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6. Management of Gestational Diabetes Mellitus

Author

Oskovi-Kaplan, Z. Asli, Ozgu-Erdinc, A. Seval, Crusio, Wim E., Series Editor, Dong, Haidong, Series Editor, Radeke, Heinfried H., Series Editor, Rezaei, Nima, Series Editor, Xiao, Junjie, Series Editor, and Islam, Md. Shahidul, editor

Published
2021
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11. Regional disparities in the use of intensive chemotherapy for AML in the Netherlands: Does it influence survival?

Author

MS Hematologie, Cancer, Kaplan, Z. L.Rana, Van Leeuwen, Nikki, Van Klaveren, David, Visser, Otto, Posthuma, Eduardus F.M., Van Lammeren-Venema, Danielle, Snijders, Tjeerd J.F., Van Elssen, Catharina H.M.J., Van Rhenen, Anna, Von Dem Borne, Peter A., Blijlevens, Nicole M.A., Cornelissen, Jan J., Raaijmakers, Marc H.G.P., Van De Loosdrecht, Arjan A., Huls, Gerwin, Lemmens, Valery E.P.P., Lingsma, Hester F., Dinmohamed, Avinash G., MS Hematologie, Cancer, Kaplan, Z. L.Rana, Van Leeuwen, Nikki, Van Klaveren, David, Visser, Otto, Posthuma, Eduardus F.M., Van Lammeren-Venema, Danielle, Snijders, Tjeerd J.F., Van Elssen, Catharina H.M.J., Van Rhenen, Anna, Von Dem Borne, Peter A., Blijlevens, Nicole M.A., Cornelissen, Jan J., Raaijmakers, Marc H.G.P., Van De Loosdrecht, Arjan A., Huls, Gerwin, Lemmens, Valery E.P.P., Lingsma, Hester F., and Dinmohamed, Avinash G.

Published
2024

12. Regional disparities in the use of intensive chemotherapy for AML in the Netherlands:Does it influence survival?

Author

Kaplan, Z. L.Rana, Van Leeuwen, Nikki, Van Klaveren, David, Visser, Otto, Posthuma, Eduardus F.M., Van Lammeren-Venema, Danielle, Snijders, Tjeerd J.F., Van Elssen, Catharina H.M.J., Van Rhenen, Anna, Von Dem Borne, Peter A., Blijlevens, Nicole M.A., Cornelissen, Jan J., Raaijmakers, Marc H.G.P., Van De Loosdrecht, Arjan A., Huls, Gerwin, Lemmens, Valery E.P.P., Lingsma, Hester F., Dinmohamed, Avinash G., Kaplan, Z. L.Rana, Van Leeuwen, Nikki, Van Klaveren, David, Visser, Otto, Posthuma, Eduardus F.M., Van Lammeren-Venema, Danielle, Snijders, Tjeerd J.F., Van Elssen, Catharina H.M.J., Van Rhenen, Anna, Von Dem Borne, Peter A., Blijlevens, Nicole M.A., Cornelissen, Jan J., Raaijmakers, Marc H.G.P., Van De Loosdrecht, Arjan A., Huls, Gerwin, Lemmens, Valery E.P.P., Lingsma, Hester F., and Dinmohamed, Avinash G.

Abstract

Objective Acute myeloid leukaemia (AML) prognosis is enhanced with intensive remission induction chemotherapy (ICT) in eligible patients. However, ICT eligibility perceptions may differ among healthcare professionals. This nationwide, population-based study aimed to explore regional variation in ICT application and its relation with overall survival (OS). Methods and analysis We compared nine Dutch regional networks using data from the Netherlands Cancer Registry. Regional variance was assessed for the entire population and age subgroups (ie, ≤60 years and >60 years) using multivariable mixed effects logistic and Cox proportional hazard regression analyses, expressed via median OR (MOR) and median HR (MHR). Results Including all adult AML patients from 2014 to 2018 (N=4060 patients; 58% males; median age, 70 years), 1761 (43%) received ICT. ICT application varied from 36% to 57% (MOR 1.36 (95% CI 1.11 to 1.58)) across regions, with minor variations for patients aged ≤60 years (MOR 1.16 (95% CI 1.00 to 1.40)) and more extensive differences for those aged >60 years (MOR 1.43 (95% CI 1.16 to 1.63)). Median OS spanned 4.9-8.4 months across regions (MHR 1.11 (95% CI 1.00 to 1.15)), with pronounced differences in older patients (MHR 1.12 (95% CI 1.08 to 1.20)) but negligible differences in the younger group (MHR 1.02 (95% CI 1.00 to 1.14)). Survival differences for the total population and the older patients decreased to respectively, MHR 1.09 (95% CI 1.00 to 1.13) and 1.10 (95% CI 1.04 to 1.18), after additional adjustment for the probability of receiving ICT within a region, indicating approximately 10% unexplained differences. Conclusion Regional disparities in ICT application and survival exist, especially in older AML patients. However, ICT application differences partially explain survival disparities, indicating the need for more standardised ICT eligibility criteria and a better understanding of underlying causes of outcome disparities.

Published
2024

13. Health-related quality of life (HRQoL) after different axillary treatments in women with breast cancer:a 1-year longitudinal cohort study

Author

Vrancken Peeters, N. J.M.C., Kaplan, Z. L.R., Clarijs, M. E., Mureau, M. A.M., Verhoef, C., van Dalen, T., Husson, O., Koppert, L. B., Vrancken Peeters, N. J.M.C., Kaplan, Z. L.R., Clarijs, M. E., Mureau, M. A.M., Verhoef, C., van Dalen, T., Husson, O., and Koppert, L. B.

Abstract

Purpose: As life expectancy continues to rise, post-treatment health-related quality of life (HRQoL) of breast cancer patients becomes increasingly important. This study examined the one-year longitudinal relation between axillary treatments and physical, psychosocial, and sexual wellbeing and arm symptoms. Methods: Women diagnosed with breast cancer who received different axillary treatments being axilla preserving surgery (APS) with or without axillary radiotherapy or full axillary lymph node dissection (ALND) with or without axillary radiotherapy were included. HRQoL was assessed at baseline, 6- and 12-months postoperatively using the BREAST-Q and the European Organization for Research and Treatment of Cancer QoL Questionnaire Breast Cancer Module (EORTC QLQ-BR23). Mixed regression models were constructed to assess the impact of axillary treatment on HRQoL. HRQoL at baseline was compared to HRQoL at 6- and at 12-months postoperatively. Results: In total, 552 patients were included in the mixed regressions models. Except for ALND with axillary radiotherapy, no significant differences in physical and psychosocial wellbeing were found. Physical wellbeing decreased significantly between baseline and 6- and 12-months postoperatively (p < 0.001, p = 0.035) and psychosocial wellbeing decreased significantly between baseline and 12 months postoperatively (p = 0.028) for ALND with axillary radiotherapy compared to APS alone. Arm symptoms increased significantly between baseline and 6 months and between baseline and 12 months postoperatively for APS with radiotherapy (12.71, 13.73) and for ALND with radiotherapy (13.93, 16.14), with the lowest increase in arm symptoms for ALND without radiotherapy (6.85, 7.66), compared to APS alone (p < 0.05). Conclusion: Physical and psychosocial wellbeing decreased significantly for ALND with radiotherapy compared to APS alone. Shared decision making a

Published
2024

18. OC 65.1 Long-Term Efficacy and Safety with Oral Bruton Tyrosine Kinase Inhibitor Rilzabrutinib in Patients with Immune Thrombocytopenia

Author

Kuter, D., primary, Efraim, M., additional, Kaplan, Z., additional, Mayer, J., additional, Choi, P., additional, Jansen, G.A.J., additional, McDonald, V., additional, Baker, R., additional, Bird, R., additional, Garg, M., additional, Gumulec, J., additional, Košťál, M., additional, Gernsheimer, T., additional, Ghanima, W., additional, Khan, U., additional, Daak, A., additional, and Cooper, N., additional

Published
2023
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19. Health care utilization and outcomes in older adults after Traumatic Brain Injury: A CENTER-TBI study

Author

van der Vlegel, Marjolein, Mikolić, Ana, Wilson, Lindsay, Gomez, Pedro A., Lagares, Alfonso, Chevallard, Giorgio, Chieregato, Arturo, Citerio, Giuseppe, Vargiolu, Alessia, Ceyisakar, Iris, Gravesteijn, Benjamin, Haagsma, Juanita A., Huijben, Jilske, Maas, Andrew I. R., Lingsma, Hester, Nieboer, Daan, Mikolic, Ana, Polinder, Suzanne, Sewalt, Charlie, Steyerberg, Ewout W., Velt, Kimberley, Voormolen, Daphne, Wiegers, Eveline, Peul, Wilco, van Dijck, Jeroen T. J. M., van Essen, Thomas A., van Wijk, Roel P. J., Clusmann, Hans, Coburn, Mark, Kowark, Ana, Rossaint, Rolf, Coles, Jonathan, Cooper, Jamie D., Correia, Marta, Čovid, Amra, von Steinbüchel, Nicole, Curry, Nicola, Stanworth, Simon, Dahyot-Fizelier, Claire, Dark, Paul, Johnson, Faye, Dawes, Helen, Esser, Patrick, van Heugten, Caroline, CENTER-TBI Participants and Investigators, De Keyser, Véronique, Menovsky, Tomas, Van der Steen, Gregory, Della Corte, Francesco, Grossi, Francesca, Depreitere, Bart, Đilvesi, Đula, Golubovic, Jagoš, Karan, Mladen, Åkerlund, Cecilia, Vulekovic, Petar, Dreier, Jens, Vajkoczy, Peter, Wolf, Stefan, Dulière, Guy-Loup, Maréchal, Hugues, Fabricius, Martin, Kondziella, Daniel, Feigin, Valery L., Jones, Kelly, George, Pradeep, Ao, Braden Te, Theadom, Alice, Foks, Kelly, Haitsma, Iain, Volovici, Victor, Furmanov, Alex, Rosenthal, Guy, Gagliardo, Pablo, Gao, Guoyi, Jiang, Ji-yao, Lanyon, Linda, Ghuysen, Alexandre, Giga, Lelde, Valeinis, Egils, Ziverte, Agate, Glocker, Ben, Rueckert, Daniel, Gratz, Johannes, Gruen, Russell L., Gupta, Deepak, Roe, Cecilie, Muraleedharan, Visakh, Helseth, Eirik, Roise, Olav, Horton, Lindsay, Hutchinson, Peter J., Kolias, Angelos G., Jacobs, Bram, van der Naalt, Joukje, Jankowski, Stefan, Kompanje, Erwin, Nelson, David, Timmers, Marjolein, Laureys, Steven, Ledoux, Didier, Misset, Benoit, Lecky, Fiona, Olubukola, Otesile, Lefering, Rolf, Schäfer, Nadine, Legrand, Valerie, Lejeune, Aurelie, Lee Hee, Quentin, Amrein, Krisztina, Vega, Emmanuel, Mattern, Julia, Levi, Leon, Lightfoot, Roger, Maegele, Marc, Manara, Alex, Thomas, Matt, Manley, Geoffrey, Martino, Costanza, Sakowitz, Oliver, Ezer, Erzsébet, Sanchez-Porras, Renan, Younsi, Alexander, McMahon, Catherine, Negru, Ancuta, Oresic, Matej, Palotie, Aarno, Parizel, Paul M., Payen, Jean-François, Persona, Paolo, Piippo-Karjalainen, Anna, Kovács, Noémi, Pirinen, Matti, Ples, Horia, Posti, Jussi P., Puybasset, Louis, Radoi, Andreea, Ragauskas, Arminas, Raj, Rahul, Rambadagalla, Malinka, Rhodes, Jonathan, Richardson, Sylvia, Melegh, Béla, Ripatti, Samuli, Rocka, Saulius, Rosand, Jonathan, Rosenfeld, Jeffrey V., Rossi, Sandra, Rusnák, Martin, Sahuquillo, Juan, Sandor, Janos, Schmidt, Silke, Schoechl, Herbert, Nyirádi, József, Schoonman, Guus, Skandsen, Toril, Stevens, Robert, Stewart, William, Takala, Riikka, Tamosuitis, Tomas, Tenovuo, Olli, Tibboel, Dick, Tolias, Christos, Tudora, Cristina Maria, Tamás, Viktória, van der Jagt, Mathieu, Van Hecke, Wim, Van Praag, Dominique, Vyvere, Thijs Vande, Verheyden, Jan, Vespa, Paul M., Vik, Anne, Vilcinis, Rimantas, Wang, Kevin K. W., Yang, Zhihui, Vámos, Zoltán, Ylén, Peter, Sorinola, Abayomi, Andelic, Nada, Andreassen, Lasse, Kaplan, Z. L. Rana, Anke, Audny, Frisvold, Shirin, Antoni, Anna, Schwendenwein, Elisabeth, Audibert, Gérard, Azouvi, Philippe, Azzolini, Maria Luisa, Beretta, Luigi, Calvi, Maria Rosa, Bartels, Ronald, Retel Helmrich, Isabel R. A., Boogert, Hugo den, Barzó, Pál, Beauvais, Romuald, Perera, Natascha, Beer, Ronny, Helbok, Raimund, Bellander, Bo-Michael, Belli, Antonio, Benali, Habib, Degos, Vincent, van Veen, Ernest, Galanaud, Damien, Perlbarg, Vincent, Berardino, Maurizio, Cavallo, Simona, Blaabjerg, Morten, Rosenlund, Christina, Schou, Rico Frederik, Bragge, Peter, Brazinova, Alexandra, Majdan, Marek, Taylor, Mark Steven, Zelinkova, Veronika, Brinck, Vibeke, Jarrett, Mike, Brooker, Joanne, Donoghue, Emma, Synnot, Anneliese, Brorsson, Camilla, Koskinen, Lars-Owe, Sundström, Nina, Steinbuechel, Nicole V., Buki, Andras, Czeiter, Endre, Bullinger, Monika, Cabeleira, Manuel, Czosnyka, Marek, Dixit, Abhishek, Ercole, Ari, Koraropoulos, Evgenios, Menon, David, Newcombe, Virginia, Plass, Anne Marie, Richter, Sophie, Smielewski, Peter, Stamatakis, Emmanuel, Williams, Guy, Winzeck, Stefan, Zeiler, Frederick A., Caccioppola, Alessio, Calappi, Emiliana, Carbonara, Marco, Ortolano, Fabrizio, Zeldovich, Marina, Zoerle, Tommaso, Stocchetti, Nino, Cameron, Peter, Gantner, Dashiell, Murray, Lynnette, Trapani, Tony, Vallance, Shirley, Lozano, Guillermo Carbayo, Pomposo, Inigo, Castaño-León, Ana M., Molecular Neuroscience and Ageing Research (MOLAR), CENTER-TBI Participants and Investigators, van der Vlegel, M, Mikolić, A, Hee, Q, Kaplan, Z, Helmrich, I, van Veen, E, Andelic, N, Steinbuechel, N, Plass, A, Zeldovich, M, Wilson, L, Maas, A, Haagsma, J, Polinder, S, Åkerlund, C, George, P, Lanyon, L, Muraleedharan, V, Nelson, D, Amrein, K, Ezer, E, Kovács, N, Melegh, B, Nyirádi, J, Tamás, V, Vámos, Z, Sorinola, A, Andreassen, L, Anke, A, Frisvold, S, Antoni, A, Schwendenwein, E, Audibert, G, Azouvi, P, Azzolini, M, Beretta, L, Calvi, M, Bartels, R, Boogert, H, Barzó, P, Beauvais, R, Perera, N, Beer, R, Helbok, R, Bellander, B, Belli, A, Benali, H, Degos, V, Galanaud, D, Perlbarg, V, Berardino, M, Cavallo, S, Blaabjerg, M, Rosenlund, C, Schou, R, Bragge, P, Brazinova, A, Majdan, M, Taylor, M, Zelinkova, V, Brinck, V, Jarrett, M, Brooker, J, Donoghue, E, Synnot, A, Brorsson, C, Koskinen, L, Sundström, N, Buki, A, Czeiter, E, Bullinger, M, Cabeleira, M, Czosnyka, M, Dixit, A, Ercole, A, Koraropoulos, E, Menon, D, Newcombe, V, Richter, S, Smielewski, P, Stamatakis, E, Williams, G, Winzeck, S, Zeiler, F, Caccioppola, A, Calappi, E, Carbonara, M, Ortolano, F, Zoerle, T, Stocchetti, N, Cameron, P, Gantner, D, Murray, L, Trapani, T, Vallance, S, Lozano, G, Pomposo, I, Castaño-León, A, Gomez, P, Lagares, A, Chevallard, G, Chieregato, A, Citerio, G, Vargiolu, A, Ceyisakar, I, Gravesteijn, B, Huijben, J, Lingsma, H, Nieboer, D, Mikolic, A, Sewalt, C, Steyerberg, E, Velt, K, Voormolen, D, Wiegers, E, Peul, W, van Dijck, J, van Essen, T, van Wijk, R, Clusmann, H, Coburn, M, Kowark, A, Rossaint, R, Coles, J, Cooper, J, Correia, M, Čovid, A, von Steinbüchel, N, Curry, N, Stanworth, S, Dahyot-Fizelier, C, Dark, P, Johnson, F, Dawes, H, Esser, P, van Heugten, C, De Keyser, V, Menovsky, T, Van der Steen, G, Corte, F, Grossi, F, Depreitere, B, Đilvesi, Đ, Golubovic, J, Karan, M, Vulekovic, P, Dreier, J, Vajkoczy, P, Wolf, S, Dulière, G, Maréchal, H, Fabricius, M, Kondziella, D, Feigin, V, Jones, K, Ao, B, Theadom, A, Foks, K, Haitsma, I, Volovici, V, Furmanov, A, Rosenthal, G, Gagliardo, P, Gao, G, Jiang, J, Ghuysen, A, Giga, L, Valeinis, E, Ziverte, A, Glocker, B, Rueckert, D, Gratz, J, Gruen, R, Gupta, D, Roe, C, Helseth, E, Roise, O, Horton, L, Hutchinson, P, Kolias, A, Jacobs, B, van der Naalt, J, Jankowski, S, Kompanje, E, Timmers, M, Laureys, S, Ledoux, D, Misset, B, Lecky, F, Olubukola, O, Lefering, R, Schäfer, N, Legrand, V, Lejeune, A, Vega, E, Mattern, J, Levi, L, Lightfoot, R, Maegele, M, Manara, A, Thomas, M, Manley, G, Martino, C, Sakowitz, O, Sanchez-Porras, R, Younsi, A, Mcmahon, C, Negru, A, Oresic, M, Palotie, A, Parizel, P, Payen, J, Persona, P, Piippo-Karjalainen, A, Pirinen, M, Ples, H, Posti, J, Puybasset, L, Radoi, A, Ragauskas, A, Raj, R, Rambadagalla, M, Rhodes, J, Richardson, S, Ripatti, S, Rocka, S, Rosand, J, Rosenfeld, J, Rossi, S, Rusnák, M, Sahuquillo, J, Sandor, J, Schmidt, S, Schoechl, H, Schoonman, G, Skandsen, T, Stevens, R, Stewart, W, Takala, R, Tamosuitis, T, Tenovuo, O, Tibboel, D, Tolias, C, Tudora, C, van der Jagt, M, Van Hecke, W, Van Praag, D, Vyvere, T, Verheyden, J, Vespa, P, Vik, A, Vilcinis, R, Wang, K, Yang, Z, Ylén, P, Public Health, Otorhinolaryngology and Head and Neck Surgery, Intensive Care, Neurology, Neurosurgery, Pediatric Surgery, University of Helsinki, Institute for Molecular Medicine Finland, Centre of Excellence in Complex Disease Genetics, Aarno Palotie / Principal Investigator, Genomics of Neurological and Neuropsychiatric Disorders, HUS Neurocenter, Department of Mathematics and Statistics, Helsinki Institute for Information Technology, Statistical and population genetics, Clinicum, Helsinki University Hospital Area, Neurokirurgian yksikkö, Faculty Common Matters (Faculty of Social Sciences), Department of Public Health, Samuli Olli Ripatti / Principal Investigator, and Complex Disease Genetics

Subjects
Traumatic, Quality of Life/psychology, Traumatic Brain Injury, Health-related quality of life, Health care utilization, 3112 Neurosciences, Glasgow Outcome Scale, Outcomes, Patient Acceptance of Health Care, SDG 3 - Good Health and Well-being, Older adults, Brain Injuries, Brain Injuries, Traumatic, Quality of Life, Humans, General Earth and Planetary Sciences, Mental health, 3111 Biomedicine, Prospective Studies, Human medicine, Older adult, Aged, Outcome, General Environmental Science
Abstract

Injury : international journal of the care of the injured 53(8), 2774-2782 (2022). doi:10.1016/j.injury.2022.05.009, Published by Elsevier Science, Amsterdam [u.a.]

Published
2022

21. Neonatal Antibodies are Detected in Cord Blood After Vaccination of Pregnant Woman with the Inactivated SARS-CoV-2 Vaccine: A Case Report.

Author

OSKOVİ-KAPLAN, Z. ASLİ, OZGU-ERDİNC, A. SEVAL, BUYUK, GUL NİHAL, OZDEMİR, EDA UREYEN, TAYMAN, CUNEYT, DİNC, BEDİA, and TEKİN, OZLEM MORALOGLU

Abstract

Studies evaluating the safety and efficacy of currently available vaccines for SARS-CoV-2 do not include pregnant women and newborns. Safety data for vaccinating pregnant women with the COVID-19 vaccine is urgently needed since the vaccine is the only way to protect the vulnerable population. The 33 years-old pregnant women, a healthcare worker as an obstetrician and gynecologist, was vaccinated with inactivated SARS-CoV-2 vaccine with two doses within 28 days apart as the recommended protocol, on her 29th week and 33rd week of pregnancy. The rest of the pregnancy was uneventful and she gave birth on the 38th week to a healthy infant. The infant was a healthy boy upon first evaluation. Maternal blood was sampled immediately after birth, cord blood was obtained from a neonate for the immunoglobulin testing method. COVID-19 IgG and IgM antibodies for spike antigen was reported maternal as 2.04 (reactive) and the cord blood as 1.36 (reactive in a low titration). In this case we report an infant with SARS-CoV-2 IgG and IgM antibodies detectable in cord blood after maternal vaccination with inactivated vaccine. [ABSTRACT FROM AUTHOR]

Published
2023
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22. Health care utilization and outcomes in older adults after Traumatic Brain Injury: a CENTER-TBI study

