18 results on '"Karabegović, Irma"'
Search Results
2. Genetic loci and prioritization of genes for kidney function decline derived from a meta-analysis of 62 longitudinal genome-wide association studies
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Gorski, Mathias, Rasheed, Humaira, Teumer, Alexander, Thomas, Laurent F., Graham, Sarah E., Sveinbjornsson, Gardar, Winkler, Thomas W., Günther, Felix, Stark, Klaus J., Chai, Jin-Fang, Tayo, Bamidele O., Wuttke, Matthias, Li, Yong, Tin, Adrienne, Ahluwalia, Tarunveer S., Ärnlöv, Johan, Åsvold, Bjørn Olav, Bakker, Stephan J.L., Banas, Bernhard, Bansal, Nisha, Biggs, Mary L., Biino, Ginevra, Böhnke, Michael, Boerwinkle, Eric, Bottinger, Erwin P., Brenner, Hermann, Brumpton, Ben, Carroll, Robert J., Chaker, Layal, Chalmers, John, Chee, Miao-Li, Chee, Miao-Ling, Cheng, Ching-Yu, Chu, Audrey Y., Ciullo, Marina, Cocca, Massimiliano, Cook, James P., Coresh, Josef, Cusi, Daniele, de Borst, Martin H., Degenhardt, Frauke, Eckardt, Kai-Uwe, Endlich, Karlhans, Evans, Michele K., Feitosa, Mary F., Franke, Andre, Freitag-Wolf, Sandra, Fuchsberger, Christian, Gampawar, Piyush, Gansevoort, Ron T., Ghanbari, Mohsen, Ghasemi, Sahar, Giedraitis, Vilmantas, Gieger, Christian, Gudbjartsson, Daniel F., Hallan, Stein, Hamet, Pavel, Hishida, Asahi, Ho, Kevin, Hofer, Edith, Holleczek, Bernd, Holm, Hilma, Hoppmann, Anselm, Horn, Katrin, Hutri-Kähönen, Nina, Hveem, Kristian, Hwang, Shih-Jen, Ikram, M. Arfan, Josyula, Navya Shilpa, Jung, Bettina, Kähönen, Mika, Karabegović, Irma, Khor, Chiea-Chuen, Koenig, Wolfgang, Kramer, Holly, Krämer, Bernhard K., Kühnel, Brigitte, Kuusisto, Johanna, Laakso, Markku, Lange, Leslie A., Lehtimäki, Terho, Li, Man, Lieb, Wolfgang, Lind, Lars, Lindgren, Cecilia M., Loos, Ruth J.F., Lukas, Mary Ann, Lyytikäinen, Leo-Pekka, Mahajan, Anubha, Matias-Garcia, Pamela R., Meisinger, Christa, Meitinger, Thomas, Melander, Olle, Milaneschi, Yuri, Mishra, Pashupati P., Mononen, Nina, Morris, Andrew P., Mychaleckyj, Josyf C., Nadkarni, Girish N., Naito, Mariko, Nakatochi, Masahiro, Nalls, Mike A., Nauck, Matthias, Nikus, Kjell, Ning, Boting, Nolte, Ilja M., Nutile, Teresa, O’Donoghue, Michelle L., O'Connell, Jeffrey, Olafsson, Isleifur, Orho-Melander, Marju, Parsa, Afshin, Pendergrass, Sarah A., Penninx, Brenda W.J.H., Pirastu, Mario, Preuss, Michael H., Psaty, Bruce M., Raffield, Laura M., Raitakari, Olli T., Rheinberger, Myriam, Rice, Kenneth M., Rizzi, Federica, Rosenkranz, Alexander R., Rossing, Peter, Rotter, Jerome I., Ruggiero, Daniela, Ryan, Kathleen A., Sabanayagam, Charumathi, Salvi, Erika, Schmidt, Helena, Schmidt, Reinhold, Scholz, Markus, Schöttker, Ben, Schulz, Christina-Alexandra, Sedaghat, Sanaz, Shaffer, Christian M., Sieber, Karsten B., Sim, Xueling, Sims, Mario, Snieder, Harold, Stanzick, Kira J., Thorsteinsdottir, Unnur, Stocker, Hannah, Strauch, Konstantin, Stringham, Heather M., Sulem, Patrick, Szymczak, Silke, Taylor, Kent D., Thio, Chris H.L., Tremblay, Johanne, Vaccargiu, Simona, van der Harst, Pim, van der Most, Peter J., Verweij, Niek, Völker, Uwe, Wakai, Kenji, Waldenberger, Melanie, Wallentin, Lars, Wallner, Stefan, Wang, Judy, Waterworth, Dawn M., White, Harvey D., Willer, Cristen J., Wong, Tien-Yin, Woodward, Mark, Yang, Qiong, Yerges-Armstrong, Laura M., Zimmermann, Martina, Zonderman, Alan B., Bergler, Tobias, Stefansson, Kari, Böger, Carsten A., Pattaro, Cristian, Köttgen, Anna, Kronenberg, Florian, and Heid, Iris M.
