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1. APASL clinical practice guidelines on the management of acute kidney injury in acute-on-chronic liver failure

Author

Maiwall, Rakhi, Singh, Satender Pal, Angeli, Paolo, Moreau, Richard, Krag, Aleksander, Singh, Virender, Singal, Ashwani K., Tan, S. S., Puri, Puneet, Mahtab, Mamun, Lau, George, Ning, Qin, Sharma, Manoj Kumar, Rao, P. N., Kapoor, Dharmesh, Gupta, Subhash, Duseja, Ajay, Wadhawan, Manav, Jothimani, Dinesh, Saigal, Sanjiv, Taneja, Sunil, Shukla, Akash, Puri, Pankaj, Govil, Deepak, Pandey, Gaurav, Madan, Kaushal, Eapen, C. E., Benjamin, Jaya, Chowdhury, Ashok, Singh, Shweta, Salao, Vaishali, Yang, Jin Mo, Hamid, Saeed, Shalimar, Jasuja, Sanjiv, Kulkarni, Anand V., Niriella, Madund A., Tevethia, Harsh Vardhan, Arora, Vinod, Mathur, R. P., Roy, Akash, Jindal, Ankur, Saraf, Neeraj, Verma, Nipun, De, Arka, Choudhary, Narendra S., Mehtani, Rohit, Chand, Phool, Rudra, Omkar, and Sarin, Shiv Kumar

Published
2024
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4. Preventing Small-for-size Syndrome in Living Donor Liver Transplantation: Guidelines From the ILTS-iLDLT-LTSI Consensus Conference

Author

Hakeem, Abdul Rahman, Mathew, Johns Shaji, Aunés, Carmen Vinaixa, Mazzola, Alessandra, Alconchel, Felipe, Yoon, Young-In, Testa, Giuliano, Selzner, Nazia, Sarin, Shiv Kumar, Lee, Kwang-Woong, Soin, Arvinder, Pomposelli, James, Menon, Krishna, Goyal, Neerav, Kota, Venugopal, Abu-Gazala, Samir, Rodriguez-Davalos, Manuel, Rajalingam, Rajesh, Kapoor, Dharmesh, Durand, Francois, Kamath, Patrick, Jothimani, Dinesh, Sudhindran, Surendran, Vij, Vivek, Yoshizumi, Tomoharu, Egawa, Hiroto, Lerut, Jan, Broering, Dieter, Berenguer, Marina, Cattral, Mark, Clavien, Pierre-Alain, Chen, Chao-Long, Shah, Samir, Zhu, Zhi-Jun, Ascher, Nancy, Bhangui, Prashant, Rammohan, Ashwin, Emond, Jean, and Rela, Mohamed

Published
2023
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6. LUTS Assessment

Author

Bray, Alison, Cashman, Sophia, Cotterill, Nikki, Drake, Marcus, Fode, Mikkel, Gammie, Andrew, Harding, Christopher, Kapoor, Dharmesh, Thiruchelvam, Nikesh, Thomas, Laura, Uren, Alan D., Drake, Marcus, editor, Cocci, Andrea, editor, and Pereira e Silva, Ricardo, editor

Published
2020
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7. Selonsertib for patients with bridging fibrosis or compensated cirrhosis due to NASH: Results from randomized phase III STELLAR trials