Author

van der Vlegel, M, Mikolić, A, Hee, Q, Kaplan, Z, Helmrich, I, van Veen, E, Andelic, N, Steinbuechel, N, Plass, A, Zeldovich, M, Wilson, L, Maas, A, Haagsma, J, Polinder, S, Åkerlund, C, George, P, Lanyon, L, Muraleedharan, V, Nelson, D, Amrein, K, Ezer, E, Kovács, N, Melegh, B, Nyirádi, J, Tamás, V, Vámos, Z, Sorinola, A, Andreassen, L, Anke, A, Frisvold, S, Antoni, A, Schwendenwein, E, Audibert, G, Azouvi, P, Azzolini, M, Beretta, L, Calvi, M, Bartels, R, Boogert, H, Barzó, P, Beauvais, R, Perera, N, Beer, R, Helbok, R, Bellander, B, Belli, A, Benali, H, Degos, V, Galanaud, D, Perlbarg, V, Berardino, M, Cavallo, S, Blaabjerg, M, Rosenlund, C, Schou, R, Bragge, P, Brazinova, A, Majdan, M, Taylor, M, Zelinkova, V, Brinck, V, Jarrett, M, Brooker, J, Donoghue, E, Synnot, A, Brorsson, C, Koskinen, L, Sundström, N, Buki, A, Czeiter, E, Bullinger, M, Cabeleira, M, Czosnyka, M, Dixit, A, Ercole, A, Koraropoulos, E, Menon, D, Newcombe, V, Richter, S, Smielewski, P, Stamatakis, E, Williams, G, Winzeck, S, Zeiler, F, Caccioppola, A, Calappi, E, Carbonara, M, Ortolano, F, Zoerle, T, Stocchetti, N, Cameron, P, Gantner, D, Murray, L, Trapani, T, Vallance, S, Lozano, G, Pomposo, I, Castaño-León, A, Gomez, P, Lagares, A, Chevallard, G, Chieregato, A, Citerio, G, Vargiolu, A, Ceyisakar, I, Gravesteijn, B, Huijben, J, Lingsma, H, Nieboer, D, Mikolic, A, Sewalt, C, Steyerberg, E, Velt, K, Voormolen, D, Wiegers, E, Peul, W, van Dijck, J, van Essen, T, van Wijk, R, Clusmann, H, Coburn, M, Kowark, A, Rossaint, R, Coles, J, Cooper, J, Correia, M, Čovid, A, von Steinbüchel, N, Curry, N, Stanworth, S, Dahyot-Fizelier, C, Dark, P, Johnson, F, Dawes, H, Esser, P, van Heugten, C, De Keyser, V, Menovsky, T, Van der Steen, G, Corte, F, Grossi, F, Depreitere, B, Đilvesi, Đ, Golubovic, J, Karan, M, Vulekovic, P, Dreier, J, Vajkoczy, P, Wolf, S, Dulière, G, Maréchal, H, Fabricius, M, Kondziella, D, Feigin, V, Jones, K, Ao, B, Theadom, A, Foks, K, Haitsma, I, Volovici, V, Furmanov, A, Rosenthal, G, Gagliardo, P, Gao, G, Jiang, J, Ghuysen, A, Giga, L, Valeinis, E, Ziverte, A, Glocker, B, Rueckert, D, Gratz, J, Gruen, R, Gupta, D, Roe, C, Helseth, E, Roise, O, Horton, L, Hutchinson, P, Kolias, A, Jacobs, B, van der Naalt, J, Jankowski, S, Kompanje, E, Timmers, M, Laureys, S, Ledoux, D, Misset, B, Lecky, F, Olubukola, O, Lefering, R, Schäfer, N, Legrand, V, Lejeune, A, Vega, E, Mattern, J, Levi, L, Lightfoot, R, Maegele, M, Manara, A, Thomas, M, Manley, G, Martino, C, Sakowitz, O, Sanchez-Porras, R, Younsi, A, Mcmahon, C, Negru, A, Oresic, M, Palotie, A, Parizel, P, Payen, J, Persona, P, Piippo-Karjalainen, A, Pirinen, M, Ples, H, Posti, J, Puybasset, L, Radoi, A, Ragauskas, A, Raj, R, Rambadagalla, M, Rhodes, J, Richardson, S, Ripatti, S, Rocka, S, Rosand, J, Rosenfeld, J, Rossi, S, Rusnák, M, Sahuquillo, J, Sandor, J, Schmidt, S, Schoechl, H, Schoonman, G, Skandsen, T, Stevens, R, Stewart, W, Takala, R, Tamosuitis, T, Tenovuo, O, Tibboel, D, Tolias, C, Tudora, C, van der Jagt, M, Van Hecke, W, Van Praag, D, Vyvere, T, Verheyden, J, Vespa, P, Vik, A, Vilcinis, R, Wang, K, Yang, Z, Ylén, P, van der Vlegel, Marjolein, Mikolić, Ana, Hee, Quentin Lee, Kaplan, Z. L. Rana, Helmrich, Isabel R. A. Retel, van Veen, Ernest, Andelic, Nada, Steinbuechel, Nicole v., Plass, Anne Marie, Zeldovich, Marina, Wilson, Lindsay, Maas, Andrew I. R., Haagsma, Juanita A., Polinder, Suzanne, Åkerlund, Cecilia, George, Pradeep, Lanyon, Linda, Muraleedharan, Visakh, Nelson, David, Amrein, Krisztina, Ezer, Erzsébet, Kovács, Noémi, Melegh, Béla, Nyirádi, József, Tamás, Viktória, Vámos, Zoltán, Sorinola, Abayomi, Andreassen, Lasse, Anke, Audny, Frisvold, Shirin, Antoni, Anna, Schwendenwein, Elisabeth, Audibert, Gérard, Azouvi, Philippe, Azzolini, Maria Luisa, Beretta, Luigi, Calvi, Maria Rosa, Bartels, Ronald, Boogert, Hugo den, Barzó, Pál, Beauvais, Romuald, Perera, Natascha, Beer, Ronny, Helbok, Raimund, Bellander, Bo-Michael, Belli, Antonio, Benali, Habib, Degos, Vincent, Galanaud, Damien, Perlbarg, Vincent, Berardino, Maurizio, Cavallo, Simona, Blaabjerg, Morten, Rosenlund, Christina, Schou, Rico Frederik, Bragge, Peter, Brazinova, Alexandra, Majdan, Marek, Taylor, Mark Steven, Zelinkova, Veronika, Brinck, Vibeke, Jarrett, Mike, Brooker, Joanne, Donoghue, Emma, Synnot, Anneliese, Brorsson, Camilla, Koskinen, Lars-Owe, Sundström, Nina, Buki, Andras, Czeiter, Endre, Bullinger, Monika, Cabeleira, Manuel, Czosnyka, Marek, Dixit, Abhishek, Ercole, Ari, Koraropoulos, Evgenios, Menon, David, Newcombe, Virginia, Richter, Sophie, Smielewski, Peter, Stamatakis, Emmanuel, Williams, Guy, Winzeck, Stefan, Zeiler, Frederick A., Caccioppola, Alessio, Calappi, Emiliana, Carbonara, Marco, Ortolano, Fabrizio, Zoerle, Tommaso, Stocchetti, Nino, Cameron, Peter, Gantner, Dashiell, Murray, Lynnette, Trapani, Tony, Vallance, Shirley, Lozano, Guillermo Carbayo, Pomposo, Inigo, Castaño-León, Ana M., Gomez, Pedro A., Lagares, Alfonso, Chevallard, Giorgio, Chieregato, Arturo, Citerio, Giuseppe, Vargiolu, Alessia, Ceyisakar, Iris, Gravesteijn, Benjamin, Huijben, Jilske, Lingsma, Hester, Nieboer, Daan, Mikolic, Ana, Sewalt, Charlie, Steyerberg, Ewout W., Velt, Kimberley, Voormolen, Daphne, Wiegers, Eveline, Peul, Wilco, van Dijck, Jeroen T. J. M., van Essen, Thomas A., van Wijk, Roel P. J., Clusmann, Hans, Coburn, Mark, Kowark, Ana, Rossaint, Rolf, Coles, Jonathan, Cooper, Jamie D., Correia, Marta, Čovid, Amra, von Steinbüchel, Nicole, Curry, Nicola, Stanworth, Simon, Dahyot-Fizelier, Claire, Dark, Paul, Johnson, Faye, Dawes, Helen, Esser, Patrick, van Heugten, Caroline, De Keyser, Véronique, Menovsky, Tomas, Van der Steen, Gregory, Corte, Francesco Della, Grossi, Francesca, Depreitere, Bart, Đilvesi, Đula, Golubovic, Jagoš, Karan, Mladen, Vulekovic, Petar, Dreier, Jens, Vajkoczy, Peter, Wolf, Stefan, Dulière, Guy-Loup, Maréchal, Hugues, Fabricius, Martin, Kondziella, Daniel, Feigin, Valery L., Jones, Kelly, Ao, Braden Te, Theadom, Alice, Foks, Kelly, Haitsma, Iain, Volovici, Victor, Furmanov, Alex, Rosenthal, Guy, Gagliardo, Pablo, Gao, Guoyi, Jiang, Ji-yao, Ghuysen, Alexandre, Giga, Lelde, Valeinis, Egils, Ziverte, Agate, Glocker, Ben, Rueckert, Daniel, Gratz, Johannes, Gruen, Russell L., Gupta, Deepak, Roe, Cecilie, Helseth, Eirik, Roise, Olav, Horton, Lindsay, Hutchinson, Peter J., Kolias, Angelos G., Jacobs, Bram, van der Naalt, Joukje, Jankowski, Stefan, Kompanje, Erwin, Timmers, Marjolein, Laureys, Steven, Ledoux, Didier, Misset, Benoit, Lecky, Fiona, Olubukola, Otesile, Lefering, Rolf, Schäfer, Nadine, Legrand, Valerie, Lejeune, Aurelie, Vega, Emmanuel, Mattern, Julia, Levi, Leon, Lightfoot, Roger, Maegele, Marc, Manara, Alex, Thomas, Matt, Manley, Geoffrey, Martino, Costanza, Sakowitz, Oliver, Sanchez-Porras, Renan, Younsi, Alexander, McMahon, Catherine, Negru, Ancuta, Oresic, Matej, Palotie, Aarno, Parizel, Paul M., Payen, Jean-François, Persona, Paolo, Piippo-Karjalainen, Anna, Pirinen, Matti, Ples, Horia, Posti, Jussi P., Puybasset, Louis, Radoi, Andreea, Ragauskas, Arminas, Raj, Rahul, Rambadagalla, Malinka, Rhodes, Jonathan, Richardson, Sylvia, Ripatti, Samuli, Rocka, Saulius, Rosand, Jonathan, Rosenfeld, Jeffrey V., Rossi, Sandra, Rusnák, Martin, Sahuquillo, Juan, Sandor, Janos, Schmidt, Silke, Schoechl, Herbert, Schoonman, Guus, Skandsen, Toril, Stevens, Robert, Stewart, William, Takala, Riikka, Tamosuitis, Tomas, Tenovuo, Olli, Tibboel, Dick, Tolias, Christos, Tudora, Cristina Maria, van der Jagt, Mathieu, Van Hecke, Wim, Van Praag, Dominique, Vyvere, Thijs Vande, Verheyden, Jan, Vespa, Paul M., Vik, Anne, Vilcinis, Rimantas, Wang, Kevin K. W., Yang, Zhihui, Ylén, Peter, van der Vlegel, M, Mikolić, A, Hee, Q, Kaplan, Z, Helmrich, I, van Veen, E, Andelic, N, Steinbuechel, N, Plass, A, Zeldovich, M, Wilson, L, Maas, A, Haagsma, J, Polinder, S, Åkerlund, C, George, P, Lanyon, L, Muraleedharan, V, Nelson, D, Amrein, K, Ezer, E, Kovács, N, Melegh, B, Nyirádi, J, Tamás, V, Vámos, Z, Sorinola, A, Andreassen, L, Anke, A, Frisvold, S, Antoni, A, Schwendenwein, E, Audibert, G, Azouvi, P, Azzolini, M, Beretta, L, Calvi, M, Bartels, R, Boogert, H, Barzó, P, Beauvais, R, Perera, N, Beer, R, Helbok, R, Bellander, B, Belli, A, Benali, H, Degos, V, Galanaud, D, Perlbarg, V, Berardino, M, Cavallo, S, Blaabjerg, M, Rosenlund, C, Schou, R, Bragge, P, Brazinova, A, Majdan, M, Taylor, M, Zelinkova, V, Brinck, V, Jarrett, M, Brooker, J, Donoghue, E, Synnot, A, Brorsson, C, Koskinen, L, Sundström, N, Buki, A, Czeiter, E, Bullinger, M, Cabeleira, M, Czosnyka, M, Dixit, A, Ercole, A, Koraropoulos, E, Menon, D, Newcombe, V, Richter, S, Smielewski, P, Stamatakis, E, Williams, G, Winzeck, S, Zeiler, F, Caccioppola, A, Calappi, E, Carbonara, M, Ortolano, F, Zoerle, T, Stocchetti, N, Cameron, P, Gantner, D, Murray, L, Trapani, T, Vallance, S, Lozano, G, Pomposo, I, Castaño-León, A, Gomez, P, Lagares, A, Chevallard, G, Chieregato, A, Citerio, G, Vargiolu, A, Ceyisakar, I, Gravesteijn, B, Huijben, J, Lingsma, H, Nieboer, D, Mikolic, A, Sewalt, C, Steyerberg, E, Velt, K, Voormolen, D, Wiegers, E, Peul, W, van Dijck, J, van Essen, T, van Wijk, R, Clusmann, H, Coburn, M, Kowark, A, Rossaint, R, Coles, J, Cooper, J, Correia, M, Čovid, A, von Steinbüchel, N, Curry, N, Stanworth, S, Dahyot-Fizelier, C, Dark, P, Johnson, F, Dawes, H, Esser, P, van Heugten, C, De Keyser, V, Menovsky, T, Van der Steen, G, Corte, F, Grossi, F, Depreitere, B, Đilvesi, Đ, Golubovic, J, Karan, M, Vulekovic, P, Dreier, J, Vajkoczy, P, Wolf, S, Dulière, G, Maréchal, H, Fabricius, M, Kondziella, D, Feigin, V, Jones, K, Ao, B, Theadom, A, Foks, K, Haitsma, I, Volovici, V, Furmanov, A, Rosenthal, G, Gagliardo, P, Gao, G, Jiang, J, Ghuysen, A, Giga, L, Valeinis, E, Ziverte, A, Glocker, B, Rueckert, D, Gratz, J, Gruen, R, Gupta, D, Roe, C, Helseth, E, Roise, O, Horton, L, Hutchinson, P, Kolias, A, Jacobs, B, van der Naalt, J, Jankowski, S, Kompanje, E, Timmers, M, Laureys, S, Ledoux, D, Misset, B, Lecky, F, Olubukola, O, Lefering, R, Schäfer, N, Legrand, V, Lejeune, A, Vega, E, Mattern, J, Levi, L, Lightfoot, R, Maegele, M, Manara, A, Thomas, M, Manley, G, Martino, C, Sakowitz, O, Sanchez-Porras, R, Younsi, A, Mcmahon, C, Negru, A, Oresic, M, Palotie, A, Parizel, P, Payen, J, Persona, P, Piippo-Karjalainen, A, Pirinen, M, Ples, H, Posti, J, Puybasset, L, Radoi, A, Ragauskas, A, Raj, R, Rambadagalla, M, Rhodes, J, Richardson, S, Ripatti, S, Rocka, S, Rosand, J, Rosenfeld, J, Rossi, S, Rusnák, M, Sahuquillo, J, Sandor, J, Schmidt, S, Schoechl, H, Schoonman, G, Skandsen, T, Stevens, R, Stewart, W, Takala, R, Tamosuitis, T, Tenovuo, O, Tibboel, D, Tolias, C, Tudora, C, van der Jagt, M, Van Hecke, W, Van Praag, D, Vyvere, T, Verheyden, J, Vespa, P, Vik, A, Vilcinis, R, Wang, K, Yang, Z, Ylén, P, van der Vlegel, Marjolein, Mikolić, Ana, Hee, Quentin Lee, Kaplan, Z. L. Rana, Helmrich, Isabel R. A. Retel, van Veen, Ernest, Andelic, Nada, Steinbuechel, Nicole v., Plass, Anne Marie, Zeldovich, Marina, Wilson, Lindsay, Maas, Andrew I. R., Haagsma, Juanita A., Polinder, Suzanne, Åkerlund, Cecilia, George, Pradeep, Lanyon, Linda, Muraleedharan, Visakh, Nelson, David, Amrein, Krisztina, Ezer, Erzsébet, Kovács, Noémi, Melegh, Béla, Nyirádi, József, Tamás, Viktória, Vámos, Zoltán, Sorinola, Abayomi, Andreassen, Lasse, Anke, Audny, Frisvold, Shirin, Antoni, Anna, Schwendenwein, Elisabeth, Audibert, Gérard, Azouvi, Philippe, Azzolini, Maria Luisa, Beretta, Luigi, Calvi, Maria Rosa, Bartels, Ronald, Boogert, Hugo den, Barzó, Pál, Beauvais, Romuald, Perera, Natascha, Beer, Ronny, Helbok, Raimund, Bellander, Bo-Michael, Belli, Antonio, Benali, Habib, Degos, Vincent, Galanaud, Damien, Perlbarg, Vincent, Berardino, Maurizio, Cavallo, Simona, Blaabjerg, Morten, Rosenlund, Christina, Schou, Rico Frederik, Bragge, Peter, Brazinova, Alexandra, Majdan, Marek, Taylor, Mark Steven, Zelinkova, Veronika, Brinck, Vibeke, Jarrett, Mike, Brooker, Joanne, Donoghue, Emma, Synnot, Anneliese, Brorsson, Camilla, Koskinen, Lars-Owe, Sundström, Nina, Buki, Andras, Czeiter, Endre, Bullinger, Monika, Cabeleira, Manuel, Czosnyka, Marek, Dixit, Abhishek, Ercole, Ari, Koraropoulos, Evgenios, Menon, David, Newcombe, Virginia, Richter, Sophie, Smielewski, Peter, Stamatakis, Emmanuel, Williams, Guy, Winzeck, Stefan, Zeiler, Frederick A., Caccioppola, Alessio, Calappi, Emiliana, Carbonara, Marco, Ortolano, Fabrizio, Zoerle, Tommaso, Stocchetti, Nino, Cameron, Peter, Gantner, Dashiell, Murray, Lynnette, Trapani, Tony, Vallance, Shirley, Lozano, Guillermo Carbayo, Pomposo, Inigo, Castaño-León, Ana M., Gomez, Pedro A., Lagares, Alfonso, Chevallard, Giorgio, Chieregato, Arturo, Citerio, Giuseppe, Vargiolu, Alessia, Ceyisakar, Iris, Gravesteijn, Benjamin, Huijben, Jilske, Lingsma, Hester, Nieboer, Daan, Mikolic, Ana, Sewalt, Charlie, Steyerberg, Ewout W., Velt, Kimberley, Voormolen, Daphne, Wiegers, Eveline, Peul, Wilco, van Dijck, Jeroen T. J. M., van Essen, Thomas A., van Wijk, Roel P. J., Clusmann, Hans, Coburn, Mark, Kowark, Ana, Rossaint, Rolf, Coles, Jonathan, Cooper, Jamie D., Correia, Marta, Čovid, Amra, von Steinbüchel, Nicole, Curry, Nicola, Stanworth, Simon, Dahyot-Fizelier, Claire, Dark, Paul, Johnson, Faye, Dawes, Helen, Esser, Patrick, van Heugten, Caroline, De Keyser, Véronique, Menovsky, Tomas, Van der Steen, Gregory, Corte, Francesco Della, Grossi, Francesca, Depreitere, Bart, Đilvesi, Đula, Golubovic, Jagoš, Karan, Mladen, Vulekovic, Petar, Dreier, Jens, Vajkoczy, Peter, Wolf, Stefan, Dulière, Guy-Loup, Maréchal, Hugues, Fabricius, Martin, Kondziella, Daniel, Feigin, Valery L., Jones, Kelly, Ao, Braden Te, Theadom, Alice, Foks, Kelly, Haitsma, Iain, Volovici, Victor, Furmanov, Alex, Rosenthal, Guy, Gagliardo, Pablo, Gao, Guoyi, Jiang, Ji-yao, Ghuysen, Alexandre, Giga, Lelde, Valeinis, Egils, Ziverte, Agate, Glocker, Ben, Rueckert, Daniel, Gratz, Johannes, Gruen, Russell L., Gupta, Deepak, Roe, Cecilie, Helseth, Eirik, Roise, Olav, Horton, Lindsay, Hutchinson, Peter J., Kolias, Angelos G., Jacobs, Bram, van der Naalt, Joukje, Jankowski, Stefan, Kompanje, Erwin, Timmers, Marjolein, Laureys, Steven, Ledoux, Didier, Misset, Benoit, Lecky, Fiona, Olubukola, Otesile, Lefering, Rolf, Schäfer, Nadine, Legrand, Valerie, Lejeune, Aurelie, Vega, Emmanuel, Mattern, Julia, Levi, Leon, Lightfoot, Roger, Maegele, Marc, Manara, Alex, Thomas, Matt, Manley, Geoffrey, Martino, Costanza, Sakowitz, Oliver, Sanchez-Porras, Renan, Younsi, Alexander, McMahon, Catherine, Negru, Ancuta, Oresic, Matej, Palotie, Aarno, Parizel, Paul M., Payen, Jean-François, Persona, Paolo, Piippo-Karjalainen, Anna, Pirinen, Matti, Ples, Horia, Posti, Jussi P., Puybasset, Louis, Radoi, Andreea, Ragauskas, Arminas, Raj, Rahul, Rambadagalla, Malinka, Rhodes, Jonathan, Richardson, Sylvia, Ripatti, Samuli, Rocka, Saulius, Rosand, Jonathan, Rosenfeld, Jeffrey V., Rossi, Sandra, Rusnák, Martin, Sahuquillo, Juan, Sandor, Janos, Schmidt, Silke, Schoechl, Herbert, Schoonman, Guus, Skandsen, Toril, Stevens, Robert, Stewart, William, Takala, Riikka, Tamosuitis, Tomas, Tenovuo, Olli, Tibboel, Dick, Tolias, Christos, Tudora, Cristina Maria, van der Jagt, Mathieu, Van Hecke, Wim, Van Praag, Dominique, Vyvere, Thijs Vande, Verheyden, Jan, Vespa, Paul M., Vik, Anne, Vilcinis, Rimantas, Wang, Kevin K. W., Yang, Zhihui, and Ylén, Peter

Abstract

Introduction: The incidence of Traumatic Brain Injury (TBI) is increasingly common in older adults aged ≥65 years, forming a growing public health problem. However, older adults are underrepresented in TBI research. Therefore, we aimed to provide an overview of health-care utilization, and of six-month outcomes after TBI and their determinants in older adults who sustained a TBI. Methods: We used data from the prospective multi-center Collaborative European NeuroTrauma Effectiveness Research in Traumatic Brain Injury (CENTER-TBI) study. In-hospital and post-hospital health care utilization and outcomes were described for patients aged ≥65 years. Ordinal and linear regression analyses were performed to identify determinants of the Glasgow Outcome Scale Extended (GOSE), health-related quality of life (HRQoL), and mental health symptoms six-months post-injury. Results: Of 1254 older patients, 45% were admitted to an ICU with a mean length of stay of 9 days. Nearly 30% of the patients received inpatient rehabilitation. In total, 554/1254 older patients completed the six-month follow-up questionnaires. The mortality rate was 9% after mild and 60% after moderate/severe TBI, and full recovery based on GOSE was reported for 44% of patients after mild and 6% after moderate/severe TBI. Higher age and increased injury severity were primarily associated with functional impairment, while pre-injury systemic disease, psychiatric conditions and lower educational level were associated with functional impairment, lower generic and disease-specific HRQoL and mental health symptoms. Conclusion: The rate of impairment and disability following TBI in older adults is substantial, and poorer outcomes across domains are associated with worse preinjury health. Nonetheless, a considerable number of patients fully or partially returns to their preinjury functioning. There should not be pessimism about outcomes in older adults who survive.

Published
2022

23. Intramural Healthcare Consumption and Costs After Traumatic Brain Injury:A Collaborative European NeuroTrauma Effectiveness Research in Traumatic Brain Injury (CENTER-TBI) Study

Author

Kaplan, Z. L.Rana, van der Vlegel, Marjolein, van Dijck, Jeroen T.J.M., Pisică, Dana, van Leeuwen, Nikki, Lingsma, Hester F., Steyerberg, Ewout W., Haagsma, Juanita A., Majdan, Marek, Polinder, Suzanne, Kaplan, Z. L.Rana, van der Vlegel, Marjolein, van Dijck, Jeroen T.J.M., Pisică, Dana, van Leeuwen, Nikki, Lingsma, Hester F., Steyerberg, Ewout W., Haagsma, Juanita A., Majdan, Marek, and Polinder, Suzanne

Abstract

Traumatic brain injury (TBI) is a global public health problem and a leading cause of mortality, morbidity, and disability. The increasing incidence combined with the heterogeneity and complexity of TBI will inevitably place a substantial burden on health systems. These findings emphasize the importance of obtaining accurate and timely insights into healthcare consumption and costs on a multi-national scale. This study aimed to describe intramural healthcare consumption and costs across the full spectrum of TBI in Europe. The Collaborative European NeuroTrauma Effectiveness Research in Traumatic Brain Injury (CENTER-TBI) core study is a prospective observational study conducted in 18 countries across Europe and in Israel. The baseline Glasgow Coma Scale (GCS) was used to differentiate patients by brain injury severity in mild (GCS 13–15), moderate (GCS 9–12), or severe (GCS £8) TBI. We analyzed seven main cost categories: pre-hospital care, hospital admission, surgical interventions, imaging, laboratory, blood products, and rehabilitation. Costs were estimated based on Dutch reference prices and converted to country-specific unit prices using gross domestic product (GDP)-purchasing power parity (PPP) adjustment. Mixed linear regression was used to identify between-country differences in length of stay (LOS), as a parameter of healthcare consumption. Mixed generalized linear models with gamma distribution and log link function quantified associations of patient characteristics with higher total costs. We included 4349 patients, of whom 2854 (66%) had mild, 371 (9%) had moderate, and 962 (22%) had severe TBI. Hospitalization accounted for the largest part of the intramural consumption and costs (60%). In the total study population, the mean LOS was 5.1 days at the intensive care unit (ICU) and 6.3 days at the ward. For mild, moderate, and severe TBI, mean LOS was, respectively, 1.8, 8.9, and 13.5 days at the ICU and 4.5, 10.1, and 10.3 days at the ward. Other large

Published
2023

26. S291: PHASE I/II STUDY OF RILZABRUTINIB, AN ORAL BRUTON TYROSINE KINASE INHIBITOR, IN PATIENTS WITH IMMUNE THROMBOCYTOPENIA: LONG-TERM FOLLOW-UP

Author

Kuter, D. J., primary, Efraim, M., additional, Kaplan, Z., additional, Mayer, J., additional, Choi, P., additional, Jansen, A. G., additional, McDonald, V., additional, Baker, R., additional, Bird, R., additional, Garg, M., additional, Gumulec, J., additional, Kostal, M., additional, Gernsheimer, T., additional, Ghanima, W., additional, Yao, M., additional, Daak, A., additional, and Cooper, N., additional

Published
2022
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27. Newborn Hearing Screening Results of Infants Born To Mothers Who Had COVID-19 Disease During Pregnancy: A Retrospective Cohort Study

Author

Sahin, Dilek, Demir, Barış, Ali-Algan, Cavide, Sert-Dinç, U. Yasemin, Büyük, Gül Nihal, Özgü-Erdinç, A. Seval, Öskovi-Kaplan, Z. Aslı, Sahin, Dilek, Demir, Barış, Ali-Algan, Cavide, Sert-Dinç, U. Yasemin, Büyük, Gül Nihal, Özgü-Erdinç, A. Seval, and Öskovi-Kaplan, Z. Aslı

Abstract

Objective: Viral infections are known to be a risk factor for neonatal hearing loss. COVID-19 infection has been reported to affect hearing test results in one small sample sized study. We aimed to investigate the incidence the risk of neonatal hearing loss in infants of mothers who had COVID-19 infection during pregnancy, regarding their trimesters, by evaluating the neonatal hearing screening results. Design: In this retrospective case-control study, neonatal hearing test results of 458 women with a history of COVID-19 infection in pregnancy were compared with 339 women who gave birth before the pandemic. Data of pregnant women who attended the COVID-19 outpatient clinic of the emergency service of a tertiary pandemic hospital and who had confirmed infection with a reverse transcriptase-polymerase chain reaction (RT-PCR) test were determined from the hospital's records and their neonatal hearing screening results were analyzed from the national database. Neonates born before 34 weeks, and with reported risk factors in the database such as congenital anomaly or known TORCH infection during pregnancy were excluded. The screening tests, Automated Auditory Brainstem Response or Transient Evoked Otoacoustic Emission (TEOAE), were used for screening, and patients who failed the first screening were reevaluated at least 2 weeks apart with a second screening. Results: The incidence of failed second screening was 1.3% in the COVID-19 group and 2.9% in controls, and no significant difference was observed between the two groups according to the final screening results on the second test. Among the 458 mothers, 8 were infected in first trimester, 126 in second trimester, 127 in third trimester but did not deliver within 15 days after infection and 197 were positive at birth. Six neonates in the infected group failed the second screening (3 [2.4%] in the second trimester, 1 [0.8%] third trimester, and 2 [1.0%] positive at birth). Conclusions: COVID-19 infection during pregnanc

Published
2022

28. Rilzabrutinib, an Oral BTK Inhibitor, in Immune Thrombocytopenia.

Author

Kuter D.J., Efraim M., Mayer J., Trneny M., McDonald V., Bird R., Regenbogen T., Garg M., Kaplan Z., Tzvetkov N., Choi P.Y., Jansen A.J.G., Kostal M., Baker R., Gumulec J., Lee E.-J., Cunningham I., Goncalves I., Warner M., Boccia R., Gernsheimer T., Ghanima W., Bandman O., Burns R., Neale A., Thomas D., Arora P., Zheng B., Cooper N., Kuter D.J., Efraim M., Mayer J., Trneny M., McDonald V., Bird R., Regenbogen T., Garg M., Kaplan Z., Tzvetkov N., Choi P.Y., Jansen A.J.G., Kostal M., Baker R., Gumulec J., Lee E.-J., Cunningham I., Goncalves I., Warner M., Boccia R., Gernsheimer T., Ghanima W., Bandman O., Burns R., Neale A., Thomas D., Arora P., Zheng B., and Cooper N.

