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149 results on '"Karagas, M. R."'

3. Latent Childhood Exposure to Mixtures of Metals and Neurodevelopmental Outcomes in 4–5-Year-Old Children Living in Spain

Author

Notario-Barandiaran, L., primary, Díaz-Coto, S., additional, Jimenez-Redondo, N., additional, Guxens, M., additional, Vrijheid, M., additional, Andiarena, A., additional, Irizar, A., additional, Riaño-Galan, I., additional, Fernández-Somoano, A., additional, Llop, S., additional, Lozano, M., additional, Karagas, M. R., additional, Meharg, A., additional, Carey, M., additional, Meharg, C., additional, Ralphs, K., additional, McCreanor, C., additional, Vioque, J., additional, Martinez-Camblor, P., additional, and Signes-Pastor, A. J., additional

Published
2023
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4. Exposure to metal mixtures and neurodevelopment outcomes in 4-5-year-old children living in Spain

Author

Redondo, N. Jimenez, primary, Coto, S. Díaz, additional, Camblor, P. Martinez, additional, Guxens, M., additional, Vrijheid, M., additional, Andiarena, A., additional, Irizar, A., additional, Galan, I. Riaño, additional, Somoano, A. Fernández, additional, Llop, S., additional, Lozano, M., additional, Karagas, M. R., additional, Vioque, J., additional, Carey, M., additional, Meharg, A., additional, Meharg, C., additional, Ralphs, K., additional, Mccreanor, C., additional, Sendra, E., additional, and Pastor, A. J. Signes, additional

Published
2023
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11. Meta-analysis of epigenome-wide association studies in neonates reveals widespread differential DNA methylation associated with birthweight