Author

Gadano, Adrian, Martins, Marcelo, Angus, Peter, Bate, John, Danta, Mark, George, Jacob, Hodge, Alexander, Kontorinis, Nickolas, Roberts, Stuart, Sanagapalli, Santosh, Skoien, Richard, Thompson, Alexander, Zekry, Amany, Stauber, Rudolf, Trauner, Michael, Moreno, Christophe, Reynaert, Hendrik, Verbeke, Len, Silva, Mario Reis Alvares da, Parise, Edison, Oliveira, Claudia Pinto Marques Souza de, Araujo, Roberta Chaves, Martinelli, Ana de Lourdes Candolo, Borman, Meredith, Chandok, Natasha, Elkhashab, Magdy, Fraser, Hughie, Kaita, Kelly, Ma, Mang, Marotta, Paul, Ramji, Alnoor, Tam, Edward, Yoshida, Eric, Swain, Mark, Sebastiani, Giada, Petrunia, Denis, Abergel, Armando, Anty, Rodolphe, Bourlière, Marc, Boursier, Jérôme, Bureau, Christophe, Castera, Laurent, Habersetzer, François, Hézode, Christophe, Ledinghen, Victor De, Leroy, Vincent, Loustaud-Ratti, Véronique, Mathurin, Philippe, Pol, Stanislas, Zoulim, Fabien, Hinrichsen, Holger, Ingiliz, Patrick, Lammert, Frank, Manns, Michael, Schattenberg, Jörn, Schiefke, Ingolf, Trautwein, Christian, Zeuzem, Stefan, Hui, Aric, Li, King-Kong, Wong, Vincent, Acharya, Subrat, Chowdhury, Abhijit, Duseja, Ajay, Kapoor, Dharmesh, Mukewar, Shrikant, Sarin, Shiv, Shah, Samir, Shalimar, Sood, Ajit, Tantry, BV, Ben-Ari, Ziv, Katchman, Helena, Safadi, Rifaat, Veitsman, Ella, Zuckerman, Eli, Brunetto, Maurizia, Lampertico, Pietro, Mangia, Alessandra, Akahane, Takemi, Akuta, Norio, Eguchi, Yuichiro, Fujiyama, Shigetoshi, Genda, Takuya, Hiasa, Yoichi, Ido, Akio, Ikeda, Fusao, Ikegami, Tadashi, Imajo, Kento, Itoh, Yoshito, Iwasa, Motoh, Karino, Yoshiyasu, Kato, Naoya, Kawaguchi, Takumi, Kawanaka, Miwa, Kido, Masahiro, Kobayashi, Tomoo, Kurosaki, Masayuki, Matsuzaki, Yasushi, Mita, Eiji, Mizukoshi, Eishiro, Nakahara, Takashi, Nomura, Hideyuki, Notsumata, Kazuo, Okanoue, Takeshi, Saito, Satoshi, Sakugawa, Hiroshi, Suzuki, Yoshiyuki, Takaguchi, Koichi, Takaki, Akinobu, Takashima, Tomoyuki, Tanaka, Saiyu, Tsuji, Keiji, Ueno, Yoshiyuki, Umemura, Takeji, Uto, Hirofumi, Yamashita, Nobuyuki, Yanase, Mikio, Yatsuhashi, Hiroshi, Yoneda, Masashi, Chan, Wah Kheong, Tan, Soek Siam, Garza, Laura Cisneros, Ladron De Guevara Cetina, Alma, Angeles, Rocio Guadalupe Vargas, Silva, Francisca Martinez, Van Erpecum, Karel, Orr, David, Jabłkowski, Maciej, Jaroszewicz, Jerzy, Ramos, Jose, Ahmed, Taufique, Ang, Tiing, Dan, Yock young, Goh, Boon Bee, Kaliyaperumal, Kalaiyarasi, Yip, Cherng Hann, Baik, Soon Koo, Jang, Byoung Kuk, Jun, Dae Won, Kim, Won, Kim, Hyung Joon, Kim, Ji Hoon, Lee, Kwan Sik, Lee, Chun Kyon, Lim, Young-Suk, Park, Jun Yong, Tak, Won Young, Augustin, Salvador, Perez, Salvador Benlloch, Caballeria, Juan, Luis, Jose, Panero, Calleja, Rodríguez, Jose Carrión, Garcia, Javier Crespo, Samaniego, Javier Garcia, Gibert, Pere Ginès, Prieto, Martin, Gomez, Manuel Romero, Turnes, Juan, Dufour, Jean-Francois, Moriggia, Alberto, Sheen, I-Shyan, Kao, Jia-Horng, Cheng, Pin-Nan, Huang, Jee-Fu, Yang, Sheng-Shun, Su, Wei-Wen, Chen, Chi-Yi, Chien, Rong-Nan, Lo, Gin-Ho, Chu, Chi-Jen, Wang, Horng-Yuan, Hu, Jui-Ting, Huang, Yi Wen, Agarwal, Kosh, Allison, Michael, Anstee, Quentin, Austin, Andrew, Fowell, Andrew, Ch'ng, Chin Lye, Manousou, Pinelopi, Newsome, Philip, Ryder, Stephen, Shankar, Arun, Abdelmalek, Manal, Abrams, Gary, Aguilar, Humberto, Alam, Imtiaz, Alba, Laura, Alkhouri, Naim, Allen, Alina, Aqel, Bashar, Balart, Luis, Barritt, A. Sidney, IV, Behari, Jaideep, Bennett, Michael, Bernstein, David, Bhandari, Bal