19 results on '"Kaoru Sogabe"'
Search Results
2. Consistency of supplied food and dentition status of the elderly in residential care homes
- Author
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Yoshiaki Nomura, Ayako Okada, Erika Kakuta, Ryoko Otsuka, Kaoru Sogabe, Kiyoshige Yamane, Taku Yamamoto, Yuko Shigeta, Shuji Shigemoto, Takumi Ogawa, and Nobuhiro Hanada
- Subjects
Supplied food consistency ,Care level ,Tooth contact ,Removable denture ,Dentistry ,RK1-715 - Abstract
Abstract Background The association between oral health and malnutrition has been investigated in detail. The nutrition of elderly subjects in residential care homes is determined by caregivers, dietitians or nutritionists and managed by changing the consistency of their supplied food. However, few reports have described the relationship between oral condition and supplied food consistency. The objective of this study was to determine dentition status and care levels that correlate with supplied food consistency among elderly residents of care facilities. In addition, we estimated the care level at which ordinary food consistency can be supplied by caregivers who cannot diagnose dental status. Method Several factors, including dentition, wearing removable dentures, meals categorized as ordinary or processed (sliced, mashed, or liquefied), and care levels according to the Japanese standardized care-needs certification system were investigated in 276 elderly residents (male, n = 56; female, n = 220; mean age, 87.68 ± 5.94 years) of 12 fee-based care facilities. Results The results of this study showed that care levels were significantly correlated with the consistency of the food supplied to the residents. When supplied food consistency was categorized as ordinary or processed, the number of remaining teeth and the number of tooth contact pairs, either natural or artificial, were statistically significant. From logistic regression analysis, it was determined that the numbers of tooth contact pairs were statistically significant among residents requiring high levels of care. Conclusion The number of tooth contact pairs, either natural or artificial, was one of the contributing factors for deciding supplied food consistency among elderly residents of care facilities. Elderly residents requiring less than care level 3 should have ordinary meals.
- Published
- 2019
- Full Text
- View/download PDF
3. Incidence of Postoperative Pneumonia and Oral Microbiome for Patients with Cancer Operation
- Author
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Yoshiaki Nomura, Yuko Inai, Yudai Shimpo, Ayako Okada, Yuko Yamamoto, Kaoru Sogabe, Naohisa Wada, and Nobuhiro Hanada
- Subjects
post operative pneumonia ,oral microbiome ,perioperative oral care management ,cancer operation ,Technology ,Engineering (General). Civil engineering (General) ,TA1-2040 ,Biology (General) ,QH301-705.5 ,Physics ,QC1-999 ,Chemistry ,QD1-999 - Abstract
Postoperative pneumonia is a serious problem for patients and medical staff. In Japan, many hospitals introduced perioperative oral care management for the efficient use of medical resources. However, a high percentage of postoperative pneumonia still developed. Therefore, there is a need to identify the specific respiratory pathogens to predict the incidence of pneumonia The purpose of this study was to find out the candidate of bacterial species for the postoperative pneumonia. This study applied case-control study design for the patients who had a cancer operation with or without postoperative pneumonia. A total of 10 patients undergoing a cancer operation under general anesthesia participated in this study. The day before a cancer operation, preoperative oral care management was applied. Using the next generation sequence, oral microbiome of these patients was analyzed at the time of their first visit, the day before and after a cancer operation. Porphyromonas gingivalis and Fusobacterium nucleatum group can be a high risk at first visit. Atopobium parvulum and Enterococcus faecalis before a cancer operation can be a high risk. Poor oral hygiene increased the risk of incidence of postoperative pneumonia. Increased periodontal pathogens can be a high risk of the incidence of postoperative pneumonia. In addition, increased intestinal bacteria after oral care management can also be a high risk for the incidence of postoperative pneumonia.
