30 results on '"Karaağaç, Kemal"'
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2. Transient Complete heart block in a patient with bicuspid aortic valve: A case report
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Arıcan Özlük, Özlem, Karaağaç, Kemal, Yağcıoğlu, Pınar, Kuzeytemiz, Mustafa, Şentürk, Muhammed, Peker, Tezcan, Yılmaz, Mustafa, and Bursa Postgraduate Hospital, Department of Cardiology
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congenital, hereditary, and neonatal diseases and abnormalities ,Bicuspid aortic valve ,atrioventriculer block ,aortic aneurysm ,cardiovascular system ,cardiovascular diseases ,Bicuspid Aortic Valve ,Biküspit aortik kapak ,atriyoventriküler blok ,aort anevrizması ,Atrioventriculer Block ,Aortic Aneurysm - Abstract
Bicuspid aortic valve is a common congenital cardiovascular malformation. We present a case with bicuspid aorta and ascending aortic aneurysm developing transient complete heart block. This case is the first in literature to report the concurrence of bicuspid aortic valve and ascending aortic dilatation with transient complete heart block, Biküspit aort kapak sık görülen doğumsal kardiyovasküler bozukluktur. Sunduğumuz vaka biküspit aort kapak ve çıkan aort anevrizmasında gelişen geçici tam kalp bloğudur. Bu vaka biküspit aort ve çıkan aort genişlemesine geçici kalp bloğunun eşlik ettiği literatürdeki ilk vakadır
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- 2015
3. ST Elevasyonsuz Miyokard İnfarktüslü Hastada Sağ Koroner Ostiumun'dan Kaynaklanan İzole Tek Koroner Arter
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KARAAĞAÇ, Kemal, ÖZLÜK, Özlem ARICAN, YILMAZ, Mustafa, ASLAN, Burhan, and TOPAL, Dursun
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Coronary vessel anomalies ,coronary artery disease ,myocardial infarction ,Koroner damar anomalileri,koroner arter hastalığı,miyokard infarktüsü - Abstract
Single coronary artery is a rare congenital anomaly. In case of left main artery traveling between aorta and pulmonary artery sudden death can be occurred, although this does not usually effect coronary flow. We present a 63-year-old woman whose coronary angiography for typical chest pain revealed an isolated single coronary artery. On coronary angiography, the whole coronary system originated by a single trunk from the right sinus of Valsalva. A significant flow-limiting lesion was found in the right coronary artery that was successfully treated with percutaneous coronary intervention, Tek koroner arter, oldukça nadir rastlanan konjenital bir anomalidir. Genellikle koroner kan akımını etkilememekle birlikte sol ana koroner arterin aort ile pulmoner arter arasında seyrettiği durumlarda ani ölüm görülebilir. Biz tipik göğüs ağrısı nedeniyle koroner anjiyografi yapılan 63 yaşındaki bayan hastada ortaya çıkan izole tek koroner arteri sunduk. Koroner angiografide, tüm koroner sistem tek gövde halinde sağ sinüs valsalvadan çıkıyordu. Sağ koroner arterde tesbit edilen akımı kısıtlayan önemli darlık perkütan koroner girişimle başarılı bir şekilde tedavi edildi
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- 2015
4. Tekrarlayan Anjinaya Neden Olduğu Düşünülen LIMA Yan Dalının Başarılı Koil Embolizasyonu
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BEKLER, Adem, KARAAĞAÇ, Kemal, PEKER, Tezcan, ÖZLÜK, Özlem ARICAN, YILMAZ, Mustafa, KUZEYTEMİZ, Mustafa, and VATANSEVER, Fahriye
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fluids and secretions ,surgical procedures, operative ,parasitic diseases ,population characteristics ,Coronary artery bypass ,angina ,coil embolization ,Koroner arter baypas ,anjina ,koil embolizasyon ,geographic locations - Abstract
The left internal mammarian artery (LIMA) is the most commonly used arterial graft for coronary artery bypass grafting (CABG). Selective occlusion of LIMA side branches during surgery is important for avoiding myocardial ischemia. We report on a case with limp claudication on exertion due to patent LIMA side branch following CABG operation two years prior to hospital admission. The patent side branch was successfully occluded with coil embolization, Koroner arter baypas cerrahisinde greft amacıyla sık kullanılan sol internal mamaryan arterde (LIMA) yan dalların anastomoz öncesi kapatılması, cerrahi sonrası çalmaya bağlı miyokard iskemisini engellemek için son derece önemlidir. Bu vakada koroner arter baypas cerrahisinden 2 yıl sonra özellikle kol egzersizi sırasında belirginleşen göğüs ağrısı yakınması bulunan bir hastada koroner çalma sendromuna neden olduğunu düşündüğümüz LIMA yan dalı başarılı koil embolizasyon ile kapatılmasını gösterdik
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- 2015
5. Successful coil embolization of LIMA side branch that is suspected to cause recurrent angina
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Bekler, Adem, Karaağaç, Kemal, Peker, Tezcan, Arıcan Özlük, Özlem, Yılmaz, Mustafa, Kuzeytemiz, Mustafa, Vatansever, Fahriye, Bursa Yüksek İhtisas Eğitim ve Araştırma Hastanesi, and Bursa Esentepe Medikal Hastanesi
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Koil Embolizasyon ,Koroner Arter Baypas ,Anjina - Abstract
Koroner arter baypas cerrahisinde greft amacıyla sık kullanı- lan sol internal mamaryan arterde (LIMA) yan dalların anastomoz öncesi kapatılması, cerrahi sonrası çalmaya bağlı miyokard iskemisini engellemek için son derece önemlidir. Bu vakada koroner arter baypas cerrahisinden 2 yıl sonra özellikle kol egzersizi sırasında belirginleşen göğüs ağrısı yakınması bulunan bir hastada koroner çalma sendromuna neden olduğunu düşündüğümüz LIMA yan dalı başarılı koil embolizasyon ile kapatılmasını gösterdik. The left internal mammarian artery (LIMA) is the most commonly used arterial graft for coronary artery bypass grafting (CABG). Selective occlusion of LIMA side branches during surgery is important for avoiding myocardial ischemia. We report on a case with limp claudication on exertion due to patent LIMA side branch following CABG operation two years prior to hospital admission. The patent side branch was successfully occluded with coil embolization.