Abstract

BACKGROUND Rilzabrutinib, an oral, reversible covalent inhibitor of Bruton's tyrosine kinase, may increase platelet counts in patients with immune thrombocytopenia by means of dual mechanisms of action: decreased macrophage (Fcgamma receptor)-mediated platelet destruction and reduced production of pathogenic autoantibodies. METHODS In an international, adaptive, open-label, dose-finding, phase 1-2 clinical trial, we evaluated rilzabrutinib therapy in previously treated patients with immune thrombocytopenia. We used intrapatient dose escalation of oral rilzabrutinib over a period of 24 weeks; the lowest starting dose was 200 mg once daily, with higher starting doses of 400 mg once daily, 300 mg twice daily, and 400 mg twice daily. The primary end points were safety and platelet response (defined as at least two consecutive platelet counts of >=50x103 per cubic millimeter and an increase from baseline of >=20x103 per cubic millimeter without the use of rescue medication). RESULTS Sixty patients were enrolled. At baseline, the median platelet count was 15x103 per cubic millimeter, the median duration of disease was 6.3 years, and patients had received a median of four different immune thrombocytopenia therapies previously. All the treatment-related adverse events were of grade 1 or 2 and transient. There were no treatment-related bleeding or thrombotic events of grade 2 or higher. At a median of 167.5 days (range, 4 to 293) of treatment, 24 of 60 patients (40%) overall and 18 of the 45 patients (40%) who had started rilzabrutinib treatment at the highest dose met the primary end point of platelet response. The median time to the first platelet count of at least 50x103 per cubic millimeter was 11.5 days. Among patients with a primary platelet response, the mean percentage of weeks with a platelet count of at least 50x103 per cubic millimeter was 65%. CONCLUSIONS Rilzabrutinib was active and associated with only low-level toxic effects at all dose levels. The dose of 400

Published
2022

29. Updated Phase I/II Safety and Efficacy Results for Oral Bruton Tyrosine Kinase Inhibitor Rilzabrutinib in Patients with Relapsed/Refractory Immune Thrombocytopenia.

Author

Kuter D.J., Tzvetkov N., Efraim M., Kaplan Z., Mayer J., Choi P., Jansen A.J.G., McDonald V., Baker R., Bird R.J., Garg M., Gumulec J., Kostal M., Gernsheimer T., Ghanima W., Bandman O., Arora P., Burns R., Yao M., Daak A., Sourdille T., Iqbal F., Thomas D., Neale A., Cooper N., Kuter D.J., Tzvetkov N., Efraim M., Kaplan Z., Mayer J., Choi P., Jansen A.J.G., McDonald V., Baker R., Bird R.J., Garg M., Gumulec J., Kostal M., Gernsheimer T., Ghanima W., Bandman O., Arora P., Burns R., Yao M., Daak A., Sourdille T., Iqbal F., Thomas D., Neale A., and Cooper N.

Abstract

Introduction: Key characteristics of immune thrombocytopenia (ITP) include immune-mediated platelet destruction/impaired production, with resultant thrombocytopenia and increased bleeding risk. Durable response to current therapies remains an unmet need, particularly in the relapsed/refractory setting. Rilzabrutinib is the first oral, reversible, covalent inhibitor of Bruton tyrosine kinase designed to target immune-mediated pathways in ITP without inhibiting normal platelet aggregation. Initial phase I/II results in ITP demonstrated rapid and durable efficacy with rilzabrutinib that was well-tolerated at all dose levels, including the optimal 400 mg bid dose. Interim results on rilzabrutinib effects in patients with relapsed/refractory ITP were previously reported. Here we present long-term data from a larger group of patients who initiated rilzabrutinib at 400 mg bid and are continuing in the long-term extension (LTE) period. Method(s): This ongoing, global phase I/II study (NCT03395210) enrolled adult patients from 8 countries with relapsed or refractory ITP who previously responded to >=1 prior ITP therapy. Eligible patients with 2 baseline platelet counts of <30x10 9/L no less than 7 days apart in the 15 days before baseline received oral rilzabrutinib at starting doses of 200 or 400 mg QD, 300 or 400 mg bid for 24 weeks; intrapatient dose escalation was permitted to improve efficacy. Stable doses of concomitant corticosteroids and thrombopoietin receptor agonists were allowed for patients with inadequate platelet response. The primary endpoints were safety and achievement of >=2 consecutive platelet counts >=50x10 9/L and increased >=20x10 9/L from baseline without rescue medication. Responding patients could continue in the LTE period with rilzabrutinib at the optimal 400 mg bid dose. Result(s): As of June 1, 2021 in 60 patients, 45 patients initiated rilzabrutinib 400 mg bid and to date, 16 patients with durable, stable response proceeded to LTE at 400 mg bi

Published
2022

30. Phase i/ii study of rilzabrutinib, an oral bruton tyrosine kinase inhibitor, in patients with immune thrombocytopenia: long-term follow-up.

Author

Kuter D.J., Efraim M., Kaplan Z., Mayer J., Choi P., Jansen A.J.G., McDonald V., Baker R., Bird R., Garg M., Gumulec J., Kostal M., Gernsheimer T., Ghanima W., Yao M., Daak A., Cooper N., Kuter D.J., Efraim M., Kaplan Z., Mayer J., Choi P., Jansen A.J.G., McDonald V., Baker R., Bird R., Garg M., Gumulec J., Kostal M., Gernsheimer T., Ghanima W., Yao M., Daak A., and Cooper N.

Abstract

Background: Immune thrombocytopenia (ITP) is an autoimmune disease associated with autoantibody-mediated platelet destruction and impaired platelet production, resulting in thrombocytopenia and high bleeding risk. In a global phase I/II trial (NCT03395210) of heaily pretreated patients with long-standing disease, the Bruton tyrosine kinase inhibitor rilzabrutinib showed a rapid and durable platelet count increase and was well tolerated. We present results for patients initiating rilzabrutinib 400 mg BID who are continuing in the long-term extension (LTE). Aim(s): Assess if the efficacy and safety of rilzabrutinib 400 mg BID continue to be maintained in LTE patients on rilzabrutinib +/- concomitant medication. Method(s): Patients with 2 baseline platelet counts <30x109/L were required to hae responded to >=1 prior ITP therapy but at baseline were unable to maintain an adequate response to prior/concomitant therapies. The main treatment period was 24 weeks; patients who achieed platelet counts >=50x109/L at >=50% of the isits during the last 8 weeks of the main period were permitted to continue 400 mg BID in the LTE. Primary endpoints were safety and efficacy (>=2 consecutie platelet counts >=50x109/L and increased >=20x109/L from baseline without requiring rescue medication). Stable doses of concomitant ITP medication (thrombopoietin-receptor agonists [TPO-RA] and corticosteroids [CS]) were allowed for patients with inadequate platelet response. Patients who receied rescue medication discontinued from the study. All patients proided informed consent. Result(s): At baseline, the 45 patients initiating 400 mg BID in the main period had a median age of 49 years, median duration of ITP of 6.1 years, median platelet count of 15x109/L, and a median of 4 unique prior therapies (24% prior splenectomy). A total of 15 patients (33%) receied rilzabrutinib monotherapy, and 30 had concomitant therapy (TPO-RA n=13 [29%], CS n=12 [27%], TPO-RA + CS n=5 [11%]). Primary platelet resp

Published
2022

31. Newborn Hearing Screening Results of Infants Born To Mothers Who Had COVID-19 Disease During Pregnancy: A Retrospective Cohort Study

Author

Öskovi-Kaplan, Z. Aslı, Özgü-Erdinç, A. Seval, Büyük, Gül Nihal, Sert-Dinç, U. Yasemin, Ali-Algan, Cavide, Demir, Barış, Sahin, Dilek, Öskovi-Kaplan, Z. Aslı, Özgü-Erdinç, A. Seval, Büyük, Gül Nihal, Sert-Dinç, U. Yasemin, Ali-Algan, Cavide, Demir, Barış, and Sahin, Dilek

Abstract

Objective: Viral infections are known to be a risk factor for neonatal hearing loss. COVID-19 infection has been reported to affect hearing test results in one small sample sized study. We aimed to investigate the incidence the risk of neonatal hearing loss in infants of mothers who had COVID-19 infection during pregnancy, regarding their trimesters, by evaluating the neonatal hearing screening results. Design: In this retrospective case-control study, neonatal hearing test results of 458 women with a history of COVID-19 infection in pregnancy were compared with 339 women who gave birth before the pandemic. Data of pregnant women who attended the COVID-19 outpatient clinic of the emergency service of a tertiary pandemic hospital and who had confirmed infection with a reverse transcriptase-polymerase chain reaction (RT-PCR) test were determined from the hospital's records and their neonatal hearing screening results were analyzed from the national database. Neonates born before 34 weeks, and with reported risk factors in the database such as congenital anomaly or known TORCH infection during pregnancy were excluded. The screening tests, Automated Auditory Brainstem Response or Transient Evoked Otoacoustic Emission (TEOAE), were used for screening, and patients who failed the first screening were reevaluated at least 2 weeks apart with a second screening. Results: The incidence of failed second screening was 1.3% in the COVID-19 group and 2.9% in controls, and no significant difference was observed between the two groups according to the final screening results on the second test. Among the 458 mothers, 8 were infected in first trimester, 126 in second trimester, 127 in third trimester but did not deliver within 15 days after infection and 197 were positive at birth. Six neonates in the infected group failed the second screening (3 [2.4%] in the second trimester, 1 [0.8%] third trimester, and 2 [1.0%] positive at birth). Conclusions: COVID-19 infection during pregnanc

Published
2022

32. Health care utilization and outcomes in older adults after Traumatic Brain Injury:A CENTER-TBI study

Author

van der Vlegel, Marjolein, Mikolić, Ana, Lee Hee, Quentin, Kaplan, Z. L.Rana, Retel Helmrich, Isabel R.A., van Veen, Ernest, Andelic, Nada, Steinbuechel, Nicole v., Plass, Anne Marie, Zeldovich, Marina, Wilson, Lindsay, Maas, Andrew I.R., Haagsma, Juanita A., Polinder, Suzanne, van der Vlegel, Marjolein, Mikolić, Ana, Lee Hee, Quentin, Kaplan, Z. L.Rana, Retel Helmrich, Isabel R.A., van Veen, Ernest, Andelic, Nada, Steinbuechel, Nicole v., Plass, Anne Marie, Zeldovich, Marina, Wilson, Lindsay, Maas, Andrew I.R., Haagsma, Juanita A., and Polinder, Suzanne

Abstract

Introduction: The incidence of Traumatic Brain Injury (TBI) is increasingly common in older adults aged ≥65 years, forming a growing public health problem. However, older adults are underrepresented in TBI research. Therefore, we aimed to provide an overview of health-care utilization, and of six-month outcomes after TBI and their determinants in older adults who sustained a TBI. Methods: We used data from the prospective multi-center Collaborative European NeuroTrauma Effectiveness Research in Traumatic Brain Injury (CENTER-TBI) study. In-hospital and post-hospital health care utilization and outcomes were described for patients aged ≥65 years. Ordinal and linear regression analyses were performed to identify determinants of the Glasgow Outcome Scale Extended (GOSE), health-related quality of life (HRQoL), and mental health symptoms six-months post-injury. Results: Of 1254 older patients, 45% were admitted to an ICU with a mean length of stay of 9 days. Nearly 30% of the patients received inpatient rehabilitation. In total, 554/1254 older patients completed the six-month follow-up questionnaires. The mortality rate was 9% after mild and 60% after moderate/severe TBI, and full recovery based on GOSE was reported for 44% of patients after mild and 6% after moderate/severe TBI. Higher age and increased injury severity were primarily associated with functional impairment, while pre-injury systemic disease, psychiatric conditions and lower educational level were associated with functional impairment, lower generic and disease-specific HRQoL and mental health symptoms. Conclusion: The rate of impairment and disability following TBI in older adults is substantial, and poorer outcomes across domains are associated with worse preinjury health. Nonetheless, a considerable number of patients fully or partially returns to their preinjury functioning. There should not be pessimism about outcomes in older adults who survive.

Published
2022

33. Prediction Models for Future High-Need High-Cost Healthcare Use:a Systematic Review

Author

de Ruijter, Ursula W., Kaplan, Z. L.Rana, Bramer, Wichor M., Eijkenaar, Frank, Nieboer, Daan, van der Heide, Agnes, Lingsma, Hester F., Bax, Willem A., de Ruijter, Ursula W., Kaplan, Z. L.Rana, Bramer, Wichor M., Eijkenaar, Frank, Nieboer, Daan, van der Heide, Agnes, Lingsma, Hester F., and Bax, Willem A.

Abstract

Background: In an effort to improve both quality of care and cost-effectiveness, various care-management programmes have been developed for high-need high-cost (HNHC) patients. Early identification of patients at risk of becoming HNHC (i.e. case finding) is crucial to a programme’s success. We aim to systematically identify prediction models predicting future HNHC healthcare use in adults, to describe their predictive performance and to assess their applicability. Methods: Ovid MEDLINE® All, EMBASE, CINAHL, Web of Science and Google Scholar were systematically searched from inception through January 31, 2021. Risk of bias and methodological quality assessment was performed through the Prediction model Risk Of Bias Assessment Tool (PROBAST). Results: Of 5890 studies, 60 studies met inclusion criteria. Within these studies, 313 unique models were presented using a median development cohort size of 20,248 patients (IQR 5601–174,242). Predictors were derived from a combination of data sources, most often claims data (n = 37; 62%) and patient survey data (n = 29; 48%). Most studies (n = 36; 60%) estimated patients’ risk to become part of some top percentage of the cost distribution (top-1–20%) within a mean time horizon of 16 months (range 12–60). Five studies (8%) predicted HNHC persistence over multiple years. Model validation was performed in 45 studies (76%). Model performance in terms of both calibration and discrimination was reported in 14 studies (23%). Overall risk of bias was rated as ‘high’ in 40 studies (67%), mostly due to a ‘high’ risk of bias in the subdomain ‘Analysis’ (n = 37; 62%). Discussion: This is the first systematic review (PROSPERO CRD42020164734) of non-proprietary prognostic models predicting HNHC healthcare use. Meta-analysis was not possible due to heterogeneity. Most identified models estimated a patient’s risk to incur high healthcare expenditure during the subsequent year. However, case-finding strategies for HNHC care-management progra

Published
2022

35. Do fetuin-A/apha2-Heremans Schmid-glycoprotein levels have an association with recurrent pregnancy loss?

Author

Seval Ozgu-Erdinc, A., Asli Oskovi-Kaplan, Z., Erkenekli, Kudret, Yilmaz, Nafiye, Engin-Ustun, Yaprak, Yücel, Aykan, and Uygur, Dilek

Subjects
*RECURRENT miscarriage, *PREGNANCY complications, *PREGNANCY outcomes, *CERVICAL cerclage, *MISCARRIAGE
Abstract

Objective Fetuin-A is a hepatokine which is previously found related to fertility and pregnancy outcomes. We aimed to investigate if recurrent pregnancy loss (RPL) is associated with increased fetuin-A levels. Materials and methods Serum fetuin-A concentrations were measured and compared in 30 non-pregnant women with a history of unexplained recurrent miscarriage, 29 women who had a history of unexplained recurrent miscarriage and were admitted to our clinic due to miscarriage during the study period and 30 fertile women who have no history of miscarriage or any other pregnancy complications with at least two previous healthy children. Results The median serum fetuin-A levels of group I, II, and III were 59.45, 62.73, and 44.52, respectively (p=.065). Serum fetuin-A levels significantly increased in group II compared to group III (p=.011). No significant differences in the levels of fetuin-A of group I compared to either group II (p=.433) or group III (p=.268). Conclusions The etiology of RPL is still a subject that is not clarified. Fetuin-A levels may have a relationship with RPL. [ABSTRACT FROM AUTHOR]

Published
2022
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37. Newborn Hearing Screening Results of Infants Born To Mothers Who Had COVID-19 Disease During Pregnancy: A Retrospective Cohort Study

Author

Oskovi-Kaplan, Z. Asli, primary, Ozgu-Erdinc, A. Seval, additional, Buyuk, Gul Nihal, additional, Sert-Dinc, U. Yasemin, additional, Ali-Algan, Cavide, additional, Demir, Bariş, additional, Sahin, Dilek, additional, Keskin, H. Levent, additional, Tayman, Cüneyt, additional, and Moraloglu-Tekin, Özlem, additional

Published
2021
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39. Reduced Trabecular Bone Score is Associated with Non-Vertebral Fractures and Nephrolithiasis in Transfusion-Dependent Thalassemia.

Author

Kaplan Z., Trinh A., Herath M., Wong P., Milat F., Punchihewa N., Kaplan Z., Trinh A., Herath M., Wong P., Milat F., and Punchihewa N.

Abstract

Although hypercalciuria, osteoporosis, fractures and nephrolithiasis are well described in thalassemia, there is limited literature to guide clinical surveillance of the renal-bone disease in this group. Bone mineral density as assessed by dual-energy x-ray absorptiometry (DXA) is cannot adequately capture the microarchitectural changes seen in thalassaemia bone disease. The trabecular bone score (TBS), derived from the lumbar spine using DXA provides a surrogate measures of bone microarchitecture. There is limited information available on the utility of TBS for fracture risk assessment in the thalassemia cohort. In this cross-sectional study of 71 subjects with transfusion-dependent thalassemia, the relationship between TBS, BMD, fractures, nephrolithiasis and biochemical parameters were investigated. TBS was significantly associated with non-vertebral fractures (OR 1.99 [95% CI 1.28 - 3.09]) and nephrolithiasis (OR 1.98 [1.33, 2.95]). Nephrolithiasis was highly prevalent (40.6%) and common in men (60%). Conventional DXA parameters were not significantly associated with nephrolithiasis but were associated with all types of fracture. This study demonstrates the potential use of TBS in predicting non-vertebral fractures and nephrolithiasis in transfusion-dependent thalassemia. The association between TBS and nephrolithiasis deserves further study.

Published
2021

40. Relationship between myocardial T2*, hepatic T2* and biventricular function from cardiac MRI performed on patients with thalassaemia.

Author

Lin S., Kaplan Z., Nandurkar D., Lin S., Kaplan Z., and Nandurkar D.

Abstract

Purpose: Retrospective study assessing the relationship between myocardial T2*, hepatic T2* and ejection fraction from cardiac MRs performed on thalassaemia patients. The aim was to determine whether abnormalities in LVEF/RVEF can occur in the absence of abnormal myocardial T2* values, determine a threshold level below which the ejection fraction is reduced and evaluate the relationship between hepatic T2* and ejection fraction. Methods and Materials: All cardiac MRIs performed on thalassaemia patients between January 2010 to February 2021 were included. Studies performed on non-thalassaemia patients, studies degraded by significant artefact, incomplete dataset or clinical trial studies were excluded. Baseline patient data, cardiac T2*, hepatic T2*, LVEF and RVEF were recorded. LVEF less than 55% and RVEF less than 45% were considered below normal values. Myocardial T2* < 20 ms and hepatic T2* < 6.3 ms were considered significant for iron loading. Result(s): 857 cardiac MRIs were performed on 269 thalassaemia patients over 11 years. The prevalence of myocardial iron loading was 11%, compared with 40% hepatic iron loading. Only a few patients with iron loading had abnormal LVEF (5) or RVEF (2). There was no significant correlation between severity of myocardial loading and reduced LVEF in patients with T2* < 20 ms. There was no significant difference in median LVEF between loaded (67%) and nonloaded patients (68%). Of the 761 patients with normal myocardial T2*, 21 demonstrated reduced LVEF and 13 reduced RVEF. The majority had normal function on echocardiogram. The remainder were explained by prior iron loading, dilated cardiomyopathy or other significant cardiac history. None of the patients with normal myocardial T2* had newly impaired ventricular function due to iron loading. A threshold below which ejection fraction is predicted to occur could not be determined. No significant relationship was identified between hepatic T2* and ejection fraction. Only 55 of the

Published
2021

41. Inherited Thrombophilias Are Associated with an Increased Risk of COVID-19 Associated Venous Thromboembolism: A Prospective Population-Based Cohort Study.

Author

Stevens H.P., Canovas R., Peter K., Tran H., Kaplan Z., McFadyen J.D., Stevens H.P., Canovas R., Peter K., Tran H., Kaplan Z., and McFadyen J.D.

Abstract

Background: COVID-19 is associated with high rates of venous thromboembolism (VTE). The impact of common inherited thrombophilias on the development of COVID-19-associated VTE (COVID-19 VTE) is not well understood. Objective(s): To determine if the presence of inherited thrombophilias modifies the risk of COVID-19 VTE or COVID-19 mortality. Method(s): Prospective population-based cohort study evaluating adult participants of the UK Biobank diagnosed with COVID-19 between November 2019 and May 2021. Individuals were of European descent and aged between 45 and 69 at recruitment to UK Biobank. We evaluated six single nucleotide polymorphisms including rs6025 (Factor V Leiden mutation) and rs1799963 (Prothrombin mutation) in addition to two polygenic risk scores (PRS-VTE and PRS-ABO). A genome-wide association study was performed for associations with COVID-19 VTE. COVID-19 VTE was defined using International Classification of Diseases and Related Health Problems, Tenth Revision (ICD-10) codes for VTE following COVID-19 diagnosis. COVID-19 mortality was defined using ICD-10 codes for COVID-19 on the death certificate. Result(s): Demographic and clinical characteristics are shown in Table 1. Of the 13 712 COVID-19 positive individuals included in the analysis, the median age was 54 years and 52.5% were female. There were 197 (1.4%) cases of COVID-19 VTE and 890 (6.5%) died due to COVID-19. The rs6025 variant, synonymous with FVL, was associated with a 1.8-fold risk of COVID-19 VTE (95% CI 1.040-2.931) (Table 2). The risk of COVID-VTE was also increased with rs2066865 (OR 1.345; 95% CI 1.074-1.675) and the PRS-VTE (OR 1.262; 95% CI 1.081-1.468) (Table 2). COVID-19 VTE was associated with increased COVID-19 mortality (OR 2.731; 95% CI 1.885-3.901) but this study found no association between the studied inherited thrombophilias and COVID-19 mortality (Table 2). On genome-wide analysis, two novel SNPs, rs4975019 and rs2875853, located on chromosomes 4 and 16 respectively, we

Published
2021

42. Phase I/II updated safety and efficacy results of oral bruton tyrosine kinase (BTK) inhibitor rilzabrutinib in relapsed/refractory immune thrombocytopenia (ITP).

Author

Kuter D.J., Tzvetkov N., Efraim M., Kaplan Z., Mayer J., Choi P., Jansen A., McDonald V., Baker R., Bird R., Garg M., Gumulec J., Kostal M., Gernsheimer T., Ghanima W., Bandman O., Arora P., Burns R., Guo H., Iqbal F., Thomas D., Neale A., Tran Q., Cooper N., Kuter D.J., Tzvetkov N., Efraim M., Kaplan Z., Mayer J., Choi P., Jansen A., McDonald V., Baker R., Bird R., Garg M., Gumulec J., Kostal M., Gernsheimer T., Ghanima W., Bandman O., Arora P., Burns R., Guo H., Iqbal F., Thomas D., Neale A., Tran Q., and Cooper N.