Raj, Bonacini, Maurizio, Borg, Brian, Brown, Kimberly, Bzowej, Natalie, Caldwell, Stephen, Chami, Tawfik, Coates, Allan, Cueli, Adolfo, Davis, Mitchell, deLemos, Andrew, Desai, Archita, Dunn, Winston, Ferreira, Nelson, Fine, Michael, Firpi-Morell, Roberto, Freedland, Curtis, Freilich, Bradley, Fuchs, Michael, Galambos, Michael, Gallegos-Orozco, Juan, Galler, Greg, Ghali, Maged, Ghalib, Reem, Gill, Satinder, Gillis, Marcum, Gilroy, Richard, Gordon, Stuart, Gunn, Nadege, Halegoua-DeMarzio, Dina, Hassan, Mohamed, Hassanein, Tarek, Herring, Robert, Jr., Hong, John, Huang, Jonathan, Kabler, Heidi, Kayali, Zeid, Knapple, Whitfield, Kolli, Geetha, Kowdley, Kris, Krause, Richard, Lawitz, Eric, Lidofsky, Steven, Lim, Joseph, Lipkis, Donald, Loomba, Rohit, Mahgoub, Amar, Malespin, Miguel, Manch, Richard, Mannis, Steven, Manos, Paul, McDonald, Thomas, McKenzie, Mark, Mena, Edward, Merriman, Raphael, Moehlen, Martin William, Montgomery, Richard, Murphy, Robert, Natarajan, Yamini, Neff, Guy, Noureddin, Mazen, Ortiz-Lasanta, Grisell, Pagadala, Mangesh, Patel, Keyur, Patton, Heather, Peyton, Adam, Pimstone, Neville, Poulos, John, Pound, David, Pyrsopoulos, Nikolaos, Rafiq, Nila, Ravendhran, Natarajan, Ravinuthala, Ravi, Reddy, K. Rajendar, Reindollar, Robert, Reynolds, Justin, Rinella, Mary, Rizvi, Syed, Rockey, Don, Rodriguez-Perez, Federico, Ruane, Peter, Rubin, Raymond, Ryan, Michael, Saeian, Kia, Sanyal, Arun, Sarkar, Souvik, Scanga, Andrew, Schiff, Eugene, Schmidt, Warren, Schneider, Jeffrey, Sepe, Thomas, Shah, Dhiren, Shaikh, Obaid, Shankar, Uday, Sheikh, Aasim, Sheikh, Muhammad, Sherman, Kenneth, Shiffman, Mitchell, Siddique, Asma, Smith, Matthew, Suarez, Rosa, Talal, Andrew, Te, Helen, Tekola, Bezawit, Tetri, Brent, Thuluvath, Paul, Toro, Doris, Torres, Dawn, Trinh, Huy, Trotter, James, Vento, Angel, Vierling, John, Vuppalanchi, Raj, Waters, Michael, Weisberg, Ilan, Wieland, Amanda, Williams, Alonzo, Younes, Ziad, Adams, Leon, Harding, Damian, Hodge, Alex, Kontorinis, Nick, Strasser, Simone, Thompson, Alex, Horsmans, Yves, Steenkiste, Christophe Van, Bailey, Robert, Giard, Jeanne-Marie, Montano-Loza, Aldo, Puglia, Marco, Tsoi, Keith, Larrey, Dominique, Nguyen-Khac, Eric, Ratziu, Vlad, Spengler, Ulrich, Wiegand, Johannes, Hui, Aric Josun, Acharya, Subrat Kumar, Sarin, Shiv Kumar, Tantry, Vishwanath, Braun, Marius, Hazzan, Rawi, Lurie, Yoav, Colombo, Massimo, Fujii, Hideki, Hashimoto, Etsuko, Kato, Masaki, Ogawa, Koji, Takehara, Tetsuo, Tokushige, Katsutoshi, Garza, Laura Esthela Cisneros, Ladrón De Guevara, Alma Laura, Schultz, Michael, Janczewska, Ewa, Toro, Doris H., Jeong, Sook-Hyang, Kim, Yoon Jun, Lee, Jin-Woo, Ang, Tiing Leong, Bee, George Goh Boon, Benlloch, Salvador, Caballería, Juan, Calleja, José Luis, Rodríguez, Jose A. Carrión, Crespo, Javier, Diago, Moises, Fernandez-Rodriguez, Conrado, García-Samaniego, Javier, Ginès, Pere, Romero, Manuel, Dufour, Jean-François, Alazawi, William, Ch'ng, Chin-Lye, Forton, Daniel, Priest, Matthew, Sheridan, David, Ankoma-Sey, Victor, Balakrishnan, Maya, Bambha, Kiran, Barritt, A. Sidney, Bhandari, Bal, Brandman, Danielle, Chang, Charissa, Corey, Kathleen, Feldman, Michael, Gholam, Pierre, Goff, John, Marzio, Dina Halegoua-De, Harrison, Stephen, Hellstern, Paul, Jr., Herring, Robert, Iyer, Rajalakshmi, Jakiche, Antoine, Kohli, Anita, Krok, Karen, Kugelmas, Marcelo, Kumar, Sonal, Lai, Michelle, Mahmoud, Mitchell, Mantry, Parvez, Marsano, Luis, Nguyen, Tuan, Park, James, Patton, Heather M., Pockros, Paul, Reddy, Rajender, Rodriguez, Miguel, Sarles, Harry, Satapathy, Sanjaya, Sedghi, Shahriar, Shah, Nikunj, Sheikh, Muhammad Yasin, Sigal, Samuel, Stanca, Carmen, Steinbook, Michael, Szabo, Gyongyi, Terrault, Norah, Tong, Myron, Victor, David, Zervos, Xaralambos, Harrison, Stephen A., Wong, Vincent Wai-Sun, Caldwell, Stephen H., Shiffman, Mitchell L., Camargo, Marianne, Li, Georgia, Kersey, Kathryn, Jia, Catherine, Zhu, Yanni, Djedjos, C. Stephen, Subramanian, G. Mani, Myers, Robert P., Anstee, Quentin M., Romero-Gomez, Manuel, Goodman, Zachary, Lawitz, Eric J., and Younossi, Zobair