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- 2014
6. FIRST YEAR EXPERIENCE OF A NEW ESTABLISHED ELECTROPHYSIOLOGY LABORATORY
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YONTAR, Osman Can, TENEKECİOĞLU, Erhan, KARAAĞAÇ, Kemal, TÜTÜNCÜ, Ahmet, and MELEK, Mehmet
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Aritmi,Elektrofizyoloji ,Arrhythmia,Electrophysiology - Abstract
AMAÇ: Aritmiler, kardiyolojiyi ilgilendiren hastalık grubu içinde önemli yer tutarlar. Aritmi hastalarının tanı ve tedavisinde seçkin bir tedavi metodu olan elektrofizyolojik çalışma ve ablasyon; özel ilgi, zaman ve eğitim gerektiren bir yaklaşımdır. Merkezimizde yeni kurulan laboratuvarımızın ilk yıl kabul ettiği hasta profilini, yapılan işlemleri, başarı oranlarını, komplikasyonları ve nüksleri incelemeyi amaçladık. YÖNTEMLER: Bursa Yüksek İhtisas Eğitim ve Araştırma Hastanesi hasta kayıtları geriye dönük olarak incelendi. Ocak 2013’te kurulan elektrofizyoloji laboratuvarına, Ocak 2014’e kadar kabul edilen hastalar tespit edildi. Hastaların yaşları, cinsiyetleri, elektrofizyolojik çalışma sonrası tanıları, eşlik eden hastalıkları, yapılan işlem, poliklinik takip verileri, işlemin kısa ve orta vade başarısı, nüks oranı ve komplikasyonlar tarandı. BULGULAR: Geriye dönük olarak taranan toplam hasta sayısı 131, toplam işlem sayısı ise mükerrer işlemler dahil olmak üzere 231 idi. İşlemlerin %59 tanısal, %41 ise tedavi edici amaçla yapılmıştı. Tanısal işlemlerin sonucunda % 80 (n=100) supraventriküler taşikardi, %5,2 (n=7) normal bulgular, %6,7 (n=9) ventriküler taşikardi, %11,1 (n=15) AV ve/veya SA nod hastalığı tanıları konulmuştu. SONUÇ: Merkezimizde elektrofizyoloji laboratuvarının kurulması sonrasındaki ilk yıl verileri ümit vericidir. Merkezimizde 2013 yılında işlem/iş günü oranı 0,91 idi. Bu oran, neredeyse her çalışma gününe bir işlem (tanısal ya da tedavi edici) anlamına geliyordu. Ablasyon/iş günü oranı ise 0,37 olup, her üç iş gününden bir tanesinde ablasyon yapıldığı (basit ya da ileri düzey farkı gözetmeksizin) olarak yorumlandı. Ekibin uyumu ve operatör sayısının artmasıyla, EFÇ için ayırılan sürenin artışıyla ilerleyen yıllarda kompleks işlem sayısının artacağını düşünüyoruz., OBJECTIVE: One of the most frequent diagnosis in whole group of cardiologic diseases are arrhythmias. Electrophysiological study and ablation, which are elite methods for diagnosis and treatment of arrhythmias, require special interest and training. Our aim is to investigate the patient profile, interventions, success rates, complications and recurrences of our newly established laboratory in first year. METHODS: Retrospectively analysis of Bursa Ihtisas Training and Research Hospital were done. All cases who undervent electrophysiological study and ablation were detected. All patient demographic and procedural data were collected. RESULTS: A total of 131 patients and 231 procedures, including diagnostic and therapeutic and re-do cases, were examined. Fifty-nine percent of all casese were diagnostic, remaining 41 % were therapeutic. Diagnosis of all cases were: 80% (n=100) supraventricular tachicardia, 5.2% (n=7) normal findings, 6.7% (n=9) were ventricular tachicardia, 11.1% (n=15) were AV and/or SA nod disease. CONCLUSION: First year experience of our newly established laboratory are hopeful. In our center, procedure to working day ratio was 0.91, meaning one procedure daily. Ablation to working day ratio was 0.37, meaning one therapeutic procedure every three days, without excluding complex procedures. In our opinion, development of team-work and harmony, and also incerase in operator number would lead to an increase in amount of complex procedures.
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- 2014
7. Olanzapıne Usage Prolongs T Wave Peak To T Wave End Segment In Patıents Wıth Normal QT Interval
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YONTAR, Osman Can, YONTAR, Gözde, TÜTÜNCÜ, Ahmet, KARAAĞAÇ, Kemal, TENEKECİOĞLU, Erhan, KARAKUŞ, Alper, and MELEK, Mehmet
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Tp-e,arrhythmia,olanza ,Tp-e,aritmi,olanzapin - Abstract
Amaç: Antipsikotik ilaçların QT intervalini uzatarak ani kardiyak ölüme yol açabildikleri uzun süredirbilinmektedir. İkinci nesil antipsikotikler, düşük aritmik etkileri nedeniyle birinci nesilden daha güvenliolarak değerlendirilmektedir. Olanzapin en sık kullanılan ikinci nesil antipsikotiklerden birisidir ancak QTintervaline olan etkisi için çelişkili veriler mevcuttur. Yapılan çalışmalar, 12-kanal elektrokardiyogramda Tdalga tepe noktasından sonlanım noktasına kadar ölçülen intervalin (Tp-e) uzamasının ventriküleraritmogenezin belirteci olduğunu göstermektedir. Çalışmamızın amacı, olanzapin tedavisi altındakihastaların ventriküler repolarizasyon anormalliklerini Tp-e, Qt ve QTc intervalleri ve Tp-e/QT oranıkullanarak değerlendirmektir.Materyal ve Metot: Hasta kayıtları retrospektif olarak incelendi. En az 3 aydır olanzapin kullanmakta olanşizofreni hastalarının EKG'leri incelendi.Yaş ve cinsiyet uyumlu kontrol grubu da karşılaştırma için grubadahil edildi. Yüzeyel EKG'lerin dijital ortamda bilgisayar programıyla QT, QTc ve Tp-e intervalleri ölçüldü.Bulgular: Her iki grubun demografik özellikleri benzerdi. Hastaların kullandığı Ortalama günlük olanzapindozu 20,3±7 mg idi. Her iki grup QT (371,8±55,4 vs. 362,61±34,7; p=0,440) ve QTc (455,98±49,3 vs.434,48±43,724; p=0,077) intervalleri açısından farksızdı. Ancak Tp-e intervali olanzapin kullananhastalarda anlamlı olarak uzamış bulundu (89,5±31,8 vs. 76,4±9,8; p=0,039).Sonuç: T dalgası tepe noktası-sonlanım noktası intervali, sol ventrikül transmural repolarizasyondispersiyonunun göstergesi ve ventriküler aritmogenez belirteci olarak kabul edilmektedir. Tp-e/QT isedaha yeni bir parametre olup aynı defektlere işaret etmektedir. Bulgularımız, yalnızca olanzapin tedavisialan hastalarda sağlıklı bireylere göre uzamış Tp-e