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1. Neutralising antibody potency against SARS-CoV-2 wild-type and omicron BA.1 and BA.4/5 variants in patients with inflammatory bowel disease treated with infliximab and vedolizumab after three doses of COVID-19 vaccine (CLARITY IBD): an analysis of a prospective multicentre cohort study

Author

Islam, Madiha, Croft, Nick, Cipriano, Bessie, Francia, Caroline, Khalid, Nosheen, Kingston, Ashley, Lee, Irish, Lehmann, Anouk, Naik, Kinnari, Samuels, Kevin, Plaatjies, Nicolene, Khatun, Hafiza, Bokth, Farjana, Pabriaga, Elise, Saich, Rebecca, Cousins, Hayley, Fraser, Wendy, Thomas, Rachel, Brown, Matthew, White, Benjamin, Kirkineziadis, Nikolaos, Tilley, Bernadette, Porter, Pennie, Bryant, Rachel, Robaczewska, Natalia, Muhammed, Rafeeq, Bi, Rehana, Cotter, Catherine, Grove, Jayne, Hong, Kate, Howman, Ruth, Mitchell, Monica, Clayton, Sophie, Rogers, Louise, Sultan, Sugrah, Rooney, Melanie, Cottrill, Charlotte, Singh, Salil, Dawe, Chris, Hull, Robert, Silva, Natalie, Chadwick, Julie, Robertson, Laura, Manning, Jonathan, Finlayson, Lauren, Roebuck, Allison, Dawson, Joy, Sonwalkar, Sunil, Chambers, Naomi, Robinson, Matthew, Haigh, Andrew, Matapure, Lear, Raine, Tim, George, Varun, Kapizioni, Christina, Strongili, Konstantina, Thompson, Tina, Ahmed, Mohamed, Kontos, Christos, Dawson, Claire, Bourges, Christophe, Barbutti, Isabella, Gozzard, Megan E, Hendy, Philip, Bull, Rhian, Costa, Patricia, Davey, Lisa, Hannington, Hayley, Nundlall, Kribashnie, Martins, Catarina, Avanzi, Laura, Carungcong, Jaime, Barr, Sabrina, Appleby, Richard, Johnson, Emma, Shakweh, Eathar, Phillis, Kath, Gascoyne, Rachel, Crowder, Amanda, Whileman, Amanda, London, Ian, Grounds, Jenny, Martin, Emmeline, Pajak, Susie, Price, Jude, Cawley, Kathryn, Powell, Sandra, Kearsley, Nichola, Dhar, Anjan, Brown, Ellen, Cowton, Amanda, Stamp, Kimberley, Warner, Ben, Stuart, Carmel, Lacey, Louise, de Silva, Shanika, Allcock, Clare, Harvey, Philip, Jones, Lesley, Cooke, Elise, Slater, Jayne, King, Dominic, Brooks, Johanne, Baker, Pearl, Beadle, Hannah, Cruz, Carina, Potter, Debbie, Collum, Joe, Masters, Farzana, Kumar, Aashish, Coetzee, Samantha, Peiu, Mihaela, Icke, Becky, Williams, Jill, Raj, Meena, Gaynor, Edward, Chadokufa, Sibongile, Huggett, Bonita, Meghari, Hamza, El-Khouly, Sara, Kiparissi, Fevronia, Girshab, Waffa, Russell-Walker, Lynda, Jackson, Christopher, Sidler, Sara, Claridge, Andrew, Fowler, Emily, McCafferty, Laura, Haxton, Lesley, Irving, Peter, Christodoulides, Karolina, Clifford, Angela, Dawson, Patrick, Honap, Sailish, Lim, Samuel, Luber, Raphael, Mahiouz, Karina, Meade, Susanna, Raymode, Parizade, Reynolds, Rebecca, Stanton, Anna, Tripoli, Sherill, Hare, Naomi, Odukwe, Sopuluchukwu, Balachandran, Senthuran, North, Emma, North, Jessica, Browne, Bria, Cordle, Jessica, Jameson, Ella, Siaw, Yih Harn, Manzano, Lane, Segal, Jonathan, Al-Bakir, Ibrahim, Khakoo, Imran, Portukhay, Sofiya, Thoua, Nora, Davidson, Katherine, Miah, Jagrul, Canclini, Lisa, Hall, Alex, Furreed, Hassina, Mitchell-Inwang, Christine, Hayes, Melony, Myers, Sally, Talbot, Alison, Turnbull, Jack, Whitehead, Emma, Stamp, Katie, Pattinson, Alison, Mathew, Verghese, Sherris, Leanne, Wilcox, Julie, Ramachandran, Sankaranarayanan, Robertson, Hayley, Harvey, Angela, Hicks, Lucy, Byrne, Tara-Marie, Cabreros, Leilani, Downing-Wood, Hannah, Hunter, Sophie, Saifuddin, Mohammad Aamir, Prabhudev, Hemanth, Balarajah, Sharmili, Krucznski, Jan, Driva, Kalliopi, D'Mello, Andrea, Shah, Parith, Castro-Seoane, Rocio, Ibraheim, Hajir, Constable, Laura E, Lo, Jonathan W, Torkizadeh, Melissa, Hermangild, Sherine K, Sutherland, Helen, Wilhelmsen, Elva, Mackintosh, Katherine, Verma, Ajay M, Sebastian, Juliemol, Peerally, Mohammad Farhad, Guerdette, Anne-marie, Coburn, Susan, Novem lam, Ching Yee, Durrant, Donna, Schaefer, Belinda, Serna, Solange, Shahzad, Muhammad, Kent, Alexandra, Choong, Lee Meng, Pantaloni, Benedetta, Ravdas, Pantelis, Vadamalayan, Babu, Foley, Stephen, Arnold, Becky, Heeley, Cheryl, Lovegrove, Wayne, Sowton, Donna, Allsop, Lynne, Gregory, Heidi, Gill, Mandy, Holmes, Megan, Balan, Valeria, Smith, Susan, Turner, Sarah, Smith, Philip J, Steel, Alan, Bretland, Giovanna, King, Sarah, Lofthouse, Martina, Rigby, Lindsey, Subramanian, Sreedhar, Tyrer, David, Martin, Kate, Probert, Christopher, Kamperidis, Nikolaos, Adedoyin, Temi, Baden, Manisha, Brown, Jeannette, Chacko, Feba, Young, Lisa, Cicchetti, Michela, Saifuddin, Mohammad, Yesupatham, Priya, Gowda, Rohit, Williams, Maureen, Kemp, Karen, Akhand, Rima, Gray, Glaxy, John, Anu, John, Maya, Mohammed, Tasnim, Sathe, Diamond, Jones, Natasha, Soren, Jennifer, Sprakes, Michael, Burton, Julie, Kane, Patricia, Lupton, Stephanie, Bartholomew, Jacqueline, Denis, Elizabeth, Daniels, Alison, MacFaul, George, Scaletta, Diane, Siamia, Loria, Williams, Felicity, Green, Chloe, Ver, Zeljka, Lamb, Chris, Doona, Mary, Hogg, Ashleigh, Jeffrey, Lesley, King, Andrew, Speight, R Alexander, Doyle, Jennifer, Owen, Ruth, Haworth, Jenny, Patterson, Linda, Varnaulasingam, Vithusa, Mowat, Craig, Rice, Debbie, MacFarlane, Susan, MacLeod, Anne, Mohammed, Samera, Murray, Shona, Elliott, Anne, Anne Morris, Mary, Coke, Louise, Hindle, Grace, Kolokouri, Eirini, Wright, Catherine, Lee, Claire, Ward, Nicola, Dann, Adele, Lockett, Melanie, Cranfield, Charlotte, Jennings, Louise, Srivastava, Ankur, Ward, Lana, Jeynes, Nouf, Ranga, Poonam, Rajasekhar, Praveen, Gallagher, Lisa, Ward, Jill, Basnett, Rae, Murphy, Judy, Parking, Lauren, Lawson, Emma, Short, Stacey, Devadason, David, Moran, Gordon, Khan, Neelam, Tarr, Lauren, Olivia, Charmaine, Warbarton, Samantha, Kelly, Sian, Limdi, Jimmy, Goulden, Kay, Javed, Asad, McKenzie, Lauren, Melville, Julie, Liu, Eleanor, Sabine, Joseph, Jacob, Patricia, McSorland, Denise, Schofield, Nick, Cornwall, Lisa, Quirke, James, Crook, Emma, Turner, Anne, Bhandari, Pradeep, Baker-Moffatt, Michelle, Dash, Joanne, Le Poidevin, Alison, Downe, Hayley, Bombeo, Lucille, Blackman, Helen, Smith, Rebecca, Wiles, Alan, Bloxham, Hannah, Dias, Jose, Nadar, Evelyn, Curgenven, Hollie, Gilham, Ellie, Macdonald, Jonathan, Finan, Shona, McMeeken, Faye, Mahmood, Misbah, Shields, Stephanie, Seenan, John Paul, DeSilva, Des, Malkakorpi, Susanna, Carson, Rachel, Lawrence, Holly, Boateng, Ofori, Kpodo, Felix, Whiteoak, Simon, Edger-Earley, Kelli, Vamplew, Luke, Samways, Joanna, Roffe, Sue, Ingram, Sarah, James, Joel, Botfield, Sharon, Hammonds, Fiona, James, Clare, Berry, Zoe, Aspinall, Gemma, Hawkins, Sarah, Parkinson, Marian, Gardner-Thorpe, Helen, Marriott, Suzie, Redstone, Clare, Windak, Halina, Adam, Ana-Marie, Mabb, Hannah, Stevenson, Emma, Record, Jessica, Murray, Charles, Diaba, Cynthia, Joseph, Fexy, Pakou, Glykeria, Gleeson, Yvonne, Nunag, Annalyn, Berrill, James, Stroud, Natalie, Pothecary, Carla, Roche, Lisa, Turner, Keri, Deering, Lisa, Israel, Lynda, Baker, Evelyn, Nash, Maxine, Fagbemi, Andrew, Jennings, Felicia, Mayor, Imelda, Wilson, Jill, Wheeler, Alice, Phillips, Nicola, Gordon, John, Levell, Emma, Zagalo, Silvia, Hoad, Ina, Anil, Bindu, Russell, Richard, Henderson, Paul, Millar, Margaret, Alexakis, Christopher, Michalak, Natalia, Marriott, Cheryl, Stone, Sarah, Pristopan, Veronika, Saunders, John, Burton, Helen, Cambridge, Vanessa, Clark, Tonia, Ekblad, Charlotte, Hierons, Sarah, Katebe, Joyce, Saunsbury, Emma, Perry, Rachel, Brookes, Matthew, Davies, Kathryn, Green, Marie, Plumbe, Ann, Ormerod, Clare, Christensen, Helen, Howlett, Hannah, Keen, Anne, Ogor, Jonathan, Greenhaigh, Marie, Knowles, Karen, Yin, Shanzi, Poulaka, Maria, Anthony, Alpha, Newitt, Emily, Trim, Fiona, Casey, Ruth, Seymour, Katherine, Reed, Catherine, Joy, Lijo, Fogden, Edward, Russell, Kalisha, Hussain, Samia, Phillips, Anne, Abdulla, Muaad, Butterworth, Jeff, Adams, Colene, Carnahan, Mandy, Buckingham, Elizabeth, Childs, Danielle, Magness, Alison, Stickley, Jo, Motherwell, Nichola, Tonks, Louise, Gibson, Hannah, Wistance, Kate, Thomas, Caradog, Brinkworth, Elaine, Connor, Lynda, Cook, Amanda, Rees, Tabitha, Harford, Rachel, Farley, Sean, Jones, Marie, Wesley, Emma, Moss, Alison, Lucas, Jacob, Lorimer, Claire, Oleary, Maria, Dixon, Maxine, Goodchild, Fiona, Twenlow, Rebecca, Pawley, Corinne, Ramadas, Arvind, Tregonning, Julie, Okeke, Olaku, Jackson, Wendy, Koumoutsos, Ioannis, George, Viji, Kunhunny, Swapna, Laverick, Sophie, Anderson, Isla, Smith, Sophie, Joyce, Joan, Janarthan, Sarala, Patel, Kamal, Ali, Mariam, Mhandu, Hilda, Rana, Aleem, Spears, Katherine, Teixeira, Joana, Mencias, Mark, Seaward, Abigail, Sousa, Jessica, Said, Nooria, Soomaroo, Mark, Raspa, Valentina, Tacouri, Asha, Reps, Nicholas, Martin, Rebecca, Samakomva, Tinashe, Selinger, Christian, Carbonell, Jenelyn, Onovira, Felicia, Quartey, Doris, L'Anson, Alice, Ashworth, Andrew, Bailey, Jessica, Dunn, Angie, Bespaloi, Gjuzel, Rasalan, Harold, Mahmood, Zahid, Campbell, Racheal, Marsh, Liane, Coughlan, Tricia, Jafar, Wisam, Marrs, Janet, McPheat, Christopher, Rahman, Monira, Davies, Sarah, Habibi, Ruth, Jessup-Dunton, Ellen, Joefield, Teishel, Layug, Reina, Patel, Vinod, Vere, Joanne, Turner, Victoria, Kilroy, Susan, Coulding, Martina, Clark, Martyn, McCormick, Jacqueline, Nisar, Attiya, Walker, Gareth, Atkins, Stacey, Growdon, Jasmine, George, Becky, McNeill, Charlotte, Reed, Bryony, Foulds, Angela, Marshall, Catherine, Allison, Michele, Dillon, Briony, Cooney, Rachel, Bennett, Lillie, Bowlas, Louise, Shariff, Sharafaath, Fraser, Aileen, Punnette, Dwayne, Lambert, Rebecca, Bishop-Hurman, Charlotte, Undrell, Elizabeth, Belfield, Katherine, Din, Said, Addleton, Catherine, Appleby, Marie, Brown, Johanna, Holding, Kathleen, Fraser, Catherine, Birkenshaw, Janice, Williams, Jodie, Maulion, Kamille, Lane, Meg, Kravale, Arita, Smith, Claud, Hooper, Patricia, deCaestecker, John, Watchorn, Olivia, Clarke, Ellie, Hayward, Chris, Inniss, Susan, Pritchard, Lucy, Rudge, Karen, Carney, Amanda, Griffee, Sarah, Andreyev, Jervoise, Babu, Sathish, Hayhurst, Caroline, Lockwood, Carol, Osborne, Lynn, Roper, Amanda, Warner, Karen, Hindle, Julia, Lawrence, Tara, Netherton, Kimberley, Watt, Caroline, Szymiczek, Kinga, Mehta, Shameer, Bell, James, Blad, William, Whitley, Lisa, Jastrub, Roman, Durai, Dhamaraj, Baker, Mark, John Sivamurugan, Elizabeth, Evans, Mim, Cummings, Fraser, Harris, Clare, Jones, Amy, Krauze, Liga, Rahmany, Sohail, Earl, Michelle, Vowles, Jenny, Torokwa, Audrey, Petrova, Mirela, Procter, Andrew, Stanley, Jo, Silvamoniz, Claudia, Bettey, Marion, Wahid, Amar, Morrison, Zoe, Thomas-Turner, Rhian, Yendle, Louise, Muller, Jennifer, Mitchell, Marcus, Kirkwood, John, Barnes, Anna, Chaudhary, Rakesh, Claridge, Melanie, Ellis, Chiara, Kemp, Cheryl, Tobi, Ogwa, Milton, Jentus, Johnston, Emma, Oblak, Metod, Winpenny, Carmen, Svensson, Marie-Louise, Godden, Jo, Ashhar, Marium, Alexander, Debbie, Covil, Kate, Derikx, Lauranne, Siakavellas, Sryros, Baxter, Helen, Robertson, Scott, Smith, Linda, Poulose, Beena, Colemam, Anne, Balint, Margareta, Rhys-Jones, Gareth, Watters, Helen, Begg, Susan, Grosalcalde, Beatriz, Coyle, Judy, Johns, Kerrie, Hughes, Rachel, Phipps, Janet, Taylor, Abigail, MacPhee, Catherine, Brooks, Suzanne, John, Jolene, Edwards, Michelle, Smith, Katie, Howard, Linda, Wood, Dianne, Muddu, Ajay, Barman, Laura, Mallinson, Janine, Neale, Tania, Ionita, Diana, Elliot, Kerry, Turnball, Alison, Thomas, Iola, Thomas, Alice, Andrews, Kelly, Sutton, Jonathon, Mulvaney Jones, Caroline, Roberts, Julia, Bishop, Jeannie, Liu, Zhigang, Le, Kaixing, Zhou, Xin, Alexander, James L, Lin, Simeng, Bewshea, Claire, Chanchlani, Neil, Nice, Rachel, McDonald, Timothy J, Lamb, Christopher A, Sebastian, Shaji, Kok, Klaartje, Lees, Charlie W, Hart, Ailsa L, Pollok, Richard C, Boyton, Rosemary J, Altmann, Daniel M, Pollock, Katrina M, Goodhand, James R, Kennedy, Nicholas A, Ahmad, Tariq, and Powell, Nick

