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9. COVID-19 vaccine coverage in health-care workers in England and effectiveness of BNT162b2 mRNA vaccine against infection (SIREN): a prospective, multicentre, cohort study

Author

Hall, Victoria Jane, primary, Foulkes, Sarah, additional, Saei, Ayoub, additional, Andrews, Nick, additional, Oguti, Blanche, additional, Charlett, Andre, additional, Wellington, Edgar, additional, Stowe, Julia, additional, Gillson, Natalie, additional, Atti, Ana, additional, Islam, Jasmin, additional, Karagiannis, Ioannis, additional, Munro, Katie, additional, Khawam, Jameel, additional, Chand, Meera A, additional, Brown, Colin S, additional, Ramsay, Mary, additional, Lopez-Bernal, Jamie, additional, Hopkins, Susan, additional, Andrews, N, additional, Atti, A, additional, Aziz, H, additional, Brooks, T, additional, Brown, CS, additional, Camero, D, additional, Carr, C, additional, Chand, MA, additional, Charlett, A, additional, Crawford, H, additional, Cole, M, additional, Conneely, J, additional, D'Arcangelo, S, additional, Ellis, J, additional, Evans, S, additional, Foulkes, S, additional, Gillson, N, additional, Gopal, R, additional, Hall, L, additional, Hall, VJ, additional, Harrington, P, additional, Hopkins, S, additional, Hewson, J, additional, Hoschler, K, additional, Ironmonger, D, additional, Islam, J, additional, Kall, M, additional, Karagiannis, I, additional, Kay, O, additional, Khawam, J, additional, King, E, additional, Kirwan, P, additional, Kyffin, R, additional, Lackenby, A, additional, Lattimore, M, additional, Linley, E, additional, Lopez-Bernal, J, additional, Mabey, L, additional, McGregor, R, additional, Miah, S, additional, Monk, EJM, additional, Munro, K, additional, Naheed, Z, additional, Nissr, A, additional, O'Connell, AM, additional, Oguti, B, additional, Okafor, H, additional, Organ, S, additional, Osbourne, J, additional, Otter, A, additional, Patel, M, additional, Platt, S, additional, Pople, D, additional, Potts, K, additional, Ramsay, M, additional, Robotham, J, additional, Rokadiya, S, additional, Rowe, C, additional, Saei, A, additional, Sebbage, G, additional, Semper, A, additional, Shrotri, M, additional, Simmons, R, additional, Soriano, A, additional, Staves, P, additional, Taylor, S, additional, Taylor, A, additional, Tengbe, A, additional, Tonge, S, additional, Vusirikala, A, additional, Wallace, S, additional, Wellington, E, additional, Zambon, M, additional, Corrigan, D, additional, Sartaj, M, additional, Cromey, L, additional, Campbell, S, additional, Braithwaite, K, additional, Price, L, additional, Haahr, L, additional, Stewart, S, additional, Lacey, ED, additional, Partridge, L, additional, Stevens, G, additional, Ellis, Y, additional, Hodgson, H, additional, Norman, C, additional, Larru, B, additional, Mcwilliam, S, additional, Roynon, A, additional, Northfield, J, additional, Winchester, S, additional, Cieciwa, P, additional, Pai, A, additional, Bakker, P, additional, Loughrey, C, additional, Watt, A, additional, Adair, F, additional, Hawkins, A, additional, Grant, A, additional, Temple-Purcell, R, additional, Howard, J, additional, Slawson, N, additional, Subudhi, C, additional, Davies, S, additional, Bexley, A, additional, Penn, R, additional, Wong, N, additional, Boyd, G, additional, Rajgopal, A, additional, Arenas-Pinto, A, additional, Matthews, R, additional, Whileman, A, additional, Laugharne, R, additional, Ledger, J, additional, Barnes,, T, additional, Jones, C, additional, Osuji, N, additional, Chitalia, N, additional, Bailey, T, additional, Akhtar, S, additional, Harrison, G, additional, Horne, S, additional, Walker, N, additional, Agwuh, K, additional, Maxwell, V, additional, Graves, J, additional, Williams, S, additional, O'Kelly, A, additional, Ridley, P, additional, Cowley, A, additional, Johnstone, H, additional, Swift, P, additional, Democratis, J, additional, Meda, M, additional, Brake, S, additional, Gunn, J, additional, Selassi, A, additional, Hams, S, additional, Irvine, V, additional, Chandrasekaran, B, additional, Forsyth, C, additional, Radmore, J, additional, Thomas, C, additional, Brown, K, additional, Roberts, S, additional, Burns, P, additional, Gajee, K, additional, Lewis, T, additional, Byrne, TM, additional, Sanderson, F, additional, Knight, S, additional, Macnaughton, E, additional, Burton, BJL, additional, Smith, H, additional, Chaudhuri, R, additional, Aeron-Thomas, J, additional, Hollinshead, K, additional, Shorten, RJ, additional, Swan, A, additional, Favager, C, additional, Murira, J, additional, Baillon, S, additional, Hamer, S, additional, Shah, A, additional, Russell, J, additional, Brennan, D, additional, Dave, A, additional, Chawla, A, additional, Westwell, F, additional, Adeboyeku, D, additional, Papineni, P, additional, Pegg, C, additional, Williams, M, additional, Ahmad, S, additional, Horsley, A, additional, Gabriel, C, additional, Pagget, K, additional, Maloney, G, additional, Ashcroft, J, additional, Del Rosario, I, additional, Crosby-Nwaobi, R, additional, Flanagan, D, additional, Dhasmana, D, additional, Fowler, S, additional, Cameron, E, additional, Prentice, L, additional, Sinclair, C, additional, Bateman, V, additional, McLelland-Brooks, K, additional, Ho, A, additional, Murphy, M, additional, Cochrane, A, additional, Gibson, A, additional, Black, K, additional, Tempeton, K, additional, Donaldson, S, additional, Coke, L, additional, Elumogo, N, additional, Elliott, J, additional, Padgett, D, additional, Cross, A, additional, Mirfenderesky, M, additional, Joyce, S, additional, Sinanovic, I, additional, Howard, M, additional, Cowling, P, additional, Brazil, M, additional, Hanna, E, additional, Abdelrazik, A, additional, Brand, S, additional, Sheridan, EA, additional, Wadams, B, additional, Lloyd, A, additional, Mouland, J, additional, Giles, J, additional, Pottinger, G, additional, Coles, H, additional, Joseph, M, additional, Lee, M, additional, Orr, S, additional, Chenoweth, H, additional, Browne, D, additional, Auckland, C, additional, Lear, R, additional, Mahungu, T, additional, Rodger, A, additional, Warren, S, additional, Brooking, D, additional, Pai, S, additional, Druyeh, R, additional, Smith, E, additional, Stone, S, additional, Meisner, S, additional, Delgado, D, additional, Underhill, E, additional, Keen, L, additional, Aga, M, additional, Domingos, P, additional, Gormley, S, additional, Kerrison, C, additional, Birch, S, additional, DeSilva, T, additional, Allsop, L, additional, Ambalkar, S, additional, Beekes, M, additional, Jose, S, additional, Tomlinson, J, additional, Painter, Sharen, additional, Price, C, additional, Pepperell, J, additional, James, K, additional, Trinick, T, additional, Moore, L, additional, Day, J, additional, Boulos, A, additional, Knox, I, additional, Defever, E, additional, McCracken, D, additional, Gray, K, additional, Houston, A, additional, Planche, T, additional, Pritchard Jones, R, additional, Wycherley, Diane, additional, Bennett, S, additional, Marrs, J, additional, Nimako, K, additional, Stewart, B, additional, Bain, SC, additional, Kalakonda, N, additional, Khanduri, S, additional, Ashby, A, additional, Holden, M, additional, Mahabir, N, additional, Harwood, J, additional, Payne, B, additional, Court, K, additional, White, N, additional, Longfellow, R, additional, Hughes, LE, additional, Green, ME, additional, Halkes, M, additional, Mercer, P, additional, Roebuck, A, additional, Wilson-Davies, E, additional, Gallego, L, additional, Lazarus, R, additional, Aldridge, N, additional, Berry, L, additional, Game, F, additional, Reynolds, T, additional, Holmes, C, additional, Wiselka, M, additional, Higham, A, additional, Booth, M, additional, Duff, C, additional, Alderton, J, additional, Hilton, D, additional, Powell, J, additional, Jackson, A, additional, Plant, AJ, additional, Ahmed, N, additional, Chin, T, additional, Qazzafi, MZ, additional, Moody, AM, additional, Tilley, RE, additional, Donaghy, T, additional, O'Kane, M, additional, Shipman, K, additional, Sierra, R, additional, Parmar, C, additional, Mills, G, additional, Harvey, D, additional, Huang, YWJ, additional, Birch, J, additional, Robinson, L, additional, Board, S, additional, Broadley, A, additional, Laven, C, additional, Todd, N, additional, Eyre, DW, additional, Jeffery, K, additional, Dunachie, S, additional, Duncan, C, additional, Klenerman, P, additional, Turtle, L, additional, Baxendale, H, additional, and Heeney, JL, additional