Author

Kupers, L. K. (Leanne K.), Monnereau, C. (Claire), Sharp, G. C. (Gemma C.), Yousefi, P. (Paul), Salas, L. A. (Lucas A.), Ghantous, A. (Akram), Page, C. M. (Christian M.), Reese, S. E. (Sarah E.), Wilcox, A. J. (Allen J.), Czamara, D. (Darina), Starling, A. P. (Anne P.), Novoloaca, A. (Alexei), Lent, S. (Samantha), Roy, R. (Ritu), Hoyo, C. (Cathrine), Breton, C. V. (Carrie, V), Allard, C. (Catherine), Just, A. C. (Allan C.), Bakulski, K. M. (Kelly M.), Holloway, J. W. (John W.), Everson, T. M. (Todd M.), Xu, C.-J. (Cheng-Jian), Huang, R.-C. (Rae-Chi), van der Plaat, D. A. (Diana A.), Wielscher, M. (Matthias), Merid, S. K. (Simon Kebede), Ullemar, V. (Vilhelmina), Rezwan, F. I. (Faisal, I), Lahti, J. (Jari), van Dongen, J. (Jenny), Langie, S. A. (Sabine A. S.), Richardson, T. G. (Tom G.), Magnus, M. C. (Maria C.), Nohr, E. A. (Ellen A.), Xu, Z. (Zongli), Duijts, L. (Liesbeth), Zhao, S. (Shanshan), Zhang, W. (Weiming), Plusquin, M. (Michelle), DeMeo, D. L. (Dawn L.), Solomon, O. (Olivia), Heimovaara, J. H. (Joosje H.), Jima, D. D. (Dereje D.), Gao, L. (Lu), Bustamante, M. (Mariona), Perron, P. (Patrice), Wright, R. O. (Robert O.), Hertz-Picciotto, I. (Irva), Zhang, H. (Hongmei), Karagas, M. R. (Margaret R.), Gehring, U. (Ulrike), Marsit, C. J. (Carmen J.), Beilin, L. J. (Lawrence J.), Vonk, J. M. (Judith M.), Jarvelin, M.-R. (Marjo-Riitta), Bergstrom, A. (Anna), Ortqvist, A. K. (Anne K.), Ewart, S. (Susan), Villa, P. M. (Pia M.), Moore, S. E. (Sophie E.), Willemsen, G. (Gonneke), Standaert, A. R. (Arnout R. L.), Haberg, S. E. (Siri E.), Sorensen, T. I. (Thorkild I. A.), Taylor, J. A. (Jack A.), Raikkonen, K. (Katri), Yang, I. V. (Ivana, V), Kechris, K. (Katerina), Nawrot, T. S. (Tim S.), Silver, M. J. (Matt J.), Gong, Y. Y. (Yun Yun), Richiardi, L. (Lorenzo), Kogevinas, M. (Manolis), Litonjua, A. A. (Augusto A.), Eskenazi, B. (Brenda), Huen, K. (Karen), Mbarek, H. (Hamdi), Maguire, R. L. (Rachel L.), Dwyer, T. (Terence), Vrijheid, M. (Martine), Bouchard, L. (Luigi), Baccarelli, A. A. (Andrea A.), Croen, L. A. (Lisa A.), Karmaus, W. (Wilfried), Anderson, D. (Denise), de Vries, M. (Maaike), Sebert, S. (Sylvain), Kere, J. (Juha), Karlsson, R. (Robert), Arshad, S. H. (Syed Hasan), Hamalainen, E. (Esa), Routledge, M. N. (Michael N.), Boomsma, D. I. (Dorret, I), Feinberg, A. P. (Andrew P.), Newschaffer, C. J. (Craig J.), Govarts, E. (Eva), Moisse, M. (Matthieu), Fallin, M. D. (M. Daniele), Melen, E. (Erik), Prentice, A. M. (Andrew M.), Kajantie, E. (Eero), Almqvist, C. (Catarina), Oken, E. (Emily), Dabelea, D. (Dana), Boezen, H. M. (H. Marike), Melton, P. E. (Phillip E.), Wright, R. J. (Rosalind J.), Koppelman, G. H. (Gerard H.), Trevisi, L. (Letizia), Hivert, M.