Published
2023
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2. Predictors of Response to Vedolizumab in Patients with Ulcerative Colitis: Results from the Greek VEDO-IBD Cohort

Author

Bamias, Giorgos, Kokkotis, Georgios, Gizis, Michalis, Kapizioni, Christina, Karmiris, Konstantinos, Koureta, Evgenia, Kyriakos, Nikolaos, Leonidakis, Georgios, Makris, Konstantinos, Markopoulos, Panagiotis, Michalopoulos, Georgios, Michopoulos, Spyridon, Papaconstantinou, Ioannis, Polymeros, Dimitrios, Siakavellas, Spyros I., Triantafyllou, Konstantinos, Tsironi, Eftychia, Tsoukali, Emmanouela, Tzouvala, Maria, Viazis, Nikos, Xourafas, Vassileios, Zacharopoulou, Eirini, Zampeli, Evanthia, Zografos, Konstantinos, Papatheodoridis, George, and Mantzaris, Gerasimos

Published
2022
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4. Gastric polyps: a retrospective cohort analysis of 23,668 endoscopies indicates changing epidemiological and phenotypic characteristics

Author

Kapizioni, Christina, primary, Kourkoulis, Panagiotis, additional, Kartsoli, Sofia, additional, Koutoufaris, Georgios, additional, Giannelis, Panagiotis, additional, Mellos, Aristotelis, additional, Milioni, Konstantia, additional, Michalopoulos, George, additional, Vrakas, Spyridon, additional, and Xourgias, Vasileios, additional

Published
2024
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5. Biologic Therapy for Inflammatory Bowel Disease: Real-World Comparative Effectiveness and Impact of Drug Sequencing in 13 222 Patients within the UK IBD BioResource.

Author

Kapizioni, Christina, Desoki, Rofaida, Lam, Danielle, Balendran, Karthiha, Al-Sulais, Eman, Subramanian, Sreedhar, Rimmer, Joanna E, Negro, Juan De La Revilla, Pavey, Holly, Pele, Laetitia, Brooks, Johanne, Moran, Gordon W, Irving, Peter M, Limdi, Jimmy K, Lamb, Christopher A, Investigators, UK IBD BioResource, Parkes, Miles, and Raine, Tim

Abstract

Background and Aims This study compares the effectiveness of different biologic therapies and sequences in patients with inflammatory bowel disease [IBD] using real-world data from a large cohort with long exposure. Methods Demographic, disease, treatment, and outcome data were retrieved for patients in the UK IBD BioResource. Effectiveness of treatment was based on persistence free of discontinuation or failure, analysed by Kaplan–Meier survival analysis with inverse probability of treatment weighting to adjust for differences between groups. Results In total, 13 222 evaluable patients received at least one biologic. In ulcerative colitis [UC] first-line vedolizumab [VDZ] demonstrated superior effectiveness over 5 years compared to anti-tumour necrosis factor [anti-TNF] agents [ p  = 0.006]. VDZ was superior to both infliximab [IFX] and adalimumab [ADA] after ADA and IFX failure respectively [ p  < 0.001 and p  < 0.001]. Anti-TNF therapy showed similar effectiveness when used as first-line treatment, or after failure of VDZ. In Crohn's disease [CD] we found significant differences between first-line treatments over 10 years [ p  = 0.045], with superior effectiveness of IFX compared to ADA in perianal CD. Non-anti-TNF biologics were superior to a second anti-TNF after first-line anti-TNF failure in CD [ p  = 0.035]. Patients with UC or CD experiencing TNF failure due to delayed loss of response or intolerance had superior outcomes when switching to a non-anti-TNF biologic, rather than a second anti-TNF. Conclusions We provide real-world evidence to guide biologic selection and sequencing in a range of common scenarios. Our findings challenge current guidelines regarding drug selection after loss of response to first anti-TNF treatment. [ABSTRACT FROM AUTHOR]

Published
2024
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7. Results of the Eighth Scientific Workshop of ECCO: Prevention and Treatment of Postoperative Recurrence in Patients With Crohns Disease Undergoing an Ileocolonic Resection With Ileocolonic Anastomosis

Author

Ferrante, Marc, Pouillon, Lieven, Manosa, Miriam, Savarino, Edoardo, Allez, Matthieu, Kapizioni, Christina, Arebi, Naila, Carvello, Michele, Myrelid, Pär, De Vries, Annemarie C., European Crohns Colitis Org, Riviere, Pauline, Panis, Yves, Domenech, Eugeni, Ferrante, Marc, Pouillon, Lieven, Manosa, Miriam, Savarino, Edoardo, Allez, Matthieu, Kapizioni, Christina, Arebi, Naila, Carvello, Michele, Myrelid, Pär, De Vries, Annemarie C., European Crohns Colitis Org, Riviere, Pauline, Panis, Yves, and Domenech, Eugeni

Abstract

Despite the introduction of biological therapies, an ileocolonic resection is often required in patients with Crohns disease [CD]. Unfortunately, surgery is not curative, as many patients will develop postoperative recurrence [POR], eventually leading to further bowel damage and a decreased quality of life. The 8th Scientific Workshop of ECCO reviewed the available scientific data on both prevention and treatment of POR in patients with CD undergoing an ileocolonic resection, dealing with conventional and biological therapies, as well as non-medical interventions, including endoscopic and surgical approaches in case of POR. Based on the available data, an algorithm for the postoperative management in daily clinical practice was developed.