Published
2021
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10. SARS-CoV-2 infection rates of antibody-positive compared with antibody-negative health-care workers in England: a large, multicentre, prospective cohort study (SIREN)

Author

Hall, Victoria Jane, primary, Foulkes, Sarah, additional, Charlett, Andre, additional, Atti, Ana, additional, Monk, Edward J M, additional, Simmons, Ruth, additional, Wellington, Edgar, additional, Cole, Michelle J, additional, Saei, Ayoub, additional, Oguti, Blanche, additional, Munro, Katie, additional, Wallace, Sarah, additional, Kirwan, Peter D, additional, Shrotri, Madhumita, additional, Vusirikala, Amoolya, additional, Rokadiya, Sakib, additional, Kall, Meaghan, additional, Zambon, Maria, additional, Ramsay, Mary, additional, Brooks, Tim, additional, Brown, Colin S, additional, Chand, Meera A, additional, Hopkins, Susan, additional, Andrews, N, additional, Atti, A, additional, Aziz, H, additional, Brooks, T, additional, Brown, CS, additional, Camero, D, additional, Carr, C, additional, Chand, MA, additional, Charlett, A, additional, Crawford, H, additional, Cole, M, additional, Conneely, J, additional, D'Arcangelo, S, additional, Ellis, J, additional, Evans, S, additional, Foulkes, S, additional, Gillson, N, additional, Gopal, R, additional, Hall, L, additional, Hall, VJ, additional, Harrington, P, additional, Hopkins, S, additional, Hewson, J, additional, Hoschler, K, additional, Ironmonger, D, additional, Islam, J, additional, Kall, M, additional, Karagiannis, I, additional, Kay, O, additional, Khawam, J, additional, King, E, additional, Kirwan, P, additional, Kyffin, R, additional, Lackenby, A, additional, Lattimore, M, additional, Linley, E, additional, Lopez-Bernal, J, additional, Mabey, L, additional, McGregor, R, additional, Miah, S, additional, Monk, EJM, additional, Munro, K, additional, Naheed, Z, additional, Nissr, A, additional, O'Connell, AM, additional, Oguti, B, additional, Okafor, H, additional, Organ, S, additional, Osbourne, J, additional, Otter, A, additional, Patel, M, additional, Platt, S, additional, Pople, D, additional, Potts, K, additional, Ramsay, M, additional, Robotham, J, additional, Rokadiya, S, additional, Rowe, C, additional, Saei, A, additional, Sebbage, G, additional, Semper, A, additional, Shrotri, M, additional, Simmons, R, additional, Soriano, A, additional, Staves, P, additional, Taylor, S, additional, Taylor, A, additional, Tengbe, A, additional, Tonge, S, additional, Vusirikala, A, additional, Wallace, S, additional, Wellington, E, additional, Zambon, M, additional, Corrigan, D, additional, Sartaj, M, additional, Cromey, L, additional, Campbell, S, additional, Braithwaite, K, additional, Price, L, additional, Haahr, L, additional, Stewart, S, additional, Lacey, ED, additional, Partridge, L, additional, Stevens, G, additional, Ellis, Y, additional, Hodgson, H, additional, Norman, C, additional, Larru, B, additional, Mcwilliam, S, additional, Winchester, S, additional, Cieciwa, P, additional, Pai, A, additional, Loughrey, C, additional, Watt, A, additional, Adair, F, additional, Hawkins, A, additional, Grant, A, additional, Temple-Purcell, R, additional, Howard, J, additional, Slawson, N, additional, Subudhi, C, additional, Davies, S, additional, Bexley, A, additional, Penn, R, additional, Wong, N, additional, Boyd, G, additional, Rajgopal, A, additional, Arenas-Pinto, A, additional, Matthews, R, additional, Whileman, A, additional, Laugharne, R, additional, Ledger, J, additional, Barnes, T, additional, Jones, C, additional, Botes, D, additional, Chitalia, N, additional, Akhtar, S, additional, Harrison, G, additional, Horne, S, additional, Walker, N, additional, Agwuh, K, additional, Maxwell, V, additional, Graves, J, additional, Williams, S, additional, O'Kelly, A, additional, Ridley, P, additional, Cowley, A, additional, Johnstone, H, additional, Swift, P, additional, Democratis, J, additional, Meda, M, additional, Callens, C, additional, Beazer, S, additional, Hams, S, additional, Irvine, V, additional, Chandrasekaran, B, additional, Forsyth, C, additional, Radmore, J, additional, Thomas, C, additional, Brown, K, additional, Roberts, S, additional, Burns, P, additional, Gajee, K, additional, Byrne, TM, additional, Sanderson, F, additional, Knight, S, additional, Macnaughton, E, additional, Burton, BJL, additional, Smith, H, additional, Chaudhuri, R, additional, Hollinshead, K, additional, Shorten, RJ, additional, Swan, A, additional, Favager, C, additional, Murira, J, additional, Baillon, S, additional, Hamer, S, additional, Gantert, K, additional, Russell, J, additional, Brennan, D, additional, Dave, A, additional, Chawla, A, additional, Westell, F, additional, Adeboyeku, D, additional, Papineni, P, additional, Pegg, C, additional, Williams, M, additional, Ahmad, S, additional, Ingram, S, additional, Gabriel, C, additional, Pagget, K, additional, Maloney, G, additional, Ashcroft, J, additional, Del Rosario, I, additional, Crosby-Nwaobi, R, additional, Reeks, C, additional, Fowler, S, additional, Prentice, L, additional, Spears, M, additional, McKerron, G, additional, McLelland-Brooks, K, additional, Anderson, J, additional, Donaldson, S, additional, Templeton, K, additional, Coke, L, additional, Elumogo, N, additional, Elliott, J, additional, Padgett, D, additional, Mirfenderesky, M, additional, Cross, A, additional, Price, J, additional, Joyce, S, additional, Sinanovic, I, additional, Howard, M, additional, Lewis, T, additional, Cowling, P, additional, Potoczna, D, additional, Brand, S, additional, Sheridan, L, additional, Wadams, B, additional, Lloyd, A, additional, Mouland, J, additional, Giles, J, additional, Pottinger, G, additional, Coles, H, additional, Joseph, M, additional, Lee, M, additional, Orr, S, additional, Chenoweth, H, additional, Auckland, C, additional, Lear, R, additional, Mahungu, T, additional, Rodger, A, additional, Penny-Thomas, K, additional, Pai, S, additional, Zamikula, J, additional, Smith, E, additional, Stone, S, additional, Boldock, E, additional, Howcroft, D, additional, Thompson, C, additional, Aga, M, additional, Domingos, P, additional, Gormley, S, additional, Kerrison, C, additional, Marsh, L, additional, Tazzyman, S, additional, Allsop, L, additional, Ambalkar, S, additional, Beekes, M, additional, Jose, S, additional, Tomlinson, J, additional, Jones, A, additional, Price, C, additional, Pepperell, J, additional, Schultz, M, additional, Day, J, additional, Boulos, A, additional, Defever, E, additional, McCracken, D, additional, Gray, K, additional, Houston, A, additional, Planche, T, additional, Pritchard Jones, R, additional, Wycherley, Diane, additional, Bennett, S, additional, Marrs, J, additional, Nimako, K, additional, Stewart, B, additional, Kalakonda, N, additional, Khanduri, S, additional, Ashby, A, additional, Holden, M, additional, Mahabir, N, additional, Harwood, J, additional, Payne, B, additional, Court, K, additional, Staines, N, additional, Longfellow, R, additional, Green, ME, additional, Hughes, LE, additional, Halkes, M, additional, Mercer, P, additional, Roebuck, A, additional, Wilson-Davies, E, additional, Gallego, L, additional, Lazarus, R, additional, Aldridge, N, additional, Berry, L, additional, Game, F, additional, Reynolds, T, additional, Holmes, C, additional, Wiselka, M, additional, Higham, A, additional, Booth, M, additional, Duff, C, additional, Alderton, J, additional, Jory, H, additional, Virgilio, E, additional, Chin, T, additional, Qazzafi, MZ, additional, Moody, AM, additional, Tilley, R, additional, Donaghy, T, additional, Shipman, K, additional, Sierra, R, additional, Jones, N, additional, Mills, G, additional, Harvey, D, additional, Huang, YWJ, additional, Birch, J, additional, Robinson, L, additional, Board, S, additional, Broadley, A, additional, Laven, C, additional, Todd, N, additional, Eyre, DW, additional, Jeffery, K, additional, Dunachie, S, additional, Duncan, C, additional, Klenerman, P, additional, Turtle, L, additional, De Silva, T, additional, Baxendale, H, additional, and Heeney, JL, additional