Published
2020
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11. Sofosbuvir–velpatasvir single-tablet regimen administered for 12 weeks in a phase 3 study with minimal monitoring in India

Author

Sood, Ajit, Duseja, Ajay, Kabrawala, Mayank, Amrose, Pradeep, Goswami, Bhadadev, Chowdhury, Abhijit, Sarin, Shiv Kumar, Koshy, Abraham, Hyland, Robert H., Lu, Sophia, Camus, Gregory, Stamm, Luisa M., Brainard, Diana M., Subramanian, G. Mani, Prasad, Madhura, Bhatia, Shobna, Shah, Samir R., Kapoor, Dharmesh, Shalimar, and Saraswat, Vivek

Published
2019
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12. LUTS Assessment

Author

Bray, Alison, primary, Cashman, Sophia, additional, Cotterill, Nikki, additional, Drake, Marcus, additional, Fode, Mikkel, additional, Gammie, Andrew, additional, Harding, Christopher, additional, Kapoor, Dharmesh, additional, Thiruchelvam, Nikesh, additional, Thomas, Laura, additional, and Uren, Alan D., additional

Published
2019
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14. Safety and Efficacy of Ledipasvir/Sofosbuvir in HCV genotype 1 infection and the combination of Sofosbuvir and Daclatasvir in HCV genotype 3 infection in India

Author

Birajdar, Amit Ravindra, primary, Dayal, Vishwa Mohan, additional, Sood, Ajit, additional, Kumar, Ramesh, additional, Kapoor, Dharmesh, additional, Behl, Dr Nitin, additional, Nachankar, Rajesh, additional, Hegde, Sanjeev, additional, Hadigal, Sanjay, additional, and Birajdar, Amit Ravindra, additional