Published
2023
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8. Results of the Eighth Scientific Workshop of ECCO:Prevention and Treatment of Postoperative Recurrence in Patients With Crohn's Disease Undergoing an Ileocolonic Resection With Ileocolonic Anastomosis

Author

Ferrante, Marc, Pouillon, Lieven, Mañosa, Míriam, Savarino, Edoardo, Allez, Matthieu, Kapizioni, Christina, Arebi, Naila, Carvello, Michele, Myrelid, Pär, De Vries, Annemarie C., Dragoni, Gabriele, Allocca, Mariangela, Noor, Nurulamin M., Bislenghi, Gabriele, Hammoudi, Nassim, Verstockt, Bram, Brown, Steven, Oliveira Cunha, Melissa, Bemelman, Willem, Pellino, Gianluca, Kotze, Paulo Gustavo, Rivière, Pauline, Panis, Yves, Domènech, Eugeni, Ferrante, Marc, Pouillon, Lieven, Mañosa, Míriam, Savarino, Edoardo, Allez, Matthieu, Kapizioni, Christina, Arebi, Naila, Carvello, Michele, Myrelid, Pär, De Vries, Annemarie C., Dragoni, Gabriele, Allocca, Mariangela, Noor, Nurulamin M., Bislenghi, Gabriele, Hammoudi, Nassim, Verstockt, Bram, Brown, Steven, Oliveira Cunha, Melissa, Bemelman, Willem, Pellino, Gianluca, Kotze, Paulo Gustavo, Rivière, Pauline, Panis, Yves, and Domènech, Eugeni

Abstract

Despite the introduction of biological therapies, an ileocolonic resection is often required in patients with Crohn's disease [CD]. Unfortunately, surgery is not curative, as many patients will develop postoperative recurrence [POR], eventually leading to further bowel damage and a decreased quality of life. The 8th Scientific Workshop of ECCO reviewed the available scientific data on both prevention and treatment of POR in patients with CD undergoing an ileocolonic resection, dealing with conventional and biological therapies, as well as non-medical interventions, including endoscopic and surgical approaches in case of POR. Based on the available data, an algorithm for the postoperative management in daily clinical practice was developed.

Published
2023

9. ECCO Guidelines on Inflammatory Bowel Disease and Malignancies

Author

Gordon, Hannah, Biancone, Livia, Fiorino, Gionata, Katsanos, Konstantinos H, Kopylov, Uri, Sulais, Eman Al, Axelrad, Jordan E, Balendran, Karthiha, Burisch, Johan, de Ridder, Lissy, Derikx, Lauranne, Ellul, Pierre, Greuter, Thomas, Iacucci, Marietta, Di Jiang, Caroline, Kapizioni, Christina, Karmiris, Konstantinos, Kirchgesner, Julien, Laharie, David, Lobatón Ortega, Triana, Molnár, Tamás, Noor, Nurulamin M, Rao, Rohit, Saibeni, Simone, Scharl, Michael, Vavricka, Stephan R, Raine, Tim, Gordon, Hannah, Biancone, Livia, Fiorino, Gionata, Katsanos, Konstantinos H, Kopylov, Uri, Sulais, Eman Al, Axelrad, Jordan E, Balendran, Karthiha, Burisch, Johan, de Ridder, Lissy, Derikx, Lauranne, Ellul, Pierre, Greuter, Thomas, Iacucci, Marietta, Di Jiang, Caroline, Kapizioni, Christina, Karmiris, Konstantinos, Kirchgesner, Julien, Laharie, David, Lobatón Ortega, Triana, Molnár, Tamás, Noor, Nurulamin M, Rao, Rohit, Saibeni, Simone, Scharl, Michael, Vavricka, Stephan R, and Raine, Tim

Published
2023

11. Neutralising antibody potency against SARS-CoV-2 wild-type and omicron BA.1 and BA.4/5 variants in patients with inflammatory bowel disease treated with infliximab and vedolizumab after three doses of COVID-19 vaccine (CLARITY IBD): an analysis of a prospective multicentre cohort study