-F. (Marie-France), Sunyer, J. (Jordi), Munthe-Kaas, M. C. (Monica C.), Murphy, S. K. (Susan K.), Corpeleijn, E. (Eva), Wiemels, J. (Joseph), Holland, N. (Nina), Herceg, Z. (Zdenko), Binder, E. B. (Elisabeth B.), Smith, G. D. (George Davey), Jaddoe, V. W. (Vincent W. V.), Lie, R. T. (Rolv T.), Nystad, W. (Wenche), London, S. J. (Stephanie J.), Lawlor, D. A. (Debbie A.), Relton, C. L. (Caroline L.), Snieder, H. (Harold), Felix, J. F. (Janine F.), Kupers, L. K. (Leanne K.), Monnereau, C. (Claire), Sharp, G. C. (Gemma C.), Yousefi, P. (Paul), Salas, L. A. (Lucas A.), Ghantous, A. (Akram), Page, C. M. (Christian M.), Reese, S. E. (Sarah E.), Wilcox, A. J. (Allen J.), Czamara, D. (Darina), Starling, A. P. (Anne P.), Novoloaca, A. (Alexei), Lent, S. (Samantha), Roy, R. (Ritu), Hoyo, C. (Cathrine), Breton, C. V. (Carrie, V), Allard, C. (Catherine), Just, A. C. (Allan C.), Bakulski, K. M. (Kelly M.), Holloway, J. W. (John W.), Everson, T. M. (Todd M.), Xu, C.-J. (Cheng-Jian), Huang, R.-C. (Rae-Chi), van der Plaat, D. A. (Diana A.), Wielscher, M. (Matthias), Merid, S. K. (Simon Kebede), Ullemar, V. (Vilhelmina), Rezwan, F. I. (Faisal, I), Lahti, J. (Jari), van Dongen, J. (Jenny), Langie, S. A. (Sabine A. S.), Richardson, T. G. (Tom G.), Magnus, M. C. (Maria C.), Nohr, E. A. (Ellen A.), Xu, Z. (Zongli), Duijts, L. (Liesbeth), Zhao, S. (Shanshan), Zhang, W. (Weiming), Plusquin, M. (Michelle), DeMeo, D. L. (Dawn L.), Solomon, O. (Olivia), Heimovaara, J. H. (Joosje H.), Jima, D. D. (Dereje D.), Gao, L. (Lu), Bustamante, M. (Mariona), Perron, P. (Patrice), Wright, R. O. (Robert O.), Hertz-Picciotto, I. (Irva), Zhang, H. (Hongmei), Karagas, M. R. (Margaret R.), Gehring, U. (Ulrike), Marsit, C. J. (Carmen J.), Beilin, L. J. (Lawrence J.), Vonk, J. M. (Judith M.), Jarvelin, M.-R. (Marjo-Riitta), Bergstrom, A. (Anna), Ortqvist, A. K. (Anne K.), Ewart, S. (Susan), Villa, P. M. (Pia M.), Moore, S. E. (Sophie E.), Willemsen, G. (Gonneke), Standaert, A. R. (Arnout R. L.), Haberg, S. E. (Siri E.), Sorensen, T. I. (Thorkild I. A.), Taylor, J. A. (Jack A.), Raikkonen, K. (Katri), Yang, I. V. (Ivana, V), Kechris, K. (Katerina), Nawrot, T. S. (Tim S.), Silver, M. J. (Matt J.), Gong, Y. Y. (Yun Yun), Richiardi, L. (Lorenzo), Kogevinas, M. (Manolis), Litonjua, A. A. (Augusto A.), Eskenazi, B. (Brenda), Huen, K. (Karen), Mbarek, H. (Hamdi), Maguire, R. L. (Rachel L.), Dwyer, T. (Terence), Vrijheid, M. (Martine), Bouchard, L. (Luigi), Baccarelli, A. A. (Andrea A.), Croen, L. A. (Lisa A.), Karmaus, W. (Wilfried), Anderson, D. (Denise), de Vries, M. (Maaike), Sebert, S. (Sylvain), Kere, J. (Juha), Karlsson, R. (Robert), Arshad, S. H. (Syed Hasan), Hamalainen, E. (Esa), Routledge, M. N. (Michael N.), Boomsma, D. I. (Dorret, I), Feinberg, A. P. (Andrew P.), Newschaffer, C. J. (Craig J.), Govarts, E. (Eva), Moisse, M. (Matthieu), Fallin, M. D. (M. Daniele), Melen, E. (Erik), Prentice, A. M. (Andrew M.), Kajantie, E. (Eero), Almqvist, C. (Catarina), Oken, E. (Emily), Dabelea, D. (Dana), Boezen, H. M. (H. Marike), Melton, P. E. (Phillip E.), Wright, R. J. (Rosalind J.), Koppelman, G. H. (Gerard H.), Trevisi, L. (Letizia), Hivert, M.-F. (Marie-France), Sunyer, J. (Jordi), Munthe-Kaas, M. C. (Monica C.), Murphy, S. K. (Susan K.), Corpeleijn, E. (Eva), Wiemels, J. (Joseph), Holland, N. (Nina), Herceg, Z. (Zdenko), Binder, E. B. (Elisabeth B.), Smith, G. D. (George Davey), Jaddoe, V. W. (Vincent W. V.), Lie, R. T. (Rolv T.), Nystad, W. (Wenche), London, S. J. (Stephanie J.), Lawlor, D. A. (Debbie A.), Relton, C. L. (Caroline L.), Snieder, H. (Harold), and Felix, J. F. (Janine F.)