Published
2021
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15. Impact of Safety-Related Dose Reductions or Discontinuations on Sustained Virologic Response in HCV-Infected Patients: Results from the GUARD-C Cohort

Author

GUARD C, Study Group, Hassanein, T, Bakalos, G, Ahlers, S, Shiffman, Ml, Tallarico, L, Reddy, Kr, Orlandini, A, Ferenci, P, Derbala, M, Coppola, C, Foster, Gr, Basho, J, Shabanaj, G, Harxhi, A, Debzi, N, Afredj, N, Guessab, N, Mahindad, N, Mahiou, H, Aissaoui, M, Al Qameesh, J, Al Ghandoor, Z, Assene, C, Bastens, B, Brixko, C, Cool, M, De Galocsy, C, Delwaide, J, George, C, Laukens, P, Lefebvre, V, Mulkay, Jp, Nevens, F, Servais, B, Van Vlierberghe, H, Horsmans, Y, Henrion, J, Sprengers, D, Michielsen, P, Bourgeois, S, Lasser, L, Langlet, P, Robaeys, G, Martinet, Jp, Warzee, P, Hoste, P, Reynaert, H, Juriens, I, Decaestecker, J, Van Der Meersch, F, Janssens, F, Ahmetagic, S, Verhaz, A, Bevanda, M, Calkic, L, Ibrahimpasic, N, Mesihovic, R, Mello, Ce, Ruiz, Fj, Martins Junior, E, Ferraz, Ml, Silva, G, Mendes, C, Lyra, A, Silva, Mh, Gomide, G, Fernandes, Jc, Pereira, P, Correa, Mc, Teixeira, R, Yousry, A, Hanno, A, Gabr, M, Omar, A, Esmat, G, Karatapanis, S, Nikolopoulou, V, Giannoulis, G, Manolakopoulos, S, Elefsiniotis, I, Drakoulis, C, Dimitroulopoulos, D, Kanatakis, S, Ketikoglou, I, Mimidis, K, Evgenidis, N, Akriviades, E, Vafiadi Zoubouli, I, Tsianos, E, Mela, M, Orfanou, E, Mousoulis, G, Karagiannis, I, Manesis, E, Varga, M, Nemesánszky, E, Fried, K, Schuller, J, Szalay, F, Lengyel, G, Tornai, I, Banyai, T, Lesch, M, Nagy, I, Gervain, J, Tusnadi, A, Schneider, F, Szentgyörgyi, L, Hunyady, B, Vincze, A, Tolvaj, G, Varkonyi, I, Makkai, E, Enyedi, J, Racz, I, Hausinger, P, Váczi, Z, Patai, Á, Ozsvár, Z, Lakner, L, Ribiczey, P, Bhalla, A, Somani, S, Luaia, R, Rao, P, Philip, M, Lawate, P, Nagral, A, Sood, A, Parikh, S, Merat, S, Nassiri Toosi, M, Alavian, Sm, Zali, Mr, Daryani, Ne, Drenaggi, D, Attili, Af, Bandiera, F, Bassi, P, Bellati, G, Bellantani, S, Brunetto, MAURIZIA ROSSANA, Bruno, S, Castelli, F, Castellacci, R, Cattelan, Am, Colombo, M, Craxi, A, D'Angelo, S, Colombo, S, Demelia, L, Di Perri, G, Di Giacomo, A, Ferrari, C, Francisci, D, Casinelli, K, Ganga, R, Costa, C, Mangia, A, Russo, Fp, Matarazzo, F, Mazzella, G, Mazzeo, M, Memoli, M, Montalbano, M, Montalto, G, Pieri, A, Passariello, N, Picciotto, A, Pietrangelo, A, Pirisi, M, Quirino, T, Raimondo, G, Rapaccini, Gl, Rizzardini, G, Rizzetto, M, Russello, M, Sabusco, G, Santantonio, T, Soardo, G, Amedea, A, Verucchi, G, Vinelli, F, Zignego, Al, Zuin, M, Ascione, A, Vinci, M, Pigozzi, Mg, Tundo, P, Saracco, Gm, Amoroso, P, Andreoni, M, Colletta, C, Erne, E, Megna, As, Biglino, A, Chiriaco, P, Foti, G, Spinzi, G, D'Amico, E, Paik, Sw, Ahn, Sh, Lee, Yn, Kim, Y, Yang, J, Han, Sy, Varghese, R, Al Gharabally, A, Askar, H, Sharara, A, Yaghi, C, Rached, Aa, Houmani, Z, Zaarour, F, Dohaibi, A, Ivanovski, L, Joksimovic, N, Abbas, Z, Memon, S, Mohsin, A, Masood, S, Hashmi, Z, Halota, W, Deron, Z, Mazur, W, Flisiak, R, Lipczynski, A, Musialik, J, Piekarska, A, Augustyniak, K, Baka Cwierz, B, Simon, K, Gietka, A, Berak, H, Sieklucki, J, Radowska, D, Szlauer, B, Piekos, T, Olszok, I, Jablkowski, M, Orszulak, G, Warakomska, I, Aleixo, Mj, Valente, C, Macedo, G, Sarmento Castro, R, Roxo, F, Faria, T, Mansinho, K, Velez, J, Ramos, Jp, Guerreiro, H, Alberto, S, Monteverde, C, Serejo, F, Peixe, P, Malhado, J, Curescu, M, Streinu Cercel, A, Caruntu, F, Livia, H, Preotescu, L, Arama, V, Ancuta, I, Gheorghe, L, Stanciu, C, Trifan, A, Acalovschi, M, Andreica, V, Pascu, O, Lencu, M, Sporea, I, Olteanu, D, Ionita Radu, F, Fierbinteanu Braticevici, C, Motoc, A, Silaghi, R, Musat, M, Coman, F, Stan, M, Cijevschi, C, Miftode, E, Delic, D, Jesic, R, Nozic, D, Svorcan, P, Fabri, M, Konstantinovic, L, Pelemis, M, Jankovic, G, Todorovic, Z, Nagorni, A, Kupcova, V, Skladany, L, Szantova, M, Krkoska, D, Jarcuska, P, Schreter, I, Oltman, M, Bocakova, J, Bunganic, I, Holoman, J, Giguere, A, Abdou, A. M., Basic (bio-) Medical Sciences, Gastroenterology, Laboratory of Molecullar and Cellular Therapy, Liver Cell Biology, Michielsen, Peter, GUARD-C Study Group, Graham R. Foster, Carmine Coppola, Moutaz Derbala, Peter Ferenci, Alessandra Orlandini, K. Rajender Reddy, Ludovico Tallarico, Mitchell L. Shiffman, Silke Ahler, Georgios Bakalo, Tarek Hassanein, GUARD-C Study Group: [.., Davide Drenaggi, Adolfo Francesco Attili, Franco Bandiera, Paolo Bassi, Giorgio Bellati, Stefano Bellantani, Maurizia Brunetto, Savino Bruno, Francesco Castelli, Roberto Castellacci, Anna Maria Cattelan, Massimo Colombo, Antonio Craxi, Salvatore D'angelo, Silvia Colombo, Luigi Demelia, Giovanni Di Perri, Antonio Di Giacomo, Carlo Ferrari, Daniela Francisci, Katia