Published
2023
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15. Chronic hepatitis C virus infection in India: Regional demographics and distribution of viral genotypes

Author

Shah, Samir R., Rao, P. N., Sarin, Shiv K., Chowdhury, Abhijit, Bhatia, Shobna, Dharamsi, Rajesh, Goswami, B. D., Kapoor, Dharmesh, Luaia, Rosang, Mehta, Rajiv, Mukewar, Shrikant, Prasad, V. G. Mohan, Rai, Ramesh Roop, Saigal, Sanjiv, Singh, Devendra, Trehanpati, Nirupama, Chen, Sandra, Gaggar, Anuj, Knox, Steven J., Subramanian, G. Mani, Singh, Shivaram Prasad, Sood, Ajit, Varghese, Joy, and Venugopal, Raj Vigna

Published
2016
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19. Effect of antifibrinolytic drugs on transfusion requirement and blood loss during orthotopic liver transplantation: Results from a single center

Author

Devi A, Kapoor Dharmesh, Gopal PBN, Subrahmanyam M, and Ravichandra R

Subjects
Antifibrinolytics, blood transfusion, fibrinolysis, liver transplantation, Diseases of the blood and blood-forming organs, RC633-647.5
Abstract

Background: During orthotopic liver transplantation (OLT), activation of the fibrinolytic system can contribute significantly to perioperative bleeding. Prophylactic administration of antifibrinolytic agents has been shown to reduce blood loss and the need for allogenic transfusion. Objective: To study the effect of antifibrinolytics on requirement of blood components, blood loss and operative time during OLT in patients with end stage liver disease, reporting to a single centre. Materials and Methods: Consecutive patients who underwent OLT at this centre during the period February 2003-October 2007 were the subjects of this study. Based on the individual anesthesiologist′s preference, patients were assigned to receive either two million units of aprotinin (AP) as a bolus followed by 5,00,000 units/hour or 10 mg/kg tranexamic acid (TA)as a bolus followed by 10 mg/kg every six to eight hours, administered from the induction till the end of the surgery. Transfusion policy was standardized in all patients. Intraoperative red cell salvage was done wherever possible. The effect of these two antifibrinolytic drugs on transfusion requirement was evaluated as a whole and in a sub group of patients from each treatment group and compared with a concurrent control group that did not receive antifibrinolytic drugs. Results: Fifty patients (40 M / 10 F, 44 adults, 6 pediatric patients) underwent OLT in the study period. Fourteen patients were given AP, 25 patients were given TA and 11 patients did not receive any of the agents(control group). The median volume of total blood components transfused in antifibrinolytic group (n=39) was 4540 ml(0-19,200ml), blood loss 5 l(0.7-35l) and operative time 9h (4.5-17h) and that of control group(n=11) was 5700 ml(0-15,500ml), 10 l(0.6-25 l) and 9h (6.4-15.8h) respectively. The median volume of blood transfusions, blood loss and operative time was lesser in AP group(n=14) than that of TA group(n=25). Conclusion: There is definite decrease in transfusion requirement, blood loss and operative time in the patients who received antifibrinolytic drugs than that of patients who did not receive. Because of the small sample size, comparisons carried between different groups did not show statistical significance. Prophylactic use of antifibrinolytics during OLT, possibly helps in blood conservation.

Published
2008

25. A Multicentric Experience on Living Donor Liver Transplantation in COVID‐19 Hotspots in India

Author

Varghese, Joy, Malleeswaran, Selvakumar, Patcha, Rajanikanth V., Appusamy, Ellango, Karnan, Perumal, Kapoor, Dharmesh, Kota, Venugopal, Kedarisetty, Chandhan Kumar, Singh, Balbir, Rao, Prashantha S., Yalakanti, Raghavendra Babu, Mohanka, Ravi, Shrimal, Anurag, Nikam, Vinayak, Kumar, Karan, Shenvi, Sunil D., Pillai, Venugopal Bhaskaran, and Heaton, Nigel D.