Abstract

Background: Immune thrombocytopenia (ITP) is characterized by immune-mediated platelet destruction and impaired production, triggering thrombocytopenia, and a predisposition to bleeding. Despite recent therapeutic advances, durable remission remains an unmet need for relapsed/refractory ITP patients. Rilzabrutinib is an oral, reversible, covalent inhibitor of BTK that targets immune-mediated ITP activities and has simultaneous rapid anti-inflammatory effects and neutralization and prevention of autoantibody signaling preclinically. The ongoing phase I/II study (NCT03395210) assesses the safety and efficacy of rilzabrutinib in patients with relapsed or refractory ITP who previously responded to >=1 prior ITP therapy and have no available treatment options. Initial results have shown rapid and durable clinical activity and a well-tolerated safety profile in patients responding to rilzabrutinib. Aim(s): Phase II evaluation of rilzabrutinib in the overall study population and patients initiating 400 mg BID rilzabrutinib. Method(s): Eligible patients with 2 baseline platelet counts <30x109/L received oral rilzabrutinib at starting doses of 200 mg QD, 400 mg QD, 300 mg BID, or 400 mg BID; intrapatient dose escalation was allowed to improve efficacy. Rilzabrutinib was given for 24 weeks; additional long-term therapy was administered at the 400 mg BID dose in responders only. Stable doses of concomitant ITP medication (corticosteroids and thrombopoietin-receptor agonists) were permitted for patients without adequate platelet response. The primary endpoints are safety and >=2 consecutive platelet counts >=50x109/L and increased >=20x109/L from baseline without requiring rescue medication. All patients provided informed consent. Result(s): The overall study population comprises 59 patients, of whom 44 had a starting dose of 400 mg BID; data cutoff was 09Nov2020. Overall, patients had a median age 50 years (range, 21-74), median duration of ITP 6.4 years (range, 0.4-52.5), and

Published
2021

43. Phase i/ii ongoing study of rilzabrutinib, an oral bruton tyrosine kinase inhibitor, in immune thrombocytopenia: EXTENDED follow-up and long-term analyses with optimal dose.

Author

Kuter D.J., Tzvetkov N., Efraim M., Kaplan Z., Mayer J., Choi P., Jansen A.J.G., McDonald V., Baker R., Bird R., Garg M., Gumulec J., Kostal M., Gernsheimer T., Ghanima W., Bandman O., Arora P., Tran Q., Guo H., Cooper N., Kuter D.J., Tzvetkov N., Efraim M., Kaplan Z., Mayer J., Choi P., Jansen A.J.G., McDonald V., Baker R., Bird R., Garg M., Gumulec J., Kostal M., Gernsheimer T., Ghanima W., Bandman O., Arora P., Tran Q., Guo H., and Cooper N.

Abstract

Background: For most ITP patients, durable remission remains elusive and their disease becomes refractory to current treatments. Rilzabrutinib, an oral, reversible, covalent BTK inhibitor, targets mechanisms of platelet destruction. Preliminary phase I/II results in ITP showed rilzabrutinib was efficacious and safe at all dose levels, including the optimal 400 mg BID dose (NCT03395210). Aim(s): Assess efficacy/safety of rilzabrutinib with longer follow-up at 400 mg BID and in long-term extension (LTE). Method(s): Eligible patients had 2 baseline platelet counts <30x109/L. Concomitant ITP therapy was permitted at stable doses. Primary endpoints: safety and >=2 consecutive platelet counts >=50x109/L and increased >=20x109/L from baseline without requiring rescue medication. All patients provided informed consent. Result(s): As of 09Nov2020 in 59 patients, 44 initiated rilzabrutinib 400 mg BID and to date, 14 patients with durable, stable response proceeded to LTE at 400 mg BID. For patients initiating rilzabrutinib 400 mg BID, baseline median age was 49 y, median prior therapies: 5.5 (range, 1-53 25% prior splenectomy), and median platelet count: 16x109/L. 39% of patients initiating rilzabrutinib 400 mg BID achieved the primary endpoint at a median of 20.6 weeks (range, 1.4-24.6) on treatment (Table 1) 50% had platelet counts >=30x109/L by day 8. Platelet responses to rilzabrutinib were observed irrespective of prior treatment or responses. LTE patients received rilzabrutinib for a median of 55.9 weeks (range, 13.9-84.3). All LTE patients achieved the primary endpoint response in the main treatment period and maintained platelet counts >=50x109/L for 96% of the LTE (Figure 1). Treatment-related emergent adverse events were all grade 1/2, most commonly diarrhea and nausea, with no related bleeding/thrombotic events. Conclusion(s): Rilzabrutinib 400 mg BID showed rapid and durable responses and was well-tolerated with longer follow-up and in LTE. This ongoing study cont

Published
2021

44. 426. Phase I/II Ongoing Study of Rilzabrutinib, an Oral Bruton Tyrosine Kinase Inhibitor, in Immune Thrombocytopenia: Extended Follow‐up and Long‐term Analyses with Optimal Dose

Author

Kuter, D.J., Tzvetkov, N., Efraim, M., Kaplan, Z., Mayer, J., Choi, P., Jansen, A.J.G., McDonald, V., Baker, R., Bird, R., Garg, M., Gumulec, J., Kostal, M., Gernsheimer, T., Ghanima, W., Bandman, O., Arora, P., Tran, Q., Guo, H., Cooper, N., Kuter, D.J., Tzvetkov, N., Efraim, M., Kaplan, Z., Mayer, J., Choi, P., Jansen, A.J.G., McDonald, V., Baker, R., Bird, R., Garg, M., Gumulec, J., Kostal, M., Gernsheimer, T., Ghanima, W., Bandman, O., Arora, P., Tran, Q., Guo, H., and Cooper, N.

Abstract

Background: For most ITP patients, durable remission remains elusive and their disease becomes refractory to current treatments. Rilzabrutinib, an oral, reversible, covalent BTK inhibitor, targets mechanisms of platelet destruction. Preliminary phase I/II results in ITP showed rilzabrutinib was efficacious and safe at all dose levels, including the optimal 400 mg BID dose (NCT03395210). Aims: Assess efficacy/safety of rilzabrutinib with longer follow‐up at 400 mg BID and in long‐term extension (LTE). Methods: Eligible patients had 2 baseline platelet counts <30×109/L. Concomitant ITP therapy was permitted at stable doses. Primary endpoints: safety and ≥2 consecutive platelet counts ≥50×109/L and increased ≥20×109/L from baseline without requiring rescue medication. All patients provided informed consent. Results: As of 09Nov2020 in 59 patients, 44 initiated rilzabrutinib 400 mg BID and to date, 14 patients with durable, stable response proceeded to LTE at 400 mg BID. For patients initiating rilzabrutinib 400 mg BID, baseline median age was 49 y, median prior therapies: 5.5 (range, 1‐53; 25% prior splenectomy), and median platelet count: 16×109/L. 39% of patients initiating rilzabrutinib 400 mg BID achieved the primary endpoint at a median of 20.6 weeks (range, 1.4‐24.6) on treatment (Table 1); 50% had platelet counts ≥30×109/L by day 8. Platelet responses to rilzabrutinib were observed irrespective of prior treatment or responses. LTE patients received rilzabrutinib for a median of 55.9 weeks (range, 13.9‐84.3). All LTE patients achieved the primary endpoint response in the main treatment period and maintained platelet counts ≥50×109/L for 96% of the LTE (Figure 1). Treatment‐related emergent adverse events were all grade 1/2, most commonly diarrhea and nausea, with no related bleeding/thrombotic events. Conclusions: Rilzabrutinib 400 mg BID showed rapid and durable responses and was well‐tolerated with longer follow‐up and in LTE. This ongoing study continues to as

Published
2021

45. Pladias Database of the Czech flora and vegetation. Pladias – databáze české flóry a vegetace

Author

Chytrý, M., Danihelka, J., Kaplan, Z., Wild, J., Holubová, D., Novotný, P., Řezníčková, M., Rohn, M., Dřevojan, P., Grulich, V., Klimešová, J., Lepš, J., Lososová, Z., Pergl, J., Sádlo, J., Šmarda, P., Štěpánková, P., Tichý, L., Axmanová, I., Bartušková, A., Blažek, P., Chrtek jun., J., Fischer, F.M., Guo, W.-Y., Herben, T., Janovský, Z., Konečná, M., Kühn, Ingolf, Moravcová, L., Petřík, P., Pierce, S., Prach, K., Prokešová, H., Štech, M., Těšitel, J., Těšitelová, T., Večeřa, M., Zelený, D., Pyšek, P., Chytrý, M., Danihelka, J., Kaplan, Z., Wild, J., Holubová, D., Novotný, P., Řezníčková, M., Rohn, M., Dřevojan, P., Grulich, V., Klimešová, J., Lepš, J., Lososová, Z., Pergl, J., Sádlo, J., Šmarda, P., Štěpánková, P., Tichý, L., Axmanová, I., Bartušková, A., Blažek, P., Chrtek jun., J., Fischer, F.M., Guo, W.-Y., Herben, T., Janovský, Z., Konečná, M., Kühn, Ingolf, Moravcová, L., Petřík, P., Pierce, S., Prach, K., Prokešová, H., Štech, M., Těšitel, J., Těšitelová, T., Večeřa, M., Zelený, D., and Pyšek, P.

Abstract

The Pladias (Plant Diversity Analysis and Synthesis) Database of the Czech Flora and Vegetation was developed by the Pladias project team in 2014–2018 and has been continuously updated since then. The flora section of the database contains critically revised information on the Czech vascular flora, including 13.6 million plant occurrence records, which are dynamically displayed in maps, and data on 120 plant characteristics (traits, environmental associations and other information), divided into the sections: (1) Habitus and growth type, (2) Leaf, (3) Flower, (4) Fruit, seed and dispersal, (5) Belowground organs and clonality, (6) Trophic mode, (7) Karyology, (8) Taxon origin, (9) Ecological indicator values, (10) Habitat and sociology, (11) Distribution and frequency, and (12) Threats and protection. The vegetation section of the database contains information on Czech vegetation types extracted from the monograph Vegetation of the Czech Republic. The data are supplemented by national botanical bibliographies, electronic versions of the standard national flora and vegetation monographs, a database of more than 19,000 pictures of plant taxa and vegetation types, and digital maps (shapefiles) with botanical information. The data from the database are available online on a public portal www.pladias.cz, which also provides download options for various datasets and online identification keys to the species and vegetation types of the Czech Republic. In this paper, we describe the general scope, structure and content of the database, and details of the data on plant characteristics. To illustrate the data and describe the main geographic patterns in selected plant characteristics, we provide maps of mean values of numerical characteristics or proportions of categories for categorical characteristics on the map of the country in a grid of 5 longitudinal × 3 latitudinal minutes (approximately 6.0 km × 5.5 km). We also summarize the main variation patterns in the functional