Casinelli, Roberto Ganga, Chiara Costa, Alessandra Mangia, Francesco Paolo Russo, Filippo Matarazzo, Giuseppe Mazzella, Maurizio Mazzeo, Massimo Memoli, Marzia Montalbano, Giuseppe Montalto, Alessandro Pieri, Nicola Passariello, Antonio Picciotto, Antonello Pietrangelo, Mario Pirisi, Tiziana Quirino, Giovanni Raimondo, Gian Ludovico Rapaccini, Giuliano Rizzardini, Mario Rizzetto, Maurizio Russello, Giuseppe Sabusco, Teresa Santantonio, Giorgio Soardo, Alessandri Amedea, Gabriella Verucchi, Francesco Vinelli, Anna Linda Zignego, Massimo Zuin, Antonio Ascione, Maria Vinci, Maria Graziella Pigozzi, Paolo Tundo, Giorgio Maria Saracco, Pietro Amoroso, Massimo Andreoni, Cosimo Colletta, Elke Erne, Angelo Salomone Megna, Alberto Biglino, Piergiorgio Chiriaco, Giuseppe Foti, Giancarlo Spinzi, Emilio D'amico, …], Foster G.R., Coppola C., Derbala M., Ferenci P., Orlandini A., Reddy K.R., Tallarico L., Shiffman M.L., Ahlers S., Bakalos G., Hassanein T., Basho J., Shabanaj G., Harxhi A., Debzi N., Afredj N., Guessab N., Mahindad N., Mahiou H., Aissaoui M., Al Qameesh J., Al Ghandoor Z., Assene C., Bastens B., Brixko C., Cool M., De Galocsy C., Delwaide J., George C., Laukens P., Lefebvre V., Mulkay J.-P., Nevens F., Servais B., Van Vlierberghe H., Horsmans Y., Henrion J., Sprengers D., Michielsen P., Bourgeois S., Lasser L., Langlet P., Robaeys G., Martinet J.-P., Warzee P., Hoste P., Reynaert H., Juriens I., Decaestecker J., Van Der Meersch F., Janssens F., Ahmetagic S., Verhaz A., Bevanda M., Calkic L., Ibrahimpasic N., Mesihovic R., Mello C.E., Ruiz F.J., Junior E.M., Ferraz M.L., Silva G., Mendes C., Lyra A., Silva M.H., Gomide G., Fernandes J.C., Pereira P., Correa M.C., Teixeira R., Yousry A., Hanno A., Gabr M., Omar A., Esmat G., Karatapanis S., Nikolopoulou V., Giannoulis G., Manolakopoulos S., Elefsiniotis I., Drakoulis C., Dimitroulopoulos D., Kanatakis S., Ketikoglou I., Mimidis K., Evgenidis N., Akriviades E., Vafiadi-Zoubouli I., Tsianos E., Mela M., Orfanou E., Mousoulis G., Karagiannis I., Manesis E., Varga M., Nemesanszky E., Fried K., Schuller J., Szalay F., Lengyel G., Tornai I., Banyai T., Lesch M., Nagy I., Gervain J., Tusnadi A., Schneider F., Szentgyorgyi L., Hunyady B., Vincze A., Tolvaj G., Varkonyi I., Makkai E., Enyedi J., Racz I., Hausinger P., Vaczi Z., Patai A., Ozsvar Z., Lakner L., Ribiczey P., Bhalla A., Somani S., Luaia R., Rao P., Philip M., Lawate P., Nagral A., Sood A., Parikh S., Merat S., Nassiri-Toosi M., Alavian S.-M., Zali M.R., Daryani N.E., Drenaggi D., Attili A.F., Bandiera F., Bassi P., Bellati G., Bellantani S., Brunetto M., Bruno S., Castelli F., Castellacci R., Cattelan A.M., Colombo M., Craxi A., D'angelo S., Colombo S., Demelia L., Di Perri G., Di Giacomo A., Ferrari C., Francisci D., Casinelli K., Ganga R., Costa C., Mangia A., Russo F.P., Matarazzo F., Mazzella G., Mazzeo M., Memoli M., Montalbano M., Montalto G., Pieri A., Passariello N., Picciotto A., Pietrangelo A., Pirisi M., Quirino T., Raimondo G., Rapaccini G.L., Rizzardini G., Rizzetto M., Russello M., Sabusco G., Santantonio T., Soardo G., Amedea A., Verucchi G., Vinelli F., Zignego A.L., Zuin M., Ascione A., Vinci M., Pigozzi M.G., Tundo P., Saracco G.M., Amoroso P., Andreoni M., Colletta C., Erne E., Megna A.S., Biglino A., Chiriaco P., Foti G., Spinzi G., D'amico E., Paik S.W., Ahn S.-H., Lee Y.N., Kim Y., Yang J., Han S.Y., Varghese R., Al Gharabally A., Askar H., Sharara A., Yaghi C., Abou Rached A., Houmani Z., Zaarour F., Dohaibi A., Ivanovski L., Joksimovic N., Abbas Z., Memon S., Mohsin A., Masood S., Hashmi Z., Halota W., Deron Z., Mazur W., Flisiak R., Lipczynski A., Musialik J., Piekarska A., Augustyniak K., Baka-Cwierz B., Simon K., Gietka A., Berak H., Sieklucki J., Radowska D., Szlauer B., Piekos T., Olszok I., Jablkowski M., Orszulak G., Warakomska I., Aleixo M.J., Valente C., Macedo G., Sarmento-Castro R., Roxo F., Faria T., Mansinho K., Velez J., Ramos J.P., Guerreiro H., Alberto S., Monteverde C., Serejo F., Peixe P., Malhado J., Curescu M., Streinu-Cercel A., Caruntu F., Livia H., Preotescu L., Arama V., Ancuta I., Gheorghe L., Stanciu C., Trifan A., Acalovschi M., Andreica V., Pascu O., Lencu M., Sporea I., Olteanu D., Ionita-Radu F., Fierbinteanu-Braticevici C., Motoc A., Silaghi R., Musat M., Coman F., Stan M., Cijevschi C., Miftode E., Delic D., Jesic R., Nozic D., Svorcan P., Fabri M., Konstantinovic L., Pelemis M., Jankovic G., Todorovic Z., Nagorni A., Kupcova V., Skladany L., Szantova M., Krkoska D., Jarcuska P., Schreter I., Oltman M., Bocakova J., Bunganic I., Holoman J., Giguere A., Abdou A.M.S., UCL - SSS/IREC-Institut de recherche expérimentale et clinique, UCL - SSS/IREC/GAEN-Pôle d'Hépato-gastro-entérologie, and UCL - (SLuc) Service de gastro-entérologie