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- 2022
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3. Plasma circulating microRNAs associated with blood-based immune markers:a population-based study
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Leonard, Samantha, Karabegović, Irma, Ikram, M. Arfan, Ahmad, Shahzad, Ghanbari, Mohsen, Leonard, Samantha, Karabegović, Irma, Ikram, M. Arfan, Ahmad, Shahzad, and Ghanbari, Mohsen
- Abstract
MicroRNAs (miRNAs) are small non-coding RNAs that post-transcriptionally regulate gene expression and different immune-related pathways. There is a great interest in identifying miRNAs involved in immune cell development and function to elucidate the biological mechanisms underlying the immune system, its regulation, and disease. In this study, we aimed to investigate the association of circulating miRNAs with blood cell compositions and blood-based immune markers. Circulating levels of 2083 miRNAs were measured by RNA-sequencing in plasma samples of 1999 participants from the population-based Rotterdam Study collected between 2002 and 2005. Full blood count measurements were performed for absolute granulocyte, platelet, lymphocyte, monocyte, white, and red blood cell counts. Multivariate analyses were performed to test the association of miRNAs with blood cell compositions and immune markers. We evaluated the overlap between predicted target genes of candidate miRNAs associated with immune markers and genes determining the blood immune response markers. First, principal component regression analysis showed that plasma levels of circulating miRNAs were significantly associated with red blood cell, granulocyte, and lymphocyte counts. Second, the cross-sectional analysis identified 210 miRNAs significantly associated (P < 2.82 × 10-5) with neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), and systemic immune-inflammation index. Further genetic look-ups showed that target genes of seven identified miRNAs (miR-1233-3p, miR-149-3p, miR-150-5p, miR-342-3p, miR-34b-3p, miR-4644, and miR-7106-5p) were also previously linked to NLR and PLR markers. Collectively, our study suggests several circulating miRNAs that regulate the innate and adaptive immune systems, providing insight into the pathogenesis of miRNAs in immune-related diseases and paving the way for future clinical applications.
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- 2024
4. Plasma circulating microRNAs associated with blood-based immune markers: a population-based study
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Leonard, Samantha, primary, Karabegović, Irma, additional, Ikram, M Arfan, additional, Ahmad, Shahzad, additional, and Ghanbari, Mohsen, additional
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- 2023
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5. Epigenome-wide association meta-analysis of DNA methylation with coffee and tea consumption
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Karabegović, Irma, Portilla-Fernandez, Eliana, Li, Yang, Ma, Jiantao, Maas, Silvana C. E., Sun, Daokun, Hu, Emily A., Kühnel, Brigitte, Zhang, Yan, Ambatipudi, Srikant, Fiorito, Giovanni, Huang, Jian, Castillo-Fernandez, Juan E., Wiggins, Kerri L., de Klein, Niek, Grioni, Sara, Swenson, Brenton R., Polidoro, Silvia, Treur, Jorien L., Cuenin, Cyrille, Tsai, Pei-Chien, Costeira, Ricardo, Chajes, Veronique, Braun, Kim, Verweij, Niek, Kretschmer, Anja, Franke, Lude, van Meurs, Joyce B. J., Uitterlinden, André G., de Knegt, Robert J., Ikram, M. Arfan, Dehghan, Abbas, Peters, Annette, Schöttker, Ben, Gharib, Sina A., Sotoodehnia, Nona, Bell, Jordana T., Elliott, Paul, Vineis, Paolo, Relton, Caroline, Herceg, Zdenko, Brenner, Hermann, Waldenberger, Melanie, Rebholz, Casey M., Voortman, Trudy, Pan, Qiuwei, Fornage, Myriam, Levy, Daniel, Kayser, Manfred, and Ghanbari, Mohsen
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- 2021
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6. Plasma circulating microRNAs associated with blood-based immune markers: a population-based study.