- Published
- 2022
- Full Text
- View/download PDF
4. Corrigendum to 'Prevalence of Dental Caries in 5- and 6-Year-Old Myanmar Children'
- Author
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Yoshiaki Nomura, Khin Maung, Eint Min Kay Khine, Khin Myo Sint, May Phyo Lin, Min Khaing Win Myint, Thu Aung, Kaoru Sogabe, Ryoko Otsuka, Ayako Okada, Erika Kakuta, Wit Yee Wint, Masahide Uraguchi, Ryo Hasegawa, and Nobuhiro Hanada
- Subjects
Dentistry ,RK1-715 - Published
- 2019
- Full Text
- View/download PDF
5. Prevalence of Dental Caries in 5- and 6-Year-Old Myanmar Children
- Author
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Yoshiaki Nomura, Khin Maung, Eint Min Kay Khine, Khin Myo Sint, May Phyo Lin, Min Khaing Win Myint, Thu Aung, Kaoru Sogabe, Ryoko Otsuka, Ayako Okada, Erika Kakuta, Wit Yee Wint, Masahide Uraguchi, Ryo Hasegawa, and Nobuhiro Hanada
- Subjects
Dentistry ,RK1-715 - Abstract
There are no national data available of the oral health in Myanmar. In this study, we examined dental caries status of 187 school children located in the suburban area of Naypyidaw, capital of Myanmar, at the age of five and six and analyzed by the individual level and tooth level. Maxillary D and B were sensitive for dental caries almost at the same level. They were less sensitive than maxillary A. Mandibular A and B were tolerant for dental caries. Prevalence of dental caries in Myanmar children was still high. By applying item response theory and multilevel modeling, tooth level analysis can be implemented to confirm the tendency for sensitivity or tolerance for dental caries by the tooth level.
- Published
- 2019
- Full Text
- View/download PDF
6. Structure and Validity of Questionnaire for Oral Frail Screening
- Author
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Yoshiaki Nomura, Yoshimasa Ishii, Yota Chiba, Shunsuke Suzuki, Akira Suzuki, Senichi Suzuki, Kenji Morita, Joji Tanabe, Koji Yamakawa, Yasuo Ishiwata, Meu Ishikawa, Kaoru Sogabe, Erika Kakuta, Ayako Okada, Ryoko Otsuka, and Nobuhiro Hanada
- Subjects
oral frailty ,screening ,validity ,Item Response Theory ,Medicine - Abstract
Oral frailty is defined as the mild decline in oral function and located at the early and reversible stage of frailty. Therefore, early detection and early treatment of oral frailty is very useful. Simple and easy questionnaires, such as an oral frailty checklist, have been widely used for the screening and enlightenment of oral frailty of the Japanese people. We evaluate the structure and validity of the oral frailty checklist. The questionnaire of oral frailty was distributed for the citizens more than 50 years old from December 2018 to January 2019. The structural validity of the questionnaire is analyzed by structural equation modeling (SEM). The characteristics of the items are analyzed by Item Response Theory (IRT). The data of 725 subjects (360 men, 359 women, 6 no answer, mean age 71.3 ± 9.05) are analyzed. The questionnaire consisted of three latent variables. Items of “Brushing teeth at least twice a day”, “Regular attendance of dental clinic”, and “Using denture”, had low discrimination ability. The questionnaire used in this study is a useful tool for the screening of oral frailty. However, its scoring system needs to be improved.
- Published
- 2021
- Full Text
- View/download PDF
7. Nutritional Status and Oral Frailty: A Community Based Study
- Author
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Yoshiaki Nomura, Yoshimasa Ishii, Shunsuke Suzuki, Kenji Morita, Akira Suzuki, Senichi Suzuki, Joji Tanabe, Yasuo Ishiwata, Koji Yamakawa, Yota Chiba, Meu Ishikawa, Kaoru Sogabe, Erika Kakuta, Ayako Okada, Ryoko Otsuka, and Nobuhiro Hanada
- Subjects
nutritional status ,population survey ,oral frailty ,health behavior ,Nutrition. Foods and food supply ,TX341-641 - Abstract
Compromised oral health can alter food choices. Poor masticatory function leads to imbalanced food intake and undesirable nutritional status. The associations among nutritional status, oral health behavior, and self-assessed oral functions status were investigated using a community-based survey. In total, 701 subjects more than 50 years old living Ebina city located southwest of the capital Tokyo were investigated. The number of remaining teeth was counted by dental hygienists. Oral health behavior and self-assessed oral functions were evaluated by oral frailty checklist. Nutritional status was evaluated by the brief-type self-administered diet history questionnaire using Dietary Reference Intakes for Japanese as reference. More than 80% of subjects’ intakes of vitamin B12, pantothenic acid, copper, and proteins were sufficient. In contrast, only 19% of subjects’ intake of vitamin A was sufficient and 35.5% for vitamin B1. More than 90% of subjects’ intakes of vitamin D and vitamin K were sufficient. Only 35.5% of subjects’ intakes of dietary fiber were sufficient. Overall, 88.9% of subjects had excess salt. The number of remaining teeth was not correlated with nutritional intakes. Oral health behavior significantly correlated with nutritional intakes. Oral functions are important for food choice; however, oral functions were not directly correlated with nutritional intakes. Comprehensive health instructions including nutrition and oral health education is necessary for health promotion.