Subjects
liver transplant, Tissue and Organ Procurement, Rapid Communication and Brief Report, SARS-CoV-2, Living Donors, chronic liver disease, COVID-19, Humans, India, LDLT, SARS‐CoV‐2, Liver Transplantation
Abstract

As of August 2020, severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) has affected more than 213 countries, leading to more than 18 million cases and 690,000 deaths. India is the second most affected country, with the majority of cases in metropolitan cities, such as Mumbai, New Delhi, Chennai, and Bengaluru. There is limited literature on the outcomes and safety of performing living donor liver transplantation (LDLT) in coronavirus disease 2019 (COVID‐19) epicenters.

Published
2020

26. International Consultation on Incontinence Questionnaire‐Satisfaction:psychometric testing of a new patient‐reported outcome measure for the evaluation of satisfaction after urological surgery

Author

Uren, Alan D, Cotterill, Nikki, Hashim, Hashim, Worthington, Jo M, Kapoor, Dharmesh, and Abrams, Paul H

Subjects
UNBLOCS
Abstract

ObjectivesTo evaluate the psychometric properties of a new patient‐reported outcome measure (PROM), the International Consultation on Incontinence Questionnaire‐Satisfaction (ICIQ‐S), to assess satisfaction after urological surgery. Subjects/Patients and MethodsFollowing item development, the developmental ICIQ‐S (dICIQ‐S) was used within in a randomised control trial comparing two types of surgery for male prostatic obstruction at 1.5, 3, and 12 months after surgery. Reliability was assessed by Cronbach’s α and construct validity by the correlation of scores with concurrently administered PROMs of known validity: ICIQ‐Male Lower Urinary Tract Symptoms (LUTS), International Prostate Symptom Score, and the ICIQ‐LUTS Quality of Life.ResultsA total of 410 men were included in the trial. Missing data was generally low for the dICIQ‐S [mean (range) 1.6 (ConclusionThe results support the validity and reliability of a scored six‐item domain for evaluating satisfaction with surgical outcomes, together with a standalone scored overall satisfaction item. The further unscored seven standalone items are anticipated to be used as the basis for adaptation and further validation of the ICIQ‐S in different patient populations.

Published
2020

27. International Consultation on Incontinence Questionnaire-Satisfaction: psychometric testing of a new patient-reported outcome measure for the evaluation of satisfaction after urological surgery

Author

Cotterill, Nikki, Hashim, Hashim, Worthington, Jo, Kapoor, Dharmesh, Abrams, Paul, and Uren, Alan D.

Subjects
Satisfaction, urology, surgery, patient reported outcome, Health, Health & Wellbeing, Centre for Health and Clinical Research
Abstract

Objectives: To evaluate the psychometric properties of a new patient-reported outcome measure (PROM), the International Consultation on Incontinence Questionnaire-Satisfaction (ICIQ-S), to assess satisfaction after urological surgery. Subjects/Patients and Methods: Following item development, the developmental ICIQ-S (dICIQ-S) was used within in a randomised control trial comparing two types of surgery for male prostatic obstruction at 1.5, 3, and 12months after surgery. Reliability was assessed by Cronbach’s α and construct validity by the correlation of scores with concurrently administered PROMs of known validity: ICIQ-Male Lower Urinary Tract Symptoms (LUTS), International Prostate Symptom Score, and the ICIQ-LUTS Quality of Life. Results: A total of 410 men were included in the trial. Missing data was generally low for the dICIQ-S [mean (range) 1.6(

Published
2020

29. A Multicentric Experience on Living Donor Liver Transplantation in Coronavirus Disease 2019 Hotspots in India

Author

Varghese, Joy, primary, Malleeswaran, Selvakumar, additional, Patcha, Rajanikanth V., additional, Appusamy, Ellango, additional, Karnan, Perumal, additional, Kapoor, Dharmesh, additional, Venugopal, Kota, additional, Kedarisetty, Chandhan Kumar, additional, Singh, Balbir, additional, Rao, Prashantha S., additional, Yalakanti, Raghavendra Babu, additional, Mohanka, Ravi, additional, Shrimal, Anurag, additional, Nikam, Vinayak, additional, Kumar, Karan, additional, Shenvi, Sunil D., additional, Venugopal, Bhaskaran Pillai, additional, and Heaton, Nigel D., additional