Published
2021

47. TRY plant trait database – enhanced coverage and open access

Author

Kattge, J., Bonisch, G., Diaz, S., Lavorel, S., Prentice, I. C., Leadley, P., Tautenhahn, S., Werner, G. D. A., Aakala, T., Abedi, M., Acosta, A. T. R., Adamidis, G. C., Adamson, K., Aiba, M., Albert, C. H., Alcantara, J. M., Alcazar, C C., Aleixo, I., Ali, H., Amiaud, B., Ammer, C., Amoroso, M. M., Anand, M., Anderson, C., Anten, N., Antos, J., Apgaua, D. M. G., Ashman, T. L., Asmara, D. H., Asner, G. P., Aspinwall, M., Atkin, O., Aubin, I., Baastrup-Spohr, L., Bahalkeh, K., Bahn, M., Baker, T., Baker, W. J., Bakker, J. P., Baldocchi, D., Baltzer, J., Banerjee, A., Baranger, A., Barlow, J., Barneche, D. R., Baruch, Z., Bastianelli, D., Battles, J., Bauerle, W., Bauters, M., Bazzato, E., Beckmann, M., Beeckman, H., Beierkuhnlein, C., Bekker, R., Belfry, G., Belluau, M., Beloiu, M., Benavides, R., Benomar, L., Berdugo-Lattke, M. L., Berenguer, E., Bergamin, R., Bergmann, J., Bergmann Carlucci, M., Berner, L., Bernhardt Romermann, M., Bigler, C., Bjorkman, A. D., Blackman, C., Blanco, C., Blonder, B., Blumenthal, D., Bocanegra Gonzalez, K. T., Boeckx, P., Bohlman, S., Bohning Gaese, K., Boisvert Marsh, L., Bond, W., Bond-Lamberty, B., Boom, A., Boonman, C. C. F., Bordin, K., Boughton, E. H., Boukili, V., Bowman, D. M. J. S., Bravo, S., Brende, l M. R., Broadley, M. R., Brown, K. A., Bruelheide, H., Brumnich, F., Bruun, H. H., Bruy, D., Buchanan, S. W., Bucher, S. F., Buchmann, N., Buitenwerf, R., Bunker, D. E., Burge, r J., Burrascano, S., Burslem, D. F. R. P., Butterfield, B. J., Byun, C., Marques, M., Scalon, M. C., Caccianiga, M., Cadotte, M., Cailleret, M., Camac, J., Camarero, J. J., Campany, C., Campetella, G., Campos, J. A., Cano Arboleda, L., Canullo, R., Carbognani, M., Carvalho, F., Casanoves, F., Castagneyrol, B., Catford, J. A., Cavender Bares, J., Cerabolini, B. E. L., Cervellini, M., Chacon Madrigal, E., Chapin, K., Chapin, F. S., Chelli, S., Chen, S. C., Chen, A., Cherubini, P., Chianucci, F., Choat, B., Chung, K. S., Chytry, M., Ciccarelli, D., Coll, L., Collins, C. G., Conti, L., Coomes, D., Cornelissen, J. H. C., Cornwell, W. K., Corona, P., Coyea, M., Craine, J., Craven, D., Cromsigt, J. P. G. M., Csecserits, A., Cufar, K., Cuntz, M., da Silva, A. C., Dahlin, K. M., Dainese, M., Dalke, I., Dalle Fratte, M., Dang Le, A. T., Danihelka, J., Dannoura, M., Dawson, S., de Beer, A. J., De Frutos, A., De Long, J. R., Dechant, B., Delagrange, S., Delpierre, N., Derroire, G., Dias, A. S., Diaz Toribio, M. H., Dimitrakopoulos, P. G., Dobrowolski, M., Doktor, D., Drevojan, P., Dong, N., Dransfield, J., Dressler, S., Duarte, L., Ducouret, E., Dullinger, S., Durka, W., Duursma, R., Dymova, O., E- Vojtko, A., Eckstein, R. L., Ejtehadi, H., Elser, J., Emilio, T., Engemann, K., Erfanian, M. B., Erfmeier, A., Esquivel Muelbert, A., Esser, G., Estiarte, M., Domingues, T. F., Fagan, W. F., Fagundez, J., Falster, D. S., Fan, Y., Fang, J., Farris, E., Fazlioglu, F., Feng, Y., Fernandez, Mendez, Ferrara, C., Ferreira, J., Fidelis, A., Finegan, B., Firn, J., Flowers, T. J., Flynn, D. F. B., Fontana, V., Forey, E., Forgiarini, C., Francois, L., Frangipani, M., Frank, D., Frenette Dussault, C., Freschet, G. T., Fry, E. L., Fyllas, N. M., Mazzochini, G. G., Gachet, S., Gallagher, R., Ganade, G., Ganga, F., Garcia Palacios, P., Gargaglione, V., Garnier, E., Garrido, J. L., de Gasper, A. L., Gea Izquierdo, G., Gibson, D., Gillison, A. N., Giroldo, A., Glasenhardt, M. C., Gleason, S., Gliesch, M., Goldberg, E., Goldel, B., Gonzalez Akre, E., Gonzalez Andujar, J. L., Gonzalez Melo, A., Gonzalez Robles, A., Graae, B. J., Granda, E., Graves, S., Green, W. A., Gregor, T., Gross, N., Guerin, G. R., Gunther, A., Gutierrez, A. G., Haddock, L., Haines, A., Hall, J., Hambuckers, A., Han, W., Harrison, S. P., Hattingh, W., Hawes, J. E., He, T., He, P., Heberling, J. M., Helm, A., Hempel, S., Hentschel, J., Herault, B., Heres, A. M., Herz, K., Heuertz, M., Hickler, T., Hietz, P., Higuchi, P., Hipp, A. L., Hirons, A., Hock, M., Hogan, J. A., Holl, K., Honnay, O., Hornstein, D., Hou, E., Hough Snee, N., Hovstad, K. A., Ichie, T., Igic, B., Illa, E., Isaac, M., Ishihara, M., Ivanov, L., Ivanova, L., Iversen, C. M., Izquierdo, J., Jackson, R. B., Jackson, B., Jactel, H., Jagodzinsk, A. M., Jandt, U., Jansen, S., Jenkins, T., Jentsch, A., Jespersen, J. R. P., Jiang, G. F., Johansen, J. L., Johnson, D., Jokela, E. J., Joly, C. A., Jordan, G. J., Joseph, G. S., Junaedi, D., Junker, R. R., Justes, E., Kabzems, R., Kane, J., Kaplan, Z., Kattenborn, T., Kavelenova, L., Kearsley, E., Kempel, A., Kenzo, T., Kerkhoff, A., Khalil, M. I., Kinlock, N. L., Kissling, W. D., Kitajima, K., Kitzberger, T., Kjoller, R., Klein, T., Kleyer, M., Klimesova, J., Klipel, J., Kloeppel, B., Klotz, S., Knops, J. M. H., Kohyama, T., Koike, F., Kollmann, J., Komac, B., Komatsu, K., Konig, C., Kraft, N. J. B., Kramer, K., Kreft, H., Kuhn, I., Kumarathune, D., Kuppler, J., Kurokawa, H., Kurosawa, Y., Kuyah, S., Laclau, J. P., Lafleur, B., Lallai, E., Lamb, E., Lamprecht, A., Larkin, D. J., Laughlin, D., Le Bagousse Pinguet, Y., le Maire, G., le Roux, P. C., le Roux, E., Lee, T., Lens, F., Lewis, S. L., Lhotsky, B., Li, Y., Li, X., Lichstein, J. W., Liebergesell, M., Lim, J. Y., Lin, Y. S., Linares, Y. C., Liu, C., Liu, D., Liu, U., Livingstone, S., Llusia, J., Lohbeck, M., Lopez Garcia, A., Lopez Gonzalez, G., Lososov, a Z., Louault, F., Lukacs, B. A., Lukes, P., Luo, Y., Lussu, M., Ma, S., Maciel Rabelo Pereira, C., Mack, M., Maire, V., Makela, A., Makinen, H., Malhado, A. C. M., Mallik, A., Manning, P., Manzoni, S., Marchetti, Z., Marchino, L., Marcilio Silva, V., Marcon, E., Marignani, M., Markesteijn, L., Martin, A., Martinez Garza, C., Martinez Vilalta, J., Maskova, T., Mason, K., Mason, N., Massad, T. J., Masse, J., Mayrose, I., Mccarthy, J., Mccormack, M. L., Mcculloh, K., Mcfadden, I., Mcgill, B. J., Mcpartland, M. Y., Medeiros, J., Medlyn, B., Meerts, P., Mehrabi, Z., Meir, P., Melo, F., P. L., Mencuccini, M., Meredieu, C., Messier, J., Meszaros, I., Metsaranta, J., Michaletz, S. T., Michelaki, C., Migalina, S., Milla, R., Miller, J., E. D., Minden, V., Ming, R., Mokany, K., Moles, A. T., Molnar, A., Molofsky, J., Molz, M., Montgomery, R. A., Monty, A., Moravcova, L., Moreno Martinez, A., Moretti, M., Mori, A. S., Mori, S., Morris, D., Morrison, J., Mucina, L., Mueller, S., Muir, C. D., Muller, S. C., Munoz, F., Myers Smith, I. H., Myster, R. W., Nagano, M., Naidu, S., Narayanan, A., Natesan, B., Negoita, L., Nelson, A. S., Neuschulz, E. L., Ni, J., Niedrist, G., Nieto, J., Niinemets, U., Nolan, R., Nottebrock, H., Nouvellon, Y., Novakovskiy, A., Nystuen, K. O., O'Grady, A., O'Hara, K., O'Reilly Nugent, A., Oakley, S., Oberhuber, W., Ohtsuka, T., Oliveira, R., Ollerer, K., Olson, M. E., Onipchenko, V., Onoda, Y., Onstein, R. E., Ordonez, J. C., Osada, N., Ostonen, I., Ottaviani, G., Otto, S., Overbeck, G. E., Ozinga, W. A., Pahl, A. T., Paine, C. E. T., Pakeman, R. J., Papageorgiou, A. C., Parfionova, E., Partel, M., Patacca, M., Paula, S., Paule, J., Pauli, H., Pausas, J., Peco, B., Penuelas, J., Perea, A., Peri, P. L., Petisco Souza, A. C., Petraglia, A., Petritan, A. M., Phillips, O. L., Pierce, S., Pillar, V. D., Pisek, J., Pomogaybin, A., Poorter, H., Portsmuth, A., Poschlod, P., Potvin, C., Pounds, D., Powell, A., Power, S. A., Prinzing, A., Puglielli, G., Pysek, P., Raevel, V., Rammig, A., Ransijn, J., Ray, C. A., Reich, P. B., Reichstein, M., Reid, D. E. B., Rejou Mechain, M., de Dios, V. R., Ribeiro, S., Richardson, S., Riibak, K., Rillig, M. C., Riviera, F., Robert, E. M. R., Roberts, S., Robroek, B., Roddy, A., Rodrigues, A. V., Rogers, A., Rollinson, E., Rolo, V., Romermann, C., Ronzhina, D., Roscher, C., Rosell, J. A., Rosenfield, M. F., Rossi, C., Roy, D. B., Royer Tardif, S., Ruger, N., Ruiz Peinado, R., Rumpf, S. B., Rusch, G. M., Ryo, M., Sack, L., Saldana, A., Salgado Negret, B., Salguero Gomez, R., Santa Regina, I., Santacruz Garcia, A. C., Santos, J., Sardans, J., Schamp, B., Scherer Lorenzen, M., Schleuning, M., Schmid, B., Schmidt, M., Schmitt, S., Schneider, J. V., Schowanek, S. D., Schrader, J., Schrodt, F., Schuldt, B., Schurr, F., Selaya Garvizu, G., Semchenko, M., Seymour, C., Sfair, J. C., Sharpe, J. M., Sheppard, C. S., Sheremetiev, S., Shiodera, S., Shipley, B., Shovon, T. A., Siebenkas, A., Sierra, C., Silva, V., Silva, M., Sitzia, T., Sjoman, H., Slot, M., Smith, N. G., Sodhi, D., Soltis, P., Soltis, D., Somers, B., Sonnier, G., Sorensen, M. V., Sosinski, E. E., Soudzilovskaia, N. A., Souza, A. F., Spasojevic, M., Sperandii, M. G., Stan, A. B., Stegen, J., Steinbauer, K., Stephan, J. G., Sterck, F., Stojanovic, D. B., Strydom, T., Suarez, M. L., Svenning, J. C., Svitkova, I., Svitok, M., Svoboda, M., Swaine, E., Swenson, N., Tabarelli, M., Takagi, K., Tappeiner, U., Tarifa, R., Tauugourdeau, S., Tavsanoglu, C., te Beest, M., Tedersoo, L., Thiffault, N., Thom, D., Thomas, E., Thompson, K., Thornton, P. E., Thuiller, W., Tichy, L., Tissue, D., Tjoelker, M. G., Tng, D. Y. P., Tobias, J., Torok, P., Tarin, T., Torres Ruiz, J. M., Tothmeresz, B., Treurnicht, M., Trivellone, V., Trolliet, F., Trotsiuk, V., Tsakalos, J. L., Tsiripidis, I., Tysklind, N., Umehara, T., Usoltsev, V., Vadeboncoeur, M., Vaezi, J., Valladares, F., Vamosi, J., van Bodegom, P. M., van Breugel, M., Van Cleemput, E., van de Weg, M., van der Merwe, S., van der Plas, F., van der Sande, M. T., van Kleunen, M., Van Meerbeek, K., Vanderwel, M., Vanselow, K. A., Varhammar, A., Varone, L., Vasquez Valderrama, M. Y., Vassilev, K., Vellend, M., Veneklaas, E. J., Verbeeck, H., Verheyen, K., Vibrans, A., Vieira, I., Villacis, J., Violle, C., Vivek, P., Wagner, K., Waldram, M., Waldron, A., Walker, A . P., Waller, M., Walther, G., Wang, H., Wang, F., Wang, W., Watkins, H., Watkins, J., Weber, U., Weedon, J. T., Wei, L., Weigelt, P., Weiher, E., Wells, A. W., Wellstein, C., Wenk, E., Westoby, M., Westwood, A., White, P. J., Whitten, M., Williams, M., Winkler, D. E., Winter, K., Womack, C., Wright, I. J., Wright, S. J., Wright, J., Pinho, B. X., Ximenes, F., Yamada, T., Yamaji, K., Yanai, R., Yankov, N., Yguel, B., Zanini, K. J., Zanne, A. E., Zeleny, D., Zhao, Y. P., Zheng, J., Zieminska, K., Zirbel, C. R., Zizka, G., Zo Bi, I. C., Zotz, G., Wirth, C., Systèmes d'élevage méditerranéens et tropicaux (UMR SELMET), Centre de Coopération Internationale en Recherche Agronomique pour le Développement (Cirad)-Institut National de la Recherche Agronomique (INRA)-Centre international d'études supérieures en sciences agronomiques (Montpellier SupAgro)-Institut national d’études supérieures agronomiques de Montpellier (Montpellier SupAgro), Institut national d'enseignement supérieur pour l'agriculture, l'alimentation et l'environnement (Institut Agro)-Institut national d'enseignement supérieur pour l'agriculture, l'alimentation et l'environnement (Institut Agro), Laboratoire de Physique et Physiologie Intégratives de l’Arbre en environnement Fluctuant - Clermont Auvergne (PIAF), Université Clermont Auvergne (UCA)-Institut National de la Recherche Agronomique (INRA), Botanique et Modélisation de l'Architecture des Plantes et des Végétations (UMR AMAP), Institut de Recherche pour le Développement (IRD [France-Sud])-Centre de Coopération Internationale en Recherche Agronomique pour le Développement (Cirad)-Institut National de la Recherche Agronomique (INRA)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS), Biodiversité, Gènes & Communautés (BioGeCo), Institut National de la Recherche Agronomique (INRA)-Université de Bordeaux (UB), SILVA (SILVA), AgroParisTech-Université de Lorraine (UL)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Ecologie des forêts de Guyane (UMR ECOFOG), Centre de Coopération Internationale en Recherche Agronomique pour le Développement (Cirad)-Institut National de la Recherche Agronomique (INRA)-AgroParisTech-Université de Guyane (UG)-Centre National de la Recherche Scientifique (CNRS)-Université des Antilles (UA), Unité Mixte de Recherche sur l'Ecosystème Prairial - UMR (UREP), Institut National de la Recherche Agronomique (INRA)-VetAgro Sup - Institut national d'enseignement supérieur et de recherche en alimentation, santé animale, sciences agronomiques et de l'environnement (VAS), Ecologie fonctionnelle et biogéochimie des sols et des agro-écosystèmes (UMR Eco&Sols), Centre de Coopération Internationale en Recherche Agronomique pour le Développement (Cirad)-Institut de Recherche pour le Développement (IRD)-Institut National de la Recherche Agronomique (INRA)-Centre international d'études supérieures en sciences agronomiques (Montpellier SupAgro)-Institut national d’études supérieures agronomiques de Montpellier (Montpellier SupAgro), Unité Expérimentale Forêt Pierroton (UEFP), Institut National de la Recherche Agronomique (INRA), Max Planck Institute for Biogeochemistry Max Planck SocietyFoundation CELLEX German Centre for Integrative Biodiversity Research (iDiv) Halle-Jena-Leipzig International Programme of Biodiversity Science (DIVERSITAS) International Geosphere-Biosphere Programme (IGBP) French Foundation for Biodiversity Research (FRB) GIS 'Climat, Environnement et Societe' France AXA Research Fund NERC Natural Environment Research Council Future Earth, Max Planck Institute for Biogeochemistry (MPI-BGC), Max-Planck-Gesellschaft, German Centre for Integrative Biodiversity Research (iDiv), Instituto Multidisciplinario de Biología Vegetal [Córdoba] (IMBIV), Consejo Nacional de Investigaciones Científicas y Técnicas [Buenos Aires] (CONICET)-Facultad de Ciencias Exactas, Físicas y Naturales [Córdoba], Universidad Nacional de Córdoba [Argentina]-Universidad Nacional de Córdoba [Argentina], Laboratoire d'Ecologie Alpine (LECA ), Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry])-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes (UGA), Imperial College London, Ecologie Systématique et Evolution (ESE), AgroParisTech-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS), Department of Zoology [Oxford], University of Oxford, Balliol College, Helsingin yliopisto = Helsingfors universitet = University of Helsinki, Tarbiat Modares University [Tehran], Università degli Studi Roma Tre = Roma Tre University (ROMA TRE), Department of Environment [Aegean], University of the Aegean, Institute of Ecology and Evolution [Bern, Switzerland], University of Bern, University of Tartu, Tohoku University [Sendai], Institut méditerranéen de biodiversité et d'écologie marine et continentale (IMBE), Avignon Université (AU)-Aix Marseille Université (AMU)-Institut de recherche pour le développement [IRD] : UMR237-Centre National de la Recherche Scientifique (CNRS), Universidad de Jaén (UJA), Instituto Alexander Von Humboldt, Bogota, Colombia, National Institute of Amazonian Research (INPA), Manaus, Brazil, Botany Department, Faculty of Science, Suez Canal University, Ismailia, Egypt, Laboratoire Agronomie et Environnement - Antenne Colmar (LAE-Colmar ), Laboratoire Agronomie et Environnement (LAE), Université de Lorraine (UL)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Université de Lorraine (UL)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Forest Sciences, University of Göttingen, Göttingen, Germany, Centre for Biodiversity and Sustainable Land-use [University of Göttingen] (CBL), Georg-August-University = Georg-August-Universität Göttingen, Instituto de Investigaciones en Recursos Naturales, Agroecología y Desarrollo Rural (IRNAD), Universidad Nacional de Río Negro, El Bolsón, Argentina, Consejo Nacional de Investigaciones Científicas y Técnicas [Buenos Aires] (CONICET), School of Environmental Sciences, University of Guelph, Pacific Northwest National Laboratory, Richland, WA, USA, University of Massachusetts [Amherst] (UMass Amherst), University of Massachusetts System (UMASS), Centre for Crop Systems Analysis, Wageningen University and Research [Wageningen] (WUR), University of Victoria [Canada] (UVIC), College of Science & Engineering, James Cook University, Smithfield, Qld, Australia, University of Pittsburgh, Pittsburgh, PA, USA, Centre for Forest Research, Institute for Integrative Systems Biology, Université Laval, Quebec, QC, Canada, Arizona State University, Tempe, AZ, USA, University of North Florida [Jacksonville] (UNF), Australian National University (ANU), Great Lakes Forestry Centre, Canadian Forest Service, Natural Resources Canada, Sault Ste. Marie, ON, Canada, Department of Biology [Copenhagen], Faculty of Science [Copenhagen], University of Copenhagen = Københavns Universitet (UCPH)-University of Copenhagen = Københavns Universitet (UCPH), Department of Ecology [Innsbruck], Leopold Franzens Universität Innsbruck - University of Innsbruck, University of Leeds, Royal Botanic Gardens Kew, Richmond, UK, Conservation Ecology, Groningen Institute for Evolutionary Life Sciences (GELIFES), University of Groningen, Groningen, The Netherlands, Lawrence Berkeley National Laboratory [Berkeley] (LBNL), Biology Department, Wilfrid Laurier University, Waterloo, ON, Canada, Department of Forest Resources, University of Minnesota, St. Paul, MN, USA, AgroParisTech, Lancaster Environment Centre, Lancaster University, University of Exeter, University of Adelaide, Centre de Coopération Internationale en Recherche Agronomique pour le Développement (Cirad)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Institut Agro - Montpellier SupAgro, Département Environnements et Sociétés (Cirad-ES), Centre de Coopération Internationale en Recherche Agronomique pour le Développement (Cirad), University of California [Berkeley] (UC Berkeley), University of California (UC), Department of Horticulture and Landscape Architecture, Colorado State University, Fort Collins, CO, USA, Universiteit Gent = Ghent University (UGENT), Università degli Studi di Cagliari = University of Cagliari (UniCa), Helmholtz Zentrum für Umweltforschung = Helmholtz Centre for Environmental Research (UFZ), Royal Museum for Central Africa, Tervuren, Belgium, Bayreuth Center of Ecology and Environmental Research (BayCEER), Groningen Institute of Archaeology (GIA), University of Groningen, Groningen, The Netherlands, Department of Biological Sciences, University of Tennessee, Knoxville, TN, USA, Rocky Mountain Biological Laboratory, Crested Butte, CO, USA, Département des Science, Université du Québec À Montréal, Montreal, QC, Canada, Department of Biogeography, University of Bayreuth, Bayreuth, Germany, Museo Nacional de Ciencias Naturales [Madrid] (MNCN), Consejo Superior de Investigaciones Científicas [Madrid] (CSIC), Université Laval, Quebec, QC, Canada, Instituto de Ciencias Naturales, Universidad Nacional de Colombia, Bogota, Colombia, Fundación Natura, Bogota, Colombia, Environmental Change Institute, Laboratório de Estudos em Vegetação Campestre (LEVCamp), Programa de Pós-Graduação em Botânica, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil, Freie Universität Berlin, Berlin-Brandenburg Institute of Advanced Biodiversity Research (BBIB), Berlin, Germany, Laboratório de Ecologia Funcional de Comunidades (LABEF), Departamento de Botânica, Universidade Federal do Paraná, Curitiba, Brazil, School of Informatics, Computing, and Cyber Systems (SICCS), Northern Arizona University [Flagstaff], Institute of Ecology and Evolution, Friedrich Schiller University Jena, Jena, Germany, ETH Zurich, Universitatstrasse 16, 8092 Zurich, Switzerland, University of Gothenburg (GU), Laboratoire de Physique et Physiologie Intégratives de l’Arbre en environnement Fluctuant (PIAF), Université Clermont Auvergne [2017-2020] (UCA [2017-2020])-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Universidade Federal do Rio Grande do Sul [Porto Alegre] (UFRGS), School of Life Sciences, Arizona State University, Tempe, AZ, USA, USDA-ARS Rangeland Resources & Systems Research Unit, Fort Collins, CO, USA, Grupo de Investigación en Biodiversidad y Dinámica de Ecosistémas Tropicales - Universidad del Tolima, Ibagué, Colombia, Laboratory of Applied Physical Chemistry - ISOFYS (Gent, Belgium), School of Forest Resources and Conservation [Gainesville] (UF|IFAS|FFGS), Institute of Food and Agricultural Sciences [Gainesville] (UF|IFAS), University of Florida [Gainesville] (UF)-University of Florida [Gainesville] (UF), Senckenberg Biodiversity and Climate Research Centre, Frankfurt am Main, Germany, Department of Biological Sciences, Goethe Universität Frankfurt, Frankfurt am Main, Germany, Department of Biological Sciences, University of Cape Town, Cape Town, South Africa, SAEON Fynbos Node, Claremont, South Africa, Pacific Northwest National Laboratory, College Park, MD, USA, University of Leicester, Department of Environmental Science, Institute for Water and Wetland Research, Radboud University, Nijmegen, The Netherlands, Laboratório de Ecologia Vegetal (LEVEG), Programa de Pós-Graduação em Ecologia, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil, Archbold Biological Station’s Buck Island Ranch, FL, Lake Placid, USA, Department of Ecology and Evolutionary Biology, University of Connecticut, Storrs, CT, USA, University of Tasmania [Hobart, Australia] (UTAS), Facultad de Ciencias Forestales, Universidad Nacional de Santiago del Estero, Santiago del Estero, Argentina, Universität Hohenheim, School of Geography, University of Nottingham, Nottingham, UK, Department of Geography and Geology, Kingston University, Kingston upon Thames, UK, Martin-Luther-Universität Halle Wittenberg (MLU), Facultad de Ingeniería y Ciencias Hídricas, Universidad Nacional del Litoral (FICH-UNL), Santa Fe, Argentina, Centre de Coopération Internationale en Recherche Agronomique pour le Développement (Cirad)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD [France-Sud])-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Institut de Recherche pour le Développement (IRD [Nouvelle-Calédonie]), University of Toronto at Scarborough, Friedrich-Schiller-Universität = Friedrich Schiller University Jena [Jena, Germany], Section for Ecoinformatics and Biodiversity, Department of Bioscience, Aarhus University, Aarhus, Denmark, Center for Biodiversity Dynamics in a Changing World (BIOCHANGE), Department of Bioscience, Aarhus University, Aarhus, Denmark, New Jersey Institute of Technology [Newark] (NJIT), University of Rostock, Università degli Studi di Roma 'La Sapienza' = Sapienza University [Rome] (UNIROMA), School of Biological Sciences, University of Aberdeen, Aberdeen, UK, Center for Ecosystem Science and Society, Northern Arizona University, Flagstaff, AZ, USA, School of Civil and Environmental Engineering, Yonsei University, Seoul, Korea, Departamento de Botânica, SCB, UFPR – Federal University of Parana, Curitiba, Brazil, Centro Politécnico, Universidade Federal do Paraná, Curitiba, Brazil, Università degli Studi di Milano = University of Milan (UNIMI), Risques, Ecosystèmes, Vulnérabilité, Environnement, Résilience (RECOVER), Aix Marseille Université (AMU)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Department of Environmental Systems Science, ETH Zürich, Zürich, Switzerland, Swiss Federal Institute for Forest, Snow and Landscape Research WSL, Centre of Excellence for Bioscurity Risk Analysis, The University of Melbourne, Melbourne, Vic., Australia, Centro de Investigaciones Biológicas (CSIC), Colgate University, Hamilton, NY, USA, School of Biosciences and Veterinary Medicine, Plant Diversity and Ecosystems Management Unit, University of Camerino, Camerino, Italy, University of the Basque Country/Euskal Herriko Unibertsitatea (UPV/EHU), Departamento de Geociencias y Medio Ambiente, Universidad Nacional de Colombia, Medellin, Colombia, Università degli studi di Parma = University of Parma (UNIPR), Centro Agronómico Tropical de Investigación y Enseñanza - Tropical Agricultural Research and Higher Education Center (CATIE), Université de Bordeaux (UB)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Department of Geography, King’s College London, London, UK, University of Minnesota [Twin Cities] (UMN), University of Minnesota System, Universitá degli Studi dell’Insubria = University of Insubria [Varese] (Uninsubria), Alma Mater Studiorum Università di Bologna [Bologna] (UNIBO), Universidad de Costa Rica (UCR), University of Arizona, Institute of Arctic Biology, University of Alaska [Fairbanks] (UAF), Royal Botanic Gardens [Kew], Department of Biology [Fort Collins], Colorado State University [Fort Collins] (CSU), WSL Swiss Federal Research Institute, Birmensdorf, Switzerland, Faculty of Forestry, University of British Columbia, Vancouver, BC, Canada, CREA – Research Centre for Forestry and Wood, Arezzo, Italy, Western Sydney University, ungwon University, Goesan, Chungbuk, Korea, Department of Botany and Zoology [Brno] (SCI / MUNI), Faculty of Science [Brno] (SCI / MUNI), Masaryk University [Brno] (MUNI)-Masaryk University [Brno] (MUNI), University of Pisa - Università di Pisa, Department of Agriculture and Forest Engineering (EAGROF), University of Lleida, Lleida, Spain, Joint Research Unit CTFC – AGROTECNIO, Solsona, Spain, University of California Riverside, Riverside, CA, USA, Faculty of Environmental Sciences, University of Life Sciences Prague, Institute of Botany of the Czech Academy of Sciences (IB / CAS), Czech Academy of Sciences [Prague] (CAS), University of Cambridge [UK] (CAM), Systems Ecology, Department of Ecological Science, Vrije Universiteit, Amsterdam, The Netherlands, School of Biological, Earth and Environmental Sciences, UNSW Sydney, Sydney, NSW, Australia, Faculté de foresterie, de géographie et de géomatique, Université Laval, Quebec, QC, Canada, Jonah Ventures, Boulder, CO, USA, Centro de Modelación y Monitoreo de Ecosistemas, Universidad Mayor, Santiago, Chile, Department of Wildlife, Fish and Environmental Studies, Swedish University of Agricultural Sciences (SLU), Centre for African Conservation Ecology, Department of Zoology, Nelson Mandela University, Port Elizabeth, South Africa, MTA Centre for Ecological Research [Tihany], Hungarian Academy of Sciences (MTA), University of Ljubljana, Santa Catarina State University, Lages, SC, Brazil, Department of Geography, Environment, and Spatial Sciences, Michigan State University, East Lansing, MI, USA, Eurac Research, Institute for Alpine Environment, Bozen-Bolzano, Italy, Institute of Biology of Komi Science Centre of the Ural Branch of the Russian Academy of Sciences, Syktyvkar, Komi Republic, Russia, University of Science – Vietnam National University Ho Chi Minh City, Ho Chi Minh City, Vietnam, Graduate School of Agriculture, Kyoto University, Kyoto, Japan, Graduate School of Global Environmental Studies, Kyoto University, Kyoto, Japan, Swedish Species Information Centre, University of Pretoria [South Africa], Helmholtz Centre for Environmental Research – UFZ, Leipzig, Germany, Department of Terrestrial Ecology, Netherlands Institute of Ecology, Wageningen, The Netherlands, Department Computational Landscape Ecology [UFZ Leipsig], Department Computational Hydrosystems, UFZ – Helmholtz Centre for Environmental Research, Leipzig, Germany, Seoul National University [Seoul] (SNU), Institute of Temperate Forest Sciences (ISFORT), Ripon, QC, Canada, UQO, Department of Natural Sciences, Ripon, QC, Canada, Université Paris-Sud - Paris 11 (UP11)-AgroParisTech-Centre National de la Recherche Scientifique (CNRS), Centre de Coopération Internationale en Recherche Agronomique pour le Développement (Cirad)-AgroParisTech-Université de Guyane (UG)-Centre National de la Recherche Scientifique (CNRS)-Université des Antilles (UA)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Goethe-Universität Frankfurt am Main, University of Florida [Gainesville] (UF), The University of Western Australia (UWA), School of Biological Sciences, The University of Western Australia, Department of Biological Sciences, Macquarie University, Department of Botany and Molecular Evolution, Senckenberg Research Institute and Natural History Museum, Universität Wien, Karlstad University [Sweden], Ferdowsi University of Mashhad (FUM), Flathead Lake Biological Station, University of Montana, School of Sustainability, Arizona State University, Programa Nacional de Pós-Doutorado (PNPD), Programa de Pós Graduação em Ecologia, Institute of Biology, University of Campinas UNICAMP, Institute for Ecosystem Research/Geobotany, Kiel University, School of Geography, Earth and Environmental Sciences [Birmingham], University of Birmingham [Birmingham], Justus-Liebig-Universität Gießen = Justus Liebig University (JLU), Global Ecology Unit CREAF-CEAB-CSIC, Universitat Autònoma de Barcelona (UAB), FFCLRP-USP, Department of Biology [USA], University of Maryland [College Park], University of Maryland System-University of Maryland System, University of A Coruña (UDC), School of Physics [UNSW Sydney] (UNSW), University of New South Wales [Sydney] (UNSW), Icahn School of Medicine at Mount Sinai [New York] (MSSM), University of Peking, Peking University [Beijing], Università degli Studi di Sassari = University of Sassari [Sassari] (UNISS), Ordu University - Ordu Üniversitesi, Lanzhou University, Universidad del Tolima, Research Centre for Forestry and Wood, Consiglio per la Ricerca in Agricoltura e l’analisi dell’economia agraria = Council for Agricultural Research and Economics (CREA), Brazilian Agricultural Research Corporation (Embrapa), Universidade de São Paulo = University of São Paulo (USP), Centro Agronomico Tropical de Investigacion y Ensenanza (CATIE), Queensland University of Technology [Brisbane] (QUT), University of Sussex, Harvard University, Institute for Alpine Environment, European Academy of Bozen-Bolzano (EURAC), Étude et compréhension de la biodiversité (ECODIV), Université de Rouen Normandie (UNIROUEN), Normandie Université (NU)-Normandie Université (NU), Laboratoire de Physique Atmosphérique et Planétaire (LPAP), Université de Liège, Université de Sherbrooke (UdeS), Station d'écologie théorique et expérimentale (SETE), Université Toulouse III - Paul Sabatier (UT3), Université de Toulouse (UT)-Université de Toulouse (UT)-Observatoire Midi-Pyrénées (OMP), Institut de Recherche pour le Développement (IRD)-Université Toulouse III - Paul Sabatier (UT3), Université de Toulouse (UT)-Université de Toulouse (UT)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National d'Études Spatiales [Toulouse] (CNES)-Centre National de la Recherche Scientifique (CNRS)-Météo-France -Institut de Recherche pour le Développement (IRD)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National d'Études Spatiales [Toulouse] (CNES)-Centre National de la Recherche Scientifique (CNRS)-Météo-France -Centre National de la Recherche Scientifique (CNRS), Centre d’Ecologie Fonctionnelle et Evolutive (CEFE), Université Paul-Valéry - Montpellier 3 (UPVM)-École Pratique des Hautes Études (EPHE), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD [France-Sud])-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Institut Agro - Montpellier SupAgro, University of Manchester [Manchester], Universidade Estadual de Campinas = University of Campinas (UNICAMP), Macquarie University, Universidade Federal do Rio Grande do Norte [Natal] (UFRN), Universidad Rey Juan Carlos [Madrid] (URJC), Universidad Nacional de la Patagonia Austral (UNPA), Universidade Regional de Blumenau (FURB), INIA-CIFOR, Southern Illinois University [Carbondale] (SIU), Center for Biodiversity Management, Instituto Federal de Educação Ciência e Tecnologia do Cearà, The Morton Arboretum, United States Department of Agriculture (USDA), Swiss Federal Institute of Technology, Aarhus University [Aarhus], Smithsonian Conservation Biology Institute, Centre Supérieur de la Recherche Scientifique (CSIC), Centre Supérieur de la Recherche Scientifique, Universidad del Rosario [Bogota], Norwegian University of Science and Technology [Trondheim] (NTNU), Norwegian University of Science and Technology (NTNU), Université Paris Sud (Paris 11), Senckenberg Research Institutes and Natural History Museums, Universidad de Chile = University of Chile [Santiago] (UCHILE), Joint Global Change Research Institute, Pacific Northwest National Laboratory (PNNL)-University of Maryland [College Park], Smithsonian Tropical Research Institute, University of Liege, Université de Liège - Gembloux, Institut Pasteur de Shanghai, Académie des Sciences de Chine - Chinese Academy of Sciences (IPS-CAS), Réseau International des Instituts Pasteur (RIIP), University of Bristol [Bristol], University of the Witwatersrand [Johannesburg] (WITS), Norwegian University of Life Sciences (NMBU), Murdoch University, Carnegie Museum of Natural History [Pittsburgh], Transilvania University of Brasov, Martin-Luther-University Halle-Wittenberg, Senckenberg Biodiversity and Climate Research Centre (SBiK-F), Goethe-Universität Frankfurt am Main-Senckenberg – Leibniz Institution for Biodiversity and Earth System Research - Senckenberg Gesellschaft für Naturforschung, Leibniz Association-Leibniz Association, Universität für Bodenkultur Wien = University of Natural Resources and Life [Vienne, Autriche] (BOKU), Santa Catarina State University (UDESC), University Centre Myerscough, Kiel University, Florida International University [Miami] (FIU), Division of Plant Ststematic and Ecology, Biology department, Université Catholique de Louvain = Catholic University of Louvain (UCL), University of Applied Sciences of Weihenstephan, Four Peaks Environmental Science and Data Solutions, Norsk institutt for bioøkonomi=Norwegian Institute of Bioeconomy Research (NIBIO), Kochi University of Technology (KUT), University of Illinois [Chicago] (UIC), University of Illinois System, Universitat de Barcelona (UB), Kyoto University, Tyumen State University, Oak Ridge National Laboratory [Oak Ridge] (ORNL), UT-Battelle, LLC, Universitat Politècnica de Catalunya [Barcelona] (UPC), Stanford University, University of Edinburgh, Polish Academy of Sciences (PAN), Philips Research Europe - Hamburg, Sector Medical Imaging Systems, Philips Research, Institute for Systematic Botany and Ecology, Universität Ulm - Ulm University [Ulm, Allemagne], Ecosystèmes, biodiversité, évolution [Rennes] (ECOBIO), Université de Rennes (UR)-Institut Ecologie et Environnement (INEE), Centre National de la Recherche Scientifique (CNRS)-Centre National de la Recherche Scientifique (CNRS)-Observatoire des Sciences de l'Univers de Rennes (OSUR), Université de Rennes (UR)-Institut national des sciences de l'Univers (INSU - CNRS)-Université de Rennes 2 (UR2)-Centre National de la Recherche Scientifique (CNRS)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Institut national des sciences de l'Univers (INSU - CNRS)-Université de Rennes 2 (UR2)-Centre National de la Recherche Scientifique (CNRS)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Centre National de la Recherche Scientifique (CNRS), Universität Bayreuth, University of Copenhagen = Københavns Universitet (UCPH), Guangxi Normal University, University College of London [London] (UCL), Hobart - Tasmania 7001, University of Venda [South Africa] (UNIVEN), University of Melbourne, Philipps Universität Marburg = Philipps University of Marburg, Agrosystèmes Cultivés et Herbagers (ARCHE), Institut National de la Recherche Agronomique (INRA)-École nationale supérieure agronomique de Toulouse (ENSAT), Institut National Polytechnique (Toulouse) (Toulouse INP), Université de Toulouse (UT)-Université de Toulouse (UT)-Institut National Polytechnique (Toulouse) (Toulouse INP), Université de Toulouse (UT)-Université de Toulouse (UT), Natural Resource Operations and Rural Development, Humboldt State University (HSU), Charles University [Prague] (CU), Karlsruhe Institute of Technology (KIT), Samara National Research University, Institute of Plant Sciences, Forestry and Forest Products Research Institute (FFPRI), Kenyon College, University of Garmian, State University of New York (SUNY), Institute for Biodiversity and Ecosystem Dynamics (IBED), University of Amsterdam [Amsterdam] (UvA), Universidad Nacional del Comahue [Neuquén] (UNCOMA), IT University of Copenhagen (ITU), Agricultural Research Organization, Landscape Ecology Group, University of Oldenburg, Western Carolina University, Xi'an Jiaotong-Liverpool University [Suzhou], Hokkaido University [Sapporo, Japan], Yokohama National University, Technische Universität Munchen - Université Technique de Munich [Munich, Allemagne] (TUM), Institut d Estudis Andorrans, Smithsonian Environmental Research Center (SERC), Humboldt University Of Berlin, University of California [Los Angeles] (UCLA), Department of Biodiversity, Macroecology and Biogeography, Yamagata University, Jomo Kenyatta University of Agriculture and Technology (JKUAT), Centre de Coopération Internationale en Recherche Agronomique pour le Développement (Cirad)-Institut de Recherche pour le Développement (IRD)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Institut Agro - Montpellier SupAgro, Université du Québec en Abitibi-Témiscamingue (UQAT), University of Saskatchewan [Saskatoon] (U of S), University of Natural Resources and Life Sciences, Institute of Mountain Risk Engineering - Vienna, Austria, University of Wyoming (UW), Département Performances des systèmes de production et de transformation tropicaux (Cirad-PERSYST), Nelson Mandela University [Port Elizabeth], University of Wisconsin - Eau Claire, Naturalis Biodiversity Center [Leiden], Département de biologie [Sherbrooke] (UdeS), Faculté des sciences [Sherbrooke] (UdeS), Université de Sherbrooke (UdeS)-Université de Sherbrooke (UdeS), Yangzhou University, Leipzig University, University Pablo de Olavide, Shanghai Jiao Tong University [Shanghai], Royal Botanical Gardens, Masaryk University [Brno] (MUNI), Department of Physiology, University of Debrecen Egyetem [Debrecen]-Research Centre for Molecular Medicine-Medical and Health Science Centre, Global Change Research Centre (CzechGlobe), Université du Québec à Trois-Rivières (UQTR), Natural Resources Institute Finland (LUKE), Universidade Federal de Alagoas = Federal University of Alagoas (UFAL), Lakehead University, Stockholm University, Universidad Nacional del Litoral [Santa Fe] (UNL), Universidade Federal do Paraná (UFPR), Bangor University, Universidad Autonoma del Estado de Morelos (UAEM), Manaaki Whenua – Landcare Research [Lincoln], Gorongosa National Park, Université de Montréal (UdeM), Tel Aviv University (TAU), University of Queensland [Brisbane], University of Wisconsin-Madison, University of Maine, Holden Arboretum, Hawkesbury Institute for he Environment, Laboratoire d'Ecologie Végétale et Biogéochimie, Université libre de Bruxelles (ULB), University of British Columbia (UBC), Research School of Biology, Universidade Federal de Pernambuco [Recife] (UFPE), School of Geosciences [Edinburgh], Ecology and Evolutionary Biology [Tucson] (EEB), University of Debrecen, Northern Forestry Centre, Canadian Forest Service - CFS (CANADA), University of Illinois at Urbana-Champaign [Urbana], Data61 [Canberra] (CSIRO), Australian National University (ANU)-Commonwealth Scientific and Industrial Research Organisation [Canberra] (CSIRO), University of Debrecen Egyetem [Debrecen], University of Vermont [Burlington], Fundação Zoobotânica do Rio Grande do Sul, University of Montana, Institut de RadioAstronomie Millimétrique (IRAM), Centre National de la Recherche Scientifique (CNRS), University of Freiburg [Freiburg], University of Hawaii, Institut Français de Pondichéry (IFP), Ministère de l'Europe et des Affaires étrangères (MEAE)-Centre National de la Recherche Scientifique (CNRS), Oklahoma State University [Stillwater] (OSU), Osaka City University, Charles Darwin Research Station (CDRS), Charles Darwin Foundation, Los Alamos National Laboratory (LANL), Zhejiang Normal University, European Academy of Bolzano, Universidad Distrital Francisco Jose de Caldas [Bogota], University of Bayreuth, Institute of Biology of Komi Scientific Centre of the Ural Branch of the Russian Academy of Sciences, Russian Academy of Sciences [Moscow] (RAS), CSIRO Land and Water, Commonwealth Scientific and Industrial Research Organisation [Canberra] (CSIRO), University of Canberra, CEH, Department of Systems and Science, Graduate School of Informatics, Kyoto University-Kyoto University, Departamento de Telemática, Faculdade de Engenharia Elétrica e de Computação (DT/FEEC), Universidad Nacional Autónoma de México = National Autonomous University of Mexico (UNAM), Moscow State University, Vrije Universiteit Amsterdam [Amsterdam] (VU), Meijo University, Institute of Ecology and Earth Sciences [Tartu], Astronomical Institute of the Czech Academy of Sciences (ASU / CAS), University of Nijmegen, University of New England (UNE), The James Hutton Institute, Democritus University of Thrace (DUTH), Institute of Ecology and Earth Sciences, University of Tartu, Spanish National Research Council (CSIC), Senckenberg Research Institute and Natural History Museum, University of Vienna [Vienna], Center for Desertification Research (CIDE), Universitat de València (UV), Universidad Autónoma de Madrid (UAM), Université de Jaén, National Institute for Research and Development in Forestry, Department of Plant Production (University of Milan), Tartu Observatory, Botanical Garden of the Samara University, Forschungszentrum Jülich GmbH, Tallinn University, Universität Regensburg (REGENSBURG), Universität Regensburg, School of Social Sciences [Cardiff], Cardiff University, Estonian University of Life Sciences (EMU), Sch Life Sci Weihenstephan, Arizona State University [Tempe] (ASU), Department of Forest Resources, University of Minnesota System-University of Minnesota System, Research Institute for Networks and Communications Engineering (RINCE), Dublin City University [Dublin] (DCU)-Science Foundation Ireland-Enterprise Ireland-Higher Education Authority-School of Electronic Engineering, Southwest University of Science and Technology [Mianyang] (SWUST), Universidade Federal do Acre (UFAC), Berlin-Brandenburg Institute of Advanced Biodiversity Research (BBIB), Centre méditérannéen de médecine moléculaire (C3M), Université Nice Sophia Antipolis (1965 - 2019) (UNS), COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Institut National de la Santé et de la Recherche Médicale (INSERM), Mississippi State University [Mississippi], University of Southampton, Yale University [New Haven], Brookhaven National Laboratory [Upton, NY] (BNL), UT-Battelle, LLC-Stony Brook University [SUNY] (SBU), State University of New York (SUNY)-State University of New York (SUNY)-U.S. Department of Energy [Washington] (DOE), East Stroudsburg University, INDEHESA, Forestry School, Universidad de Extremadura - University of Extremadura (UEX), Institute of Physical Geography [Frankfurt am Main], Universität Zürich [Zürich] = University of Zurich (UZH), Lake Ecosystems Group [Lancaster, U.K.] (Centre for Ecology & Hydrology), Lancaster Environment Centre [Lancaster, U.K.], University of Valladolid, Norwegian Institute for Nature Research (NINA), Universidad Nacional de Colombia [Bogotà] (UNAL), Instituto de Recursos Naturales y Agrobiología de Salamanca (IRNASA), Universidade de Coimbra [Coimbra], Algoma University, Senckenberg biodiversität und klima forschungszentrum (BIK-F), Forschungsinstitut Senckenberg (SGN), University of Nottingham, UK (UON), University of Würzburg = Universität Würzburg, Agence Française de Sécurité Sanitaire des Aliments (AFSSA), Herencia, Kirstenbosch Research Centre, South African National Biodiversity Institute, Federal University of Pernambuco [Recife], Sharplex Services, University of Hohenheim, Komarov Botanical Institute RAS, Center for Sustainability Science, Hokkaido, Département de Biologie, University of Regina (UR), Technische Universität Ilmenau (TU ), Universidade de Lisboa = University of Lisbon (ULISBOA), Universidade Federal de Lavras = Federal University of Lavras (UFLA), Università degli Studi di Padova = University of Padua (Unipd), Gothenburg Global Biodiversity Centre, Department of Biology [Gainesville] (UF|Biology), Texas Tech University [Lubbock] (TTU), Florida Museum of Natural History [Gainesville], KU Leuven, Embrapa Recursos Genéticos e Biotecnologia [Brasília], Universiteit Leiden, University of California [Riverside] (UC Riverside), Pacific Northwest National Laboratory (PNNL), University of Natural Resources and Applied Life Sciences, Vienna, (BOKU) and Competence Centre Wood K plus, University of Novi Sad, Instituto Nacional de Investigaciones en Biodiversidad y Medioambiente [Bariloche] (INIBIOMA-CONICET), Consejo Nacional de Investigaciones Científicas y Técnicas [Buenos Aires] (CONICET)-Universidad Nacional del Comahue [Neuquén] (UNCOMA), Slovak Academy of Sciences (SAS), Technical University in Zvolen (TUZVO), Faculty of Forestry and Wood Sciences, Czech University of Life Sciences Prague (CZU), University of Aberdeen, University of Maryland System, Universität Innsbruck [Innsbruck], Estacion Experimental de Zonas Aridas, Hacettepe University = Hacettepe Üniversitesi, Centre for Forest Research (CFR), Université du Québec à Montréal = University of Québec in Montréal (UQAM), Bioversity International [Montpellier], Bioversity International [Rome], Consultative Group on International Agricultural Research [CGIAR] (CGIAR)-Consultative Group on International Agricultural Research [CGIAR] (CGIAR), Department