- Published
- 2020
- Full Text
- View/download PDF
8. Structure and Validity of Questionnaire for Oral Frail Screening
- Author
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Kenji Morita, Joji Tanabe, Nobuhiro Hanada, Akira Suzuki, Senichi Suzuki, Meu Ishikawa, Yoshiaki Nomura, Shunsuke Suzuki, Yasuo Ishiwata, Erika Kakuta, Kaoru Sogabe, Ryoko Otsuka, Yota Chiba, Koji Yamakawa, Yoshimasa Ishii, and Ayako Okada
- Subjects
Gerontology ,validity ,Scoring system ,Leadership and Management ,Item Response Theory ,lcsh:Medicine ,Early detection ,Health Informatics ,Structural equation modeling ,Article ,03 medical and health sciences ,0302 clinical medicine ,Health Information Management ,Oral function ,Item response theory ,Medicine ,030212 general & internal medicine ,oral frailty ,business.industry ,Health Policy ,screening ,lcsh:R ,Attendance ,030206 dentistry ,Checklist ,stomatognathic diseases ,Dental clinic ,business - Abstract
Oral frailty is defined as the mild decline in oral function and located at the early and reversible stage of frailty. Therefore, early detection and early treatment of oral frailty is very useful. Simple and easy questionnaires, such as an oral frailty checklist, have been widely used for the screening and enlightenment of oral frailty of the Japanese people. We evaluate the structure and validity of the oral frailty checklist. The questionnaire of oral frailty was distributed for the citizens more than 50 years old from December 2018 to January 2019. The structural validity of the questionnaire is analyzed by structural equation modeling (SEM). The characteristics of the items are analyzed by Item Response Theory (IRT). The data of 725 subjects (360 men, 359 women, 6 no answer, mean age 71.3 ±, 9.05) are analyzed. The questionnaire consisted of three latent variables. Items of &ldquo, Brushing teeth at least twice a day&rdquo, &ldquo, Regular attendance of dental clinic&rdquo, and &ldquo, Using denture&rdquo, had low discrimination ability. The questionnaire used in this study is a useful tool for the screening of oral frailty. However, its scoring system needs to be improved.
- Published
- 2021
- Full Text
- View/download PDF
9. Does Last Year’s Cost Predict the Present Cost? An Application of Machine Leaning for the Japanese Area-Basis Public Health Insurance Database
- Author
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Nobuhiro Hanada, Koji Yamakawa, Erika Kakuta, Ryoko Otsuka, Yoshiaki Nomura, Kaoru Sogabe, Shunsuke Suzuki, Kenji Morita, Yota Chiba, Yoshimasa Ishii, Meu Ishikawa, Ayako Okada, Senichi Suzuki, Yasuo Ishiwata, Akira Suzuki, and Joji Tanabe
- Subjects
Databases, Factual ,Policy making ,neural network ,Health, Toxicology and Mutagenesis ,Observation period ,lcsh:Medicine ,Oral health ,healthcare cost ,computer.software_genre ,Article ,03 medical and health sciences ,0302 clinical medicine ,Cost of Illness ,Japan ,Medication cost ,Per capita ,Humans ,dental healthcare cost ,030212 general & internal medicine ,health care economics and organizations ,Government ,Insurance, Health ,Database ,Public health insurance ,lcsh:R ,Public Health, Environmental and Occupational Health ,030206 dentistry ,Health Care Costs ,medical healthcare cost ,zero-inflated model ,Healthcare cost ,Business ,computer - Abstract
The increasing healthcare cost imposes a large economic burden for the Japanese government. Predicting the healthcare cost may be a useful tool for policy making. A database of the area-basis public health insurance of one city was analyzed to predict the medical healthcare cost by the dental healthcare cost with a machine learning strategy. The 30,340 subjects who had continued registration of the area-basis public health insurance of Ebina city during April 2017 to September 2018 were analyzed. The sum of the healthcare cost was JPY 13,548,831,930. The per capita healthcare cost was JPY 446,567. The proportion of medical healthcare cost, medication cost, and dental healthcare cost was 78%, 15%, and 7%, respectively. By the results of the neural network model, the medical healthcare cost proportionally depended on the medical healthcare cost of the previous year. The dental healthcare cost of the previous year had a reducing effect on the medical healthcare cost. However, the effect was very small. Oral health may be a risk for chronic diseases. However, when evaluated by the healthcare cost, its effect was very small during the observation period.