Author

Liu, Zhigang, primary, Le, Kaixing, additional, Zhou, Xin, additional, Alexander, James L, additional, Lin, Simeng, additional, Bewshea, Claire, additional, Chanchlani, Neil, additional, Nice, Rachel, additional, McDonald, Timothy J, additional, Lamb, Christopher A, additional, Sebastian, Shaji, additional, Kok, Klaartje, additional, Lees, Charlie W, additional, Hart, Ailsa L, additional, Pollok, Richard C, additional, Boyton, Rosemary J, additional, Altmann, Daniel M, additional, Pollock, Katrina M, additional, Goodhand, James R, additional, Kennedy, Nicholas A, additional, Ahmad, Tariq, additional, Powell, Nick, additional, Islam, Madiha, additional, Croft, Nick, additional, Cipriano, Bessie, additional, Francia, Caroline, additional, Khalid, Nosheen, additional, Kingston, Ashley, additional, Lee, Irish, additional, Lehmann, Anouk, additional, Naik, Kinnari, additional, Samuels, Kevin, additional, Plaatjies, Nicolene, additional, Khatun, Hafiza, additional, Bokth, Farjana, additional, Pabriaga, Elise, additional, Saich, Rebecca, additional, Cousins, Hayley, additional, Fraser, Wendy, additional, Thomas, Rachel, additional, Brown, Matthew, additional, White, Benjamin, additional, Kirkineziadis, Nikolaos, additional, Tilley, Bernadette, additional, Porter, Pennie, additional, Bryant, Rachel, additional, Robaczewska, Natalia, additional, Muhammed, Rafeeq, additional, Bi, Rehana, additional, Cotter, Catherine, additional, Grove, Jayne, additional, Hong, Kate, additional, Howman, Ruth, additional, Mitchell, Monica, additional, Clayton, Sophie, additional, Rogers, Louise, additional, Sultan, Sugrah, additional, Rooney, Melanie, additional, Cottrill, Charlotte, additional, Singh, Salil, additional, Dawe, Chris, additional, Hull, Robert, additional, Silva, Natalie, additional, Chadwick, Julie, additional, Robertson, Laura, additional, Manning, Jonathan, additional, Finlayson, Lauren, additional, Roebuck, Allison, additional, Dawson, Joy, additional, Sonwalkar, Sunil, additional, Chambers, Naomi, additional, Robinson, Matthew, additional, Haigh, Andrew, additional, Matapure, Lear, additional, Raine, Tim, additional, George, Varun, additional, Kapizioni, Christina, additional, Strongili, Konstantina, additional, Thompson, Tina, additional, Ahmed, Mohamed, additional, Kontos, Christos, additional, Dawson, Claire, additional, Bourges, Christophe, additional, Barbutti, Isabella, additional, Gozzard, Megan E, additional, Hendy, Philip, additional, Bull, Rhian, additional, Costa, Patricia, additional, Davey, Lisa, additional, Hannington, Hayley, additional, Nundlall, Kribashnie, additional, Martins, Catarina, additional, Avanzi, Laura, additional, Carungcong, Jaime, additional, Barr, Sabrina, additional, Appleby, Richard, additional, Johnson, Emma, additional, Shakweh, Eathar, additional, Phillis, Kath, additional, Gascoyne, Rachel, additional, Crowder, Amanda, additional, Whileman, Amanda, additional, London, Ian, additional, Grounds, Jenny, additional, Martin, Emmeline, additional, Pajak, Susie, additional, Price, Jude, additional, Cawley, Kathryn, additional, Powell, Sandra, additional, Kearsley, Nichola, additional, Dhar, Anjan, additional, Brown, Ellen, additional, Cowton, Amanda, additional, Stamp, Kimberley, additional, Warner, Ben, additional, Stuart, Carmel, additional, Lacey, Louise, additional, de Silva, Shanika, additional, Allcock, Clare, additional, Harvey, Philip, additional, Jones, Lesley, additional, Cooke, Elise, additional, Slater, Jayne, additional, King, Dominic, additional, Brooks, Johanne, additional, Baker, Pearl, additional, Beadle, Hannah, additional, Cruz, Carina, additional, Potter, Debbie, additional, Collum, Joe, additional, Masters, Farzana, additional, Kumar, Aashish, additional, Coetzee, Samantha, additional, Peiu, Mihaela, additional, Icke, Becky, additional, Williams, Jill, additional, Raj, Meena, additional, Gaynor, Edward, additional, Chadokufa, Sibongile, additional, Huggett, Bonita, additional, Meghari, Hamza, additional, El-Khouly, Sara, additional, Kiparissi, Fevronia, additional, Girshab, Waffa, additional, Russell-Walker, Lynda, additional, Jackson, Christopher, additional, Sidler, Sara, additional, Claridge, Andrew, additional, Fowler, Emily, additional, McCafferty, Laura, additional, Haxton, Lesley, additional, Irving, Peter, additional, Christodoulides, Karolina, additional, Clifford, Angela, additional, Dawson, Patrick, additional, Honap, Sailish, additional, Lim, Samuel, additional, Luber, Raphael, additional, Mahiouz, Karina, additional, Meade, Susanna, additional, Raymode, Parizade, additional, Reynolds, Rebecca, additional, Stanton, Anna, additional, Tripoli, Sherill, additional, Hare, Naomi, additional, Odukwe, Sopuluchukwu, additional, Balachandran, Senthuran, additional, North, Emma, additional, North, Jessica, additional, Browne, Bria, additional, Cordle, Jessica, additional, Jameson, Ella, additional, Siaw, Yih Harn, additional, Manzano, Lane, additional, Segal, Jonathan, additional, Al-Bakir, Ibrahim, additional, Khakoo, Imran, additional, Portukhay, Sofiya, additional, Thoua, Nora, additional, Davidson, Katherine, additional, Miah, Jagrul, additional, Canclini, Lisa, additional, Hall, Alex, additional, Furreed, Hassina, additional, Mitchell-Inwang, Christine, additional, Hayes, Melony, additional, Myers, Sally, additional, Talbot, Alison, additional, Turnbull, Jack, additional, Whitehead, Emma, additional, Stamp, Katie, additional, Pattinson, Alison, additional, Mathew, Verghese, additional, Sherris, Leanne, additional, Wilcox, Julie, additional, Ramachandran, Sankaranarayanan, additional, Robertson, Hayley, additional, Harvey, Angela, additional, Hicks, Lucy, additional, Byrne, Tara-Marie, additional, Cabreros, Leilani, additional, Downing-Wood, Hannah, additional, Hunter, Sophie, additional, Saifuddin, Mohammad Aamir, additional, Prabhudev, Hemanth, additional, Balarajah, Sharmili, additional, Krucznski, Jan, additional, Driva, Kalliopi, additional, D'Mello, Andrea, additional, Shah, Parith, additional, Castro-Seoane, Rocio, additional, Ibraheim, Hajir, additional, Constable, Laura E, additional, Lo, Jonathan W, additional, Torkizadeh, Melissa, additional, Hermangild, Sherine K, additional, Sutherland, Helen, additional, Wilhelmsen, Elva, additional, Mackintosh, Katherine, additional, Verma, Ajay M, additional, Sebastian, Juliemol, additional, Peerally, Mohammad Farhad, additional, Guerdette, Anne-marie, additional, Coburn, Susan, additional, Novem lam, Ching Yee, additional, Durrant, Donna, additional, Schaefer, Belinda, additional, Serna, Solange, additional, Shahzad, Muhammad, additional, Kent, Alexandra, additional, Choong, Lee Meng, additional, Pantaloni, Benedetta, additional, Ravdas, Pantelis, additional, Vadamalayan, Babu, additional, Foley, Stephen, additional, Arnold, Becky, additional, Heeley, Cheryl, additional, Lovegrove, Wayne, additional, Sowton, Donna, additional, Allsop, Lynne, additional, Gregory, Heidi, additional, Gill, Mandy, additional, Holmes, Megan, additional, Balan, Valeria, additional, Smith, Susan, additional, Turner, Sarah, additional, Smith, Philip J, additional, Steel, Alan, additional, Bretland, Giovanna, additional, King, Sarah, additional, Lofthouse, Martina, additional, Rigby, Lindsey, additional, Subramanian, Sreedhar, additional, Tyrer, David, additional, Martin, Kate, additional, Probert, Christopher, additional, Kamperidis, Nikolaos, additional, Adedoyin, Temi, additional, Baden, Manisha, additional, Brown, Jeannette, additional, Chacko, Feba, additional, Young, Lisa, additional, Cicchetti, Michela, additional, Saifuddin, Mohammad, additional, Yesupatham, Priya, additional, Gowda, Rohit, additional, Williams, Maureen, additional, Kemp, Karen, additional, Akhand, Rima, additional, Gray, Glaxy, additional, John, Anu, additional, John, Maya, additional, Mohammed, Tasnim, additional, Sathe, Diamond, additional, Jones, Natasha, additional, Soren, Jennifer, additional, Sprakes, Michael, additional, Burton, Julie, additional, Kane, Patricia, additional, Lupton, Stephanie, additional, Bartholomew, Jacqueline, additional, Denis, Elizabeth, additional, Daniels, Alison, additional, MacFaul, George, additional, Scaletta, Diane, additional, Siamia, Loria, additional, Williams, Felicity, additional, Green, Chloe, additional, Ver, Zeljka, additional, Lamb, Chris, additional, Doona, Mary, additional, Hogg, Ashleigh, additional, Jeffrey, Lesley, additional, King, Andrew, additional, Speight, R Alexander, additional, Doyle, Jennifer, additional, Owen, Ruth, additional, Haworth, Jenny, additional, Patterson, Linda, additional, Varnaulasingam, Vithusa, additional, Mowat, Craig, additional, Rice, Debbie, additional, MacFarlane, Susan, additional, MacLeod, Anne, additional, Mohammed, Samera, additional, Murray, Shona, additional, Elliott, Anne, additional, Anne Morris, Mary, additional, Coke, Louise, additional, Hindle, Grace, additional, Kolokouri, Eirini, additional, Wright, Catherine, additional, Lee, Claire, additional, Ward, Nicola, additional, Dann, Adele, additional, Lockett, Melanie, additional, Cranfield, Charlotte, additional, Jennings, Louise, additional, Srivastava, Ankur, additional, Ward, Lana, additional, Jeynes, Nouf, additional, Ranga, Poonam, additional, Rajasekhar, Praveen, additional, Gallagher, Lisa, additional, Ward, Jill, additional, Basnett, Rae, additional, Murphy, Judy, additional, Parking, Lauren, additional, Lawson, Emma, additional, Short, Stacey, additional, Devadason, David, additional, Moran, Gordon, additional, Khan, Neelam, additional, Tarr, Lauren, additional, Olivia, Charmaine, additional, Warbarton, Samantha, additional, Kelly, Sian, additional, Limdi, Jimmy, additional, Goulden, Kay, additional, Javed, Asad, additional, McKenzie, Lauren, additional, Melville, Julie, additional, Liu, Eleanor, additional, Sabine, Joseph, additional, Jacob, Patricia, additional, McSorland, Denise, additional, Schofield, Nick, additional, Cornwall, Lisa, additional, Quirke, James, additional, Crook, Emma, additional, Turner, Anne, additional, Bhandari, Pradeep, additional, Baker-Moffatt, Michelle, additional, Dash, Joanne, additional, Le Poidevin, Alison, additional, Downe, Hayley, additional, Bombeo, Lucille, additional, Blackman, Helen, additional, Smith, Rebecca, additional, Wiles, Alan, additional, Bloxham, Hannah, additional, Dias, Jose, additional, Nadar, Evelyn, additional, Curgenven, Hollie, additional, Gilham, Ellie, additional, Macdonald, Jonathan, additional, Finan, Shona, additional, McMeeken, Faye, additional, Mahmood, Misbah, additional, Shields, Stephanie, additional, Seenan, John Paul, additional, DeSilva, Des, additional, Malkakorpi, Susanna, additional, Carson, Rachel, additional, Lawrence, Holly, additional, Boateng, Ofori, additional, Kpodo, Felix, additional, Whiteoak, Simon, additional, Edger-Earley, Kelli, additional, Vamplew, Luke, additional, Samways, Joanna, additional, Roffe, Sue, additional, Ingram, Sarah, additional, James, Joel, additional, Botfield, Sharon, additional, Hammonds, Fiona, additional, James, Clare, additional, Berry, Zoe, additional, Aspinall, Gemma, additional, Hawkins, Sarah, additional, Parkinson, Marian, additional, Gardner-Thorpe, Helen, additional, Marriott, Suzie, additional, Redstone, Clare, additional, Windak, Halina, additional, Adam, Ana-Marie, additional, Mabb, Hannah, additional, Stevenson, Emma, additional, Record, Jessica, additional, Murray, Charles, additional, Diaba, Cynthia, additional, Joseph, Fexy, additional, Pakou, Glykeria, additional, Gleeson, Yvonne, additional, Nunag, Annalyn, additional, Berrill, James, additional, Stroud, Natalie, additional, Pothecary, Carla, additional, Roche, Lisa, additional, Turner, Keri, additional, Deering, Lisa, additional, Israel, Lynda, additional, Baker, Evelyn, additional, Nash, Maxine, additional, Fagbemi, Andrew, additional, Jennings, Felicia, additional, Mayor, Imelda, additional, Wilson, Jill, additional, Wheeler, Alice, additional, Phillips, Nicola, additional, Gordon, John, additional, Levell, Emma, additional, Zagalo, Silvia, additional, Hoad, Ina, additional, Anil, Bindu, additional, Russell, Richard, additional, Henderson, Paul, additional, Millar, Margaret, additional, Alexakis, Christopher, additional, Michalak, Natalia, additional, Marriott, Cheryl, additional, Stone, Sarah, additional, Pristopan, Veronika, additional, Saunders, John, additional, Burton, Helen, additional, Cambridge, Vanessa, additional, Clark, Tonia, additional, Ekblad, Charlotte, additional, Hierons, Sarah, additional, Katebe, Joyce, additional, Saunsbury, Emma, additional, Perry, Rachel, additional, Brookes, Matthew, additional, Davies, Kathryn, additional, Green, Marie, additional, Plumbe, Ann, additional, Ormerod, Clare, additional, Christensen, Helen, additional, Howlett, Hannah, additional, Keen, Anne, additional, Ogor, Jonathan, additional, Greenhaigh, Marie, additional, Knowles, Karen, additional, Yin, Shanzi, additional, Poulaka, Maria, additional, Anthony, Alpha, additional, Newitt, Emily, additional, Trim, Fiona, additional, Casey, Ruth, additional, Seymour, Katherine, additional, Reed, Catherine, additional, Joy, Lijo, additional, Fogden, Edward, additional, Russell, Kalisha, additional, Hussain, Samia, additional, Phillips, Anne, additional, Abdulla, Muaad, additional, Butterworth, Jeff, additional, Adams, Colene, additional, Carnahan, Mandy, additional, Buckingham, Elizabeth, additional, Childs, Danielle, additional, Magness, Alison, additional, Stickley, Jo, additional, Motherwell, Nichola, additional, Tonks, Louise, additional, Gibson, Hannah, additional, Wistance, Kate, additional, Thomas, Caradog, additional, Brinkworth, Elaine, additional, Connor, Lynda, additional, Cook, Amanda, additional, Rees, Tabitha, additional, Harford, Rachel, additional, Farley, Sean, additional, Jones, Marie, additional, Wesley, Emma, additional, Moss, Alison, additional, Lucas, Jacob, additional, Lorimer, Claire, additional, Oleary, Maria, additional, Dixon, Maxine, additional, Goodchild, Fiona, additional, Twenlow, Rebecca, additional, Pawley, Corinne, additional, Ramadas, Arvind, additional, Tregonning, Julie, additional, Okeke, Olaku, additional, Jackson, Wendy, additional, Koumoutsos, Ioannis, additional, George, Viji, additional, Kunhunny, Swapna, additional, Laverick, Sophie, additional, Anderson, Isla, additional, Smith, Sophie, additional, Joyce, Joan, additional, Janarthan, Sarala, additional, Patel, Kamal, additional, Ali, Mariam, additional, Mhandu, Hilda, additional, Rana, Aleem, additional, Spears, Katherine, additional, Teixeira, Joana, additional, Mencias, Mark, additional, Seaward, Abigail, additional, Sousa, Jessica, additional, Said, Nooria, additional, Soomaroo, Mark, additional, Raspa, Valentina, additional, Tacouri, Asha, additional, Reps, Nicholas, additional, Martin, Rebecca, additional, Samakomva, Tinashe, additional, Selinger, Christian, additional, Carbonell, Jenelyn, additional, Onovira, Felicia, additional, Quartey, Doris, additional, L'Anson, Alice, additional, Ashworth, Andrew, additional, Bailey, Jessica, additional, Dunn, Angie, additional, Bespaloi, Gjuzel, additional, Rasalan, Harold, additional, Mahmood, Zahid, additional, Campbell, Racheal, additional, Marsh, Liane, additional, Coughlan, Tricia, additional, Jafar, Wisam, additional, Marrs, Janet, additional, McPheat, Christopher, additional, Rahman, Monira, additional, Davies, Sarah, additional, Habibi, Ruth, additional, Jessup-Dunton, Ellen, additional, Joefield, Teishel, additional, Layug, Reina, additional, Patel, Vinod, additional, Vere, Joanne, additional, Turner, Victoria, additional, Kilroy, Susan, additional, Coulding, Martina, additional, Clark, Martyn, additional, McCormick, Jacqueline, additional, Nisar, Attiya, additional, Walker, Gareth, additional, Atkins, Stacey, additional, Growdon, Jasmine, additional, George, Becky, additional, McNeill, Charlotte, additional, Reed, Bryony, additional, Foulds, Angela, additional, Marshall, Catherine, additional, Allison, Michele, additional, Dillon, Briony, additional, Cooney, Rachel, additional, Bennett, Lillie, additional, Bowlas, Louise, additional, Shariff, Sharafaath, additional, Fraser, Aileen, additional, Punnette, Dwayne, additional, Lambert, Rebecca, additional, Bishop-Hurman, Charlotte, additional, Undrell, Elizabeth, additional, Belfield, Katherine, additional, Din, Said, additional, Addleton, Catherine, additional, Appleby, Marie, additional, Brown, Johanna, additional, Holding, Kathleen, additional, Fraser, Catherine, additional, Birkenshaw, Janice, additional, Williams, Jodie, additional, Maulion, Kamille, additional, Lane, Meg, additional, Kravale, Arita, additional, Smith, Claud, additional, Hooper, Patricia, additional, deCaestecker, John, additional, Watchorn, Olivia, additional, Clarke, Ellie, additional, Hayward, Chris, additional, Inniss, Susan, additional, Pritchard, Lucy, additional, Rudge, Karen, additional, Carney, Amanda, additional, Griffee, Sarah, additional, Andreyev, Jervoise, additional, Babu, Sathish, additional, Hayhurst, Caroline, additional, Lockwood, Carol, additional, Osborne, Lynn, additional, Roper, Amanda, additional, Warner, Karen, additional, Hindle, Julia, additional, Lawrence, Tara, additional, Netherton, Kimberley, additional, Watt, Caroline, additional, Szymiczek, Kinga, additional, Mehta, Shameer, additional, Bell, James, additional, Blad, William, additional, Whitley, Lisa, additional, Jastrub, Roman, additional, Durai, Dhamaraj, additional, Baker, Mark, additional, John Sivamurugan, Elizabeth, additional, Evans, Mim, additional, Cummings, Fraser, additional, Harris, Clare, additional, Jones, Amy, additional, Krauze, Liga, additional, Rahmany, Sohail, additional, Earl, Michelle, additional, Vowles, Jenny, additional, Torokwa, Audrey, additional, Petrova, Mirela, additional, Procter, Andrew, additional, Stanley, Jo, additional, Silvamoniz, Claudia, additional, Bettey, Marion, additional, Wahid, Amar, additional, Morrison, Zoe, additional, Thomas-Turner, Rhian, additional, Yendle, Louise, additional, Muller, Jennifer, additional, Mitchell, Marcus, additional, Kirkwood, John, additional, Barnes, Anna, additional, Chaudhary, Rakesh, additional, Claridge, Melanie, additional, Ellis, Chiara, additional, Kemp, Cheryl, additional, Tobi, Ogwa, additional, Milton, Jentus, additional, Johnston, Emma, additional, Oblak, Metod, additional, Winpenny, Carmen, additional, Svensson, Marie-Louise, additional, Godden, Jo, additional, Ashhar, Marium, additional, Alexander, Debbie, additional, Covil, Kate, additional, Derikx, Lauranne, additional, Siakavellas, Sryros, additional, Baxter, Helen, additional, Robertson, Scott, additional, Smith, Linda, additional, Poulose, Beena, additional, Colemam, Anne, additional, Balint, Margareta, additional, Rhys-Jones, Gareth, additional, Watters, Helen, additional, Begg, Susan, additional, Grosalcalde, Beatriz, additional, Coyle, Judy, additional, Johns, Kerrie, additional, Hughes, Rachel, additional, Phipps, Janet, additional, Taylor, Abigail, additional, MacPhee, Catherine, additional, Brooks, Suzanne, additional, John, Jolene, additional, Edwards, Michelle, additional, Smith, Katie, additional, Howard, Linda, additional, Wood, Dianne, additional, Muddu, Ajay, additional, Barman, Laura, additional, Mallinson, Janine, additional, Neale, Tania, additional, Ionita, Diana, additional, Elliot, Kerry, additional, Turnball, Alison, additional, Thomas, Iola, additional, Thomas, Alice, additional, Andrews, Kelly, additional, Sutton, Jonathon, additional, Mulvaney Jones, Caroline, additional, Roberts, Julia, additional, and Bishop, Jeannie, additional

