Search

Your search keyword '"Kapoor, M"' showing total 1,496 results
Start Over Author "Kapoor, M"
1,496 results on '"Kapoor, M"'

3. High Polygenic Risk Scores Are Associated With Early Age of Onset of Alcohol Use Disorder in Adolescents and Young Adults at Risk

Author

Nurnberger, John I, Wang, Yumin, Zang, Yong, Lai, Dongbing, Wetherill, Leah, Edenberg, Howard J, Aliev, Fazil, Plawecki, Martin H, Chorlian, David, Chan, Grace, Bucholz, Kathleen, Bauer, Lance, Kamarajan, Chella, Salvatore, Jessica E, Kapoor, Manav, Hesselbrock, Victor, Dick, Danielle, Bierut, Laura, McCutcheon, Vivia, Meyers, Jacquelyn L, Porjesz, Bernice, Kramer, John, Kuperman, Samuel, Kinreich, Sivan, Anokhin, Andrey P, Porjesz, B, Hesselbrock, V, Foroud, T, Agrawal, A, Dick, D, Edenberg, HJ, Nurnberger, J, Liu, Y, Kuperman, S, Kramer, J, Meyers, J, Kamarajan, C, Pandey, A, Bierut, L, Rice, J, Bucholz, K, Schuckit, M, Tischfield, J, Brooks, A, Hart, R, Almasy, L, Salvatore, J, Goate, A, Kapoor, M, Slesinger, P, Scott, D, Bauer, L, Wetherill, L, Xuei, X, Lai, D, O’Connor, S, Plawecki, M, Zang, Y, Acion, L, Chan, G, Chorlian, DB, Zhang, J, Kinreich, S, Pandey, G, Chao, M, Anokhin, A, McCutcheon, V, Saccone, S, Aliev, F, Barr, P, Chin, H, and Parsian, A

Subjects
Biological Sciences, Biomedical and Clinical Sciences, Genetics, Epidemiology, Health Sciences, Prevention, Substance Misuse, Underage Drinking, Alcoholism, Alcohol Use and Health, Pediatric, Clinical Research, Mental health, Good Health and Well Being, Collaborative Study on the Genetics of Alcoholism, Alcohol use disorder, Clinical variables, Polygenic risk scores, Prediction of illness, Receiver operating characteristics curves, Survival analysis
Abstract

BackgroundGenome-wide association studies have been conducted in alcohol use disorder (AUD), and they permit the use of polygenic risk scores (PRSs), in combination with clinical variables, to predict the onset of AUD in vulnerable populations.MethodsA total of 2794 adolescent/young adult subjects from the Collaborative Study on the Genetics of Alcoholism were followed, with clinical assessments every 2 years. Subjects were genotyped using a genome-wide chip. Separate PRS analyses were performed for subjects of European ancestry and African ancestry. Age of onset of DSM-5 AUD was evaluated using the Cox proportional hazard model. Predictive power was assessed using receiver operating characteristic curves and by analysis of the distribution of PRS.ResultsEuropean ancestry subjects with higher than median PRSs were at greater risk for onset of AUD than subjects with lower than median PRSs (p = 3 × 10-7). Area under the curve for the receiver operating characteristic analysis peaked at 0.88 to 0.95 using PRS plus sex, family history, comorbid disorders, age at first drink, and peer drinking; predictive power was primarily driven by clinical variables. In this high-risk sample, European ancestry subjects with a PRS score in the highest quartile showed a 72% risk for developing AUD and a 35% risk of developing severe AUD (compared with risks of 54% and 16%, respectively, in the lowest quartile).ConclusionsPredictive power for PRSs in the extremes of the distribution suggests that these may have future clinical utility. Uncertainties in interpretation at the individual level still preclude current application.

Published
2022

6. POS0213 INFRAPATELLAR FAT PAD IN KNEE OSTEOARTHRITIS: CELLULAR AND TRANSCRIPTOMIC ATLAS

Author

Peters, H., primary, Potla, P., additional, Rockel, J., additional, Tockovska, T., additional, Delos Santos, K., additional, Vohra, S., additional, Pastrello, C., additional, Jurisica, I., additional, Lively, S., additional, Perry, K., additional, Perruccio, A., additional, Mahomed, N., additional, Rampersaud, R., additional, Krawetz, R., additional, Buechler, M., additional, Gandhi, R., additional, and Kapoor, M., additional