- Published
- 2021
10. Effects of the Dental Caries Preventive Procedure on the White Spot Lesions during Orthodontic Treatment—An Open Label Randomized Controlled Trial
- Author
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Yudai Shimpo, Yoshiaki Nomura, Toshiko Sekiya, Chihiro Arai, Ayako Okada, Kaoru Sogabe, Nobuhiro Hanada, and Hiroshi Tomonari
- Subjects
stomatognathic diseases ,oral microbiome ,tooth surface disinfection ,Medicine ,General Medicine ,fixed orthodontic treatment ,quantitative light-induced fluorescence ,mixed effect model - Abstract
(1) Background: The aim of this study was to assess the preventive effect of tooth surface disinfection treatment, in addition to fluoride application, during fixed orthodontic treatment. (2) Methods: An open label randomized control trial for the evaluation of the dental caries preventive procedure was performed for the patients with high caries risk who had been visited at Department of Orthodontics, Tsurumi University Dental Hospital for orthodontics treatment. The follow-up period was six months. White spot lesions (WSLs) were evaluated by quantitative light-induced fluorescence (QLF). Cariogenic bacteria were monitored and evaluated by bacterial culture. In addition, the oral microbiome was evaluated by a next-generation sequence (NGS). (3) Results: By the mixed effect modeling, tooth surface disinfection treatment significantly reduced cariogenic bacteria and all parameters obtained by QLF. (4) Conclusions: Tooth surface disinfection treatment, in addition to PMTC and fluoride application, were effective for dental caries prevention and keeping a healthy microbiome during orthodontic treatment.
- Published
- 2022
11. Nutritional Status and Oral Frailty: A Community Based Study
- Author
-
Senichi Suzuki, Nobuhiro Hanada, Shunsuke Suzuki, Yota Chiba, Ryoko Otsuka, Akira Suzuki, Yoshiaki Nomura, Joji Tanabe, Yasuo Ishiwata, Kenji Morita, Yoshimasa Ishii, Koji Yamakawa, Ayako Okada, Meu Ishikawa, Erika Kakuta, and Kaoru Sogabe
- Subjects
Vitamin ,Male ,Nutritional Status ,lcsh:TX341-641 ,Oral Health ,Article ,03 medical and health sciences ,chemistry.chemical_compound ,Eating ,0302 clinical medicine ,health behavior ,Japan ,Environmental health ,Surveys and Questionnaires ,Food choice ,Pantothenic acid ,Vitamin D and neurology ,Medicine ,Humans ,030212 general & internal medicine ,Vitamin B12 ,Aged ,Aged, 80 and over ,oral frailty ,Nutrition and Dietetics ,Frailty ,business.industry ,030206 dentistry ,Feeding Behavior ,Middle Aged ,Nutrition Surveys ,Checklist ,population survey ,stomatognathic diseases ,Health promotion ,chemistry ,Dietary Reference Intake ,Female ,Public Health ,business ,lcsh:Nutrition. Foods and food supply ,Food Science - Abstract
Compromised oral health can alter food choices. Poor masticatory function leads to imbalanced food intake and undesirable nutritional status. The associations among nutritional status, oral health behavior, and self-assessed oral functions status were investigated using a community-based survey. In total, 701 subjects more than 50 years old living Ebina city located southwest of the capital Tokyo were investigated. The number of remaining teeth was counted by dental hygienists. Oral health behavior and self-assessed oral functions were evaluated by oral frailty checklist. Nutritional status was evaluated by the brief-type self-administered diet history questionnaire using Dietary Reference Intakes for Japanese as reference. More than 80% of subjects&rsquo, intakes of vitamin B12, pantothenic acid, copper, and proteins were sufficient. In contrast, only 19% of subjects&rsquo, intake of vitamin A was sufficient and 35.5% for vitamin B1. More than 90% of subjects&rsquo, intakes of vitamin D and vitamin K were sufficient. Only 35.5% of subjects&rsquo, intakes of dietary fiber were sufficient. Overall, 88.9% of subjects had excess salt. The number of remaining teeth was not correlated with nutritional intakes. Oral health behavior significantly correlated with nutritional intakes. Oral functions are important for food choice, however, oral functions were not directly correlated with nutritional intakes. Comprehensive health instructions including nutrition and oral health education is necessary for health promotion.