Abstract

Birthweight is associated with health outcomes across the life course, DNA methylation may be an underlying mechanism. In this meta-analysis of epigenome-wide association studies of 8,825 neonates from 24 birth cohorts in the Pregnancy And Childhood Epigenetics Consortium, we find that DNA methylation in neonatal blood is associated with birthweight at 914 sites, with a difference in birthweight ranging from −183 to 178 grams per 10% increase in methylation (PBonferroni < 1.06 x 10−7). In additional analyses in 7,278 participants, <1.3% of birthweight-associated differential methylation is also observed in childhood and adolescence, but not adulthood. Birthweight-related CpGs overlap with some Bonferroni-significant CpGs that were previously reported to be related to maternal smoking (55/914, p = 6.12 x 10−74) and BMI in pregnancy (3/914, p = 1.13x10−3), but not with those related to folate levels in pregnancy. Whether the associations that we observe are causal or explained by confounding or fetal growth influencing DNA methylation (i.e. reverse causality) requires further research.

Published
2019

12. Cohort profile:pregnancy and childhood epigenetics (PACE) consortium

Author

Felix, J. F. (Janine F.), Joubert, B. R. (Bonnie R.), Baccarelli, A. A. (Andrea A.), Sharp, G. C. (Gemma C.), Almqvist, C. (Catarina), Annesi-Maesano, I. (Isabella), Arshad, H. (Hasan), Baiz, N. (Nour), Bakermans-Kranenburg, M. J. (Marian J.), Bakulski, K. M. (Kelly M.), Binder, E. B. (Elisabeth B.), Bouchard, L. (Luigi), Breton, C. V. (Carrie V.), Brunekreef, B. (Bert), Brunst, K. J. (Kelly J.), Burchard, E. G. (Esteban G.), Bustamante, M. (Mariona), Chatzi, L. (Leda), Munthe-Kaas, M. C. (Monica Cheng), Corpeleijn, E. (Eva), Czamara, D. (Darina), Dabelea, D. (Dana), Smith, G. D. (George Davey), De Boever, P. (Patrick), Duijts, L. (Liesbeth), Dwyer, T. (Terence), Eng, C. (Celeste), Eskenazi, B. (Brenda), Everson, T. M. (Todd M.), Falahi, F. (Fahimeh), Fallin, M. D. (M. Daniele), Farchi, S. (Sara), Fernandez, M. F. (Mariana F.), Gao, L. (Lu), Gaunt, T. R. (Tom R.), Ghantous, A. (Akram), Gillman, M. W. (Matthew W.), Gonseth, S. (Semira), Grote, V. (Veit), Gruzieva, O. (Olena), Haberg, S. E. (Siri E.), Herceg, Z. (Zdenko), Hivert, M.-F. (Marie-France), Holland, N. (Nina), Holloway, J. W. (John W.), Hoyo, C. (Cathrine), Hu, D. (Donglei), Huang, R.-C. (Rae-Chi), Huen, K. (Karen), Järvelin, M.-R. (Marjo-Riitta), Jima, D. D. (Dereje D.), Just, A. C. (Allan C.), Karagas, M. R. (Margaret R.), Karlsson, R. (Robert), Karmaus, W. (Wilfried), Kechris, K. J. (Katerina J.), Kere, J. (Juha), Kogevinas, M. (Manolis), Koletzko, B. (Berthold), Koppelman, G. H. (Gerard H.), Kupers, L. K. (Leanne K.), Ladd-Acosta, C. (Christine), Lahti, J. (Jari), Lambrechts, N. (Nathalie), Langie, S. A. (Sabine A. S.), Lie, R. T. (Rolv T.), Liu, A. H. (Andrew H.), Magnus, M. C. (Maria C.), Magnus, P. (Per), Maguire, R. L. (Rachel L.), Marsit, C. J. (Carmen J.), McArdle, W. (Wendy), Melen, E. (Erik), Melton, P. (Phillip), Murphy, S. K. (Susan K.), Nawrot, T. S. (Tim S.), Nistico, L. (Lorenza), Nohr, E. A. (Ellen A.), Nordlund, B. (Bjorn), Nystad, W. (Wenche), Oh, S. S. (Sam S.), Oken, E. (Emily), Page, C. M. (Christian M.), Perron, P. (Patrice), Pershagen, G. (Goran), Pizzi, C. (Costanza), Plusquin, M. (Michelle), Raikkonen, K. (Katri), Reese, S. E. (Sarah E.), Reischl, E. (Eva), Richiardi, L. (Lorenzo), Ring, S. (Susan), Roy, R. P. (Ritu P.), Rzehak, P. (Peter), Schoeters, G. (Greet), Schwartz, D. A. (David A.), Sebert, S. (Sylvain), Snieder, H. (Harold), Sorensen, T. I. (Thorkild I. A.), Starling, A. P. (Anne P.), Sunyer, J. (Jordi), ATaylor, J. (Jack), Tiemeier, H. (Henning), Ullemar, V. (Vilhelmina), Vafeiadi, M. (Marina), Van Ijzendoorn, M. H. (Marinus H.), Vonk, J. M. (Judith M.), Vriens, A. (Annette), Vrijheid, M. (Martine), Wang, P. (Pei), Wiemels, J. L. (Joseph L.), Wilcox, A. J. (Allen J.), Wright, R. J. (Rosalind J.), Xu, C.