Published
2024
Full Text
View/download PDF

7. OP0066 FIBROBLAST ACTIVATION DEFINES DISEASE PROGRESSION: SYNOVIUM ATLAS IN KNEE OSTEOARTHRITIS

Author

Thavaratnam, K., primary, Gracey, E., additional, Ratneswaran, A., additional, Rockel, J., additional, Vohra, S., additional, Pastrello, C., additional, Jurisica, I., additional, Lively, S., additional, Vlieghe, C., additional, Planckaert, G., additional, Dupont, S., additional, Rampersaud, R., additional, Mahomed, N., additional, Gandhi, R., additional, Elewaut, D., additional, and Kapoor, M., additional

Published
2024
Full Text
View/download PDF

9. High Polygenic Risk Scores Are Associated With Early Age of Onset of Alcohol Use Disorder in Adolescents and Young Adults at Risk

Author

Porjesz, B., Hesselbrock, V., Foroud, T., Agrawal, A., Dick, D., Edenberg, H.J., Nurnberger, J., Jr., Liu, Y., Kuperman, S., Kramer, J., Meyers, J., Kamarajan, C., Pandey, A., Bierut, L., Rice, J., Bucholz, K., Schuckit, M., Tischfield, J., Brooks, A., Hart, R., Almasy, L., Salvatore, J., Goate, A., Kapoor, M., Slesinger, P., Scott, D., Bauer, L., Wetherill, L., Xuei, X., Lai, D., O’Connor, S., Plawecki, M., Zang, Y., Acion, L., Chan, G., Chorlian, D.B., Zhang, J., Kinreich, S., Pandey, G., Chao, M., Anokhin, A., McCutcheon, V., Saccone, S., Aliev, F., Barr, P., Chin, H., Parsian, A., Nurnberger, John I., Jr., Wang, Yumin, Zang, Yong, Lai, Dongbing, Wetherill, Leah, Edenberg, Howard J., Aliev, Fazil, Plawecki, Martin H., Chorlian, David, Chan, Grace, Bucholz, Kathleen, Bauer, Lance, Kamarajan, Chella, Salvatore, Jessica E., Kapoor, Manav, Hesselbrock, Victor, Dick, Danielle, Bierut, Laura, McCutcheon, Vivia, Meyers, Jacquelyn L., Porjesz, Bernice, Kramer, John, Kuperman, Samuel, Kinreich, Sivan, and Anokhin, Andrey P.

Published
2022
Full Text
View/download PDF

12. A deep catalogue of protein-coding variation in 983,578 individuals.

Author

Sun, KY, Bai, X, Chen, S, Bao, S, Zhang, C, Kapoor, M, Backman, J, Joseph, T, Maxwell, E, Mitra, G, Gorovits, A, Mansfield, A, Boutkov, B, Gokhale, S, Habegger, L, Marcketta, A, Locke, AE, Ganel, L, Hawes, A, Kessler, MD, Sharma, D, Staples, J, Bovijn, J, Gelfman, S, Di Gioia, A, Rajagopal, VM, Lopez, A, Varela, JR, Alegre-Díaz, J, Berumen, J, Tapia-Conyer, R, Kuri-Morales, P, Torres, J, Emberson, J, Collins, R, Regeneron Genetics Center, RGC-ME Cohort Partners, Cantor, M, Thornton, T, Kang, HM, Overton, JD, Shuldiner, AR, Cremona, ML, Nafde, M, Baras, A, Abecasis, G, Marchini, J, Reid, JG, Salerno, W, Balasubramanian, S, Sun, KY, Bai, X, Chen, S, Bao, S, Zhang, C, Kapoor, M, Backman, J, Joseph, T, Maxwell, E, Mitra, G, Gorovits, A, Mansfield, A, Boutkov, B, Gokhale, S, Habegger, L, Marcketta, A, Locke, AE, Ganel, L, Hawes, A, Kessler, MD, Sharma, D, Staples, J, Bovijn, J, Gelfman, S, Di Gioia, A, Rajagopal, VM, Lopez, A, Varela, JR, Alegre-Díaz, J, Berumen, J, Tapia-Conyer, R, Kuri-Morales, P, Torres, J, Emberson, J, Collins, R, Regeneron Genetics Center, RGC-ME Cohort Partners, Cantor, M, Thornton, T, Kang, HM, Overton, JD, Shuldiner, AR, Cremona, ML, Nafde, M, Baras, A, Abecasis, G, Marchini, J, Reid, JG, Salerno, W, and Balasubramanian, S