- Published
- 2020
12. Characterization of specimens obtained by different sampling methods for evaluation of periodontal bacteria
- Author
-
Hiroaki Takeuchi, Yoshiaki Nomura, Ayako Okada, Masaaki Okamoto, Nobuhiro Hanada, and Kaoru Sogabe
- Subjects
Adult ,Male ,Periodontium ,0301 basic medicine ,Saliva ,Colony Count, Microbial ,Dental Plaque ,Gingiva ,Dentistry ,Periodontal bacteria ,03 medical and health sciences ,0302 clinical medicine ,stomatognathic system ,Periodontal disease ,Humans ,Periodontal Pocket ,Medicine ,Tannerella forsythia ,Periodontitis ,General Dentistry ,Porphyromonas gingivalis ,Bacteriological Techniques ,biology ,business.industry ,Treponema denticola ,030206 dentistry ,Middle Aged ,biology.organism_classification ,stomatognathic diseases ,030104 developmental biology ,Clinical diagnosis ,Female ,business ,Bacteria - Abstract
Quantitative analysis of periodontal bacteria is considered useful for clinical diagnosis, evaluation and assessment of the risk of periodontal disease. The purpose of this study was to compare the effectiveness of sampling of saliva, supragingival and subgingival plaque for evaluation of periodontal bacteria. From each of 12 subjects, i) subgingival plaque was collected from the deepest pocket using a sterile paper point, ii) stimulated whole saliva was collected after chewing gum, and iii) supragingival plaque was collected using a tooth brush. These samples were sent to the medical examination laboratory for quantitative analysis of the counts of three periodontal bacterial species: Porphyromonas gingivalis, Treponema denticola, and Tannerella forsythia. The proportions of these bacteria in subgingival plaque were higher than those in saliva or supragingival plaque, but lower in subgingival plaque than in saliva or supragingival plaque. In several cases, periodontal bacteria were below the levels of detection in subgingival plaque. We concluded that samples taken from subgingival plaque may be more useful for evaluating the proportion of periodontal bacteria in deep pockets than is the case for other samples. Therefore, for evaluation of periodontal bacteria, clinicians should consider the characteristics of the specimens obtained using different sampling methods.
- Published
- 2017
13. Corrigendum to 'Prevalence of Dental Caries in 5- and 6-Year-Old Myanmar Children'
- Author
-
Erika Kakuta, Khin Maung, Kaoru Sogabe, Yoshiaki Nomura, Nobuhiro Hanada, Khin Myo Sint, Min Khaing Win Myint, Masahide Uraguchi, Wit Yee Wint, Ryoko Otsuka, May Phyo Lin, Ayako Okada, Eint Min Kay Khine, Ryo Hasegawa, and Thu Aung
- Subjects
lcsh:RK1-715 ,lcsh:Dentistry ,Corrigendum ,General Dentistry - Abstract
There are no national data available of the oral health in Myanmar. In this study, we examined dental caries status of 187 school children located in the suburban area of Naypyidaw, capital of Myanmar, at the age of five and six and analyzed by the individual level and tooth level. Maxillary D and B were sensitive for dental caries almost at the same level. They were less sensitive than maxillary A. Mandibular A and B were tolerant for dental caries. Prevalence of dental caries in Myanmar children was still high. By applying item response theory and multilevel modeling, tooth level analysis can be implemented to confirm the tendency for sensitivity or tolerance for dental caries by the tooth level.
