Search

Your search keyword '"Kaplan, Marshall"' showing total 692 results
Start Over Author "Kaplan, Marshall"
692 results on '"Kaplan, Marshall"'

1. Responses

Author

Kaplan, Marshall R.

Published
2011

4. The Community Builders

Author

EICHLER, EDWARD P., KAPLAN, MARSHALL, EICHLER, EDWARD P., and KAPLAN, MARSHALL

Published
2023

10. Identification of HLA-A2–restricted CD8+ Cytotoxic T Cell Responses in Primary Biliary Cirrhosis

Author

Kita, Hiroto, Lian, Zhe-Xiong, Van de Water, Judy, He, Xiao-Song, Matsumura, Shuji, Kaplan, Marshall, Luketic, Velimir, Coppel, Ross L, Ansari, Aftab A, and Gershwin, M Eric

Subjects
Biomedical and Clinical Sciences, Immunology, Clinical Research, Immunization, Autoimmune Disease, Chronic Liver Disease and Cirrhosis, Digestive Diseases, Liver Disease, Aetiology, 2.1 Biological and endogenous factors, Inflammatory and immune system, Antigen Presentation, Antigen-Antibody Complex, Autoimmunity, Cytokines, Dendritic Cells, Dihydrolipoyllysine-Residue Acetyltransferase, Epitopes, HLA-A2 Antigen, Humans, Lymphocyte Activation, Oligopeptides, Pyruvate Dehydrogenase Complex, T-Lymphocytes, Cytotoxic, autoimmunity, cytotoxic T cells, cholangitis, epitopes, cross-priming, Medical and Health Sciences, Biomedical and clinical sciences, Health sciences
Abstract

Primary biliary cirrhosis (PBC) is characterized by an intense biliary inflammatory CD4(+) and CD8(+) T cell response. Very limited information on autoantigen-specific cytotoxic T lymphocyte (CTL) responses is available compared with autoreactive CD4(+) T cell responses. Using peripheral blood mononuclear cells (PBMCs) from PBC, we identified an HLA-A2-restricted CTL epitope of the E2 component of pyruvate dehydrogenase (PDC-E2), the immunodominant mitochondrial autoantigen. This peptide, amino acids 159-167 of PDC-E2, induces specific MHC class I-restricted CD8(+) CTL lines from 10/12 HLA-A2(+) PBC patients, but not controls, after in vitro stimulation with antigen-pulsed dendritic cells (DCs). PDC-E2-specific CTLs could also be generated by pulsing DCs with full-length recombinant PDC-E2 protein. Furthermore, using soluble PDC-E2 complexed with either PDC-E2-specific human monoclonal antibody or affinity-purified autoantibodies against PDC-E2, the generation of PDC-E2-specific CTLs, occurred at 100-fold and 10-fold less concentration, respectively, compared with soluble antigen alone. Collectively, these data demonstrate that autoantibody, helper, and CTL epitopes all contain a shared peptide sequence. The finding that autoantigen-immune complexes can not only cross-present but also that presentation of the autoantigen is of a higher relative efficiency, for the first time defines a unique role for autoantibodies in the pathogenesis of an autoimmune disease.

Published
2002

13. Schools Located Near Highways: Problems and Prospects. Final Report [and] Case Studies.

Author

Kaplan (Marshall), Gans and Kahn, San Francisco, CA., Wells, Leslie J., Shapiro, Richard, and Felsburg, Robert W.

Abstract

In this 1977 publication, findings and recommendations are presented from 22 case studies involving the impact on schools adjacent to highway systems in the states of California, New Mexico, Colorado, Texas, Missouri, Maryland, and Virginia. The impacts described include: noise; vehicular and pedestrian safety; air pollution; access; circulation changes in service area; and visual distraction. The cases illustrate the range of perceived impacts associated with various types of school/highway positionings and the range of mitigation measures utilized to minimize negative impacts and their relative success. Positive impacts on schools include increased vehicular and pedestrian accessibility, and visibility from the road. Negative impacts include noise, safety, air pollution, and visual distraction. No perceived positive impacts are reported on the highway system from the school; negative school-to-highway impacts include traffic congestion, circulation, and decreased vehicular safety. Twenty-six broad recommendations are provided to minimize the adverse impact resulting from school/highway juxtapositioning. An appendix provides background and study objectives along with study methodology. (GR)

Published
1977

14. Urban Policy: An Uneven Past, an Uncertain Future.

Author

Kaplan, Marshall

Abstract

Reviews national efforts to define urban policies and programs from 1960 through 1994, and suggests reasons for the failure of most in meeting the expectations of their advocates or the American people. It identifies principles and policies that should guide future urban policy makers in dealing with the difficult problems facing the modern city. (GR)

Published
1995

27. Primary biliary cirrhosis

Author

Kaplan, Marshall M. and Gershwin, M. Eric

Subjects
Biliary cirrhosis -- Health aspects, Biliary cirrhosis -- Care and treatment
Abstract

The characteristics of primary biliary cirrhosis, which is described as a slow and progressive autoimmune disease, are presented. The autoimmune responses associated with this disorder, and their treatments are discussed in detail.

Published
2005

32. Evaluation of abnormal liver-enzyme results in asymptomatic patients

Author

Pratt, Daniel S. and Kaplan, Marshall M.

Subjects
Liver diseases -- Physiological aspects, Enzymes -- Measurement
Abstract

Whenever a patient has elevated liver enzymes but no symptoms, the doctor should repeat the blood test to make sure it is correct. Elevated blood levels of liver enzymes is usually caused by liver damage. However, a minimal elevation is probably not important if the patient is known not to have liver disease. Elevated liver enzymes can be caused by alcohol, some drugs, chronic hepatitis, autoimmune hepatitis, hemochromatosis, Wilson's disease, hepatic steatosis, and alpha(sub 1)-antitrypsin deficiency. Celiac sprue, muscle disorders, and strenuous exercise can also cause elevated liver enzymes.

Published
2000

49. Primary biliary cirrhosis

Author

Kaplan, Marshall M.

Subjects
Biliary cirrhosis -- Care and treatment, Autoimmune diseases -- Physiological aspects
Abstract

Primary biliary cirrhosis is a liver disease characterized by an autoimmune attack against cell mitochondria. This damages the small bile ducts in the liver. The disorder affects women primarily and is characterized by itching, fatigue, jaundice and an enlarged liver. A liver biopsy can confirm the diagnosis. Itching can be controlled with drugs that bind bile acids and ursodiol, colchicine and methotrexate are used to treat the underlying autoimmune disorder. The most effective treatment is a liver transplant.

Published
1996

Catalog

Books, media, physical & digital resources
See catalog results