patients, 34 were detected to have a positive SARS-CoV 2 PCR test. Eighty-five point three percent of these patients were under colchicine treatment and 17.6% were under interleukin (IL)-1 inhibitor treatment. Eight of the 34 patients (23.9%) were found to be hospitalized, one of them was admitted to the intensive care unit and died thereafter (2.9%). An increasing trend in the frequency of comorbid diseases (presence of at least one comorbidity 64.7% in all patients vs 75.0% in hospitalized patients) and IL-1 inhibitor usage (17.6% in all patients vs 50.0% in hospitalized patients) was observed in hospitalized patients.Rates of comorbid diseases and IL-1 inhibitor use for FMF were observed to be increased in FMF patients hospitalized for COVID-19.
- Published
- 2021
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46. HPLC Detection and Antioxidant Capacity Determination of Brown, Red and Green Algal Pigments in Seaweed Extracts.
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Yalçın S, Karakaş Ö, Okudan EŞ, Başkan KS, Çekiç SD, and Apak R
- Subjects
- Carotenoids analysis, Chlorophyll analysis, Chromatography, High Pressure Liquid methods, Linear Models, Plant Extracts chemistry, Antioxidants analysis, Chlorophyta chemistry, Phaeophyceae chemistry, Pigments, Biological chemistry, Rhodophyta chemistry
- Abstract
This study was carried out to determine the main pigments in some different selected seaweeds and to reveal their antioxidant potential regarding the ever-increasing demand for utilization of marine pigments in human health and nutrition. The individual amounts of algal pigments were found by reverse phase high-performance liquid chromatography (HPLC) and their total antioxidant capacities (TAC) by two spectrophotometric TAC assays, namely: CUPRAC (CUPric ion Reducing Antioxidant Capacity) and ABTS/TEAC (2,2'-azinobis [3-ethyl benzo thiazoline-6-sulfonate])/(trolox equivalent antioxidant capacity). These two tests gave the same rank order for TAC. The TAC of HPLC-quantified compounds accounted for a relatively much lower percentage of the observed CUPRAC capacities of seaweed extracts, namely ranging from 11 to 68% for brown, from 4 to 41% for red and from 3 to 100% for green species, i.e., some TAC originated from chromatographically unidentified compounds. Fucoxanthin, chlorophyll a, and pheophytin a compounds were major pigments in brown algae. The relative carotenoid contents in red marine algae were generally lower than those of chlorophylls. Overall total quantities were quite low compared with those of brown species. In general, chlorophyll a and chlorophyll b were chiefly present in green algae, but β-carotene, violaxanthin and siphonaxanthin were also detected substantially higher in some species of green algae such as Caulerpa racemosa var. cylindracea and Codium fragile., (© The Author(s) 2020. Published by Oxford University Press. All rights reserved. For Permissions, please email: journals.permissions@oup.com.)
- Published
- 2021
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47. Load Controlled Fatigue Behaviour of Microplasma Arc Welded Thin Titanium Grade 5 (6Al-4V) Sheets.
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Szusta J, Tüzün N, and Karakaş Ö
- Abstract
The current study investigates the load controlled fatigue properties of the microplasma arc welded thin titanium Grade 5 (6Al-4V) sheets. In order to explore the effect of weld geometry on the fatigue, two different welded joints were used in the experimental studies. Load controlled fatigue test results were evaluated to present an outlook on the behaviour of microplasma welded titanium alloy Grade 5 sheets under cyclic loading. Even though the previously published monotonic tests showed successful use of microplasma arc welding to join thin titanium Grade 5 sheets with mechanical properties comparable to the base metal, fatigue life of the welded joints was lower than the lives of samples without welds. In particular, the fatigue performance of overlap joints was very poor. This was presumed to be due to the changed material properties of the heat affected zone which was formed by the excess heat of the welding process as fractures often occurred at such locations. Based on experimental findings and fractographic observations, a clear adverse effect of welding process in material behaviour was discovered. Despite the concentrated heat of microplasma arc welding, post-weld heat treatment of the weld area is recommended to improve the mechanical behaviour of the welded joints.
