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6 results on '"Karaali, Senay"'

1. Parahydrogen‐Polarized [1‐13C]Pyruvate for Reliable and Fast Preclinical Metabolic Magnetic Resonance Imaging (Adv. Sci. 30/2023)

Author

Nagel, Luca, primary, Gierse, Martin, additional, Gottwald, Wolfgang, additional, Ahmadova, Zumrud, additional, Grashei, Martin, additional, Wolff, Pascal, additional, Josten, Felix, additional, Karaali, Senay, additional, Müller, Christoph A., additional, Lucas, Sebastian, additional, Scheuer, Jochen, additional, Müller, Christoph, additional, Blanchard, John, additional, Topping, Geoffrey J., additional, Wendlinger, Andre, additional, Setzer, Nadine, additional, Sühnel, Sandra, additional, Handwerker, Jonas, additional, Vassiliou, Christophoros, additional, van Heijster, Frits H.A., additional, Knecht, Stephan, additional, Keim, Michael, additional, Schilling, Franz, additional, and Schwartz, Ilai, additional

Published
2023
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2. Parahydrogen-Polarized [1-13C]Pyruvate For Reliable and Fast Preclinical Metabolic Magnetic Resonance Imaging

Author

Nagel, Luca, primary, Gierse, Martin, additional, Gottwald, Wolfgang, additional, Ahmadova, Zumrud, additional, Grashei, Martin, additional, Wolff, Pascal, additional, Josten, Felix, additional, Karaali, Senay, additional, Müller, Christoph A., additional, Lucas, Sebastian, additional, Scheuer, Jochen, additional, Müller, Christoph, additional, Blanchard, John, additional, Topping, Geoffrey J., additional, Wendlinger, Andre, additional, Setzer, Nadine, additional, Sühnel, Sandra, additional, Handwerker, Jonas, additional, Vassiliou, Christophoros, additional, van Heijster, Frits H. A., additional, Knecht, Stephan, additional, Keim, Michael, additional, Schilling, Franz, additional, and Schwartz, Ilai, additional

Published
2023
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3. Parahydrogen-Polarized Fumarate for Preclinical in Vivo Metabolic Magnetic Resonance Imaging

Author

Gierse, Martin, primary, Nagel, Luca, additional, Keim, Michael, additional, Lucas, Sebastian, additional, Speidel, Tobias, additional, Lobmeyer, Tobias, additional, Winter, Gordon, additional, Josten, Felix, additional, Karaali, Senay, additional, Fellermann, Maximilian, additional, Scheuer, Jochen, additional, Müller, Christoph, additional, van Heijster, Frits, additional, Skinner, Jason, additional, Löffler, Jessica, additional, Parker, Anna, additional, Handwerker, Jonas, additional, Marshall, Alastair, additional, Salhov, Alon, additional, El-Kassem, Bilal, additional, Vassiliou, Christophoros, additional, Blanchard, John W., additional, Picazo-Frutos, Román, additional, Eills, James, additional, Barth, Holger, additional, Jelezko, Fedor, additional, Rasche, Volker, additional, Schilling, Franz, additional, Schwartz, Ilai, additional, and Knecht, Stephan, additional

Published
2023
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4. Parahydrogen‐Polarized [1‐13C]Pyruvate for Reliable and Fast Preclinical Metabolic Magnetic Resonance Imaging.

Author

Nagel, Luca, Gierse, Martin, Gottwald, Wolfgang, Ahmadova, Zumrud, Grashei, Martin, Wolff, Pascal, Josten, Felix, Karaali, Senay, Müller, Christoph A., Lucas, Sebastian, Scheuer, Jochen, Müller, Christoph, Blanchard, John, Topping, Geoffrey J., Wendlinger, Andre, Setzer, Nadine, Sühnel, Sandra, Handwerker, Jonas, Vassiliou, Christophoros, and van Heijster, Frits H.A.