intervali ve daha yüksek Tp-e/QT (p=0,041)göstermiştir. Antipsikotikler QT intervalini uzatmayabilir, ancak sadece Tp-e segmentindeki uzama darepolarizasyon heterojenitesine işaret edebilir. Tp-e ve Tp-e/QT ölçümlerinin antipsikotik olanzapin kullanan hastalarda ventriküler aritmi riskinin belirteci olabileceğini düşünüyoruz., Background: Antipsychotic drugs are long known to cause prolongation in QTinterval which is a marker ofincreased risk for sudden cardiac death. Studies indicate that prolongation of the interval between the peakand end of the T wave (Tpeak to Tend, Tp-e) on the 12-lead ECG, is a marker of ventriculararrhythmogenesis. The aim of this study was to assess ventricular repolarization in patients who are onantipsychotic therapy by using Tp-e, QTand QTc interval and Tp-e/QTratio.Material and Method: Patient records were retrospectively analyzed. Electrocardiogram of 31 patients,who were on antipsychotic drug therapy (olanzapine) at least 3 months, were obtained and scanned. T wavepeak to end interval, QT and corrected QT (QTc) intervals and some other ECG intervals were measured.Electrocardiograms of age and sex matched 31 healthy control individuals were also analyzed forcomparison. Patients with critical coronary stenosis, moderate or severe valve disease, left and/or right heartfailure, left and/or right ventricle hypertrophy, atrial fibrillation, right or left bundle block or patients who gotpacemaker or ICD implanted were excluded.Results: Both groups' baseline characteristics were similar. Mean olanzapine dose for patients was 20,3±7mg. Both groups did not differ in QT (371,8±55,4 vs. 362,61±34,7; p=0,440) and QTc (455,98±49,3 vs.434,48±43,724; p=0,077) interval measurements. However, patients who were on olanzapine hadsignificantly longer Tp-e (89,5±31,8 vs. 76,4±9,8; p=0,039) than controls.Discussion: T wave peak to end interval is a measure of transmural dispersion of repolarization in the leftventricle and accepted as a surrogate for increased ventricular arrhythmogenesis risk. Tp-e/QTis a relativelynew marker which also indicates repolarization defects. Antipsychotic drugs are claimed to be responsiblefor QT prolongation and increase risk for Torsades de pointes. Our findings show that patients who are onolanzapine treatment alone, have significantly longer Tp-e and higher Tp-e/QT(0,23 vs. 0,21; p=0,041) thanhealthy controls. Antipsychotics may not prolong QT interval, however; may cause repolarizationheterogeneity and lengthen the Tp-e segment of whole QT interval. Tp-e and Tp-e/QT are suggestivesurrogates of ventricular arrhythmogenesis risk in patients who are on antipsychotic drugs. 
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- 2014
8. Koroner angiografi işlemi esnasında tesadüfen saptanan ciddi aort koarktasyonu
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KARAAĞAÇ, Kemal, ÖZLÜK, Özlem Arican, YILMAZ, Mustafa, ASLAN, Burhan, TOPAL, Dursun, KUZEYTEMİZ, Mustafa, ŞENTÜRK, Muhammed, TOKTAŞ, Faruk, and Bursa Postgraduate Hospital
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Aortic coarctation ,hypertension ,unstable angina pectoris ,Hypertension ,cardiovascular system ,Unstable Angina Pectoris ,Aort koarktasyonu ,hipertansiyon ,kararsız angina pektoris ,Aortic Coarctation - Abstract
Konjenital kalp hastalıkları içerisinde % 5-8 oranında sıklığa sahip aort koarktasyonuna biküspit aort kapağı sıklıkla eşlik etmektedir. Aort koarktasyonu tipik olarak çocukluk ve erken erişkin döneminin hastalığıdır ve onarım yapılmazsa yaşam süresi azalır. Onarım yapılmayan hastalarda ölüm; sıklıkla kalp yetersizliği, koroner arter hastalığı, aort rüptürü/ diseksiyonu, enfektif endokardit/ endarterit veya serebral hemorajiye bağlıdır. Bu yazıda, 60 yaşında çıkan aort anevrizması, aort koarktasyonu ve biküspid aort kapağı olan kararsız angina pektoris ile acil servise gelen hasta takdim edilmiştir, Aortic coarctation (AC) represents about 5-8 % of all congenital cardiac diseases and a combination with other bicuspid aortic valve is commonly seen. AC is typically a disease of childhood and early adulthood, reducing life expectancy in patients who have not undergone correction. Death in patients who do not undergo repair is usually due to heart failure, coronary artery disease, aortic rupture/ dissection, infective endocarditis/ endarteritis or cerebral hemorrhage. In this report, a 60-year-old patient administered to our emergency department due to unstable angina pectoris with asymptomatic aneurysm of the ascending aorta, AC and a bicuspid aortic valve is presented
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- 2014
9. Myocardial performance index in patients with coronary slow flow
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BEKLER, Adem, KARAAĞAÇ, Kemal, ÖZLÜK, Özlem Arican, VATANSEVER, Fahriye, ŞENTÜRK, Muhammed, KUZEYTEMİZ, Mustafa, YILMAZ, Mustafa, and Bursa Yuksek Ihtisas Training and Research Hospital
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Echocardiography ,Coronary Circulation ,Ventriculer function ,coronary circulation ,echocardiography ,Ventriküler fonksiyon ,koroner dolaşım ,ekokardiyografi ,Ventriculer Function - Abstract