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Leonard, Samantha, Karabegović, Irma, Ikram, M Arfan, Ahmad, Shahzad, and Ghanbari, Mohsen
- Subjects
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BIOMARKERS , *BLOOD cell count , *PLATELET lymphocyte ratio , *ERYTHROCYTES , *NEUTROPHIL lymphocyte ratio - Abstract
MicroRNAs (miRNAs) are small non-coding RNAs that post-transcriptionally regulate gene expression and different immune-related pathways. There is a great interest in identifying miRNAs involved in immune cell development and function to elucidate the biological mechanisms underlying the immune system, its regulation, and disease. In this study, we aimed to investigate the association of circulating miRNAs with blood cell compositions and blood-based immune markers. Circulating levels of 2083 miRNAs were measured by RNA-sequencing in plasma samples of 1999 participants from the population-based Rotterdam Study collected between 2002 and 2005. Full blood count measurements were performed for absolute granulocyte, platelet, lymphocyte, monocyte, white, and red blood cell counts. Multivariate analyses were performed to test the association of miRNAs with blood cell compositions and immune markers. We evaluated the overlap between predicted target genes of candidate miRNAs associated with immune markers and genes determining the blood immune response markers. First, principal component regression analysis showed that plasma levels of circulating miRNAs were significantly associated with red blood cell, granulocyte, and lymphocyte counts. Second, the cross-sectional analysis identified 210 miRNAs significantly associated (P < 2.82 × 10−5) with neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), and systemic immune-inflammation index. Further genetic look-ups showed that target genes of seven identified miRNAs (miR-1233-3p, miR-149-3p, miR-150-5p, miR-342-3p, miR-34b-3p, miR-4644, and miR-7106-5p) were also previously linked to NLR and PLR markers. Collectively, our study suggests several circulating miRNAs that regulate the innate and adaptive immune systems, providing insight into the pathogenesis of miRNAs in immune-related diseases and paving the way for future clinical applications. MicroRNAs (miRNAs) are emerging as post-transcriptional regulators of gene expression in various biological processes, spurring efforts to identify miRNAs implicated in immune cell development and function, to elucidate the biological mechanisms underlying the immune system, its regulation, and disease. This study measured circulating levels of miRNAs by RNA-sequencing in plasma samples of 1999 participants from the population-based Rotterdam Study. Together, we found several circulating miRNAs with the potential to regulate the innate and adaptive immune systems, providing insights into the pathogenesis of miRNAs in immune-related diseases and paving the way for future clinical applications. Graphical Abstract [ABSTRACT FROM AUTHOR]
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- 2024
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7. DNA methylation at birth and fine motor ability in childhood: an epigenome-wide association study with replication
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Serdarevic, Fadila, primary, Luo, Mannan, additional, Karabegović, Irma, additional, Binter, Anne-Claire, additional, Alemany, Silvia, additional, Mutzel, Ryan, additional, Guxens, Monica, additional, Bustamante, Mariona, additional, Hajdarpasic, Aida, additional, White, Tonya, additional, Felix, Janine F, additional, Cecil, Charlotte A.M., additional, and Tiemeier, Henning, additional
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- 2023
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8. Smoking-related dysregulation of plasma circulating microRNAs:the Rotterdam study