of Animal and Plant Sciences [Sheffield], University of Sheffield [Sheffield], The School for Field Studies, Quantum Optics and Laser Science, Blackett Laboratory, Blackett Laboratory, Imperial College London-Imperial College London, University of Delaware [Newark], Université Clermont Auvergne [2017-2020] (UCA [2017-2020]), Biodiversity and Ecosystem Services Research Group, Stellenbosch University, Czech University of Life Science, Aristotle University of Thessaloniki, Osaka Natural History Center, Ural State Forest Engineering University, University of New Hampshire (UNH), University of Calgary, Catholic University of Leuven - Katholieke Universiteit Leuven (KU Leuven), Hawkesbury Institute for the Environment [Richmond] (HIE), Computational & Applied Vegetation Ecology (CAVElab), Dept Forest & Water Management, Lab Forestry, Museu Paraense Emílio Goeldi, Federal University of Para - Universidade Federal do Pará - UFPA [Belém, Brazil] (UFPA), State Key Laboratory of Natural and Biomimetic Drugs, Fudan University [Shanghai], Department of Ecological Science [Amsterdam], Vrije Universiteit Brussel (VUB), Laboratoire de Biologie des Ligneux et des Grandes Cultures (LBLGC), Université d'Orléans (UO)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Department of Biology, Free University of Bozen-Bolzano, Dpt Biological Sciences, Macquarie University, Duke University [Durham], IFP Energies nouvelles (IFPEN), Department of Primary Industries, Graduate School of Integrated Arts and Sciences, Hiroshima University, Université de Tsukuba = University of Tsukuba, SUNY College of Environmental Science and Forestry (SUNY-ESF), Biological Sciences Department (BIOLOGICAL SCIENCES DEPARTMENT), Nanjing University (NJU), National Taiwan University [Taiwan] (NTU), Zhejiang University, Beijing Forestry University, Institut National Polytechnique Félix Houphouët-Boigny, Universität Leipzig, Max Planck Fellow Program for Christian Wirth, the International Programme of Biodiversity Science (DIVERSITAS), the International Geosphere‐Biosphere Programme (IGBP), Future Earth, the French Foundation for Biodiversity Research (FRB), and GIS ‘Climat, Environnement et Société’ France, JENS KATTGE, MAX PLANCK INSTITUTE FOR BIOGEOCHEMISTRY, GERMANY, ELLEN L. FRY, UNIVERSITY OF LIÈGE, BELGIUM, NIKOLAOS M. FYLLAS, UNIVERSITY OF THE AEGEAN, GREECE, GERHARD BÖNISCH, MAX PLANCK INSTITUTE FOR BIOGEOCHEMISTRY, GERMANY, SUSANNE TAUTENHAHN, MAX PLANCK INSTITUTE FOR BIOGEOCHEMISTRY, JENA, GERMANY, GIJSBERT D. A. WERNER, UNIVERSITY OF OXFORD, OXFORD, UK, TUOMAS AAKALA, UNIVERSITY OF HELSINKI, FINLAND, MEHDI ABEDI, TARBIAT MODARES UNIVERSITY, IRAN, ALICIA T. R. ACOSTA, UNIVERSITY OF ROMA TRE, ITALY, GEORGE C. ADAMIDIS, UNIVERSITY OF BERN, SWITZERLAND, KAIRI ADAMSON, UNIVERSITY OF TARTU, ESTONIA, MASAHIRO AIBA, TOHOKU UNIVERSITY, JAPAN., CÉCILE H. ALBERT, AIX MARSEILLE UNIV, UNIV AVIGNON, FRANCE., JULIO M. ALCÁNTARA, UNIVERSIDAD DE JAÉN, SPAIN, CAROLINA ALCÁZAR C, Instituto Alexander Von Humboldt, Colombia., HAMADA ALI, SUEZ CANAL UNIVERSITY, EGYPT, BERNARD AMIAUD, UNIVERSITÉ DE LORRAINE, FRANCE., CHRISTIAN AMMER, UNIVERSITY OF GÖTTINGEN, GERMANY, MARIANO M. AMOROSO, UNIVERSIDAD NACIONAL DE RÍO NEGRO, ARGENTINA, MADHUR ANAND, UNIVERSITY OF GUELPH, CANADA., MARIJN BAUTERS, GHENT UNIVERSITY, BELGIUM., ERIKA BAZZATO, UNIVERSITY OF CAGLIARI, ITALY., MICHAEL BECKMANN, Helmholtz Centre for Environmental Research, Germany., HANS BEECKMAN, ROYAL MUSEUM FOR CENTRAL AFRICA, BELGIUM., CARL BEIERKUHNLEIN, UNIVERSITY OF BAYREUTH, GERMANY., RENEE BEKKER, UNIVERSITY OF GRONINGEN, THE NETHERLANDS., JOANA BERGMANN, FREIE UNIVERSITÄT BERLIN, GERMANY., MARCOS BERGMANN CARLUCCI, UFPC, LOGAN BERNER, NORTHERN ARIZONA UNIVERSITY, USA., MARKUS BERNHARDT-RÖMERMANN, FRIEDRICH SCHILLER UNIVERSITY JENA, GERMANY., CHRISTOF BIGLER, ETH ZURICH, SWITZERLAND., FEDERICO BRUMNICH, UNIVERSIDAD NACIONAL DEL LITORAL (FICH-UNL), ARGENTINA, HANS HENRIK BRUUN, UNIVERSITY OF COPENHAGEN, DENMARK, DAVID BRUY, UNIVERSITÉ DE MONTPELLIER, FRANCE, SERRA W. BUCHANAN, UNIVERSITY OF TORONTO SCARBOROUGH, CANADA, ROBERT BUITENWERF, AARHUS UNIVERSITY, DENMARK, DANIEL E. BUNKER, NEW JERSEY INSTITUTE OF TECHNOLOGY, USA, JANA BÜRGER, UNIVERSITY OF ROSTOCK, GERMANY, SABINA BURRASCANO, SAPIENZA UNIVERSITY OF ROME, ITALY, DAVID F. R. P. BURSLEM, UNIVERSITY OF ABERDEEN, UK, BRADLEY J. BUTTERFIELD, NORTHERN ARIZONA UNIVERSITY, USA, CHAEHO BYUN, YONSEI UNIVERSITY, KOREA, MARINA C. SCALON, UFP, MARCO CACCIANIGA, UNIVERSITÀ DEGLI STUDI DI MILANO, ITALY, MARC CADOTTE, UNIVERSITY OF TORONTO SCARBOROUGH, CANADA, MAXIME CAILLERET, AIX?MARSEILLE UNIVERSITY, FRANCE, JAMES CAMAC, THE UNIVERSITY OF MELBOURNE, AUSTRALIA, JESÚS JULIO CAMARERO, INSTITUTO PIRENAICO DE ECOLOGÍA (IPE?CSIC), SPAIN, COURTNEY CAMPANY, COLGATE UNIVERSITY, USA, GIANDIEGO CAMPETELLA, UNIVERSITY OF CAMERINO, ITALY, JUAN ANTONIO CAMPOS, UNIVERSITY OF THE BASQUE COUNTRY UPV/EHU, SPAIN, LAURA CANO-ARBOLEDA, UNIVERSIDAD NACIONAL DE COLOMBIA, COLOMBIA, ROBERTO CANULLO, UNIVERSITY OF CAMERINO, ITALY, MICHELE CARBOGNANI, UNIVERSITY OF PARMA, ITALY, FABIO CARVALHO, LANCASTER UNIVERSITY, UK, BASTIEN CASTAGNEYROL, UNIV. BORDEAUX, FRANCE, JANE A. CATFORD, KING'S COLLEGE LONDON, UK, JEANNINE CAVENDER-BARES, UNIVERSITY OF MINNESOTA, USA, BRUNO E. L. CERABOLINI, UNIVERSITY OF INSUBRIA, ITALY, MARCO CERVELLINI, UNIVERSITY OF BOLOGNA, ITALY, EDUARDO CHACÓN-MADRIGAL, UNIVERSIDAD DE COSTA RICA, COSTA RICA, KENNETH CHAPIN, THE UNIVERSITY OF ARIZONA, USA, SAMANTHA DAWSON, SWEDISH UNIVERSITY OF AGRICULTURAL SCIENCES, AREND JACOBUS DE BEER, UNIVERSITY OF PRETORIA, SOUTH AFRICA, ANGEL DE FRUTOS, HELMHOLTZ CENTRE FOR ENVIRONMENTAL RESEARCH, GERMANY, LEANDRO DUARTE, UFRGS, EMILIE DUCOURET, UMR ECOFOG (AGROPARISTECH, CNRS, INRA, UNIVERSITÉ DES ANTILLES, UNIVERSITÉ DE LA GUYANE), FRANCE, STEFAN DULLINGER, UNIVERSITY OF VIENNA, AUSTRIA, DAN F. B. FLYNN, ARNOLD ARBORETUM OF HARVARD UNIVERSITY, USA, VERONIKA FONTANA, INSTITUTE FOR ALPINE ENVIRONMENT, ITALY, KYONG-SOOK CHUNG, JUNGWON UNIVERSITY, KOREA, MILAN CHYTRÝ, MASARYK UNIVERSITY, CZECH REPUBLIC, DANIELA CICCARELLI, UNIVERSITY OF PISA, ITALY, LLUÍS COLL, UNIVERSITY OF LLEIDA, SPAIN, COURTNEY G. COLLINS, UNIVERSITY OF CALIFORNIA RIVERSIDE, USA, LUISA CONTI, UNIVERSITY OF LIFE SCIENCES PRAGUE, CZECH REPUBLIC, DAVID COOMES, UNIVERSITY OF CAMBRIDGE, UK, JOHANNES H. C. CORNELISSEN, VRIJE UNIVERSITEIT, THE NETHERLANDS, WILLIAM K. CORNWELL, EARTH AND ENVIRONMENTAL SCIENCES, AUSTRALIA, PIERMARIA CORONA, CREA – RESEARCH CENTRE FOR FORESTRY AND WOOD, ITALY, MARIE COYEA, UNIVERSITÉ LAVAL, CANADA, JOSEPH CRAINE, JONAH VENTURES, USA, DYLAN CRAVEN, UNIVERSIDAD MAYOR, CHILE, JORIS P. G. M. CROMSIGT, SWEDISH UNIVERSITY OF AGRICULTURAL SCIENCES, SWEDEN, ANIKÓ CSECSERITS, MTA CENTRE FOR ECOLOGICAL RESEARCH, HUNGARY, KATARINA CUFAR, UNIVERSITY OF LJUBLJANA, SLOVENIA, MATTHIAS CUNTZ, UNIVERSITÉ DE LORRAINE, FRANCE, ANA CAROLINA DA SILVA, SANTA CATARINA STATE UNIVERSITY, BRAZIL, KYLA M. DAHLIN, MICHIGAN STATE UNIVERSITY, USA, MATTEO DAINESE, INSTITUTE FOR ALPINE ENVIRONMENT, ITALY, IGOR DALKE, INSTITUTE OF BIOLOGY OF KOMI SCIENCE CENTRE OF THE URAL BRANCH OF THE RUSSIAN ACADEMY OF SCIENCES, RUSSIA, MICHELE DALLE FRATTE, UNIVERSITY OF INSUBRIA, ITALY, ANH TUAN DANG-LE, UNIVERSITY HO CHI MINH CITY, VIETNAM, JIRÍ DANIHELKA, MASARYK UNIVERSITY, CZECH REPUBLIC, MASAKO DANNOURA, KYOTO UNIVERSITY, JAPAN, JONATHAN R. DE LONG, NETHERLANDS INSTITUTE OF ECOLOGY, THE NETHERLANDS, BENJAMIN DECHANT, SEOUL NATIONAL UNIVERSITY, REPUBLIC OF KOREA, SYLVAIN DELAGRANGE, INSTITUTE OF TEMPERATE FOREST SCIENCES (ISFORT), CANADA, NICOLAS DELPIERRE, UNIVERSITY OF PARIS?SUD, FRANCE, GÉRALDINE DERROIRE, UNIVERSITÉ DES ANTILLES, FRANCE, ARILDO S. DIAS, UNIVERSITÄT FRANKFURT, GERMANY, MILTON HUGO DIAZ-TORIBIO, UNIVERSITY OF FLORIDA, USA, PANAYIOTIS G. DIMITRAKOPOULOS, UNIVERSITY OF THE AEGEAN, GREECE, MARK DOBROWOLSKI, THE UNIVERSITY OF WESTERN AUSTRALIA, AUSTRALIA, DANIEL DOKTOR, HELMHOLTZ CENTRE FOR ENVIRONMENTAL RESEARCH – UFZ, GERMANY, PAVEL DREVOJAN, MASARYK UNIVERSITY, CZECH REPUBLIC, NING DONG, MACQUARIE UNIVERSITY, AUSTRALIA, JOHN DRANSFIELD, ROYAL BOTANIC GARDENS KEW, UK, STEFAN DRESSLER, DEPARTMENT OF BOTANY AND MOLECULAR EVOLUTION, GERMANY, WALTER DURKA, GERMAN CENTER FOR INTEGRATIVE BIODIVERSITY RESEARCH (IDIV) HALLE?JENA?LEIPZIG, GERMANY, REMKO DUURSMA, WESTERN SYDNEY UNIVERSITY, AUSTRALIA, OLGA DYMOVA, KOMI REPUBLIC, RUSSIA, E-VOJTKÓ, A., UNIVERSITY OF SOUTH BOHEMIA, CZECH REPUBLIC, ROLF LUTZ ECKSTEIN, KARLSTAD UNIVERSITY, SWEDEN, HAMID EJTEHADI, FERDOWSI UNIVERSITY OF MASHHAD, IRAN, JAMES ELSER, UNIVERSITY OF MONTANA, USA, THAISE EMILIO, UNIVERSITY OF CAMPINAS UNICAMP, BRAZIL, KRISTINE ENGEMANN, AARHUS UNIVERSITY, DENMARK, MOHAMMAD BAGHER ERFANIAN, FERDOWSI UNIVERSITY OF MASHHAD, IRAN, ALEXANDRA ERFMEIER, KIEL UNIVERSITY, KIEL, GERMANY, ADRIANE ESQUIVEL-MUELBERT, EARTH AND ENVIRONMENTAL SCIENCES, AUSTRALIA, GERD ESSER, JUSTUS LIEBIG UNIVERSITY, GERMANY, MARC ESTIARTE, SPANISH NATIONAL RESEARCH COUNCIL – CSIC, SPAIN, TOMAS F. DOMINGUES, DEPARTMENT OF BIOLOGY – FFCLRP/USP, BRAZIL, WILLIAM F. FAGAN, UNIVERSITY OF MARYLAND, USA, JAIME FAGÚNDEZ, UNIVERSITY OF A CORUÑA, SPAIN, DANIEL S. FALSTER, EVOLUTION & ECOLOGY RESEARCH CENTRE, AUSTRALIA, YING FAN, RUTGERS UNIVERSITY, USA, JINGYUN FANG, PEKING UNIVERSITY, CHINA, EMMANUELE FARRIS, UNIVERSITY OF SASSARI, ITALY, FATIH FAZLIOGLU, ORDU UNIVERSITY, TURKEY, YANHAO FENG, LANZHOU UNIVERSITY, CHINA, FERNANDO FERNANDEZ-MENDEZ, UNIVERSIDAD DEL TOLIMA, COLOMBIA, CARLOTTA FERRARA, CREA – RESEARCH CENTRE FOR FORESTRY AND WOOD, ITALY, JOICE NUNES FERREIRA, CPATU, ALESSANDRA FIDELIS, (UNESP), RIO CLARO, BRAZIL, BRYAN FINEGAN, CATIE-CENTRO AGRONÓMICO TROPICAL DE INVESTIGACIÓN Y ENSEÑANZA, COSTA RICA, JENNIFER FIRN, QUEENSLAND UNIVERSITY OF TECHNOLOGY (QUT), AUSTRALIA, TIMOTHY J. FLOWERS, UNIVERSITY OF SUSSEX, UK, ESTELLE FOREY, UNIVERSITÉ DE ROUEN, FRANCE, CRISTIANE FORGIARINI, UFRGS, BRAZIL., LOUIS FRANÇOIS, UNIVERSITY OF LIÈGE, BELGIUM., MARCELO FRANGIPANI, UFRGS, BRAZIL, DOROTHEA FRANK, MAX PLANCK INSTITUTE FOR BIOGEOCHEMISTRY, GERMANY, CEDRIC FRENETTE-DUSSAULT, GÉOPOLE DE L'UNIVERSITÉ DE SHERBROOKE, CANADA, GRÉGOIRE T. FRESCHET, PAUL SABATIER UNIVERSITY TOULOUSE, FRANCE, PAUL LEADLEY, UNIVERSITY OF PARIS-SUD, UNIVERSITÉ PARIS-SACLAY, ORSAY, FRANCE, IZABELA ALEIXO, NATIONAL INSTITUTE OF AMAZONIAN RESEARCH (INPA), BRAZIL, SANDRA DÍAZ, UNIVERSIDAD NACIONAL DE CÓRDOBA, ARGENTINA, SANDRA LAVOREL, UNIV. SAVOIE MONT BLANC, LECA, GRENOBLE, FRANCE, IAIN COLIN PRENTICE, IMPERIAL COLLEGE, UK., CAROLYN ANDERSON, UNIVERSITY OF MASSACHUSETTS AMHERST, USA, NIELS ANTEN, WAGENINGEN UNIVERSITY, THE NETHERLANDS, JOSEPH ANTOS, UNIVERSITY OF VICTORIA, CANADA, DEBORAH MATTOS GUIMARÃES APGAUA, JAMES COOK UNIVERSITY, AUSTRALIA, TIA-LYNN ASHMAN, UNIVERSITY OF PITTSBURGH, USA, DEGI HARJA ASMARA, UNIVERSITÉ LAVAL, CANADA, GREGORY P. ASNER, ARIZONA STATE UNIVERSITY, USA., MICHAEL ASPINWALL, UNIVERSITY OF NORTH FLORIDA, USA., OWEN ATKIN, AUSTRALIAN NATIONAL UNIVERSITY, AUSTRALIA., ISABELLE AUBIN, NATURAL RESOURCES CANADA, LARS BAASTRUP-SPOHR, UNIVERSITY OF COPENHAGEN, DENMARK., KHADIJEH BAHALKEH, TARBIAT MODARES UNIVERSITY, IRAN., MICHAEL BAHN, UNIVERSITY OF INNSBRUCK, AUSTRIA., TIMOTHY BAKER, UNIVERSITY OF LEEDS, LEEDS, UK., WILLIAM J. BAKER, ROYAL BOTANIC GARDENS KEW, UK., JAN P. BAKKER, UNIVERSITY OF GRONINGEN, THE NETHERLANDS., DENNIS BALDOCCHI, UNIVERSITY OF CALIFORNIA BERKELEY, USA., JENNIFER BALTZER, WILFRID LAURIER UNIVERSITY, CANADA, ARINDAM BANERJEE, UNIVERSITY OF MINNESOTA, USA., ANNE BARANGER, AGROPARISTECH, FRANCE., JOS BARLOW, LANCASTER UNIVERSITY, UK., DIEGO R. BARNECHE, UNIVERSITY OF EXETER, UK., ZDRAVKO BARUCH, THE UNIVERSITY OF ADELAIDE, AUSTRALIA., DENIS BASTIANELLI, UNIV MONTPELLIER, FRANCE., JOHN BATTLES, UNIVERSITY OF CALIFORNIA AT BERKELEY, USA, WILLIAM BAUERLE, COLORADO STATE UNIVERSITY, USA, SOLVEIG FRANZISKA BUCHER, FRIEDRICH?SCHILLER?UNIVERSITÄT JENA, GERMANY, GAVIN BELFRY, UNIVERSITY OF TENNESSEE, USA., MICHAEL BELLUAU, UNIVERSITÉ DU QUÉBEC À MONTRÉAL, CANADA., MIRELA BELOIU, UNIVERSITY OF BAYREUTH, GERMANY., RAQUEL BENAVIDES, MUSEO NACIONAL DE CIENCIAS NATURALES-CSIC, SPAIN., LAHCEN BENOMAR, UNIVERSITÉ LAVAL, CANADA., MARY LEE BERDUGO-LATTKE, UNIVERSIDAD NACIONAL DE COLOMBIA, COLOMBIA., ERIKA BERENGUER, UNIVERSITY OF OXFORD, UK., RODRIGO BERGAMIN, UFRS, NINA BUCHMANN, ETH ZURICH, ZURICH, SWITZERLAND, ANNE D. BJORKMAN, UNIVERSITY OF GOTHENBURG, SWEDEN., CHRIS BLACKMAN, UNIVERSITÉ CLERMONT-AUVERGNE, FRANCE., CAROLINA BLANCO, UFRGS, BENJAMIN BLONDER, ARIZONA STATE UNIVERSITY, USA., DANA BLUMENTHAL, USDA-ARS RANGELAND RESOURCES & SYSTEMS RESEARCH UNIT, USA., KELLY T. BOCANEGRA-GONZÁLEZ, UNIVERSIDAD DEL TOLIMA, COLOMBIA., PASCAL BOECKX, GHENT UNIVERSITY, BELGIUM., STEPHANIE BOHLMAN, UNIVERSITY OF FLORIDA, USA., KATRIN BÖHNING-GAESE, UNIVERSITÄT FRANKFURT, GERMANY., LAURA BOISVERT-MARSH, UNIVERSITÄT FRANKFURT, GERMANY., WILLIAM BOND, UNIVERSITY OF CAPE TOWN, SOUTH AFRICA., BEN BOND-LAMBERTY, COLLEGE PARK, USA., ARNOUD BOOM, UNIVERSITY OF LEICESTER, UK., COLINE C. F. BOONMAN, RADBOUD UNIVERSITY, THE NETHERLANDS., KAUANE BORDIN, UFRGS, ELIZABETH H. BOUGHTON, ARCHBOLD BIOLOGICAL STATION'S BUCK ISLAND RANCH, USA., VANESSA BOUKILI, UNIVERSITY OF CONNECTICUT, USA, DAVID M. J. S. BOWMAN, UNIVERSITY OF TASMANIA, AUSTRALIA., SANDRA BRAVO, UNIVERSIDAD NACIONAL DE SANTIAGO DEL ESTERO, MARCO RICHARD BRENDEL, UNIVERSITY OF HOHENHEIM, MARTIN R. BROADLEY, UNIVERSITY OF NOTTINGHAM, UK, KERRY A. BROWN, KINGSTON UNIVERSITY, UK., HELGE BRUELHEIDE, MARTIN LUTHER UNIVERSITY HALLE?WITTENBERG, GERMANY, FERNANDO CASANOVES, CATIE-CENTRO AGRONÓMICO TROPICAL DE INVESTIGACIÓN Y ENSEÑANZA, COSTA RICA, F. STUART CHAPIN, UNIVERSITY OF ALASKA FAIRBANKS, USA, STEFANO CHELLI, UNIVERSITY OF CAMERINO, ITALY, SI?CHONG CHEN, ROYAL BOTANIC GARDENS, UK, ANPING CHEN, COLORADO STATE UNIVERSITY, USA, PAOLO CHERUBINI, UNIVERSITY OF BRITISH COLUMBIA, CANADA, FRANCESCO CHIANUCCI, CREA – RESEARCH CENTRE FOR FORESTRY AND WOOD, ITALY, BRENDAN CHOAT, WESTERN SYDNEY UNIVERSITY, AUSTRALIA, GUILHERME G. MAZZOCHINI, UNIVERSITY OF CAMPINAS, CAMPINAS, BRAZIL, SOPHIE GACHET, UNIV AVIGNON, FRANCE, RACHAEL GALLAGHER, MACQUARIE UNIVERSITY, AUSTRALIA, GISLENE GANADE, UFRN, BRAZIL., MARY-CLAIRE GLASENHARDT, THE MORTON ARBORETUM, USA, ALAIN HAMBUCKERS, UNIVERSITY OF LIÈGE, BELGIUM, MASAE ISHIHARA, KYOTO UNIVERSITY, JAPAN, LEONID IVANOV, TYUMEN STATE UNIVERSITY, RUSSIA, LARISSA IVANOVA, TYUMEN STATE UNIVERSITY, RUSSIA., COLLEEN M. IVERSEN, OAK RIDGE NATIONAL LABORATORY, USA, JORDI IZQUIERDO, Universitat Politècnica de Catalunya, Spain, ROBERT B. JACKSON, STANFORD UNIVERSITY, USA, FRANCESCA GANGA, UNIVERSITY OF CAGLIARI, ITALY, PABLO GARCÍA-PALACIOS, UNIVERSIDAD REY JUAN CARLOS, SPAIN, VERÓNICA GARGAGLIONE, UNIVERSIDAD NACIONAL DE LA PATAGONIA AUSTRAL, ARGENTINA, ERIC GARNIER, UNIV. MONTPELLIER, FRANCE, JOSE LUIS GARRIDO, ESTACIÓN EXPERIMENTAL DEL ZAIDÍN, SPAIN, ANDRÉ LUÍS DE GASPER, UNIVERSIDADE REGIONAL DE BLUMENAU, BRAZIL, GUILLERMO GEAIZQUIERDO, INIA?CIFOR, SPAIN, DAVID GIBSON, SOUTHERN ILLINOIS UNIVERSITY CARBONDALE, USA, ANDREW N. GILLISON, CENTER FOR BIODIVERSITY MANAGEMENT, AUSTRALIA, AELTON GIROLDO, INSTITUTO FEDERAL DE EDUCAÇÃO CIÊNCIA E TECNOLOGIA DO CEARÁ, BRAZIL, SEAN GLEASON, WATER MANAGEMENT AND SYSTEMS RESEARCH UNIT, USA, MARIANA GLIESCH, INSTITUTE OF INTEGRATIVE BIOLOGY, SWITZERLAND, EMMA GOLDBERG, UNIVERSITY OF MINNESOTA, USA, BASTIAN GÖLDEL, AARHUS UNIVERSITY, DENMARK, ERIKA GONZALEZ-AKRE, NORWEGIAN UNIVERSITY OF SCIENCE AND TECHNOLOGY NTNU, NORWAY, JOSE L. GONZALEZ-ANDUJAR, CSIC-INSTITUTE FOR SUSTAINABLE AGRICULTURE (IAS), SPAIN, ANDRÉS GONZÁLEZ-MELO, UNIVERSIDAD DEL ROSARIO, COLOMBIA, ANA GONZÁLEZ-ROBLES, UNIVERSIDAD DE JAÉN, SPAIN, BENTE JESSEN GRAAE, NORWEGIAN UNIVERSITY OF SCIENCE AND TECHNOLOGY NTNU, NORWAY, ELENA GRANDA, UNIVERSITY OF ALCALÁ, SPAIN, SARAH GRAVES, UNIVERSITY OF FLORIDA, USA, WALTON A. GREEN, HARVARD UNIVERSITY, USA, THOMAS GREGOR, SENCKENBERG RESEARCH INSTITUTE AND NATURAL HISTORY MUSEUM, GERMANY, NICOLAS GROSS, UNIVERSIDAD REY JUAN CARLOS, SPAIN, GREG R. GUERIN, THE UNIVERSITY OF ADELAIDE, AUSTRALIA, ANGELA GÜNTHER, MAX PLANCK INSTITUTE FOR BIOGEOCHEMISTRY, GERMANY, ALVARO G. GUTIÉRREZ, UNIVERSIDAD DE CHILE, CHILE, LILLIE HADDOCK, COLLEGE PARK, USA, ANNA HAINES, THE UNIVERSITY OF MANCHESTER, UK, JEFFERSON HALL, SMITHSONIAN TROPICAL RESEARCH INSTITUTE, REPUBLIC OF PANAMA, WENXUAN HAN, CHINA AGRICULTURAL UNIVERSITY, CHINA, SANDY P. HARRISON, UNIVERSITY OF READING, UK, WESLEY HATTINGH, UNIVERSITY OF THE WITWATERSRAND, SOUTH AFRICA, JOSEPH E. HAWES, ANGLIA RUSKIN UNIVERSITY, UK, TIANHUA HE, CURTIN UNIVERSITY, AUSTRALIA, PENGCHENG HE, CHINESE ACADEMY OF SCIENCES, CHINA, JACOB MASON HEBERLING, CARNEGIE MUSEUM OF NATURAL HISTORY, USA, AVELIINA HELM, UNIVERSITY OF TARTU, ESTONIA, STEFAN HEMPEL, FREIE UNIVERSITÄT BERLIN, GERMANY, JÖRN HENTSCHEL, FRIEDRICH-SCHILLER-UNIVERSITÄT JENA, GERMANY, BRUNO HÉRAULT, UNIVERSITÉ DE MONTPELLIER, FRANCE, ANA-MARIA HERE, TRANSILVANIA UNIVERSITY OF BRASOV, ROMANIA, KATHARINA HERZ, MARTIN LUTHER UNIVERSITY HALLE?WITTENBERG, GERMANY, MYRIAM HEUERTZ, UNIV. BORDEAUX, FRANCE, THOMAS HICKLER, GOETHE UNIVERSITY, GERMANY, PETER HIETZ, UNIVERSITY OF NATURAL RESOURCES AND LIFE SCIENCES, AUSTRIA, PEDRO HIGUCHI, SANTA CATARINA STATE UNIVERSITY, BRAZIL, ANDREW L. HIPP, THE MORTON ARBORETUM, USA, ANDREW HIRONS, UNIVERSITY CENTRE MYERSCOUGH, UK, MARIA HOCK, INSTITUTE FOR ECOSYSTEM RESEARCH/GEOBOTANY, GERMANY, JAMES AARON HOGAN, FLORIDA INTERNATIONAL UNIVERSITY, USA, KAREN HOLL, UNIVERSITY OF CALIFORNIA, USA, OLIVIER HONNAY, PLANT CONSERVATION AND POPULATION BIOLOGY, BELGIUM, KNUT ANDERS HOVSTAD, DEPARTMENT OF LANDSCAPE AND BIODIVERSITY, NORWAY, TOMOAKI ICHIE, KOCHI UNIVERSITY, JAPAN, BORIS IGIC, UNIVERSITY OF ILLINOIS AT CHICAGO, USA, ESTELA ILLA, UNIVERSITAT DE BARCELONA, SPAIN, MARNEY ISAAC, UNIVERSITY OF TORONTO, CANADA, BENJAMIN JACKSON, UNIVERSITY OF EDINBURGH, SCOTLAND, HERVÉ JACTEL, UNIV. BORDEAUX, FRANCE, ANDRZEJ M. JAGODZINSKI, UNIVERSITY OF LIFE SCIENCES, POLAND, UTE JANDT, MARTIN LUTHER UNIVERSITY HALLE-WITTENBERG, GERMANY, STEVEN JANSEN, ULM UNIVERSITY, GERMANY, THOMAS, University of Oxford [Oxford], University of Helsinki, Tarbiat Modaras University, Roma Tre University, Institut National de la Recherche Agronomique (INRA)-Université de Lorraine (UL)-Institut National de la Recherche Agronomique (INRA)-Université de Lorraine (UL), Centre for Biodiversity and Sustainable Land-use, University of Göttingen, Göttingen, Germany, Department of Biology, University of North Florida, Jacksonville, FL, USA, University of Copenhagen = Københavns Universitet (KU)-University of Copenhagen = Københavns Universitet (KU), Department of Range Management, Faculty of Natural Resources and Marine Sciences, Tarbiat Modares University, Noor, Iran, University of Innsbruck, School of Geography, University of Leeds, Leeds, UK, Centre for Ecology and Conservation, College of Life and Environmental Sciences, University of Exeter, Penryn, UK., School of Biological Sciences, The University of Adelaide, Adelaide, SA, Australia, Centre de Coopération Internationale en Recherche Agronomique pour le Développement (Cirad)-Centre international d'études supérieures en sciences agronomiques (Montpellier SupAgro)-Institut national d’études supérieures agronomiques de Montpellier (Montpellier SupAgro), Institut national d'enseignement supérieur pour l'agriculture, l'alimentation et l'environnement (Institut Agro)-Institut national d'enseignement supérieur pour l'agriculture, l'alimentation et l'environnement (Institut Agro)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), University of California at Berkeley, Berkeley, CA, USA, Department of Green Chemistry and Technology, Ghent University, Gent, Belgium, Department of Environment, Ghent University, Gent, Belgium, Department of Life and Environmental Sciences, Botany Division, University of Cagliari, Cagliari, Italy, Museo Nacional de Ciencias Naturales-CSIC, Madrid, Spain, Environmental Change Institute, University of Oxford, Oxford, UK, Institut für Biologie, Freie Universität Berlin, Berlin, Germany, Department of Biological and Environmental Sciences, University of Gothenburg, Gothenburg, Sweden, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil, Universiteit Gent = Ghent University [Belgium] (UGENT), School of Geography, Geology and Environment, University of Leicester, Leicester, UK, Institute of Landscape and Plant Ecology, University of Hohenheim, Stuttgart, Germany, Institute of Biology/Geobotany and Botanical Garden, Martin Luther University Halle-Wittenberg, Halle, Germany, German Center for Integrative Biodiversity Research (iDiv) Halle-Jena- Leipzig, Leipzig, Germany, University of Toronto [Scarborough, Canada], Faculty of Agricultural and Environmental Sciences, University of Rostock, Rostock, Germany, Università degli Studi di Roma 'La Sapienza' = Sapienza University [Rome], Dipartimento di Bioscienze, Università degli Studi di Milano, Milano, Italy, Department of Plant Biology and Ecology, University of the Basque Country UPV/ EHU, Bilbao, Spain, Department of Chemistry, Life Sciences and Environmental Sustainability, University of Parma, Parma, Italy, Department of Biotechnology and Life Sciences, University of Insubria, Varese, Italy, BIGEA, Department of Biological, Geological and Environmental Sciences, Alma Mater Studiorum – University of Bologna, Bologna, Italy, Escuela de Biología, Universidad de Costa Rica, San José, Costa Rica, The University of Arizona, Tucson, AZ, USA, University of Alaska [Anchorage], Royal Botanic Gardens, Kew, Department of Biology, University of Pisa, Pisa, Italy, Department of Plant Sciences, University of Cambridge, Cambridge, UK, Biotechnical Faculty, University of Ljubljana, Ljubljana, Slovenia, Institut National de la Recherche Agronomique (INRA)-Université de Lorraine (UL)-AgroParisTech, Department of Plant and Soil Sciences, University of Pretoria, Pretoria, South Africa, Department of Landscape Architecture and Rural Systems Engineering, Seoul National University, Seoul, Republic of Korea, Department of Botany and Biodiversity Research, University of Vienna, Department of Environmental and Life Sciences – Biology, Karlstad University, Quantitative Plant Ecology and Biodiversity Research Laboratory, Department of Biology, Faculty of Science, Ferdowsi University of Mashhad, Justus Liebig University, Justus-Liebig-Universität Gießen (JLU), University of Sassari, Consiglio per la Ricerca in Agricoltura e l’analisi dell’economia agraria (CREA), Universidade de São Paulo (USP), Harvard University [Cambridge], Federal University of Rio Grande do Sul, Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Centre National de la Recherche Scientifique (CNRS)-Observatoire Midi-Pyrénées (OMP), Météo France-Centre National d'Études Spatiales [Toulouse] (CNES)-Université Fédérale Toulouse Midi-Pyrénées-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD)-Météo France-Centre National d'Études Spatiales [Toulouse] (CNES)-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD), Université Paul-Valéry - Montpellier 3 (UPVM)-Centre international d'études supérieures en sciences agronomiques (Montpellier SupAgro)-École pratique des hautes études (EPHE), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD [France-Sud])-Institut national d’études supérieures agronomiques de Montpellier (Montpellier SupAgro), University of Campinas [Campinas] (UNICAMP), University of Cagliari, Universidad de Chile, University of Natural Resources and Life Sciences (BOKU), University of California, Norwegian Institute of Bioeconomy Research (NIBIO), Kyoto University [Kyoto], Centre National de la Recherche Scientifique (CNRS)-Observatoire des Sciences de l'Univers de Rennes (OSUR)-Institut Ecologie et Environnement (INEE), Centre National de la Recherche Scientifique (CNRS)-Centre National de la Recherche Scientifique (CNRS)-Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES), University of Copenhagen = Københavns Universitet (KU), University of Venda, Philipps University of Marburg, Institut National de la Recherche Agronomique (INRA)-École nationale supérieure agronomique de Toulouse [ENSAT]-Institut National Polytechnique (Toulouse) (Toulouse INP), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées, State University of New York, Stonybrook, IT University of Copenhagen, Smithsonian Environmental Research Center, Humboldt University of Berlin, Georg-August-University [Göttingen], Centre de Coopération Internationale en Recherche Agronomique pour le Développement (Cirad)-Institut de Recherche pour le Développement (IRD)-Centre international d'études supérieures en sciences agronomiques (Montpellier SupAgro)-Institut national d’études supérieures agronomiques de Montpellier (Montpellier SupAgro), Nelson Mandela Metropolitan University [Port Elizabeth, South Africa], Netherlands Centre for Biodiversity Naturalis, University of Leipzig [Leipzig, Allemagne], Unité d'Agronomie, University of Debrecen-Research Centre for Molecular Medicine-Medical and Health Science Centre, Global Change Research Institute, University of California [Berkeley], Natural resources institute Finland, Universita degli Studi di Cagliari [Cagliari], Tel Aviv University [Tel Aviv], Oklahoma State University [Stillwater], Kyoto University [Kyoto]-Kyoto University [Kyoto], Universidade Estadual de Campinas (UNICAMP), Universidad Nacional Autónoma de México (UNAM), Vrije universiteit = Free university of Amsterdam [Amsterdam] (VU), Universidad Autonoma de Madrid (UAM), University of Parma = Università degli studi di Parma [Parme, Italie], University of Milan, Forschungszentrum Juelich, Université Nice Sophia Antipolis (... - 2019) (UNS), U.S. Department of Energy [Washington] (DOE)-UT-Battelle, LLC-Stony Brook University [SUNY] (SBU), State University of New York (SUNY)-State University of New York (SUNY), University of Extremadura, University of Göttingen - Georg-August-Universität Göttingen, Universidade de Lisboa (ULISBOA), Federal University of Lavras, Universita degli Studi di Padova, Leiden University, University of California [Riverside] (UCR), Ferdowsi University of Mashhad, Museo Nacional de Ciencias Naturales (MNCN), Departments of Botany and Zoology, Federal University of Para - Universidade Federal do Para [Belem - Brésil], Institut National de la Recherche Agronomique (INRA)-Université d'Orléans (UO), Institut national polytechnique Félix Houphouët-Boigny, Universität Leipzig [Leipzig], Institut National de la Recherche Agronomique (INRA)-Université Clermont Auvergne (UCA), Institut national d’études supérieures agronomiques de Montpellier (Montpellier SupAgro), Institut national d'enseignement supérieur pour l'agriculture, l'alimentation et l'environnement (Institut Agro)-Institut national d'enseignement supérieur pour l'agriculture, l'alimentation et l'environnement (Institut Agro)-Centre international d'études supérieures en sciences agronomiques (Montpellier SupAgro)-Centre de Coopération Internationale en Recherche Agronomique pour le Développement (Cirad)-Institut de Recherche pour le Développement (IRD)-Institut National de la Recherche Agronomique (INRA), Consejo Nacional de Investigaciones Científicas y Técnicas, Instituto Multidisciplinario de Biología Vegetal (IMBIV), and Factulad de Ciencias Exactas, Físicas y Naturales, Universidad Nacional de Córdoba, Córdoba, Argentina, Laboratoire d'Ecologie Alpine (LECA), Centre National de la Recherche Scientifique (CNRS)-Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry])-Université Joseph Fourier - Grenoble 1 (UJF)-Université Grenoble Alpes (UGA), Imperial College London, London SW7 2AZ, UK., Department of Zoology, University of Oxford, Oxford, UK, Balliol College, University of Oxford, Oxford, UK, University of Roma Tre, Rome, Italy, Biodiversity Conservation Laboratory, Department of Environment, University of the Aegean, Mytilene, Greece, Institute of Ecology and Evolution, University of Bern, Bern, Switzerland, Tartu Observatory, University of Tartu, Tartumaa, Estonia, Graduate School of Life Sciences, Tohoku University, Sendai, Japan, Centre National de la Recherche Scientifique (CNRS)-Institut de recherche pour le développement [IRD] : UMR237-Aix Marseille Université (AMU)-Avignon Université (AU), Universidad de Jaén, Jaén, Spain, UMR Nancy-Université- INRA Agronomie et Environnement Nancy-Colmar, Nancy Université, Conicet-Consejo Nacional de Investigaciones Científicas y Técnicas, Buenos Aires, Argentina, Environmental Sciences, Guelph, University of Massachusetts Amherst, Amherst, MA, USA, Wageningen University and Research Center (WUR), University of Victoria, Victoria, BC, Canada, Department of Ecology, University of Innsbruck, Innsbruck, Austria, Department of Biological Sciences-Lancaster University, Centre de Coopération Internationale en Recherche Agronomique pour le Développement (Cirad)-Centre international d'études supérieures en sciences agronomiques (Montpellier SupAgro)-Institut national d’études supérieures agronomiques de Montpellier (Montpellier SupAgro)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Helmholtz Centre for Environmental Research (UFZ), School of Informatics, Computing, and Cyber Systems, Northern Arizona University, Flagstaff, AZ, USA, Université Clermont Auvergne (UCA)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Universiteit Gent [Ghent], School of Forest Resources and Conservation, University of Florida, Gainesville, FL, USA, University of Tasmania, Hobart, Tas., Australia, AMAP, IRD, Herbier de Nouvelle-Calédonie, Nouméa, New Caledonia, Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS)-Centre de Coopération Internationale en Recherche Agronomique pour le Développement (Cirad)-Institut de Recherche pour le Développement (IRD [France-Sud])-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Friedrich-Schiller-Universität Jena, Jena, Germany, Università degli Studi di Roma 'La Sapienza' [Rome], wiss Federal Institute for Forest, Snow and Landscape Research WSL, Birmensdorf, Switzerland, Consejo Superior de Investigaciones Científicas [Spain] (CSIC), Tropical Agricultural Centre for Research and Higher Education (CATIE), Tropical Agricultural Centre for Research and Higher Education, Univ. Bordeaux, INRAE, BIOGECO, Cestas, France, Department of Ecology, Evolution, and Behavior, University of Minnesota, St. Paul, MN, USA, Royal Botanic Gardens, Kew, West Sussex, UK, Department of Biology, Colorado State University, Fort Collins, CO, USA, Hawkesbury Institute for the Environment, Western Sydney University, Sydney, NSW, Australia, Department of Botany and Zoology, Masaryk University, Brno, Czech Republic, Faculty of Environmental Sciences, University of Life Sciences Prague, Praha-Suchdol, Czech Republic, Institute of Botany, Czech Academy of Sciences, Třeboň, Czech Republic, Department of Wildlife, Fish and Environmental Studies, Swedish University of Agricultural Sciences, Umeå, Sweden, MTA Centre for Ecological Research, Tihany, Hungary, Swedish Species Information Centre, Swedish University of Agricultural Sciences, Uppsala, Sweden, Université des Antilles (UA)-Centre National de la Recherche Scientifique (CNRS)-Université de Guyane (UG)-AgroParisTech-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Centre de Coopération Internationale en Recherche Agronomique pour le Développement (Cirad), University of Florida [Gainesville], UFZ - Helmholtz Centre for Environmental Research, School of Geography, Earth and Environmental Sciences – University of Birmingham, Universitat Autònoma de Barcelona [Barcelona] (UAB), University of Ordu, Council for Agricultural Research and Economics (CREA), Université de Sherbrooke [Sherbrooke], Université Paul-Valéry - Montpellier 3 (UM3)-Institut National de la Recherche Agronomique (INRA)-Centre international d'études supérieures en sciences agronomiques (Montpellier SupAgro)-École pratique des hautes études (EPHE)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD [France-Sud])-Institut national d’études supérieures agronomiques de Montpellier (Montpellier SupAgro), United States Department of Agriculture - USDA (USA), Smithsonian Institution, Carnegie Museum of Natural History, Friedrich-Schiller-Universität Jena, Biodiversité, Gènes et Communautés, Goethe-Universität Frankfurt am Main-Senckenberg Gesellschaft für Naturforschung, University of Natural Resources and Applied Life Sciences (BOKU), Florida International University (FIU), Université Catholique de Louvain (UCL), Stanford University [Stanford], Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-Institut Ecologie et Environnement (INEE), Centre National de la Recherche Scientifique (CNRS)-Centre National de la Recherche Scientifique (CNRS)-Observatoire des Sciences de l'Univers de Rennes (OSUR)-Centre National de la Recherche Scientifique (CNRS), University of Tasmania (UTAS), Institut National de la Recherche Agronomique (INRA)-Ecole Nationale Supérieure Agronomique de Toulouse-Institut National Polytechnique (Toulouse) (Toulouse INP), Charles University [Prague], Ghent University [Belgium] (UGENT), Helmholtz Zentrum für Umweltforschung (UFZ), Hokkaido University, Technical University of Munich (TUM), Wageningen University and Research Centre [Wageningen] (WUR), Georg-August-Universität Göttingen, Western Sydney University (UWS), Centre de Coopération Internationale en Recherche Agronomique pour le Développement (Cirad)-Institut de Recherche pour le Développement (IRD)-Centre international d'études supérieures en sciences agronomiques (Montpellier SupAgro)-Institut national d’études supérieures agronomiques de Montpellier (Montpellier SupAgro)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Département de Biologie, Université de Sherbrooke, Sherbrooke, QC, Canada, Université de Sherbrooke, Masaryk University, Czech Academy of Sciences [Prague] (ASCR), Natural Resources Institute Finland, Landcare Research [Lincoln], Université de Montréal [Montréal], Université Libre de Bruxelles [Bruxelles] (ULB), Centre National de la Recherche Scientifique (CNRS)-Ministère de l'Europe et des Affaires étrangères (MEAE), French Institute of Pondicherry (IFP), Normal Zhejiang University, Estonian University of Life Sciences, Institute of Biology Bucharest, Romanian Academy, VU University Amsterdam, Astronomical Institute of the Czech Academy of Sciences, Technische Universität München [München] (TUM), University of Parma, Cardiff School of Social Sciences, University of Cardiff, University of Minnesota [Twin Cities], Manaaki Whenua Landcare Research, Université Côte d'Azur (UCA)-Université Côte d'Azur (UCA)-Institut National de la Santé et de la Recherche Médicale (INSERM), Brookhaven National Laboratory [Upton] (BNL), Stony Brook University [SUNY] (SBU), University of Zürich [Zürich] (UZH), Algoma University [Canada], University of Goettingen, University of Wuerzburg, University of Würzburg, AFSSA, Sherbrooke University, University of Lisbon, Department of Biology (University of Florida), Florida Museum of Natural History, Technical University in Zvolen, University of Zvolen, Fac Forestry & Wood Sci, Université du Québec à Montréal (UQAM), Bioversity International, Consultative Group on International Agricultural Research [CGIAR], Université Clermont Auvergne (UCA), Vrije Universiteit [Brussels] (VUB), University of Tsukuba, Kattge, Jen, Bönisch, Gerhard, Díaz, Sandra, Lavorel, Sandra, Prentice, Iain Colin, Leadley, Paul, Tautenhahn, Susanne, Werner, Gijsbert D A, Aakala, Tuoma, Abedi, Mehdi, Acosta, Alicia Teresa Rosario, Adamidis, George C, Adamson, Kairi, Aiba, Masahiro, Albert, Cécile H, Alcántara, Julio M, Alcázar C, Carolina, Aleixo, Izabela, Ali, Hamada, Amiaud, Bernard, Ammer, Christian, Amoroso, Mariano M, Anand, Madhur, Anderson, Carolyn, Anten, Niel, Antos, Joseph, Apgaua, Deborah Mattos Guimarãe, Ashman, Tia-Lynn, Asmara, Degi Harja, Asner, Gregory P, Aspinwall, Michael, Atkin, Owen, Aubin, Isabelle, Baastrup-Spohr, Lar, Bahalkeh, Khadijeh, Bahn, Michael, Baker, Timothy, Baker, William J, Bakker, Jan P, Baldocchi, Denni, Baltzer, Jennifer, Banerjee, Arindam, Baranger, Anne, Barlow, Jo, Barneche, Diego R, Baruch, Zdravko, Bastianelli, Deni, Battles, John, Bauerle, William, Bauters, Marijn, Bazzato, Erika, Beckmann, Michael, Beeckman, Han, Beierkuhnlein, Carl, Bekker, Renee, Belfry, Gavin, Belluau, Michael, Beloiu, Mirela, Benavides, Raquel, Benomar, Lahcen, Berdugo-Lattke, Mary Lee, Berenguer, Erika, Bergamin, Rodrigo, Bergmann, Joana, Bergmann Carlucci, Marco, Berner, Logan, Bernhardt-Römermann, Marku, Bigler, Christof, Bjorkman, Anne D, Blackman, Chri, Blanco, Carolina, Blonder, Benjamin, Blumenthal, Dana, Bocanegra-González, Kelly T, Boeckx, Pascal, Bohlman, Stephanie, Böhning-Gaese, Katrin, Boisvert-Marsh, Laura, Bond, William, Bond-Lamberty, Ben, Boom, Arnoud, Boonman, Coline C F, Bordin, Kauane, Boughton, Elizabeth H, Boukili, Vanessa, Bowman, David M J S, Bravo, Sandra, Brendel, Marco Richard, Broadley, Martin R, Brown, Kerry A, Bruelheide, Helge, Brumnich, Federico, Bruun, Hans Henrik, Bruy, David, Buchanan, Serra W, Bucher, Solveig Franziska, Buchmann, Nina, Buitenwerf, Robert, Bunker, Daniel E, Bürger, Jana, Burrascano, Sabina, Burslem, David F R P, Butterfield, Bradley J, Byun, Chaeho, Marques, Marcia, Scalon, Marina C, Caccianiga, Marco, Cadotte, Marc, Cailleret, Maxime, Camac, Jame, Camarero, Jesús Julio, Campany, Courtney, Campetella, Giandiego, Campos, Juan Antonio, Cano-Arboleda, Laura, Canullo, Roberto, Carbognani, Michele, Carvalho, Fabio, Casanoves, Fernando, Castagneyrol, Bastien, Catford, Jane A, Cavender-Bares, Jeannine, Cerabolini, Bruno E L, Cervellini, Marco, Chacón-Madrigal, Eduardo, Chapin, Kenneth, Chapin, F Stuart, Chelli, Stefano, Chen, Si-Chong, Chen, Anping, Cherubini, Paolo, Chianucci, Francesco, Choat, Brendan, Chung, Kyong-Sook, Chytrý, Milan, Ciccarelli, Daniela, Coll, Lluí, Collins, Courtney G, Conti, Luisa, Coomes, David, Cornelissen, Johannes H C, Cornwell, William K, Corona, Piermaria, Coyea, Marie, Craine, Joseph, Craven, Dylan, Cromsigt, Joris P G M, Csecserits, Anikó, Cufar, Katarina, Cuntz, Matthia, da Silva, Ana Carolina, Dahlin, Kyla M, Dainese, Matteo, Dalke, Igor, Dalle Fratte, Michele, Dang-Le, Anh Tuan, Danihelka, Jirí, Dannoura, Masako, Dawson, Samantha, de Beer, Arend Jacobu, De Frutos, Angel, De Long, Jonathan R, Dechant, Benjamin, Delagrange, Sylvain, Delpierre, Nicola, Derroire, Géraldine, Dias, Arildo S, Diaz-Toribio, Milton Hugo, Dimitrakopoulos, Panayiotis G, Dobrowolski, Mark, Doktor, Daniel, Dřevojan, Pavel, Dong, Ning, Dransfield, John, Dressler, Stefan, Duarte, Leandro, Ducouret, Emilie, Dullinger, Stefan, Durka, Walter, Duursma, Remko, Dymova, Olga, E-Vojtkó, Anna, Eckstein, Rolf Lutz, Ejtehadi, Hamid, Elser, Jame, Emilio, Thaise, Engemann, Kristine, Erfanian, Mohammad Bagher, Erfmeier, Alexandra, Esquivel-Muelbert, Adriane, Esser, Gerd, Estiarte, Marc, Domingues, Tomas F, Fagan, William F, Fagúndez, Jaime, Falster, Daniel S, Fan, Ying, Fang, Jingyun, Farris, Emmanuele, Fazlioglu, Fatih, Feng, Yanhao, Fernandez-Mendez, Fernando, Ferrara, Carlotta, Ferreira, Joice, Fidelis, Alessandra, Finegan, Bryan, Firn, Jennifer, Flowers, Timothy J, Flynn, Dan F B, Fontana, Veronika, Forey, Estelle, Forgiarini, Cristiane, François, Loui, Frangipani, Marcelo, Frank, Dorothea, Frenette-Dussault, Cedric, Freschet, Grégoire T, Fry, Ellen L, Fyllas, Nikolaos M, Mazzochini, Guilherme G, Gachet, Sophie, Gallagher, Rachael, Ganade, Gislene, Ganga, Francesca, García-Palacios, Pablo, Gargaglione, Verónica, Garnier, Eric, Garrido, Jose Lui, de Gasper, André Luí, Gea-Izquierdo, Guillermo, Gibson, David, Gillison, Andrew N, Giroldo, Aelton, Glasenhardt, Mary-Claire, Gleason, Sean, Gliesch, Mariana, Goldberg, Emma, Göldel, Bastian, Gonzalez-Akre, Erika, Gonzalez-Andujar, Jose L, González-Melo, André, González-Robles, Ana, Graae, Bente Jessen, Granda, Elena, Graves, Sarah, Green, Walton A, Gregor, Thoma, Gross, Nicola, Guerin, Greg R, Günther, Angela, Gutiérrez, Alvaro G, Haddock, Lillie, Haines, Anna, Hall, Jefferson, Hambuckers, Alain, Han, Wenxuan, Harrison, Sandy P, Hattingh, Wesley, Hawes, Joseph E, He, Tianhua, He, Pengcheng, Heberling, Jacob Mason, Helm, Aveliina, Hempel, Stefan, Hentschel, Jörn, Hérault, Bruno, Hereş, Ana-Maria, Herz, Katharina, Heuertz, Myriam, Hickler, Thoma, Hietz, Peter, Higuchi, Pedro, Hipp, Andrew L, Hirons, Andrew, Hock, Maria, Hogan, James Aaron, Holl, Karen, Honnay, Olivier, Hornstein, Daniel, Hou, Enqing, Hough-Snee, Nate, Hovstad, Knut Ander, Ichie, Tomoaki, Igić, Bori, Illa, Estela, Isaac, Marney, Ishihara, Masae, Ivanov, Leonid, Ivanova, Larissa, Iversen, Colleen M, Izquierdo, Jordi, Jackson, Robert B, Jackson, Benjamin, Jactel, Hervé, Jagodzinski, Andrzej M, Jandt, Ute, Jansen, Steven, Jenkins, Thoma, Jentsch, Anke, Jespersen, Jens Rasmus Plantener, Jiang, Guo-Feng, Johansen, Jesper Liengaard, Johnson, David, Jokela, Eric J, Joly, Carlos Alfredo, Jordan, Gregory J, Joseph, Grant Stuart, Junaedi, Decky, Junker, Robert R, Justes, Eric, Kabzems, Richard, Kane, Jeffrey, Kaplan, Zdenek, Kattenborn, Teja, Kavelenova, Lyudmila, Kearsley, Elizabeth, Kempel, Anne, Kenzo, Tanaka, Kerkhoff, Andrew, Khalil, Mohammed I, Kinlock, Nicole L, Kissling, Wilm Daniel, Kitajima, Kaoru, Kitzberger, Thoma, Kjøller, Rasmu, Klein, Tamir, Kleyer, Michael, Klimešová, Jitka, Klipel, Joice, Kloeppel, Brian, Klotz, Stefan, Knops, Johannes M H, Kohyama, Takashi, Koike, Fumito, Kollmann, Johanne, Komac, Benjamin, Komatsu, Kimberly, König, Christian, Kraft, Nathan J B, Kramer, Koen, Kreft, Holger, Kühn, Ingolf, Kumarathunge, Dushan, Kuppler, Jona, Kurokawa, Hiroko, Kurosawa, Yoko, Kuyah, Shem, Laclau, Jean-Paul, Lafleur, Benoit, Lallai, Erik, Lamb, Eric, Lamprecht, Andrea, Larkin, Daniel J, Laughlin, Daniel, Le Bagousse-Pinguet, Yoann, le Maire, Guerric, le Roux, Peter C, le Roux, Elizabeth, Lee, Tali, Lens, Frederic, Lewis, Simon L, Lhotsky, Barbara, Li, Yuanzhi, Li, Xine, Lichstein, Jeremy W, Liebergesell, Mario, Lim, Jun Ying, Lin, Yan-Shih, Linares, Juan Carlo, Liu, Chunjiang, Liu, Daijun, Liu, Udayangani, Livingstone, Stuart, Llusià, Joan, Lohbeck, Madelon, López-García, Álvaro, Lopez-Gonzalez, Gabriela, Lososová, Zdeňka, Louault, Frédérique, Lukács, Balázs A, Lukeš, Petr, Luo, Yunjian, Lussu, Michele, Ma, Siyan, Maciel Rabelo Pereira, Camilla, Mack, Michelle, Maire, Vincent, Mäkelä, Annikki, Mäkinen, Harri, Malhado, Ana Claudia Mende, Mallik, Azim, Manning, Peter, Manzoni, Stefano, Marchetti, Zuleica, Marchino, Luca, Marcilio-Silva, Viniciu, Marcon, Eric, Marignani, Michela, Markesteijn, Lar, Martin, Adam, Martínez-Garza, Cristina, Martínez-Vilalta, Jordi, Mašková, Tereza, Mason, Kelly, Mason, Norman, Massad, Tara Joy, Masse, Jacynthe, Mayrose, Itay, Mccarthy, Jame, Mccormack, M Luke, Mcculloh, Katherine, Mcfadden, Ian R, Mcgill, Brian J, Mcpartland, Mara Y, Medeiros, Juliana S, Medlyn, Belinda, Meerts, Pierre, Mehrabi, Zia, Meir, Patrick, Melo, Felipe P L, Mencuccini, Maurizio, Meredieu, Céline, Messier, Julie, Mészáros, Ilona, Metsaranta, Juha, Michaletz, Sean T, Michelaki, Chrysanthi, Migalina, Svetlana, Milla, Ruben, Miller, Jesse E D, Minden, Vanessa, Ming, Ray, Mokany, Karel, Moles, Angela T, Molnár, Attila, Molofsky, Jane, Molz, Martin, Montgomery, Rebecca A, Monty, Arnaud, Moravcová, Lenka, Moreno-Martínez, Alvaro, Moretti, Marco, Mori, Akira S, Mori, Shigeta, Morris, Dave, Morrison, Jane, Mucina, Ladislav, Mueller, Sandra, Muir, Christopher D, Müller, Sandra Cristina, Munoz, Françoi, Myers-Smith, Isla H, Myster, Randall W, Nagano, Masahiro, Naidu, Shawna, Narayanan, Ayyappan, Natesan, Balachandran, Negoita, Luka, Nelson, Andrew S, Neuschulz, Eike Lena, Ni, Jian, Niedrist, Georg, Nieto, Jhon, Niinemets, Ülo, Nolan, Rachael, Nottebrock, Henning, Nouvellon, Yann, Novakovskiy, Alexander, Nystuen, Kristin Odden, O'Grady, Anthony, O'Hara, Kevin, O'Reilly-Nugent, Andrew, Oakley, Simon, Oberhuber, Walter, Ohtsuka, Toshiyuki, Oliveira, Ricardo, Öllerer, Kinga, Olson, Mark E, Onipchenko, Vladimir, Onoda, Yusuke, Onstein, Renske E, Ordonez, Jenny C, Osada, Noriyuki, Ostonen, Ivika, Ottaviani, Gianluigi, Otto, Sarah, Overbeck, Gerhard E, Ozinga, Wim A, Pahl, Anna T, Paine, C E Timothy, Pakeman, Robin J, Papageorgiou, Aristotelis C, Parfionova, Evgeniya, Pärtel, Meeli, Patacca, Marco, Paula, Susana, Paule, Juraj, Pauli, Harald, Pausas, Juli G, Peco, Begoña, Penuelas, Josep, Perea, Antonio, Peri, Pablo Lui, Petisco-Souza, Ana Carolina, Petraglia, Alessandro, Petritan, Any Mary, Phillips, Oliver L, Pierce, Simon, Pillar, Valério D, Pisek, Jan, Pomogaybin, Alexandr, Poorter, Hendrik, Portsmuth, Angelika, Poschlod, Peter, Potvin, Catherine, Pounds, Devon, Powell, A Shafer, Power, Sally A, Prinzing, Andrea, Puglielli, Giacomo, Pyšek, Petr, Raevel, Valerie, Rammig, Anja, Ransijn, Johanne, Ray, Courtenay A, Reich, Peter B, Reichstein, Marku, Reid, Douglas E B, Réjou-Méchain, Maxime, de Dios, Victor Resco, Ribeiro, Sabina, 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S. Geological Survey, Duke University, NSW Department of Primary Industries, SUNY-College of Environmental Science and Forestry, Sorbonne-Université, Laboratório de Ecologia Vegetal (LEVEG), George Washington University, National Taiwan University, Institut National Polytechnique Félix Houphouët-Boigny (INP-HB), University Oldenburg, and Biyoloji