Objective: This study was aimed to investigate the left ventriculer myocardial performance index (Tei index) in patients with coronary slow flow phenomenon Material and Methods: 25 patients with slow coronary flow (15 men; 10 women; mean age 51 ± 12 years) and 20 subjects with angiographically normal coronary arteries (12 men; 8 women; mean age 52 ± 12 years) were included in the study. All the subjects underwent echocardiography and tissue Doppler imaging to determine left ventriculer (LV) diastolic functions and left ventriculer myocardial performance index (LV MPI). Results: Conventional echocardiography parameters, maximal velocity of early diastolic filling (p=0,02), ratio of maximal early to late diastolic filling (p=0,037) were significantly lower, deceleration time of early diastolic filling was significantly higher (p=0,043) in the patient group. Among tissue Doppler parameters the mitral annulus peak early diastolic velocity and ratio of early to late diastolic velocity were lower in patients group than in controls (p, Amaç: Bu çalışmada koroner yavaş akımı olan hastalarda sol ventrikül miyokard performans indeksinin (Tei indeksi) incelenmesi amaçlanmıştır. Gereç ve Yöntem: Koroner yavaş akımı olan 25 hasta (15 erkek; 10 kadın; ort yaş 51 ± 12 yıl) ve koroner arterleri normal olan 20 olgu (12 erkek; 8 kadın; ort yaş 52 ± 12 yıl) çalışmaya alınmıştır. Tüm hastaların ekokardiyografi ve doku doppler görüntüleme ile sol ventrikül diyastolik fonksiyonları ve miyokard performans indeksi saptandı. Bulgular: Koroner yavaş akımı olan grupta maksimal erken diyastolik dolum hızı, maksimal erken diyastolik dolum hızının geç diyastolik akım hızına oranı (p=0,037) anlamlı derecede düşük saptanırken; erken diyastolik dolum hızı deselerasyon zamanı anlamlı derecede yüksekdi (p=0,043). Hasta grubunda, kontrol grubuna göre doku doppler parametreleri arasında mitral anulus erken pik diyastolik hız ve erken diyastolik akım oranı anlamlı derecede düşük saptandı (p
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- 2014
10. Tekrarlayan anjinaya neden olduğu düşünülen lıma yan dalının başarılı koil embolizasyonu
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Bekler, Adem, Karaağaç, Kemal, Peker, Tezcan, Arıcan Özlük, Özlem, Yılmaz, Mustafa, Kuzeytemiz, Mustafa, and Vatansever, Fahriye
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Kalp ve Kalp Damar Sistemi - Abstract
Koroner arter baypas cerrahisinde greft amacıyla sık kullanılan sol internal mamaryan arterde (LIMA) yan dalların anastomoz öncesi kapatılması, cerrahi sonrası çalmaya bağlı miyokard iskemisini engellemek için son derece önemlidir. Bu vakada koroner arter baypas cerrahisinden 2 yıl sonra özellikle kol egzersizi sırasında belirginleşen göğüs ağrısı yakınması bulunan bir hastada koroner çalma sendromuna neden olduğunu düşündüğümüz LIMA yan dalı başarılı koil embolizasyon ile kapatılmasını gösterdik. The left internal mammarian artery (LIMA) is the most commonly used arterial graft for coronary artery bypass grafting (CABG). Selective occlusion of LIMA side branches during surgery is important for avoiding myocardial ischemia. We report on a case with limp claudication on exertion due to patent LIMA side branch following CABG operation two years prior to hospital admission. The patent side branch was successfully occluded with coil embolization.
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- 2014
11. Koroner arter hastalığı saptanan hastalarda pfa-100 sistemi ile aspirin direnci sıklığının araştırılması
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Karaağaç, Kemal, Güllülü, Sümeyye, Şentürk, Tunay, Karaağaç, Esra, Sarandöl, Emre, and Aydınlar, Ali
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Acil Tıp ,Kalp ve Kalp Damar Sistemi ,Tıbbi Araştırmalar Deneysel ,Anestezi ,Genel ve Dahili Tıp ,Periferik Damar Hastalıkları - Abstract
Amaç: Aspirin günümüzde en yaygın kullanılan antitrombotik ilaçtır. Çalışmamızda koroner arter hastalığı (KAH) saptanan olgularda PFA-100 sistemiyle aspirin diren- cinin (AD) sıklığı değerlendirildi. Gereç ve Yöntem: Çalışmamıza en az 4 hafta süre ile düzenli olarak, 100 mg ve daha fazla Aspirin kullanan koroner anji- yografisi yapılan 97 hasta dahil edildi. Hastalarda PFA-100 sistemi kullanılarak AD saptandı. Bulgular: Tüm olgularımız aspirine yanıt bakımından karşı- laştırıldığında KAH saptananlarda, saptanmayanlara göre AD anlamlı derecede yüksek bulundu. KAH saptanan aspirine dirençli grupta, sigara içiciliği daha fazlaydı, LDL değerleri ve Total Kolesterol/HDL değerleri aspirine duyarlı gruba göre anlamlı derecede yüksekti. KAH saptananlarda AD olanlar kullandıkları aspirin dozu (100mg ve 300mg) açısından karşılaştırıldıklarında iki grup arasında istatistiksel açıdan anlamlı bir fark saptanmamıştır. KAH saptanan olgular tek damar hastalığı olanlar grup 1 (n=21, % 35), iki damar hasta- lığı olanlar grup 2 (n=16, % 26) ve üç damar hastalığı olanlar grup 3 (n=23, % 38) olmak üzere üç gruba ayrıldı. Üç hasta grubu AD açısından karşılaştırıldıklarında istatistiksel olarak anlamlı farklılık saptanmamıştır. Sonuç: Aspirin tedavisi alan hastalarda cevabın benzer olmadığı gösterildi. KAH saptanan olgularda aspirin cevabı- nın yeterliliğinin her hastada PFA-100 sistemi ile kısa sürede değerlendirilip tedavinin bu sonuçlara göre düzenlenebile- ceği kanaatine varıldı. Objective: Today aspirin is the most widely used antithrombotic drug. In this study frequency of the aspirin resistance (AR) was evaluated in coronary artery disease (CAD) patients with PFA-100 system. Material and Methods: In the study 97 patients that routinely used 100 mg or higher aspirin for four weeks and that had coronary angiographic examination were included. In the cases with PFA-100 system AR was determined. Results: When all the cases were examined for AR, it was more frequent in the cases with CAD. In the group with CAD, patients with AR more frequently smoked smoking and the LDL and Total Cholesterol/HDL cholesterol levels were significantly higher compared to the aspirin sensitive patients. When the cases with CAD were compared according to the aspirin dose they had (100mg ve 300mg) the two groups did not differ significantly. The patients with CAD were divided into three goups accordıng to the number of dıseased vessels. Group 1 was constituted of cases with one vessel disease (n=21, % 35), group 2 two vessel disease (n=16, % 26) and group 3 was constituted of patients with three vessel disease (n=23, % 38). There no was statistically significant difference in terms of AR among all three groups. Conclusion: As a result, it was shown that the responses were not the same in patients taking aspirin. It was concluded that in cases with CAD adequacy of aspirin response may be quickly evaluated by PFA-100 system and the therapy may be adjusted according to the results
