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20 results on '"Kaplon, Richard J"'

12. Partial Left Ventriculectomy.

Author

Masters, Roy G., Kaplon, Richard J., and McCarthy, Patrick M.

Abstract

End-stage heart failure currently affects 1 % of people under 55 years old, 9% of people over 80 years old, and is expected to continue to increase in prevalence.1 Despite improvements in pharmacologic management of heart failure with newer agents such as angiotensin-converting enzyme inhibitors or beta-blockers such as carvedilol, approximately 25% of patients die while awaiting heart transplantation. 2-4 Even with attempts at expanding the donor pool through "alternate recipient lists", the limited number of hearts available for transplantation has plateaued.5,6 Ventricular-assist devices (VAD) have been effective as bridges to transplantation for those patients refractory to medical therapy, however, present use of VADs as destination therapy remains investigational.7-9 Clinical attempts at cardiomyoplasty and xenotransplantation have, thus far, been generally disappointing.10,11 [ABSTRACT FROM AUTHOR]

Published
2000
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13. SHORT COURSE SINGLE AGENT THERAPY WITH AN LFA-3-IgG1 FUSION PROTEIN PROLONGS PRIMATE CARDIAC ALLOGRAFT SURVIVAL1,2

Author

Kaplon, Richard J., primary, Hochman, Paula S., additional, Michler, Robert E., additional, Kwiatkowski, Pawel A., additional, Edwards, Niloo M., additional, Berger, Carole L., additional, Xu, He, additional, Meier, Werner, additional, Wallner, Barbara P., additional, Chisholm, Patricia, additional, and Marboe, Charles C., additional

Published
1996
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14. Discriminating Between Preservation and Reperfusion Injury in Human Cardiac Allografts Using Heart Weight and Left Ventricular Mass

Author

Slater, James P., primary, Amirhamzeh, Mehrdad M.R., additional, Yano, Osvaldo J., additional, Shah, Aamir S., additional, Starr, Joanne P., additional, Kaplon, Richard J., additional, Burfeind, William, additional, Pepino, Paolo, additional, Michler, Robert E., additional, Rose, Eric A., additional, Smith, Craig R., additional, Spotnitz, Henry M., additional, and Oz, Mehmet C., additional

Published
1995
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20. ABSENCE OF HYPERACUTE REJECTION IN PIGTO-PRIMATE ORTHOTOPIC PULMONARY XENOGRAFTS

Author

KAPLON, RICHARD J., PLATT, JEFFREY L., KWIATKOWSKI, PAWEL A., EDWARDS, NILOO M., XU, H E, SHAH, AAMIR S., MASROOR, SAQIB, and MICHLER, ROBERT E.

Abstract

The shortage of organ donors for transplantation is more pronounced for the lung than for any other solid organ. To address this problem, we evaluated the feasibility of pulmonary xenotransplantation. Preliminary investigations demonstrated that orthotopically placed pig lungs in cynomologous monkey recipients could be engrafted up to 9 hr after reperfusion without evidence of hyperacute rejection. In this study, the rejection reaction of pig lungs transplanted orthotopically into baboons (n=6) was further investigated by ELISA and immunohistochemistry. Four baboon recipients were killed at 24 hr and 2 recipients were killed at 72 hr after transplantation. Pulmonary arterial flow measurements demonstrated flow to the grafts, and systemic arterial and xenograft pulmonary venous blood gas analysis suggested function of the donor lungs during the course of engraftment. Serum levels of baboon anti-pig endothelial cell xenoanti-body were normal and decreased minimally over time. Immunohistochemical staining of biopsies demonstrated trace IgG and IgM along graft endothelium 2 hr after reperfusion. At 8 hr, biopsy samples showed no immunoglobulin bound to endothelial cells. Staining for complement was negative. Fibrin and platelets were detected along xenograft endothelium. Despite these findings, the lung xenografts appeared injured and clinically rejected. During the first 8 hr after reperfusion, the grafts were hyperemic and subsequently became focally ecchymotic. Chest x-rays showed progressive pulmonary congestion. These findings suggest that the lung may be relatively resistant to antibody-mediated hyperacute rejection and efforts are being directed toward identifying the mechanism of the observed xenograft lung injury.

Published
1995

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