Published
2023
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12. ECCO Guidelines on Inflammatory Bowel Disease and Malignancies

Author

Gordon, Hannah, Biancone, Livia, Fiorino, Gionata, Katsanos, Konstantinos H, Kopylov, Uri, Sulais, Eman Al, Axelrad, Jordan E, Balendran, Karthiha, Burisch, Johan, de Ridder, Lissy, Derikx, Lauranne, Ellul, Pierre, Greuter, Thomas, Iacucci, Marietta, Di Jiang, Caroline, Kapizioni, Christina, Karmiris, Konstantinos, Kirchgesner, Julien, Laharie, David, Lobatón Ortega, Triana, Molnár, Tamás, Noor, Nurulamin M, Rao, Rohit, Saibeni, Simone, Scharl, Michael, Vavricka, Stephan R, Raine, Tim, University of Zurich, and Pediatrics

Subjects
10219 Clinic for Gastroenterology and Hepatology, All institutes and research themes of the Radboud University Medical Center, Gastroenterology, 610 Medicine & health, General Medicine, Inflammatory diseases Radboud Institute for Molecular Life Sciences [Radboudumc 5]
Abstract

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Published
2022
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13. EUS-Guided Diagnosis of Gastric Subepithelial Lesions, What Is New?

Author

Vasilakis, Thomas, Ziogas, Dimitrios, Tziatzios, Georgios, Gkolfakis, Paraskevas, Koukoulioti, Eleni, Kapizioni, Christina, Triantafyllou, Konstantinos, Facciorusso, Antonio, and Papanikolaou, Ioannis S.

Subjects
GASTRIC mucosa, ENDOSCOPIC ultrasonography, ARTIFICIAL intelligence, DIAGNOSIS, ELASTOGRAPHY
Abstract

Gastric subepithelial lesions (SELs) are intramural lesions that arise underneath the gastric mucosa. SELs can be benign, but can also be malignant or have malignant potential. Therefore, correct diagnosis is crucial. Endosonography has been established as the diagnostic gold standard. Although the identification of some of these lesions can be carried out immediately, solely based on their echo characteristics, for certain lesions histological examination is necessary. Sometimes histology can be inconclusive, especially for smaller lesions. Therefore, new methods have been developed in recent years to assist decision making, such as contrast enhanced endosonography, EUS elastography, and artificial intelligence systems. In this narrative review we provide a complete overview of the gastric SELs and summarize the new data of the last ten years concerning the diagnostic advances of endosonography on this topic. [ABSTRACT FROM AUTHOR]

Published
2023
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14. Comparative performance and external validation of three different scores in predicting inadequate bowel preparation among Greek inpatients undergoing colonoscopy.

Author

Gkolfakis, Paraskevas, Kapizioni, Christina, Tziatzios, Georgios, Facciorusso, Antonio, Frazzoni, Leonardo, Thomopoulos, Konstantinos, Potamianos, Spyros, Christodoulou, Dimitrios, Papadopoulos, Vasilios, Fuccio, Lorenzo, Hassan, Cesare, and Triantafyllou, Konstantinos

Subjects
*BOWEL preparation (Procedure), *RECEIVER operating characteristic curves, *COLONOSCOPY, *AKAIKE information criterion
Abstract

Background Predictive scores aim to predict bowel preparation adequacy among hospitalized patients undergoing colonoscopy. We evaluated the comparative efficacy of these scores in predicting inadequate bowel cleansing in a cohort of Greek inpatients. Methods We performed a post hoc analysis of data generated from a cohort of inpatients undergoing colonoscopy in 4 tertiary Greek centers to validate the 3 models currently available (models A, B and C). We used the Akaike information criterion to quantify the performance of each model, while Harrell's C-index, as the area under the receiver operating characteristics curve (AUC), verified the discriminative ability to predict inadequate bowel prep. Primary endpoint was the comparison of performance among models for predicting inadequate bowel cleansing. Results Overall, 261 patients--121 (46.4%) female, 100 (38.3%) bedridden, mean age 70.7±15.4 years--were included in the analysis. Model B showed the highest performance (Harrell's C-index: AUC 77.2% vs. 72.6% and 57.5%, compared to models A and C, respectively). It also achieved higher performance for the subgroup of mobilized inpatients (Harrell's C-index: AUC 72.21% vs. 64.97% and 59.66%, compared to models A and C, respectively). Model B also performed better in predicting patients with incomplete colonoscopy due to inadequate bowel preparation (Harrell's C-index: AUC 74.23% vs. 69.07% and 52.76%, compared to models A and C, respectively). Conclusions Predictive model B outperforms its comparators in the prediction of inpatients with inadequate bowel preparation. This model is particularly advantageous when used to evaluate mobilized inpatients. [ABSTRACT FROM AUTHOR]

Published
2023
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15. The burden and management of anemia in Greek patients with inflammatory bowel disease: a retrospective, multicenter, observational study