Subjects
[SDE] Environmental Sciences, LIFE-HISTORY, Geography & travel, WOOD DENSITY, plant trait, Biodiversity & Conservation, 05 Environmental Sciences, Growth, 580 Plants (Botany), COMMUNITY COMPOSITION, ROOT TRAITS, Biologiska vetenskaper, Ecological modeling, data coverage, data integration, data representativeness, functional diversity, plant traits, TRY plant trait database, Biodiversity, Ecology, Plants, Access to Information, Ecosystem, data representativene, ddc:910, General Environmental Science, Global and Planetary Change, GLOBAL PATTERNS, food and beverages, LEAF PHOTOSYNTHETIC TRAITS, Biological Sciences, CAVElab, Data processing, ddc:580, [SDE]Environmental Sciences, Biodiversity Conservation, Life Sciences & Biomedicine, INCLINATION ANGLE DISTRIBUTION, Environmental Sciences & Ecology, Ecology and Environment, Database, LITTER DECOMPOSITION, ddc:570, Datenintegration, Environmental Chemistry, DDC 004 / Data processing & computer science, Intraspecific competition, Data integration (Computer science), Science & Technology, Biology and Life Sciences, Plant, 06 Biological Sciences, Environmental factor, Nutrient Network, Biology and Microbiology, FUNCTIONAL TRAITS, DDC 580 / Botanical sciences, Earth and Environmental Sciences, ddc:004, [SDE.BE]Environmental Sciences/Biodiversity and Ecology, Environmental Sciences, RELATIVE GROWTH-RATE
Abstract