Subjects
MAGNETIC resonance imaging, PYRUVATES, POLARIZATION (Nuclear physics), NUCLEAR spin, SPIN polarization, POLARIZERS (Light)
Abstract

Hyperpolarization techniques increase nuclear spin polarization by more than four orders of magnitude, enabling metabolic MRI. Even though hyperpolarization has shown clear value in clinical studies, the complexity, cost and slowness of current equipment limits its widespread use. Here, a polarization procedure of [1‐13C]pyruvate based on parahydrogen‐induced polarization by side‐arm hydrogenation (PHIP‐SAH) in an automated polarizer is demonstrated. It is benchmarked in a study with 48 animals against a commercial dissolution dynamic nuclear polarization (d‐DNP) device. Purified, concentrated (≈70–160 mM) and highly hyperpolarized (≈18%) solutions of pyruvate are obtained at physiological pH for volumes up to 2 mL within 85 s in an automated process. The safety profile, image quality, as well as the quantitative perfusion and lactate‐to‐pyruvate ratios, are equivalent for PHIP and d‐DNP, rendering PHIP a viable alternative to established hyperpolarization techniques. [ABSTRACT FROM AUTHOR]

Published
2023
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5. Parahydrogen-Polarized Fumarate for Preclinical in VivoMetabolic Magnetic Resonance Imaging

Author

Gierse, Martin, Nagel, Luca, Keim, Michael, Lucas, Sebastian, Speidel, Tobias, Lobmeyer, Tobias, Winter, Gordon, Josten, Felix, Karaali, Senay, Fellermann, Maximilian, Scheuer, Jochen, Müller, Christoph, van Heijster, Frits, Skinner, Jason, Löffler, Jessica, Parker, Anna, Handwerker, Jonas, Marshall, Alastair, Salhov, Alon, El-Kassem, Bilal, Vassiliou, Christophoros, Blanchard, John W., Picazo-Frutos, Román, Eills, James, Barth, Holger, Jelezko, Fedor, Rasche, Volker, Schilling, Franz, Schwartz, Ilai, and Knecht, Stephan

Abstract

We present a versatile method for the preparation of hyperpolarized [1-13C]fumarate as a contrast agent for preclinical in vivoMRI, using parahydrogen-induced polarization (PHIP). To benchmark this process, we compared a prototype PHIP polarizer to a state-of-the-art dissolution dynamic nuclear polarization (d-DNP) system. We found comparable polarization, volume, and concentration levels of the prepared solutions, while the preparation effort is significantly lower for the PHIP process, which can provide a preclinical dose every 10 min, opposed to around 90 min for d-DNP systems. With our approach, a 100 mM [1-13C]-fumarate solution of volumes up to 3 mL with 13–20% 13C-hyperpolarization after purification can be produced. The purified solution has a physiological pH, while the catalyst, the reaction side products, and the precursor material concentrations are reduced to nontoxic levels, as confirmed in a panel of cytotoxicity studies. The in vivousage of the hyperpolarized fumarate as a perfusion agent in healthy mice and the metabolic conversion of fumarate to malate in tumor-bearing mice developing regions with necrotic cell death is demonstrated. Furthermore, we present a one-step synthesis to produce the 13C-labeled precursor for the hydrogenation reaction with high yield, starting from 13CO2as a cost-effective source for 13C-labeled compounds.

Published
2023
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6. Parahydrogen-Polarized [1- 13 C]Pyruvate for Reliable and Fast Preclinical Metabolic Magnetic Resonance Imaging.

Author

Nagel L, Gierse M, Gottwald W, Ahmadova Z, Grashei M, Wolff P, Josten F, Karaali S, Müller CA, Lucas S, Scheuer J, Müller C, Blanchard J, Topping GJ, Wendlinger A, Setzer N, Sühnel S, Handwerker J, Vassiliou C, van Heijster FHA, Knecht S, Keim M, Schilling F, and Schwartz I

Subjects
Animals, Carbon Isotopes, Magnetic Resonance Imaging methods, Hydrogenation, Pyruvic Acid metabolism, Hydrogen
Abstract

Hyperpolarization techniques increase nuclear spin polarization by more than four orders of magnitude, enabling metabolic MRI. Even though hyperpolarization has shown clear value in clinical studies, the complexity, cost and slowness of current equipment limits its widespread use. Here, a polarization procedure of [1- 13 C]pyruvate based on parahydrogen-induced polarization by side-arm hydrogenation (PHIP-SAH) in an automated polarizer is demonstrated. It is benchmarked in a study with 48 animals against a commercial dissolution dynamic nuclear polarization (d-DNP) device. Purified, concentrated (≈70-160 mM) and highly hyperpolarized (≈18%) solutions of pyruvate are obtained at physiological pH for volumes up to 2 mL within 85 s in an automated process. The safety profile, image quality, as well as the quantitative perfusion and lactate-to-pyruvate ratios, are equivalent for PHIP and d-DNP, rendering PHIP a viable alternative to established hyperpolarization techniques., (© 2023 The Authors. Advanced Science published by Wiley-VCH GmbH.)

Published
2023
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