- Published
- 2019
14. Consistency of supplied food and dentition status of the elderly in residential care homes
- Author
-
Nobuhiro Hanada, Taku Yamamoto, Shuji Shigemoto, Erika Kakuta, Yuko Shigeta, Yoshiaki Nomura, Kaoru Sogabe, Takumi Ogawa, Ryoko Otsuka, Ayako Okada, and Kiyoshige Yamane
- Subjects
Male ,medicine.medical_specialty ,Health Services for the Aged ,medicine.medical_treatment ,Nutritional Status ,Oral Health ,Logistic regression ,Food Supply ,03 medical and health sciences ,0302 clinical medicine ,Environmental health ,Health care ,medicine ,Removable denture ,Dentition ,Homes for the Aged ,Humans ,030212 general & internal medicine ,General Dentistry ,Socioeconomic status ,Aged ,Aged, 80 and over ,Tooth contact ,business.industry ,Care level ,Public health ,030206 dentistry ,medicine.disease ,Nursing Homes ,lcsh:RK1-715 ,Malnutrition ,Long-term care ,lcsh:Dentistry ,Female ,Dentures ,Supplied food consistency ,business ,Mouth Diseases ,Delivery of Health Care ,Research Article - Abstract
Background The association between oral health and malnutrition has been investigated in detail. The nutrition of elderly subjects in residential care homes is determined by caregivers, dietitians or nutritionists and managed by changing the consistency of their supplied food. However, few reports have described the relationship between oral condition and supplied food consistency. The objective of this study was to determine dentition status and care levels that correlate with supplied food consistency among elderly residents of care facilities. In addition, we estimated the care level at which ordinary food consistency can be supplied by caregivers who cannot diagnose dental status. Method Several factors, including dentition, wearing removable dentures, meals categorized as ordinary or processed (sliced, mashed, or liquefied), and care levels according to the Japanese standardized care-needs certification system were investigated in 276 elderly residents (male, n = 56; female, n = 220; mean age, 87.68 ± 5.94 years) of 12 fee-based care facilities. Results The results of this study showed that care levels were significantly correlated with the consistency of the food supplied to the residents. When supplied food consistency was categorized as ordinary or processed, the number of remaining teeth and the number of tooth contact pairs, either natural or artificial, were statistically significant. From logistic regression analysis, it was determined that the numbers of tooth contact pairs were statistically significant among residents requiring high levels of care. Conclusion The number of tooth contact pairs, either natural or artificial, was one of the contributing factors for deciding supplied food consistency among elderly residents of care facilities. Elderly residents requiring less than care level 3 should have ordinary meals. Electronic supplementary material The online version of this article (10.1186/s12903-019-0770-0) contains supplementary material, which is available to authorized users.
- Published
- 2019
15. Opportunistic Bacteria in Tonsil and Dental Plaque are Indicator for Oral Care
- Author
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Yoshiaki Nomura, Masaaki Okamoto, Nobuhiro Hanada, Chiyoko Hakuta, Erika Kakuta, Susumu Imai, Ayako Okada, Kaoru Sogabe, and Keiko Endo
- Subjects
biology ,business.industry ,fungi ,food and beverages ,Dentistry ,biology.organism_classification ,Dental plaque ,medicine.disease ,medicine.anatomical_structure ,Oral microbiology ,Tonsil ,parasitic diseases ,medicine ,business ,Bacteria - Abstract
Background of the study: Detection of the opportunistic microorganisms can be the indicator for
- Published
- 2016
16. Comparison of salivary hemoglobin measurements for periodontitis screening
- Author
-
Keita Shimizu, Keizo Koresawa, Nobuhiro Hanada, Hirokazu Yoshino, Yasushi Tobi, Yoichi Fukuzawa, Hisanori Utsunomiya, Hideo Hayashi, Kazuyuki Suzuki, Mami Kotoh, Arika Sato Gillbreath, Kaoru Sogabe, Hirofumi Oku, Naoyuki Nishitsuji, Yoshihide Yabuki, Masataka Yajima, Takakazu Nakasone, Kenji Koba, Yoshinobu Naono, Kimiyuki Uetani, Yoshiaki Nomura, Fumihiko Hino, Satoshi Akutsu, and Ayako Okada
- Subjects