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Karabegović, Irma, Maas, Silvana C.E., Shuai, Yu, Ikram, M. Arfan, Stricker, Bruno, Aerts, Joachim, Brusselle, Guy, Lahousse, Lies, Voortman, Trudy, Ghanbari, Mohsen, Karabegović, Irma, Maas, Silvana C.E., Shuai, Yu, Ikram, M. Arfan, Stricker, Bruno, Aerts, Joachim, Brusselle, Guy, Lahousse, Lies, Voortman, Trudy, and Ghanbari, Mohsen
- Abstract
Background: MicroRNAs (miRNAs) are post-transcriptional regulators of gene expression. Differential miRNA expression, which is widely shown to be associated with the pathogenesis of various diseases, can be influenced by lifestyle factors, including smoking. This study aimed to investigate the plasma miRNA signature of smoking habits, the potential effect of smoking cessation on miRNA levels, and relate the findings with lung cancer incidence. Results: A targeted RNA-sequencing approach measured plasma miRNA levels in 2686 participants from the population-based Rotterdam study cohort. The association between cigarette smoking (current versus never) and 591 well-expressed miRNAs was assessed via adjusted linear regression models, identifying 41 smoking-associated miRNAs that passed the Bonferroni-corrected threshold (P < 0.05/591 = 8.46 × 10–5). Moreover, we found 42 miRNAs with a significant association (P < 8.46 × 10–5) between current (reference group) and former smokers. Then, we used adjusted linear regression models to explore the effect of smoking cessation time on miRNA expression levels. The expression levels of two miRNAs were significantly different within 5 years of cessation (P < 0.05/41 = 1.22 × 10–3) from current smokers, while for cessation time between 5 and 15 years we found 19 miRNAs to be significantly different from current smokers, and finally, 38 miRNAs were significantly different after more than 15 years of cessation time (P < 1.22 × 10–3). These results imply the reversibility of the smoking effect on plasma levels of at least 38 out of the 41 smoking-miRNAs following smoking cessation. Next, we found 8 out of the 41 smoking-related miRNAs to be nominally associated (P < 0.05) with the incidence of lung cancer. Conclusions: This study demonstrates smoking-related dysregulation of plasma miRNAs, which might have a potential for reversibility when comparing different smoking cessati
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- 2023
9. Plasma MicroRNA Signature of Alcohol Consumption: The Rotterdam Study
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Karabegović, Irma, primary, Abozaid, Yasir, additional, Maas, Silvana CE, additional, Labrecque, Jeremy, additional, Bos, Daniel, additional, De Knegt, Robert J, additional, Ikram, M Arfan, additional, Voortman, Trudy, additional, and Ghanbari, Mohsen, additional
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- 2022
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10. Additional file 2 of Smoking-related dysregulation of plasma circulating microRNAs: the Rotterdam study
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Karabegović, Irma, Maas, Silvana C. E., Shuai, Yu, Ikram, M. Arfan, Stricker, Bruno, Aerts, Joachim, Brusselle, Guy, Lahousse, Lies, Voortman, Trudy, and Ghanbari, Mohsen
- Abstract
Additional file 2: Fig. S1. Provides the distribution of the top 10 significantly associated miRNAs with current versus never smoking status; Fig. S2. Provides a Volcano plot depicting the results from current versus former smokers analysis, where current smoking was a reference; Fig. S3. Depicts boxplots of all 41 smoking miRNAs with their expression levels across different smoking cessation categories, while Fig. S4. Depicts the enrichment plot for the smoking associated miRNAs in the KEGG pathways.