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- 2014
12. Investigation of aspirin resistance of frequency in patients with coronary artery disease by using pfa-100 system
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Karaağaç, Kemal, Güllülü, Sümeyye, Şentürk, Tunay, Karaağaç, Esra, Sarandöl, Emre, Aydınlar, Ali, and Uludağ Üniversitesi, Tıp Fakültesi
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Koroner Arter Hastalığı ,PFA-100 Sistemi ,Aspirin Direnci - Abstract
Amaç: Aspirin günümüzde en yaygın kullanılan antitrombotik ilaçtır. Çalışmamızda koroner arter hastalığı (KAH) saptanan olgularda PFA-100 sistemiyle aspirin direncinin (AD) sıklığı değerlendirildi. Gereç ve Yöntem: Çalışmamıza en az 4 hafta süre ile düzenli olarak, 100 mg ve daha fazla Aspirin kullanan koroner anjiyografisi yapılan 97 hasta dahil edildi. Hastalarda PFA-100 sistemi kullanılarak AD saptandı. Bulgular: Tüm olgularımız aspirine yanıt bakımından karşı- laştırıldığında KAH saptananlarda, saptanmayanlara göre AD anlamlı derecede yüksek bulundu. KAH saptanan aspirine dirençli grupta, sigara içiciliği daha fazlaydı, LDL değerleri ve Total Kolesterol/HDL değerleri aspirine duyarlı gruba göre anlamlı derecede yüksekti. KAH saptananlarda AD olanlar kullandıkları aspirin dozu (100mg ve 300mg) açısından karşılaştırıldıklarında iki grup arasında istatistiksel açıdan anlamlı bir fark saptanmamıştır. KAH saptanan olgular tek damar hastalığı olanlar grup 1 (n=21, % 35), iki damar hastalığı olanlar grup 2 (n=16, % 26) ve üç damar hastalığı olanlar grup 3 (n=23, % 38) olmak üzere üç gruba ayrıldı. Üç hasta grubu AD açısından karşılaştırıldıklarında istatistiksel olarak anlamlı farklılık saptanmamıştır. Sonuç: Aspirin tedavisi alan hastalarda cevabın benzer olmadığı gösterildi. KAH saptanan olgularda aspirin cevabı- nın yeterliliğinin her hastada PFA-100 sistemi ile kısa sürede değerlendirilip tedavinin bu sonuçlara göre düzenlenebileceği kanaatine varıldı. Objective: Today aspirin is the most widely used antithrombotic drug. In this study frequency of the aspirin resistance (AR) was evaluated in coronary artery disease (CAD) patients with PFA-100 system. Material and Methods: In the study 97 patients that routinely used 100 mg or higher aspirin for four weeks and that had coronary angiographic examination were included. In the cases with PFA-100 system AR was determined. Results: When all the cases were examined for AR, it was more frequent in the cases with CAD. In the group with CAD, patients with AR more frequently smoked smoking and the LDL and Total Cholesterol/HDL cholesterol levels were significantly higher compared to the aspirin sensitive patients. When the cases with CAD were compared according to the aspirin dose they had (100mg ve 300mg) the two groups did not differ significantly. The patients with CAD were divided into three goups accordıng to the number of dıseased vessels. Group 1 was constituted of cases with one vessel disease (n=21, % 35), group 2 two vessel disease (n=16, % 26) and group 3 was constituted of patients with three vessel disease (n=23, % 38). There no was statistically significant difference in terms of AR among all three groups. Conclusion: As a result, it was shown that the responses were not the same in patients taking aspirin. It was concluded that in cases with CAD adequacy of aspirin response may be quickly evaluated by PFA-100 system and the therapy may be adjusted according to the results
- Published
- 2014
13. Masif Dil Hematomu: Trombolitik Tedavinin Nadir Bir Komplikasyonu
- Author
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BEKLER, Adem, primary, KARAAĞAÇ, Kemal, additional, VATANSEVER, Fahriye, additional, Arıcan ÖZLÜK, Özlem, additional, YILMAZ, Mustafa, additional, KUZEYTEMİZ, Mustafa, additional, and PEKER, Tezcan, additional
- Published
- 2016
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14. Tp-Te Interval and Tp-Te/QT Ratio in Polycystic Ovary Syndrome
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Karaağaç, Kemal, primary
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- 2016
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15. St elevasyonsuz miyokard infarktüslü hastada sağ koroner ostiumun’dan kaynaklanan izole tek koroner arter
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Karaağaç, Kemal, Arıcan Özlük, Özlem, Yılmaz, Mustafa, Aslan, Burhan, Topal, Dursun, and Bursa Yüksek İhtisas Eğitim ve Araştırma Hastanesi
- Subjects
Coronary Vessel Anomalies ,Myocardial İnfarction ,Coronary Artery Disease - Abstract
Single coronary artery is a rare congenital anomaly. In case of left main artery traveling between aorta and pulmonary artery sudden death can be occurred, although this does not usually effect coronary flow. We present a 63-year-old woman whose coronary angiography for typical chest pain revealed an isolated single coronary artery. On coronary angiography, the whole coronary system originated by a single trunk from the right sinus of Valsalva. A significant flow-limiting lesion was found in the right coronary artery that was successfully treated with percutaneous coronary intervention. Tek koroner arter, oldukça nadir rastlanan konjenital bir anomalidir. Genellikle koroner kan akımını etkilememekle birlikte sol ana koroner arterin aort ile pulmoner arter arasında seyrettiği durumlarda ani ölüm görülebilir. Biz tipik göğüs ağrısı nedeniyle koroner anjiyografi yapılan 63 yaşındaki bayan hastada ortaya çıkan izole tek koroner arteri sunduk. Koroner angiografide, tüm koroner sistem tek gövde halinde sağ sinüs valsalvadan çıkıyordu. Sağ koroner arterde tesbit edilen akımı kısıtlayan önemli darlık perkütan koroner girişimle başarılı bir şekilde tedavi edildi.