-J. (Cheng-Jian), Xu, Z. (Zongli), Yang, I. V. (Ivana V.), Yousefi, P. (Paul), Zhang, H. (Hongmei), Zhang, W. (Weiming), Zhao, S. (Shanshan), Agha, G. (Golareh), Relton, C. L. (Caroline L.), Jaddoe, V. W. (Vincent W. V.), London, S. J. (Stephanie J.), Felix, J. F. (Janine F.), Joubert, B. R. (Bonnie R.), Baccarelli, A. A. (Andrea A.), Sharp, G. C. (Gemma C.), Almqvist, C. (Catarina), Annesi-Maesano, I. (Isabella), Arshad, H. (Hasan), Baiz, N. (Nour), Bakermans-Kranenburg, M. J. (Marian J.), Bakulski, K. M. (Kelly M.), Binder, E. B. (Elisabeth B.), Bouchard, L. (Luigi), Breton, C. V. (Carrie V.), Brunekreef, B. (Bert), Brunst, K. J. (Kelly J.), Burchard, E. G. (Esteban G.), Bustamante, M. (Mariona), Chatzi, L. (Leda), Munthe-Kaas, M. C. (Monica Cheng), Corpeleijn, E. (Eva), Czamara, D. (Darina), Dabelea, D. (Dana), Smith, G. D. (George Davey), De Boever, P. (Patrick), Duijts, L. (Liesbeth), Dwyer, T. (Terence), Eng, C. (Celeste), Eskenazi, B. (Brenda), Everson, T. M. (Todd M.), Falahi, F. (Fahimeh), Fallin, M. D. (M. Daniele), Farchi, S. (Sara), Fernandez, M. F. (Mariana F.), Gao, L. (Lu), Gaunt, T. R. (Tom R.), Ghantous, A. (Akram), Gillman, M. W. (Matthew W.), Gonseth, S. (Semira), Grote, V. (Veit), Gruzieva, O. (Olena), Haberg, S. E. (Siri E.), Herceg, Z. (Zdenko), Hivert, M.-F. (Marie-France), Holland, N. (Nina), Holloway, J. W. (John W.), Hoyo, C. (Cathrine), Hu, D. (Donglei), Huang, R.-C. (Rae-Chi), Huen, K. (Karen), Järvelin, M.-R. (Marjo-Riitta), Jima, D. D. (Dereje D.), Just, A. C. (Allan C.), Karagas, M. R. (Margaret R.), Karlsson, R. (Robert), Karmaus, W. (Wilfried), Kechris, K. J. (Katerina J.), Kere, J. (Juha), Kogevinas, M. (Manolis), Koletzko, B. (Berthold), Koppelman, G. H. (Gerard H.), Kupers, L. K. (Leanne K.), Ladd-Acosta, C. (Christine), Lahti, J. (Jari), Lambrechts, N. (Nathalie), Langie, S. A. (Sabine A. S.), Lie, R. T. (Rolv T.), Liu, A. H. (Andrew H.), Magnus, M. C. (Maria C.), Magnus, P. (Per), Maguire, R. L. (Rachel L.), Marsit, C. J. (Carmen J.), McArdle, W. (Wendy), Melen, E. (Erik), Melton, P. (Phillip), Murphy, S. K. (Susan K.), Nawrot, T. S. (Tim S.), Nistico, L. (Lorenza), Nohr, E. A. (Ellen A.), Nordlund, B. (Bjorn), Nystad, W. (Wenche), Oh, S. S. (Sam S.), Oken, E. (Emily), Page, C. M. (Christian M.), Perron, P. (Patrice), Pershagen, G. (Goran), Pizzi, C. (Costanza), Plusquin, M. (Michelle), Raikkonen, K. (Katri), Reese, S. E. (Sarah E.), Reischl, E. (Eva), Richiardi, L. (Lorenzo), Ring, S. (Susan), Roy, R. P. (Ritu P.), Rzehak, P. (Peter), Schoeters, G. (Greet), Schwartz, D. A. (David A.), Sebert, S. (Sylvain), Snieder, H. (Harold), Sorensen, T. I. (Thorkild I. A.), Starling, A. P. (Anne P.), Sunyer, J. (Jordi), ATaylor, J. (Jack), Tiemeier, H. (Henning), Ullemar, V. (Vilhelmina), Vafeiadi, M. (Marina), Van Ijzendoorn, M. H. (Marinus H.), Vonk, J. M. (Judith M.), Vriens, A. (Annette), Vrijheid, M. (Martine), Wang, P. (Pei), Wiemels, J. L. (Joseph L.), Wilcox, A. J. (Allen J.), Wright, R. J. (Rosalind J.), Xu, C.-J. (Cheng-Jian), Xu, Z. (Zongli), Yang, I. V. (Ivana V.), Yousefi, P. (Paul), Zhang, H. (Hongmei), Zhang, W. (Weiming), Zhao, S. (Shanshan), Agha, G. (Golareh), Relton, C. L. (Caroline L.), Jaddoe, V. W. (Vincent W. V.), and London, S. J. (Stephanie J.)