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- 2023
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11. Plasma MicroRNA Signature of Alcohol Consumption: The Rotterdam Study
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Karabegović, Irma, Abozaid, Yasir, Maas, Silvana C.E., Labrecque, Jeremy, Bos, Daniel, De knegt, Robert J., Ikram, M.A., Voortman, Trudy, Ghanbari, Mohsen, Karabegović, Irma, Abozaid, Yasir, Maas, Silvana C.E., Labrecque, Jeremy, Bos, Daniel, De knegt, Robert J., Ikram, M.A., Voortman, Trudy, and Ghanbari, Mohsen
- Abstract
Background: MicroRNAs (miRNAs) represent a class of noncoding RNAs that regulate gene expression and are implicated in the pathogenesis of different diseases. Alcohol consumption might affect the expression of miRNAs, which in turn could play a role in risk of diseases.Objectives: We investigated whether plasma concentrations of miRNAs are altered by alcohol consumption. Given the existing evidence showing the link between alcohol and liver diseases, we further explored the extent to which these associations are mediated by miRNAs.Methods: Profiling of plasma miRNAs was conducted using the HTG EdgeSeq miRNA Whole Transcriptome Assay in 1933 participants of the Rotterdam Study. Linear regression was implemented to explore the link between alcohol consumption (glasses/d) and miRNA concentrations, adjusted for age, sex, cohort, BMI, and smoking. Sensitivity analysis for alcohol categories (nondrinkers, light drinkers, and heavy drinkers) was performed, where light drinkers corresponded to 0–2 glasses/d in men and 0–1 glasses/d in women, and heavy drinkers to >2 glasses/d in men and >1 glass/d in women. Moreover, we utilized the alcohol-associated miRNAs to explore their potential mediatory role between alcohol consumption and liver-related traits. Finally, we retrieved putative target genes of identified miRNAs to gain an understanding of the molecular pathways concerning alcohol consumption.Results: Plasma concentrations of miR-193b-3p, miR-122-5p, miR-3937, and miR-4507 were significantly associated with alcohol consumption surpassing the Bonferroni-corrected P Conclusions: This study indicates that alcohol consumption is associated with plasma concentrations of 4 miRNAs. We outline a potential mediatory role of 2 alcohol-associated miRNAs (miR-3937 and miR-122-5p), laying the groundwork for further exploration of miRNAs as potential mediators between lifestyle factors and disease development.
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- 2022
12. Whole-diet interventions and cardiovascular risk factors in postmenopausal women : A systematic review of controlled clinical trials
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Amiri, Mojgan, Karabegović, Irma, van Westing, Anniek C., Verkaar, Auke J.C.F., Beigrezaei, Sara, Lara, Macarena, Bramer, Wichor M., Voortman, Trudy, Amiri, Mojgan, Karabegović, Irma, van Westing, Anniek C., Verkaar, Auke J.C.F., Beigrezaei, Sara, Lara, Macarena, Bramer, Wichor M., and Voortman, Trudy
- Abstract
Objectives: Menopause is accompanied by many metabolic changes, increasing the risk of cardiometabolic diseases. The impact of diet, as a modifiable lifestyle factor, on cardiovascular health in general populations has been well established. The purpose of this systematic review is to summarize the evidence on the effects of whole diet on lipid profile, glycemic indices, and blood pressure in postmenopausal women. Methods: Embase, Medline, Cochrane Central Register of Controlled Trials, and Google Scholar were searched from inception to February 2021. We included controlled clinical trials in postmenopausal women that assessed the effect of a whole-diet intervention on lipid profile, glycemic indices, and/or blood pressure. The risk of bias in individual studies was assessed using RoB 2 and ROBINS-I tools. Summary of evidence: Among 2,134 references, 21 trials met all eligibility criteria. Overall, results were heterogenuous and inconsistent. Compared to control diets, some studies showed that participants experienced improvements in total cholesterol (TC), low-density lipoprotein cholesterol (LDL), systolic blood pressure (SBP), fasting blood sugar (FBS), and apolipoprotein A (Apo-A) after following fat-modified diets, but some adverse effects on triglycerides (TG), very low-density lipoprotein cholesterol (VLDL), lipoprotein(a) (Lp(a)), and high-density lipoprotein cholesterol (HDL) concentrations were also observed. A limited number of trials found some effects of the Paleolithic, weight-loss, plant-based, or energy-restricted diets, or of following American Heart Association recommendations on TG, TC, HDL, insulin, FBS, or insulin resistance. Conclusion: Current evidence suggests that diet may affect levels of some lipid profile markers, glycemic indices, and blood pressure among postmenopausal women. However, due to the large heterogeneity in intervention diets, comparison groups, intervention durations, and population characteristics, findings are inconclusive