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- 2013
16. Right ventricular function and its relation with TIMI frame count in the coronary slow flow phenomenon
- Author
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YILMAZ, Mustafa, ÖZLÜK, Fatma Özlem ARICAN, PEKER, Tezcan, BEKLER, Adem, and KARAAĞAÇ, Kemal
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Genetics ,Genetic diversity ,media_common.quotation_subject ,Native Polyacrylamide Gel Electrophoresis ,General Medicine ,Key words: Right ventricle,coronary slow flow ,Biology ,Isozyme ,Esterase ,Speciation ,Evolutionary biology ,Polymorphism (computer science) ,Genetic variation ,cardiovascular system ,cardiovascular diseases ,Musca ,media_common - Abstract
To investigate right ventricular function using conventional and tissue Doppler echocardiography in patients with coronary slow flow. Materials and methods: Twenty-two patients with slow coronary flow and 22 healthy subjects were included in the study. Right ventricular function was evaluated by conventional and tissue Doppler echocardiography. Additionally, right ventricular global function was assessed by myocardial performance index. Results: The tricuspid annulus peak early diastolic velocity (11.4 ± 2.2 cm/s, 13.9 ± 3 cm/s) and ratio of early to late diastolic velocity (0.70 ± 0.17 cm/s, 1.2 ± 0.38 cm/s) were lower in the patient group than in the controls (P = 0.05, P = 0.002, respectively). Late diastolic velocity (16.4 ± 3 cm/s, 14.4 ± 3 cm/s) and isovolumetric relaxation time (80 ± 9 ms, 66 ± 4 ms) were significantly higher in the patient group than in the controls (P = 0.024, P < 0.001, respectively). Right ventricular myocardial performance index was significantly prolonged in the coronary slow flow group (0.51 ± 0.03, 0.40 ± 0.02, P < 0.001). TIMI frame count was negatively correlated with the tricuspid lateral annulus early diastolic velocity and the ratio of tricuspid lateral annulus early to late diastolic velocity, whereas it was positively correlated with tricuspid isovolumetric relaxation time and right ventricular myocardial performance index. Conclusion: Right ventricular diastolic dysfunction exists in patients with the coronary slow flow phenomenon and it is correlated with TIMI frame count.
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- 2013
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17. Isolated single coronary artery originating from a single right coronary ostium in a patient with non st-segment elevation myocardial infarction
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Karaağaç, Kemal, Arıcan Özlük, Özlem, Yılmaz, Mustafa, Aslan, Burhan, and Topal, Dursun
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Genel ve Dahili Tıp - Abstract
Tek koroner arter, oldukça nadir rastlanan konjenital bir anomalidir. Genellikle koroner kan akımını etkilememekle birlikte sol ana koroner arterin aort ile pulmoner arter arasında seyrettiği durumlarda ani ölüm görülebilir. Biz tipik göğüs ağrısı nedeniyle koroner anjiyografi yapılan 63 yaşındaki bayan hastada ortaya çıkan izole tek koroner arteri sunduk. Koroner angiografide, tüm koroner sistem tek gövde halinde sağ sinüs valsalvadan çıkıyordu. Sağ koroner arterde tesbit edilen akımı kısıtlayan önemli darlık perkütan koroner girişimle başarılı bir şekilde tedavi edildi. Single coronary artery is a rare congenital anomaly. In case of left main artery traveling between aorta and pulmonary artery sudden death can be occurred, although this does not usually effect coronary flow. We present a 63-year-old woman whose coronary angiography for typical chest pain revealed an isolated single coronary artery. On coronary angiography, the whole coronary system originated by a single trunk from the right sinus of Valsalva. A significant flow-limiting lesion was found in the right coronary artery that was successfully treated with percutaneous coronary intervention.