Subjects
Genetics and Molecular Biology (all), Male, Chronic Hepatitis, Hepacivirus, Ribavirin/adverse effects, Asthenia/chemically induced, Polyethylene Glycol, Biochemistry, Polyethylene Glycols, Body Mass Index, Chronic Liver Disease, 0302 clinical medicine, Neutropenia/chemically induced, Interferon-alpha/adverse effects, Medicine, Chronic, lcsh:Science, Liver Diseases, virus diseases, Antiviral Agents/adverse effects, Cohort, Science & Technology - Other Topics, 030211 gastroenterology & hepatology, Drug Therapy, Combination, Cohort study, Human, medicine.medical_specialty, Alpha interferon, Gastroenterology and Hepatology, Antiviral Agents, Microbiology, Dose-Response Relationship, 03 medical and health sciences, Pharmacotherapy, Hepatitis C, Chronic/drug therapy, Dose Prediction Methods, Drug Therapy, Anemia/chemically induced, Humans, Hemoglobin, Aged, Medicine and health sciences, Biochemistry, Genetics and Molecular Biology (all), Hepaciviru, Science & Technology, Dose-Response Relationship, Drug, Flaviviruses, lcsh:R, Organisms, Biology and Life Sciences, Proteins, medicine.disease, digestive system diseases, chemistry, Agricultural and Biological Sciences (all), Withholding Treatment, Asthenia, Immunology, Proportional Hazards Model, lcsh:Q, Human medicine, RNA viruses, Physiology, lcsh:Medicine, Peginterferon-alfa, Polyethylene Glycols/adverse effects, Adult, Anemia, Cohort Studies, Female, Hepatitis C, Chronic, Host-Pathogen Interactions, Interferon-alpha, Middle Aged, Neutropenia, Outcome Assessment (Health Care), Proportional Hazards Models, RNA, Viral, Recombinant Proteins, Ribavirin, Medicine (all), chemistry.chemical_compound, Outcome Assessment, Health Care, Medicine and Health Sciences, 030212 general & internal medicine, Viral, Pathology and laboratory medicine, Multidisciplinary, biology, Hepatitis C virus, Pharmaceutics, Hepatitis C, Hematology, Recombinant Protein, Outcome Assessment (Health Care)/methods, Medical microbiology, Host-Pathogen Interaction, Multidisciplinary Sciences, Physiological Parameters, Research Design, Combination, Viruses, Drug, Pathogens, Host-Pathogen Interactions/drug effects, Research Article, Clinical Research Design, Research and Analysis Methods, Internal medicine, Recombinant Proteins/adverse effects, RNA, Viral/blood, Antiviral Agent, business.industry, Body Weight, Hepacivirus/drug effects, Viral pathogens, biology.organism_classification, Hepatitis viruses, Microbial pathogens, RNA, Adverse Events, Cohort Studie, business
Abstract

Background: Despite the introduction of direct-acting antiviral agents for chronic hepatitis C virus (HCV) infection, peginterferon alfa/ribavirin remains relevant in many resource-constrained settings. The non-randomized GUARD-C cohort investigated baseline predictors of safety-related dose reductions or discontinuations (sr-RD) and their impact on sustained virologic response (SVR) in patients receiving peginterferon alfa/ribavirin in routine practice. Methods: A total of 3181 HCV-mono-infected treatment-naive patients were assigned to 24 or 48 weeks of peginterferon alfa/ribavirin by their physician. Patients were categorized by time-to-first sr-RD (Week 4/12). Detailed analyses of the impact of sr-RD on SVR24 (HCV RNA

Published
2015

16. Prikaccidenten in de arbeidssituatie

Author

Ruijs WLM, Wijk PThL van, Heimeriks CT, Boland GJ, Karagiannis I, Geraedts J, and LCI

Subjects
VEILIGHEID
Abstract

Deze notitie is opgesteld met medewerking van Nationaal Hepatitis Centrum, Jeroen Bosch Ziekenhuis, KeurCompany, Academisch Medisch Centrum, GGD Rotterdam-Rijnmond en diverse brancheorganisaties

Published
2012

17. A waterborne Campylobacter jejuni outbreak on a Greek island

Author

Karagiannis, I. Sideroglou, T. Gkolfinopoulou, K. Tsouri, A. and Lampousaki, D. Velonakis, E. N. Scoulica, E. V. Mellou, K. Panagiotopoulos, T. Bonovas, S.

Abstract

A case-control and a case-crossover study were performed to investigate a Campylobacter jejuni outbreak in Crete in 2009. Most cases originated from rural areas, served by a different water-supply system from that of the adjacent town. Thirty-seven cases and 79 controls were interviewed; cases were interviewed for two different time periods for the case-crossover study. Stool cultures, PFGE and MLST subtyping were run in human samples. Univariately, consumption of tap water was associated with C. jejuni infection. Stratified analysis revealed that water-supply system was an effect modifier of this association. In the multivariable analysis, the rural areas’ water supplier and drinking tap water were risk factors. No risk factors were revealed in the case-crossover study. No Campylobacter were isolated in the tested water samples. There is strong epidemiological evidence that tap water was the vehicle of the outbreak.

Published
2010

18. Effect of compression ring elastodynamics behaviour upon blowby and power loss

Author

Baker, CE, Rahmani, R, Karagiannis, I, Theodossiades, S, Rahnejat, Homer, Frendt, A, Baker, CE, Rahmani, R, Karagiannis, I, Theodossiades, S, Rahnejat, Homer, and Frendt, A

Abstract

The automotive industry is subject to increasing pressure to reduce the CO emissions and improve fuel efficiency in internal combustion engines. Improvements may be achieved in a number of ways. The parasitic losses throughout the engine cycle emanate from friction in all engine contact conjunctions in addition to pumping losses. In particular one main contributory conjunction is the piston ring pack assembly. At low engine speeds, the contribution of friction to the total losses within the engine is increased significantly compared with the thermodynamic losses. Additionally, the sealing capability of the ring is crucial in determining the power output of the engine with any loss of sealing contributing to power loss, as well as blowby. Most reported studies on compression ring-cylinder conjunction do not take into account complex ring in-plane and out-of-plane elastodynamics. Hitherto, there has not been a numerical methodology which integrates tribology of an elastic compression ring, subject to modal behaviour in a coupled solution. This paper discusses the inclusion of transient ring elastodynamics of the top compression ring, interacting with blowby effects within the ring pack. The ring dynamics methodology is briefly highlighted for both in-plane and out-of-plane motions. In addition, a one-dimensional gas flow model that captures blowby behaviour is included. A case study is presented, using measured engine data. Gas flow and frictional losses at various engine speeds are predicted. The effect of gas blowby on the ring's tribological response can be ascertained, as well as the ring's dynamic motion within its retaining groove. Copyright © 2014 SAE International.