Author

Foteinogiannopoulou, Kalliopi Karmiris, Konstantinos Axiaris, Georgios Velegraki, Magdalini Gklavas, Antonios Kapizioni, Christina Karageorgos, Charalabos Kateri, Christina and Katsoula, Anastasia Kokkotis, Georgios Koureta, Evgenia and Lamouri, Charikleia Markopoulos, Panagiotis Palatianou, Maria and Pastras, Ploutarchos Fasoulas, Konstantinos Giouleme, Olga and Zampeli, Evanthia Theodoropoulou, Aggeliki Theocharis, Georgios Thomopoulos, Konstantinos Karatzas, Pantelis and Katsanos, Konstantinos H. Kapsoritakis, Andreas Kourikou, Anastasia Mathou, Nikoleta Manolakopoulos, Spilios and Michalopoulos, Georgios Michopoulos, Spyridon Boubonaris, Alexandros Bamias, Giorgos Papadopoulos, Vasileios and Papatheodoridis, George Papaconstantinou, Ioannis Pachiadakis, Ioannis Soufleris, Konstantinos Tzouvala, Maria Triantos, Christos Tsironi, Eftychia Christodoulou, Dimitrios K. and Koutroubakis, Ioannis E. Hellenic Grp Study IBD

Subjects
hemic and lymphatic diseases, digestive system, digestive system diseases
Abstract

Background: Anemia is a common extraintestinal manifestation of Inflammatory Bowel Disease (IBD) affecting negatively the patients’ quality of life. The aim of this study was to determine the frequency and real-life management of anemia in IBD patients in Greece. Methods: This study was conducted in 17 Greek IBD referral centers. Demographic, clinical, laboratory, IBD and anemia treatment data were collected and analyzed retrospectively. Results: A total of 1394 IBD patients [560 ulcerative colitis (UC), 834 Crohn’s disease (CD)] were enrolled. Anemia at any time was reported in 687 (49.3%) patients of whom 413 (29.6%) had episodic and 274 (19.7%) had recurrent/persistent anemia. Anemia was diagnosed before IBD in 45 (6.5%), along with IBD in 269 (39.2%) and after IBD in 373 (54.3%) patients. In the multivariate analysis the presence of extraintestinal manifestations (p = 0.0008), IBD duration (p = 0.026), IBD related surgeries and hospitalizations (p = 0.026 and p = 0.004 accordingly) were risk factors of recurrent/persistent anemia. Serum ferritin was measured in 839 (60.2%) IBD patients. Among anemic patients, 535 (77.9%) received treatment. Iron supplementation was administered in 485 (90.6%) patients, oral in 142 (29.3%) and intravenous in 393 (81%). Conclusions: The frequency of anemia in IBD patients, followed at Greek referral centers, is approximately 50%. Development of recurrent/persistent anemia may be observed in 20% of cases and is independently associated with the presence of extraintestinal manifestations, IBD duration, IBD related surgeries and hospitalizations. Anemia treatment is administered in up to [Formula: see text] of anemia IBD patients with the majority of them receiving iron intravenously.

Published
2021

16. The burden and management of anemia in Greek patients with inflammatory bowel disease: a retrospective, multicenter, observational study (vol 21, 269, 2021)

Author

Foteinogiannopoulou, Kalliopi Karmiris, Konstantinos Axiaris, Georgios Velegraki, Magdalini Gklavas, Antonios Kapizioni, Christina Karageorgos, Charalabos Kateri, Christina and Katsoula, Anastasia Kokkotis, Georgios Koureta, Evgenia and Lamouri, Charikleia Markopoulos, Panagiotis Palatianou, Maria and Pastras, Ploutarchos Fasoulas, Konstantinos Giouleme, Olga and Zampeli, Evanthia Theodoropoulou, Aggeliki Theocharis, Georgios Thomopoulos, Konstantinos Karatzas, Pantelis and Katsanos, Konstantinos H. Kapsoritakis, Andreas Kourikou, Anastasia Mathou, Nikoleta Manolakopoulos, Spilios and Michalopoulos, Georgios Michopoulos, Spyridon Boubonaris, Alexandros Bamias, Giorgos Papadopoulos, Vasileios and Papatheodoridis, George Papaconstantinou, Ioannis Pachiadakis, Ioannis Soufleris, Konstantinos Tzouvala, Maria Triantos, Christos Tsironi, Eftychia Christodoulou, Dimitrios K. and Koutroubakis, Ioannis E. Hellenic Grp Study IBD

Published
2021

17. Predictors of Response to Vedolizumab in Patients with Ulcerative Colitis: Results from the Greek VEDO-IBD Cohort

Author

Bamias, Giorgos, primary, Kokkotis, Georgios, additional, Gizis, Michalis, additional, Kapizioni, Christina, additional, Karmiris, Konstantinos, additional, Koureta, Evgenia, additional, Kyriakos, Nikolaos, additional, Leonidakis, Georgios, additional, Makris, Konstantinos, additional, Markopoulos, Panagiotis, additional, Michalopoulos, Georgios, additional, Michopoulos, Spyridon, additional, Papaconstantinou, Ioannis, additional, Polymeros, Dimitrios, additional, Siakavellas, Spyros I., additional, Triantafyllou, Konstantinos, additional, Tsironi, Eftychia, additional, Tsoukali, Emmanouela, additional, Tzouvala, Maria, additional, Viazis, Nikos, additional, Xourafas, Vassileios, additional, Zacharopoulou, Eirini, additional, Zampeli, Evanthia, additional, Zografos, Konstantinos, additional, Papatheodoridis, George, additional, and Mantzaris, Gerasimos, additional

Published
2021
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18. Κυκλοφορούντα miRNA σαν πιθανοί βιοδείκτες της ανταπόκρισης της θεραπείας με anti-TNF σε ασθενείς με ΙΦΝΕ

Author

Kapizioni Christina

Subjects
Health Sciences, Επιστήμες Υγείας
Abstract

Εισαγωγή Οι Ιδιοπαθείς Φλεγμονώδεις Νόσοι του Εντέρου (ΙΦΝΕ) αποτελούν σημαντικό αίτιο νοσηρότητας στο σύγχρονο κόσμο, επηρεάζοντας κυρίως νέες και παραγωγικές ηλικιακές ομάδες. Η αιτιολογία τους δεν έχει αποσαφηνισθεί αλλά φαίνεται να προκύπτουν από ανώμαλη ανοσολογική απόκριση σε περιβαλλοντικά ερεθίσματα γενετικά προδιαθετιμένων ατόμων. Η είσοδος των βιολογικών παραγόντων στη φαρέτρα των θεραπευτικών επιλογών βελτιστοποίησε την πρόγνωση των ασθενών. Παρα ταύτα όμως παραμένει ένα όχι αμελητέο ποσοστό αυτών που δεν ανταποκρίνεται στη θεραπεία ταυτόχρονα όμως εκτίθεται στις ανεπιθύμητες δράσεις των φαρμάκων αυτών. Σε μια εποχή όπου οι -βιολογικές και μη- σύγχρονες θεραπείς αυξάνονται και στοχεύοντας στην επίτευξη του ιδανικού κλινικού αποτελέσματος με τις λιγότερες παρενέργειες για τον ασθενή, καθίσταται αναγκαία η ανεύρεση βιοδεικτών, εύκολων και επαναλήψιμων στη χρήση, για την πρόβλεψη της ανταπόκρισης στη θεραπεία. Με τους κλινικούς και ορολογικούς δείκτες να έχουν περιορισμένη τέτοια ικάνοτητα, η αναζήτηση στρέφεται προς γενετικούς και επιγενετικούς δείκτες. Σκοπός της μελέτης Η αναζήτηση συσχέτισης πολυμορφισμών σε microRNAs - rs2910164 , rs11 614913, rs113054794, και rs188519172- και της απάντησης στη θεραπεία με αντι-TNF ασθενών με νόσο Crohn. Μέθοδοι Ασθενείς με νόσο Crohn, βάσει κλινικών, ενδοσκοπικών, απεικονιστικών και ιστολογικών κριτηρίων, και οι οποίοι θα ελάμβαναν αντι-TNF παράγοντα συμπεριλήφθηκαν στη μελέτη. Έλαβαν όλοι infliximab ή adalimumab ενδοφλέβια/υποδόρια στις διεθνώς θεσμοθετημένες δόσεις και χρονικά διαστήματα. Η κλινική και ορολογική απάντηση ταυτοποιήθηκε με τους δείκτες Harvey-Bradshaw (ΗΒΙ) και CRP αντίστοιχα. Η ενδοσκοπική ανταπόκριση αξιολογήθηκε με ειλεοκολονοσκόπηση την εβδομάδα 12-20 μετά την έναρξη της θεραπείας. Οι αλλαγές στην ενδοσκοπική εικόνα συγκρινόμενες με αυτές της αρχικής ενδοσκόπησης κατηγοριοποιήθηκαν σε 4 κατηγορίες και οι ασθενείς χωρίσθηκαν σε ανταποκριθέντες και μη. Από περιφερικό αίμα εκχυλίστηκε γενωμικό DNA και ακολούθησε γενετική ανάλυση. Αποτελέσματα Εκατόν επτά ασθενείς συμπεριλήφθηκαν στη μελέτη. Εβδομήντα δύο (67.3%) ασθενείς θεωρήθηκαν ως πλήρως ανταποκριθέντες, 22 (20.5%) ως μερικώς ενώ 13 (12.1%) ως πρωτογενώς μη ανταποκριθέντες. Η ανταπόκριση στη θεραπεία με βιολογικό παράγοντα δεν διέφερε μεταξύ των ασθενών με διαφορετικά χαρακτηριστικά όπως ηλικία, φύλο, διάρκεια ή έκταση της νόσου ενώ υπήρξε συνάφεια μεταξύ του δείκτη ΗΒΙ και των επιπέδων της CRP με την απάντηση στη θεραπεία. Σχετικά με τη συχνότητα των πολυμορφισμών rs2910164, rs11614913, και rs188519172 των miR-146, miR-196a και miR-224 αντίστοιχα δεν αναδείχθηκε καμία στατιστικά σημαντική διαφορά μεταξύ των πλήρως, μερικώς και των μη ανταποκριθέντων ασθενών στη θεραπεία με αντι-TNF. Μάλιστα ο γονότυπος CC του rs2910164 δεν ανιχνεύθηκε σε κανέναν ασθνενή της μελέτης. Σχετικά με τον πολυμορφισμό rs113054794 του miR-221, ο φυσιολογικός γονότυπος CC ήταν ο μόνος που ανευρέθη σε όλους τους ασθενείς της μελέτης, υποδεικνύοντας ότι αυτός ο πολυμορφισμός πιθανώς είναι πολύ σπάνιος στους Καυκάσιους. Συμπέρασμα Καμία συσχέτιση δεν αναδείχθηκε μεταξύ των μελετώμενων πολυμορφισμών και της απάντησης στην αντι-TNF θεραπεία ασθενών με νόσο Crohn. Ο πολυμορφισμός rs113054794 δεν ανιχνεύθηκε στον πληθυσμό μας. Introduction Inflammatory bowel disease (IBD) constitutes an important cause of morbidity in the modern world, affecting mainly young and productive age groups. Their aitiology is partly unclear but it is hypothesized that it arises from a combination of genetic susceptibility and environmental factors that trigger an inappropriate mucosal inflammatory response. Anti-TNF agents have revolutionized IBD therapy nonetheless there still exists a non negligible percentage of patients who never respond but are exposed to biologic therapy side effects. In an era when biologic and non- biologic therapies are constantly increasing and while we aim at achieving the ideal clinical result with the least side effects for each patient, identification of new, easy to use biomarkers is considered almost mandatory. Clinical and serological biomarkers show limited such capability thus searching is headed towards genetic and epigenetic markers. Aim of study To investigate the correlation between rs2910164, rs11 614913, rs113054794, and rs188519172 miRNA polymorphisms and response to anti-TNF treatment in patients with Crohn's disease (CD). Methods One hundred seven patients with CD based on standard clinical, endoscopic, radiological, and pathological criteria were included in the study. They all received infliximab or adalimumab intravenously or subcutaneously at standard induction doses as per international guidelines. Clinical and biochemical response was assessed using the Harvey-Bradshaw index and CRP levels respectively. Endoscopic response was evaluated by ileocolonoscopy at week 12-20 of therapy. The changes in endoscopic appearance compared to baseline were classified into four categories, and patients were classified as responders and non-responders. Whole peripheral blood was extracted and genotyping was performed by PCR. Results One hundred and seven patients were included in the study. Seventy two (67.3%) patients were classified as complete responders, 22 (20.5%) as partial while 13 (12.1%) were primary non-responders. No correlation was detected between response to anti-TNF agents and patients' characteristics such as gender, age and disease duration while clinical and biochemical indexes used were associated with endoscopic response. Concerning prevalence of rs2910164, rs11614913, and rs188519172 polymorphisms of miR-146, miR-196a and miR-224 respectively no statistically important difference was found between complete, partial, and non-responders to anti-TNF treatment. Actually CC genotype of rs2910164 was not detected in any patient. Regarding rs113054794 of miR-221, normal CC genotype was the only one detected in all studied patients, suggesting this polymorphism is highly rare in the studied population. Conclusion No correlation was detected between studied polymorphisms and patients' response to anti-TNF treatment. Polymorphism rs113054794 was not detected in our population.