- Published
- 2013
18. First year experience of a new established electrophysiology laboratory
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Yontar, Osman Can, primary, Tenekecioğlu, Erhan, additional, Karaağaç, Kemal, additional, Tütüncü, Ahmet, additional, and Melek, Mehmet, additional
- Published
- 2015
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19. The Value of Tissue Doppler Imaging in Prediction of Multivessel Disease in Patients with Acute Inferior Myocardial Infarction Treated by Thrombolytic Therapy
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Geleri, Hikmet, primary, Yılmaz, Mustafa, additional, Karaağaç, Kemal, additional, Vatansever Ağca, Fahriye, additional, Tenekecioğu, Erhan, additional, Arıcan Özlük, Özlem, additional, Peker, Tezcan, additional, and Kuzeytemiz, Mustafa, additional
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- 2015
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20. Koroner arter hastalığı saptanan hastalarda PFA-100 sistemi ile aspirin direnci sıklığının araştırılması
- Author
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Karaağaç, Kemal, Güllülü, Sümeyye, and Kardiyoloji Ana Bilim Dalı
- Subjects
Kardiyoloji ,Cardiology - Abstract
Uludağ Üniversitesi Tıp Fakültesi Ortopedi ve Travmatoloji AnabilimDalı Ocak 1995-Aralık 2005 tarihleri arasında parmak tümörü ve tümörbenzeri lezyon nedeniyle ameliyat edilen 150 hasta çalışmaya dahil edildi.Tümoral lezyonların lokalizasyonu parmaktaki anatomik bölgelere göreyapıldı.Kemik dokusundan kaynaklanan tümörler yerleştiği falanksa göreproksimal (zon I), orta ( zon II) ve distal (zon III) yerleşimli olaraksınıflandırıldı.Başparmakta bu proksimal ( zon I ) ve distal (zon III ) olaraksınıflandırıldı.Yumuşak doku tümörlerinin yerleşiminde yine anatomik kriterler gözönünde bulundurularak parmaklar çeşitli zonlara ayrıldı.Metakarpo-falangeal eklem zon I'e dahil edildi, proksimal interfalangealeklem zon II'ye, distal interfalangial eklem ise zon III'e dahil edilmiştir.Başparmak farklı olarak sadece zon I'i ve zon III'ü içermektedir.Parmak cilt ve cilt altı anatomisinin dorsal ve volarda farklılıkgöstermesi göz önünde bulundurularak yumuşak doku tümörleri ayrıca dorsalve volar olarak da sınıflandırılmıştır.Sonuçta; çalışmada en sık görülen tümör benzeri lezyon sinovit veganglion oldu. En sık 3. parmak ve zon Ia `da saptandı.En sık benign yumuşak doku tümörü tendon kılıfı dev hücreli tümöroldu. Yoğunlukla 2. parmak zon I a ve zon II a'da saptandı.Kemik ve kıkırdak dokusu tümörlerinden en sık enkondrom veosteokondrom görüldü. En sık erkeklerde, sağ elde ve zon I'de görüldü.Olguların çoğu kadındı.Tümörler en sık sağ elde ve işaret parmağında saptandı.Anahtar kelimeler: parmak, tümör lokalizasyonu, tümörsınıflandırması.4 Today aspirin is the most widely used antithrombotic drug. Occuranceof occlusive vascular events, in the laboratory studies failure of suppressionof thrombocyte functions compared to cases that normally respond to aspirinhas been defined as aspirin resistance. 2n this study aspirin resistance wasevaluated in coronary artery disease patients with PFA-100 system.In the study 97 patients that routinely used 100 mg or higher aspirin forfour weeks and that had coronary angiograhic examination were included. 2nthe cases with PFA-100 system aspirin resistance was determined.When all the cases were examined in case of aspirin resistance, it wasmore frequent in the cases with coronary artey disease (p:0,02). In the groupwith coronary artery disease (60 patients), patients with aspirin resistancemore frequently smoked smoking (p:0.001), and the LDL-C values (p:0,02)and T.Chol/HDL cholesterol levels (p:0,02) were significantly highercompared to the aspirin sensitive patients. When the cases with CAD werecompared according to the aspirin dose they had (100mg ve 300mg) the twogroups did not differ significantly (p:0,46). The patients with CAD weredivided into three goups accord ng to the number of d seased vessels. Group1 was constituted of cases with one vessel disease (n:21, %35), group 2 twovessel disease (n:16, %26) and group 3 was constituted of patients withthree vessel disease (n:23, %38). There no was statistically significantdifference in terms of aspirin resistance between the groups 1 and 2 (p:0.26);1 and 3 (p:0,8); and the groups 2 and 3 (p:0,35).As a result, it was shown that the responses were not the same inpatients taking aspirin. It was concluded tahat in cases with CAD adequacyvof aspirin response may be quickly evaluated by PFA-100 system and thetherapy may be adjusted according to the resultsKeywords: Coronary artery disease, aspirin resistance, PFA-100system.vi 53
- Published
- 2006
21. Left Ventricular Functions and Its Relation with Grade of Hepatosteatosis in Non-Alcholic Fatty Liver Disease
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Karaağaç, Kemal, primary, Bekler, Adem, additional, Vatansever, Fahriye, additional, Özlük, Özlem Arıcan, additional, Tenekecioğu, Erhan, additional, Yılmaz, Mustafa, additional, and Peker, Tezcan, additional
- Published
- 2013
- Full Text
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22. Predictive value of atrial electromechanical delay for atrial fibrillation recurrence
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Ari, Hasan, primary, Ari, Selma, additional, Akkaya, Mehmet, additional, Aydin, Cihan, additional, Emlek, Nadir, additional, Sarigül, O. Yaşar, additional, Çetinkaya, Seçkin, additional, Bozat, Tahsin, additional, Şentürk, Muhammet, additional, Karaağaç, Kemal, additional, Melek, Mehmet, additional, and Yilmaz, Mustafa, additional
- Published
- 2013
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23. Arterial Elasticity Measurement in Patients with Behcet's Disease
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Uçar, Hakan, primary, Karaağaç, Kemal, additional, Serdar, Osman Akın, additional, Sarıcaoğlu, Hayriye, additional, and Aktürk, Yusuf, additional
- Published
- 2013
- Full Text
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24. Spontaneous Coronary Artery Dissection: Case Report Review of the Literature
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Karaağaç, Kemal, primary, Arıcan Özlük, Özlem, additional, Yılmaz, Mustafa, additional, and Topal, Dursun, additional
- Published
- 2013
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25. The Effects of Metabolic Syndrome on TpTe Interval and TpTe/QT Ratio in Patients with Normal Coronary Arteries.