Published
2014

20. The Effect of Vehicle Cruising Speed on the Dynamics of Automotive Hypoid Gears

Author

Karagiannis, I, Theodossiades, S, Rahnejat, Homer, Karagiannis, I, Theodossiades, S, and Rahnejat, Homer

Abstract

The dynamics of automotive differentials have been studied extensively to improve their efficiency and additionally, in recent years, generated noise and vibration. Various mathematical models have been proposed to describe the contact/impact of gear teeth pairs. However, the influence of vehicular cruising speed on the resisting torque has not been considered in sufficient detail. This can lead to unrealistic predictions with regards to loss of contact of teeth pair, a phenomenon which leads to NVH issues. The current work presents a torsional model of a hypoid gear pair. The resisting torque is a function of the traction force and aerodynamic drag, whilst the vehicle is cruising at nominally constant speed. The pinion input torque is derived through assumed instantaneous equilibrium conditions. In this approach, realistic excitation capturing the vehicle's driving conditions is imposed on the dynamics of the hypoid gear pair. The dependence of the gear pair meshing stiffness on the torque amplitude is also considered using Tooth Contact Analysis (TCA). As a result the natural frequency of the system is subject to condition-based variations. The dynamic response of the system is presented at various cruising speeds. Frequency response spectra are derived to illustrate the limiting speed when gear flank separation occurs. The novelty of this model is related to the accurate prediction of gear teeth impacts, leading to the appearance of the axle whine phenomenon. The validation of the numerical findings with published experimental data is part of the planned future work.

Published
2012

21. On the dynamics of lubricated hypoid gears

Author

Karagiannis, I, Theodossiades, S, Rahnejat, Homer, Karagiannis, I, Theodossiades, S, and Rahnejat, Homer

Abstract

The torsional dynamics of a vehicle differential hypoid gear pair is investigated. The model comprises applied torque, representing transmitted engine power, including engine order vibration. A number of gear teeth pairs transmit the applied torque through their lubricated conjunctions. Tooth contact analysis (TCA) is used to obtain the appropriate geometrical, kinematic and meshing parameters. These enable the evaluation of contact loads, film thickness and friction for conjugate teeth pairs, which are subject to mixed thermo-elastohydrodynamic regime of lubrication. It is shown that the lubricant undergoes non-Newtonian shear in line with the Eyring regime of traction. The inclusion of combined thermal non-Newtonian shear and boundary interactions has not hitherto been reported for the tribo-dynamics of hypoid gear pairs. When rate of change of gear teeth contact radii is included in the analysis more complex system dynamics (loss of teeth contact) result, particularly at higher speeds. The stated features constitute the main contributions of the current work, which have not hitherto been reported in literature. It is also shown that teeth contact separation ensues when resonant conditions are noted. This is regarded as the main root cause of a noise and vibration phenomenon, known as axle whine.

Published
2011

22. Occupational blood exposure accidents in the Netherlands.

Author

Wijk, P.T.L. van, Schneeberger, P.M., Heimeriks, K., Boland, G.J., Karagiannis, I., Geraedts, J., Ruijs, W.L.M., Wijk, P.T.L. van, Schneeberger, P.M., Heimeriks, K., Boland, G.J., Karagiannis, I., Geraedts, J., and Ruijs, W.L.M.

Abstract

1 juni 2010, Contains fulltext : 87220.pdf (publisher's version ) (Closed access), BACKGROUND: To make proper evaluation of prevention policies possible, data on the incidence and associated medical costs of occupational blood exposure accidents in the Netherlands are needed. METHODS: Descriptive analysis of blood exposure accidents and risk estimates for occupational groups. Costs of handling accidents were calculated. RESULTS: Each year, an estimated 13,000-15,000 blood exposure accidents are reported in the Netherlands, 95% in occupational settings. Hepatitis B (HBV) vaccination is offered free of charge only to people in risk groups, the seroprevalence of HBV, hepatitis C (HCV) and human immunodeficiency virus (HIV) is low and few infections are related to blood exposure accidents. High-risk accidents occur mainly in hospitals. In nursing homes and home care settings, the majority of the accidents are low-risk. Limited data are available about occurrence of accidents in other occupational groups. Associated medical costs from occupational blood exposure accidents are mainly determined by the initial risk management. CONCLUSIONS: Accidents must be managed effectively to prevent infection and reduce anxiety in injured employees. While strategies to reduce HCV and HIV infection should be primarily aimed at reducing the occurrence of high-risk accidents, vaccination can prevent HBV infection and cut the costs of handling low-risk accidents. The implementation of vaccination strategies, safe working policies and the proper use of safe equipment should be monitored better.

Published
2010

23. Mumps in a community with low vaccination coverage in the Netherlands.

Author

Karagiannis, I., Lier, A. van, Binnendijk, R.S. van, Ruijs, H., Fanoy, E., Conyn-van Spaendonck, M.A., Melker, H. de, Hahne, S., Karagiannis, I., Lier, A. van, Binnendijk, R.S. van, Ruijs, H., Fanoy, E., Conyn-van Spaendonck, M.A., Melker, H. de, and Hahne, S.

Abstract

Contains fulltext : 164841.pdf (publisher's version ) (Open Access)

Published
2008

24. Prikaccidenten in de arbeidssituatie

Author

LCI, Ruijs WLM, Wijk PThL van, Heimeriks CT, Boland GJ, Karagiannis I, Geraedts J, LCI, Ruijs WLM, Wijk PThL van, Heimeriks CT, Boland GJ, Karagiannis I, and Geraedts J

Published
2008

36. Current measles outbreak in Serbia: a preliminary report

Author

Seguliev, Z, primary, Đurić, P, additional, Petrovic, V, additional, Stefanovic, S, additional, Ćosić, G, additional, Hrnjakovic, I C, additional, Milošević, V, additional, Karagiannis, I, additional, Boxall, N, additional, and Jankovic, D, additional

Published
2007
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37. An Alternative Formulation of the Dynamic Transmission Error to Study the Oscillations of Automotive Hypoid Gears.

Author

Karagiannis, I. and Theodossiades, S.

Subjects
HYPOID gearing, OSCILLATIONS, ANGULAR velocity, TORQUE, CONTINUATION methods, VEHICLES
Abstract

A new modeling approach on the torsional dynamics of hypoid gear pairs is presented in this work. The current formulation is characterized by an alternative expression of the dynamic transmission error (DTE), accounting for the variation of the effective mesh position. Speed dependent resistive torque is introduced on the gear wheel, enabling the system to reach dynamic equilibrium based on realistic vehicle operating conditions. The above are supplementing past research studies, where simplifications were introduced in the calculation of DTE, while the operating angular velocity was defined a priori. The analysis is accompanied by numerical results, indicating the rich dynamic behavior cap-tured by the new formulation. The dynamic complexity of the system necessitates the iden-tification of the various response regimes. A solution continuation method (software AUTO) is employed to follow the stable/unstable periodic response branches over the operating range of the differential under examination. [ABSTRACT FROM AUTHOR]

Published
2014
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38. Gastroenteritis outbreak during a school excursion in Northern Greece, March 2010.

Author

SIDEROGLOU, T., DETSIS, M., KARAGIANNIS, I., GKOLFINOPOULOU, K., MELLOU, K., CHRISAFIS, A., ATHANASIADOU, C., BONOVAS, S., and PANAGIOTOPOULOS, T.