Adult ,Male ,Saliva ,medicine.medical_specialty ,Correlation coefficient ,Dentistry ,Gastroenterology ,03 medical and health sciences ,Hemoglobins ,0302 clinical medicine ,Internal medicine ,medicine ,Humans ,Circadian rhythm ,Periodontitis ,General Dentistry ,Morning ,Aged ,business.industry ,Fecal occult blood ,030206 dentistry ,Middle Aged ,medicine.disease ,Friedman test ,030220 oncology & carcinogenesis ,Female ,Hemoglobin ,business - Abstract
Salivary hemoglobin (Hb) for screening of periodontitis is approved under the pharmaceutical affairs law of Japan. Two reagents are commercially available for the modified fecal occult blood test: Saliva Hemo Plus and OC-AUTO S Latex Reagent. We simultaneously measured split specimens from 561 samples by using these two methods and compared the differences and agreement between both methods. Moreover, saliva samples were collected from 10 subjects at five time points during the day for analysis of circadian variations and fluctuation. The Pearson's correlation coefficient for these two reagents was 0.794. The Bland-Altman plot of differences in salivary Hb levels measured by the two reagents indicated that the difference included fixed errors (0.55 μg/mL). On analysis of circadian variations, no statistically significant differences were observed using the Friedman test. However, fixed errors were observed between wake-up time and before dinner and before lunch and before dinner, and no random errors were observed by Bland-Altman analysis. In conclusion, the salivary Hb levels measured using OC-AUTO S Latex Reagent were lower than those measured using Saliva Hemo Plus, along with a tendency for higher levels in the morning. Thus, when performing salivary tests these observations must be considered.
- Published
- 2017
17. Chair-side detection of Prevotella Intermedia in mature dental plaque by its fluorescence
- Author
-
Masaaki Okamoto, Ayako Okada, Hiroaki Takeuchi, Yoshiaki Nomura, Kaoru Sogabe, and Nobuhiro Hanada
- Subjects
0301 basic medicine ,Adult ,Male ,Point-of-Care Systems ,030106 microbiology ,Biophysics ,Dental Plaque ,Protoporphyrins ,Dermatology ,Dental plaque ,Prevotella intermedia ,Periodontal pathogen ,Microbiology ,03 medical and health sciences ,chemistry.chemical_compound ,0302 clinical medicine ,stomatognathic system ,medicine ,Bacteroidaceae Infections ,Tannerella forsythia ,Humans ,Pharmacology (medical) ,Porphyromonas gingivalis ,Photosensitizing Agents ,biology ,Protoporphyrin IX ,030206 dentistry ,biology.organism_classification ,medicine.disease ,Fluorescence ,Bacterial Load ,stomatognathic diseases ,Spectrometry, Fluorescence ,Oncology ,Relative fluorescence units ,chemistry ,Female - Abstract
Background Prevotella intermedia/nigrescens is one of the well-known pathogens causing periodontal diseases, and the red florescence excited by the visible blue light caused by the protoporphyrin IX in the bacterial cells could be useful for the chair-side detection. The aim of this study was to evaluated levels of periodontal pathogen, especially P. intermedia in clinical samples of red fluorescent dental plaque. Methods Thirty two supra gingival plaque samples from six individuals were measured its fluorescence at 640 nm wavelength excited by 409 nm. Periodontopathic bacteria were counted by the Invader PLUS PCR assay. Co-relations the fluorescence intensity and bacterial counts were analyzed by Person’s correlation coefficient and simple and multiple regression analysis. Positive and negative predictive values of the fluorescence intensities for with or without P. intermedia in supragingival plaque was calculated. Results When relative fluorescence unit (RFU) were logarithmic transformed, statistically significant linear relations between RFU and bacterial counts were obtained for P. intermedia , Porphyromonas gingivalis and Tannerella forsythia . By the multiple regression analysis, only P. intermedia had statistically significant co-relation with fluorescence intensities. All of the fluorescent dental plaque contained P. intermedia m. In contrast, 28% of non-fluorescent plaques contained P. intermedia . Conclusion To check the fluorescence dental plaque in the oral cavity could be the simple chair-side screening of the mature dental plaque before examining the periodontal pathogens especially P. intermedia by the PCR method.