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Karaağaç, Kemal, Emul, Ali, Tenekecioglu, Erhan, Ağca, Fahriye Vatansever, Ozluk, Özlem Arican, Tutuncu, Ahmet, Yontar, Osman Can, and Yilmaz, Mustafa
- Subjects
- *
ARRHYTHMIA , *CHI-squared test , *CORONARY arteries , *ECHOCARDIOGRAPHY , *ELECTROCARDIOGRAPHY , *T-test (Statistics) , *TIME , *METABOLIC syndrome , *MANN Whitney U Test - Abstract
Objective: T wave peak to T wave end (TpTe) interval and TpTe/QT have been accepted as predictors of ventricular arrythmia. In this study our aim is to investigate the effect of metabolic syndome on these parameters in patients with angiographically normal coronary arteries. Materials and Methods: Thirty patients with metabolic syndrome (4 male, mean age 52±7.8 years) and twenty patients without metabolic syndrome as control group (8 male, mean age 54±9.3 years) were included. TpTe interval and TpTe/QT ratio were measured from the 12- lead electrocardiogram. These parameters were compared between the groups Results: When compared with to the control group the systolic and diastolic blood pressure, pulse pressure, waist circumference, triglyceride and fasting plasma glucose levels were higher and HDL cholesterol level was lower in the metabolic syndrome group. In the analysis of electrocardiography, QT dispersion (QTd) and corrected QTd were significantly increased in metabolic syndrome group as compared to the controls group (44±14 versus 30±12 ms and 433±10 versus 405±4 ms, all p value p=0.01). TpTe interval and TpTe/QT ratio were also significantly higher in patient with metabolic syndrome (112±10 versus 91 ±10 ms and 0.25±0.02 versus 0.22±0.01, all p value p=0.01). Conclusion: According to these results, we supposed that TpTe/QT ratio and TpTe interval is prolonged and those patients with metabolic syndrome may be at greater risk of ventricular arrhythmias. [ABSTRACT FROM AUTHOR]
- Published
- 2014
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26. Olanzapin Kullanımı QT İntervali Normal Ölçülen Hastalarda T Dalga Tepe- T Dalga Sonlanım Noktaları İntervalini Uzatır.
- Author
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Yontar, Osman Can, Yontar, Gözde, Tütüncü, Ahmet, Karaağaç, Kemal, Tenekecioğlu, Erhan, Karakuş, Alper, and Melek, Mehmet
- Abstract
Copyright of Journal of Harran University Medical Faculty / Harran Üniversitesi Tıp Fakültesi Dergisi is the property of Harran University Medical Faculty and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
- Published
- 2014
27. The Effect of On-pump Coronary Artery By-pass Surgery on Aortic Functions
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Ağca, Fahriye Vatansever, Karaagac, Kemal, Peker, Tezcan, Arıcan Ozluk, Ozlem, Tenekecioğu, Erhan, Şenturk, Muhammed, and Yılmaz, Mustafa
- Published
- 2013
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28. Left Atrial Mechanical Functions, Atrial Electromechanical Delay and P Wave Dispersion in Patients with Mild to Moderate Psoriasis
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Özlük, Fatma Özlem Arıcan, Yılmaz, Mustafa, Yazıcı, Serkan, Peker, Tezcan, Topal, Dursun, Karaagac, Kemal, Vatansever, Fahriye, Akgumus, Alkame, and Tenekecioglu, Erhan
- Published
- 2013
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29. Arterial Dysfunction in Early Autosomal Dominant Polycystic Kidney Disease Independent of Fibroblast Growth Factor 23.
- Author
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Yildiz, Abdulmecit, Gul, Cuma Bulent, Ersoy, Alparslan, Asiltas, Burak, Ermurat, Selime, Dogan, Selda, Karaağaç, Kemal, Sag, Saim, Oruc, Aysegul, Aktas, Nimet, Ocakoglu, Gokhan, Dogan, Ibrahim, Gullulu, Sumeyye, and Gullulu, Mustafa
- Subjects
- *
CYTOKINES , *HUMAN growth hormone , *DEVELOPMENTAL biology , *POLYCYSTIC kidney disease ,ARTERIAL abnormalities - Abstract
Introduction. Recent studies report reduced vascular compliance and elevated levels of fibroblast growth factor 23 (FGF23) in patients with autosomal dominant polycystic kidney disease (ADPKD) and preserved kidney function. In the present study, we investigated the relationship between vascular compliance and FGF23 in patients in early phases of ADPKD. Materials and Methods. We studied 54 ADPKD patients with preserved kidney function and 24 healthy individuals. All participants underwent noninvasive pulse wave analysis in order to determine large arterial elasticity index (LAEI) and small arterial elasticity index (SAEI) using a modified Windkessel model. Levels of FGF23 in addition to several cardiovascular risk factors were evaluated. Linear regression analyses were performed to determine independent correlates of LAEI, SAEI, and FGF23. Results. In the ADPKD group, 33 patients were hypertensive and the remaining patients were normotensive. Serum FGF23 levels of both ADPKD groups were significantly higher than that in the controls. Both hypertensive and normotensive ADPKD patients had lower LAEI and SAEI levels compared to the controls. There was no significant correlation between vascular compliance parameters and FGF23 levels. Having ADPKD was independently associated with increased FGF23 levels and decreased SAEI. Conclusions. Fibroblast growth factor 23 was found substantially elevated and arterial compliance was found significantly decreased in early ADPKD patients regardless of hypertension. However, there was no significant correlation between FGF23 levels and arterial function parameters. Additional studies are required to determine possible mechanisms of these disturbances and cardiovascular effects of FGF23 in ADPKD patients. [ABSTRACT FROM AUTHOR]
- Published
- 2014
30. Left ventricular hemangioma.
- Author
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Arı H, Arı S, Günay T, and Karaağaç K
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- Adult, Chest Pain, Coronary Angiography, Echocardiography, Heart Neoplasms physiopathology, Heart Neoplasms surgery, Heart Ventricles, Hemangioma physiopathology, Hemangioma surgery, Humans, Male, Heart Neoplasms diagnosis, Hemangioma diagnosis
- Abstract
Primary cardiac tumors of the ventricles are very uncommon. Cardiac hemangiomas are extremely rare primary benign cardiac tumors that are often asymptomatic and are typically diagnosed incidentally during an echocardiographic examination. We report the case of a 27-year-old male who was referred to our hospital complaining of atypical chest pain over the last three months. The pain was unrelated to exercise, and consisted of 1-2 minutes of ongoing, stinging chest pain followed by 2-3 seconds of ongoing palpitations. His physical examination was unremarkable, his blood pressure was 130/80 mmHg, his ECG was sinus rhythm, and his heart rate was 82 beats/min. A transthoracic echocardiogram revealed a mobile 1.20x1.28 cm mass in the left ventricular cavity at the antero-lateral wall. Subsequent coronary angiography was performed to determine the vascular supply for the mass, and showed late opacification of a well-vascularized left ventricle mass from the second diagonal artery. Surgery was performed and the mass was complete resected. The pathological and histological examination of the resected mass showed that it was a hemangioma. The patient was discharged 5 days after surgery without symptoms.
- Published
- 2012
- Full Text
- View/download PDF
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