Plant traits—the morphological, anatomical, physiological, biochemical and phenological characteristics of plants—determine how plants respond to environmental factors, affect other trophic levels, and influence ecosystem properties and their benefits and detriments to people. Plant trait data thus represent the basis for a vast area of research spanning from evolutionary biology, community and functional ecology, to biodiversity conservation, ecosystem and landscape management, restoration, biogeography and earth system modelling. Since its foundation in 2007, the TRY database of plant traits has grown continuously. It now provides unprecedented data coverage under an open access data policy and is the main plant trait database used by the research community worldwide. Increasingly, the TRY database also supports new frontiers of trait-based plant research, including the identification of data gaps and the subsequent mobilization or measurement of new data. To support this development, in this article we evaluate the extent of the trait data compiled in TRY and analyse emerging patterns of data coverage and representativeness. Best species coverage is achieved for categorical traits—almost complete coverage for ‘plant growth form’. However, most traits relevant for ecology and vegetation modelling are characterized by continuous intraspecific variation and trait–environmental relationships. These traits have to be measured on individual plants in their respective environment. Despite unprecedented data coverage, we observe a humbling lack of completeness and representativeness of these continuous traits in many aspects. We, therefore, conclude that reducing data gaps and biases in the TRY database remains a key challenge and requires a coordinated approach to data mobilization and trait measurements. This can only be achieved in collaboration with other initiatives., publishedVersion

Published
2020

48. Phase I/II, open-label, ongoing study of PRN1008 (rilzabrutinib), an oral bruton tyrosine kinase inhibitor, in patients with heavily pretreated immune thrombocytopenia (ITP).

Author

Kuter D., Efraim M., Mayer J., Trneny M., McDonald V., Bird R., Regenbogen T., Garg M., Kaplan Z., Bandman O., Burns R., Neale A., Thomas D., Cooper N., Kuter D., Efraim M., Mayer J., Trneny M., McDonald V., Bird R., Regenbogen T., Garg M., Kaplan Z., Bandman O., Burns R., Neale A., Thomas D., and Cooper N.

Abstract

Background: Despite significant therapeutic advances in ITP over the past 15 years, a subset of patients is refractory to existing options and durable remission remains elusive. PRN1008 (rilzabrutinib) is an oral, reversible, covalent inhibitor of Bruton tyrosine kinase targeting underlying disease mechanisms of platelet destruction. Initial phase I/II dose-escalation results support the 400 mg BID dose as optimal for clinical activity and safety (Kuter. ASH 2019). Aim(s): Subset efficacy/safety analysis of rilzabrutinib at optimal 400 mg BID dose. Method(s): This ongoing, open-label study examines rilzabrutinib in heavily-pretreated ITP adults with baseline platelet counts < 30,000/muL, including patients on stable doses of concomitant corticosteroids/thrombopoietin-receptor agonists who had inadequate response. Primary endpoint: >=2 consecutive platelet counts >=50,000/muL and increase of >=20,000/muL from baseline without requiring rescue medication. Result(s): As of 13Nov2019, 16 patients initiated rilzabrutinib 400 mg BID (14/16 ongoing). Median baseline age: 44.5 years (range, 21-74); all primary ITP for a median of 7.2 years (range, 0.8-40.3) and median of 6 prior therapies (range, 1-41; 25% prior splenectomy). Median baseline platelet count was 12,050/muL (range, 3500-27,670/ muL). Related treatment-emergent AEs (all grade 1/2) were similar to the overall study population; most frequent were nausea, diarrhea, and abdominal distension. With a median of 12.1 weeks (range, 1.3-28.9) of rilzabrutinib, 6/16 patients (38%) achieved the primary endpoint (Table 1); none required rescue medication. In 10 patients treated >=12 weeks, 5 (50%) achieved the primary endpoint. Platelet counts increased to >=30,000/muL by day 8 for 100% of responders (n=6/16; Figure 1) and this increase is predictive of achieving the primary endpoint and durable response. Conclusion(s): Rilzabrutinib 400 mg BID showed rapid, durable clinical activity, and a positive day 8 predictive value

Published
2020

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