- Published
- 2016
18. Characterization of specimens obtained by different sampling methods for evaluation of periodontal bacteria.
- Author
-
Ayako Okada, Kaoru Sogabe, Hiroaki Takeuchi, Masaaki Okamoto, Yoshiaki Nomura, Nobuhiro Hanada, Okada, Ayako, Sogabe, Kaoru, Takeuchi, Hiroaki, Okamoto, Masaaki, Nomura, Yoshiaki, and Hanada, Nobuhiro
- Subjects
PERIODONTAL disease diagnosis ,ORAL microbiology ,PORPHYROMONAS gingivalis ,RISK factors of periodontal disease ,DIAGNOSTIC specimens ,SALIVA microbiology ,BACTERIA ,BACTERIAL growth ,BACTERIOLOGY technique ,DENTAL plaque ,GINGIVA ,MICROBIOLOGICAL techniques ,PERIODONTAL pockets ,PERIODONTITIS ,PERIODONTIUM ,GRAM-negative anaerobic bacteria - Abstract
Quantitative analysis of periodontal bacteria is considered useful for clinical diagnosis, evaluation and assessment of the risk of periodontal disease. The purpose of this study was to compare the effectiveness of sampling of saliva, supragingival and subgingival plaque for evaluation of periodontal bacteria. From each of 12 subjects, i) subgingival plaque was collected from the deepest pocket using a sterile paper point, ii) stimulated whole saliva was collected after chewing gum, and iii) supragingival plaque was collected using a tooth brush. These samples were sent to the medical examination laboratory for quantitative analysis of the counts of three periodontal bacterial species: Porphyromonas gingivalis, Treponema denticola, and Tannerella forsythia. The proportions of these bacteria in subgingival plaque were higher than those in saliva or supragingival plaque, but lower in subgingival plaque than in saliva or supragingival plaque. In several cases, periodontal bacteria were below the levels of detection in subgingival plaque. We concluded that samples taken from subgingival plaque may be more useful for evaluating the proportion of periodontal bacteria in deep pockets than is the case for other samples. Therefore, for evaluation of periodontal bacteria, clinicians should consider the characteristics of the specimens obtained using different sampling methods. [ABSTRACT FROM AUTHOR]
- Published
- 2017
- Full Text
- View/download PDF
19. Comparison of salivary hemoglobin measurements for periodontitis screening.
- Author
-
Ayako Okada, Yoshiaki Nomura, Kaoru Sogabe, Hirofumi Oku, Gillbreath, Arika Sato, Fumihiko Hino, Hideo Hayashi, Hirokazu Yoshino, Hisanori Utsunomiya, Kazuyuki Suzuki, Keizo Koresawa, Kenji Koba, Kimiyuki Uetani, Mami Kotoh, Naoyuki Nishitsuji, Satoshi Akutsu, Takakazu Nakasone, Yasushi Tobi, Yoichi Fukuzawa, and Yoshihide Yabuki
- Subjects
HEMOGLOBINS ,PERIODONTITIS ,BLOOD testing ,SALIVA ,CHEMICAL reagents ,COMPARATIVE studies ,RESEARCH methodology ,MEDICAL cooperation ,RESEARCH ,EVALUATION research ,DIAGNOSIS - Abstract
Salivary hemoglobin (Hb) for screening of periodontitis is approved under the pharmaceutical affairs law of Japan. Two reagents are commercially available for the modified fecal occult blood test: Saliva Hemo Plus and OC-AUTO S Latex Reagent. We simultaneously measured split specimens from 561 samples by using these two methods and compared the differences and agreement between both methods. Moreover, saliva samples were collected from 10 subjects at five time points during the day for analysis of circadian variations and fluctuation. The Pearson's correlation coefficient for these two reagents was 0.794. The Bland-Altman plot of differences in salivary Hb levels measured by the two reagents indicated that the difference included fixed errors (0.55 μg/mL). On analysis of circadian variations, no statistically significant differences were observed using the Friedman test. However, fixed errors were observed between wake-up time and before dinner and before lunch and before dinner, and no random errors were observed by Bland-Altman analysis. In conclusion, the salivary Hb levels measured using OC-AUTO S Latex Reagent were lower than those measured using Saliva Hemo Plus, along with a tendency for higher levels in the morning. Thus, when performing salivary tests these observations must be considered. [ABSTRACT FROM AUTHOR]
- Published
- 2017
- Full Text
- View/download PDF
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