Abstract

Rare coding variants that substantially affect function provide insights into the biology of a gene1-3. However, ascertaining the frequency of such variants requires large sample sizes4-8. Here we present a catalogue of human protein-coding variation, derived from exome sequencing of 983,578 individuals across diverse populations. In total, 23% of the Regeneron Genetics Center Million Exome (RGC-ME) data come from individuals of African, East Asian, Indigenous American, Middle Eastern and South Asian ancestry. The catalogue includes more than 10.4 million missense and 1.1 million predicted loss-of-function (pLOF) variants. We identify individuals with rare biallelic pLOF variants in 4,848 genes, 1,751 of which have not been previously reported. From precise quantitative estimates of selection against heterozygous loss of function (LOF), we identify 3,988 LOF-intolerant genes, including 86 that were previously assessed as tolerant and 1,153 that lack established disease annotation. We also define regions of missense depletion at high resolution. Notably, 1,482 genes have regions that are depleted of missense variants despite being tolerant of pLOF variants. Finally, we estimate that 3% of individuals have a clinically actionable genetic variant, and that 11,773 variants reported in ClinVar with unknown significance are likely to be deleterious cryptic splice sites. To facilitate variant interpretation and genetics-informed precision medicine, we make this resource of coding variation from the RGC-ME dataset publicly accessible through a variant allele frequency browser.

Published
2024

24. Oral Delivery Of Delta-9-Tetrahydrocannabinol Provides Symptom And Disease Modification In A Mouse Model Of Knee Osteoarthritis

Author

Rockel, J.S., primary, Maglaviceanu, A., additional, Filippini, H. Fetter, additional, Wasilewski, E., additional, Lewis-Bakker, M.M., additional, Gabrial, S., additional, Rossomacha, E., additional, Garcia, J., additional, Leroux, T., additional, Clarke, H., additional, Bonin, R.P., additional, Kotra, L.P., additional, and Kapoor, M., additional

Published
2023
Full Text
View/download PDF

26. Supportive Evidence For The Potential For Novel Biodiscovery In Osteoarthritis Through The Stepup Oa Consortium

Author

Perry, T.A., primary, Deng, Y., additional, Hulley, P., additional, Maciewicz, R.A., additional, Mitchelmore, J., additional, Perry, D., additional, Larsson, S., additional, Lemire, S., additional, Struglics, A., additional, Appleton, C.T., additional, Kluzek, S., additional, Arden, N.K., additional, Felson, D.T., additional, Marsden, B., additional, Tom, B.D., additional, Bondi, L., additional, Kapoor, M., additional, Kumar, V., additional, Lohmander, L.S., additional, Welting, T.J., additional, Walsh, D.A., additional, Valdes, A.M., additional, Jostins-Dean, L., additional, Watt, F.E., additional, and Vincent, T.L., additional

Published
2023
Full Text
View/download PDF

29. An endophenotype approach to the genetics of alcohol dependence: a genome wide association study of fast beta EEG in families of African ancestry

Author

Meyers, J L, Zhang, J, Wang, J C, Su, J, Kuo, S I, Kapoor, M, Wetherill, L, Bertelsen, S, Lai, D, Salvatore, J E, Kamarajan, C, Chorlian, D, Agrawal, A, Almasy, L, Bauer, L, Bucholz, K K, Chan, G, Hesselbrock, V, Koganti, L, Kramer, J, Kuperman, S, Manz, N, Pandey, A, Seay, M, Scott, D, Taylor, R E, Dick, D M, Edenberg, H J, Goate, A, Foroud, T, and Porjesz, B

Published
2017
Full Text
View/download PDF

33. 4P FAT1: A novel modulator of autophagy in human glioblastoma

Author

Gupta, Y., primary, Malik, N., additional, Goswami, S., additional, Arora, M., additional, Kundu, A., additional, Gupta, S., additional, Kapoor, M., additional, Suri, V., additional, Suri, A., additional, Chattopadhyay, P., additional, Sinha, S., additional, and Chosdol, K., additional

Published
2023
Full Text
View/download PDF

34. Added value of the measles-rubella supplementary immunization activity in reaching unvaccinated and under-vaccinated children, a cross-sectional study in five Indian districts, 2018–20