Subjects
GASTROENTERITIS, DISEASE outbreaks, HIGH school students, SCHOOL field trips
Abstract

OBJECTIVE On 4 March 2010, the Department of Epidemiological Surveillance and Intervention of the Hellenic Centre for Disease Control and Prevention was notified about an outbreak of gastroenteritis among high school pupils who had stayed at a hotel of the Prefecture of Central Macedonia from 11 to 15 February 2010, in the context of a school excursion. The aim of this study was to detect the possible source of the outbreak and to define the mode and the vehicle of disease transmission. METHOD A retrospective cohort study was conducted. Individuals who had participated in the school excursion were interviewed via a structured questionnaire, which covered demographic data and information about the disease and possible exposures. Epidata v3.1 was used for data entry and STATA v11.0 for data analysis. Relative risks (RR) and 95% corresponding confidence intervals (CI) were computed for all the risk factors tested. An association was considered statistically significant when the p value was <0.05. The presence of statistically significant independent associations was examined via multiple logistic regression using backward elimination techniques. Risk factors for which the univariate analysis showed a p value <0.05 and RR >3 were included in the multivariate analysis model. A culture was ordered for one stool sample taken from a student. The Health Directorate conducted an environmental inspection of the hotel's kitchen premises and the procedures followed during food preparation. RESULTS Of the 61 persons who participated in the excursion, 54 were included in the study (88.5%). The attack rate was 27.8%. Univariate analysis showed statistically significant association of the disease with several food items that had been consumed during the pupils' stay at the hotel, but the only statistically significant risk factor derived from the multivariate analysis was the consumption of pasta with carbonara sauce at the dinner of the fourth day (RR=17.5, 95% CI: 2.47-123.8). Results of the stool culture were negative. The environmental investigation detected several deficiencies regarding hygiene measures and some food items that were found inappropriate for consumption were confiscated. CONCLUSIONS Even in cases where the laboratory verification of an outbreak is not possible, the epidemiological investigation of an outbreak of gastroenteritis can be of great use, as it provides information regarding the possible source and the mode of the disease transmission. [ABSTRACT FROM AUTHOR]

Published
2011

39. Outbreak investigation of brucellosis in Thassos, Greece, 2008

Author

Karagiannis I, Mellou K, Gkolfinopoulou K, Dougas G, Theocharopoulos G, Vourvidis D, Ellinas D, Sotolidou M, Papadimitriou T, and Rengina Vorou

Subjects
Adult, Aged, 80 and over, Male, Greece, Incidence, Food Contamination, Middle Aged, Risk Assessment, Brucellosis, Disease Outbreaks, Foodborne Diseases, Cheese, Risk Factors, Case-Control Studies, Population Surveillance, Brucella melitensis, Humans, Female, Aged
Abstract

In spring 2008, the Hellenic Center for Disease Control and Prevention was notified about human brucellosis cases in Thassos, a Greek island that had been up to that point under a brucellosis eradication programme. Following the verification of the outbreak a 1:1 case– control study was conducted in the island. The study revealed that consumption of locally produced raw cheese was a risk factor for Brucella melitensis infection (odds ratio (OR): 15.1, 95% confidence interval (CI): 6.56–34.7). Brucella melitensis biotype 3 was identified in two clinical samples. As a result of the outbreak, the island is no longer officially considered as an area with farms free of brucellosis and is currently under a brucellosis control programme. The investigation of this outbreak demonstrated that control and eradication of brucellosis is not only a question of designing a strategy, but rather of ensuring its continuous, strict implementation. Furthermore, it revealed the lack of appropriate education of the public regarding the risks associated with raw, non heat-treated cheese consumption.

45. Effects of Nutritional Support in Patients with Colorectal Cancer During Chemotherapy

Author

Dobrila-Dintinjana, Renata, Đipalo, Iris, Baraba, Kristina, Magašić, Božica, Štimac, Davor, Dintinjana, Marijan, Senn, H.J., Bruera, E., Glaus, A., Fedorak, Richard, Tytgat Guido, Niwa, Hirohumi, Axon, Anthony, Daniilides, I., and Karagiannis, I.

Subjects
nutritional support, chemotherapy, colorectal cancer
Abstract

Introduction: Cancer cachexia occurs in significant number of patients (pts) with cancer. Benefit of nutrition support still remains unclear. We aimed to examine does nutritional support (counselling, oral liquids and megestrol acetate) has influence on nutritional status and symptoms prevalence in patients with colorectal cancer during chemotherapy. Methods: We retrospectively (group A) examined data of 173 patients who were treated in 3 years period without nutritional counselling. Prospectively (group B-215 patients) we offered to our patients individualized nutritional counselling, liquid supplementation, and megestrole acetate. Dietary intake (Nottingham Screening Tool Score) and body weight (Body Mass Index) were monitored before, during and after chemotherapy. The nutritional plan was modified when necessary. Results: During 6 years period we were treating 388 patients with colorectal cancer. Baseline, in both groups about 55% of patients were moderately or severe malnourished. In group A during chemotherapy 140 (80.9%) of patients decreased in weight gain 2-5 kg and 77 (44.5%) were severe malnourished on the end of chemotherapy. In group B, 184 (85.6%) of patients gain weight. The effect of nutritional support was most expressed in the group receiving megestrol acetate and nutritional counseling after 4 weeks of therapy. Average weight gain was 1.5 kg (0.6-2.8). Discussion / Conclusion: With nutritional support, our patients with colorectal cancer gain weight and had better Quality of Life during chemotherapy.

Published
2005

46. Chemotherapy in patients with nonresectable cancer of the biliary system or advanced gallblader cancer : do elderly have benefit at all?

Author

Dobrila-Dintinjana, Renata, Baraba, Kristina, Đipalo, Iris, Štimac, Davor, Dintinjana, Marijan, Daniilides, I., and Karagiannis, I.

Subjects
chemotherapy, nonresectable cancer of the biliary system or advanced gallblader cancer, elderly
Abstract

Adenocarcinomas of the bile ducts (BSCa) and gallblader (GBCa) are highly malignant neoplasms with a very poor prognosis. Chemotherapy (cht) plays only a palliative role and responses are transient without prolonged survival. Aim of the study was to evaluate effectiveness of gemcitabine(G) and cisplatin(CP) combination protocol in achieving Clinical Benefit Response(CBR) for patients (pts) with nonresectable BSCa and with advanced GBCa and to evaluate the differences between younger and elderly patients. For this type of tumors we took 60 years as bordeline for elderly. During five years period we cured 38 patients with BSCa and GBCa with mean age of 52, 4+4, 8 years. There was 23 females with mean age of 50, 2+3, 8 years, and 15 men with mean age 53, 7+4, 3 years. In the group of elderly there was 9 females with mean age of 61, 8+2, 9 years, and 6 men with mean age of 62, 4+2, 9 years. 25 patients (65, 8%) had locally advanced disease and 13 patients (34, 2%) metastatic disease. Patients achieved G 1000 mg/m2 intravenous once per week for seven times. CP 100 mg/m2 iv was administered at day 1, 15, 29 and 43. Number of applicated cycles was 1-10 (median 4 cycles). Partial response rate achieved 22 patients-57, 9%. 36 patients-94, 7% achieved CBR. Pain measured at VAS scale before cht was 5, 1 and after 1st cht cycle 2, 1. Karnofsky Performance Status before chemotherapy was 62, 4%, and after 1st cycle 78, 8%. Median duration Clinical Benefit was 21 weeks. 29 patients (76, 3%) developed fatigue gradus II-III (WHO) ; 20 patients (52, 6%) expressed nausea gradus II (WHO) ; elderly had stronger fatigue (gradus III) versus younger ; also more serious leucopenia and trombocitopenia (gradus III) than younger (gradus II). There was no difference between younger and elderly patients in number of applicated cycles ; also no difference in achieving partial response rate and CBR. There was difference in developing side effects ; elderly had more serious fatigue, leucopenia and trombocitopenia than younger. This results indicate that the treatment of GBCa and BSCa with gemcitabine and cisplatinum is effective and well tolerated also to elderly patients and leads to Clinical Benefit for both groups. The role of chemotherapy in this malignancies is palliation and achieving better Quality of Life more than prolonging survival time.