Published
2018

13. Risk of basal cell carcinoma in a randomized clinical trial of aspirin and folic acid for the prevention of colorectal adenomas.

Author

Passarelli, M. N., Barry, E. L., Zhang, D., Gangar, P., Rees, J. R., Bresalier, R. S., McKeown‐Eyssen, G., Karagas, M. R., and Baron, J. A.

Subjects
ASPIRIN, ADENOMA, CONFIDENCE intervals, CLINICAL trials, BASAL cell carcinoma
Abstract

Summary: Background: Aspirin may reduce the risk of several types of cancer. Objectives: To evaluate if folic acid is associated with risk of basal cell carcinoma (BCC). Methods: BCC incidence was evaluated in a randomized, double‐blind, placebo‐controlled clinical trial of aspirin (81 mg daily or 325 mg daily for ~3 years) and/or folic acid (1 mg daily for ~6 years) for the prevention of colorectal adenomas among 1121 participants with a previous adenoma. BCC was confirmed by blinded review of pathology reports. Results: One hundred and four of 958 non‐Hispanic white participants were diagnosed with BCC over a median follow‐up of 13·5 years. Cumulative incidence of BCC was 12% [95% confidence interval (CI) 7–17] for placebo, 16% (95% CI 11–21) for 81 mg aspirin daily and 15% (95% CI 10–20) for 325 mg aspirin daily [hazard ratio (HR) for any aspirin 1·45 (95% CI 0·93–2·26); HR for 81 mg daily 1·57 (95% CI 0·96–2·56); HR for 325 mg daily 1·33 (95% CI 0·80–2·20)]. BCC risk was higher with aspirin use in those without previous skin cancer but lower with aspirin use in those with previous skin cancer (Pinteraction = 0·02 for 81 mg aspirin daily; Pinteraction = 0·03 for 325 mg aspirin daily). Folic acid supplementation was unrelated to BCC incidence (HR 0·85; 95% CI 0·57–1·27). Conclusions: Neither aspirin nor folic acid treatment had a statistically significant effect on risk of BCC. Subgroup analysis suggested that chemopreventive effects of nonsteroidal anti‐inflammatory drugs may be specific to those at high risk for BCC. [ABSTRACT FROM AUTHOR]

Published
2018
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17. Genome-wide interaction study of smoking and bladder cancer risk

Author

Figueroa, J. D., primary, Han, S. S., additional, Garcia-Closas, M., additional, Baris, D., additional, Jacobs, E. J., additional, Kogevinas, M., additional, Schwenn, M., additional, Malats, N., additional, Johnson, A., additional, Purdue, M. P., additional, Caporaso, N., additional, Landi, M. T., additional, Prokunina-Olsson, L., additional, Wang, Z., additional, Hutchinson, A., additional, Burdette, L., additional, Wheeler, W., additional, Vineis, P., additional, Siddiq, A., additional, Cortessis, V. K., additional, Kooperberg, C., additional, Cussenot, O., additional, Benhamou, S., additional, Prescott, J., additional, Porru, S., additional, Bueno-de-Mesquita, H. B., additional, Trichopoulos, D., additional, Ljungberg, B., additional, Clavel-Chapelon, F., additional, Weiderpass, E., additional, Krogh, V., additional, Dorronsoro, M., additional, Travis, R., additional, Tjonneland, A., additional, Brenan, P., additional, Chang-Claude, J., additional, Riboli, E., additional, Conti, D., additional, Gago-Dominguez, M., additional, Stern, M. C., additional, Pike, M. C., additional, Van Den Berg, D., additional, Yuan, J.-M., additional, Hohensee, C., additional, Rodabough, R., additional, Cancel-Tassin, G., additional, Roupret, M., additional, Comperat, E., additional, Chen, C., additional, De Vivo, I., additional, Giovannucci, E., additional, Hunter, D. J., additional, Kraft, P., additional, Lindstrom, S., additional, Carta, A., additional, Pavanello, S., additional, Arici, C., additional, Mastrangelo, G., additional, Karagas, M. R., additional, Schned, A., additional, Armenti, K. R., additional, Hosain, G. M. M., additional, Haiman, C. A., additional, Fraumeni, J. F., additional, Chanock, S. J., additional, Chatterjee, N., additional, Rothman, N., additional, and Silverman, D. T., additional

Published
2014
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19. Serial Analysis of the Gut and Respiratory Microbiome in Cystic Fibrosis in Infancy: Interaction between Intestinal and Respiratory Tracts and Impact of Nutritional Exposures

Author

Madan, J. C., primary, Koestler, D. C., additional, Stanton, B. A., additional, Davidson, L., additional, Moulton, L. A., additional, Housman, M. L., additional, Moore, J. H., additional, Guill, M. F., additional, Morrison, H. G., additional, Sogin, M. L., additional, Hampton, T. H., additional, Karagas, M. R., additional, Palumbo, P. E., additional, Foster, J. A., additional, Hibberd, P. L., additional, and O’Toole, G. A., additional

Published
2012
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20. Dietary intake of meat, fruits, vegetables, and selective micronutrients and risk of bladder cancer in the New England region of the United States

Author

Wu, J W, primary, Cross, A J, additional, Baris, D, additional, Ward, M H, additional, Karagas, M R, additional, Johnson, A, additional, Schwenn, M, additional, Cherala, S, additional, Colt, J S, additional, Cantor, K P, additional, Rothman, N, additional, Silverman, D T, additional, and Sinha, R, additional