Author

Prosperi, C., primary, Thangaraj, J.W.V., additional, Hasan, A.Z., additional, Kumar, M.S., additional, Truelove, S., additional, Kumar, V.S., additional, Winter, A.K., additional, Bansal, A.K., additional, Chauhan, S.L., additional, Grover, G.S., additional, Jain, A.K., additional, Kulkarni, R.N., additional, Sharma, S.K., additional, Soman, B., additional, Chaaithanya, I.K., additional, Kharwal, S., additional, Mishra, S.K., additional, Salvi, N.R., additional, Sharma, N.P., additional, Sharma, S., additional, Varghese, A., additional, Sabarinathan, R., additional, Duraiswamy, A., additional, Rani, D.S., additional, Kanagasabai, K., additional, Lachyan, A., additional, Gawali, P., additional, Kapoor, M., additional, Chonker, S.K., additional, Cutts, F.T., additional, Sangal, L., additional, Mehendale, S.M., additional, Sapkal, G.N., additional, Gupta, N., additional, Hayford, K., additional, Moss, W.J., additional, and Murhekar, M.V., additional

Published
2023
Full Text
View/download PDF

38. Polygenic Risk Score Prediction of Alcohol Dependence Symptoms Across Population‐Based and Clinically Ascertained Samples

Author

Savage, Jeanne E., Salvatore, Jessica E., Aliev, Fazil, Edwards, Alexis C., Hickman, Matthew, Kendler, Kenneth S., Macleod, John, Latvala, Antti, Loukola, Anu, Kaprio, Jaakko, Rose, Richard J., Chan, Grace, Hesselbrock, Victor, Webb, Bradley T., Adkins, Amy, Bigdeli, Tim B., Riley, Brien P., Dick, Danielle M., Porjesz, B., Edenberg, H., Bierut, L., Nurnberger, J., Foroud, T., Kuperman, S., Kramer, J., Rice, J., Bucholz, K., Agrawal, A., Schuckit, M., Tischfield, J., Brooks, A., Almasy, L., Goate, A., Taylor, R., Bauer, L., McClintick, J., Wetherill, L., Xuei, X., Liu, Y., Lai, D., OʼConnor, S., Plawecki, M., Lourens, S., Meyers, J., Chorlian, D., Kamarajan, C., Pandey, A., Zhang, J., Wang, J.‐C., Kapoor, M., Bertelsen, S., Anokhin, A., McCutcheon, V., Saccone, S., Cho, B., Parsian, A., and Reilly, M.

Published
2018
Full Text
View/download PDF

39. Variation in SWI/SNF Chromatin Remodeling Complex Proteins is Associated with Alcohol Dependence and Antisocial Behavior in Human Populations

Author

Mathies, Laura D., Aliev, Fazil, Davies, Andrew G., Dick, Danielle M., Bettinger, Jill C., Porjesz, B., Hesselbrock, V., Edenberg, H., Bierut, L., Nurnberger, J., Jr., Foroud, T., Kuperman, S., Kramer, J., Porjesz, B., Bierut, L., Rice, J., Bucholz, K., Agrawal, A., Schuckit, M., Tischfield, J., Brooks, A., Almasy, L., Goate, A., Taylor, R., Bauer, L., McClintick, J., Wetherill, L., Xuei, X., Liu, Y., Lai, D., OʼConnor, S., Plawecki, M., Lourens, S., Chan, G., Meyers, J., Chorlian, D., Kamarajan, C., Pandey, A., Zhang, J., Wang, J.‐C., Kapoor, M., Bertelsen, S., Anokhin, A., McCutcheon, V., Saccone, S., Salvatore, J., Cho, B., Kos, M., Parsian, A., and Reilly, M.

Published
2017
Full Text
View/download PDF

40. Evidence of CNIH3 involvement in opioid dependence

Author

Nelson, E C, Agrawal, A, Heath, A C, Bogdan, R, Sherva, R, Zhang, B, Al-Hasani, R, Bruchas, M R, Chou, Y-L, Demers, C H, Carey, C E, Conley, E D, Fakira, A K, Farrer, L A, Goate, A, Gordon, S, Henders, A K, Hesselbrock, V, Kapoor, M, Lynskey, M T, Madden, P A F, Moron, J A, Rice, J P, Saccone, N L, Schwab, S G, Shand, F L, Todorov, A A, Wallace, L, Wang, T, Wray, N R, Zhou, X, Degenhardt, L, Martin, N G, Hariri, A R, Kranzler, H R, Gelernter, J, Bierut, L J, Clark, D J, and Montgomery, G W