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- 2022
13. Whole-diet interventions and cardiovascular risk factors in postmenopausal women:A systematic review of controlled clinical trials
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Amiri, Mojgan, Karabegović, Irma, van Westing, Anniek C., Verkaar, Auke J.C.F., Beigrezaei, Sara, Lara, Macarena, Bramer, Wichor M., Voortman, Trudy, Amiri, Mojgan, Karabegović, Irma, van Westing, Anniek C., Verkaar, Auke J.C.F., Beigrezaei, Sara, Lara, Macarena, Bramer, Wichor M., and Voortman, Trudy
- Abstract
Objectives: Menopause is accompanied by many metabolic changes, increasing the risk of cardiometabolic diseases. The impact of diet, as a modifiable lifestyle factor, on cardiovascular health in general populations has been well established. The purpose of this systematic review is to summarize the evidence on the effects of whole diet on lipid profile, glycemic indices, and blood pressure in postmenopausal women. Methods: Embase, Medline, Cochrane Central Register of Controlled Trials, and Google Scholar were searched from inception to February 2021. We included controlled clinical trials in postmenopausal women that assessed the effect of a whole-diet intervention on lipid profile, glycemic indices, and/or blood pressure. The risk of bias in individual studies was assessed using RoB 2 and ROBINS-I tools. Summary of evidence: Among 2,134 references, 21 trials met all eligibility criteria. Overall, results were heterogenuous and inconsistent. Compared to control diets, some studies showed that participants experienced improvements in total cholesterol (TC), low-density lipoprotein cholesterol (LDL), systolic blood pressure (SBP), fasting blood sugar (FBS), and apolipoprotein A (Apo-A) after following fat-modified diets, but some adverse effects on triglycerides (TG), very low-density lipoprotein cholesterol (VLDL), lipoprotein(a) (Lp(a)), and high-density lipoprotein cholesterol (HDL) concentrations were also observed. A limited number of trials found some effects of the Paleolithic, weight-loss, plant-based, or energy-restricted diets, or of following American Heart Association recommendations on TG, TC, HDL, insulin, FBS, or insulin resistance. Conclusion: Current evidence suggests that diet may affect levels of some lipid profile markers, glycemic indices, and blood pressure among postmenopausal women. However, due to the large heterogeneity in intervention diets, comparison groups, intervention durations, and population characteristics, findings are inconclus
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- 2022
14. Whole-diet interventions and cardiovascular risk factors in postmenopausal women: A systematic review of controlled clinical trials
- Author
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Amiri, Mojgan, primary, Karabegović, Irma, additional, van Westing, Anniek C., additional, Verkaar, Auke J.C.F., additional, Beigrezaei, Sara, additional, Lara, Macarena, additional, Bramer, Wichor M., additional, and Voortman, Trudy, additional
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- 2022
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15. Characterization and Diversity of 243 Complete Human Papillomavirus Genomes in Cervical Swabs Using Next Generation Sequencing
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Latsuzbaia, Ardashel, primary, Wienecke-Baldacchino, Anke, additional, Tapp, Jessica, additional, Arbyn, Marc, additional, Karabegović, Irma, additional, Chen, Zigui, additional, Fischer, Marc, additional, Mühlschlegel, Friedrich, additional, Weyers, Steven, additional, Pesch, Pascale, additional, and Mossong, Joël, additional
- Published
- 2020
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16. Epigenome-wide association meta-analysis of DNA methylation with coffee and tea consumption