Published
2019

19. The burden and management of anemia in Greek patients with inflammatory bowel disease: a retrospective, multicenter, observational study.

Author

Foteinogiannopoulou, Kalliopi, Karmiris, Konstantinos, Axiaris, Georgios, Velegraki, Magdalini, Gklavas, Antonios, Kapizioni, Christina, Karageorgos, Charalabos, Kateri, Christina, Katsoula, Anastasia, Kokkotis, Georgios, Koureta, Evgenia, Lamouri, Charikleia, Markopoulos, Panagiotis, Palatianou, Maria, Pastras, Ploutarchos, Fasoulas, Konstantinos, Giouleme, Olga, Zampeli, Evanthia, Theodoropoulou, Aggeliki, and Theocharis, Georgios

Subjects
INFLAMMATORY bowel diseases, INTESTINAL diseases, CROHN'S disease, ANEMIA, ULCERATIVE colitis, ANEMIA treatment, RESEARCH, FERRANS & Powers Quality of Life Index, RESEARCH methodology, RETROSPECTIVE studies, MEDICAL cooperation, EVALUATION research, COMPARATIVE studies, QUALITY of life, DISEASE complications
Abstract

Background: Anemia is a common extraintestinal manifestation of Inflammatory Bowel Disease (IBD) affecting negatively the patients' quality of life. The aim of this study was to determine the frequency and real-life management of anemia in IBD patients in Greece.Methods: This study was conducted in 17 Greek IBD referral centers. Demographic, clinical, laboratory, IBD and anemia treatment data were collected and analyzed retrospectively.Results: A total of 1394 IBD patients [560 ulcerative colitis (UC), 834 Crohn's disease (CD)] were enrolled. Anemia at any time was reported in 687 (49.3%) patients of whom 413 (29.6%) had episodic and 274 (19.7%) had recurrent/persistent anemia. Anemia was diagnosed before IBD in 45 (6.5%), along with IBD in 269 (39.2%) and after IBD in 373 (54.3%) patients. In the multivariate analysis the presence of extraintestinal manifestations (p = 0.0008), IBD duration (p = 0.026), IBD related surgeries and hospitalizations (p = 0.026 and p = 0.004 accordingly) were risk factors of recurrent/persistent anemia. Serum ferritin was measured in 839 (60.2%) IBD patients. Among anemic patients, 535 (77.9%) received treatment. Iron supplementation was administered in 485 (90.6%) patients, oral in 142 (29.3%) and intravenous in 393 (81%).Conclusions: The frequency of anemia in IBD patients, followed at Greek referral centers, is approximately 50%. Development of recurrent/persistent anemia may be observed in 20% of cases and is independently associated with the presence of extraintestinal manifestations, IBD duration, IBD related surgeries and hospitalizations. Anemia treatment is administered in up to [Formula: see text] of anemia IBD patients with the majority of them receiving iron intravenously. [ABSTRACT FROM AUTHOR]

Published
2021
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20. Association of miR-146 rs2910164, miR-196a rs11614913, miR-221 rs113054794 and miR-224 rs188519172 polymorphisms with anti-TNF treatment response in a Greek population with Crohn’s disease

Author

Papaconstantinou, Ioannis Kapizioni, Christina Legaki, Evangelia Xourgia, Elena Karamanolis, George Gklavas, Antonios Gazouli, Maria

Abstract

AIM: To investigate the correlation between rs2910164, rs11 614913, rs113054794, and rs188519172 polymorphisms and response to anti-TNF treatment in patients with Crohn’s disease (CD). METHODS: One hundred seven patients with CD based on standard clinical, endoscopic, radiological, and pathological criteria were included in the study. They all received infliximab or adalimumab intravenously or subcutaneously at standard induction doses as per international guidelines. Clinical and biochemical response was assessed using the Harvey-Bradshaw index and CRP levels respectively. Endoscopic response was evaluated by ileocolonoscopy at week 12-20 of therapy. The changes in endoscopic appearance compared to baseline were classified into four categories, and patients were classified as responders and non-responders. Whole peripheral blood was extracted and genotyping was performed by PCR. RESULTS: One hundred and seven patients were included in the study. Seventy two (67.3%) patients were classified as complete responders, 22 (20.5%) as partial while 13 (12.1%) were primary non-responders. No correlation was detected between response to anti-TNF agents and patients’ characteristics such as gender, age and disease duration while clinical and biochemical indexes used were associated with endoscopic response. Concerning prevalence of rs2910164, rs11614913, and rs188519172 polymorphisms of miR-146, miR-196a and miR-224 respectively no statistically important difference was found between complete, partial, and non-responders to anti-TNF treatment. Actually CC genotype of rs2910164 was not detected in any patient. Regarding rs113054794 of miR-221, normal CC genotype was the only one detected in all studied patients, suggesting this polymorphism is highly rare in the studied population. CONCLUSION: No correlation is detected between studied polymorphisms and patients’ response to anti-TNF treatment. Polymorphism rs113054794 is not detected in our population.

Published
2017

22. Prevention of Malaria Resurgence in Greece through the Association of Mass Drug Administration (MDA) to Immigrants from Malaria-Endemic Regions and Standard Control Measures.

Author

Tseroni, Maria, Baka, Agoritsa, Kapizioni, Christina, Snounou, Georges, Tsiodras, Sotirios, Charvalakou, Maria, Georgitsou, Maria, Panoutsakou, Maria, Psinaki, Ioanna, Tsoromokou, Maria, Karakitsos, George, Pervanidou, Danai, Vakali, Annita, Mouchtouri, Varvara, Georgakopoulou, Theano, Mamuris, Zissis, Papadopoulos, Nikos, Koliopoulos, George, Badieritakis, Evangelos, and Diamantopoulos, Vasilis

Subjects
MALARIA prevention, MALARIA, PUBLIC health, HEALTH policy, DRUG administration laws, LAW
Abstract

Greece was declared malaria-free in 1974 after a long antimalarial fight. In 2011-2012, an outbreak of P. vivax malaria was reported in Evrotas, an agricultural area in Southern Greece, where a large number of immigrants from endemic countries live and work. A total of 46 locally acquired and 38 imported malaria cases were detected. Despite a significant decrease of the number of malaria cases in 2012, a mass drug administration (MDA) program was considered as an additional measure to prevent reestablishment of the disease in the area. During 2013 and 2014, a combination of 3-day chloroquine and 14-day primaquine treatment was administered under direct observation to immigrants living in the epicenter of the 2011 outbreak in Evrotas. Adverse events were managed and recorded on a daily basis. The control measures implemented since 2011 continued during the period of 2013-2014 as a part of a national integrated malaria control program that included active case detection (ACD), vector control measures and community education. The MDA program was started prior to the transmission periods (from May to December). One thousand ninety four (1094) immigrants successfully completed the treatment, corresponding to 87.3% coverage of the target population. A total of 688 adverse events were recorded in 397 (36.2%, 95% C.I.: 33.4-39.1) persons, the vast majority minor, predominantly dizziness and headache for chloroquine (284 events) and abdominal pain (85 events) for primaquine. A single case of primaquine-induced hemolysis was recorded in a person whose initial G6PD test proved incorrect. No malaria cases were recorded in Evrotas, Laconia, in 2013 and 2014, though three locally acquired malaria cases were recorded in other regions of Greece in 2013. Preventive antimalarial MDA to a high-risk population in a low transmission setting appears to have synergized with the usual antimalarial activities to achieve malaria elimination. This study suggests that judicious use of MDA can be a useful addition to the antimalarial armamentarium in areas threatened with the reintroduction of the disease. [ABSTRACT FROM AUTHOR]

Published
2015
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23. Correction to: The burden and management of anemia in Greek patients with inflammatory bowel disease: a retrospective, multicenter, observational study.