Published
2016
Full Text
View/download PDF

41. Restricting Branched-Chain Amino Acids within a High-Fat Diet Prevents Obesity.

Author

Liu, M, Huang, Y, Zhang, H, Aitken, D, Nevitt, MC, Rockel, JS, Pelletier, J-P, Lewis, CE, Torner, J, Rampersaud, YR, Perruccio, AV, Mahomed, NN, Furey, A, Randell, EW, Rahman, P, Sun, G, Martel-Pelletier, J, Kapoor, M, Jones, G, Felson, D, Qi, D, Zhai, G, Liu, M, Huang, Y, Zhang, H, Aitken, D, Nevitt, MC, Rockel, JS, Pelletier, J-P, Lewis, CE, Torner, J, Rampersaud, YR, Perruccio, AV, Mahomed, NN, Furey, A, Randell, EW, Rahman, P, Sun, G, Martel-Pelletier, J, Kapoor, M, Jones, G, Felson, D, Qi, D, and Zhai, G

Abstract

Obesity is a global pandemic, but there is yet no effective measure to control it. Recent metabolomics studies have identified a signature of altered amino acid profiles to be associated with obesity, but it is unclear whether these findings have actionable clinical potential. The aims of this study were to reveal the metabolic alterations of obesity and to explore potential strategies to mitigate obesity. We performed targeted metabolomic profiling of the plasma/serum samples collected from six independent cohorts and conducted an individual data meta-analysis of metabolomics for body mass index (BMI) and obesity. Based on the findings, we hypothesized that restriction of branched-chain amino acids (BCAAs), phenylalanine, or tryptophan may prevent obesity and tested our hypothesis in a dietary restriction trial with eight groups of 4-week-old male C57BL/6J mice (n = 5/group) on eight different types of diets, respectively, for 16 weeks. A total of 3397 individuals were included in the meta-analysis. The mean BMI was 30.7 ± 6.1 kg/m2, and 49% of participants were obese. Fifty-eight metabolites were associated with BMI and obesity (all p ≤ 2.58 × 10-4), linked to alterations of the BCAA, phenylalanine, tryptophan, and phospholipid metabolic pathways. The restriction of BCAAs within a high-fat diet (HFD) maintained the mice's weight, fat and lean volume, subcutaneous and visceral adipose tissue weight, and serum glucose and insulin at levels similar to those in the standard chow group, and prevented obesity, adipocyte hypertrophy, adipose inflammation, and insulin resistance induced by HFD. Our data suggest that four metabolic pathways, BCAA, phenylalanine, tryptophan, and phospholipid metabolic pathways, are altered in obesity and restriction of BCAAs within a HFD can prevent the development of obesity and insulin resistance in mice, providing a promising strategy to potentially mitigate diet-induced obesity.

Published
2022

47. ASSOCIATION OF PRESURGICAL CIRCULATING MICRORNAS WITH 1-YEAR POSTSURGICAL PAIN REDUCTION IN SPINE FACET OSTEOARTHRITIS PATIENTS WITH LUMBAR SPINAL STENOSIS

Author

Lively, S., primary, Milliot, M., additional, Potla, P., additional, Espin-Garcia, O., additional, Layeghifard, M., additional, Sundararajan, K., additional, Endisha, H., additional, Nakamura, A., additional, Perruccio, A.V., additional, Veillette, C., additional, Kapoor, M., additional, and Rampersaud, Y., additional

Published
2022
Full Text
View/download PDF

50. List of Contributors

Author

Abraham, R.E., primary, Alberti, A., additional, Awan, A.T., additional, Capalash, N., additional, Carvalho, F., additional, de Carvalho, J.C., additional, de la Luz Mora, M., additional, de Souza Vandenberghe, L.P., additional, Deshmukh, S.K., additional, Devatkal, S., additional, Dhillon, G.S., additional, Fernandes, P., additional, Gianfreda, L., additional, Gomes, T.A., additional, Gopalan, N., additional, Kaira, G.S., additional, Kapoor, M., additional, Kaur, K., additional, Kumar, U., additional, Libardi, N., additional, Muzaddadi, A.U., additional, Nampoothiri, K.M., additional, Nogueira, A., additional, Oberoi, H.S., additional, Panwar, D., additional, Puri, M., additional, Puri, S., additional, Queiroz, V.L., additional, Raj, S.R.F., additional, Rao, M.A., additional, Rodrigues, C., additional, Scelza, R., additional, Sharma, P., additional, Sharma, R., additional, Singh, G., additional, Soccol, C.R., additional, Spier, M.R., additional, Sunar, K., additional, Tasic, L., additional, Ugwuanyi, J.O., additional, Vijayaraghavan, P., additional, and Vincent, S.G.P., additional

Published
2016
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results