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Karabegović, Irma, primary, Portilla-Fernandez, Eliana, additional, Li, Yang, additional, Ma, Jiantao, additional, Maas, Silvana C.E., additional, Sun, Daokun, additional, Hu, Emily A., additional, Kühnel, Brigitte, additional, Zhang, Yan, additional, Ambatipudi, Srikant, additional, Fiorito, Giovanni, additional, Huang, Jian, additional, Castillo-Fernandez, Juan E., additional, Wiggins, Kerri L., additional, de Klein, Niek, additional, Grioni, Sara, additional, Swenson, Brenton R., additional, Polidoro, Silvia, additional, Treur, Jorien L., additional, Cuenin, Cyrille, additional, Tsai, Pei-Chien, additional, Costeira, Ricardo, additional, Chajes, Veronique, additional, Braun, Kim, additional, Verweij, Niek, additional, Kretschmer, Anja, additional, Franke, Lude, additional, van Meurs, Joyce B.J., additional, Uitterlinden, André G., additional, de Knegt, Robert J., additional, Ikram, M. Arfan, additional, Dehghan, Abbas, additional, Peters, Annette, additional, Schöttker, Ben, additional, Gharib, Sina A., additional, Sotoodehnia, Nona, additional, Bell, Jordana T., additional, Elliott, Paul, additional, Vineis, Paolo, additional, Relton, Caroline, additional, Herceg, Zdenko, additional, Brenner, Hermann, additional, Waldenberger, Melanie, additional, Rebholz, Casey M., additional, Voortman, Trudy, additional, Pan, Qiuwei, additional, Fornage, Myriam, additional, Levy, Daniel, additional, Kayser, Manfred, additional, and Ghanbari, Mohsen, additional
- Published
- 2020
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17. Genetic Polymorphism of miR-196a-2 is Associated with Bone Mineral Density (BMD)
- Author
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Karabegović, Irma, primary, Maas, Silvana, additional, Medina-Gomez, Carolina, additional, Zrimšek, Maša, additional, Reppe, Sjur, additional, Gautvik, Kaare, additional, Uitterlinden, André, additional, Rivadeneira, Fernando, additional, and Ghanbari, Mohsen, additional
- Published
- 2017
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18. Plasma MicroRNA Signature of Alcohol Consumption: The Rotterdam Study.
- Author
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Karabegović I, Abozaid Y, Maas SCE, Labrecque J, Bos D, De Knegt RJ, Ikram MA, Voortman T, and Ghanbari M
- Subjects
- Female, Animals, Gene Expression Profiling, Transcriptome, Phenotype, Alcohol Drinking, MicroRNAs metabolism
- Abstract
Background: MicroRNAs (miRNAs) represent a class of noncoding RNAs that regulate gene expression and are implicated in the pathogenesis of different diseases. Alcohol consumption might affect the expression of miRNAs, which in turn could play a role in risk of diseases., Objectives: We investigated whether plasma concentrations of miRNAs are altered by alcohol consumption. Given the existing evidence showing the link between alcohol and liver diseases, we further explored the extent to which these associations are mediated by miRNAs., Methods: Profiling of plasma miRNAs was conducted using the HTG EdgeSeq miRNA Whole Transcriptome Assay in 1933 participants of the Rotterdam Study. Linear regression was implemented to explore the link between alcohol consumption (glasses/d) and miRNA concentrations, adjusted for age, sex, cohort, BMI, and smoking. Sensitivity analysis for alcohol categories (nondrinkers, light drinkers, and heavy drinkers) was performed, where light drinkers corresponded to 0-2 glasses/d in men and 0-1 glasses/d in women, and heavy drinkers to >2 glasses/d in men and >1 glass/d in women. Moreover, we utilized the alcohol-associated miRNAs to explore their potential mediatory role between alcohol consumption and liver-related traits. Finally, we retrieved putative target genes of identified miRNAs to gain an understanding of the molecular pathways concerning alcohol consumption., Results: Plasma concentrations of miR-193b-3p, miR-122-5p, miR-3937, and miR-4507 were significantly associated with alcohol consumption surpassing the Bonferroni-corrected P < 8.46 × 10-5. The top significant association was observed for miR-193b-3p (β = 0.087, P = 2.90 × 10-5). Furthermore, a potential mediatory role of miR-3937 and miR-122-5p was observed between alcohol consumption and liver traits. Pathway analysis of putative target genes revealed involvement in biological regulation and cellular processes., Conclusions: This study indicates that alcohol consumption is associated with plasma concentrations of 4 miRNAs. We outline a potential mediatory role of 2 alcohol-associated miRNAs (miR-3937 and miR-122-5p), laying the groundwork for further exploration of miRNAs as potential mediators between lifestyle factors and disease development., (© The Author(s) 2022. Published by Oxford University Press on behalf of the American Society for Nutrition.)
- Published
- 2023
- Full Text
- View/download PDF
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