Published
2021
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37. Identification of 19 novel hepatitis C virus subtypes—further expanding HCV classification

Author

Hedskog, Charlotte, Parhy, Bandita, Chang, Silvia, Zeuzem, Stefan, Moreno, Christophe, Shafran, Stephen D., Borgia, Sergio M., Asselah, Tarik, Alric, Laurent, Abergel, Armand, Chen, Jyh-Jou, Collier, Jane, Kapoor, Dharmesh, Hyland, Robert, Simmonds, Peter, Mo, Hongmei, Svarovskaia, Evguenia S., Hedskog, Charlotte, Parhy, Bandita, Chang, Silvia, Zeuzem, Stefan, Moreno, Christophe, Shafran, Stephen D., Borgia, Sergio M., Asselah, Tarik, Alric, Laurent, Abergel, Armand, Chen, Jyh-Jou, Collier, Jane, Kapoor, Dharmesh, Hyland, Robert, Simmonds, Peter, Mo, Hongmei, and Svarovskaia, Evguenia S.

Abstract

Background: Hepatitis C virus (HCV) is currently classified into 8 genotypes and 86 subtypes. The objective of this study was to characterize novel HCV subtypes and to investigate the impact of subtypes on treatment outcome. Methods: Full-genome sequencing was performed on HCV plasma samples with <85% sequence homology of NS3, NS5A, and/or NS5B to HCV genotype (GT) 1–8 reference strains. Results: A total of 14 653 patients with GT1–6 HCV infection were enrolled in clinical studies of sofosbuvir-based regimens. For the majority of the patients, a specific subtype could be assigned based on a close genetic relationship to previously described subtypes. However, for 19 patients, novel subtypes were identified with <85% homology compared with previously described subtypes. These novel subtypes had the following genotypes: 9 in GT2, 5 in GT4, 2 in GT6, and 1 each in GT1, GT3, and GT5. Despite the presence of polymorphisms at resistance-associated substitution positions, 18 of the 19 patients treated with sofosbuvir-containing therapy achieved SVR12. Conclusions: Nineteen novel HCV subtypes were identified, suggesting an even greater genetic diversity of HCV subtypes than previously recognized.

Published
2019

39. Portal biliopathy

Author

Chandra, Ramesh, Kapoor, Dharmesh, Tharakan, Ajith, Chaudhary, Adarsh, and Sarin, Shiv Kumar

Published
2001

40. Erratum to ‘Indian National Association for the Study of Liver Consensus Statement on Acute Liver Failure (Part-2): Management of Acute Liver Failure’ [J Clin Exp Hepatol 10 (2020) 477-517]

Author

Anand, Anil C., Nandi, Bhaskar, Acharya, Subrat K., Arora, Anil, Babu, Sethu, Batra, Yogesh, Chawla, Yogesh K., Chowdhury, Abhijit, Chaoudhuri, Ashok, Eapen, Eapen C., Devarbhavi, Harshad, Dhiman, Radha K., Datta Gupta, Siddhartha, Duseja, Ajay, Jothimani, Dinesh, Kapoor, Dharmesh, Kar, Premashish, Khuroo, Mohamad S., Kumar, Ashish, Madan, Kaushal, Mallick, Bipadabhanjan, Maiwall, Rakhi, Mohan, Neelam, Nagral, Aabha, Nath, Preetam, Panigrahi, Sarat C., Pawar, Ankush, Philips, Cyriac A., Prahraj, Dibyalochan, Puri, Pankaj, Rastogi, Amit, Saraswat, Vivek A., Saigal, Sanjiv, Shalimar, Shukla, Akash, Singh, Shivaram P., Verghese, Thomas, and Wadhawan, Manav

Published
2022
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44. Consensus statement on the management of invasive candidiasis in Indian scenario

Author

Shastri, Prakash, primary, Nangia, Vivek, additional, Sathe, Prachee, additional, Pande, Rajesh, additional, Abraham, Abi, additional, Hegde, Ashit, additional, Ansari, Abdul Samad, additional, Kapoor, Dharmesh, additional, Mandal, Amit, additional, Jain, Alok, additional, Dinaker, M., additional, Mohanty, Deepali, additional, Das, Dimbeshwar, additional, Kola, Venkat Ramana, additional, Sinha, Sharmili, additional, Mohanty, Amitav, additional, and Girn, Hardev Singh, additional