Author

Foteinogiannopoulou, Kalliopi, Karmiris, Konstantinos, Axiaris, Georgios, Velegraki, Magdalini, Gklavas, Antonios, Kapizioni, Christina, Karageorgos, Charalabos, Kateri, Christina, Katsoula, Anastasia, Kokkotis, Georgios, Koureta, Evgenia, Lamouri, Charikleia, Markopoulos, Panagiotis, Palatianou, Maria, Pastras, Ploutarchos, Fasoulas, Konstantinos, Giouleme, Olga, Zampeli, Evanthia, Theodoropoulou, Aggeliki, and Theocharis, Georgios

Subjects
INFLAMMATORY bowel diseases, SCIENTIFIC observation, ANEMIA
Abstract

Reference 1 Foteinogiannopoulou K, Karmiris K, Axiaris G. The burden and management of anemia in Greek patients with inflammatory bowel disease: a retrospective, multicenter, observational study. Correction to: BMC Gastroenterol 21, 269 (2021). https://doi.org/10.1186/s12876-021-01826-1 Following publication of the original article [[1]], it was reported that the affiliation of the corresponding author should be changed from "Dept. of Gastroenterology, University Hospital Heraklion, Heraklion, Crete, Greece" to "Gastroenterology Department, University Hospital of Heraklion, Medical School University of Crete, Greece". [Extracted from the article]

Published
2021
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24. Comparative performance and external validation of three different scores in predicting inadequate bowel preparation among Greek inpatients undergoing colonoscopy

Author

Paraskevas, Gkolfakis, Christina, Kapizioni, Georgios, Tziatzios, Antonio, Facciorusso, Leonardo, Frazzoni, Konstantinos, Thomopoulos, Spyros, Potamianos, Dimitrios, Christodoulou, Vasilios, Papadopoulos, Lorenzo, Fuccio, Cesare, Hassan, Konstantinos, Triantafyllou, Gkolfakis, Paraskeva, Kapizioni, Christina, Tziatzios, Georgio, Facciorusso, Antonio, Frazzoni, Leonardo, Thomopoulos, Konstantino, Potamianos, Spyro, Christodoulou, Dimitrio, Papadopoulos, Vasilio, Fuccio, Lorenzo, Hassan, Cesare, and Triantafyllou, Konstantinos

Subjects
bowel preparation, Colonoscopy, predictive score
Abstract

Background Predictive scores aim to predict bowel preparation adequacy among hospitalized patients undergoing colonoscopy. We evaluated the comparative efficacy of these scores in predicting inadequate bowel cleansing in a cohort of Greek inpatients. Methods We performed a post hoc analysis of data generated from a cohort of inpatients undergoing colonoscopy in 4 tertiary Greek centers to validate the 3 models currently available (models A, B and C). We used the Akaike information criterion to quantify the performance of each model, while Harrell's C-index, as the area under the receiver operating characteristics curve (AUC), verified the discriminative ability to predict inadequate bowel prep. Primary endpoint was the comparison of performance among models for predicting inadequate bowel cleansing. 70.7 +/- 15.4 years-were included in the analysis. Model B showed the highest performance (Harrell's C-index: AUC 77.2% vs. 72.6% and 57.5%, compared to models A and C, respectively). It also achieved higher performance for the subgroup of mobilized inpatients (Harrell's C-index: AUC 72.21% vs. 64.97% and 59.66%, compared to models A and C, respectively). Model B also performed better in predicting patients with incomplete colonoscopy due to inadequate bowel preparation (Harrell's C-index: AUC 74.23% vs. 69.07% and 52.76%, compared to models A and C, respectively).Conclusions Predictive model B outperforms its comparators in the prediction of inpatients with inadequate bowel preparation. This model is particularly advantageous when used to evaluate mobilized inpatients.

Published
2023

25. ECCO Guidelines on Therapeutics in Crohn's Disease: Medical Treatment.

Author

Gordon H, Minozzi S, Kopylov U, Verstockt B, Chaparro M, Buskens C, Warusavitarne J, Agrawal M, Allocca M, Atreya R, Battat R, Bettenworth D, Bislenghi G, Brown SR, Burisch J, Casanova MJ, Czuber-Dochan W, de Groof J, El-Hussuna A, Ellul P, Fidalgo C, Fiorino G, Gisbert JP, Sabino JG, Hanzel J, Holubar S, Iacucci M, Iqbal N, Kapizioni C, Karmiris K, Kobayashi T, Kotze PG, Luglio G, Maaser C, Moran G, Noor N, Papamichael K, Peros G, Reenaers C, Sica G, Sigall-Boneh R, Vavricka SR, Yanai H, Myrelid P, Adamina M, and Raine T

Subjects
Humans, Immunosuppressive Agents therapeutic use, Gastrointestinal Agents therapeutic use, Anti-Inflammatory Agents therapeutic use, Crohn Disease drug therapy, Crohn Disease therapy
Published
2024
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26. ECCO Guidelines on Therapeutics in Crohn's Disease: Surgical Treatment.

Author

Adamina M, Minozzi S, Warusavitarne J, Buskens CJ, Chaparro M, Verstockt B, Kopylov U, Yanai H, Vavricka SR, Sigall-Boneh R, Sica GS, Reenaers C, Peros G, Papamichael K, Noor N, Moran GW, Maaser C, Luglio G, Kotze PG, Kobayashi T, Karmiris K, Kapizioni C, Iqbal N, Iacucci M, Holubar S, Hanzel J, Sabino JG, Gisbert JP, Fiorino G, Fidalgo C, Ellu P, El-Hussuna A, de Groof J, Czuber-Dochan W, Casanova MJ, Burisch J, Brown SR, Bislenghi G, Bettenworth D, Battat R, Atreya R, Allocca M, Agrawal M, Raine T, Gordon H, and Myrelid P

Subjects
Humans, Preoperative Care methods, Preoperative Care standards, Immunosuppressive Agents therapeutic use, Crohn Disease surgery, Crohn Disease drug therapy
Abstract

This article is the second in a series of two publications on the European Crohn's and Colitis Organisation [ECCO] evidence-based consensus on the management of Crohn's disease. The first article covers medical management; the present article addresses surgical management, including preoperative aspects and drug management before surgery. It also provides technical advice for a variety of common clinical situations. Both articles together represent the evidence-based recommendations of the ECCO for Crohn's disease and an update of prior ECCO Guidelines., (© The Author(s) 2024. Published by Oxford University Press on behalf of European Crohn’s and Colitis Organisation. All rights reserved. For commercial re-use, please contact reprints@oup.com for reprints and translation rights for reprints. All other permissions can be obtained through our RightsLink service via the Permissions link on the article page on our site—for further information please contact journals.permissions@oup.com.)

Published
2024
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27. Gastric polyps: a retrospective cohort analysis of 23,668 endoscopies indicates changing epidemiological and phenotypic characteristics.

Author

Kapizioni C, Kourkoulis P, Kartsoli S, Koutoufaris G, Giannelis P, Mellos A, Milioni K, Michalopoulos G, Vrakas S, and Xourgias V

Abstract

Introduction: Growing adoption of endoscopic procedures in clinical practice has gradually increase the detection rate of gastric polypoid lesions., Aim: To identify the epidemiologic characteristics of gastric polyps as well as changes of these parameters during a 15-year period., Material and Methods: We reviewed all the upper endoscopies archived in our database reporting a polypoid lesion from 2003 to 2018. Demographic data, indication for endoscopy, morphological characteristics of polyps, histology, and presence of Helicobacter pylori were collected. We compared the abovementioned data between 2 periods: 2003-2010 and 2010-2018., Results: A total of 989 (4.2%) patients from 23,668 reviewed were identified to harbour a polypoid lesion. Mean patient age was 63.2 years, with 58.8% being female. Most polyps (65.2%) were less than 5 mm in diameter and located in the fundus. Hyperplastic polyps (HPs) were the predominant type (28.6%) while fundic gland polyps (FGPs) were found in 24.1% of patients. Adenomas were the least common type (2.7%). Other pathology was identified in 43.3%. Comparison between the 2 periods revealed a rise of FGPs against HPs with a concomitant shift of location from antrum to fundus and an increase in the number of polyps per patient., Conclusions: FGPs and HPs were the most common polyps found in our cohort, with a change of their pattern during the 15 years. It is imperative to acknowledge the distinct characteristics of gastric polyps so as to properly assess the malignant potential that some of them, or their surrounding gastric mucosa, harbour., Competing Interests: The authors declare no conflict of interest., (Copyright © 2024 Termedia.)

Published
2024
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28. Results of the Eighth Scientific Workshop of ECCO: Prevention and Treatment of Postoperative Recurrence in Patients With Crohn's Disease Undergoing an Ileocolonic Resection With Ileocolonic Anastomosis.

Author

Ferrante M, Pouillon L, Mañosa M, Savarino E, Allez M, Kapizioni C, Arebi N, Carvello M, Myrelid P, De Vries AC, Rivière P, Panis Y, and Domènech E

Subjects
Humans, Colon surgery, Quality of Life, Ileum surgery, Anastomosis, Surgical adverse effects, Anastomosis, Surgical methods, Recurrence, Retrospective Studies, Crohn Disease prevention & control, Crohn Disease surgery, Crohn Disease drug therapy
Abstract

Despite the introduction of biological therapies, an ileocolonic resection is often required in patients with Crohn's disease [CD]. Unfortunately, surgery is not curative, as many patients will develop postoperative recurrence [POR], eventually leading to further bowel damage and a decreased quality of life. The 8th Scientific Workshop of ECCO reviewed the available scientific data on both prevention and treatment of POR in patients with CD undergoing an ileocolonic resection, dealing with conventional and biological therapies, as well as non-medical interventions, including endoscopic and surgical approaches in case of POR. Based on the available data, an algorithm for the postoperative management in daily clinical practice was developed., (© The Author(s) 2023. Published by Oxford University Press on behalf of European Crohn’s and Colitis Organisation. All rights reserved. For permissions, please email: journals.permissions@oup.com.)

Published
2023
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29. ECCO Guidelines on Inflammatory Bowel Disease and Malignancies.

Author

Gordon H, Biancone L, Fiorino G, Katsanos KH, Kopylov U, Al Sulais E, Axelrad JE, Balendran K, Burisch J, de Ridder L, Derikx L, Ellul P, Greuter T, Iacucci M, Di Jiang C, Kapizioni C, Karmiris K, Kirchgesner J, Laharie D, Lobatón T, Molnár T, Noor NM, Rao R, Saibeni S, Scharl M, Vavricka SR, and Raine T

Subjects
Humans, Inflammatory Bowel Diseases complications, Inflammatory Bowel Diseases diagnosis, Inflammatory Bowel Diseases therapy, Crohn Disease, Neoplasms diagnosis, Neoplasms therapy
Published
2023
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