- Published
- 2020
- Full Text
- View/download PDF
48. Determination of Major Phytohormones in Fourteen Different Seaweeds Utilizing SPE-LC-MS/MS.
- Author
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Yalçın S, Okudan EŞ, Karakaş Ö, and Önem AN
- Subjects
- Limit of Detection, Turkey, Chromatography, High Pressure Liquid methods, Plant Growth Regulators chemistry, Plant Growth Regulators isolation & purification, Seaweed chemistry, Solid Phase Extraction methods, Tandem Mass Spectrometry methods
- Abstract
Analysis of plant growth regulators (PGRs) should be approached by considering their extremely low concentrations and serious interfering effects that result from the matrix of various plant tissues. In the current research, the separation and simultaneous determination of different classes of phytohormones in 14 seaweeds collected from Turkey seashores were achieved by using solid-phase extraction (SPE) followed by a rapid and sensitive liquid chromatography tandem mass detection method. OASIS HLB (Hydrophilic-Lipophilic Balance) cartridges were successfully used for SPE process to eliminate the matrix effect and enhance the PGRs including zeatin, benzyl amino purine, indole-3-acetic acid, abscisic acid and gibberellic acid within partially different polarities. Based on the optimized experimental conditions, the method presented excellent performance related to linearity (r, 0.9996-0.9999) within the ranges of 0.5-500 ng/mL, relative standard deviation values ((1.43-2.01) for intraday and (2.36-3.50) for interday)), the limit of detection (0.01-0.84 μg/L) and the limit of quantification (0.02-2.76 μg/L). The obtained results confirm that the SPE-liquid chromatography/tandem mass spectrometry method performed is highly effective and convenient for routine analyses of trace amounts of the tested phytohormones in seaweeds and any other plant samples as well., (© The Author(s) 2019. Published by Oxford University Press. All rights reserved. For Permissions, please email: journals.permissions@oup.com.)
- Published
- 2020
- Full Text
- View/download PDF
49. A New Method for Estimating the Clamping Force of Shrink Sleeve Labels.
- Author
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Szusta J, Tomczyk A, and Karakaş Ö
- Abstract
The paper presents an original method for estimating the shrink sleeve label compressive force on packaging. One of the most popular methods of measuring deformations was used, i.e., the electrical resistance strain gauge measurement. It was assumed that the packaging was a thin-walled axially symmetrical vessel. The packing walls on one side are loaded with internal pressure generated by heating the liquid contained inside the packaging. On the other side, the film shrinking on the packaging generates additional deformation. By measuring the changes in circumferential deformations in the shrinking process at various packaging heights, it is possible to infer the uniformity of the film compressive force. Results of research on changes of these deformations over time with different intensity values of the shrinkage medium were presented.
- Published
- 2018
- Full Text
- View/download PDF
50. Evaluation of the informed consent procedure for total knee arthroplasty patients in Turkey.
- Author
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Ekmekci PE, Ekmekci AB, Karakaş Ö, Kulduk A, and Arda B
- Subjects
- Aged, Aged, 80 and over, Female, Humans, Male, Middle Aged, Surveys and Questionnaires, Turkey, Arthroplasty, Replacement, Knee ethics, Disclosure statistics & numerical data, Informed Consent statistics & numerical data
- Abstract
Objective: The purpose of this research is to evaluate the ethical aspects of informed consent process of total knee arthroplasty (TKA) patients in Turkey., Methods: The study included 50 patients undergoing TKA in Gazi Mustafa Kemal State Hospital Orthopedics Clinic. A face to face survey was conducted to determine the ethical appropriateness of the main components of informed consent process such as; disclosure of material information about the disease and alternative treatment options, understanding the disclosed information, comprehending the written consent form and voluntariness in deciding., Results: The survey revealed that all TKA patients signed informed consent form, 80% of the participants received material information about their disease, 62% were disclosed information about TKA operation, 56% read (in personal or with the assistance of a relative) the written informed consent form, 28% received information regarding possible complications of TKA and 85% were not given any information about the alternative treatments., Conclusions: Informed consent process in TKA patients have flourished compared to previous years, but still there are some aspects in need of improvement. Using short and understandable language, developing multi-media sources and involving patients to informed consent form development process would contribute to the process., (Copyright © 2016 Turkish Association of Orthopaedics and Traumatology. Production and hosting by Elsevier B.V. All rights reserved.)
- Published
- 2016
- Full Text
- View/download PDF
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