Published
2012
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21. Abstract LB-337: Synergistic effects of twelve common genetic polymorphisms and smoking habits on absolute risk of bladder cancer

Author

García-Closas, M., primary, Rothman, N., additional, Figueroa, J. D., additional, Prokunina-Olsson, L., additional, Han, S., additional, Baris, D., additional, Jacobs, E., additional, Malats, N., additional, Vivo, I. De, additional, Albanes, D., additional, Purdue, M. P., additional, Sharma, S., additional, Fu, Y. P., additional, Kogevinas, M., additional, Wang, Z., additional, Tang, W., additional, Tardón, A., additional, Serra, C., additional, Carrato, A., additional, García-Closas, R., additional, Lloreta, J., additional, Johnson, A., additional, Schwenn, M., additional, Karagas, M. R., additional, Schned, A., additional, Andriole, G., additional, Grubb, R., additional, Black, A., additional, Gapstur, S. M., additional, Thun, M., additional, Diver, W. R., additional, Weinstein, S. J., additional, Virtamo, J., additional, Hunter, D. J., additional, Caporaso, N., additional, Landi, M. T., additional, Hutchinson, A., additional, Burdett, L., additional, Jacobs, K. B., additional, Yeager, M., additional, Fraumeni, J. F., additional, Chanock, S. J., additional, Silverman, D. T., additional, and Chatterjee, N., additional

Published
2012
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23. GSTM1 null and NAT2 slow acetylation genotypes, smoking intensity and bladder cancer risk: results from the New England bladder cancer study and NAT2 meta-analysis

Author

Moore, L. E., primary, Baris, D. R., additional, Figueroa, J. D., additional, Garcia-Closas, M., additional, Karagas, M. R., additional, Schwenn, M. R., additional, Johnson, A. T., additional, Lubin, J. H., additional, Hein, D. W., additional, Dagnall, C. L., additional, Colt, J. S., additional, Kida, M., additional, Jones, M. A., additional, Schned, A. R., additional, Cherala, S. S., additional, Chanock, S. J., additional, Cantor, K. P., additional, Silverman, D. T., additional, and Rothman, N., additional

Published
2010
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24. Occupation and bladder cancer in a population-based case-control study in Northern New England

Author

Colt, J. S., primary, Karagas, M. R., additional, Schwenn, M., additional, Baris, D., additional, Johnson, A., additional, Stewart, P., additional, Verrill, C., additional, Moore, L. E., additional, Lubin, J., additional, Ward, M. H., additional, Samanic, C., additional, Rothman, N., additional, Cantor, K. P., additional, Beane Freeman, L. E., additional, Schned, A., additional, Cherala, S., additional, and Silverman, D. T., additional

Published
2010
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27. Sun exposure and melanoma risk at different latitudes: a pooled analysis of 5700 cases and 7216 controls

Author

Chang, Y.-m., primary, Barrett, J. H., additional, Bishop, D. T., additional, Armstrong, B. K., additional, Bataille, V., additional, Bergman, W., additional, Berwick, M., additional, Bracci, P. M., additional, Elwood, J. M., additional, Ernstoff, M. S., additional, Gallagher, R. P., additional, Green, A. C., additional, Gruis, N. A., additional, Holly, E. A., additional, Ingvar, C., additional, Kanetsky, P. A., additional, Karagas, M. R., additional, Lee, T. K., additional, Le Marchand, L., additional, Mackie, R. M., additional, Olsson, H., additional, Osterlind, A., additional, Rebbeck, T. R., additional, Sasieni, P., additional, Siskind, V., additional, Swerdlow, A. J., additional, Titus-Ernstoff, L., additional, Zens, M. S., additional, and Newton-Bishop, J. A., additional

Published
2009
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33. Selenium and Colorectal Adenoma: Results of a Pooled Analysis

Author

Jacobs, E. T., primary, Jiang, R., additional, Alberts, D. S., additional, Greenberg, E. R., additional, Gunter, E. W., additional, Karagas, M. R., additional, Lanza, E., additional, Ratnasinghe, L., additional, Reid, M. E., additional, Schatzkin, A., additional, Smith-Warner, S. A., additional, Wallace, K., additional, and Martinez, M. E., additional

Published
2004
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34. Effect of Calcium Supplementation on the Risk of Large Bowel Polyps

Author

Wallace, K., primary, Baron, J. A., additional, Cole, B. F., additional, Sandler, R. S., additional, Karagas, M. R., additional, Beach, M. A., additional, Haile, R. W., additional, Burke, C. A., additional, Pearson, L. H., additional, Mandel, J. S., additional, Rothstein, R., additional, and Snover, D. C., additional

Published
2004
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38. A pooled analysis of 10 case–control studies of melanoma and oral contraceptive use

Author

Karagas, M R, primary, Stukel, T A, additional, Dykes, J, additional, Miglionico, J, additional, Greene, M A, additional, Carey, M, additional, Armstrong, B, additional, Elwood, J M, additional, Gallagher, R P, additional, Green, A, additional, Holly, E A, additional, Kirkpatrick, C S, additional, Mack, T, additional, Østerlind, A, additional, Rosso, S, additional, and Swerdlow, A J, additional

Published
2002
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49. DNA methylation profiles delineate etiologic heterogeneity and clinically important subgroups of bladder cancer.