Published
2005

47. Toxic and Microbiological Effects of Iron Oxide and Silver Nanoparticles as Additives on Extended Ram Semen.

Author

Tsakmakidis IA, Samaras T, Anastasiadou S, Basioura A, Ntemka A, Michos I, Simeonidis K, Karagiannis I, Tsousis G, Angelakeris M, and Boscos CM

Abstract

The aim of the study was to investigate the effect of iron oxide (Fe) and silver (Ag) nanoparticles (NPs) on ram semen. A skim milk extender without antibiotics was used as a diluent of 21 ejaculates (8 rams; 2-3 ejaculates/ram). The groups of control (C; semen without NPs), Fe NPs (3.072 mg Fe 3 O 4 /mL semen), and Ag NPs (2.048 mg Ag-Fe/mL semen) were incubated (15 °C; 30 min), and then a magnetic field was used for NPs' removal. Standard microbiological procedures were performed for all groups. Post-treated samples were stored (15 °C) for 24 h, and sperm variables (kinetics by computer assisted sperm analysis (CASA); viability; morphology; HOST; DNA integrity) were evaluated at 6 and 24 h. Semen data were analyzed by a mixed model for repeated measures and microbiological data with Student's t -test for paired samples. At 6 h of storage, VCL and rapid movement-spermatozoa, and at 24 h, total/progressive motility and amplitude of lateral head displacement (ALH) were significantly decreased in group Ag compared to control. In group Fe, progressive/rapid movement-spermatozoa were significantly lower compared to control after 24 h of storage. Only in group Ag was a significant reduction of total bacterial count revealed. In conclusion, the examined Fe NPs demonstrated slight antibacterial effect, while the examined Ag NPs provided higher antibacterial properties accompanied by cytotoxicity.

Published
2021
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48. Iron Oxide Nanoparticles as an Alternative to Antibiotics Additive on Extended Boar Semen.

Author

Tsakmakidis IA, Samaras T, Anastasiadou S, Basioura A, Ntemka A, Michos I, Simeonidis K, Karagiannis I, Tsousis G, Angelakeris M, and Boscos CM

Abstract

This study examined the effect of Fe 3 O 4 nanoparticles on boar semen. Beltsville thawing solution without antibiotics was used to extend ejaculates from 5 boars (4 ejaculates/boar). Semen samples of control group (C) and group with Fe 3 O 4 (Fe; 0.192 mg/mL semen) were incubated under routine boar semen storage temperature (17 °C) for 0.5 h and nanoparticles were removed by a magnetic field. Before and after treatment, aliquots of all groups were cultured using standard microbiological methods. The samples after treatment were stored (17 °C) for 48 h and sperm parameters (computer-assisted sperm analyzer (CASA) variables; morphology; viability; hypo-osmotic swelling test (HOST); DNA integrity) were evaluated at storage times 0, 24, 48 h. Semen data were analyzed by a repeated measures mixed model and microbial data with Student's t-test for paired samples. Regarding CASA parameters, Fe group did not differ from C at any time point. In group C, total motility after 24 h and progressive motility after 48 h of storage decreased significantly compared to 0 h. In group Fe, linearity (LIN) after 48 h and head abnormalities after 24 h of storage increased significantly compared to 0 h. The microbiological results revealed a significant reduction of the bacterial load in group Fe compared to control at both 24 and 48 h. In conclusion, the use of Fe 3 O 4 nanoparticles during semen processing provided a slight anti-microbiological effect with no adverse effects on sperm characteristics.

Published
2020
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49. Outbreak of uncommon O4 non-agglutinating Salmonella typhimurium linked to minced pork, Saxony-Anhalt, Germany, January to April 2013.

Author

Alt K, Simon S, Helmeke C, Kohlstock C, Prager R, Tietze E, Rabsch W, Karagiannis I, Werber D, Frank C, and Fruth A

Subjects
Adult, Aged, Case-Control Studies, Food Safety, Germany epidemiology, Humans, Male, Middle Aged, Phenotype, Salmonella Food Poisoning microbiology, Salmonella typhimurium isolation & purification, Young Adult, Disease Outbreaks, Food Handling, Red Meat microbiology, Salmonella Food Poisoning epidemiology, Salmonella typhimurium physiology
Abstract

Introduction: In January 2013, the National Reference Centre for Salmonella (NRC) detected a salmonellosis cluster in Saxony-Anhalt, Germany, caused by uncommon O4 non-agglutinating, monophasic Salmonella (S.) Typhimurium DT193. Circulating predominant monophasic S. Typhimurium DT193 clones typically display resistance phenotype ASSuT. We investigated common exposures to control the outbreak, and conducted microbiological investigations to assess the strains' phenotype., Methods: We conducted a case-control study defining cases as persons living or working in Saxony-Anhalt diagnosed with the O4 non-agglutinating strain between January and March 2013. We selected two controls contemporarily reported with norovirus infection, frequency-matched on residence and age group, per case. We interviewed regarding food consumption, especially pork and its place of purchase. We calculated odds ratios (ORs) with 95% confidence intervals (95% CI) using logistic regression. The NRC investigated human and food isolates by PCR, SDS-PAGE, MLST, PFGE, MLVA and susceptibility testing., Results: Altogether, 68 O4 non-agglutinating human isolates were confirmed between January and April 2013. Of those, 61 were assigned to the outbreak (median age 57 years, 44% female); 83% cases ≥ 60 years were hospitalized. Eating raw minced pork from butcheries within 3 days was associated with disease (31 cases, 28 controls; OR adjusted for sex: 3.6; 95% CI: 1.0-13). Phage type DT193 and MLST ST34 were assigned, and isolates' lipopolysaccharide (LPS) matched control strains. Isolates linked to Saxony-Anhalt exhibited PFGE type 5. ASSuT- and ACSSuT phenotype proportions were 34 and 39% respectively; 54% were resistant to chloramphenicol. Three pork isolates matched the outbreak strain., Discussion: Raw minced pork was the most likely infection vehicle in this first reported outbreak caused by O4 non-agglutinating, mostly chloramphenicol-resistant S. Typhimurium DT193. High hospitalization proportions demand awareness on the risk of consumption of raw pork among elderly. LPS analysis indicated O4 expression; therefore, testing with antisera from different lots is recommendable in unexpected agglutination reactions.

Published
2015
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50. Effectiveness of routine and booster pertussis vaccination in children and adolescents, federal state of Brandenburg, Germany, 2002-2012.

Author

Haller S, Dehnert M, Karagiannis I, Rieck T, Siffczyk C, Wichmann O, Poethko-Mueller C, and Hellenbrand W

Subjects
Adolescent, Child, Child, Preschool, Cohort Studies, Germany epidemiology, Humans, Immunization, Secondary statistics & numerical data, Mass Vaccination statistics & numerical data, Pertussis Vaccine administration & dosage, Pertussis Vaccine immunology, Whooping Cough epidemiology, Whooping Cough prevention & control
Abstract

Background: In Germany, whole-cell pertussis vaccines were rapidly replaced by high-concentration acellular pertussis-containing vaccines (3+1 doses from 2 months of age) starting in 1995. Boosters were recommended for 9- to 17-year-olds (2000) and for 5- to 6-year-olds (2006). Pertussis incidence remains high despite rising vaccination coverage (VC). Therefore, we analyzed VC and vaccine effectiveness (VE) in the federal state of Brandenburg., Methods: In a stratified case-cohort analysis, we compared VC of reported pertussis cases with VC assessed in schools and kindergartens in the following strata: Children aged 2-3 years born 2005-2009 (toddlers), 5-7 years born 1995-2006 (pre-schoolers) and 15-16 years born 1995-1996 (adolescents). We calculated VE for primary and booster vaccination using Poisson regression., Results: Four-dose VE decreased from 96.9% in toddlers [95% confidence interval (CI): 72.2-99.3] to 87.8% in pre-schoolers (95% CI: 79.7-92.7) to 81.7% in adolescents (95% CI: 40.6-92.8). Four-dose VE was lower in pre-schoolers born after 1996 (75.4%) than in those born 1995-1996, ~1% and ~21% of whom had received ≥1 dose of whole-cell pertussis vaccines, respectively. VE was higher in pre-schoolers and adolescents who received a booster (92.8%and 96.5%, respectively). However, overall booster VC was only 19% and 76% in these age groups, respectively., Conclusions: We observed high VE of routine pertussis vaccination, with evidence of waning over time and improved VE after booster vaccination. Increased uptake and monitoring of recommended pertussis boosters is urgently recommended to decrease high pertussis morbidity particularly in older children and adolescents.

Published
2015
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