Published
2019
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46. Identification of 19 Novel Hepatitis C Virus Subtypes—Further Expanding HCV Classification

Author

Hedskog, Charlotte, primary, Parhy, Bandita, additional, Chang, Silvia, additional, Zeuzem, Stefan, additional, Moreno, Christophe, additional, Shafran, Stephen D, additional, Borgia, Sergio M, additional, Asselah, Tarik, additional, Alric, Laurent, additional, Abergel, Armand, additional, Chen, Jyh-Jou, additional, Collier, Jane, additional, Kapoor, Dharmesh, additional, Hyland, Robert H, additional, Simmonds, Peter, additional, Mo, Hongmei, additional, and Svarovskaia, Evguenia S, additional

Published
2019
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48. Study of Cardiovascular Risk Assessment in Patients with Fatty Liver Disease.

Author

Shinde, Prashant Satwaji, Kawale, Suchita Narayan, and Kapoor, Dharmesh

Subjects
FATTY liver, CARDIOVASCULAR diseases risk factors, RISK assessment, WAIST circumference, LIVER diseases
Abstract

Background- The term ‘fatty liver disease’ (FLD) is used to describe a variety of liver diseases of different severity, from pure steatosis to steatohepatitis and cirrhosis and hepatocellular carcinoma. Objective- To Study Of Cardiovascular Risk Assessment In Patients With Fatty Liver Disease. Methodology- This prospective single center study was conducted from 1st March 2015 to 1st March 2016, in the Department of Gastroenterology in collaboration with Department of Community medicine at Global hospitals. All Adult (18 years to 70 years) patients, both sexes, reporting to Medical Gastroenterology with FLD were included in the study which were 32.Result - Maximum 28 subjects (87.5 %) were male while 4(12.5%) were female. Male to female ratio was 7:1. Maximum patients 20(62.5%) belonged to Grade II fatty liver followed by 09 (28.12%) Grade I and 03(9.3%) Grade III. 11(34.37%) were overweight,17 (53.12%) were obese,only 4 patients had normal BMI. 27(96.42%) out of 28 male patients had abnormal waist while four (100%) out of 4 female patients had abnormal waist circumference. 12(37.50) Patients with FLD had significantly higher levels of total cholesterol.Conclusion- . FLD may serve as a trigger for assessment of cardiovascular risk factors, and such patients should undergo further cardiovascular assessment. [ABSTRACT FROM AUTHOR]

Published
2020
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49. Critical care issues in adult liver transplantation

Author

Gopal, Palepu, Kapoor, Dharmesh, Raya, Ravichandra, Subrahmanyam, M., Juneja, Deven, and Sukanya, B.

Subjects
Company business management, Immunosuppressive agents -- Health aspects, Immunosuppressive agents -- Usage, Liver diseases -- Care and treatment, Critical care medicine -- Management, Liver -- Transplantation, Liver -- Management
Abstract

Byline: Palepu. Gopal, Dharmesh. Kapoor, Ravichandra. Raya, M. Subrahmanyam, Deven. Juneja, B. Sukanya Over the last decade, liver transplantation has become an operational reality in our part of the world. [...]

Published
2009

50. Two Cases of Nocardiabacteraemia in Solid Organ Transplant Recipients

Author

Iyer, Ranganathan N., Rao, Jangam Rekha, Rudramurthy, Shivaprakash M., and Kapoor, Dharmesh

Abstract

Nocardiosis is an opportunistic infection occurring in immunosuppressed patients. While disseminated nocardiosis is common in immunosuppressed patients, Nocardiabacteraemia is rare. There are few reports of Nocardiabacteraemia following solid organ transplantation. We report two cases of Nocardiabacteraemia in solid organ transplant recipients-Nocardia cyriacigeorgicabacteraemia in liver transplant recipient and concomitant Nocardia farcinicabacteraemia and cyclosporiasis in a heart transplant recipient. Prompt recognition of early bacteraemia with initiation of antibiotic therapy may avoid the complications of disseminated disease in the solid organ transplant recipients.

Published
2020
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