Author

Wilhelm-Benartzi, C. S., Koestler, D. C., Houseman, E. A., Christensen, B. C., Wiencke, John K., Schned, A. R., Karagas, M. R., Kelsey, K. T., and Marsit, C. J.

Subjects
DNA, METHYLATION, ETIOLOGY of diseases, HETEROGENEITY, BLADDER cancer
Abstract

DNA methylation profiles can be used to define molecular cancer subtypes that may better inform disease etiology and clinical decision-making. This investigation aimed to create DNA methylation profiles of bladder cancer based on CpG methylation from almost 800 cancer-related genes and to then examine the relationship of those profiles with exposures related to risk and clinical characteristics. DNA, derived from formalin-fixed paraffin-embedded tumor samples obtained from incident cases involved in a population-based case-control study of bladder cancer in New Hampshire, was used for methylation profiling on the Illumina GoldenGate Methylation Bead Array. Unsupervised clustering of those loci with the greatest change in methylation between tumor and non-diseased tissue was performed to defined molecular subgroups of disease, and univariate tests of association followed by multinomial logistic regression was used to examine the association between these classes, bladder cancer risk factors and clinical phenotypes. Membership in the two most methylated classes was significantly associated with invasive disease (P < 0.001 for both class 3 and 4). Male gender (P = 0.04) and age >70 years (P = 0.05) was associated with membership in one of the most methylated classes. Finally, average water arsenic levels in the highest percentile predicted membership in an intermediately methylated class of tumors (P = 0.02 for both classes). Exposures and demographic associated with increased risk of bladder cancer specifically associate with particular subgroups of tumors defined by DNA methylation profiling and these subgroups may define more aggressive disease. [ABSTRACT FROM PUBLISHER]

Published
2010
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50. Use of oral glucocorticoids and risk of skin cancer and non-Hodgkin's lymphoma: a population-based case-control study.

Author

Jensen, A. Ø, Thomsen, H. F., Engebjerg, M. C., Olesen, A. B., Friis, S., Karagas, M. R., Sørensen, H. T., Jensen, A Ø, and Sørensen, H T

Subjects
GLUCOCORTICOIDS, ORAL medicine, CANCER risk factors, SKIN cancer, HODGKIN'S disease, BASAL cell carcinoma, COMPARATIVE studies, LYMPHOMAS, RESEARCH methodology, MEDICAL cooperation, MELANOMA, ORAL drug administration, RESEARCH, SKIN tumors, SQUAMOUS cell carcinoma, EVALUATION research, CASE-control method
Abstract

In North Jutland County, Denmark, we investigated whether use of oral glucocorticoids was associated with an increased risk of developing basal cell carcinoma (BCC), squamous cell carcinoma (SCC), malignant melanoma (MM), and non-Hodgkin's lymphoma (NHL). From the Danish Cancer Registry we identified 5422 BCC, 935 SCC, 983 MM, and 481 NHL cases during 1989-2003. Using risk-set sampling we selected four age- and gender-matched population controls for each case from the Civil Registration System. Prescriptions for oral glucocorticoids before diagnosis were obtained from the Prescription Database of North Jutland County on the basis of National Health Service data. We used conditional logistic regression to estimate incidence rate ratios (IRRs), adjusting for chronic medical diseases (information about these were obtained from the National Patient Registry) and use of other immunosuppressants. We found slightly elevated risk estimates for BCC (IRR, 1.15 (95% CI: 1.07-1.25)), SCC (IRR, 1.14 (95% CI: 0.94-1.39)), MM (IRR, 1.15 (95% CI: 0.94-1.41), and NHL (IRR, 1.11 (95% CI: 0.85-1.46)) among users of oral glucocorticoids. Our study supports an overall association between glucocorticoid use and risk of BCC that cannot be explained by the presence of chronic diseases or concomitant use of other immunosuppressants. [ABSTRACT FROM AUTHOR]

Published
2009
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