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We report a novel application of optical coherence tomography (OCT), to monitor post-laser irradiation collagen injury in skin model. An artificial skin model (RAFT) which closely approximates human skin, was irradiated with a Perovskite laser (λ = 1341 nm). We investigated dynamic changes in a RAFT after laser irradiation through OCT and compared the results to those of histology. OCT images clearly delineated areas of post-irradiation collagen injury and allowed non-invasive monitoring of the wound healing process. Histology was correlated well with OCT images. OCT has advantages because it is non-invasive and allows serial monitoring at the same site over time. Our study showed that OCT may be a useful tool for determination of optimal parameters for non-ablative laser skin rejuvenation (NALSR) using different devices.

We demonstrate a novel application of optical coherence tomography (OCT) to monitor post-laser irradiation collagen injury in model skin. An artificial skin model (RAFT), which closely approximates human skin, was irradiated with a Perovskite laser (λ = 1341 nm), which is under investigation for potential use as a nonablative laser skin rejuvenation device (NALSR). OCT was used to determine the extent of laser injury immediately post irradiation and, subsequently, to monitor tissue recovery over a seven-day period. OCT images clearly delineated areas of post-irradiation collagen injury and allowed noninvasive monitoring of the wound healing process. Histology was used for comparison and correlated well with OCT images. OCT offers advantages over standard histology as it is noninvasive and allows serial monitoring at the same site over time. Our results indicate that OCT has potential as a method for characterization of collagen injury post-laser irradiation and may be a useful tool for determination of optimal parameters for NALSR using different devices under investigation for this indication.